BEND3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.49064047
2nuclear pore organization (GO:0006999)5.25460518
3mitotic sister chromatid cohesion (GO:0007064)4.84373600
4histone H3-K4 trimethylation (GO:0080182)4.55106096
5positive regulation of histone H3-K4 methylation (GO:0051571)4.39711712
6regulation of acrosome reaction (GO:0060046)4.22956555
7regulation of RNA export from nucleus (GO:0046831)4.08323331
8pyrimidine dimer repair (GO:0006290)4.04638073
9multicellular organism reproduction (GO:0032504)3.93015876
10pore complex assembly (GO:0046931)3.83807195
11regulation of histone H3-K4 methylation (GO:0051569)3.82071609
12histone H2A acetylation (GO:0043968)3.76730210
13DNA double-strand break processing (GO:0000729)3.72105329
14regulation of Golgi to plasma membrane protein transport (GO:0042996)3.59430634
15binding of sperm to zona pellucida (GO:0007339)3.51135302
16positive regulation of mitotic sister chromatid separation (GO:1901970)3.50614155
17positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.50614155
18positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.50614155
19snRNA transcription (GO:0009301)3.38975221
20positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.23156143
21histone H4-K8 acetylation (GO:0043982)3.21318340
22histone H4-K5 acetylation (GO:0043981)3.21318340
23histone H3-K4 methylation (GO:0051568)3.19387285
24positive regulation of RNA splicing (GO:0033120)3.17779733
25peptidyl-lysine trimethylation (GO:0018023)3.15840700
26sperm-egg recognition (GO:0035036)3.14105883
27positive regulation of DNA-templated transcription, initiation (GO:2000144)3.12732046
28mitotic nuclear envelope disassembly (GO:0007077)3.11894456
29histone H2B ubiquitination (GO:0033523)3.11084165
30monoubiquitinated protein deubiquitination (GO:0035520)3.08883948
31DNA synthesis involved in DNA repair (GO:0000731)3.08279419
32regulation of gene expression by genetic imprinting (GO:0006349)3.08164132
33mRNA cleavage (GO:0006379)3.07474400
34regulation of hippo signaling (GO:0035330)3.06205901
35mitotic chromosome condensation (GO:0007076)3.04360621
36histone deubiquitination (GO:0016578)3.03793642
37neural tube formation (GO:0001841)3.02028102
38regulation of translational fidelity (GO:0006450)2.99671217
39regulation of centrosome cycle (GO:0046605)2.97489541
40regulation of DNA damage checkpoint (GO:2000001)2.96805327
41regulation of nucleobase-containing compound transport (GO:0032239)2.96323872
42stress granule assembly (GO:0034063)2.94051880
43nuclear envelope disassembly (GO:0051081)2.90397770
44membrane disassembly (GO:0030397)2.90397770
45regulation of retinoic acid receptor signaling pathway (GO:0048385)2.88557960
46sister chromatid cohesion (GO:0007062)2.88429872
47positive regulation of histone methylation (GO:0031062)2.86289788
48regulation of histone methylation (GO:0031060)2.84117713
49histone H4-K16 acetylation (GO:0043984)2.83133342
50sister chromatid segregation (GO:0000819)2.82604390
51DNA unwinding involved in DNA replication (GO:0006268)2.78645112
52positive regulation of dendritic spine morphogenesis (GO:0061003)2.78527781
53sympathetic nervous system development (GO:0048485)2.78355611
54histone H4 acetylation (GO:0043967)2.77645198
55regulation of histone H3-K9 methylation (GO:0051570)2.74455428
56central nervous system projection neuron axonogenesis (GO:0021952)2.72397973
57gene silencing by RNA (GO:0031047)2.70836805
58positive regulation by host of viral transcription (GO:0043923)2.70373841
59replication fork processing (GO:0031297)2.68414919
60TOR signaling (GO:0031929)2.68273236
61transcription from mitochondrial promoter (GO:0006390)2.67621740
62detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.66002203
63central nervous system neuron axonogenesis (GO:0021955)2.64588792
64phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.61476599
65histone lysine methylation (GO:0034968)2.61074548
66single strand break repair (GO:0000012)2.60170942
67cell-cell recognition (GO:0009988)2.59765913
68sensory perception of smell (GO:0007608)2.58402494
69somatic hypermutation of immunoglobulin genes (GO:0016446)2.58159306
70somatic diversification of immune receptors via somatic mutation (GO:0002566)2.58159306
71cytoplasmic mRNA processing body assembly (GO:0033962)2.57716207
72microtubule anchoring (GO:0034453)2.56692701
73histone monoubiquitination (GO:0010390)2.55465334
74regulation of cAMP-dependent protein kinase activity (GO:2000479)2.55339205
75termination of RNA polymerase I transcription (GO:0006363)2.55110323
76transcription elongation from RNA polymerase I promoter (GO:0006362)2.55071865
77peptidyl-arginine methylation (GO:0018216)2.54845129
78peptidyl-arginine N-methylation (GO:0035246)2.54845129
79protein targeting to lysosome (GO:0006622)2.54529122
80establishment of protein localization to vacuole (GO:0072666)2.54529122
81protein targeting to vacuole (GO:0006623)2.54529122
82positive regulation of skeletal muscle tissue development (GO:0048643)2.53746294
83negative regulation of dendrite development (GO:2000171)2.52652859
84meiotic chromosome segregation (GO:0045132)2.52129055
85DNA replication initiation (GO:0006270)2.50935601
86COPII vesicle coating (GO:0048208)2.50854444
87mitotic sister chromatid segregation (GO:0000070)2.50778398
88negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.50145988
89rRNA methylation (GO:0031167)2.49987065
90snRNA processing (GO:0016180)2.49015014
91neuron fate specification (GO:0048665)2.48101958
92histone methylation (GO:0016571)2.47895384
93regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.46780830
94ribosome assembly (GO:0042255)2.45975801
95viral mRNA export from host cell nucleus (GO:0046784)2.45974509
96microtubule depolymerization (GO:0007019)2.45866467
97glycosphingolipid biosynthetic process (GO:0006688)2.44313279
98regulation of DNA methylation (GO:0044030)2.43986499
99regulation of NFAT protein import into nucleus (GO:0051532)2.43700641
100positive regulation of catecholamine secretion (GO:0033605)2.43620388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.09043659
2E2F7_22180533_ChIP-Seq_HELA_Human6.54363355
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.06016741
4IGF1R_20145208_ChIP-Seq_DFB_Human3.92584809
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.65228974
6GATA1_22025678_ChIP-Seq_K562_Human2.88693291
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.73880348
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.71842551
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.62781463
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.59267125
11ZNF274_21170338_ChIP-Seq_K562_Hela2.53945349
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.50513044
13ER_23166858_ChIP-Seq_MCF-7_Human2.39042468
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36567441
15EZH2_22144423_ChIP-Seq_EOC_Human2.34573165
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04698446
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.04060844
18EWS_26573619_Chip-Seq_HEK293_Human1.99197149
19VDR_22108803_ChIP-Seq_LS180_Human1.97571200
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.95253317
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94957596
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94025088
23FUS_26573619_Chip-Seq_HEK293_Human1.88698901
24PADI4_21655091_ChIP-ChIP_MCF-7_Human1.83826124
25GBX2_23144817_ChIP-Seq_PC3_Human1.77567214
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.77131667
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75726413
28ELK1_19687146_ChIP-ChIP_HELA_Human1.74820961
29DCP1A_22483619_ChIP-Seq_HELA_Human1.74471134
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73630802
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.68424623
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68213292
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64408113
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62661505
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.61642256
36CIITA_25753668_ChIP-Seq_RAJI_Human1.53024634
37MYC_22102868_ChIP-Seq_BL_Human1.52406244
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51834386
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.48154836
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47497235
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.45792299
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.44213703
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41261125
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41106468
45FOXP3_21729870_ChIP-Seq_TREG_Human1.33660004
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32269227
47MYC_18940864_ChIP-ChIP_HL60_Human1.28362995
48PKCTHETA_26484144_Chip-Seq_BREAST_Human1.25687958
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.24505520
50STAT3_23295773_ChIP-Seq_U87_Human1.23530864
51KDM5A_27292631_Chip-Seq_BREAST_Human1.21106393
52SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19372450
53ZNF263_19887448_ChIP-Seq_K562_Human1.18672797
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17005119
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15791590
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14748436
57AHR_22903824_ChIP-Seq_MCF-7_Human1.13886545
58CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12276437
59SCL_19346495_ChIP-Seq_HPC-7_Human1.12028739
60VDR_23849224_ChIP-Seq_CD4+_Human1.10657271
61TCF4_23295773_ChIP-Seq_U87_Human1.09265976
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06242830
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.05485563
64E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04928921
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04528881
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04120946
67CBP_20019798_ChIP-Seq_JUKART_Human1.04120946
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.04056980
69SMAD4_21799915_ChIP-Seq_A2780_Human1.02844569
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01683138
71RXR_22108803_ChIP-Seq_LS180_Human1.00630427
72FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99506228
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98960291
74AR_21572438_ChIP-Seq_LNCaP_Human0.98279757
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97128195
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96825817
77ARNT_22903824_ChIP-Seq_MCF-7_Human0.96637512
78TAF15_26573619_Chip-Seq_HEK293_Human0.96602374
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95982539
80THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94610847
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94541308
82IRF1_19129219_ChIP-ChIP_H3396_Human0.93169126
83HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92315583
84PRDM14_20953172_ChIP-Seq_ESCs_Human0.91738644
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90022082
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.87552394
87RUNX2_22187159_ChIP-Seq_PCA_Human0.87525599
88ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86463268
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86174701
90CBX2_27304074_Chip-Seq_ESCs_Mouse0.84604417
91GABP_17652178_ChIP-ChIP_JURKAT_Human0.84431238
92BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83669585
93WDR5_24793694_ChIP-Seq_LNCAP_Human0.83462670
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79642977
95ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79345239
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.78573405
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.76947963
98SOX9_26525672_Chip-Seq_HEART_Mouse0.76539763
99TTF2_22483619_ChIP-Seq_HELA_Human0.76372885
100MYC_19030024_ChIP-ChIP_MESCs_Mouse0.75758547

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.14477404
2MP0009697_abnormal_copulation3.53260804
3MP0010094_abnormal_chromosome_stability2.92842485
4MP0010234_abnormal_vibrissa_follicle2.57150668
5MP0002102_abnormal_ear_morphology2.39167443
6MP0008058_abnormal_DNA_repair2.32128149
7MP0003693_abnormal_embryo_hatching2.20271333
8MP0003890_abnormal_embryonic-extraembry2.15539950
9MP0000372_irregular_coat_pigmentation2.07934053
10MP0002163_abnormal_gland_morphology2.07776845
11MP0003077_abnormal_cell_cycle1.96336253
12MP0010352_gastrointestinal_tract_polyps1.94791382
13MP0008995_early_reproductive_senescence1.92926505
14MP0001529_abnormal_vocalization1.80274019
15MP0004233_abnormal_muscle_weight1.75314318
16MP0004084_abnormal_cardiac_muscle1.71107987
17MP0005394_taste/olfaction_phenotype1.70686199
18MP0005499_abnormal_olfactory_system1.70686199
19MP0000678_abnormal_parathyroid_gland1.65720781
20MP0003111_abnormal_nucleus_morphology1.63506152
21MP0001661_extended_life_span1.63086992
22MP0008789_abnormal_olfactory_epithelium1.62704130
23MP0008877_abnormal_DNA_methylation1.56852256
24MP0004134_abnormal_chest_morphology1.55743163
25MP0005379_endocrine/exocrine_gland_phen1.53722403
26MP0004808_abnormal_hematopoietic_stem1.50020905
27MP0003959_abnormal_lean_body1.45060680
28MP0002160_abnormal_reproductive_system1.42545627
29MP0003935_abnormal_craniofacial_develop1.42075935
30MP0001348_abnormal_lacrimal_gland1.37763495
31MP0003718_maternal_effect1.36726093
32MP0003950_abnormal_plasma_membrane1.35072489
33MP0005645_abnormal_hypothalamus_physiol1.34606077
34MP0001270_distended_abdomen1.29674414
35MP0003385_abnormal_body_wall1.29428661
36MP0005220_abnormal_exocrine_pancreas1.28680396
37MP0000749_muscle_degeneration1.23733909
38MP0001730_embryonic_growth_arrest1.23579867
39MP0002009_preneoplasia1.22379686
40MP0002184_abnormal_innervation1.21561825
41MP0002751_abnormal_autonomic_nervous1.21363056
42MP0001764_abnormal_homeostasis1.20266948
43MP0003656_abnormal_erythrocyte_physiolo1.16068490
44MP0002132_abnormal_respiratory_system1.15716279
45MP0003763_abnormal_thymus_physiology1.14853984
46MP0004197_abnormal_fetal_growth/weight/1.12490888
47MP0001502_abnormal_circadian_rhythm1.11025855
48MP0010678_abnormal_skin_adnexa1.08567771
49MP0002108_abnormal_muscle_morphology1.07952940
50MP0003755_abnormal_palate_morphology1.07620518
51MP0002127_abnormal_cardiovascular_syste1.04908970
52MP0001929_abnormal_gametogenesis1.04696114
53MP0001697_abnormal_embryo_size1.03300243
54MP0003221_abnormal_cardiomyocyte_apopto1.01328426
55MP0003984_embryonic_growth_retardation0.99224801
56MP0001944_abnormal_pancreas_morphology0.98807286
57MP0000350_abnormal_cell_proliferation0.98655421
58MP0002088_abnormal_embryonic_growth/wei0.96290332
59MP0008007_abnormal_cellular_replicative0.95941064
60MP0004264_abnormal_extraembryonic_tissu0.95799285
61MP0002269_muscular_atrophy0.94139534
62MP0002735_abnormal_chemical_nociception0.94067591
63MP0005380_embryogenesis_phenotype0.93037078
64MP0001672_abnormal_embryogenesis/_devel0.93037078
65MP0005266_abnormal_metabolism0.91286959
66MP0002332_abnormal_exercise_endurance0.89273531
67MP0003937_abnormal_limbs/digits/tail_de0.88096910
68MP0002233_abnormal_nose_morphology0.87775025
69MP0003698_abnormal_male_reproductive0.87547846
70MP0000013_abnormal_adipose_tissue0.87014224
71MP0003195_calcinosis0.86983058
72MP0005646_abnormal_pituitary_gland0.86187341
73MP0003942_abnormal_urinary_system0.86086914
74MP0000759_abnormal_skeletal_muscle0.84908155
75MP0006035_abnormal_mitochondrial_morpho0.82609788
76MP0000681_abnormal_thyroid_gland0.81790088
77MP0001346_abnormal_lacrimal_gland0.80969463
78MP0002210_abnormal_sex_determination0.80104535
79MP0002928_abnormal_bile_duct0.79877368
80MP0002638_abnormal_pupillary_reflex0.79657509
81MP0003786_premature_aging0.77822389
82MP0008775_abnormal_heart_ventricle0.76750135
83MP0000049_abnormal_middle_ear0.76516801
84MP0009780_abnormal_chondrocyte_physiolo0.76390812
85MP0000003_abnormal_adipose_tissue0.76328751
86MP0001984_abnormal_olfaction0.75853419
87MP0003699_abnormal_female_reproductive0.74544431
88MP0002837_dystrophic_cardiac_calcinosis0.74505119
89MP0001286_abnormal_eye_development0.73688924
90MP0005409_darkened_coat_color0.72809462
91MP0003115_abnormal_respiratory_system0.72621691
92MP0004036_abnormal_muscle_relaxation0.72059736
93MP0002086_abnormal_extraembryonic_tissu0.71706656
94MP0005647_abnormal_sex_gland0.71190113
95MP0003943_abnormal_hepatobiliary_system0.69391355
96MP0004381_abnormal_hair_follicle0.69289748
97MP0001664_abnormal_digestion0.68863748
98MP0002080_prenatal_lethality0.68734918
99MP0000428_abnormal_craniofacial_morphol0.68720940
100MP0009115_abnormal_fat_cell0.68022118

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.74187431
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.53417040
3Asymmetry of the thorax (HP:0001555)3.33277457
4Facial hemangioma (HP:0000329)3.19948596
5Long clavicles (HP:0000890)3.10730902
6Cutaneous melanoma (HP:0012056)3.10062710
7Squamous cell carcinoma (HP:0002860)2.96832815
8High anterior hairline (HP:0009890)2.94931754
9Aplasia/Hypoplasia of the uvula (HP:0010293)2.91257301
10Meningioma (HP:0002858)2.89773286
11Heterotopia (HP:0002282)2.77810700
12Medulloblastoma (HP:0002885)2.77542386
13Type 2 muscle fiber atrophy (HP:0003554)2.72197772
14Abnormality of the columella (HP:0009929)2.66380961
15Depressed nasal tip (HP:0000437)2.66276454
16Cystic hygroma (HP:0000476)2.64879259
17Nephroblastoma (Wilms tumor) (HP:0002667)2.64340792
18Self-mutilation (HP:0000742)2.61984037
19Basal cell carcinoma (HP:0002671)2.50485138
20Abnormality of DNA repair (HP:0003254)2.46882715
21Thyroid carcinoma (HP:0002890)2.45840340
22Poikiloderma (HP:0001029)2.43705252
23Embryonal renal neoplasm (HP:0011794)2.42930330
24Volvulus (HP:0002580)2.40245602
25Fatigable weakness (HP:0003473)2.37485998
26Abnormality of the neuromuscular junction (HP:0003398)2.37485998
27Abnormality of the preputium (HP:0100587)2.35143038
28Abnormality of chromosome stability (HP:0003220)2.34298214
29Muscle fiber atrophy (HP:0100295)2.28370953
30Dry hair (HP:0011359)2.27649523
31Neoplasm of the adrenal cortex (HP:0100641)2.21921805
32Curly hair (HP:0002212)2.21281911
33Papillary thyroid carcinoma (HP:0002895)2.19622506
34Cerebellar dysplasia (HP:0007033)2.18698838
35Abnormality of the ileum (HP:0001549)2.15054700
36Meckel diverticulum (HP:0002245)2.14930237
37Sloping forehead (HP:0000340)2.10215192
38Proximal tubulopathy (HP:0000114)2.09817496
39Cafe-au-lait spot (HP:0000957)2.09305699
40Bony spicule pigmentary retinopathy (HP:0007737)2.09111531
41Hypoplastic iliac wings (HP:0002866)2.06606757
42Truncal obesity (HP:0001956)2.06445853
43Short chin (HP:0000331)2.04020941
44Arteriovenous malformation (HP:0100026)2.03811988
45Poor eye contact (HP:0000817)2.01785652
46Small intestinal stenosis (HP:0012848)2.01544277
47Duodenal stenosis (HP:0100867)2.01544277
48Weak cry (HP:0001612)2.01175254
49Capillary hemangiomas (HP:0005306)2.00864429
50Skin tags (HP:0010609)2.00453058
51Adenoma sebaceum (HP:0009720)1.98540356
52Angiofibromas (HP:0010615)1.98540356
53Macroorchidism (HP:0000053)1.97964522
54Reduced antithrombin III activity (HP:0001976)1.97867938
55Popliteal pterygium (HP:0009756)1.96309135
56Benign neoplasm of the central nervous system (HP:0100835)1.95930269
57Aplasia/Hypoplasia of the nipples (HP:0006709)1.94058946
58Breast carcinoma (HP:0003002)1.93612524
59Dyschromatopsia (HP:0007641)1.93563139
60Abnormality of the carotid arteries (HP:0005344)1.88277031
61Intestinal atresia (HP:0011100)1.87933033
62Easy fatigability (HP:0003388)1.84430730
63Neoplasm of the thyroid gland (HP:0100031)1.82522366
64Abnormality of the duodenum (HP:0002246)1.81722153
65Large earlobe (HP:0009748)1.81434472
66Barrel-shaped chest (HP:0001552)1.79121169
67Embryonal neoplasm (HP:0002898)1.77584460
68Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74504741
69Intellectual disability, profound (HP:0002187)1.73377395
70Preauricular skin tag (HP:0000384)1.72761261
71Relative macrocephaly (HP:0004482)1.72664014
72Hypoplastic pelvis (HP:0008839)1.72587200
73Deep palmar crease (HP:0006191)1.71764681
74Urinary urgency (HP:0000012)1.70655182
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69654750
76Abnormal protein N-linked glycosylation (HP:0012347)1.69654750
77Abnormal protein glycosylation (HP:0012346)1.69654750
78Abnormal glycosylation (HP:0012345)1.69654750
79Lissencephaly (HP:0001339)1.69043254
80Thoracic kyphosis (HP:0002942)1.68224845
81Aqueductal stenosis (HP:0002410)1.68095652
82Anhidrosis (HP:0000970)1.67917771
83Myelodysplasia (HP:0002863)1.66671485
84Protruding tongue (HP:0010808)1.65909672
85Sparse lateral eyebrow (HP:0005338)1.64895057
86Microtia (HP:0008551)1.64704156
87Cutis marmorata (HP:0000965)1.63767014
88Open mouth (HP:0000194)1.63628677
89Unilateral renal agenesis (HP:0000122)1.62961131
90Partial agenesis of the corpus callosum (HP:0001338)1.62351186
91Broad palm (HP:0001169)1.62281742
92Abnormal pancreas size (HP:0012094)1.62082548
93Neoplasm of the oral cavity (HP:0100649)1.61826989
94Insidious onset (HP:0003587)1.61773842
95Termporal pattern (HP:0011008)1.61773842
96Conjunctival hamartoma (HP:0100780)1.60535382
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.58384508
98Blepharophimosis (HP:0000581)1.57188501
99Attenuation of retinal blood vessels (HP:0007843)1.57186900
100Abnormality of lateral ventricle (HP:0030047)1.56314266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K95.45182986
2PINK14.61334442
3FRK3.42945660
4EIF2AK32.50367615
5BRD42.44127392
6MAP3K102.38895594
7LATS12.37480946
8MUSK2.21428125
9PBK2.21391709
10ICK2.16642328
11CDK82.09891566
12MARK12.07644285
13BMPR1B2.05275745
14MAP2K72.01433700
15MARK31.96802859
16MAP3K61.83680320
17PIK3CG1.81830433
18WNK31.80808014
19PRKG21.80098061
20EEF2K1.65632110
21CCNB11.61555254
22NEK21.61180897
23CDK121.54986801
24SIK11.42736016
25CHEK21.31642304
26PKN21.31568318
27EIF2AK11.28919295
28MAP3K41.26535495
29DYRK31.18982546
30PRPF4B1.17569882
31FGFR21.17466701
32BCR1.17423741
33RPS6KB11.07499445
34TRIM281.06104013
35PASK1.04756669
36FGFR31.03167776
37CDK70.97172656
38NEK10.96930641
39ZAK0.96152776
40RPS6KA40.92693631
41RPS6KB20.90902266
42IRAK20.89871969
43STK30.89768652
44ERBB30.89042953
45ATM0.84052826
46TRPM70.78331204
47CLK10.77677970
48CDK30.75974145
49BRSK20.73960573
50SIK20.72530147
51PNCK0.72107249
52AKT30.70907061
53MAP3K130.69404072
54SMG10.69122868
55CAMK1G0.67904996
56MAPK130.66661262
57TAOK30.65359071
58WEE10.65185320
59SRPK10.63618898
60CHEK10.63197965
61IRAK10.62752779
62RET0.60650881
63IRAK40.60064355
64CDK90.60011926
65SIK30.59492529
66CSNK1A1L0.58958455
67AURKB0.58571074
68MAP2K40.57749571
69NME20.56550376
70PRKAA10.56244237
71AURKA0.53142012
72RPS6KA50.52385643
73ARAF0.52376488
74PRKCQ0.51941877
75ATR0.48957590
76SGK20.48919607
77PLK10.46976024
78NEK90.46524055
79OBSCN0.45336577
80CSNK1G30.44630213
81CDK10.44380013
82TAF10.43753681
83SCYL20.42838658
84SGK30.41015138
85MELK0.40322725
86CSNK1G10.39557978
87RAF10.39209379
88KSR20.38194279
89MAPK110.38144405
90PRKCE0.38139832
91CASK0.37387126
92CSNK1D0.37124231
93NUAK10.35902450
94CDK20.35502299
95EIF2AK20.31303599
96MAP3K50.31147113
97MTOR0.30993233
98PLK30.30734466
99CAMK1D0.29936171
100CDC70.29383318

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004502.65559125
2Basal transcription factors_Homo sapiens_hsa030222.51753928
3Fanconi anemia pathway_Homo sapiens_hsa034602.42579880
4Olfactory transduction_Homo sapiens_hsa047402.37744527
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20312085
6Taste transduction_Homo sapiens_hsa047421.94086030
7Alcoholism_Homo sapiens_hsa050341.89265170
8RNA transport_Homo sapiens_hsa030131.79207229
9Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.76535793
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76501590
11Cell cycle_Homo sapiens_hsa041101.76321435
12Endometrial cancer_Homo sapiens_hsa052131.70918827
13One carbon pool by folate_Homo sapiens_hsa006701.69910642
14Non-small cell lung cancer_Homo sapiens_hsa052231.68638022
15Gap junction_Homo sapiens_hsa045401.67709093
16Non-homologous end-joining_Homo sapiens_hsa034501.61006015
17mTOR signaling pathway_Homo sapiens_hsa041501.54411160
18mRNA surveillance pathway_Homo sapiens_hsa030151.48745685
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.43590544
20Thyroid cancer_Homo sapiens_hsa052161.40739192
21Glioma_Homo sapiens_hsa052141.31751251
22B cell receptor signaling pathway_Homo sapiens_hsa046621.27537336
23Nucleotide excision repair_Homo sapiens_hsa034201.27462459
24Prostate cancer_Homo sapiens_hsa052151.27266163
25Oocyte meiosis_Homo sapiens_hsa041141.26089681
26Homologous recombination_Homo sapiens_hsa034401.24348948
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22181880
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21168339
29Melanoma_Homo sapiens_hsa052181.15685705
30Systemic lupus erythematosus_Homo sapiens_hsa053221.15589666
31Chronic myeloid leukemia_Homo sapiens_hsa052201.14620352
32Viral carcinogenesis_Homo sapiens_hsa052031.14038081
33Long-term depression_Homo sapiens_hsa047301.13858476
34Butanoate metabolism_Homo sapiens_hsa006501.12049094
35Inositol phosphate metabolism_Homo sapiens_hsa005621.11708505
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11203865
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07310169
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06508303
39FoxO signaling pathway_Homo sapiens_hsa040681.04744602
40N-Glycan biosynthesis_Homo sapiens_hsa005101.04664266
41Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02455295
42DNA replication_Homo sapiens_hsa030301.02269850
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.02154895
44Acute myeloid leukemia_Homo sapiens_hsa052211.01993953
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01914265
46MicroRNAs in cancer_Homo sapiens_hsa052061.01888865
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01383596
48AMPK signaling pathway_Homo sapiens_hsa041520.98387822
49Spliceosome_Homo sapiens_hsa030400.97073767
50ErbB signaling pathway_Homo sapiens_hsa040120.95381115
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95024450
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93210285
53p53 signaling pathway_Homo sapiens_hsa041150.90273051
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89555306
55Hepatitis B_Homo sapiens_hsa051610.89407461
56Phototransduction_Homo sapiens_hsa047440.88148536
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.88104691
58Circadian rhythm_Homo sapiens_hsa047100.87397598
59Pyrimidine metabolism_Homo sapiens_hsa002400.87299779
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84443641
61Oxytocin signaling pathway_Homo sapiens_hsa049210.82318912
62Colorectal cancer_Homo sapiens_hsa052100.81992714
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79604177
64Pancreatic cancer_Homo sapiens_hsa052120.79496521
65Small cell lung cancer_Homo sapiens_hsa052220.79227403
66RNA polymerase_Homo sapiens_hsa030200.78390294
67Circadian entrainment_Homo sapiens_hsa047130.77599172
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.75719303
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75307706
70Hedgehog signaling pathway_Homo sapiens_hsa043400.74814054
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74374377
72Insulin signaling pathway_Homo sapiens_hsa049100.74263383
73Glucagon signaling pathway_Homo sapiens_hsa049220.73547633
74Choline metabolism in cancer_Homo sapiens_hsa052310.72876464
75Insulin resistance_Homo sapiens_hsa049310.72065302
76Nicotine addiction_Homo sapiens_hsa050330.71518493
77Dopaminergic synapse_Homo sapiens_hsa047280.70880373
78Sphingolipid metabolism_Homo sapiens_hsa006000.68407506
79Estrogen signaling pathway_Homo sapiens_hsa049150.66400815
80Cholinergic synapse_Homo sapiens_hsa047250.64838704
81RNA degradation_Homo sapiens_hsa030180.63625125
82Amphetamine addiction_Homo sapiens_hsa050310.62889989
83Type II diabetes mellitus_Homo sapiens_hsa049300.62618695
84T cell receptor signaling pathway_Homo sapiens_hsa046600.62533537
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61292165
86Prolactin signaling pathway_Homo sapiens_hsa049170.61104510
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60722114
88Steroid biosynthesis_Homo sapiens_hsa001000.60691877
89Long-term potentiation_Homo sapiens_hsa047200.60523488
90TGF-beta signaling pathway_Homo sapiens_hsa043500.57721484
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56748959
92Purine metabolism_Homo sapiens_hsa002300.55999650
93Renal cell carcinoma_Homo sapiens_hsa052110.54523029
94Cocaine addiction_Homo sapiens_hsa050300.53633763
95Ovarian steroidogenesis_Homo sapiens_hsa049130.52137853
96ABC transporters_Homo sapiens_hsa020100.51522089
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49401597
98Mismatch repair_Homo sapiens_hsa034300.49009499
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.48550804
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48239570

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