BEND2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which has two BEN domains in the C-terminus. These domains are found in proteins which participate in protein and DNA interactions which occur during chromatin restructuring or transcription. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)8.01290906
2thrombin receptor signaling pathway (GO:0070493)7.58839238
3neutrophil activation involved in immune response (GO:0002283)6.10686410
4regulation of platelet aggregation (GO:0090330)5.23879294
5regulation of platelet activation (GO:0010543)5.07068473
6leukocyte migration involved in inflammatory response (GO:0002523)5.01105690
7blood coagulation, intrinsic pathway (GO:0007597)4.83335428
8negative regulation of heart rate (GO:0010459)4.77630281
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.62545463
10negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.57477965
11regulation of integrin-mediated signaling pathway (GO:2001044)4.57188382
12regulation of lipoprotein metabolic process (GO:0050746)4.55597878
13positive regulation of mast cell activation (GO:0033005)4.48420124
14negative regulation of norepinephrine secretion (GO:0010700)4.37875437
15purinergic nucleotide receptor signaling pathway (GO:0035590)4.37512657
16positive regulation of endothelial cell differentiation (GO:0045603)4.36584810
17negative regulation of thymocyte apoptotic process (GO:0070244)4.34592525
18platelet aggregation (GO:0070527)4.24113748
19negative regulation of platelet activation (GO:0010544)4.17067677
20negative regulation of appetite (GO:0032099)4.15361430
21negative regulation of response to food (GO:0032096)4.15361430
22angiogenesis involved in wound healing (GO:0060055)4.09087917
23positive regulation of cAMP-mediated signaling (GO:0043950)4.09002520
24adenosine receptor signaling pathway (GO:0001973)4.05845154
25G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.05353810
26neutrophil activation (GO:0042119)3.94849049
27negative regulation of homotypic cell-cell adhesion (GO:0034111)3.87671163
28negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.75494573
29regulation of memory T cell differentiation (GO:0043380)3.70628119
30fusion of sperm to egg plasma membrane (GO:0007342)3.68607174
31low-density lipoprotein particle remodeling (GO:0034374)3.54372420
32regulation of MHC class II biosynthetic process (GO:0045346)3.46963434
33platelet dense granule organization (GO:0060155)3.43532887
34lipoxygenase pathway (GO:0019372)3.39254058
35granulocyte activation (GO:0036230)3.34553205
36autophagic vacuole fusion (GO:0000046)3.33125532
37termination of G-protein coupled receptor signaling pathway (GO:0038032)3.33033514
38regulation of Golgi to plasma membrane protein transport (GO:0042996)3.32997155
39negative regulation of protein localization to cell surface (GO:2000009)3.32849111
40cellular biogenic amine catabolic process (GO:0042402)3.32332039
41amine catabolic process (GO:0009310)3.32332039
42dopamine transport (GO:0015872)3.31172952
43regulation of endothelial cell differentiation (GO:0045601)3.31105052
44fatty acid elongation (GO:0030497)3.31092331
45regulation of macrophage derived foam cell differentiation (GO:0010743)3.28994306
46regulation of integrin activation (GO:0033623)3.28069400
47purinergic receptor signaling pathway (GO:0035587)3.26971253
48megakaryocyte development (GO:0035855)3.24482856
49regulation of regulatory T cell differentiation (GO:0045589)3.15874906
50termination of signal transduction (GO:0023021)3.14004835
51positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.11264348
52negative regulation of calcium ion transport into cytosol (GO:0010523)3.10329023
53negative regulation of heart contraction (GO:0045822)3.10327721
54regulation of female receptivity (GO:0045924)3.07653571
55regulation of homotypic cell-cell adhesion (GO:0034110)3.06666369
56positive regulation of macrophage differentiation (GO:0045651)3.06349517
57negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.05785334
58negative regulation of T-helper cell differentiation (GO:0045623)3.05785334
59regulation of norepinephrine secretion (GO:0014061)3.03753067
60phosphatidylinositol acyl-chain remodeling (GO:0036149)3.02047359
61regulation of mast cell activation (GO:0033003)2.99173750
62high-density lipoprotein particle remodeling (GO:0034375)2.99047041
63platelet degranulation (GO:0002576)2.97161167
64polyamine biosynthetic process (GO:0006596)2.96114641
65negative regulation of T cell apoptotic process (GO:0070233)2.94957729
66homotypic cell-cell adhesion (GO:0034109)2.94744008
67platelet activation (GO:0030168)2.93813567
68organelle membrane fusion (GO:0090174)2.90164272
69platelet formation (GO:0030220)2.88643699
70positive regulation of hemostasis (GO:1900048)2.88141339
71positive regulation of blood coagulation (GO:0030194)2.88141339
72reverse cholesterol transport (GO:0043691)2.88001482
73positive regulation of Rho protein signal transduction (GO:0035025)2.84238396
74pyrimidine nucleoside catabolic process (GO:0046135)2.84059628
75positive regulation of protein homodimerization activity (GO:0090073)2.81748348
76positive regulation of systemic arterial blood pressure (GO:0003084)2.80988986
77negative regulation of catecholamine secretion (GO:0033604)2.80470477
78adenosine metabolic process (GO:0046085)2.77402984
79regulation of response to food (GO:0032095)2.76836397
80leukocyte degranulation (GO:0043299)2.75985895
81negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.74996803
82microtubule depolymerization (GO:0007019)2.74841144
83plasma membrane fusion (GO:0045026)2.74270603
84monoamine transport (GO:0015844)2.72879333
85glycerophospholipid catabolic process (GO:0046475)2.72573715
86cellular biogenic amine biosynthetic process (GO:0042401)2.70644341
87mitochondrial calcium ion transport (GO:0006851)2.67987204
88negative regulation of neural precursor cell proliferation (GO:2000178)2.65924332
89positive regulation of granulocyte differentiation (GO:0030854)2.64941360
90negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.64817785
91phospholipid homeostasis (GO:0055091)2.63718121
92positive regulation of synaptic transmission, GABAergic (GO:0032230)2.63010715
93superoxide anion generation (GO:0042554)2.61302866
94long-chain fatty acid biosynthetic process (GO:0042759)2.60211836
95positive regulation of B cell mediated immunity (GO:0002714)2.58165985
96positive regulation of immunoglobulin mediated immune response (GO:0002891)2.58165985
97regulation of cilium movement (GO:0003352)2.58129138
98negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.57793865
99positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.56206799
100positive regulation of response to tumor cell (GO:0002836)2.55698955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.40306006
2LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.33732311
3EZH2_22144423_ChIP-Seq_EOC_Human3.06748601
4GBX2_23144817_ChIP-Seq_PC3_Human3.02090968
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64000797
6SCL_19346495_ChIP-Seq_HPC-7_Human2.56058698
7VDR_22108803_ChIP-Seq_LS180_Human2.51575757
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.44937746
9GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.20875173
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17895095
11TAF15_26573619_Chip-Seq_HEK293_Human2.13970882
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.03558894
13LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.97560396
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97141256
15IRF8_21731497_ChIP-ChIP_J774_Mouse1.94454281
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89766197
17HTT_18923047_ChIP-ChIP_STHdh_Human1.89724391
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84053610
19IGF1R_20145208_ChIP-Seq_DFB_Human1.80097075
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79506146
21GATA1_19941826_ChIP-Seq_K562_Human1.75542933
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72685446
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72355766
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69969305
25IRF1_19129219_ChIP-ChIP_H3396_Human1.68771309
26EWS_26573619_Chip-Seq_HEK293_Human1.66513911
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.62443984
28GATA2_19941826_ChIP-Seq_K562_Human1.60917417
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55998551
30ER_23166858_ChIP-Seq_MCF-7_Human1.51330911
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51283951
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50320446
33P300_19829295_ChIP-Seq_ESCs_Human1.49735475
34GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.46812115
35BCAT_22108803_ChIP-Seq_LS180_Human1.46727287
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46070977
37ELK4_26923725_Chip-Seq_MESODERM_Mouse1.45850072
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45617641
39GATA1_19941827_ChIP-Seq_MEL_Mouse1.42336189
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.42205508
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39858316
42GATA1_22025678_ChIP-Seq_K562_Human1.37311584
43ZNF274_21170338_ChIP-Seq_K562_Hela1.37020073
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36703343
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.36590855
46AR_25329375_ChIP-Seq_VCAP_Human1.35240904
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34968782
48* SMAD4_21799915_ChIP-Seq_A2780_Human1.32185546
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29849418
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.29375527
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26813016
52* NANOG_19829295_ChIP-Seq_ESCs_Human1.26608487
53* SOX2_19829295_ChIP-Seq_ESCs_Human1.26608487
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25105239
55SPI1_23127762_ChIP-Seq_K562_Human1.24281671
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.24114066
57STAT3_23295773_ChIP-Seq_U87_Human1.23249549
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.22944300
59TCF4_23295773_ChIP-Seq_U87_Human1.21132446
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20375012
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19827469
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19387464
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19302220
64P53_22387025_ChIP-Seq_ESCs_Mouse1.17072000
65RUNX_20019798_ChIP-Seq_JUKART_Human1.16249507
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16017819
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13781345
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.13781345
69AR_20517297_ChIP-Seq_VCAP_Human1.13463352
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12529481
71GATA3_26560356_Chip-Seq_TH2_Human1.12224129
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11264271
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.11079283
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10350383
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10165458
76TP53_22573176_ChIP-Seq_HFKS_Human1.09724291
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.09669465
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.07814097
79OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06385646
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05677912
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05677912
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05591285
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05591285
84SALL4_22934838_ChIP-ChIP_CD34+_Human1.04691585
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04617186
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04065955
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01876055
88OCT1_27270436_Chip-Seq_PROSTATE_Human1.00638567
89FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00383503
90RNF2_27304074_Chip-Seq_NSC_Mouse0.99394247
91CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99360311
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.98968511
93GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98050372
94SMRT_27268052_Chip-Seq_Bcells_Human0.97740753
95NANOG_20526341_ChIP-Seq_ESCs_Human0.97599356
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97497749
97E2F1_18555785_Chip-Seq_ESCs_Mouse0.97083380
98CDX2_22108803_ChIP-Seq_LS180_Human0.96555996
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.96397627
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.96079279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology8.25473521
2MP0008004_abnormal_stomach_pH4.50459464
3MP0003724_increased_susceptibility_to3.69669606
4MP0000465_gastrointestinal_hemorrhage2.87761902
5MP0002736_abnormal_nociception_after2.54791955
6MP0004510_myositis2.51016094
7MP0008872_abnormal_physiological_respon2.32822117
8MP0000230_abnormal_systemic_arterial2.20547601
9MP0001835_abnormal_antigen_presentation2.15539583
10MP0005084_abnormal_gallbladder_morpholo2.15240153
11MP0005083_abnormal_biliary_tract2.12738177
12MP0004084_abnormal_cardiac_muscle2.12386589
13MP0001968_abnormal_touch/_nociception2.10429492
14MP0005646_abnormal_pituitary_gland2.07626874
15MP0008775_abnormal_heart_ventricle2.05765626
16MP0005671_abnormal_response_to2.02971772
17MP0005167_abnormal_blood-brain_barrier2.00226008
18MP0008877_abnormal_DNA_methylation1.77696519
19MP0000343_altered_response_to1.77696085
20MP0003638_abnormal_response/metabolism_1.74561472
21MP0005410_abnormal_fertilization1.67403541
22MP0004130_abnormal_muscle_cell1.63189254
23MP0002148_abnormal_hypersensitivity_rea1.58881883
24MP0005174_abnormal_tail_pigmentation1.56917856
25MP0000015_abnormal_ear_pigmentation1.52248042
26MP0002733_abnormal_thermal_nociception1.52240714
27MP0006276_abnormal_autonomic_nervous1.50721078
28MP0010329_abnormal_lipoprotein_level1.45824945
29MP0004142_abnormal_muscle_tone1.40229565
30MP0004036_abnormal_muscle_relaxation1.39440583
31MP0003879_abnormal_hair_cell1.36989979
32MP0005000_abnormal_immune_tolerance1.34897351
33MP0009764_decreased_sensitivity_to1.31398976
34MP0010155_abnormal_intestine_physiology1.31222903
35MP0005551_abnormal_eye_electrophysiolog1.30411350
36MP0003011_delayed_dark_adaptation1.29012044
37MP0001663_abnormal_digestive_system1.26974519
38MP0003136_yellow_coat_color1.24178534
39MP0003303_peritoneal_inflammation1.23828767
40MP0009780_abnormal_chondrocyte_physiolo1.22587715
41MP0001970_abnormal_pain_threshold1.18469215
42MP0003195_calcinosis1.17386305
43MP0001851_eye_inflammation1.16764145
44MP0001879_abnormal_lymphatic_vessel1.16581952
45MP0001800_abnormal_humoral_immune1.15736133
46MP0002723_abnormal_immune_serum1.15588412
47MP0002102_abnormal_ear_morphology1.14509875
48MP0002398_abnormal_bone_marrow1.13094459
49MP0004215_abnormal_myocardial_fiber1.10084794
50MP0008875_abnormal_xenobiotic_pharmacok1.09586972
51MP0002876_abnormal_thyroid_physiology1.07568001
52MP0000569_abnormal_digit_pigmentation1.06700229
53MP0000249_abnormal_blood_vessel1.05637700
54MP0003828_pulmonary_edema1.01078226
55MP0004484_altered_response_of0.99625193
56MP0002452_abnormal_antigen_presenting0.99562080
57MP0001664_abnormal_digestion0.98493529
58MP0001765_abnormal_ion_homeostasis0.98409849
59MP0004147_increased_porphyrin_level0.94671822
60MP0000689_abnormal_spleen_morphology0.94456202
61MP0005645_abnormal_hypothalamus_physiol0.94047831
62MP0005387_immune_system_phenotype0.93957759
63MP0001790_abnormal_immune_system0.93957759
64MP0003866_abnormal_defecation0.92313782
65MP0009763_increased_sensitivity_to0.91873419
66MP0009642_abnormal_blood_homeostasis0.90342650
67MP0001533_abnormal_skeleton_physiology0.89358659
68MP0005397_hematopoietic_system_phenotyp0.89111398
69MP0001545_abnormal_hematopoietic_system0.89111398
70MP0003787_abnormal_imprinting0.88509652
71MP0002735_abnormal_chemical_nociception0.87667433
72MP0006054_spinal_hemorrhage0.86851224
73MP0005365_abnormal_bile_salt0.85242415
74MP0002420_abnormal_adaptive_immunity0.84814690
75MP0002132_abnormal_respiratory_system0.84473999
76MP0000685_abnormal_immune_system0.83741098
77MP0001819_abnormal_immune_cell0.83228955
78MP0000383_abnormal_hair_follicle0.82641671
79MP0000372_irregular_coat_pigmentation0.82607530
80MP0002837_dystrophic_cardiac_calcinosis0.81974798
81MP0001845_abnormal_inflammatory_respons0.81036293
82MP0001756_abnormal_urination0.80780861
83MP0003718_maternal_effect0.79721091
84MP0002429_abnormal_blood_cell0.79156745
85MP0005448_abnormal_energy_balance0.77635280
86MP0009765_abnormal_xenobiotic_induced0.77468671
87MP0005381_digestive/alimentary_phenotyp0.77117408
88MP0003436_decreased_susceptibility_to0.74879772
89MP0010386_abnormal_urinary_bladder0.74849631
90MP0004085_abnormal_heartbeat0.74002311
91MP0004947_skin_inflammation0.73593990
92MP0000716_abnormal_immune_system0.71895717
93MP0005535_abnormal_body_temperature0.70404110
94MP0003566_abnormal_cell_adhesion0.70162449
95MP0005085_abnormal_gallbladder_physiolo0.69901748
96MP0003656_abnormal_erythrocyte_physiolo0.69683243
97MP0006036_abnormal_mitochondrial_physio0.69087539
98MP0002118_abnormal_lipid_homeostasis0.68927571
99MP0002693_abnormal_pancreas_physiology0.68871991
100MP0009046_muscle_twitch0.66806012

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.96923374
2Menorrhagia (HP:0000132)8.91848469
3Increased mean platelet volume (HP:0011877)8.76735937
4Petechiae (HP:0000967)8.67938162
5Abnormal platelet volume (HP:0011876)8.19067182
6Purpura (HP:0000979)7.38248420
7Epistaxis (HP:0000421)6.47946156
8Gingival bleeding (HP:0000225)5.94632137
9Hyperlipoproteinemia (HP:0010980)5.05618043
10Abnormal platelet function (HP:0011869)4.79207874
11Impaired platelet aggregation (HP:0003540)4.79207874
12Poikilocytosis (HP:0004447)3.82793011
13Spontaneous hematomas (HP:0007420)3.66059676
14Dyschromatopsia (HP:0007641)3.53819959
15Acanthocytosis (HP:0001927)3.46249048
16Decreased central vision (HP:0007663)3.32345500
17Abnormal pupillary function (HP:0007686)3.13029871
18Stomatitis (HP:0010280)3.10569319
19Bruising susceptibility (HP:0000978)2.88682849
20Conjunctival telangiectasia (HP:0000524)2.81679743
21Thyroid-stimulating hormone excess (HP:0002925)2.77914500
22Abnormality of the heme biosynthetic pathway (HP:0010472)2.75586120
233-Methylglutaconic aciduria (HP:0003535)2.72535778
24Abnormality of the common coagulation pathway (HP:0010990)2.66366229
25Increased density of long bones (HP:0006392)2.65810935
26Abnormality of the vasculature of the conjunctiva (HP:0008054)2.46867832
27Abnormality of lateral ventricle (HP:0030047)2.43123110
28Paralysis (HP:0003470)2.43091647
29Congenital stationary night blindness (HP:0007642)2.42096523
30Tinnitus (HP:0000360)2.31263839
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22947931
32Abnormality of alanine metabolism (HP:0010916)2.22947931
33Hyperalaninemia (HP:0003348)2.22947931
34Joint swelling (HP:0001386)2.19350746
35Abnormal auditory evoked potentials (HP:0006958)2.14631459
36Polyphagia (HP:0002591)2.13643078
37Abnormality of the renal cortex (HP:0011035)2.13449480
38Abnormality of transition element cation homeostasis (HP:0011030)2.11143277
39Tongue fasciculations (HP:0001308)2.10880622
40Pancreatic cysts (HP:0001737)2.09859900
41Renal cortical cysts (HP:0000803)2.07873494
42Xanthomatosis (HP:0000991)2.05850356
43Abolished electroretinogram (ERG) (HP:0000550)2.05624233
44Abnormal ciliary motility (HP:0012262)2.02805292
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.00316627
46Absent/shortened dynein arms (HP:0200106)2.00316627
47Abnormality of iron homeostasis (HP:0011031)1.99747775
48Spontaneous abortion (HP:0005268)1.99499673
49Generalized aminoaciduria (HP:0002909)1.99492360
50Encephalitis (HP:0002383)1.98493901
51Upper limb muscle weakness (HP:0003484)1.95603281
52Joint hemorrhage (HP:0005261)1.93725399
53Aplasia/Hypoplasia of the fovea (HP:0008060)1.93505245
54Hypoplasia of the fovea (HP:0007750)1.93505245
55Abnormal respiratory epithelium morphology (HP:0012253)1.92581553
56Abnormal respiratory motile cilium morphology (HP:0005938)1.92581553
57Abnormality of midbrain morphology (HP:0002418)1.90697130
58Molar tooth sign on MRI (HP:0002419)1.90697130
59Hypomagnesemia (HP:0002917)1.90547022
60Attenuation of retinal blood vessels (HP:0007843)1.89885725
61Increased IgM level (HP:0003496)1.88229235
62Muscle fibrillation (HP:0010546)1.85404222
63Congenital sensorineural hearing impairment (HP:0008527)1.80673009
64Pancreatic fibrosis (HP:0100732)1.78731141
65Episodic fever (HP:0001954)1.78139836
66Lissencephaly (HP:0001339)1.74936017
67True hermaphroditism (HP:0010459)1.72282229
68Abnormal drinking behavior (HP:0030082)1.71652512
69Polydipsia (HP:0001959)1.71652512
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71127532
71Arterial thrombosis (HP:0004420)1.70803756
72Febrile seizures (HP:0002373)1.70746480
73Hyperthyroidism (HP:0000836)1.68309842
74Arthropathy (HP:0003040)1.68284763
75Agitation (HP:0000713)1.67736279
76Ventricular fibrillation (HP:0001663)1.66938741
77Absent rod-and cone-mediated responses on ERG (HP:0007688)1.66155362
78Hypophosphatemic rickets (HP:0004912)1.65180485
79Abnormality of the fovea (HP:0000493)1.65151201
80Clumsiness (HP:0002312)1.64316601
81Abnormal rod and cone electroretinograms (HP:0008323)1.63957823
82Autoimmune hemolytic anemia (HP:0001890)1.61344959
83Abnormality of the prostate (HP:0008775)1.61139942
84Nausea (HP:0002018)1.61058841
85Hypoproteinemia (HP:0003075)1.60804551
86Elevated erythrocyte sedimentation rate (HP:0003565)1.60633272
87Hepatosplenomegaly (HP:0001433)1.60327116
88Abnormal spermatogenesis (HP:0008669)1.59042532
89Optic nerve hypoplasia (HP:0000609)1.58563019
90IgG deficiency (HP:0004315)1.57917045
91Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.57868469
92Exertional dyspnea (HP:0002875)1.56176628
93Abnormal respiratory motile cilium physiology (HP:0012261)1.55980879
94Abnormality of magnesium homeostasis (HP:0004921)1.52942976
95Renal Fanconi syndrome (HP:0001994)1.51448122
96Biliary tract neoplasm (HP:0100574)1.50704806
97Central scotoma (HP:0000603)1.50283356
98Congenital, generalized hypertrichosis (HP:0004540)1.49493019
99Leukocytosis (HP:0001974)1.47544179
100Hyperventilation (HP:0002883)1.46744699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.62920088
2RIPK43.92644197
3TAOK32.95745053
4BMX2.90942967
5FRK2.89077426
6ADRBK22.88103336
7TEC2.72407672
8MYLK2.55721254
9PTK2B2.42034027
10EIF2AK12.38568095
11TXK2.37939208
12BTK2.21438230
13SYK1.99078940
14PIK3CG1.96509486
15BMPR1B1.92756001
16ACVR1B1.91010688
17CSF1R1.81398675
18GRK51.79614228
19STK31.71520531
20PNCK1.68750120
21BMPR21.66334416
22NUAK11.49952287
23TNIK1.45931379
24GRK11.45404568
25ZAK1.44625730
26TLK11.42556413
27MAP4K21.41374708
28PLK21.33105890
29ADRBK11.29921009
30GRK61.25412097
31DAPK21.20245480
32ZAP701.19613759
33TRIM281.17545363
34MAPKAPK31.15955821
35FGR1.14938623
36IKBKB1.13639380
37HCK1.12379580
38MAPK131.12332293
39ILK1.08597731
40FES1.07538383
41IRAK11.07264845
42INSRR1.02497732
43ITK0.98311442
44PAK30.98205491
45LYN0.96668596
46TNK20.95086802
47WNK40.85194197
48PINK10.81758933
49STK240.78067297
50WNK30.75356472
51CAMKK20.73149684
52FER0.72869242
53EPHA30.72711588
54ERBB20.70695209
55BRSK20.68533261
56PAK10.66482399
57MARK30.65210494
58NLK0.65151346
59LMTK20.61812723
60PDK10.61128821
61DYRK20.60610428
62MAP2K10.60039025
63MATK0.59343232
64PHKG20.58347897
65PHKG10.58347897
66PRKCQ0.57322608
67PRKCE0.57268452
68STK390.56916032
69PKN10.56034329
70SIK30.55965897
71LCK0.53966765
72OXSR10.53729587
73DAPK30.53140212
74PRKCG0.52674658
75PRKG10.48950801
76MAP3K50.46901806
77PRKACG0.46582782
78BLK0.45766493
79PRKD10.44290112
80MAP4K10.41979078
81PIM20.41971529
82PRKCA0.39077891
83CAMK2A0.37218120
84STK40.37014190
85IGF1R0.36964724
86DAPK10.34468638
87FLT30.33899472
88CSK0.33390548
89MUSK0.32799077
90SGK20.32771610
91NTRK30.32234735
92VRK10.31895641
93PRKCB0.31647217
94PRKACA0.30058025
95JAK30.29589428
96CAMK10.28879720
97RET0.28373910
98PLK30.28046510
99PDPK10.27734753
100MINK10.27643333

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046114.66589242
2Nitrogen metabolism_Homo sapiens_hsa009103.27828492
3SNARE interactions in vesicular transport_Homo sapiens_hsa041302.68402731
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.62069578
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.58377267
6Arachidonic acid metabolism_Homo sapiens_hsa005902.47497935
7Linoleic acid metabolism_Homo sapiens_hsa005912.42209486
8Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.27709507
9Hematopoietic cell lineage_Homo sapiens_hsa046402.25683352
10Phototransduction_Homo sapiens_hsa047442.02511763
11Serotonergic synapse_Homo sapiens_hsa047261.94752826
12Olfactory transduction_Homo sapiens_hsa047401.77258185
13Vascular smooth muscle contraction_Homo sapiens_hsa042701.72162794
14Collecting duct acid secretion_Homo sapiens_hsa049661.63937237
15Glycerolipid metabolism_Homo sapiens_hsa005611.51416082
16Chemokine signaling pathway_Homo sapiens_hsa040621.48781817
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47434983
18ECM-receptor interaction_Homo sapiens_hsa045121.45454269
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42397698
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39916975
21Primary immunodeficiency_Homo sapiens_hsa053401.38578915
22Morphine addiction_Homo sapiens_hsa050321.37593294
23Circadian entrainment_Homo sapiens_hsa047131.27063887
24Pancreatic secretion_Homo sapiens_hsa049721.20039103
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17603412
26Sulfur metabolism_Homo sapiens_hsa009201.16812046
27Long-term depression_Homo sapiens_hsa047301.16329469
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16100178
29Gap junction_Homo sapiens_hsa045401.15236702
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12990888
31Fatty acid elongation_Homo sapiens_hsa000621.10304369
32Caffeine metabolism_Homo sapiens_hsa002321.08406804
33Ether lipid metabolism_Homo sapiens_hsa005651.07187967
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04755498
35Systemic lupus erythematosus_Homo sapiens_hsa053221.03843405
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.03204478
37Alcoholism_Homo sapiens_hsa050341.01467601
38ABC transporters_Homo sapiens_hsa020100.94850953
39Regulation of autophagy_Homo sapiens_hsa041400.92942803
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91866519
41GABAergic synapse_Homo sapiens_hsa047270.90661537
42T cell receptor signaling pathway_Homo sapiens_hsa046600.88288541
43Fat digestion and absorption_Homo sapiens_hsa049750.88199930
44Chemical carcinogenesis_Homo sapiens_hsa052040.86089834
45Glycerophospholipid metabolism_Homo sapiens_hsa005640.85067010
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.85030614
47Graft-versus-host disease_Homo sapiens_hsa053320.82517415
48Calcium signaling pathway_Homo sapiens_hsa040200.80840627
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78183978
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78059415
51Asthma_Homo sapiens_hsa053100.76997068
52beta-Alanine metabolism_Homo sapiens_hsa004100.74504711
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.73254714
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71916989
55Glutamatergic synapse_Homo sapiens_hsa047240.68401744
56Malaria_Homo sapiens_hsa051440.68194542
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67776679
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67374760
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67164729
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66980704
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66949174
62B cell receptor signaling pathway_Homo sapiens_hsa046620.65411816
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64470978
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.64157582
65Endocytosis_Homo sapiens_hsa041440.63662990
66Butanoate metabolism_Homo sapiens_hsa006500.62340506
67Staphylococcus aureus infection_Homo sapiens_hsa051500.61971680
68Ovarian steroidogenesis_Homo sapiens_hsa049130.61607549
69Type I diabetes mellitus_Homo sapiens_hsa049400.61506097
70Allograft rejection_Homo sapiens_hsa053300.61133142
71Phagosome_Homo sapiens_hsa041450.57987867
72Autoimmune thyroid disease_Homo sapiens_hsa053200.57531996
73Choline metabolism in cancer_Homo sapiens_hsa052310.57097667
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56933375
75Retinol metabolism_Homo sapiens_hsa008300.56670722
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56417892
77Salivary secretion_Homo sapiens_hsa049700.55955329
78Ras signaling pathway_Homo sapiens_hsa040140.55952703
79Cholinergic synapse_Homo sapiens_hsa047250.55435091
80Rheumatoid arthritis_Homo sapiens_hsa053230.54608922
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.54553453
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50632751
83Glutathione metabolism_Homo sapiens_hsa004800.50533184
84Gastric acid secretion_Homo sapiens_hsa049710.50417492
85Shigellosis_Homo sapiens_hsa051310.50262429
86Renin secretion_Homo sapiens_hsa049240.48757279
87Starch and sucrose metabolism_Homo sapiens_hsa005000.46246864
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.45103738
89Rap1 signaling pathway_Homo sapiens_hsa040150.44946165
90Tryptophan metabolism_Homo sapiens_hsa003800.43007537
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41008893
92Oxytocin signaling pathway_Homo sapiens_hsa049210.40740156
93Sphingolipid metabolism_Homo sapiens_hsa006000.40670092
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39264607
95Purine metabolism_Homo sapiens_hsa002300.38216558
96Taste transduction_Homo sapiens_hsa047420.37230843
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36460347
98Renin-angiotensin system_Homo sapiens_hsa046140.35687840
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.34520873
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33963067

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