BEND3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.20289490
2nuclear pore complex assembly (GO:0051292)5.12935438
3pre-miRNA processing (GO:0031054)4.84191198
4nucleobase biosynthetic process (GO:0046112)4.68991212
5protein localization to kinetochore (GO:0034501)4.53987381
6chromatin remodeling at centromere (GO:0031055)4.53623994
7purine nucleobase biosynthetic process (GO:0009113)4.47209888
8DNA unwinding involved in DNA replication (GO:0006268)4.35114146
9mitotic nuclear envelope disassembly (GO:0007077)4.33868142
10folic acid-containing compound biosynthetic process (GO:0009396)4.28851901
11regulation of posttranscriptional gene silencing (GO:0060147)4.27274264
12regulation of gene silencing by miRNA (GO:0060964)4.27274264
13regulation of gene silencing by RNA (GO:0060966)4.27274264
14CENP-A containing nucleosome assembly (GO:0034080)4.24051900
15ribosome assembly (GO:0042255)4.19432346
16mitotic metaphase plate congression (GO:0007080)4.14585940
17establishment of integrated proviral latency (GO:0075713)4.05738685
18DNA double-strand break processing (GO:0000729)4.05359367
19membrane disassembly (GO:0030397)4.02518214
20nuclear envelope disassembly (GO:0051081)4.02518214
21negative regulation of DNA-dependent DNA replication (GO:2000104)4.00794932
22pore complex assembly (GO:0046931)3.92138207
23DNA replication-dependent nucleosome assembly (GO:0006335)3.89954094
24DNA replication-dependent nucleosome organization (GO:0034723)3.89954094
25ribosome biogenesis (GO:0042254)3.89333333
26histone exchange (GO:0043486)3.89306751
27DNA replication initiation (GO:0006270)3.87410862
28DNA replication checkpoint (GO:0000076)3.85158953
29IMP biosynthetic process (GO:0006188)3.82080642
30formation of translation preinitiation complex (GO:0001731)3.78329913
31regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.76928450
32negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.71465481
33negative regulation of translation, ncRNA-mediated (GO:0040033)3.71465481
34regulation of translation, ncRNA-mediated (GO:0045974)3.71465481
35protein localization to chromosome, centromeric region (GO:0071459)3.71452704
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.71317560
37regulation of spindle organization (GO:0090224)3.67831974
38protein complex localization (GO:0031503)3.66834609
39L-serine metabolic process (GO:0006563)3.65241415
40regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.63132368
41regulation of mitotic spindle checkpoint (GO:1903504)3.63132368
42paraxial mesoderm development (GO:0048339)3.62763269
43regulation of RNA export from nucleus (GO:0046831)3.55939266
44DNA strand elongation involved in DNA replication (GO:0006271)3.53928811
45mitotic sister chromatid segregation (GO:0000070)3.51627138
46positive regulation of chromosome segregation (GO:0051984)3.49133041
47metaphase plate congression (GO:0051310)3.48853179
48heterochromatin organization (GO:0070828)3.48600419
49dosage compensation (GO:0007549)3.43274274
50negative regulation of histone methylation (GO:0031061)3.37631754
51DNA strand elongation (GO:0022616)3.34986882
52replication fork processing (GO:0031297)3.34928857
53DNA duplex unwinding (GO:0032508)3.33696333
54sister chromatid segregation (GO:0000819)3.32914786
55negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.32864535
56DNA geometric change (GO:0032392)3.32563017
57histone H2A monoubiquitination (GO:0035518)3.30297629
58folic acid metabolic process (GO:0046655)3.29163747
59negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.29110744
60nuclear envelope organization (GO:0006998)3.28595224
61non-recombinational repair (GO:0000726)3.27775449
62double-strand break repair via nonhomologous end joining (GO:0006303)3.27775449
63mitotic sister chromatid cohesion (GO:0007064)3.26894277
64negative regulation of DNA recombination (GO:0045910)3.24498664
65maturation of SSU-rRNA (GO:0030490)3.19376028
66DNA damage response, detection of DNA damage (GO:0042769)3.18139911
67cellular protein complex localization (GO:0034629)3.17508414
68IMP metabolic process (GO:0046040)3.16960675
69regulation of mitotic spindle organization (GO:0060236)3.16273223
70maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12467622
71peptidyl-arginine omega-N-methylation (GO:0035247)3.11872676
72regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.11487512
73ribonucleoprotein complex biogenesis (GO:0022613)3.09918085
74mitotic chromosome condensation (GO:0007076)3.08684148
75ATP-dependent chromatin remodeling (GO:0043044)3.06872486
76DNA strand renaturation (GO:0000733)3.06259576
77mitotic recombination (GO:0006312)3.05899208
78ncRNA catabolic process (GO:0034661)3.05108965
79regulation of histone H3-K9 methylation (GO:0051570)3.04834033
80kinetochore assembly (GO:0051382)3.04196350
81somatic hypermutation of immunoglobulin genes (GO:0016446)3.03669815
82somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03669815
83telomere maintenance via recombination (GO:0000722)3.02928345
84protein K6-linked ubiquitination (GO:0085020)3.02444693
85regulation of translational fidelity (GO:0006450)3.01296105
86regulation of centrosome cycle (GO:0046605)3.01281373
87regulation of DNA endoreduplication (GO:0032875)3.00975858
88regulation of chromosome segregation (GO:0051983)3.00205550
89regulation of mitotic sister chromatid separation (GO:0010965)2.99338679
90regulation of mitotic sister chromatid segregation (GO:0033047)2.99338679
91regulation of sister chromatid segregation (GO:0033045)2.99338679
92regulation of sister chromatid cohesion (GO:0007063)2.98404250
93negative regulation of chromosome segregation (GO:0051985)2.98309611
94establishment of viral latency (GO:0019043)2.98272503
95telomere maintenance via semi-conservative replication (GO:0032201)2.98204731
96regulation of nuclear cell cycle DNA replication (GO:0033262)2.98002719
97regulation of centriole replication (GO:0046599)2.96984577
98regulation of telomere maintenance via telomerase (GO:0032210)2.96671194
99DNA ligation (GO:0006266)2.96550221
100negative regulation of mRNA processing (GO:0050686)2.94294049
101telomere maintenance via telomerase (GO:0007004)2.93188790
102histone arginine methylation (GO:0034969)2.92687268
103DNA catabolic process, exonucleolytic (GO:0000738)2.92496839
104kinetochore organization (GO:0051383)2.90290202
105spindle checkpoint (GO:0031577)2.90271011
106regulation of gene silencing (GO:0060968)2.89390052
107DNA replication-independent nucleosome assembly (GO:0006336)2.89218700
108DNA replication-independent nucleosome organization (GO:0034724)2.89218700
109rRNA processing (GO:0006364)2.89186761
110regulation of translational termination (GO:0006449)2.88816687
111establishment of chromosome localization (GO:0051303)2.87124493
112chromatin assembly (GO:0031497)2.86154312
113spliceosomal snRNP assembly (GO:0000387)2.85796930
114trophectodermal cell differentiation (GO:0001829)2.85739520
115histone H4-K12 acetylation (GO:0043983)2.85233263
116telomere maintenance via telomere lengthening (GO:0010833)2.85193341
117negative regulation of RNA splicing (GO:0033119)2.85127342
118mRNA transport (GO:0051028)2.84083713
119mitotic spindle checkpoint (GO:0071174)2.84018483
120chromatin assembly or disassembly (GO:0006333)2.83839025
121negative regulation of mitotic sister chromatid segregation (GO:0033048)2.83794365
122negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.83794365
123negative regulation of sister chromatid segregation (GO:0033046)2.83794365
124negative regulation of mitotic sister chromatid separation (GO:2000816)2.83794365
125regulation of helicase activity (GO:0051095)2.83566695
126RNA splicing, via transesterification reactions (GO:0000375)2.83198926
127rRNA metabolic process (GO:0016072)2.82917474
128protein localization to chromosome (GO:0034502)2.82230135
129RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.81881776
130mRNA splicing, via spliceosome (GO:0000398)2.81881776
131spindle assembly checkpoint (GO:0071173)2.80540091
132negative regulation of mitosis (GO:0045839)2.80282089
133mitotic G2/M transition checkpoint (GO:0044818)2.79978279
134regulation of mitotic metaphase/anaphase transition (GO:0030071)2.79156862
135mitotic spindle assembly checkpoint (GO:0007094)2.78797229
136regulation of hippo signaling (GO:0035330)2.78750750
137peptidyl-arginine N-methylation (GO:0035246)2.78429920
138peptidyl-arginine methylation (GO:0018216)2.78429920
139negative regulation of mRNA metabolic process (GO:1903312)2.77926748
140nucleotide-excision repair, DNA gap filling (GO:0006297)2.76527343
141spliceosomal tri-snRNP complex assembly (GO:0000244)2.76196662
142synapsis (GO:0007129)2.70346580
143positive regulation of SMAD protein import into nucleus (GO:0060391)2.67044882
144response to X-ray (GO:0010165)2.65231299
145histone H2A acetylation (GO:0043968)2.64225994

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.72760943
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.59419875
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.08959042
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53849955
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.12103933
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04912173
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98253168
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74095081
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.45679412
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42668571
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.38260736
12AR_21909140_ChIP-Seq_LNCAP_Human2.34194147
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.22977310
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21684119
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.17044065
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16706361
17* MYC_22102868_ChIP-Seq_BL_Human2.14863405
18POU5F1_16153702_ChIP-ChIP_HESCs_Human2.11246970
19XRN2_22483619_ChIP-Seq_HELA_Human2.09647950
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.07611188
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.04945149
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.04281160
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03354912
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03243067
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.00618823
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.00618823
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.00618823
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97385948
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.97296878
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.94959823
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94179953
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.92015910
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88602932
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.88013791
35EWS_26573619_Chip-Seq_HEK293_Human1.87970729
36ZNF274_21170338_ChIP-Seq_K562_Hela1.82847768
37SOX2_16153702_ChIP-ChIP_HESCs_Human1.81628815
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77190824
39NANOG_16153702_ChIP-ChIP_HESCs_Human1.74774920
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.72713209
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.68830020
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64035144
43VDR_23849224_ChIP-Seq_CD4+_Human1.60631839
44TTF2_22483619_ChIP-Seq_HELA_Human1.60021106
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58800607
46KDM5A_27292631_Chip-Seq_BREAST_Human1.58357983
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58217339
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58141666
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57004577
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.55035270
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54153093
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53683295
53NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.53611763
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.53422300
55GABP_19822575_ChIP-Seq_HepG2_Human1.52867059
56ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50926518
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50795937
58MYC_18940864_ChIP-ChIP_HL60_Human1.50624770
59FOXP3_21729870_ChIP-Seq_TREG_Human1.48149784
60FUS_26573619_Chip-Seq_HEK293_Human1.47811240
61CIITA_25753668_ChIP-Seq_RAJI_Human1.47793085
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45239593
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42576388
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40883152
65DCP1A_22483619_ChIP-Seq_HELA_Human1.39899766
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39015337
67TCF3_18692474_ChIP-Seq_MESCs_Mouse1.38356573
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36913097
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36369612
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.34290881
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33281776
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32498051
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31508729
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30001870
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27267041
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26233555
77SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.25895337
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25844601
79VDR_22108803_ChIP-Seq_LS180_Human1.25650618
80IGF1R_20145208_ChIP-Seq_DFB_Human1.24270781
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.20756960
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19007446
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18574346
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.15417288
85* P300_19829295_ChIP-Seq_ESCs_Human1.13730576
86YY1_21170310_ChIP-Seq_MESCs_Mouse1.13704536
87* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12725541
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11007389
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10307179
90NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08880493
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06992646
92* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06566259
93HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05748144
94ELK1_19687146_ChIP-ChIP_HELA_Human1.04192709
95NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.04146313
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01945461
97POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01716361
98POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01714973
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01451931
100TFEB_21752829_ChIP-Seq_HELA_Human1.01170154
101TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00891762
102SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00574495
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97808269
104SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97597024
105ZNF263_19887448_ChIP-Seq_K562_Human0.97526707
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96541622
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96513211
108OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96472055
109POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.95870646
110TAF15_26573619_Chip-Seq_HEK293_Human0.95713207
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95573497
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95200117
113SRF_21415370_ChIP-Seq_HL-1_Mouse0.94593405
114FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93339921
115CHD1_26751641_Chip-Seq_LNCaP_Human0.93210713
116GATA1_26923725_Chip-Seq_HPCs_Mouse0.92690620
117HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92614715
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92286914
119VDR_21846776_ChIP-Seq_THP-1_Human0.92206639
120IRF1_19129219_ChIP-ChIP_H3396_Human0.91877205
121PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91572158
122SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91376774
123GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90663102
124NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90205273
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88912020
126SOX17_20123909_ChIP-Seq_XEN_Mouse0.88664044
127RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88401528
128EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87050096
129PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84785186
130TBX3_20139965_ChIP-Seq_ESCs_Mouse0.80861673
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80833659
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80131233
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80131233
134TBX3_20139965_ChIP-Seq_MESCs_Mouse0.79634487
135POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77843486

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.27446302
2MP0008057_abnormal_DNA_replication3.99344691
3MP0003111_abnormal_nucleus_morphology3.91910901
4MP0004957_abnormal_blastocyst_morpholog3.81095520
5MP0010094_abnormal_chromosome_stability3.69739457
6MP0003077_abnormal_cell_cycle3.40834934
7MP0000566_synostosis2.66464225
8MP0001730_embryonic_growth_arrest2.58540531
9MP0010030_abnormal_orbit_morphology2.51873958
10MP0002254_reproductive_system_inflammat2.48918114
11MP0008058_abnormal_DNA_repair2.48327849
12MP0003123_paternal_imprinting2.47957893
13MP0010352_gastrointestinal_tract_polyps2.39459374
14MP0000350_abnormal_cell_proliferation2.33614537
15MP0005380_embryogenesis_phenotype2.33023364
16MP0001672_abnormal_embryogenesis/_devel2.33023364
17MP0003890_abnormal_embryonic-extraembry2.28063517
18MP0008932_abnormal_embryonic_tissue2.14928162
19MP0003984_embryonic_growth_retardation2.13597483
20MP0008007_abnormal_cellular_replicative2.12490621
21MP0002088_abnormal_embryonic_growth/wei2.11351000
22MP0005076_abnormal_cell_differentiation2.06461597
23MP0002084_abnormal_developmental_patter2.05008068
24MP0001697_abnormal_embryo_size2.01796718
25MP0002085_abnormal_embryonic_tissue2.00950557
26MP0004197_abnormal_fetal_growth/weight/1.93893893
27MP0002086_abnormal_extraembryonic_tissu1.88566364
28MP0010307_abnormal_tumor_latency1.82495608
29MP0002396_abnormal_hematopoietic_system1.79594835
30MP0001293_anophthalmia1.78274950
31MP0003119_abnormal_digestive_system1.75827284
32MP0002653_abnormal_ependyma_morphology1.72352801
33MP0003121_genomic_imprinting1.71641868
34MP0000537_abnormal_urethra_morphology1.71362975
35MP0002080_prenatal_lethality1.70669037
36MP0003567_abnormal_fetal_cardiomyocyte1.65908498
37MP0009053_abnormal_anal_canal1.64130060
38MP0009697_abnormal_copulation1.59935586
39MP0003705_abnormal_hypodermis_morpholog1.59489141
40MP0003786_premature_aging1.52296263
41MP0001188_hyperpigmentation1.50992720
42MP0008877_abnormal_DNA_methylation1.48331339
43MP0003718_maternal_effect1.38650877
44MP0002736_abnormal_nociception_after1.38039519
45MP0002234_abnormal_pharynx_morphology1.35960547
46MP0000428_abnormal_craniofacial_morphol1.34915282
47MP0009672_abnormal_birth_weight1.34749083
48MP0003937_abnormal_limbs/digits/tail_de1.32098784
49MP0001849_ear_inflammation1.30067897
50MP0005394_taste/olfaction_phenotype1.26062428
51MP0005499_abnormal_olfactory_system1.26062428
52MP0009278_abnormal_bone_marrow1.24405311
53MP0000490_abnormal_crypts_of1.23240417
54MP0009703_decreased_birth_body1.22126834
55MP0000313_abnormal_cell_death1.21479899
56MP0003646_muscle_fatigue1.21048194
57MP0002751_abnormal_autonomic_nervous1.20898418
58MP0003136_yellow_coat_color1.20353114
59MP0004133_heterotaxia1.19349483
60MP0002111_abnormal_tail_morphology1.16183378
61MP0002102_abnormal_ear_morphology1.15099877
62MP0002092_abnormal_eye_morphology1.13522416
63MP0003115_abnormal_respiratory_system1.12923528
64MP0003315_abnormal_perineum_morphology1.10719286
65MP0003935_abnormal_craniofacial_develop1.10003213
66MP0000579_abnormal_nail_morphology1.07601791
67MP0000432_abnormal_head_morphology1.07425067
68MP0004808_abnormal_hematopoietic_stem1.06466000
69MP0002697_abnormal_eye_size1.06435653
70MP0001485_abnormal_pinna_reflex1.03951230
71MP0000733_abnormal_muscle_development1.03711710
72MP0001529_abnormal_vocalization1.02604251
73MP0006292_abnormal_olfactory_placode1.02329728
74MP0000631_abnormal_neuroendocrine_gland1.01191430
75MP0006072_abnormal_retinal_apoptosis1.00885192
76MP0002019_abnormal_tumor_incidence1.00639143
77MP0006035_abnormal_mitochondrial_morpho0.98537773
78MP0001286_abnormal_eye_development0.98211855
79MP0002249_abnormal_larynx_morphology0.97819312
80MP0004264_abnormal_extraembryonic_tissu0.97227365
81MP0003787_abnormal_imprinting0.96546369
82MP0002938_white_spotting0.95818906
83MP0001177_atelectasis0.93855589
84MP0003878_abnormal_ear_physiology0.92371185
85MP0005377_hearing/vestibular/ear_phenot0.92371185
86MP0003755_abnormal_palate_morphology0.91287285
87MP0003941_abnormal_skin_development0.90826395
88MP0002210_abnormal_sex_determination0.89335333
89MP0002925_abnormal_cardiovascular_devel0.87555885
90MP0003122_maternal_imprinting0.87308995
91MP0003861_abnormal_nervous_system0.84266676
92MP0002932_abnormal_joint_morphology0.84173400
93MP0001145_abnormal_male_reproductive0.83180007
94MP0001299_abnormal_eye_distance/0.81297423
95MP0000049_abnormal_middle_ear0.80779977
96MP0005397_hematopoietic_system_phenotyp0.80417206
97MP0001545_abnormal_hematopoietic_system0.80417206
98MP0003942_abnormal_urinary_system0.79668463
99MP0001915_intracranial_hemorrhage0.79333948
100MP0000750_abnormal_muscle_regeneration0.79252298
101MP0005395_other_phenotype0.79238788
102MP0009333_abnormal_splenocyte_physiolog0.78150487
103MP0003566_abnormal_cell_adhesion0.77811462
104MP0000778_abnormal_nervous_system0.74198888
105MP0005384_cellular_phenotype0.73944022
106MP0003938_abnormal_ear_development0.73433093
107MP0001984_abnormal_olfaction0.73333194
108MP0001346_abnormal_lacrimal_gland0.73049234
109MP0005621_abnormal_cell_physiology0.72729422
110MP0002114_abnormal_axial_skeleton0.71573735
111MP0008789_abnormal_olfactory_epithelium0.70946272
112MP0002127_abnormal_cardiovascular_syste0.70886148
113MP0005367_renal/urinary_system_phenotyp0.70364621
114MP0000516_abnormal_urinary_system0.70364621
115MP0000647_abnormal_sebaceous_gland0.69792147
116MP0008770_decreased_survivor_rate0.69512136
117MP0002116_abnormal_craniofacial_bone0.69280316
118MP0000703_abnormal_thymus_morphology0.68374230
119MP0005023_abnormal_wound_healing0.68086728
120MP0001119_abnormal_female_reproductive0.67986765
121MP0003221_abnormal_cardiomyocyte_apopto0.67881079
122MP0004233_abnormal_muscle_weight0.67837687
123MP0005391_vision/eye_phenotype0.67636046
124MP0003283_abnormal_digestive_organ0.67004718
125MP0002081_perinatal_lethality0.66959037
126MP0000266_abnormal_heart_morphology0.65599975
127MP0003698_abnormal_male_reproductive0.65573739
128MP0000653_abnormal_sex_gland0.65366720
129MP0003936_abnormal_reproductive_system0.64180999
130MP0003186_abnormal_redox_activity0.63459279
131MP0001929_abnormal_gametogenesis0.60884428
132MP0000762_abnormal_tongue_morphology0.59732965
133MP0000627_abnormal_mammary_gland0.58989890
134MP0002233_abnormal_nose_morphology0.58880733

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.29151633
2Birth length less than 3rd percentile (HP:0003561)3.95097186
3Breast hypoplasia (HP:0003187)3.42665098
4Abnormality of the labia minora (HP:0012880)3.42529651
5Selective tooth agenesis (HP:0001592)3.36840922
6Impulsivity (HP:0100710)3.34068434
7Patellar aplasia (HP:0006443)3.24799342
8Medulloblastoma (HP:0002885)3.13362149
9Aplasia/Hypoplasia of the patella (HP:0006498)3.07840295
10Astrocytoma (HP:0009592)3.07543184
11Abnormality of the astrocytes (HP:0100707)3.07543184
12Abnormal lung lobation (HP:0002101)3.00880437
13Absent radius (HP:0003974)2.99379390
14Septo-optic dysplasia (HP:0100842)2.95086430
15Chromsome breakage (HP:0040012)2.90335913
16Facial hemangioma (HP:0000329)2.85167766
17Absent forearm bone (HP:0003953)2.81656253
18Aplasia involving forearm bones (HP:0009822)2.81656253
19Aplasia/hypoplasia of the humerus (HP:0006507)2.80601940
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.80289036
21Carpal bone hypoplasia (HP:0001498)2.78095730
22Colon cancer (HP:0003003)2.77499378
23Glioma (HP:0009733)2.75301013
24Rib fusion (HP:0000902)2.74471666
25Abnormal number of incisors (HP:0011064)2.73589235
26Nephroblastoma (Wilms tumor) (HP:0002667)2.69029917
27Rhabdomyosarcoma (HP:0002859)2.66008658
28Short humerus (HP:0005792)2.64093499
29Proximal placement of thumb (HP:0009623)2.57765693
30Intestinal atresia (HP:0011100)2.55637171
31Deviation of the thumb (HP:0009603)2.54504785
32Embryonal renal neoplasm (HP:0011794)2.54474640
33Neoplasm of striated muscle (HP:0009728)2.49713998
34Short 4th metacarpal (HP:0010044)2.48121898
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.48121898
36Meckel diverticulum (HP:0002245)2.46887421
37Hyperglycinemia (HP:0002154)2.45489360
38Oral leukoplakia (HP:0002745)2.45135858
39Rough bone trabeculation (HP:0100670)2.44821019
40Abnormality of the ileum (HP:0001549)2.42991458
41Neoplasm of the oral cavity (HP:0100649)2.41532339
42Triphalangeal thumb (HP:0001199)2.41090876
43Abnormality of the duodenum (HP:0002246)2.40258885
44Ectopic kidney (HP:0000086)2.38530208
45Neoplasm of the adrenal cortex (HP:0100641)2.36268374
46Missing ribs (HP:0000921)2.35664808
47Shawl scrotum (HP:0000049)2.35264483
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.34927996
49Abnormality of chromosome stability (HP:0003220)2.34307847
50Bifid tongue (HP:0010297)2.32686116
51Multiple enchondromatosis (HP:0005701)2.30071617
52Atresia of the external auditory canal (HP:0000413)2.29730362
53Prominent nose (HP:0000448)2.25508516
54Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.25332466
55Cortical dysplasia (HP:0002539)2.22948082
56Sparse lateral eyebrow (HP:0005338)2.21425030
57Abnormality of the anterior horn cell (HP:0006802)2.20272584
58Degeneration of anterior horn cells (HP:0002398)2.20272584
59Increased nuchal translucency (HP:0010880)2.19060658
60Abnormality of the preputium (HP:0100587)2.18799244
61Methylmalonic acidemia (HP:0002912)2.18598368
62Renal duplication (HP:0000075)2.18009271
63Anal stenosis (HP:0002025)2.16930209
64Homocystinuria (HP:0002156)2.16155813
65Abnormality of homocysteine metabolism (HP:0010919)2.16155813
66Long eyelashes (HP:0000527)2.14977000
67Absent thumb (HP:0009777)2.13838899
68Bilateral microphthalmos (HP:0007633)2.13718618
69Supernumerary spleens (HP:0009799)2.12282980
70Esophageal atresia (HP:0002032)2.10121816
71Pendular nystagmus (HP:0012043)2.09116095
72Stenosis of the external auditory canal (HP:0000402)2.08887403
73Gastrointestinal atresia (HP:0002589)2.08466693
74Sloping forehead (HP:0000340)2.07398232
75Neoplasm of the pancreas (HP:0002894)2.06423890
76Absent septum pellucidum (HP:0001331)2.04821492
77Trismus (HP:0000211)2.03645720
78Aplasia/Hypoplasia of the sternum (HP:0006714)2.03412192
79Hyperglycinuria (HP:0003108)2.03190252
80Tracheoesophageal fistula (HP:0002575)2.02188636
81Abnormality of the septum pellucidum (HP:0007375)2.00023010
82Pancreatic islet-cell hyperplasia (HP:0004510)1.99546637
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99348906
84Basal cell carcinoma (HP:0002671)1.99224884
85Abnormality of serine family amino acid metabolism (HP:0010894)1.98070551
86Abnormality of glycine metabolism (HP:0010895)1.98070551
87Preaxial foot polydactyly (HP:0001841)1.97826254
88Abnormality of abdominal situs (HP:0011620)1.96947126
89Abdominal situs inversus (HP:0003363)1.96947126
90Hepatoblastoma (HP:0002884)1.96745867
91Intestinal fistula (HP:0100819)1.96735885
92Rectal fistula (HP:0100590)1.95389370
93Rectovaginal fistula (HP:0000143)1.95389370
94Abnormality of serum amino acid levels (HP:0003112)1.93432348
95Facial cleft (HP:0002006)1.92566714
96Dandy-Walker malformation (HP:0001305)1.92313155
97Preaxial hand polydactyly (HP:0001177)1.90959986
98Cerebral hypomyelination (HP:0006808)1.89246645
99Broad thumb (HP:0011304)1.88222215
100Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.87798255
101Short 1st metacarpal (HP:0010034)1.87798255
102Myelodysplasia (HP:0002863)1.87757656
103Abnormality of methionine metabolism (HP:0010901)1.87504901
104Duodenal stenosis (HP:0100867)1.87135231
105Small intestinal stenosis (HP:0012848)1.87135231
106Cafe-au-lait spot (HP:0000957)1.86982631
107Premature graying of hair (HP:0002216)1.85794571
108Vertebral fusion (HP:0002948)1.84760189
109Pelvic girdle muscle weakness (HP:0003749)1.84574527
110Skin tags (HP:0010609)1.83957848
111Reticulocytopenia (HP:0001896)1.83957493
112Methylmalonic aciduria (HP:0012120)1.83692287
113Renal hypoplasia (HP:0000089)1.83151231
114Hypoplastic female external genitalia (HP:0012815)1.82487742
115Abnormal hair whorl (HP:0010721)1.82485327
116Duplication of thumb phalanx (HP:0009942)1.81882919
117Horseshoe kidney (HP:0000085)1.81848987
118Preauricular skin tag (HP:0000384)1.81822493
119Short thumb (HP:0009778)1.81682002
120Biliary tract neoplasm (HP:0100574)1.81250044
121Gastrointestinal carcinoma (HP:0002672)1.80823978
122Malignant gastrointestinal tract tumors (HP:0006749)1.80823978
123Optic nerve hypoplasia (HP:0000609)1.80664544
124Abnormality of the 4th metacarpal (HP:0010012)1.79305438
125Anophthalmia (HP:0000528)1.79282032
126High anterior hairline (HP:0009890)1.78374272
127Abnormality of the carotid arteries (HP:0005344)1.78124054
128Urethral obstruction (HP:0000796)1.77662769
129Volvulus (HP:0002580)1.77218124
130Breast aplasia (HP:0100783)1.77138286
131Anal atresia (HP:0002023)1.76910948
132Supernumerary bones of the axial skeleton (HP:0009144)1.76832426
133Short phalanx of the thumb (HP:0009660)1.76511321
134Supernumerary ribs (HP:0005815)1.75965420
135Oligodactyly (HP:0012165)1.75929091
136Hemivertebrae (HP:0002937)1.75493016
137Abnormal trabecular bone morphology (HP:0100671)1.75320382
138Squamous cell carcinoma (HP:0002860)1.75100234
139Agnosia (HP:0010524)1.75094597
140Clubbing of toes (HP:0100760)1.75093999
141Pseudobulbar signs (HP:0002200)1.74668993
142Spinal muscular atrophy (HP:0007269)1.73312656
143Fused cervical vertebrae (HP:0002949)1.73190950
144Aqueductal stenosis (HP:0002410)1.72531877
145Neoplasm of the adrenal gland (HP:0100631)1.71211428
146Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70081784
147Neoplasm of the colon (HP:0100273)1.69934448
148Pancreatic cysts (HP:0001737)1.66596532
149Labial hypoplasia (HP:0000066)1.65389844
150Choanal atresia (HP:0000453)1.65203613
151Cupped ear (HP:0000378)1.64989950
152Depressed nasal tip (HP:0000437)1.61040918
153Embryonal neoplasm (HP:0002898)1.60497643
154Scrotal hypoplasia (HP:0000046)1.60452480

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.05678117
2CDC73.82935880
3WEE13.36078435
4BUB13.29431551
5NEK23.10880434
6TNIK2.89537930
7VRK22.77405445
8TAF12.66085148
9TSSK62.47067130
10TTK2.42405757
11EPHA22.36664376
12TRIM282.26901698
13SRPK12.24923666
14MAP3K102.22790774
15NUAK12.18755219
16LATS22.07824343
17ACVR1B1.98071764
18LATS11.97618908
19WNK31.97484738
20EEF2K1.93581024
21CDK71.91812774
22STK241.86251919
23MKNK11.84237623
24PLK11.80390391
25AKT31.78225763
26PBK1.68001959
27CDK41.67083480
28NEK11.65588399
29EIF2AK11.65258959
30RPS6KB21.63872948
31CHEK21.63504467
32PLK41.60877265
33BRSK21.59989062
34PASK1.53953915
35CHEK11.51953310
36ATR1.51235234
37MKNK21.48665420
38DYRK31.48256693
39BRD41.48229120
40PLK31.45108927
41STK31.43526463
42AURKB1.42388882
43ALK1.41032972
44BMPR1B1.35360793
45STK101.32471045
46DYRK21.31765862
47CASK1.29852345
48MTOR1.29642309
49RPS6KA41.26763246
50MAP3K81.23866412
51STK38L1.23163684
52MST41.20799881
53ICK1.13312431
54PAK41.11439717
55CDK21.10980220
56STK391.08708625
57NME11.06602989
58AURKA1.03709540
59CDK61.03024950
60ATM1.00407106
61PIM11.00167961
62BRSK10.97223562
63CSNK1G10.96933369
64SMG10.96471327
65TESK20.94013957
66STK160.92405834
67MELK0.92241139
68FGFR20.92020286
69EIF2AK20.91450918
70PNCK0.90571357
71EIF2AK30.83753674
72SCYL20.82056541
73TGFBR10.81764111
74AKT20.80003229
75PAK20.79804944
76PKN20.79550547
77CDK10.77440045
78CAMK1G0.74422927
79FGFR10.74345011
80BMX0.72446352
81STK40.72300420
82BCR0.71823405
83CSNK1G20.70914063
84WNK40.70415875
85VRK10.69170841
86CSNK1E0.68948543
87TLK10.68611889
88PAK10.68376925
89ZAK0.66926891
90CCNB10.66521131
91FRK0.66467876
92NME20.66004157
93CSNK1G30.64455266
94TYRO30.64179718
95PLK20.62181388
96PDGFRA0.62168532
97NLK0.62017140
98CSNK2A20.60358046
99PRKCI0.59180157
100CDK80.56972057
101CDK90.51803739
102OXSR10.51253882
103CSNK1A1L0.49383636
104FLT30.48600269
105CSNK1D0.47894945
106MAP3K110.46442845
107TRIB30.45734478
108PRKCG0.45624349
109TTN0.45159063
110DMPK0.45085883
111CAMK1D0.44479294
112GRK10.44036916
113CSNK2A10.43711655
114ERBB40.42958356
115RPS6KA10.42796799
116EPHA40.42695679
117ERBB30.42122634
118MAPK140.41030995
119CHUK0.40367713
120MAP2K30.39111759
121PRKDC0.38760556
122PINK10.37138414
123MARK30.36879684
124MAPK10.36362692
125RPS6KA50.36139314
126MAPK130.36059083
127MAP4K20.35834157
128LRRK20.35255427
129MET0.35127387
130AKT10.35087226
131DDR20.35073109
132CDK30.34756841
133GSK3B0.34718060
134MAP3K30.34533791
135INSRR0.33298174
136MAP2K20.33051800
137MINK10.32441008
138GRK60.30089613
139KSR10.29713990
140BRAF0.29559804
141MAPK100.29322176
142MAP3K40.28944160
143CDK190.28603988
144PTK20.27842634
145CSNK1A10.27540195
146PTK60.27092899
147MAPKAPK50.24374583

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.27990493
2DNA replication_Homo sapiens_hsa030303.91666205
3RNA transport_Homo sapiens_hsa030133.63837620
4Mismatch repair_Homo sapiens_hsa034303.49409247
5Spliceosome_Homo sapiens_hsa030403.31764595
6RNA polymerase_Homo sapiens_hsa030202.92061227
7Cell cycle_Homo sapiens_hsa041102.87705797
8One carbon pool by folate_Homo sapiens_hsa006702.84097471
9Base excision repair_Homo sapiens_hsa034102.69979054
10mRNA surveillance pathway_Homo sapiens_hsa030152.34011708
11Nucleotide excision repair_Homo sapiens_hsa034202.30990821
12Homologous recombination_Homo sapiens_hsa034402.28931493
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.25312597
14Vitamin B6 metabolism_Homo sapiens_hsa007502.21395673
15Fanconi anemia pathway_Homo sapiens_hsa034602.01411477
16RNA degradation_Homo sapiens_hsa030181.94114377
17Pyrimidine metabolism_Homo sapiens_hsa002401.92704759
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82702024
19Basal transcription factors_Homo sapiens_hsa030221.79169219
20Protein export_Homo sapiens_hsa030601.77613601
21p53 signaling pathway_Homo sapiens_hsa041151.76244788
22Ribosome_Homo sapiens_hsa030101.73874597
23Steroid biosynthesis_Homo sapiens_hsa001001.68560874
24Propanoate metabolism_Homo sapiens_hsa006401.61763381
25Non-homologous end-joining_Homo sapiens_hsa034501.52995673
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50126009
27Proteasome_Homo sapiens_hsa030501.49621625
28Basal cell carcinoma_Homo sapiens_hsa052171.36504697
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36493668
30Folate biosynthesis_Homo sapiens_hsa007901.30716252
31Hippo signaling pathway_Homo sapiens_hsa043901.28894212
32MicroRNAs in cancer_Homo sapiens_hsa052061.28025532
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.27996452
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20139338
35Fatty acid elongation_Homo sapiens_hsa000621.16540866
36Pyruvate metabolism_Homo sapiens_hsa006201.14613856
37Biosynthesis of amino acids_Homo sapiens_hsa012301.13313850
38Selenocompound metabolism_Homo sapiens_hsa004501.10784801
39Epstein-Barr virus infection_Homo sapiens_hsa051691.10259606
40Viral carcinogenesis_Homo sapiens_hsa052031.05578010
41Hedgehog signaling pathway_Homo sapiens_hsa043401.03225341
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01326935
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.99731149
44Purine metabolism_Homo sapiens_hsa002300.97519127
45Huntingtons disease_Homo sapiens_hsa050160.96786986
46Oocyte meiosis_Homo sapiens_hsa041140.96568405
47Herpes simplex infection_Homo sapiens_hsa051680.95315449
48Notch signaling pathway_Homo sapiens_hsa043300.95223824
49HTLV-I infection_Homo sapiens_hsa051660.93775080
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93213292
51Systemic lupus erythematosus_Homo sapiens_hsa053220.93089804
52Parkinsons disease_Homo sapiens_hsa050120.93002270
53Small cell lung cancer_Homo sapiens_hsa052220.92095576
54mTOR signaling pathway_Homo sapiens_hsa041500.91131609
55TGF-beta signaling pathway_Homo sapiens_hsa043500.89569784
56Thyroid cancer_Homo sapiens_hsa052160.88901645
57Lysine degradation_Homo sapiens_hsa003100.88786635
58Adherens junction_Homo sapiens_hsa045200.85700027
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83410820
60Oxidative phosphorylation_Homo sapiens_hsa001900.82232962
61Pentose phosphate pathway_Homo sapiens_hsa000300.81720612
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.80134489
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78981910
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74947188
65Sulfur relay system_Homo sapiens_hsa041220.72203247
66Antigen processing and presentation_Homo sapiens_hsa046120.69842063
67Colorectal cancer_Homo sapiens_hsa052100.67416440
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66252286
69Chronic myeloid leukemia_Homo sapiens_hsa052200.66235042
70Glutathione metabolism_Homo sapiens_hsa004800.65558601
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63443369
72Bladder cancer_Homo sapiens_hsa052190.62506226
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60719234
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58366959
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.58279475
76Wnt signaling pathway_Homo sapiens_hsa043100.56108074
77Prostate cancer_Homo sapiens_hsa052150.54812802
78Fatty acid metabolism_Homo sapiens_hsa012120.54193729
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52917451
80Pathways in cancer_Homo sapiens_hsa052000.52838903
81Phototransduction_Homo sapiens_hsa047440.52378776
82Legionellosis_Homo sapiens_hsa051340.52257376
83Viral myocarditis_Homo sapiens_hsa054160.52188674
84Metabolic pathways_Homo sapiens_hsa011000.51755921
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.51187904
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50772262
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50684693
88N-Glycan biosynthesis_Homo sapiens_hsa005100.50526868
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49617010
90Butanoate metabolism_Homo sapiens_hsa006500.49042707
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48705986
92Acute myeloid leukemia_Homo sapiens_hsa052210.47589081
93Tight junction_Homo sapiens_hsa045300.47371674
94Proteoglycans in cancer_Homo sapiens_hsa052050.47096159
95Apoptosis_Homo sapiens_hsa042100.45219474
96beta-Alanine metabolism_Homo sapiens_hsa004100.44371882
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43515294
98Endometrial cancer_Homo sapiens_hsa052130.41936293
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40668422
100Nicotine addiction_Homo sapiens_hsa050330.40572878
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40534489
102Carbon metabolism_Homo sapiens_hsa012000.39412804
103Arginine biosynthesis_Homo sapiens_hsa002200.39307361
104Alzheimers disease_Homo sapiens_hsa050100.38311649
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38150794
106Fructose and mannose metabolism_Homo sapiens_hsa000510.38097695
107Hepatitis B_Homo sapiens_hsa051610.37808011
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37731664
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36302824
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.35707557
111HIF-1 signaling pathway_Homo sapiens_hsa040660.32656730
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31922207
113FoxO signaling pathway_Homo sapiens_hsa040680.31899797
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30937853
115Tryptophan metabolism_Homo sapiens_hsa003800.28660921
116Vitamin digestion and absorption_Homo sapiens_hsa049770.28170778
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.27113873
118Renal cell carcinoma_Homo sapiens_hsa052110.26727851
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26227369
120Regulation of autophagy_Homo sapiens_hsa041400.25372764
121Non-small cell lung cancer_Homo sapiens_hsa052230.24857374
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24663973
123Melanoma_Homo sapiens_hsa052180.23390101
124AMPK signaling pathway_Homo sapiens_hsa041520.23351782
125Taste transduction_Homo sapiens_hsa047420.22943517
126Arginine and proline metabolism_Homo sapiens_hsa003300.22827107
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21957083
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19709049
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.19535978
130Fatty acid degradation_Homo sapiens_hsa000710.18175167
131Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18138271
132Nitrogen metabolism_Homo sapiens_hsa009100.16992258
133Retinol metabolism_Homo sapiens_hsa008300.16421179
134Fat digestion and absorption_Homo sapiens_hsa049750.15892308
135Ether lipid metabolism_Homo sapiens_hsa005650.15881849
136Caffeine metabolism_Homo sapiens_hsa002320.14883604
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14647859
138Shigellosis_Homo sapiens_hsa051310.14583432
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.13746238
140Pancreatic cancer_Homo sapiens_hsa052120.13522229
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.12177407
142Alcoholism_Homo sapiens_hsa050340.11098901
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10844344

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