BECN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.58561341
2COPI coating of Golgi vesicle (GO:0048205)6.58561341
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.37867374
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.37867374
5antigen processing and presentation of endogenous antigen (GO:0019883)5.71678301
6positive regulation of gamma-delta T cell activation (GO:0046645)4.40362826
7negative regulation of cell killing (GO:0031342)4.09514013
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.09514013
9regulation of gamma-delta T cell differentiation (GO:0045586)3.98317316
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.92606065
11retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.86936256
12regulation of regulatory T cell differentiation (GO:0045589)3.68210797
13protein retention in ER lumen (GO:0006621)3.67289140
14positive regulation of lamellipodium assembly (GO:0010592)3.65929754
15regulation of gamma-delta T cell activation (GO:0046643)3.57449392
16neutrophil activation involved in immune response (GO:0002283)3.56359412
17Arp2/3 complex-mediated actin nucleation (GO:0034314)3.46751181
18regulation of translational termination (GO:0006449)3.42562719
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.42204945
20antigen processing and presentation via MHC class Ib (GO:0002475)3.38077566
21activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.34786492
22tricarboxylic acid metabolic process (GO:0072350)3.34077176
23negative thymic T cell selection (GO:0045060)3.33632145
24positive regulation of nuclease activity (GO:0032075)3.31507766
25regulation of RIG-I signaling pathway (GO:0039535)3.27614204
26oxaloacetate metabolic process (GO:0006107)3.25635625
27positive regulation of histone deacetylation (GO:0031065)3.25451971
28cytidine deamination (GO:0009972)3.25121264
29cytidine metabolic process (GO:0046087)3.25121264
30cytidine catabolic process (GO:0006216)3.25121264
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22977676
32negative T cell selection (GO:0043383)3.16101996
33vesicle coating (GO:0006901)3.10737060
34negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.06277516
35positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.06092396
36positive regulation of lamellipodium organization (GO:1902745)3.04685445
37pyrimidine ribonucleoside catabolic process (GO:0046133)3.03967143
38regulation of chronic inflammatory response (GO:0002676)3.03568735
39regulation of nuclease activity (GO:0032069)3.01459884
40protein autoprocessing (GO:0016540)3.00160516
41positive regulation of T cell mediated cytotoxicity (GO:0001916)2.96087383
42regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.95578321
43regulation of B cell receptor signaling pathway (GO:0050855)2.94028720
44positive thymic T cell selection (GO:0045059)2.93891665
45regulation of response to interferon-gamma (GO:0060330)2.89939168
46regulation of T cell mediated cytotoxicity (GO:0001914)2.89510841
47JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.88696474
48positive regulation of B cell differentiation (GO:0045579)2.87548275
49response to interferon-beta (GO:0035456)2.86235004
50pentose-phosphate shunt (GO:0006098)2.86014533
51regulation of interleukin-12 biosynthetic process (GO:0045075)2.85008326
52endoplasmic reticulum unfolded protein response (GO:0030968)2.84177209
53regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.83350677
54regulation of alpha-beta T cell proliferation (GO:0046640)2.82776541
55neutrophil activation (GO:0042119)2.81892935
56negative regulation of T-helper cell differentiation (GO:0045623)2.81622682
57negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.81622682
58positive regulation of granulocyte differentiation (GO:0030854)2.79778023
59negative regulation of T cell apoptotic process (GO:0070233)2.76201509
60barbed-end actin filament capping (GO:0051016)2.75034411
61regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.74148567
62cellular response to unfolded protein (GO:0034620)2.73740760
63cellular response to type I interferon (GO:0071357)2.73120901
64type I interferon signaling pathway (GO:0060337)2.73120901
65immunoglobulin mediated immune response (GO:0016064)2.70531418
66granulocyte activation (GO:0036230)2.70506996
67positive regulation of protein deacetylation (GO:0090312)2.70289246
68thymic T cell selection (GO:0045061)2.69980834
69response to type I interferon (GO:0034340)2.69710765
70necroptotic process (GO:0070266)2.69259646
71tolerance induction (GO:0002507)2.68743311
72positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.67906541
73positive regulation of alpha-beta T cell proliferation (GO:0046641)2.67569083
74response to interleukin-15 (GO:0070672)2.67045114
75positive regulation of macrophage differentiation (GO:0045651)2.67006766
76negative regulation of erythrocyte differentiation (GO:0045647)2.66795865
77negative regulation of interleukin-12 production (GO:0032695)2.65907631
78cellular response to topologically incorrect protein (GO:0035967)2.65494934
79regulation of leukocyte mediated cytotoxicity (GO:0001910)2.64753465
80regulation of defense response to virus by virus (GO:0050690)2.64667384
81regulation of B cell differentiation (GO:0045577)2.63898159
82COPII vesicle coating (GO:0048208)2.63711383
83protein maturation by protein folding (GO:0022417)2.63219524
84negative regulation of thymocyte apoptotic process (GO:0070244)2.63024424
85actin nucleation (GO:0045010)2.61479169
86ER-nucleus signaling pathway (GO:0006984)2.58449926
87sexual reproduction (GO:0019953)2.58190319
88negative regulation of cell size (GO:0045792)2.56986281
89natural killer cell differentiation (GO:0001779)2.56860694
90dendritic cell chemotaxis (GO:0002407)2.56362400
91organelle membrane fusion (GO:0090174)2.56087352
92positive regulation of B cell mediated immunity (GO:0002714)2.55484404
93positive regulation of immunoglobulin mediated immune response (GO:0002891)2.55484404
94regulation of natural killer cell mediated immunity (GO:0002715)2.55381920
95regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.55381920
96signal peptide processing (GO:0006465)2.54807464
97lymphocyte chemotaxis (GO:0048247)2.53762767
98T cell migration (GO:0072678)2.52189962
99B cell mediated immunity (GO:0019724)2.51818425
1002-oxoglutarate metabolic process (GO:0006103)2.51614918
101NIK/NF-kappaB signaling (GO:0038061)2.50229532
102regulation of T cell receptor signaling pathway (GO:0050856)2.47845398
103negative regulation of T cell mediated immunity (GO:0002710)2.46984795
104T cell apoptotic process (GO:0070231)2.46743144
105NADH metabolic process (GO:0006734)2.46231218
106antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.45506762
107negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.45330919
108interferon-gamma production (GO:0032609)2.45158121
109positive regulation of tolerance induction (GO:0002645)2.44639482
110antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.44283048
111dendritic cell migration (GO:0036336)2.43303045
112positive regulation of defense response to virus by host (GO:0002230)2.43198576
113autophagic vacuole fusion (GO:0000046)2.40591920
114regulation of germinal center formation (GO:0002634)2.39255897
115positive regulation of humoral immune response (GO:0002922)2.38299255
116negative regulation of lymphocyte mediated immunity (GO:0002707)2.37957753
117NADPH regeneration (GO:0006740)2.37791406
118negative regulation of glycoprotein biosynthetic process (GO:0010561)2.37582681
119regulation of oxidative stress-induced neuron death (GO:1903203)2.36705903
120T cell selection (GO:0045058)2.36325805
121regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.35933887
122execution phase of apoptosis (GO:0097194)2.35698962
123negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.35482018
124interferon-gamma-mediated signaling pathway (GO:0060333)2.34083510
125regulation of tolerance induction (GO:0002643)2.33760825
126regulation of protein heterodimerization activity (GO:0043497)2.33004420
127regulation of cell killing (GO:0031341)2.32682015
128maternal placenta development (GO:0001893)2.32402472
129regulation of metalloenzyme activity (GO:0048552)2.31504468
130positive regulation of cell killing (GO:0031343)2.31449829
131leukocyte degranulation (GO:0043299)2.31444478
132positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.31375111
133positive regulation of T cell mediated immunity (GO:0002711)2.28945734
134positive regulation of natural killer cell mediated immunity (GO:0002717)2.28391523
135morphogenesis of an endothelium (GO:0003159)2.28316897
136endothelial tube morphogenesis (GO:0061154)2.28316897
137thrombin receptor signaling pathway (GO:0070493)2.28201754
138antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.27742591
139galactose catabolic process (GO:0019388)2.27582502
140regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.26732915
141negative regulation of viral genome replication (GO:0045071)2.26635662
142pyrimidine nucleoside catabolic process (GO:0046135)2.25846419
143positive regulation of DNA recombination (GO:0045911)2.24978669
144positive regulation of T cell cytokine production (GO:0002726)2.24376026
145negative regulation of leukocyte mediated immunity (GO:0002704)2.24359780
146positive T cell selection (GO:0043368)2.24343727
147virion assembly (GO:0019068)2.24249920
148membrane raft organization (GO:0031579)2.23602509
149cellular response to zinc ion (GO:0071294)2.23427813
150platelet aggregation (GO:0070527)2.22925396
151lysine catabolic process (GO:0006554)2.22888934
152lysine metabolic process (GO:0006553)2.22888934
153fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.22454017
154regulation of type I interferon-mediated signaling pathway (GO:0060338)2.22448763
155positive regulation of T cell chemotaxis (GO:0010820)2.21668703
156regulation of T cell chemotaxis (GO:0010819)2.21668703
157T cell costimulation (GO:0031295)2.21558497
158lymphocyte costimulation (GO:0031294)2.21529446
159positive regulation of isotype switching (GO:0045830)2.21256131
160sequestering of metal ion (GO:0051238)2.21075949
161valine metabolic process (GO:0006573)2.21043586
162regulation of T cell tolerance induction (GO:0002664)2.17207084
163L-alpha-amino acid transmembrane transport (GO:1902475)2.16632795
164ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.15629229
165hepatocyte apoptotic process (GO:0097284)2.15124810
166mannose metabolic process (GO:0006013)2.14408122
167DNA deamination (GO:0045006)2.14112706
168T cell proliferation (GO:0042098)2.14070245
169cellular response to interleukin-15 (GO:0071350)2.14012907
170positive regulation of immune response to tumor cell (GO:0002839)2.13842568
171regulation of immune response to tumor cell (GO:0002837)2.13842568
172regulation of response to tumor cell (GO:0002834)2.13842568
173positive regulation of response to tumor cell (GO:0002836)2.13842568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.22759154
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.07678480
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.02423121
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.00883107
5GATA1_22025678_ChIP-Seq_K562_Human2.87748183
6MYC_22102868_ChIP-Seq_BL_Human2.86077731
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.83451467
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.77283706
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.65311049
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.35755953
11VDR_21846776_ChIP-Seq_THP-1_Human2.30797338
12E2F7_22180533_ChIP-Seq_HELA_Human2.28403335
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.15605059
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11916601
15ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01509397
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98587267
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.96959806
18MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96881762
19MAF_26560356_Chip-Seq_TH1_Human1.96374126
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.94661549
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92520284
22CLOCK_20551151_ChIP-Seq_293T_Human1.91173556
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90761751
24MYB_26560356_Chip-Seq_TH2_Human1.90355526
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.88801271
26TCF7_22412390_ChIP-Seq_EML_Mouse1.88468787
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87166584
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.84837229
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84102628
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81175951
31* GATA3_26560356_Chip-Seq_TH2_Human1.80741093
32UTX_26944678_Chip-Seq_JUKART_Human1.80729855
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77084942
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75001704
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.74010412
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.71516114
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.70285323
38ZNF263_19887448_ChIP-Seq_K562_Human1.69377152
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.68823304
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67329478
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65472278
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65241184
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63152571
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.60034859
45MYB_26560356_Chip-Seq_TH1_Human1.60003721
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59789746
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58720446
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57699014
49SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56596201
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56460295
51* SPI1_23547873_ChIP-Seq_NB4_Human1.55643676
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55427151
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55308077
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.53560128
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.53216498
56VDR_24763502_ChIP-Seq_THP-1_Human1.51061684
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.49831546
58KDM2B_26808549_Chip-Seq_DND41_Human1.49472599
59LXR_22292898_ChIP-Seq_THP-1_Human1.48185407
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.46809988
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45484386
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44953780
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44860211
64* TFEB_21752829_ChIP-Seq_HELA_Human1.44292618
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43892847
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43560103
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43514785
68* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41804331
69SCL_19346495_ChIP-Seq_HPC-7_Human1.41598850
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40971310
71* VDR_23849224_ChIP-Seq_CD4+_Human1.40809445
72* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40376425
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.40103174
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38423962
75ATF3_27146783_Chip-Seq_COLON_Human1.38364485
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37652701
77* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37009245
78IRF8_27001747_Chip-Seq_BMDM_Mouse1.33342423
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32530860
80GATA3_27048872_Chip-Seq_THYMUS_Human1.31006965
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30623160
82FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.30299737
83SPI1_23127762_ChIP-Seq_K562_Human1.30204152
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26611550
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25147674
86GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24787051
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.24333036
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.24215986
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24134904
90CIITA_25753668_ChIP-Seq_RAJI_Human1.22723752
91* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21780970
92RXR_22158963_ChIP-Seq_LIVER_Mouse1.20855140
93MAF_26560356_Chip-Seq_TH2_Human1.20127459
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.19108068
95* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16866972
96EST1_17652178_ChIP-ChIP_JURKAT_Human1.14608489
97RUNX_20019798_ChIP-Seq_JUKART_Human1.13724284
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11883565
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11850515
100CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11124006
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09624958
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09416328
103ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08650826
104CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07032961
105GATA1_19941826_ChIP-Seq_K562_Human1.06659658
106* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06419490
107* GABP_19822575_ChIP-Seq_HepG2_Human1.06285746
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05529068
109GATA1_19941827_ChIP-Seq_MEL_Mouse1.04350620
110* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02826732
111ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02371980
112KDM5A_27292631_Chip-Seq_BREAST_Human1.00760768
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98481409
114NCOR1_26117541_ChIP-Seq_K562_Human0.98391368
115RACK7_27058665_Chip-Seq_MCF-7_Human0.98283618
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98275563
117* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98017013
118BCL6_27268052_Chip-Seq_Bcells_Human0.97725377
119PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95351239
120JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95182591
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94977963
122RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94904336
123FOXP3_21729870_ChIP-Seq_TREG_Human0.94221148
124XRN2_22483619_ChIP-Seq_HELA_Human0.93409909
125GATA4_25053715_ChIP-Seq_YYC3_Human0.92655970
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92126619
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90780556
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90759897
129PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90745532
130SOX2_20726797_ChIP-Seq_SW620_Human0.90578890
131CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90081652
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89441790
133FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88984392
134PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88957622
135PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88704202
136VDR_24787735_ChIP-Seq_THP-1_Human0.88195986
137PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86700314
138TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85366131
139PU_27001747_Chip-Seq_BMDM_Mouse0.84339473
140GATA3_26560356_Chip-Seq_TH1_Human0.83851930
141RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83072518
142ELK1_19687146_ChIP-ChIP_HELA_Human0.82898271
143PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82740960
144SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82000958
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81740649
146STAT1_20625510_ChIP-Seq_HELA_Human0.81593099
147PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81314937
148LXR_22158963_ChIP-Seq_LIVER_Mouse0.81238653
149AR_20517297_ChIP-Seq_VCAP_Human0.80735292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism3.23580670
2MP0003705_abnormal_hypodermis_morpholog2.93146602
3MP0003300_gastrointestinal_ulcer2.75315563
4MP0010234_abnormal_vibrissa_follicle2.63525311
5MP0006054_spinal_hemorrhage2.48152920
6MP0001835_abnormal_antigen_presentation2.45716183
7MP0003436_decreased_susceptibility_to2.42528036
8MP0003191_abnormal_cellular_cholesterol2.31210708
9MP0002166_altered_tumor_susceptibility2.20989576
10MP0005360_urolithiasis2.18451614
11* MP0000685_abnormal_immune_system2.09492729
12MP0003763_abnormal_thymus_physiology2.08934178
13MP0003806_abnormal_nucleotide_metabolis2.05703665
14MP0006082_CNS_inflammation2.04269160
15MP0010352_gastrointestinal_tract_polyps2.03617985
16MP0008961_abnormal_basal_metabolism2.02710487
17MP0002909_abnormal_adrenal_gland2.02008325
18MP0005451_abnormal_body_composition1.91672810
19MP0003656_abnormal_erythrocyte_physiolo1.81172462
20MP0003195_calcinosis1.79912661
21MP0001800_abnormal_humoral_immune1.72347894
22MP0000013_abnormal_adipose_tissue1.72268694
23MP0003866_abnormal_defecation1.69716664
24MP0004947_skin_inflammation1.67519854
25MP0002138_abnormal_hepatobiliary_system1.66408952
26MP0000465_gastrointestinal_hemorrhage1.64679580
27MP0002398_abnormal_bone_marrow1.64438272
28MP0005000_abnormal_immune_tolerance1.63129137
29MP0005671_abnormal_response_to1.60606089
30MP0009785_altered_susceptibility_to1.58749416
31MP0002877_abnormal_melanocyte_morpholog1.57802052
32MP0001853_heart_inflammation1.56768069
33MP0002420_abnormal_adaptive_immunity1.56447326
34MP0002006_tumorigenesis1.56176307
35MP0003303_peritoneal_inflammation1.55037253
36MP0001819_abnormal_immune_cell1.54972476
37MP0002452_abnormal_antigen_presenting1.53893479
38MP0002723_abnormal_immune_serum1.50831165
39MP0005464_abnormal_platelet_physiology1.50495235
40MP0009780_abnormal_chondrocyte_physiolo1.49268252
41MP0001545_abnormal_hematopoietic_system1.48719441
42MP0005397_hematopoietic_system_phenotyp1.48719441
43MP0005058_abnormal_lysosome_morphology1.48176509
44MP0004808_abnormal_hematopoietic_stem1.47914426
45MP0010155_abnormal_intestine_physiology1.47735067
46MP0001790_abnormal_immune_system1.46121228
47MP0005387_immune_system_phenotype1.46121228
48MP0009764_decreased_sensitivity_to1.45852250
49MP0005025_abnormal_response_to1.45252589
50MP0006036_abnormal_mitochondrial_physio1.43549695
51MP0009278_abnormal_bone_marrow1.35449666
52MP0005365_abnormal_bile_salt1.35323749
53MP0001533_abnormal_skeleton_physiology1.33459413
54MP0000716_abnormal_immune_system1.30412682
55MP0002396_abnormal_hematopoietic_system1.30375548
56MP0001845_abnormal_inflammatory_respons1.30023742
57MP0001873_stomach_inflammation1.28845606
58MP0001756_abnormal_urination1.28777697
59MP0005083_abnormal_biliary_tract1.28420396
60MP0002419_abnormal_innate_immunity1.27024499
61MP0000604_amyloidosis1.26464984
62MP0005076_abnormal_cell_differentiation1.25681488
63MP0002722_abnormal_immune_system1.25654547
64MP0000343_altered_response_to1.25391606
65MP0002405_respiratory_system_inflammati1.24482062
66* MP0000689_abnormal_spleen_morphology1.24190881
67MP0005408_hypopigmentation1.23606316
68MP0002429_abnormal_blood_cell1.22161500
69MP0000569_abnormal_digit_pigmentation1.22080852
70MP0003045_fibrosis1.21494683
71MP0001666_abnormal_nutrient_absorption1.21482658
72MP0009643_abnormal_urine_homeostasis1.20742187
73MP0005075_abnormal_melanosome_morpholog1.20626309
74MP0005085_abnormal_gallbladder_physiolo1.20273252
75MP0000858_altered_metastatic_potential1.18494017
76MP0003828_pulmonary_edema1.18396123
77MP0003172_abnormal_lysosome_physiology1.16212506
78MP0010307_abnormal_tumor_latency1.15795228
79MP0009840_abnormal_foam_cell1.15483039
80MP0005165_increased_susceptibility_to1.15038357
81MP0000609_abnormal_liver_physiology1.14635415
82MP0002139_abnormal_hepatobiliary_system1.14285281
83MP0002132_abnormal_respiratory_system1.14150082
84MP0000703_abnormal_thymus_morphology1.13856746
85MP0009763_increased_sensitivity_to1.13405271
86MP0005166_decreased_susceptibility_to1.11701350
87MP0008004_abnormal_stomach_pH1.10563736
88MP0008875_abnormal_xenobiotic_pharmacok1.10253272
89MP0005310_abnormal_salivary_gland1.09421479
90MP0009333_abnormal_splenocyte_physiolog1.09395794
91MP0002837_dystrophic_cardiac_calcinosis1.08235021
92MP0004264_abnormal_extraembryonic_tissu1.07185779
93MP0008469_abnormal_protein_level1.06759979
94MP0003950_abnormal_plasma_membrane1.06173102
95MP0000372_irregular_coat_pigmentation1.04567414
96MP0000358_abnormal_cell_content/1.03950789
97MP0003693_abnormal_embryo_hatching1.03816467
98MP0002933_joint_inflammation1.03718179
99MP0005023_abnormal_wound_healing1.03166854
100MP0004381_abnormal_hair_follicle1.02803298
101MP0001765_abnormal_ion_homeostasis1.02386775
102MP0003724_increased_susceptibility_to1.01486205
103MP0000015_abnormal_ear_pigmentation1.00941794
104MP0002148_abnormal_hypersensitivity_rea1.00657530
105MP0004883_abnormal_blood_vessel0.98250000
106MP0005220_abnormal_exocrine_pancreas0.98023788
107MP0003566_abnormal_cell_adhesion0.95855715
108MP0000490_abnormal_crypts_of0.95800221
109MP0002693_abnormal_pancreas_physiology0.95381483
110MP0003646_muscle_fatigue0.94970823
111MP0003091_abnormal_cell_migration0.94895096
112MP0002277_abnormal_respiratory_mucosa0.94689481
113MP0001944_abnormal_pancreas_morphology0.93568826
114MP0002136_abnormal_kidney_physiology0.92760843
115MP0004510_myositis0.92390938
116MP0005164_abnormal_response_to0.92120562
117MP0005636_abnormal_mineral_homeostasis0.92022705
118MP0005319_abnormal_enzyme/_coenzyme0.90686550
119MP0003075_altered_response_to0.90031509
120MP0005584_abnormal_enzyme/coenzyme_acti0.88629293
121MP0002332_abnormal_exercise_endurance0.87534782
122MP0002876_abnormal_thyroid_physiology0.87186258
123* MP0002019_abnormal_tumor_incidence0.85264043
124MP0006035_abnormal_mitochondrial_morpho0.84129591
125MP0003329_amyloid_beta_deposits0.84055705
126MP0004036_abnormal_muscle_relaxation0.82458840
127MP0003252_abnormal_bile_duct0.81898373
128MP0005084_abnormal_gallbladder_morpholo0.80400761
129MP0000249_abnormal_blood_vessel0.80399828
130MP0002078_abnormal_glucose_homeostasis0.80139449
131MP0003448_altered_tumor_morphology0.80059078
132MP0010329_abnormal_lipoprotein_level0.79317137
133MP0003186_abnormal_redox_activity0.78637297
134MP0001764_abnormal_homeostasis0.76667069
135MP0001663_abnormal_digestive_system0.75802001
136MP0004484_altered_response_of0.72803181

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)3.62347865
2Recurrent bronchitis (HP:0002837)3.48583426
3Prolonged bleeding time (HP:0003010)3.29452738
4IgM deficiency (HP:0002850)3.20929417
5Purpura (HP:0000979)3.19765825
6Petechiae (HP:0000967)3.18031410
7Elevated erythrocyte sedimentation rate (HP:0003565)3.17425293
8Long toe (HP:0010511)3.11929167
9Nasal polyposis (HP:0100582)3.05425151
10IgG deficiency (HP:0004315)3.04737293
11Recurrent abscess formation (HP:0002722)2.93307446
12Abnormality of the nasal mucosa (HP:0000433)2.90457546
13Hand muscle atrophy (HP:0009130)2.88664602
14Increased IgM level (HP:0003496)2.87781243
15Abnormality of macrophages (HP:0004311)2.82330619
16Chronic diarrhea (HP:0002028)2.80899897
17Gingival bleeding (HP:0000225)2.73082075
18Menorrhagia (HP:0000132)2.72683636
19Autoimmune hemolytic anemia (HP:0001890)2.72304793
20Epistaxis (HP:0000421)2.67056720
21Recurrent bacterial skin infections (HP:0005406)2.66879431
22Dysostosis multiplex (HP:0000943)2.60184233
23Generalized aminoaciduria (HP:0002909)2.54976266
24Eosinophilia (HP:0001880)2.54604329
25Eczematoid dermatitis (HP:0000976)2.54557866
26Pulmonary infiltrates (HP:0002113)2.51819140
27Growth hormone excess (HP:0000845)2.51171499
28Hypoproteinemia (HP:0003075)2.48673593
29Urinary glycosaminoglycan excretion (HP:0003541)2.42067433
30Mucopolysacchariduria (HP:0008155)2.42067433
31Abnormality of glycolipid metabolism (HP:0010969)2.42059395
32Abnormality of liposaccharide metabolism (HP:0010968)2.42059395
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.42059395
34Thrombocytosis (HP:0001894)2.40419424
35Abnormality of the lower motor neuron (HP:0002366)2.40313080
36Autoimmune thrombocytopenia (HP:0001973)2.39478745
37Cerebral aneurysm (HP:0004944)2.38644934
38Renal cortical cysts (HP:0000803)2.35831076
39Bronchitis (HP:0012387)2.35656576
40Granulocytopenia (HP:0001913)2.34573287
41Gastrointestinal infarctions (HP:0005244)2.34279935
42Acute hepatic failure (HP:0006554)2.33353834
43Nausea (HP:0002018)2.31963084
44Upper limb amyotrophy (HP:0009129)2.31873681
45Distal upper limb amyotrophy (HP:0007149)2.31873681
46Panhypogammaglobulinemia (HP:0003139)2.30810049
47Myositis (HP:0100614)2.28248958
48Severe combined immunodeficiency (HP:0004430)2.27690321
49Hepatic necrosis (HP:0002605)2.26484024
50Abnormality of polysaccharide metabolism (HP:0011012)2.25821366
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.25821366
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.25821366
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.25321375
54Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.24930882
55Abnormal platelet volume (HP:0011876)2.24680043
56Agammaglobulinemia (HP:0004432)2.22284091
57Increased mean platelet volume (HP:0011877)2.21760295
58Encephalitis (HP:0002383)2.21350653
59Hyperlipoproteinemia (HP:0010980)2.19948054
60Retrobulbar optic neuritis (HP:0100654)2.18064689
61Optic neuritis (HP:0100653)2.18064689
62Mediastinal lymphadenopathy (HP:0100721)2.17826527
63Abnormality of eosinophils (HP:0001879)2.17732513
64Hypercortisolism (HP:0001578)2.16376018
65Papilloma (HP:0012740)2.15241470
66Verrucae (HP:0200043)2.15241470
67Tongue fasciculations (HP:0001308)2.14680912
68Recurrent skin infections (HP:0001581)2.14638548
69Muscle fibrillation (HP:0010546)2.13309944
70Abnormality of the thoracic spine (HP:0100711)2.12775251
71Abnormality of T cell number (HP:0011839)2.12368328
72Gout (HP:0001997)2.12155553
73Chronic sinusitis (HP:0011109)2.11207375
74Vacuolated lymphocytes (HP:0001922)2.11164161
75Recurrent cutaneous fungal infections (HP:0011370)2.11138188
76Chronic mucocutaneous candidiasis (HP:0002728)2.11138188
77Recurrent viral infections (HP:0004429)2.10025646
78T lymphocytopenia (HP:0005403)2.08840390
79Meningitis (HP:0001287)2.08675803
80Polygenic inheritance (HP:0010982)2.06822795
81Late onset (HP:0003584)2.06643330
82Glucose intolerance (HP:0000833)2.06423211
83Papilledema (HP:0001085)2.05669860
84Chronic otitis media (HP:0000389)2.05147403
85Abnormality of the prostate (HP:0008775)2.04752034
86Ketoacidosis (HP:0001993)2.04385266
87Albinism (HP:0001022)2.03581148
88Palpitations (HP:0001962)2.03181584
89Striae distensae (HP:0001065)2.02660090
90Thoracolumbar scoliosis (HP:0002944)2.01771766
91Abnormality of T cells (HP:0002843)2.01007758
92Hepatosplenomegaly (HP:0001433)2.00381951
93Frequent falls (HP:0002359)2.00106805
94Hematochezia (HP:0002573)1.98174187
95Severe short stature (HP:0003510)1.98033655
96Leukocytosis (HP:0001974)1.97584507
97Hypoplasia of the thymus (HP:0000778)1.96339032
98Increased IgE level (HP:0003212)1.95836299
99Gastrointestinal inflammation (HP:0004386)1.95489117
100Obstructive lung disease (HP:0006536)1.94806377
101Chronic obstructive pulmonary disease (HP:0006510)1.94806377
102Vertebral arch anomaly (HP:0008438)1.93822166
103Spontaneous hematomas (HP:0007420)1.93610123
104Polycythemia (HP:0001901)1.93497963
105Thyroiditis (HP:0100646)1.92530858
106Hepatocellular necrosis (HP:0001404)1.91664783
107Hypoglycemic coma (HP:0001325)1.90733535
108Interstitial pulmonary disease (HP:0006530)1.90533260
109Pulmonary fibrosis (HP:0002206)1.90291057
110Arterial thrombosis (HP:0004420)1.90129185
111Mucosal telangiectasiae (HP:0100579)1.88230453
112Recurrent sinusitis (HP:0011108)1.87028880
113Resting tremor (HP:0002322)1.87022321
114Aortic aneurysm (HP:0004942)1.86744566
115Chest pain (HP:0100749)1.85803669
116Abnormality of iron homeostasis (HP:0011031)1.85138116
117Abnormality of transition element cation homeostasis (HP:0011030)1.84792614
118Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.84565139
119Abnormality of B cell number (HP:0010975)1.84321976
120Hemoptysis (HP:0002105)1.82735802
121Dilatation of the ascending aorta (HP:0005111)1.82577847
122Episodic fever (HP:0001954)1.82080244
123Pustule (HP:0200039)1.81046941
124Vasculitis (HP:0002633)1.80455212
125Congenital stationary night blindness (HP:0007642)1.80180728
126Polyneuropathy (HP:0001271)1.79815141
127Nemaline bodies (HP:0003798)1.79080798
128Fatigue (HP:0012378)1.79031425
129Abnormality of T cell physiology (HP:0011840)1.78771746
130Recurrent fungal infections (HP:0002841)1.78577396
131Thoracic kyphosis (HP:0002942)1.77148243
132Increased cerebral lipofuscin (HP:0011813)1.77014985
133Inflammation of the large intestine (HP:0002037)1.76993152
134Insomnia (HP:0100785)1.76914777
135Increased neuronal autofluorescent lipopigment (HP:0002074)1.76455069
136Diminished motivation (HP:0000745)1.76070925
137Increased serum ferritin (HP:0003281)1.75819611
138Hypergammaglobulinemia (HP:0010702)1.74735553
139Xanthomatosis (HP:0000991)1.72498209
140Orthostatic hypotension (HP:0001278)1.71274816
141Cellulitis (HP:0100658)1.70754874
142Spastic diplegia (HP:0001264)1.70609228
143Abnormality of cells of the lymphoid lineage (HP:0012140)1.70417730
144Systemic lupus erythematosus (HP:0002725)1.68128471
145Generalized hyperpigmentation (HP:0007440)1.67606142
146Spinal muscular atrophy (HP:0007269)1.67462815
147Recurrent gram-negative bacterial infections (HP:0005420)1.65480407
148Abnormality of purine metabolism (HP:0004352)1.65126337
149Peritonitis (HP:0002586)1.65107870
150Combined immunodeficiency (HP:0005387)1.64880652
151Lymphopenia (HP:0001888)1.64731133
152Abnormality of the motor neurons (HP:0002450)1.64534451
153Abnormal neuron morphology (HP:0012757)1.64534451
154Orchitis (HP:0100796)1.64418076
155Tetraparesis (HP:0002273)1.64036271
156Death in childhood (HP:0003819)1.63776974
157Sensorimotor neuropathy (HP:0007141)1.63524562
158Abnormality of the lumbar spine (HP:0100712)1.63240194
159Global brain atrophy (HP:0002283)1.62603388
160Colitis (HP:0002583)1.62269180
161Aneurysm (HP:0002617)1.61727085
162Joint swelling (HP:0001386)1.61501497
163Myoglobinuria (HP:0002913)1.60833270
164Abnormal platelet function (HP:0011869)1.60750162
165Impaired platelet aggregation (HP:0003540)1.60750162
166Ketosis (HP:0001946)1.60289246
167IgA deficiency (HP:0002720)1.59384841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.85294539
2EEF2K3.58145915
3MST43.50150581
4ERN13.41549099
5MAP4K12.86117771
6PKN22.78712596
7MAP3K102.60487625
8SCYL22.31596635
9FGFR42.09954835
10TESK12.04340929
11FLT31.98140970
12ZAP701.95029838
13TYK21.93200887
14SIK31.89768432
15GRK61.86176313
16MAP3K131.84650442
17KDR1.83456661
18LRRK21.82100213
19ARAF1.80107352
20JAK31.79453613
21FES1.77379318
22TEC1.72962212
23BMPR21.70978731
24MYLK1.69283751
25MAP3K91.68873418
26TBK11.61903370
27PDK21.60556353
28MAP2K31.59292217
29IKBKB1.52646709
30FGFR31.50560887
31KSR21.49578195
32RIPK41.48775301
33JAK11.42080654
34CAMKK21.41241576
35MAP3K51.39616562
36TESK21.36286526
37* MAPKAPK31.35658706
38LIMK11.34243520
39IRAK41.25247159
40TRIM281.25086372
41GRK11.23337538
42PTK61.21864233
43RIPK11.16804827
44TTN1.16324455
45FER1.16050527
46PASK1.12760480
47DYRK1B1.09371856
48LYN1.08207501
49ERBB31.08140382
50JAK21.06956018
51IRAK31.06508591
52TAOK21.05830390
53RAF11.00970746
54KSR11.00343391
55MAP3K120.99723233
56PIM20.99017900
57PTK2B0.98916606
58RET0.98203017
59MAP3K110.93959435
60SYK0.93697889
61PIK3CG0.91266801
62NLK0.90719736
63PAK40.89945701
64MAPK110.89459486
65KIT0.88364816
66TAOK10.87939203
67CSF1R0.86113343
68BCKDK0.83227131
69WNK30.82251889
70BTK0.82229152
71STK100.81927503
72MARK30.81291737
73PRKCQ0.80320240
74IKBKE0.80180213
75MAP3K10.79702443
76EPHB10.79378130
77IRAK10.77417789
78GRK50.77319484
79ITK0.74702527
80CCNB10.73424140
81RPS6KB20.73043589
82EIF2AK30.72508603
83FRK0.72116926
84PINK10.70675526
85FGR0.70638596
86SIK20.69968235
87DAPK20.69344549
88MAP3K30.69343014
89TNK20.68245334
90RPS6KA40.67773797
91PDK30.67177305
92PDK40.67177305
93NTRK10.66896460
94ADRBK20.66772971
95PDGFRA0.66718728
96PRKD30.65843795
97SIK10.64465964
98HIPK20.63833757
99* DAPK10.62222131
100TIE10.61965835
101CHUK0.61029335
102CAMKK10.60908558
103PRKCH0.60528037
104ABL20.60330583
105EIF2AK10.60209562
106ACVR1B0.59913263
107BMPR1B0.59324428
108STK240.58580839
109PIM10.58420421
110STK160.58340673
111NEK20.58320239
112MATK0.56967445
113NEK10.56598050
114MINK10.56199394
115TGFBR20.55851562
116LMTK20.55570784
117ABL10.55060762
118LCK0.54875239
119TAOK30.54789598
120OBSCN0.53037810
121MST1R0.52164176
122MAP4K20.51449429
123CSK0.51313584
124TLK10.50695739
125TGFBR10.50576439
126BRSK10.50300577
127MAP3K20.50157413
128IGF1R0.50001578
129NEK90.48334797
130PDK10.48305482
131RPS6KA20.48087612
132PRKD10.47595174
133HCK0.46935025
134MAP2K10.44878357
135BLK0.44644429
136PAK30.44381675
137CSNK1G30.44342943
138PRKCI0.43106904
139MAP3K140.43020536
140CDK60.42880903
141DYRK30.42716755
142EGFR0.41578223
143PHKG10.40881749
144PHKG20.40881749
145TXK0.39233856
146PTK20.38938323
147UHMK10.38802974
148MAP2K40.38716794
149TRPM70.37502986
150MAP2K60.37106567
151ADRBK10.35645509
152FYN0.34212174

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.15260927
2Graft-versus-host disease_Homo sapiens_hsa053322.88377409
3Allograft rejection_Homo sapiens_hsa053302.84473127
4Autoimmune thyroid disease_Homo sapiens_hsa053202.71227286
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.56530525
6SNARE interactions in vesicular transport_Homo sapiens_hsa041302.18113801
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.18001465
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.09713820
9Sulfur metabolism_Homo sapiens_hsa009202.09136045
10Asthma_Homo sapiens_hsa053102.04898216
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92558344
12Staphylococcus aureus infection_Homo sapiens_hsa051501.84090294
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.80216074
14Shigellosis_Homo sapiens_hsa051311.68197213
15Antigen processing and presentation_Homo sapiens_hsa046121.67280381
16B cell receptor signaling pathway_Homo sapiens_hsa046621.64889755
17Primary immunodeficiency_Homo sapiens_hsa053401.64504840
18Fatty acid elongation_Homo sapiens_hsa000621.58986067
19Rheumatoid arthritis_Homo sapiens_hsa053231.57731352
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56015419
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55541714
22Osteoclast differentiation_Homo sapiens_hsa043801.55272365
23Leishmaniasis_Homo sapiens_hsa051401.55170543
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54197006
25VEGF signaling pathway_Homo sapiens_hsa043701.51813880
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51096276
27T cell receptor signaling pathway_Homo sapiens_hsa046601.48628033
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.44959512
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.44525898
30Legionellosis_Homo sapiens_hsa051341.44221790
31Carbohydrate digestion and absorption_Homo sapiens_hsa049731.44084892
32Insulin resistance_Homo sapiens_hsa049311.41221861
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.37990989
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37730249
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37471218
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35717003
37Apoptosis_Homo sapiens_hsa042101.34377836
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30760452
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.29619644
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27748537
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24510873
42Lysosome_Homo sapiens_hsa041421.24083282
43Toxoplasmosis_Homo sapiens_hsa051451.22948454
44Chronic myeloid leukemia_Homo sapiens_hsa052201.22947706
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21571700
46Pancreatic cancer_Homo sapiens_hsa052121.21379770
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.19374677
48Prolactin signaling pathway_Homo sapiens_hsa049171.17770562
49Measles_Homo sapiens_hsa051621.14152436
50Selenocompound metabolism_Homo sapiens_hsa004501.13992780
51Acute myeloid leukemia_Homo sapiens_hsa052211.13168382
52Peroxisome_Homo sapiens_hsa041461.09274618
53mTOR signaling pathway_Homo sapiens_hsa041501.08857982
54Chemical carcinogenesis_Homo sapiens_hsa052041.04482760
55Insulin signaling pathway_Homo sapiens_hsa049101.02752555
56N-Glycan biosynthesis_Homo sapiens_hsa005101.01999209
57Caffeine metabolism_Homo sapiens_hsa002321.01055912
58Other glycan degradation_Homo sapiens_hsa005111.00540552
59Thyroid cancer_Homo sapiens_hsa052160.99507452
60Non-small cell lung cancer_Homo sapiens_hsa052230.99275595
61Tuberculosis_Homo sapiens_hsa051520.98203639
62Influenza A_Homo sapiens_hsa051640.98100678
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.98043795
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.97794533
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.96873177
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.96848358
67Pertussis_Homo sapiens_hsa051330.96510586
68Platelet activation_Homo sapiens_hsa046110.95690543
69Fructose and mannose metabolism_Homo sapiens_hsa000510.95551713
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94412314
71Malaria_Homo sapiens_hsa051440.93490741
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92709695
73Glucagon signaling pathway_Homo sapiens_hsa049220.90978808
74Pentose phosphate pathway_Homo sapiens_hsa000300.90095123
75Hepatitis B_Homo sapiens_hsa051610.89726785
76Phagosome_Homo sapiens_hsa041450.88445874
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87938874
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87834698
79Complement and coagulation cascades_Homo sapiens_hsa046100.87107792
80Nitrogen metabolism_Homo sapiens_hsa009100.86456761
81Chemokine signaling pathway_Homo sapiens_hsa040620.85569004
82Carbon metabolism_Homo sapiens_hsa012000.84970683
83Type II diabetes mellitus_Homo sapiens_hsa049300.84135550
84TNF signaling pathway_Homo sapiens_hsa046680.83129641
85Glutathione metabolism_Homo sapiens_hsa004800.82564915
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82416065
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82034759
88Viral carcinogenesis_Homo sapiens_hsa052030.81232685
89Endocytosis_Homo sapiens_hsa041440.80875970
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80545165
91Protein export_Homo sapiens_hsa030600.79357705
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78560668
93Collecting duct acid secretion_Homo sapiens_hsa049660.78294444
94Salmonella infection_Homo sapiens_hsa051320.76822532
95Viral myocarditis_Homo sapiens_hsa054160.75231154
96Hematopoietic cell lineage_Homo sapiens_hsa046400.75107334
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74513960
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74298829
99Glioma_Homo sapiens_hsa052140.72278026
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71307781
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70904343
102Fatty acid degradation_Homo sapiens_hsa000710.70554211
103Biosynthesis of amino acids_Homo sapiens_hsa012300.69518567
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69381329
105HIF-1 signaling pathway_Homo sapiens_hsa040660.68032281
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.67673244
107Small cell lung cancer_Homo sapiens_hsa052220.67383172
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67132331
109Proteoglycans in cancer_Homo sapiens_hsa052050.66160884
110Endometrial cancer_Homo sapiens_hsa052130.65979549
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.65711168
112Colorectal cancer_Homo sapiens_hsa052100.65413613
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.65283131
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65212330
115Epstein-Barr virus infection_Homo sapiens_hsa051690.65023637
116Arginine biosynthesis_Homo sapiens_hsa002200.63525525
117Hepatitis C_Homo sapiens_hsa051600.63444796
118Arachidonic acid metabolism_Homo sapiens_hsa005900.62324415
119HTLV-I infection_Homo sapiens_hsa051660.62166811
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61221383
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60994836
122Bladder cancer_Homo sapiens_hsa052190.59245138
123Herpes simplex infection_Homo sapiens_hsa051680.58843977
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58503321
125Renin-angiotensin system_Homo sapiens_hsa046140.57632481
126AMPK signaling pathway_Homo sapiens_hsa041520.57395237
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57388358
128PPAR signaling pathway_Homo sapiens_hsa033200.57240870
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.56089038
130Type I diabetes mellitus_Homo sapiens_hsa049400.56055090
131Oxidative phosphorylation_Homo sapiens_hsa001900.55372940
132Galactose metabolism_Homo sapiens_hsa000520.54631576
133Thyroid hormone synthesis_Homo sapiens_hsa049180.54504500
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54410664
135Oocyte meiosis_Homo sapiens_hsa041140.53186426
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52957764
137Histidine metabolism_Homo sapiens_hsa003400.51995590
138Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51879777
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.50050266
140Insulin secretion_Homo sapiens_hsa049110.49882906
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48220315
142Glycerolipid metabolism_Homo sapiens_hsa005610.47075702
143RNA polymerase_Homo sapiens_hsa030200.46802020
144Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46259882
145Starch and sucrose metabolism_Homo sapiens_hsa005000.46041099
146Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44874313
147* Regulation of autophagy_Homo sapiens_hsa041400.43957453
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43920011
149Fat digestion and absorption_Homo sapiens_hsa049750.43473401
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41212992
151Tryptophan metabolism_Homo sapiens_hsa003800.41157966
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39781673
153Parkinsons disease_Homo sapiens_hsa050120.37464329

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