BEGAIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)7.40665193
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.66833849
3locomotory exploration behavior (GO:0035641)6.18580215
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.84564783
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.82625978
6vocalization behavior (GO:0071625)5.58525906
7synaptic vesicle exocytosis (GO:0016079)5.45304942
8glutamate secretion (GO:0014047)5.45024761
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.34447305
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.23738463
11regulation of synaptic vesicle exocytosis (GO:2000300)5.22052144
12regulation of glutamate receptor signaling pathway (GO:1900449)5.06201088
13regulation of neuronal synaptic plasticity (GO:0048168)4.83236641
14neurotransmitter secretion (GO:0007269)4.79938758
15regulation of long-term neuronal synaptic plasticity (GO:0048169)4.74038428
16exploration behavior (GO:0035640)4.73035595
17protein localization to synapse (GO:0035418)4.72293687
18proline transport (GO:0015824)4.69187047
19regulation of synaptic vesicle transport (GO:1902803)4.65765708
20layer formation in cerebral cortex (GO:0021819)4.53747783
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.52963101
22regulation of synapse structural plasticity (GO:0051823)4.51612480
23dendritic spine morphogenesis (GO:0060997)4.49234263
24neuron cell-cell adhesion (GO:0007158)4.24818039
25neuronal action potential propagation (GO:0019227)4.22304430
26synaptic transmission, glutamatergic (GO:0035249)4.14978919
27regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.08389786
28gamma-aminobutyric acid transport (GO:0015812)4.06101539
29cerebellar granule cell differentiation (GO:0021707)3.98692816
30neurotransmitter-gated ion channel clustering (GO:0072578)3.92742044
31neurotransmitter transport (GO:0006836)3.91360816
32long-term memory (GO:0007616)3.91190839
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87459240
34central nervous system myelination (GO:0022010)3.85766313
35axon ensheathment in central nervous system (GO:0032291)3.85766313
36neuron-neuron synaptic transmission (GO:0007270)3.84338073
37regulation of synapse maturation (GO:0090128)3.83566637
38glutamate receptor signaling pathway (GO:0007215)3.81554231
39positive regulation of membrane potential (GO:0045838)3.81473681
40cellular potassium ion homeostasis (GO:0030007)3.78973388
41positive regulation of synaptic transmission, GABAergic (GO:0032230)3.78301956
42negative regulation of synaptic transmission, GABAergic (GO:0032229)3.76738024
43sodium ion export (GO:0071436)3.76552158
44neuromuscular process controlling balance (GO:0050885)3.76399799
45regulation of dendritic spine morphogenesis (GO:0061001)3.72740227
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.71966744
47neuromuscular process controlling posture (GO:0050884)3.70063436
48positive regulation of dendritic spine morphogenesis (GO:0061003)3.68484480
49activation of protein kinase A activity (GO:0034199)3.68275361
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.67955178
51regulation of synaptic plasticity (GO:0048167)3.64233854
52auditory behavior (GO:0031223)3.63717908
53regulation of neurotransmitter levels (GO:0001505)3.63022872
54glycine transport (GO:0015816)3.62482570
55potassium ion homeostasis (GO:0055075)3.61246598
56prepulse inhibition (GO:0060134)3.59562123
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.57382190
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.53803183
59regulation of postsynaptic membrane potential (GO:0060078)3.51545842
60regulation of voltage-gated calcium channel activity (GO:1901385)3.51203188
61neuromuscular synaptic transmission (GO:0007274)3.48584134
62positive regulation of synapse maturation (GO:0090129)3.47198581
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46369419
64transmission of nerve impulse (GO:0019226)3.45534122
65positive regulation of neurotransmitter transport (GO:0051590)3.42747174
66neuronal ion channel clustering (GO:0045161)3.39560347
67response to auditory stimulus (GO:0010996)3.39372000
68neuron recognition (GO:0008038)3.38692280
69establishment of mitochondrion localization (GO:0051654)3.38333338
70regulation of neurotransmitter secretion (GO:0046928)3.38164088
71potassium ion import (GO:0010107)3.37950916
72positive regulation of neurotransmitter secretion (GO:0001956)3.36639669
73synaptic vesicle endocytosis (GO:0048488)3.35639318
74gamma-aminobutyric acid signaling pathway (GO:0007214)3.35260594
75regulation of vesicle fusion (GO:0031338)3.31826218
76G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.29154846
77cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.27672329
78dendritic spine organization (GO:0097061)3.22507553
79long-term synaptic potentiation (GO:0060291)3.21970067
80regulation of synaptic transmission, glutamatergic (GO:0051966)3.21545276
81behavioral defense response (GO:0002209)3.20502297
82behavioral fear response (GO:0001662)3.20502297
83cell communication by electrical coupling (GO:0010644)3.19476519
84regulation of neurotransmitter transport (GO:0051588)3.18732970
85cerebellar Purkinje cell differentiation (GO:0021702)3.18580985
86axonal fasciculation (GO:0007413)3.17816253
87positive regulation of dendritic spine development (GO:0060999)3.15356734
88amino acid import (GO:0043090)3.11632510
89dendrite morphogenesis (GO:0048813)3.09842569
90regulation of dendritic spine development (GO:0060998)3.08974468
91membrane hyperpolarization (GO:0060081)3.07242576
92regulation of respiratory gaseous exchange (GO:0043576)3.07190714
93regulation of respiratory system process (GO:0044065)3.07152133
94positive regulation of synaptic transmission (GO:0050806)3.06088823
95neuromuscular process (GO:0050905)3.05397508
96learning (GO:0007612)3.03295081
97postsynaptic membrane organization (GO:0001941)3.02543397
98vesicle transport along microtubule (GO:0047496)3.02221943
99regulation of glutamate secretion (GO:0014048)3.02152593
100regulation of female receptivity (GO:0045924)3.01799888
101cerebellar Purkinje cell layer development (GO:0021680)3.01370661
102behavioral response to nicotine (GO:0035095)3.00151587
103regulation of ARF protein signal transduction (GO:0032012)2.99823301
104regulation of synaptic transmission (GO:0050804)2.99347660
105chemosensory behavior (GO:0007635)2.99342969
106social behavior (GO:0035176)2.99007101
107intraspecies interaction between organisms (GO:0051703)2.99007101
108membrane depolarization (GO:0051899)2.98694216
109phosphorelay signal transduction system (GO:0000160)2.98683681
110synaptic vesicle transport (GO:0048489)2.98387200
111establishment of synaptic vesicle localization (GO:0097480)2.98387200
112L-amino acid import (GO:0043092)2.98019841
113positive regulation of dendrite development (GO:1900006)2.97707304
114fear response (GO:0042596)2.96677283
115regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95222255
116adult walking behavior (GO:0007628)2.94899991
117presynaptic membrane organization (GO:0097090)2.93663777
118membrane depolarization during action potential (GO:0086010)2.93230959
119mating behavior (GO:0007617)2.92229871
120dopamine receptor signaling pathway (GO:0007212)2.92169492
121cell migration in hindbrain (GO:0021535)2.92069337
122cellular sodium ion homeostasis (GO:0006883)2.91498901
123striatum development (GO:0021756)2.89731639
124acidic amino acid transport (GO:0015800)2.89697720
125synaptic transmission (GO:0007268)2.89656663
126negative regulation of amino acid transport (GO:0051956)2.86790571
127establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.85909365

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.96414356
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.20208537
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11838458
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03342091
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99495592
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.91518147
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.87963099
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.87963099
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74117313
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.70750291
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.70009894
12DROSHA_22980978_ChIP-Seq_HELA_Human2.62313144
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57245744
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55449061
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.52426718
16GBX2_23144817_ChIP-Seq_PC3_Human2.52210850
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.52183001
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51863387
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47798951
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.45587532
21* EZH2_27304074_Chip-Seq_ESCs_Mouse2.44584985
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38451928
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38226841
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35507409
25* EZH2_27294783_Chip-Seq_ESCs_Mouse2.30298505
26* RNF2_27304074_Chip-Seq_ESCs_Mouse2.29158827
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12433276
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.06570240
29ERG_21242973_ChIP-ChIP_JURKAT_Human2.04573329
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93104749
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.86520364
32* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.71043057
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68508235
34KDM2B_26808549_Chip-Seq_K562_Human1.64329433
35* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63189311
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.54578473
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53086409
38AR_21572438_ChIP-Seq_LNCaP_Human1.52179277
39P68_20966046_ChIP-Seq_HELA_Human1.50824158
40EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48874618
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.46678349
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44802394
43SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43160825
44* RING1B_27294783_Chip-Seq_NPCs_Mouse1.38020283
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35871675
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34896623
47* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31721058
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30185719
49MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.29057022
50* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27952411
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.27387798
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25395687
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24291359
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22678386
55AR_19668381_ChIP-Seq_PC3_Human1.21563623
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20687757
57* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19253796
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19190371
59SMAD4_21799915_ChIP-Seq_A2780_Human1.18094436
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.17150948
61SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15678130
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15417179
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14619330
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14371648
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12312267
66CREB1_26743006_Chip-Seq_LNCaP_Human1.10667909
67* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08610792
68CTCF_27219007_Chip-Seq_Bcells_Human1.07614750
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06635571
70TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04421020
71TET1_21490601_ChIP-Seq_MESCs_Mouse1.04052506
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02637617
73SMC4_20622854_ChIP-Seq_HELA_Human1.02226486
74* RNF2_27304074_Chip-Seq_NSC_Mouse1.00055287
75NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.98256538
76SMAD3_21741376_ChIP-Seq_HESCs_Human0.97635551
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96854127
78STAT3_23295773_ChIP-Seq_U87_Human0.96400100
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94889524
80* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93713992
81TP53_20018659_ChIP-ChIP_R1E_Mouse0.92731015
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92692558
83YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92316637
84LXR_22292898_ChIP-Seq_THP-1_Human0.91995047
85BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90576406
86CBX2_27304074_Chip-Seq_ESCs_Mouse0.90438235
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90310744
88ZNF274_21170338_ChIP-Seq_K562_Hela0.90082877
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89918467
90SOX3_22085726_ChIP-Seq_NPCs_Mouse0.89803153
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89721536
92SMAD4_21741376_ChIP-Seq_HESCs_Human0.89044972
93AHR_22903824_ChIP-Seq_MCF-7_Human0.88573213
94* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88540232
95* SA1_27219007_Chip-Seq_Bcells_Human0.87601831
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87264304
97IGF1R_20145208_ChIP-Seq_DFB_Human0.86968171
98SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.86886624
99STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86865537
100* OCT4_19829295_ChIP-Seq_ESCs_Human0.86654126
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.86084195
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85011747
103KDM2B_26808549_Chip-Seq_JURKAT_Human0.84440611
104KLF4_19829295_ChIP-Seq_ESCs_Human0.84176534
105SMAD3_21741376_ChIP-Seq_ESCs_Human0.82149904
106RUNX1_26923725_Chip-Seq_HPCs_Mouse0.82035055
107ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81992233
108ESR2_21235772_ChIP-Seq_MCF-7_Human0.81302501
109* TP53_23651856_ChIP-Seq_MEFs_Mouse0.81301404
110DPY_21335234_ChIP-Seq_ESCs_Mouse0.81065105
111CTCF_20526341_ChIP-Seq_ESCs_Human0.80633009
112* AR_25329375_ChIP-Seq_VCAP_Human0.80530093
113SMAD3_21741376_ChIP-Seq_EPCs_Human0.80258181
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80023457
115STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.79274146
116GATA1_26923725_Chip-Seq_HPCs_Mouse0.79152253
117SA1_27219007_Chip-Seq_ERYTHROID_Human0.78756174
118SMAD4_21741376_ChIP-Seq_ESCs_Human0.78675705
119OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.77743096
120KDM2B_26808549_Chip-Seq_DND41_Human0.77324734
121MYC_27129775_Chip-Seq_CORNEA_Mouse0.77248283
122NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.76492617
123ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76268008
124VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75643809
125TOP2B_26459242_ChIP-Seq_MCF-7_Human0.75546201
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.74769417
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.74683916
128TCF4_23295773_ChIP-Seq_U87_Human0.74563053
129E2F1_20622854_ChIP-Seq_HELA_Human0.73853112
130PHF8_20622854_ChIP-Seq_HELA_Human0.73800260
131* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.73293672
132JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.72014216

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.95176132
2MP0003880_abnormal_central_pattern4.79817472
3MP0003635_abnormal_synaptic_transmissio4.25320175
4MP0004270_analgesia3.61754157
5MP0002822_catalepsy3.43392830
6MP0009745_abnormal_behavioral_response3.40541579
7MP0002063_abnormal_learning/memory/cond3.39860724
8MP0002064_seizures3.20645309
9MP0005423_abnormal_somatic_nervous3.19980322
10MP0009046_muscle_twitch2.99496024
11MP0002572_abnormal_emotion/affect_behav2.82651828
12MP0001486_abnormal_startle_reflex2.65200179
13MP0001968_abnormal_touch/_nociception2.56084143
14MP0002272_abnormal_nervous_system2.49317190
15MP0004858_abnormal_nervous_system2.48771655
16MP0002734_abnormal_mechanical_nocicepti2.45275951
17MP0001501_abnormal_sleep_pattern2.35613211
18MP0003122_maternal_imprinting2.26991485
19MP0002733_abnormal_thermal_nociception2.00089916
20MP0002909_abnormal_adrenal_gland1.92164558
21MP0001440_abnormal_grooming_behavior1.91337760
22MP0001970_abnormal_pain_threshold1.90662574
23MP0003787_abnormal_imprinting1.86862019
24MP0004811_abnormal_neuron_physiology1.83301522
25MP0008569_lethality_at_weaning1.76779054
26MP0009780_abnormal_chondrocyte_physiolo1.71081301
27MP0002557_abnormal_social/conspecific_i1.70779050
28MP0002184_abnormal_innervation1.70441649
29MP0000778_abnormal_nervous_system1.70130964
30MP0002736_abnormal_nociception_after1.69793588
31MP0000955_abnormal_spinal_cord1.69563800
32MP0002067_abnormal_sensory_capabilities1.67108851
33MP0003329_amyloid_beta_deposits1.66281536
34MP0004885_abnormal_endolymph1.57941185
35MP0004924_abnormal_behavior1.56878360
36MP0005386_behavior/neurological_phenoty1.56878360
37MP0002735_abnormal_chemical_nociception1.53449478
38MP0008961_abnormal_basal_metabolism1.51192194
39MP0005499_abnormal_olfactory_system1.46512768
40MP0005394_taste/olfaction_phenotype1.46512768
41MP0003283_abnormal_digestive_organ1.45289698
42MP0005646_abnormal_pituitary_gland1.45009197
43MP0002882_abnormal_neuron_morphology1.43084192
44MP0006276_abnormal_autonomic_nervous1.42335717
45MP0002066_abnormal_motor_capabilities/c1.39400063
46MP0004142_abnormal_muscle_tone1.39291396
47MP0003879_abnormal_hair_cell1.35329709
48MP0003633_abnormal_nervous_system1.29275729
49MP0005645_abnormal_hypothalamus_physiol1.27061587
50MP0001905_abnormal_dopamine_level1.23449397
51MP0009379_abnormal_foot_pigmentation1.21462527
52MP0001529_abnormal_vocalization1.21164254
53MP0001984_abnormal_olfaction1.20010570
54MP0008872_abnormal_physiological_respon1.18732232
55MP0002152_abnormal_brain_morphology1.11732248
56MP0003075_altered_response_to1.10853262
57MP0003123_paternal_imprinting1.06991071
58MP0003631_nervous_system_phenotype1.06277741
59MP0001346_abnormal_lacrimal_gland1.04795772
60MP0000579_abnormal_nail_morphology1.04729086
61MP0002638_abnormal_pupillary_reflex1.04663394
62MP0001986_abnormal_taste_sensitivity1.02429932
63MP0001502_abnormal_circadian_rhythm1.01900989
64MP0003121_genomic_imprinting1.00485969
65MP0004130_abnormal_muscle_cell0.98443162
66MP0002653_abnormal_ependyma_morphology0.98305683
67MP0008874_decreased_physiological_sensi0.95599428
68MP0002069_abnormal_eating/drinking_beha0.94706952
69MP0005409_darkened_coat_color0.93822933
70MP0002229_neurodegeneration0.92363889
71MP0005167_abnormal_blood-brain_barrier0.90459168
72MP0003690_abnormal_glial_cell0.89468864
73MP0001177_atelectasis0.89143911
74MP0005623_abnormal_meninges_morphology0.88928250
75MP0004085_abnormal_heartbeat0.85412198
76MP0006292_abnormal_olfactory_placode0.85220884
77MP0000751_myopathy0.85168653
78MP0003634_abnormal_glial_cell0.84871717
79MP0000026_abnormal_inner_ear0.84600669
80MP0005171_absent_coat_pigmentation0.82265862
81MP0000566_synostosis0.81744360
82MP0003137_abnormal_impulse_conducting0.81707141
83MP0003632_abnormal_nervous_system0.81319725
84MP0010030_abnormal_orbit_morphology0.80349235
85MP0000631_abnormal_neuroendocrine_gland0.80167313
86MP0000920_abnormal_myelination0.78855196
87MP0002249_abnormal_larynx_morphology0.78632007
88MP0002752_abnormal_somatic_nervous0.76900799
89MP0008789_abnormal_olfactory_epithelium0.75097525
90MP0005535_abnormal_body_temperature0.74283992
91MP0005551_abnormal_eye_electrophysiolog0.74150215
92MP0002090_abnormal_vision0.69920762
93MP0008877_abnormal_DNA_methylation0.69152878
94MP0000569_abnormal_digit_pigmentation0.67767773
95MP0003861_abnormal_nervous_system0.67501756
96MP0004145_abnormal_muscle_electrophysio0.67251744
97MP0001963_abnormal_hearing_physiology0.66327570
98MP0000049_abnormal_middle_ear0.64560630
99MP0001348_abnormal_lacrimal_gland0.64422571
100MP0003136_yellow_coat_color0.63664106
101MP0003172_abnormal_lysosome_physiology0.63295772
102MP0004043_abnormal_pH_regulation0.63125302
103MP0000013_abnormal_adipose_tissue0.61952307
104MP0010386_abnormal_urinary_bladder0.61761401
105MP0001943_abnormal_respiration0.60772387
106MP0000604_amyloidosis0.59548619
107MP0003878_abnormal_ear_physiology0.57751564
108MP0005377_hearing/vestibular/ear_phenot0.57751564
109MP0010234_abnormal_vibrissa_follicle0.57355788
110MP0003938_abnormal_ear_development0.56260352
111MP0010769_abnormal_survival0.56115088
112MP0002332_abnormal_exercise_endurance0.56087915
113MP0010768_mortality/aging0.52539334
114MP0001188_hyperpigmentation0.52366169
115MP0002082_postnatal_lethality0.51280504
116MP0010770_preweaning_lethality0.51280504
117MP0003956_abnormal_body_size0.50774712
118MP0004742_abnormal_vestibular_system0.47335660
119MP0001485_abnormal_pinna_reflex0.46444044

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.14801310
2Focal motor seizures (HP:0011153)6.56080597
3Focal seizures (HP:0007359)5.49436507
4Visual hallucinations (HP:0002367)5.03773876
5Epileptic encephalopathy (HP:0200134)4.42565986
6Abnormality of the lower motor neuron (HP:0002366)4.34705474
7Febrile seizures (HP:0002373)4.13179432
8Atonic seizures (HP:0010819)3.96831828
9Supranuclear gaze palsy (HP:0000605)3.88909535
10Ankle clonus (HP:0011448)3.76511564
11Generalized tonic-clonic seizures (HP:0002069)3.68735192
12Progressive cerebellar ataxia (HP:0002073)3.59700145
13Absence seizures (HP:0002121)3.58945032
14Action tremor (HP:0002345)3.58422695
15Dialeptic seizures (HP:0011146)3.52884932
16Depression (HP:0000716)3.34634859
17Amblyopia (HP:0000646)3.24689621
18Impaired vibration sensation in the lower limbs (HP:0002166)3.23304018
19Postural instability (HP:0002172)3.16896826
20Poor eye contact (HP:0000817)3.11348641
21Dysdiadochokinesis (HP:0002075)3.06325058
22Papilledema (HP:0001085)3.05857589
23Mutism (HP:0002300)3.04716002
24Urinary bladder sphincter dysfunction (HP:0002839)3.03792705
25Hemiparesis (HP:0001269)2.94290657
26Cerebral hypomyelination (HP:0006808)2.92313447
27Broad-based gait (HP:0002136)2.89005775
28Impaired social interactions (HP:0000735)2.88320956
29Abnormal social behavior (HP:0012433)2.88320956
30Torticollis (HP:0000473)2.85457008
31Dysmetria (HP:0001310)2.85368839
32Hyperventilation (HP:0002883)2.83704197
33Akinesia (HP:0002304)2.83096609
34Anxiety (HP:0000739)2.82271764
35Abnormal eating behavior (HP:0100738)2.82222627
36Annular pancreas (HP:0001734)2.72166632
37Amyotrophic lateral sclerosis (HP:0007354)2.70777559
38Urinary urgency (HP:0000012)2.67800809
39Spastic gait (HP:0002064)2.62151319
40Bradykinesia (HP:0002067)2.60378960
41Sleep apnea (HP:0010535)2.58204931
42Gaze-evoked nystagmus (HP:0000640)2.56615986
43Intention tremor (HP:0002080)2.54810643
44Focal dystonia (HP:0004373)2.53742067
45Genetic anticipation (HP:0003743)2.51270250
46Truncal ataxia (HP:0002078)2.47717834
47Resting tremor (HP:0002322)2.47480312
48Abnormality of the corticospinal tract (HP:0002492)2.46690389
49Hemiplegia (HP:0002301)2.46315727
50Status epilepticus (HP:0002133)2.44959170
51Ventricular fibrillation (HP:0001663)2.43695767
52Generalized hypotonia (HP:0001290)2.41069666
53Insomnia (HP:0100785)2.39459395
54Excessive salivation (HP:0003781)2.38695042
55Drooling (HP:0002307)2.38695042
56Impaired smooth pursuit (HP:0007772)2.36143898
57Rib fusion (HP:0000902)2.35430071
58Neurofibrillary tangles (HP:0002185)2.34985928
59Bilateral microphthalmos (HP:0007633)2.33714161
60Ankyloglossia (HP:0010296)2.32718377
61Lower limb muscle weakness (HP:0007340)2.31927489
62Cerebral inclusion bodies (HP:0100314)2.31102607
63Pointed chin (HP:0000307)2.30655371
64Spinal canal stenosis (HP:0003416)2.29547187
65Craniofacial dystonia (HP:0012179)2.29021460
66Stereotypic behavior (HP:0000733)2.28932861
67Limb dystonia (HP:0002451)2.26756772
68Neoplasm of the heart (HP:0100544)2.25536386
69Impaired vibratory sensation (HP:0002495)2.24614878
70Megalencephaly (HP:0001355)2.23723190
71Abnormality of ocular smooth pursuit (HP:0000617)2.22695073
72Hepatoblastoma (HP:0002884)2.20799114
73Tetraplegia (HP:0002445)2.20260193
74Turricephaly (HP:0000262)2.16587992
75Oligodactyly (hands) (HP:0001180)2.16411665
76Progressive inability to walk (HP:0002505)2.15446708
77Generalized myoclonic seizures (HP:0002123)2.11220077
78Neuronal loss in central nervous system (HP:0002529)2.10736811
79Hypsarrhythmia (HP:0002521)2.09570936
80Clonus (HP:0002169)2.06897968
81Diplopia (HP:0000651)2.06674209
82Abnormality of binocular vision (HP:0011514)2.06674209
83Failure to thrive in infancy (HP:0001531)2.06568582
84Hyperthyroidism (HP:0000836)2.06288823
85Morphological abnormality of the pyramidal tract (HP:0002062)2.04556095
86Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.04445316
87Apathy (HP:0000741)2.04053372
88Oligodactyly (HP:0012165)2.03576021
89Obstructive sleep apnea (HP:0002870)2.00008311
90CNS hypomyelination (HP:0003429)1.99183776
91Scanning speech (HP:0002168)1.99127280
92Lower limb amyotrophy (HP:0007210)1.99044552
93Absent speech (HP:0001344)1.98876991
94Rapidly progressive (HP:0003678)1.97362951
95Abnormal EKG (HP:0003115)1.93176642
96Hyperacusis (HP:0010780)1.92262514
97Inability to walk (HP:0002540)1.91174314
98Horizontal nystagmus (HP:0000666)1.89646977
99Abnormality of the aortic arch (HP:0012303)1.88773572
100Incomplete penetrance (HP:0003829)1.87086069
101Gait imbalance (HP:0002141)1.85899064
102Termporal pattern (HP:0011008)1.85756945
103Insidious onset (HP:0003587)1.85756945
104Polyphagia (HP:0002591)1.85108981
105Dysmetric saccades (HP:0000641)1.82519425
106Achilles tendon contracture (HP:0001771)1.81969889
107Epileptiform EEG discharges (HP:0011182)1.80773174
108Macroorchidism (HP:0000053)1.79913254
109Spastic tetraplegia (HP:0002510)1.79619429
110Elfin facies (HP:0004428)1.79565891
111Rigidity (HP:0002063)1.78967794
112Spastic tetraparesis (HP:0001285)1.77234912
113EEG with generalized epileptiform discharges (HP:0011198)1.75610211
114Hypoplasia of the corpus callosum (HP:0002079)1.74755662
115Delusions (HP:0000746)1.74526535
116Overriding aorta (HP:0002623)1.74433527
117Astrocytoma (HP:0009592)1.74290941
118Abnormality of the astrocytes (HP:0100707)1.74290941
119Bundle branch block (HP:0011710)1.74165643
120Fetal akinesia sequence (HP:0001989)1.72700548
121Lower limb asymmetry (HP:0100559)1.72367582
122Agitation (HP:0000713)1.72355509
123Paraplegia (HP:0010550)1.68085870
124Peripheral hypomyelination (HP:0007182)1.66076187
125Diminished motivation (HP:0000745)1.64704628
126Retinal atrophy (HP:0001105)1.64177292
127Dyskinesia (HP:0100660)1.63120461

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.61947654
2NTRK34.32500211
3MAP3K94.19355541
4MARK12.89579333
5GRK52.66466802
6MAP3K42.57387919
7MINK12.56664884
8PRKD32.49556853
9DAPK22.49032680
10PAK62.46078216
11NTRK12.32281687
12NTRK22.24279464
13KSR22.19390100
14TYRO32.04805480
15MAP2K41.96556222
16CAMKK11.88663083
17MAP2K71.86422080
18STK381.56586624
19CDK51.54283756
20TAOK11.53385318
21KSR11.51960239
22MAP3K121.51037523
23SIK21.41709857
24DAPK11.41155079
25NEK61.37480310
26RIPK41.30855650
27ARAF1.28588225
28UHMK11.26368379
29ALK1.21871236
30LATS21.21157284
31WNK41.20768382
32PRKCG1.16047779
33PRPF4B1.15979783
34PDK21.15394763
35MARK21.13646353
36FES1.11911775
37TNIK1.11564304
38CDK191.11085157
39PLK21.10610419
40MAP3K131.07690797
41BRAF1.03063728
42MAPK131.02842497
43CDK151.01188963
44CDK181.00635820
45PRKCH0.99241243
46CAMK10.98278728
47MAP3K20.96756373
48STK110.93036250
49MAP3K110.92815649
50CDK140.91937242
51GRK60.90360527
52CDK11A0.89738209
53WNK10.88291204
54CDK120.87640603
55PHKG10.84809196
56PHKG20.84809196
57TNK20.84276819
58PIM20.82451531
59CAMK40.81157527
60PAK30.81065083
61RAF10.78727536
62DYRK20.77499698
63PINK10.76698115
64CAMK2A0.74394503
65PNCK0.74177144
66PKN10.71751530
67LIMK10.71170142
68MOS0.70788215
69RET0.70590389
70LMTK20.69613109
71NEK10.67024497
72RIPK10.66902887
73SGK2230.64972560
74SGK4940.64972560
75ADRBK20.64639230
76CSNK1A1L0.64504240
77MAP3K70.63218640
78DYRK1A0.63061069
79TRIB30.63029915
80PDK10.62842090
81CAMK2G0.62116103
82GRK70.58069988
83MAPK150.57735746
84CAMK1D0.56889245
85SGK10.56236137
86MAP3K10.55085362
87BRSK10.54542004
88MAPK100.54132287
89RPS6KA30.53037285
90CAMKK20.52594322
91CDC42BPA0.52346490
92CSNK1G30.52292652
93CSNK1G20.51395610
94RPS6KA20.51165972
95CASK0.50632561
96PDPK10.50613013
97MAPK70.49761720
98SGK30.48397248
99CAMK2B0.48344709
100PRKCZ0.44129620
101PTK2B0.44068410
102DDR20.43237034
103FYN0.42429132
104MAPK80.42277145
105MAPKAPK50.42122900
106PRKD20.41991255
107DYRK1B0.41873881
108MATK0.41522127
109ICK0.40869376
110DAPK30.40753183
111CAMK1G0.38203147
112OXSR10.37721777
113ERBB20.37481916
114ADRBK10.37249862
115SGK20.37237391
116BMX0.36736786
117MAP2K60.36505612
118PRKAA10.35136052
119PRKCA0.34635415
120GRK10.34581753
121MAPK120.34305034
122PDGFRA0.33603991
123IRAK20.33569995
124PRKACA0.33381756
125TRIM280.31671975
126CSNK1E0.31671182
127GSK3B0.31223427
128STK390.31028054
129CAMK2D0.30343644

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.33904799
2Synaptic vesicle cycle_Homo sapiens_hsa047213.31741651
3Olfactory transduction_Homo sapiens_hsa047402.88243140
4GABAergic synapse_Homo sapiens_hsa047272.79535828
5Circadian entrainment_Homo sapiens_hsa047132.59150588
6Glutamatergic synapse_Homo sapiens_hsa047242.57180074
7Long-term potentiation_Homo sapiens_hsa047202.54617018
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.50473859
9Morphine addiction_Homo sapiens_hsa050322.40926402
10Amphetamine addiction_Homo sapiens_hsa050312.40202330
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37661169
12Dopaminergic synapse_Homo sapiens_hsa047282.14830075
13Salivary secretion_Homo sapiens_hsa049702.11028353
14Insulin secretion_Homo sapiens_hsa049111.90633475
15Cholinergic synapse_Homo sapiens_hsa047251.87875475
16Gastric acid secretion_Homo sapiens_hsa049711.86665158
17Cocaine addiction_Homo sapiens_hsa050301.80758068
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77947938
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76036518
20Oxytocin signaling pathway_Homo sapiens_hsa049211.66155518
21Taste transduction_Homo sapiens_hsa047421.61858205
22Renin secretion_Homo sapiens_hsa049241.61034136
23Serotonergic synapse_Homo sapiens_hsa047261.59275954
24Long-term depression_Homo sapiens_hsa047301.59023897
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56278647
26Calcium signaling pathway_Homo sapiens_hsa040201.55617472
27GnRH signaling pathway_Homo sapiens_hsa049121.55574639
28Nitrogen metabolism_Homo sapiens_hsa009101.54392619
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.42074172
30Gap junction_Homo sapiens_hsa045401.37645420
31cAMP signaling pathway_Homo sapiens_hsa040241.31463902
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28848092
33Glioma_Homo sapiens_hsa052141.23718221
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13997901
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12648025
36Estrogen signaling pathway_Homo sapiens_hsa049151.12439101
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11156070
38Type II diabetes mellitus_Homo sapiens_hsa049301.09772774
39Axon guidance_Homo sapiens_hsa043601.08969479
40ErbB signaling pathway_Homo sapiens_hsa040121.07887202
41Phospholipase D signaling pathway_Homo sapiens_hsa040721.07735032
42Melanogenesis_Homo sapiens_hsa049161.04990178
43Collecting duct acid secretion_Homo sapiens_hsa049661.01366952
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99818078
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95495460
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.94353037
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93079727
48Oocyte meiosis_Homo sapiens_hsa041140.91068497
49Dorso-ventral axis formation_Homo sapiens_hsa043200.89290423
50Cardiac muscle contraction_Homo sapiens_hsa042600.85797639
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85438607
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83980876
53Choline metabolism in cancer_Homo sapiens_hsa052310.82446489
54Dilated cardiomyopathy_Homo sapiens_hsa054140.77203442
55mTOR signaling pathway_Homo sapiens_hsa041500.76513489
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.76376647
57MAPK signaling pathway_Homo sapiens_hsa040100.74589175
58VEGF signaling pathway_Homo sapiens_hsa043700.73949642
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72953153
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70716963
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70211599
62Rap1 signaling pathway_Homo sapiens_hsa040150.68952599
63Hedgehog signaling pathway_Homo sapiens_hsa043400.68607271
64Thyroid hormone synthesis_Homo sapiens_hsa049180.67536681
65Phototransduction_Homo sapiens_hsa047440.67149983
66Pancreatic secretion_Homo sapiens_hsa049720.66026429
67Hippo signaling pathway_Homo sapiens_hsa043900.64379763
68Ras signaling pathway_Homo sapiens_hsa040140.64282893
69Vibrio cholerae infection_Homo sapiens_hsa051100.63974466
70Non-small cell lung cancer_Homo sapiens_hsa052230.63866738
71Arginine biosynthesis_Homo sapiens_hsa002200.62071256
72Endocytosis_Homo sapiens_hsa041440.59808853
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59058079
74Arginine and proline metabolism_Homo sapiens_hsa003300.58106039
75Bile secretion_Homo sapiens_hsa049760.57989822
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.57373556
77Inositol phosphate metabolism_Homo sapiens_hsa005620.56477680
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56008446
79Alcoholism_Homo sapiens_hsa050340.55915805
80Sulfur relay system_Homo sapiens_hsa041220.54812594
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53925319
82Type I diabetes mellitus_Homo sapiens_hsa049400.53168899
83Ovarian steroidogenesis_Homo sapiens_hsa049130.51628295
84Endometrial cancer_Homo sapiens_hsa052130.50770019
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50540957
86Alzheimers disease_Homo sapiens_hsa050100.50314285
87Prion diseases_Homo sapiens_hsa050200.49297369
88Regulation of autophagy_Homo sapiens_hsa041400.48749879
89Glucagon signaling pathway_Homo sapiens_hsa049220.48373882
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48355121
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48273235
92Wnt signaling pathway_Homo sapiens_hsa043100.47591843
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47325680
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46401082
95Basal cell carcinoma_Homo sapiens_hsa052170.45398318
96Renal cell carcinoma_Homo sapiens_hsa052110.43564756
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40133547
98Vitamin B6 metabolism_Homo sapiens_hsa007500.39937498
99Insulin signaling pathway_Homo sapiens_hsa049100.39429806
100AMPK signaling pathway_Homo sapiens_hsa041520.38190499
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37164860
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36962460
103Chemokine signaling pathway_Homo sapiens_hsa040620.36165545
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.34453168
105Notch signaling pathway_Homo sapiens_hsa043300.33993061
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33972178
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33817453
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.32449042
109African trypanosomiasis_Homo sapiens_hsa051430.31091205
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29581982
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.23425257
112Ether lipid metabolism_Homo sapiens_hsa005650.20334591
113Biosynthesis of amino acids_Homo sapiens_hsa012300.20008309
114Circadian rhythm_Homo sapiens_hsa047100.19630808

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