BEND3P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of NFAT protein import into nucleus (GO:0051532)3.87812045
2focal adhesion assembly (GO:0048041)3.83431760
3cell-substrate adherens junction assembly (GO:0007045)3.83431760
4nuclear pore complex assembly (GO:0051292)3.80890874
5histone H3-K36 demethylation (GO:0070544)3.74936942
6barbed-end actin filament capping (GO:0051016)3.71915616
7cytoplasmic mRNA processing body assembly (GO:0033962)3.68330514
83-UTR-mediated mRNA stabilization (GO:0070935)3.65552858
9adherens junction assembly (GO:0034333)3.52933937
10regulation of oxidative stress-induced neuron death (GO:1903203)3.44899244
11nuclear pore organization (GO:0006999)3.44371294
12cell-substrate junction assembly (GO:0007044)3.38898463
13stress granule assembly (GO:0034063)3.29974480
14negative regulation of erythrocyte differentiation (GO:0045647)3.26555135
15negative regulation of cell size (GO:0045792)3.05720749
16protein localization to endosome (GO:0036010)3.05494244
17positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.03435846
18regulation of RNA export from nucleus (GO:0046831)3.01317839
19response to muscle activity (GO:0014850)2.96333914
20cortical actin cytoskeleton organization (GO:0030866)2.95114163
21regulation of nucleobase-containing compound transport (GO:0032239)2.91861083
22cytoskeletal anchoring at plasma membrane (GO:0007016)2.87308221
23cellular response to osmotic stress (GO:0071470)2.87212254
24embryonic process involved in female pregnancy (GO:0060136)2.85900181
25regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.84430186
26regulation of ARF GTPase activity (GO:0032312)2.82650239
27histone lysine demethylation (GO:0070076)2.78936664
28Golgi transport vesicle coating (GO:0048200)2.78215590
29COPI coating of Golgi vesicle (GO:0048205)2.78215590
30myofibril assembly (GO:0030239)2.77270446
31negative regulation of necroptotic process (GO:0060546)2.73473094
32insulin-like growth factor receptor signaling pathway (GO:0048009)2.72460231
33peptidyl-threonine modification (GO:0018210)2.71373893
34histone demethylation (GO:0016577)2.70238844
35pore complex assembly (GO:0046931)2.70122253
36positive regulation of blood vessel endothelial cell migration (GO:0043536)2.69569640
37regulation of histone H3-K27 methylation (GO:0061085)2.68849621
38apoptotic process involved in morphogenesis (GO:0060561)2.68806886
39TOR signaling (GO:0031929)2.68701631
40muscle cell cellular homeostasis (GO:0046716)2.68141508
41fibroblast migration (GO:0010761)2.63604072
42mannose metabolic process (GO:0006013)2.63220982
43negative regulation of fatty acid transport (GO:2000192)2.61482155
44Notch signaling involved in heart development (GO:0061314)2.60439453
45dosage compensation (GO:0007549)2.59189849
46COPII vesicle coating (GO:0048208)2.56566422
47response to muramyl dipeptide (GO:0032495)2.55373069
48peptidyl-threonine phosphorylation (GO:0018107)2.54550808
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.53325813
50morphogenesis of an epithelial sheet (GO:0002011)2.50732033
51stress fiber assembly (GO:0043149)2.50333446
52response to laminar fluid shear stress (GO:0034616)2.50305617
53retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.48926788
54cortical cytoskeleton organization (GO:0030865)2.48545392
55peptidyl-lysine dimethylation (GO:0018027)2.48523511
56regulation of myoblast differentiation (GO:0045661)2.47072589
57maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.43483196
58spliceosomal tri-snRNP complex assembly (GO:0000244)2.42162809
59protein dealkylation (GO:0008214)2.41990130
60protein demethylation (GO:0006482)2.41990130
61sarcomere organization (GO:0045214)2.39726778
62activation of Rac GTPase activity (GO:0032863)2.37700156
63RNA stabilization (GO:0043489)2.37270939
64mRNA stabilization (GO:0048255)2.37270939
65positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.36694553
66cardiac muscle cell proliferation (GO:0060038)2.34959470
67negative regulation of homotypic cell-cell adhesion (GO:0034111)2.34896002
68regulation of skeletal muscle fiber development (GO:0048742)2.34861256
69skin morphogenesis (GO:0043589)2.33222376
70protein targeting to plasma membrane (GO:0072661)2.33050802
71peptidyl-arginine N-methylation (GO:0035246)2.32165015
72peptidyl-arginine methylation (GO:0018216)2.32165015
73cellular response to fluid shear stress (GO:0071498)2.31497211
74regulation of necroptotic process (GO:0060544)2.30645289
75regulation of transforming growth factor beta2 production (GO:0032909)2.29892751
76hemidesmosome assembly (GO:0031581)2.29079914
77regulation of translational fidelity (GO:0006450)2.28226798
78intracellular estrogen receptor signaling pathway (GO:0030520)2.26284862
79negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.23927064
80hypotonic response (GO:0006971)2.23484004
81positive regulation of myotube differentiation (GO:0010831)2.22682778
82epithelial cell differentiation involved in prostate gland development (GO:0060742)2.22261127
83protein retention in ER lumen (GO:0006621)2.19938330
84embryonic eye morphogenesis (GO:0048048)2.19717196
85regulation of DNA damage checkpoint (GO:2000001)2.19136162
86negative regulation of myotube differentiation (GO:0010832)2.18860025
87phosphatidylinositol dephosphorylation (GO:0046856)2.17618826
88histone H4 deacetylation (GO:0070933)2.17328708
89definitive hemopoiesis (GO:0060216)2.16767882
90peptidyl-serine phosphorylation (GO:0018105)2.16209382
91chondroitin sulfate biosynthetic process (GO:0030206)2.16175388
92regulation of myotube differentiation (GO:0010830)2.15635836
93histone H3-K9 demethylation (GO:0033169)2.15279855
94regulation of cell size (GO:0008361)2.12232230
95germinal center formation (GO:0002467)2.11666903
96peptidyl-serine modification (GO:0018209)2.10987964
97positive regulation of receptor recycling (GO:0001921)2.10926147
98negative regulation of microtubule polymerization (GO:0031115)2.10467319
99positive regulation of catecholamine secretion (GO:0033605)2.09816855
100activation of MAPKKK activity (GO:0000185)2.09427448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.04116244
2MYC_22102868_ChIP-Seq_BL_Human3.32865093
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.98406790
4KDM2B_26808549_Chip-Seq_SUP-B15_Human2.87962562
5KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.87329817
6KDM2B_26808549_Chip-Seq_DND41_Human2.80676290
7VDR_21846776_ChIP-Seq_THP-1_Human2.63534018
8ZNF263_19887448_ChIP-Seq_K562_Human2.58270283
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.48663266
10TCF7_22412390_ChIP-Seq_EML_Mouse2.41475572
11CLOCK_20551151_ChIP-Seq_293T_Human2.41458189
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.39995113
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.39771496
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.36311514
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.32086674
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.17429203
17KDM2B_26808549_Chip-Seq_K562_Human2.16336759
18P300_27058665_Chip-Seq_ZR-75-30cells_Human2.05557139
19KDM2B_26808549_Chip-Seq_JURKAT_Human2.04725252
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.02663456
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02252329
22CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.94676532
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.88755410
24GATA1_22025678_ChIP-Seq_K562_Human1.85043271
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.80068270
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.77839594
27DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.76972044
28LXR_22292898_ChIP-Seq_THP-1_Human1.72193411
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70881411
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.70225218
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70140369
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68930457
33RACK7_27058665_Chip-Seq_MCF-7_Human1.68081867
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65554342
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63632215
36VDR_24763502_ChIP-Seq_THP-1_Human1.63528269
37TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.59633744
38TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58407011
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.58140350
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.57330986
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.55766219
42UBF1/2_26484160_Chip-Seq_HMECs_Human1.53402495
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51108541
44E2F7_22180533_ChIP-Seq_HELA_Human1.49713800
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48743437
46MAF_26560356_Chip-Seq_TH1_Human1.47095291
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46304900
48TP53_22127205_ChIP-Seq_IMR90_Human1.45563222
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44014680
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44014680
51ATF3_27146783_Chip-Seq_COLON_Human1.43519525
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43107372
53CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.42527887
54EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39837000
55TBX20_22080862_ChIP-Seq_HEART_Mouse1.39416059
56TBX20_22328084_ChIP-Seq_HEART_Mouse1.39416059
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36101507
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34673801
59ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33664908
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33626038
61UTX_26944678_Chip-Seq_JUKART_Human1.33586996
62MAF_26560356_Chip-Seq_TH2_Human1.33458010
63PKCTHETA_26484144_Chip-Seq_BREAST_Human1.33064347
64CHD1_26751641_Chip-Seq_LNCaP_Human1.29865727
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29589953
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.28673191
67SPI1_23127762_ChIP-Seq_K562_Human1.28625727
68GATA1_19941826_ChIP-Seq_K562_Human1.27544043
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.27191912
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.26538206
71NCOR1_26117541_ChIP-Seq_K562_Human1.25911749
72CREB1_26743006_Chip-Seq_LNCaP_Human1.25566546
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.25532198
74NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25001849
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18347199
76NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17778524
77CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15533494
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15317666
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15202065
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14826603
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13358880
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13221835
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12499393
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12008380
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11659567
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11552448
87FOXM1_23109430_ChIP-Seq_U2OS_Human1.10383475
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09880969
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08126902
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.07854223
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06870559
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04317772
93MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03421729
94CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01216305
95SCL_19346495_ChIP-Seq_HPC-7_Human1.01140744
96MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99345137
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99341266
98SMC4_20622854_ChIP-Seq_HELA_Human0.99187573
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.98739716
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97798818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.11089984
2MP0008438_abnormal_cutaneous_collagen3.07221782
3MP0000749_muscle_degeneration2.94170449
4MP0005076_abnormal_cell_differentiation2.82570221
5MP0001849_ear_inflammation2.78028094
6MP0005451_abnormal_body_composition2.71326666
7MP0010234_abnormal_vibrissa_follicle2.66428078
8MP0004233_abnormal_muscle_weight2.61810302
9MP0009697_abnormal_copulation2.31943936
10MP0004272_abnormal_basement_membrane2.28208109
11MP0000751_myopathy2.24647614
12MP0003091_abnormal_cell_migration2.22131648
13MP0004084_abnormal_cardiac_muscle2.16319576
14MP0003566_abnormal_cell_adhesion2.14656396
15MP0005623_abnormal_meninges_morphology2.13286548
16MP0000759_abnormal_skeletal_muscle2.09957756
17MP0003656_abnormal_erythrocyte_physiolo2.02083035
18MP0010352_gastrointestinal_tract_polyps1.99467406
19MP0002877_abnormal_melanocyte_morpholog1.99313764
20MP0000733_abnormal_muscle_development1.92218728
21MP0002269_muscular_atrophy1.84851985
22MP0004087_abnormal_muscle_fiber1.79159968
23MP0003828_pulmonary_edema1.75542103
24MP0002108_abnormal_muscle_morphology1.71618200
25MP0000537_abnormal_urethra_morphology1.69822280
26MP0010368_abnormal_lymphatic_system1.69387816
27MP0005409_darkened_coat_color1.63074085
28MP0003300_gastrointestinal_ulcer1.62296740
29MP0004036_abnormal_muscle_relaxation1.61370835
30MP0002009_preneoplasia1.57522027
31MP0003763_abnormal_thymus_physiology1.53418490
32MP0003221_abnormal_cardiomyocyte_apopto1.53015378
33MP0000747_muscle_weakness1.52985097
34MP0001661_extended_life_span1.45477472
35MP0010630_abnormal_cardiac_muscle1.45428942
36MP0005275_abnormal_skin_tensile1.44860254
37MP0004808_abnormal_hematopoietic_stem1.40373655
38MP0008260_abnormal_autophagy1.32777897
39MP0003385_abnormal_body_wall1.27566728
40MP0002249_abnormal_larynx_morphology1.27496311
41MP0004185_abnormal_adipocyte_glucose1.25677394
42MP0005503_abnormal_tendon_morphology1.24351426
43MP0003315_abnormal_perineum_morphology1.20727061
44MP0005621_abnormal_cell_physiology1.20291585
45MP0001958_emphysema1.14165274
46MP0006138_congestive_heart_failure1.08004940
47MP0005257_abnormal_intraocular_pressure1.07030542
48MP0002332_abnormal_exercise_endurance1.03677665
49MP0000750_abnormal_muscle_regeneration1.03474118
50MP0000003_abnormal_adipose_tissue1.01894641
51MP0003453_abnormal_keratinocyte_physiol1.01328823
52MP0000767_abnormal_smooth_muscle1.01041074
53MP0005369_muscle_phenotype1.00357129
54MP0001348_abnormal_lacrimal_gland0.96991166
55MP0000858_altered_metastatic_potential0.95549651
56MP0003279_aneurysm0.94788166
57MP0002060_abnormal_skin_morphology0.94736593
58MP0003115_abnormal_respiratory_system0.92946162
59MP0000013_abnormal_adipose_tissue0.92886760
60MP0005330_cardiomyopathy0.91689514
61MP0005058_abnormal_lysosome_morphology0.91270055
62MP0004197_abnormal_fetal_growth/weight/0.90955124
63MP0001730_embryonic_growth_arrest0.90685447
64MP0000678_abnormal_parathyroid_gland0.90539939
65MP0002114_abnormal_axial_skeleton0.89096927
66MP0002106_abnormal_muscle_physiology0.88598783
67MP0003935_abnormal_craniofacial_develop0.85074507
68MP0002396_abnormal_hematopoietic_system0.84914985
69MP0002086_abnormal_extraembryonic_tissu0.84279116
70MP0002127_abnormal_cardiovascular_syste0.83893487
71MP0001299_abnormal_eye_distance/0.83713955
72MP0004947_skin_inflammation0.83273956
73MP0004859_abnormal_synaptic_plasticity0.82245443
74MP0005248_abnormal_Harderian_gland0.82199146
75MP0005620_abnormal_muscle_contractility0.81848854
76MP0004381_abnormal_hair_follicle0.81307243
77MP0005501_abnormal_skin_physiology0.81184680
78MP0003172_abnormal_lysosome_physiology0.81072705
79MP0004134_abnormal_chest_morphology0.80528300
80MP0003984_embryonic_growth_retardation0.80197548
81MP0004782_abnormal_surfactant_physiolog0.79491570
82MP0004858_abnormal_nervous_system0.79159441
83MP0002088_abnormal_embryonic_growth/wei0.77495234
84MP0005187_abnormal_penis_morphology0.75879030
85MP0000762_abnormal_tongue_morphology0.75753296
86MP0001270_distended_abdomen0.74907198
87MP0005384_cellular_phenotype0.74598696
88MP0001915_intracranial_hemorrhage0.74276008
89MP0000703_abnormal_thymus_morphology0.74263902
90MP0004130_abnormal_muscle_cell0.73161019
91MP0002796_impaired_skin_barrier0.72188559
92MP0009278_abnormal_bone_marrow0.71638120
93MP0009250_abnormal_appendicular_skeleto0.71291837
94MP0001340_abnormal_eyelid_morphology0.70381833
95MP0000350_abnormal_cell_proliferation0.70025518
96MP0009780_abnormal_chondrocyte_physiolo0.69679453
97MP0001672_abnormal_embryogenesis/_devel0.69512001
98MP0005380_embryogenesis_phenotype0.69512001
99MP0004510_myositis0.69215037
100MP0004264_abnormal_extraembryonic_tissu0.68858846

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)3.45469872
2Increased variability in muscle fiber diameter (HP:0003557)3.41784173
3Centrally nucleated skeletal muscle fibers (HP:0003687)3.40927985
4Aortic aneurysm (HP:0004942)3.23541008
5Spinal rigidity (HP:0003306)3.12258169
6Abnormality of skeletal muscle fiber size (HP:0012084)3.03791783
7Hyporeflexia of lower limbs (HP:0002600)2.99484325
8Protrusio acetabuli (HP:0003179)2.95641948
9Premature rupture of membranes (HP:0001788)2.92825760
10Scapular winging (HP:0003691)2.92706400
11Asymmetry of the thorax (HP:0001555)2.87631383
12Ulnar bowing (HP:0003031)2.81589091
13Increased connective tissue (HP:0009025)2.81163533
14Abnormality of the columella (HP:0009929)2.78805303
15Hyperacusis (HP:0010780)2.67142092
16Syringomyelia (HP:0003396)2.64702505
17Spinal cord lesions (HP:0100561)2.64702505
18Type 1 muscle fiber predominance (HP:0003803)2.59083012
19Difficulty running (HP:0009046)2.55466454
20Cerebral aneurysm (HP:0004944)2.49869976
21Distal lower limb amyotrophy (HP:0008944)2.40961333
22Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.40132056
23Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.27273261
24Arterial tortuosity (HP:0005116)2.26790730
25Muscle fiber inclusion bodies (HP:0100299)2.26714168
26EMG: myopathic abnormalities (HP:0003458)2.26415605
27Dysmetric saccades (HP:0000641)2.23408751
28Difficulty climbing stairs (HP:0003551)2.22248042
29Abnormality of the shoulder girdle musculature (HP:0001435)2.21382892
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19589110
31Vascular tortuosity (HP:0004948)2.19255560
32Genu recurvatum (HP:0002816)2.10312674
33Abnormality of the left ventricular outflow tract (HP:0011103)2.07832369
34Subaortic stenosis (HP:0001682)2.07832369
35High anterior hairline (HP:0009890)2.06738106
36Atrophic scars (HP:0001075)2.06128984
37Aortic dissection (HP:0002647)2.04831364
38Thoracic kyphosis (HP:0002942)1.98045240
39Broad face (HP:0000283)1.96762960
40Aneurysm (HP:0002617)1.96733210
41Exercise-induced muscle cramps (HP:0003710)1.95723780
42Bladder diverticulum (HP:0000015)1.94993232
43Myopathic facies (HP:0002058)1.94658845
44Abnormality of the thoracic spine (HP:0100711)1.93317195
45Ankyloglossia (HP:0010296)1.92530687
46Mitral valve prolapse (HP:0001634)1.92385730
47Pelvic girdle muscle weakness (HP:0003749)1.90213193
48Elbow flexion contracture (HP:0002987)1.90065046
49Rimmed vacuoles (HP:0003805)1.89620629
50Lower limb amyotrophy (HP:0007210)1.89566275
51Disproportionate tall stature (HP:0001519)1.89463820
52Wormian bones (HP:0002645)1.89158871
53Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.88955256
54Aortic regurgitation (HP:0001659)1.88599258
55Foot dorsiflexor weakness (HP:0009027)1.86451444
56Insomnia (HP:0100785)1.86129251
57Dilatation of the ascending aorta (HP:0005111)1.85122716
58Resting tremor (HP:0002322)1.85064560
59Heterotopia (HP:0002282)1.84117538
60Abnormality of the calcaneus (HP:0008364)1.81854643
61Neck muscle weakness (HP:0000467)1.81841657
62Thin bony cortex (HP:0002753)1.80608296
63Abnormality of the calf musculature (HP:0001430)1.78601729
64Abnormality of oral frenula (HP:0000190)1.78564741
65Shallow orbits (HP:0000586)1.78084332
66Self-mutilation (HP:0000742)1.77853681
67Nemaline bodies (HP:0003798)1.77710014
68Mildly elevated creatine phosphokinase (HP:0008180)1.77148059
69Dislocated radial head (HP:0003083)1.76960601
70Long eyelashes (HP:0000527)1.76649156
71Relative macrocephaly (HP:0004482)1.75035623
72Hammertoe (HP:0001765)1.72912222
73Abnormality of the foot musculature (HP:0001436)1.72553880
74Abnormality of the musculature of the pelvis (HP:0001469)1.71698693
75Abnormality of the hip-girdle musculature (HP:0001445)1.71698693
76Obstructive sleep apnea (HP:0002870)1.70743567
77Thin ribs (HP:0000883)1.69931432
78Steppage gait (HP:0003376)1.67091269
79Overgrowth (HP:0001548)1.65810945
80Achilles tendon contracture (HP:0001771)1.65195155
81Muscle fiber splitting (HP:0003555)1.65120086
82Bowel diverticulosis (HP:0005222)1.63890092
83Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.63467667
84Distal arthrogryposis (HP:0005684)1.62492727
85Short palpebral fissure (HP:0012745)1.62223131
86Decreased motor nerve conduction velocity (HP:0003431)1.61953500
87Fragile skin (HP:0001030)1.61717798
88Long clavicles (HP:0000890)1.61707376
89Back pain (HP:0003418)1.61007145
90Abnormality of the radial head (HP:0003995)1.60196846
91Long palpebral fissure (HP:0000637)1.59740958
92Abnormality of the fingertips (HP:0001211)1.59269353
93Easy fatigability (HP:0003388)1.58168077
94Termporal pattern (HP:0011008)1.57960116
95Insidious onset (HP:0003587)1.57960116
96Vertebral arch anomaly (HP:0008438)1.57267207
97Malignant hyperthermia (HP:0002047)1.57227331
98Pointed chin (HP:0000307)1.56811301
99Limb-girdle muscle weakness (HP:0003325)1.55533389
100Germ cell neoplasia (HP:0100728)1.54134342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.46222357
2PINK13.45762924
3PRPF4B3.34661882
4TRIB33.27191034
5CDK123.11899265
6ICK2.66949206
7MAP3K102.63621424
8TTN2.44066768
9LATS12.24829171
10BRD42.19023559
11LATS22.08116211
12OBSCN1.99886357
13SIK11.81377916
14MARK31.74929959
15PKN21.71574505
16IRAK21.67389176
17PDGFRA1.58471402
18RIPK11.57965357
19MAP3K61.54490345
20MAP2K31.45692098
21MAP3K131.44096370
22KSR21.40073074
23MTOR1.39862856
24MAP3K71.23481493
25MAP3K11.22494736
26SIK21.19170350
27NEK91.18834577
28IRAK31.16443210
29SCYL21.13979118
30SGK31.11818189
31RET1.07682321
32MARK21.07284187
33EPHB11.03500229
34FGFR41.03394310
35SMG10.98509376
36MAP3K140.98058395
37SGK20.97884983
38MAP3K90.93419791
39CLK10.93278344
40NTRK10.90346091
41FGFR30.86621454
42NEK20.86018560
43PDGFRB0.83994151
44SIK30.83993313
45RPS6KA20.83687052
46RPS6KA40.80738015
47SGK2230.80302350
48SGK4940.80302350
49AKT30.79214059
50ZAP700.78039597
51MAPK120.76703568
52RPS6KB10.75502063
53IRAK40.74333952
54MOS0.73844889
55MAP2K70.72827235
56EPHA20.72594394
57MAP3K50.71751874
58KSR10.71630044
59TRPM70.70422376
60CDC42BPA0.69388336
61CAMK1D0.68645931
62CCNB10.67762877
63PAK20.67343758
64RPS6KC10.62608146
65RPS6KL10.62608146
66PDPK10.61382262
67PIK3CG0.59392534
68STK380.58358917
69CDK40.57182182
70CDK60.56887659
71PRKD20.55627337
72IKBKE0.55144768
73TAOK20.54835570
74DYRK30.53872877
75CAMK40.52303241
76MAP2K40.52229261
77TBK10.51643426
78RPS6KA10.51546026
79MAPK110.50927212
80ERN10.49454589
81ARAF0.45595359
82IRAK10.45473733
83RAF10.44820630
84PRKG20.44083730
85DYRK1B0.43678881
86HIPK20.40580167
87PDK10.40381158
88BTK0.39109576
89FLT30.38724722
90MAPK100.38689847
91PHKG20.38236827
92PHKG10.38236827
93YES10.37625966
94WNK10.37284071
95MELK0.36661452
96FGFR20.36287871
97RPS6KA60.36013652
98PTK20.35922008
99CDK80.35848399
100JAK10.35617019

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052201.94977306
2Endometrial cancer_Homo sapiens_hsa052131.84758461
3Non-small cell lung cancer_Homo sapiens_hsa052231.83662019
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81947039
5Acute myeloid leukemia_Homo sapiens_hsa052211.74641696
6mTOR signaling pathway_Homo sapiens_hsa041501.61068430
7Central carbon metabolism in cancer_Homo sapiens_hsa052301.54250475
8Longevity regulating pathway - mammal_Homo sapiens_hsa042111.47701017
9Glioma_Homo sapiens_hsa052141.42093802
10Thyroid hormone signaling pathway_Homo sapiens_hsa049191.38439062
11Neurotrophin signaling pathway_Homo sapiens_hsa047221.37039690
12Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35721288
13Phosphatidylinositol signaling system_Homo sapiens_hsa040701.35514962
14Focal adhesion_Homo sapiens_hsa045101.35469952
15B cell receptor signaling pathway_Homo sapiens_hsa046621.33707163
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33136080
17ErbB signaling pathway_Homo sapiens_hsa040121.32156709
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31012648
19Insulin signaling pathway_Homo sapiens_hsa049101.30894592
20AMPK signaling pathway_Homo sapiens_hsa041521.29750573
21Pancreatic cancer_Homo sapiens_hsa052121.29635500
22Thyroid cancer_Homo sapiens_hsa052161.27866599
23Prostate cancer_Homo sapiens_hsa052151.26529611
24VEGF signaling pathway_Homo sapiens_hsa043701.25535790
25MicroRNAs in cancer_Homo sapiens_hsa052061.25340224
26Small cell lung cancer_Homo sapiens_hsa052221.25096840
27Notch signaling pathway_Homo sapiens_hsa043301.24909096
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23609651
29Renal cell carcinoma_Homo sapiens_hsa052111.23193348
30Hepatitis B_Homo sapiens_hsa051611.22976368
31Inositol phosphate metabolism_Homo sapiens_hsa005621.21651247
32Bladder cancer_Homo sapiens_hsa052191.20204225
33Choline metabolism in cancer_Homo sapiens_hsa052311.16249887
34Dilated cardiomyopathy_Homo sapiens_hsa054141.14299766
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13849185
36Long-term potentiation_Homo sapiens_hsa047201.13198483
37FoxO signaling pathway_Homo sapiens_hsa040681.08662897
38Estrogen signaling pathway_Homo sapiens_hsa049151.06701797
39Proteoglycans in cancer_Homo sapiens_hsa052051.04952138
40GnRH signaling pathway_Homo sapiens_hsa049121.04645682
41ECM-receptor interaction_Homo sapiens_hsa045121.04052521
42Colorectal cancer_Homo sapiens_hsa052101.03367117
43Gap junction_Homo sapiens_hsa045401.02648057
44Insulin resistance_Homo sapiens_hsa049311.00547186
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00273119
46Prolactin signaling pathway_Homo sapiens_hsa049170.98688047
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97449256
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96955043
49Adherens junction_Homo sapiens_hsa045200.96293746
50T cell receptor signaling pathway_Homo sapiens_hsa046600.95915912
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95212278
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95200995
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92327544
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.90637973
55Apoptosis_Homo sapiens_hsa042100.89790745
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.89434904
57Circadian rhythm_Homo sapiens_hsa047100.88370523
58Oxytocin signaling pathway_Homo sapiens_hsa049210.86643159
59Lysine degradation_Homo sapiens_hsa003100.86110698
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84483861
61Platelet activation_Homo sapiens_hsa046110.82997264
62Glucagon signaling pathway_Homo sapiens_hsa049220.82944811
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82276515
64Viral carcinogenesis_Homo sapiens_hsa052030.80673785
65Other glycan degradation_Homo sapiens_hsa005110.80561996
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78842244
67Hedgehog signaling pathway_Homo sapiens_hsa043400.78077220
68Melanogenesis_Homo sapiens_hsa049160.77155295
69MAPK signaling pathway_Homo sapiens_hsa040100.76733257
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.76649960
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76531448
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76307530
73Amoebiasis_Homo sapiens_hsa051460.75243821
74Melanoma_Homo sapiens_hsa052180.75042954
75Type II diabetes mellitus_Homo sapiens_hsa049300.74637176
76Hepatitis C_Homo sapiens_hsa051600.74483781
77Prion diseases_Homo sapiens_hsa050200.74067335
78TNF signaling pathway_Homo sapiens_hsa046680.73972161
79mRNA surveillance pathway_Homo sapiens_hsa030150.73477566
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73385394
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73289339
82Osteoclast differentiation_Homo sapiens_hsa043800.71910350
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71802598
84Cholinergic synapse_Homo sapiens_hsa047250.70087352
85Pentose phosphate pathway_Homo sapiens_hsa000300.68675026
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66817200
87HTLV-I infection_Homo sapiens_hsa051660.64893380
88HIF-1 signaling pathway_Homo sapiens_hsa040660.64775330
89Pathways in cancer_Homo sapiens_hsa052000.64562108
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62835541
91Axon guidance_Homo sapiens_hsa043600.62721816
92Hippo signaling pathway_Homo sapiens_hsa043900.59984203
93Measles_Homo sapiens_hsa051620.59863811
94Toxoplasmosis_Homo sapiens_hsa051450.59191438
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58711411
96Rap1 signaling pathway_Homo sapiens_hsa040150.58187046
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57465413
98Influenza A_Homo sapiens_hsa051640.57175131
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56262392
100Endocytosis_Homo sapiens_hsa041440.55540489

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