BDP1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1artery smooth muscle contraction (GO:0014824)8.33841131
2tonic smooth muscle contraction (GO:0014820)7.35777460
3vascular smooth muscle contraction (GO:0014829)6.71723282
4L-serine transport (GO:0015825)5.53185775
5sequestering of actin monomers (GO:0042989)5.45814235
6intestinal epithelial cell development (GO:0060576)4.71095361
7platelet dense granule organization (GO:0060155)4.55550965
8serine transport (GO:0032329)4.41003313
9positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.29734115
10head development (GO:0060322)4.26672456
11histamine secretion (GO:0001821)3.97965273
12regulation of cilium movement (GO:0003352)3.81580654
13organelle disassembly (GO:1903008)3.74040969
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.72387787
15ribonucleoprotein complex disassembly (GO:0032988)3.68819732
16negative regulation of axon extension involved in axon guidance (GO:0048843)3.68802148
17purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.68246378
18positive regulation of actin filament depolymerization (GO:0030836)3.66757768
19presynaptic membrane assembly (GO:0097105)3.62497202
20sleep (GO:0030431)3.59176003
21spinal cord development (GO:0021510)3.56387323
22single strand break repair (GO:0000012)3.53947335
23behavioral response to nicotine (GO:0035095)3.53712428
24vasoconstriction (GO:0042310)3.49099887
25cAMP catabolic process (GO:0006198)3.47931025
26behavioral response to cocaine (GO:0048148)3.46482490
27positive regulation of odontogenesis (GO:0042482)3.42237128
28serotonin receptor signaling pathway (GO:0007210)3.38692110
29striatum development (GO:0021756)3.31581955
30cyclic nucleotide catabolic process (GO:0009214)3.27230538
31protein neddylation (GO:0045116)3.27221541
32negative regulation of execution phase of apoptosis (GO:1900118)3.26935620
33histamine transport (GO:0051608)3.20810594
34base-excision repair, AP site formation (GO:0006285)3.19874091
35female gonad development (GO:0008585)3.19211110
36mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.17340397
37positive regulation of catenin import into nucleus (GO:0035413)3.15972117
38negative regulation of axon guidance (GO:1902668)3.13294940
39presynaptic membrane organization (GO:0097090)3.09187937
40axoneme assembly (GO:0035082)3.07843057
41mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.07599552
42nodal signaling pathway (GO:0038092)3.06287492
43neural crest cell development (GO:0014032)3.03568198
44Rap protein signal transduction (GO:0032486)2.99731354
45negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.95609950
46smooth muscle contraction (GO:0006939)2.95306315
47organ formation (GO:0048645)2.94011224
48regulation of dopamine secretion (GO:0014059)2.91321141
49hippo signaling (GO:0035329)2.86874167
50positive regulation of mitochondrial fission (GO:0090141)2.83102226
51protein prenylation (GO:0018342)2.80960474
52prenylation (GO:0097354)2.80960474
53positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.79454047
54detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.77676546
55vasodilation (GO:0042311)2.75881046
56purine deoxyribonucleotide metabolic process (GO:0009151)2.75714343
57DNA damage response, detection of DNA damage (GO:0042769)2.75316837
58positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)2.74820690
59enteric nervous system development (GO:0048484)2.71531544
60aldehyde catabolic process (GO:0046185)2.70835394
61regulation of activin receptor signaling pathway (GO:0032925)2.69216547
62nonmotile primary cilium assembly (GO:0035058)2.66194355
63membrane hyperpolarization (GO:0060081)2.65638464
64regulation of execution phase of apoptosis (GO:1900117)2.65186650
65activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.65150372
66signal peptide processing (GO:0006465)2.64684427
67phosphatidylserine metabolic process (GO:0006658)2.64014517
68glomerular filtration (GO:0003094)2.63586724
69neuron recognition (GO:0008038)2.63423780
70regulation of blood vessel size (GO:0050880)2.60330178
71positive regulation of protein depolymerization (GO:1901881)2.60194370
72regulation of tube size (GO:0035150)2.58774646
73ATP synthesis coupled proton transport (GO:0015986)2.58271614
74energy coupled proton transport, down electrochemical gradient (GO:0015985)2.58271614
75urinary tract smooth muscle contraction (GO:0014848)2.56566715
76retinal ganglion cell axon guidance (GO:0031290)2.54251329
77protein complex biogenesis (GO:0070271)2.54071313
78anterograde synaptic vesicle transport (GO:0048490)2.53833046
79mitochondrial respiratory chain complex assembly (GO:0033108)2.53644769
80axonal fasciculation (GO:0007413)2.52823671
81glucosamine-containing compound catabolic process (GO:1901072)2.52542513
82mitochondrial fission (GO:0000266)2.51676107
83cilium morphogenesis (GO:0060271)2.51162221
84postsynaptic membrane organization (GO:0001941)2.50890774
85negative regulation of B cell proliferation (GO:0030889)2.49561858
86purine deoxyribonucleotide catabolic process (GO:0009155)2.49549960
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.48005910
88mitochondrial respiratory chain complex I assembly (GO:0032981)2.48005910
89NADH dehydrogenase complex assembly (GO:0010257)2.48005910
90negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.47939264
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.47674223
92cAMP metabolic process (GO:0046058)2.46782795
93neural tube formation (GO:0001841)2.46555995
94xenobiotic catabolic process (GO:0042178)2.44864646
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.43002443
96mesenchymal cell development (GO:0014031)2.42494385
97epithelial cilium movement (GO:0003351)2.40649114
98negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.40427700
99indolalkylamine catabolic process (GO:0046218)2.39319508
100tryptophan catabolic process (GO:0006569)2.39319508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.54487757
2VDR_22108803_ChIP-Seq_LS180_Human3.38625349
3TAF15_26573619_Chip-Seq_HEK293_Human3.35915699
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82956604
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.82377464
6GBX2_23144817_ChIP-Seq_PC3_Human2.77830570
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.72669790
8P300_19829295_ChIP-Seq_ESCs_Human2.59190286
9FUS_26573619_Chip-Seq_HEK293_Human2.48897504
10IGF1R_20145208_ChIP-Seq_DFB_Human2.47335012
11ZNF274_21170338_ChIP-Seq_K562_Hela2.45408760
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37074216
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34802255
14EWS_26573619_Chip-Seq_HEK293_Human2.30846251
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18417874
16SMAD2/3_21741376_ChIP-Seq_EPCs_Human2.03763324
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.99058882
18POU5F1_16153702_ChIP-ChIP_HESCs_Human1.91380817
19BCAT_22108803_ChIP-Seq_LS180_Human1.91165815
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90500464
21SMAD3_21741376_ChIP-Seq_EPCs_Human1.88831578
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87880212
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85717003
24RNF2_27304074_Chip-Seq_NSC_Mouse1.83656865
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.83433889
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.77811709
27TOP2B_26459242_ChIP-Seq_MCF-7_Human1.76096613
28AR_25329375_ChIP-Seq_VCAP_Human1.72527419
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.69013777
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.68052351
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63892769
32ER_23166858_ChIP-Seq_MCF-7_Human1.62350877
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53765386
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53705032
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52605154
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51400372
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51277923
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49209639
39EZH2_22144423_ChIP-Seq_EOC_Human1.48234535
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45335047
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45335047
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44667813
43FLI1_21867929_ChIP-Seq_TH2_Mouse1.43412660
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.42389375
45KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.40348544
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38982352
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.38594569
48MYC_18940864_ChIP-ChIP_HL60_Human1.37546591
49SMAD4_21799915_ChIP-Seq_A2780_Human1.36844163
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34034099
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.33602077
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33250071
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30960221
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30818991
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30317845
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29933459
57ELK1_19687146_ChIP-ChIP_HELA_Human1.29746956
58SMAD4_21741376_ChIP-Seq_EPCs_Human1.27577256
59TBX3_20139965_ChIP-Seq_ESCs_Mouse1.26255407
60TBX3_20139965_ChIP-Seq_MESCs_Mouse1.25348446
61SOX2_19829295_ChIP-Seq_ESCs_Human1.24992402
62NANOG_19829295_ChIP-Seq_ESCs_Human1.24992402
63TCF4_22108803_ChIP-Seq_LS180_Human1.24655346
64SMAD4_21741376_ChIP-Seq_HESCs_Human1.23951356
65RUNX2_22187159_ChIP-Seq_PCA_Human1.23215778
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22887312
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22635958
68CBP_20019798_ChIP-Seq_JUKART_Human1.22635958
69TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.22377098
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21593595
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17387151
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.17166719
73TCF4_23295773_ChIP-Seq_U87_Human1.16077553
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14807080
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.14150114
76SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14139633
77REST_21632747_ChIP-Seq_MESCs_Mouse1.12370095
78TP53_22573176_ChIP-Seq_HFKS_Human1.12355875
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12215613
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11678121
81SMAD3_21741376_ChIP-Seq_HESCs_Human1.11585190
82SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11357876
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10970144
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10308068
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10266487
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09898727
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09672768
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08376614
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06938902
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06268004
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.06183566
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04854002
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04238105
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.03901040
95STAT3_23295773_ChIP-Seq_U87_Human1.03860872
96TP53_18474530_ChIP-ChIP_U2OS_Human1.03519889
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03510390
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01953961
99JUN_21703547_ChIP-Seq_K562_Human1.01239714
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00926681

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ5.77515024
2MP0002102_abnormal_ear_morphology4.47465330
3MP0001984_abnormal_olfaction4.15305721
4MP0005394_taste/olfaction_phenotype3.49595526
5MP0005499_abnormal_olfactory_system3.49595526
6MP0001529_abnormal_vocalization3.32041406
7MP0005367_renal/urinary_system_phenotyp2.86798068
8MP0000516_abnormal_urinary_system2.86798068
9MP0006054_spinal_hemorrhage2.80987051
10MP0001485_abnormal_pinna_reflex2.51738505
11MP0003880_abnormal_central_pattern2.33969142
12MP0000462_abnormal_digestive_system2.30861326
13MP0002837_dystrophic_cardiac_calcinosis2.28558585
14MP0002254_reproductive_system_inflammat2.17017630
15MP0008789_abnormal_olfactory_epithelium2.06713487
16MP0003011_delayed_dark_adaptation1.84747232
17MP0005084_abnormal_gallbladder_morpholo1.81207286
18MP0003119_abnormal_digestive_system1.78824087
19MP0003122_maternal_imprinting1.78796379
20MP0002938_white_spotting1.75133111
21MP0002234_abnormal_pharynx_morphology1.74153928
22MP0002163_abnormal_gland_morphology1.73401575
23MP0001486_abnormal_startle_reflex1.66775951
24MP0005379_endocrine/exocrine_gland_phen1.62314302
25MP0004133_heterotaxia1.58760033
26MP0003890_abnormal_embryonic-extraembry1.57655974
27MP0002751_abnormal_autonomic_nervous1.50186214
28MP0000538_abnormal_urinary_bladder1.45802899
29MP0000372_irregular_coat_pigmentation1.43974808
30MP0005551_abnormal_eye_electrophysiolog1.42583430
31MP0000049_abnormal_middle_ear1.39489646
32MP0003136_yellow_coat_color1.38740049
33MP0004145_abnormal_muscle_electrophysio1.38174078
34MP0006292_abnormal_olfactory_placode1.38061390
35MP0001293_anophthalmia1.37159970
36MP0005253_abnormal_eye_physiology1.36971630
37MP0002734_abnormal_mechanical_nocicepti1.35763828
38MP0004142_abnormal_muscle_tone1.34091398
39MP0003195_calcinosis1.31563820
40MP0004885_abnormal_endolymph1.28942227
41MP0009384_cardiac_valve_regurgitation1.28224030
42MP0009697_abnormal_copulation1.28210498
43MP0008058_abnormal_DNA_repair1.27348434
44MP0002009_preneoplasia1.25159856
45MP0001286_abnormal_eye_development1.23853272
46MP0008877_abnormal_DNA_methylation1.18742435
47MP0004215_abnormal_myocardial_fiber1.16267361
48MP0003121_genomic_imprinting1.15679738
49MP0003787_abnormal_imprinting1.13809458
50MP0008872_abnormal_physiological_respon1.13151372
51MP0009046_muscle_twitch1.11637003
52MP0001970_abnormal_pain_threshold1.11605398
53MP0003137_abnormal_impulse_conducting1.11332447
54MP0008004_abnormal_stomach_pH1.10229946
55MP0003567_abnormal_fetal_cardiomyocyte1.05821878
56MP0001879_abnormal_lymphatic_vessel1.04648527
57MP0001188_hyperpigmentation1.04497298
58MP0002233_abnormal_nose_morphology1.04245408
59MP0001986_abnormal_taste_sensitivity1.03605515
60MP0004510_myositis1.02047402
61MP0004147_increased_porphyrin_level1.01604497
62MP0005645_abnormal_hypothalamus_physiol1.00724315
63MP0005187_abnormal_penis_morphology1.00714924
64MP0000427_abnormal_hair_cycle0.99121070
65MP0002638_abnormal_pupillary_reflex0.98409428
66MP0001324_abnormal_eye_pigmentation0.97250079
67MP0005386_behavior/neurological_phenoty0.97022794
68MP0004924_abnormal_behavior0.97022794
69MP0003279_aneurysm0.95213790
70MP0002733_abnormal_thermal_nociception0.94754015
71MP0002736_abnormal_nociception_after0.94382975
72MP0006276_abnormal_autonomic_nervous0.93548771
73MP0004085_abnormal_heartbeat0.90702665
74MP0001270_distended_abdomen0.90140113
75MP0002272_abnormal_nervous_system0.90138277
76MP0000631_abnormal_neuroendocrine_gland0.89314283
77MP0002752_abnormal_somatic_nervous0.88306872
78MP0005391_vision/eye_phenotype0.87318596
79MP0010030_abnormal_orbit_morphology0.82548692
80MP0000470_abnormal_stomach_morphology0.82437712
81MP0002184_abnormal_innervation0.80603733
82MP0005195_abnormal_posterior_eye0.80136098
83MP0005167_abnormal_blood-brain_barrier0.78807519
84MP0002572_abnormal_emotion/affect_behav0.77873788
85MP0005075_abnormal_melanosome_morpholog0.77642322
86MP0001968_abnormal_touch/_nociception0.77548589
87MP0002557_abnormal_social/conspecific_i0.77537459
88MP0006072_abnormal_retinal_apoptosis0.77329887
89MP0000537_abnormal_urethra_morphology0.74528073
90MP0002697_abnormal_eye_size0.70318899
91MP0002735_abnormal_chemical_nociception0.70316521
92MP0000465_gastrointestinal_hemorrhage0.67873630
93MP0000026_abnormal_inner_ear0.67386298
94MP0005332_abnormal_amino_acid0.65307907
95MP0001963_abnormal_hearing_physiology0.63762090
96MP0005670_abnormal_white_adipose0.63547593
97MP0000534_abnormal_ureter_morphology0.63145234
98MP0004270_analgesia0.62964500
99MP0001944_abnormal_pancreas_morphology0.62102848
100MP0000778_abnormal_nervous_system0.61991064

Predicted human phenotypes

RankGene SetZ-score
1Congenital malformation of the right heart (HP:0011723)3.95835577
2Double outlet right ventricle (HP:0001719)3.95835577
3Intestinal atresia (HP:0011100)3.77905342
4Methylmalonic acidemia (HP:0002912)3.72433182
5Hypothermia (HP:0002045)3.68247272
6Disproportionate short-trunk short stature (HP:0003521)3.65238333
7Prominent supraorbital ridges (HP:0000336)3.39983919
8Aplastic anemia (HP:0001915)3.36326270
9Poor suck (HP:0002033)3.17681850
103-Methylglutaconic aciduria (HP:0003535)3.15333308
11Methylmalonic aciduria (HP:0012120)3.11021809
12Abnormality of homocysteine metabolism (HP:0010919)3.06596307
13Homocystinuria (HP:0002156)3.06596307
14Aplasia/Hypoplasia of the hallux (HP:0008362)2.98701579
15Medial flaring of the eyebrow (HP:0010747)2.96659584
16Short hallux (HP:0010109)2.95460581
17Polyphagia (HP:0002591)2.91880585
18Abnormality of the labia minora (HP:0012880)2.88490704
19Limb dystonia (HP:0002451)2.87120635
20Nausea (HP:0002018)2.82459109
21Abnormality of vitamin B metabolism (HP:0004340)2.74764029
22Preaxial foot polydactyly (HP:0001841)2.68118972
23Absent/shortened dynein arms (HP:0200106)2.63122291
24Dynein arm defect of respiratory motile cilia (HP:0012255)2.63122291
25Rectovaginal fistula (HP:0000143)2.62079076
26Rectal fistula (HP:0100590)2.62079076
27Abnormality of the fovea (HP:0000493)2.62071934
28Aplasia/Hypoplasia of the fovea (HP:0008060)2.61430636
29Hypoplasia of the fovea (HP:0007750)2.61430636
30Bony spicule pigmentary retinopathy (HP:0007737)2.58984407
31Abnormality of the vitamin B12 metabolism (HP:0004341)2.54566187
32Scotoma (HP:0000575)2.48073755
33Abnormal rod and cone electroretinograms (HP:0008323)2.43324278
34Broad alveolar ridges (HP:0000187)2.39301858
35Congenital, generalized hypertrichosis (HP:0004540)2.39089716
36Abdominal situs inversus (HP:0003363)2.37943424
37Abnormality of abdominal situs (HP:0011620)2.37943424
38Posterior subcapsular cataract (HP:0007787)2.35883781
39Bifid tongue (HP:0010297)2.35676328
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32946307
41Genital tract atresia (HP:0001827)2.29518063
42Constricted visual fields (HP:0001133)2.29053109
43Inability to walk (HP:0002540)2.23798527
44Anophthalmia (HP:0000528)2.22560253
45Failure to thrive in infancy (HP:0001531)2.22255944
46Vaginal atresia (HP:0000148)2.22115448
47Hypoplastic pelvis (HP:0008839)2.20166411
48Abnormal lung lobation (HP:0002101)2.17356253
49Large for gestational age (HP:0001520)2.16512490
50Anal stenosis (HP:0002025)2.13570270
51Abnormality of the parathyroid morphology (HP:0011766)2.12973870
52Exercise-induced muscle cramps (HP:0003710)2.10289518
53Congenital stationary night blindness (HP:0007642)2.09629550
54Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07567277
55Abolished electroretinogram (ERG) (HP:0000550)2.06578113
56Gait imbalance (HP:0002141)2.05057011
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.01881463
58Intestinal fistula (HP:0100819)1.99265422
59Septate vagina (HP:0001153)1.99233967
60Focal seizures (HP:0007359)1.99215398
61Aplasia/Hypoplasia of the macula (HP:0008059)1.98409373
62Congenital primary aphakia (HP:0007707)1.96110019
63Vaginal fistula (HP:0004320)1.95334630
64Atonic seizures (HP:0010819)1.94581904
65Abnormality of vitamin metabolism (HP:0100508)1.94247115
66Abnormality of methionine metabolism (HP:0010901)1.92790972
67Oligodactyly (hands) (HP:0001180)1.90044864
68Anencephaly (HP:0002323)1.88324903
69Aplasia/Hypoplasia affecting the retina (HP:0008061)1.87883140
70Growth hormone deficiency (HP:0000824)1.85546979
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84108477
72Cupped ear (HP:0000378)1.82529103
73Hypoplastic left heart (HP:0004383)1.82198839
74Molar tooth sign on MRI (HP:0002419)1.81449888
75Abnormality of midbrain morphology (HP:0002418)1.81449888
76Stenosis of the external auditory canal (HP:0000402)1.81065790
77Optic nerve hypoplasia (HP:0000609)1.80464688
78Anal atresia (HP:0002023)1.79670477
79Hepatocellular necrosis (HP:0001404)1.79053510
80Concave nail (HP:0001598)1.77963887
81Gastrointestinal atresia (HP:0002589)1.77636271
82Facial diplegia (HP:0001349)1.77567670
83Barrel-shaped chest (HP:0001552)1.76702720
84Attenuation of retinal blood vessels (HP:0007843)1.76173331
85Short tibia (HP:0005736)1.73382705
86Oral leukoplakia (HP:0002745)1.73071024
87Bilateral microphthalmos (HP:0007633)1.70664229
88Thin upper lip vermilion (HP:0000219)1.68752025
89Abnormal ciliary motility (HP:0012262)1.68247523
90Bicornuate uterus (HP:0000813)1.67721216
91Renal hypoplasia (HP:0000089)1.67628871
92Supernumerary spleens (HP:0009799)1.65472125
93Increased number of teeth (HP:0011069)1.65229150
94Labial hypoplasia (HP:0000066)1.65000962
95Abnormal drinking behavior (HP:0030082)1.64350341
96Polydipsia (HP:0001959)1.64350341
97Delayed puberty (HP:0000823)1.63957423
98Nephrogenic diabetes insipidus (HP:0009806)1.62093785
99Generalized aminoaciduria (HP:0002909)1.61459600
100Colon cancer (HP:0003003)1.60524150

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K27.20847181
2LATS13.95119360
3NUAK13.88113239
4STK163.10969308
5ERBB42.68460484
6WNK32.64271844
7FRK2.43207486
8TRIM282.31037315
9ACVR1B2.28472914
10STK391.90335059
11OXSR11.86952231
12MKNK21.86506347
13STK31.79906735
14PAK31.79889958
15BMPR1B1.72916528
16MST41.63264899
17TLK11.62605001
18BCR1.53118883
19WEE11.52072924
20PNCK1.51421323
21GRK11.46412799
22FLT31.44962996
23INSRR1.44368106
24TNIK1.41753509
25MAPK131.38560870
26EPHA31.36511974
27MARK11.33620613
28ERBB31.29853455
29IRAK11.29666683
30MKNK11.29254845
31IRAK21.18244259
32DYRK31.17579399
33DAPK21.14198413
34CASK1.14023018
35MAPK151.13941480
36PBK1.06141273
37MAP3K41.00953719
38ADRBK20.99020424
39MAP3K90.98606165
40ICK0.98516324
41PRKCE0.97576665
42PRKCG0.97547704
43KIT0.95425796
44MAP2K60.94379395
45BCKDK0.92932214
46TSSK60.91684233
47CSNK1G20.89326014
48ILK0.89053499
49PRKD30.86655242
50DYRK20.84311594
51STK38L0.77812200
52NEK10.73634229
53PLK20.71539384
54ADRBK10.70593703
55EPHB20.69733571
56MAP2K70.67854308
57CSNK1G30.66345781
58EIF2AK30.63332402
59SIK30.61366877
60CSNK1A1L0.61210420
61PLK40.60428582
62NLK0.58425210
63WNK40.58179247
64STK240.57841159
65TGFBR10.56845673
66PHKG20.52029942
67PHKG10.52029942
68PRKG10.51216407
69TEC0.50997062
70CSNK1G10.48680785
71CDK30.47891808
72PLK30.47331684
73CAMK2A0.46459838
74PINK10.41155495
75CDK70.37573896
76FER0.36942474
77ABL10.35741296
78AKT30.32900881
79PIK3CG0.31562324
80EIF2AK10.30951068
81ARAF0.29746638
82IKBKE0.28712147
83RPS6KA40.28067312
84MAP3K60.27753874
85PRKCQ0.27708206
86PKN20.26814150
87CAMK2D0.26412456
88RAF10.25996821
89MINK10.25379544
90GRK70.24677181
91KDR0.24516467
92PRKCB0.22972969
93EPHA40.20655052
94PLK10.19290413
95MYLK0.18989909
96CSNK2A20.18867331
97DDR20.18550969
98PRKACA0.18316056
99PRKCH0.17841158
100PRKCA0.17251912

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.32255447
2Olfactory transduction_Homo sapiens_hsa047402.60061279
3Oxidative phosphorylation_Homo sapiens_hsa001902.59285883
4Phototransduction_Homo sapiens_hsa047442.49222855
5Nicotine addiction_Homo sapiens_hsa050332.46235739
6Parkinsons disease_Homo sapiens_hsa050122.43805748
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13513586
8Propanoate metabolism_Homo sapiens_hsa006402.10810853
9RNA degradation_Homo sapiens_hsa030182.06349261
10Selenocompound metabolism_Homo sapiens_hsa004502.04522057
11Butanoate metabolism_Homo sapiens_hsa006502.01830099
12Serotonergic synapse_Homo sapiens_hsa047261.99465307
13Sulfur metabolism_Homo sapiens_hsa009201.93235670
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90771677
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.80805366
16RNA polymerase_Homo sapiens_hsa030201.79445327
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.78800147
18Morphine addiction_Homo sapiens_hsa050321.68454416
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67206243
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.64395728
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63892569
22Basal transcription factors_Homo sapiens_hsa030221.59916163
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58747296
24Renin secretion_Homo sapiens_hsa049241.47446718
25Huntingtons disease_Homo sapiens_hsa050161.47036460
26Taste transduction_Homo sapiens_hsa047421.46681985
27Alzheimers disease_Homo sapiens_hsa050101.46281824
28Purine metabolism_Homo sapiens_hsa002301.42478820
29Collecting duct acid secretion_Homo sapiens_hsa049661.41014536
30Circadian entrainment_Homo sapiens_hsa047131.30996015
31GABAergic synapse_Homo sapiens_hsa047271.26629965
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23520283
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21375428
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18747766
35Cocaine addiction_Homo sapiens_hsa050301.16321981
36Tryptophan metabolism_Homo sapiens_hsa003801.15973570
37Proteasome_Homo sapiens_hsa030501.15379939
38Linoleic acid metabolism_Homo sapiens_hsa005911.14573544
39Glutathione metabolism_Homo sapiens_hsa004801.14109880
40Cardiac muscle contraction_Homo sapiens_hsa042601.12868691
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10925950
42Fatty acid elongation_Homo sapiens_hsa000621.09014916
43ABC transporters_Homo sapiens_hsa020101.05220502
44Dopaminergic synapse_Homo sapiens_hsa047281.04859861
45Hippo signaling pathway_Homo sapiens_hsa043901.03142863
46Glutamatergic synapse_Homo sapiens_hsa047241.02103686
47Hedgehog signaling pathway_Homo sapiens_hsa043401.02074384
48Retinol metabolism_Homo sapiens_hsa008301.01204523
49Calcium signaling pathway_Homo sapiens_hsa040200.99012653
50Steroid biosynthesis_Homo sapiens_hsa001000.97877477
51Amphetamine addiction_Homo sapiens_hsa050310.95026442
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.94621724
53Regulation of autophagy_Homo sapiens_hsa041400.92498872
54cAMP signaling pathway_Homo sapiens_hsa040240.91411976
55Cholinergic synapse_Homo sapiens_hsa047250.88810542
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88284063
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87852503
58Basal cell carcinoma_Homo sapiens_hsa052170.87499718
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85248969
60Caffeine metabolism_Homo sapiens_hsa002320.84676476
61Ribosome_Homo sapiens_hsa030100.84294521
62p53 signaling pathway_Homo sapiens_hsa041150.82763130
63TGF-beta signaling pathway_Homo sapiens_hsa043500.82282549
64Ether lipid metabolism_Homo sapiens_hsa005650.80528582
65Chemical carcinogenesis_Homo sapiens_hsa052040.79092737
66beta-Alanine metabolism_Homo sapiens_hsa004100.74906197
67Vitamin digestion and absorption_Homo sapiens_hsa049770.73668664
68Wnt signaling pathway_Homo sapiens_hsa043100.71765158
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.70780700
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69074857
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69028505
72Axon guidance_Homo sapiens_hsa043600.66702178
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63392606
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63330234
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62124182
76Salivary secretion_Homo sapiens_hsa049700.60400396
77Type I diabetes mellitus_Homo sapiens_hsa049400.58808812
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55720304
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55159391
80Long-term depression_Homo sapiens_hsa047300.52740345
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52653732
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52498546
83Oocyte meiosis_Homo sapiens_hsa041140.52317789
84Peroxisome_Homo sapiens_hsa041460.50986235
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46143654
86Ovarian steroidogenesis_Homo sapiens_hsa049130.45818384
87Gap junction_Homo sapiens_hsa045400.45141893
88Oxytocin signaling pathway_Homo sapiens_hsa049210.44235554
89Fat digestion and absorption_Homo sapiens_hsa049750.43681920
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42837139
91Metabolic pathways_Homo sapiens_hsa011000.41647833
92Gastric acid secretion_Homo sapiens_hsa049710.40256486
93Rheumatoid arthritis_Homo sapiens_hsa053230.40089001
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37010760
95Insulin secretion_Homo sapiens_hsa049110.35768240
96RNA transport_Homo sapiens_hsa030130.34458497
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32282145
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32170428
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31334047
100Asthma_Homo sapiens_hsa053100.31226897

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