BEND6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.32650302
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.24981403
3locomotory exploration behavior (GO:0035641)5.82136458
4synaptic vesicle exocytosis (GO:0016079)5.72657060
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.55237682
6glutamate secretion (GO:0014047)5.54473181
7regulation of synaptic vesicle exocytosis (GO:2000300)5.47461810
8vocalization behavior (GO:0071625)5.43324333
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.41464206
10neuronal action potential propagation (GO:0019227)5.23082528
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.07885667
12neurotransmitter secretion (GO:0007269)5.00668579
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.94309353
14regulation of synaptic vesicle transport (GO:1902803)4.87484392
15regulation of glutamate receptor signaling pathway (GO:1900449)4.73806231
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.70747610
17gamma-aminobutyric acid transport (GO:0015812)4.63234760
18exploration behavior (GO:0035640)4.57967577
19protein localization to synapse (GO:0035418)4.53628440
20neuron cell-cell adhesion (GO:0007158)4.45903658
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.35431982
22cellular potassium ion homeostasis (GO:0030007)4.31811488
23layer formation in cerebral cortex (GO:0021819)4.31107075
24regulation of neuronal synaptic plasticity (GO:0048168)4.29681397
25synaptic transmission, glutamatergic (GO:0035249)4.22031155
26glutamate receptor signaling pathway (GO:0007215)4.20554387
27neuron-neuron synaptic transmission (GO:0007270)4.13101314
28neurotransmitter transport (GO:0006836)4.08775795
29proline transport (GO:0015824)4.06739984
30regulation of synapse structural plasticity (GO:0051823)4.01920747
31neuromuscular process controlling posture (GO:0050884)4.01334440
32sodium ion export (GO:0071436)4.00575013
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.98700494
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.98416643
35glycine transport (GO:0015816)3.98221205
36cerebellar Purkinje cell differentiation (GO:0021702)3.94241279
37long-term memory (GO:0007616)3.88756276
38neurotransmitter-gated ion channel clustering (GO:0072578)3.84707694
39regulation of neurotransmitter levels (GO:0001505)3.75866428
40activation of protein kinase A activity (GO:0034199)3.72754610
41positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.72193223
42synaptic vesicle endocytosis (GO:0048488)3.70405430
43dendritic spine morphogenesis (GO:0060997)3.64898776
44negative regulation of synaptic transmission, GABAergic (GO:0032229)3.62619012
45positive regulation of membrane potential (GO:0045838)3.62571855
46regulation of neurotransmitter secretion (GO:0046928)3.61348147
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.61003079
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.60715598
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.59458253
50transmission of nerve impulse (GO:0019226)3.52561965
51axon ensheathment in central nervous system (GO:0032291)3.52513243
52central nervous system myelination (GO:0022010)3.52513243
53neuromuscular process controlling balance (GO:0050885)3.50000502
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.48772138
55cerebellar granule cell differentiation (GO:0021707)3.47768320
56positive regulation of synapse maturation (GO:0090129)3.46177949
57regulation of postsynaptic membrane potential (GO:0060078)3.45969397
58regulation of synaptic plasticity (GO:0048167)3.44505547
59neuron recognition (GO:0008038)3.44285954
60regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.43709652
61serotonin metabolic process (GO:0042428)3.42911594
62positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.38430240
63long-term synaptic potentiation (GO:0060291)3.36819813
64cell communication by electrical coupling (GO:0010644)3.36451502
65regulation of neurotransmitter transport (GO:0051588)3.35663130
66regulation of vesicle fusion (GO:0031338)3.32268983
67L-amino acid import (GO:0043092)3.31082225
68membrane depolarization during action potential (GO:0086010)3.29931229
69neurotransmitter uptake (GO:0001504)3.29824576
70regulation of dendritic spine development (GO:0060998)3.28223537
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.27891909
72presynaptic membrane assembly (GO:0097105)3.27453982
73negative regulation of dendrite development (GO:2000171)3.27415114
74postsynaptic membrane organization (GO:0001941)3.27338712
75response to pheromone (GO:0019236)3.26023975
76regulation of synaptic transmission, glutamatergic (GO:0051966)3.25730931
77dendrite morphogenesis (GO:0048813)3.24783009
78negative regulation of dendrite morphogenesis (GO:0050774)3.23837939
79response to auditory stimulus (GO:0010996)3.22212101
80presynaptic membrane organization (GO:0097090)3.21950541
81positive regulation of synaptic transmission, GABAergic (GO:0032230)3.21618470
82adult walking behavior (GO:0007628)3.19606976
83regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.18099171
84retinal cone cell development (GO:0046549)3.16315448
85vesicle transport along microtubule (GO:0047496)3.15936027
86positive regulation of dendritic spine development (GO:0060999)3.14585269
87membrane hyperpolarization (GO:0060081)3.13996448
88membrane depolarization (GO:0051899)3.13954953
89axonal fasciculation (GO:0007413)3.13261349
90detection of calcium ion (GO:0005513)3.12838957
91regulation of dendritic spine morphogenesis (GO:0061001)3.12021694
92positive regulation of potassium ion transmembrane transport (GO:1901381)3.11329971
93vesicle docking involved in exocytosis (GO:0006904)3.11239351
94auditory behavior (GO:0031223)3.11109733
95neuromuscular process (GO:0050905)3.10468099
96negative regulation of neurotransmitter transport (GO:0051589)3.10144207
97potassium ion import (GO:0010107)3.09513102
98synaptic transmission (GO:0007268)3.08649744
99cell migration in hindbrain (GO:0021535)3.07923034
100vesicle docking (GO:0048278)3.07859922
101righting reflex (GO:0060013)3.07668818
102synapse assembly (GO:0007416)3.07261430
103prepulse inhibition (GO:0060134)3.07244601
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.07189434
105positive regulation of neurotransmitter transport (GO:0051590)3.02313646
106regulation of neurotransmitter uptake (GO:0051580)3.02300122
107C4-dicarboxylate transport (GO:0015740)3.02280130
108regulation of synaptic transmission (GO:0050804)3.01404381
109primary amino compound metabolic process (GO:1901160)3.00450576
110neuronal ion channel clustering (GO:0045161)2.99033589
111regulation of voltage-gated calcium channel activity (GO:1901385)2.98767162
112learning (GO:0007612)2.97866276
113startle response (GO:0001964)2.96929010
114positive regulation of synaptic transmission (GO:0050806)2.96703468
115organelle transport along microtubule (GO:0072384)2.95710005
116potassium ion homeostasis (GO:0055075)2.95601613
117positive regulation of neurotransmitter secretion (GO:0001956)2.91884039
118intraspecies interaction between organisms (GO:0051703)2.91722933
119social behavior (GO:0035176)2.91722933
120detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.91544297
121calcium ion-dependent exocytosis (GO:0017156)2.90947992
122positive regulation of dendritic spine morphogenesis (GO:0061003)2.89223403
123amino acid import (GO:0043090)2.87280380
124potassium ion transmembrane transport (GO:0071805)2.85912779
125cellular potassium ion transport (GO:0071804)2.85912779
126behavioral defense response (GO:0002209)2.85565008
127behavioral fear response (GO:0001662)2.85565008
128central nervous system projection neuron axonogenesis (GO:0021952)2.84918068
129positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.84362233
130regulation of cell communication by electrical coupling (GO:0010649)2.83814893
131neuromuscular synaptic transmission (GO:0007274)2.79550871
132acidic amino acid transport (GO:0015800)2.78984566

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.91293112
2GBX2_23144817_ChIP-Seq_PC3_Human3.45785912
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18388385
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13965725
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08511463
6REST_21632747_ChIP-Seq_MESCs_Mouse2.84871573
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77795467
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77795467
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64372500
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60819162
11DROSHA_22980978_ChIP-Seq_HELA_Human2.59782292
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57209797
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55952656
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53305567
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51236052
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.46464480
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.39749236
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.36648362
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.30926229
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.25586434
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.25110822
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.24199471
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23499906
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.16627743
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10636837
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08343852
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02871602
28AR_21572438_ChIP-Seq_LNCaP_Human1.98676285
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95727816
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93226632
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86409904
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75213134
33TAF15_26573619_Chip-Seq_HEK293_Human1.75029334
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74353339
35FUS_26573619_Chip-Seq_HEK293_Human1.71709701
36SMAD4_21799915_ChIP-Seq_A2780_Human1.69234474
37* FLI1_27457419_Chip-Seq_LIVER_Mouse1.68561251
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65395299
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63537773
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.56344208
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53642974
42VDR_22108803_ChIP-Seq_LS180_Human1.50760048
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.45146899
44* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44062235
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43722848
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43392227
47ZNF274_21170338_ChIP-Seq_K562_Hela1.40854717
48* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40092800
49* NANOG_18555785_Chip-Seq_ESCs_Mouse1.38113815
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.37381726
51RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35479420
52TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34814321
53* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34353322
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.32591258
55P300_19829295_ChIP-Seq_ESCs_Human1.32053685
56EWS_26573619_Chip-Seq_HEK293_Human1.31731969
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31419135
58* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30409834
59* RING1B_27294783_Chip-Seq_ESCs_Mouse1.28367629
60FLI1_21867929_ChIP-Seq_TH2_Mouse1.27991834
61AR_25329375_ChIP-Seq_VCAP_Human1.27403467
62* CBP_20019798_ChIP-Seq_JUKART_Human1.26044440
63* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26044440
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25593349
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24779281
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23665092
67AR_19668381_ChIP-Seq_PC3_Human1.23428586
68STAT3_23295773_ChIP-Seq_U87_Human1.23052594
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22490670
70BCAT_22108803_ChIP-Seq_LS180_Human1.20285814
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19411551
72* KDM2B_26808549_Chip-Seq_REH_Human1.19311477
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19128253
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.18984896
75TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18615934
76* P53_22387025_ChIP-Seq_ESCs_Mouse1.16778247
77* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16551896
78* EZH2_27294783_Chip-Seq_NPCs_Mouse1.16449309
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16228558
80IGF1R_20145208_ChIP-Seq_DFB_Human1.16208472
81* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15949233
82* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15845253
83TP53_18474530_ChIP-ChIP_U2OS_Human1.15144625
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14989340
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14906869
86* SMAD4_21741376_ChIP-Seq_EPCs_Human1.14056015
87* E2F1_18555785_Chip-Seq_ESCs_Mouse1.13484448
88* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13125361
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.13058084
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.12152933
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11709609
92TCF4_22108803_ChIP-Seq_LS180_Human1.11658093
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10788325
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10788325
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10109682
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10061512
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10061512
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08901252
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08504555
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08039658
101RNF2_27304074_Chip-Seq_NSC_Mouse1.07059642
102* TCF4_23295773_ChIP-Seq_U87_Human1.05644697
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03524706
104* KDM2B_26808549_Chip-Seq_K562_Human1.03275826
105* RING1B_27294783_Chip-Seq_NPCs_Mouse1.02704557
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02551957
107ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02220047
108EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02093712
109YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02053119
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.01248991
111ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98758826
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97437710
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97273077
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96406028
115AHR_22903824_ChIP-Seq_MCF-7_Human0.95988897
116RUNX2_22187159_ChIP-Seq_PCA_Human0.95665093
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95617137
118POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94143469
119* SMAD3_21741376_ChIP-Seq_ESCs_Human0.93587502
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.92437826
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91805910
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.90912729
123TP53_16413492_ChIP-PET_HCT116_Human0.90581585
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90561140
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90028484
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88896634
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86081713
128RXR_22108803_ChIP-Seq_LS180_Human0.85658151
129CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85640155
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85605062
131JUN_21703547_ChIP-Seq_K562_Human0.84882095
132TET1_21490601_ChIP-Seq_MESCs_Mouse0.84608449
133ER_23166858_ChIP-Seq_MCF-7_Human0.83518858
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.83139741

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.34386395
2MP0003880_abnormal_central_pattern4.85280733
3MP0003635_abnormal_synaptic_transmissio4.26460847
4MP0004270_analgesia3.69632390
5MP0009046_muscle_twitch3.67520476
6MP0009745_abnormal_behavioral_response3.47678000
7MP0002064_seizures3.32444641
8MP0002063_abnormal_learning/memory/cond3.27896985
9MP0001968_abnormal_touch/_nociception3.20727578
10MP0005423_abnormal_somatic_nervous3.00372710
11MP0002734_abnormal_mechanical_nocicepti2.83833591
12MP0002572_abnormal_emotion/affect_behav2.77908716
13MP0002272_abnormal_nervous_system2.77659010
14MP0001486_abnormal_startle_reflex2.69046149
15MP0002736_abnormal_nociception_after2.48630154
16MP0002735_abnormal_chemical_nociception2.48314249
17MP0001501_abnormal_sleep_pattern2.40659746
18MP0008569_lethality_at_weaning2.28956415
19MP0002733_abnormal_thermal_nociception2.24416499
20MP0001440_abnormal_grooming_behavior2.24369144
21MP0002067_abnormal_sensory_capabilities2.21010621
22MP0001970_abnormal_pain_threshold2.13295166
23MP0002822_catalepsy2.04830663
24MP0002184_abnormal_innervation1.94780813
25MP0003329_amyloid_beta_deposits1.92919374
26MP0008877_abnormal_DNA_methylation1.87861230
27MP0005386_behavior/neurological_phenoty1.83356638
28MP0004924_abnormal_behavior1.83356638
29MP0004811_abnormal_neuron_physiology1.81961142
30MP0004858_abnormal_nervous_system1.81544756
31MP0006276_abnormal_autonomic_nervous1.81369385
32MP0002557_abnormal_social/conspecific_i1.78705709
33MP0009780_abnormal_chondrocyte_physiolo1.77701746
34MP0000778_abnormal_nervous_system1.74798304
35MP0002909_abnormal_adrenal_gland1.67939651
36MP0000955_abnormal_spinal_cord1.67446728
37MP0004142_abnormal_muscle_tone1.65969874
38MP0004885_abnormal_endolymph1.57607401
39MP0005646_abnormal_pituitary_gland1.54049544
40MP0003787_abnormal_imprinting1.52960362
41MP0002066_abnormal_motor_capabilities/c1.50513455
42MP0003879_abnormal_hair_cell1.50458258
43MP0002882_abnormal_neuron_morphology1.42378861
44MP0003633_abnormal_nervous_system1.41500083
45MP0001984_abnormal_olfaction1.37941590
46MP0003122_maternal_imprinting1.27906618
47MP0005645_abnormal_hypothalamus_physiol1.27694633
48MP0003631_nervous_system_phenotype1.22323033
49MP0001502_abnormal_circadian_rhythm1.20815998
50MP0004145_abnormal_muscle_electrophysio1.16192366
51MP0001905_abnormal_dopamine_level1.15839414
52MP0000569_abnormal_digit_pigmentation1.11923966
53MP0004043_abnormal_pH_regulation1.11441413
54MP0002152_abnormal_brain_morphology1.08544488
55MP0001529_abnormal_vocalization1.07907382
56MP0001188_hyperpigmentation1.06952583
57MP0003195_calcinosis1.05898347
58MP0004147_increased_porphyrin_level1.05160907
59MP0008872_abnormal_physiological_respon1.04680716
60MP0002229_neurodegeneration1.03582728
61MP0004742_abnormal_vestibular_system1.02091865
62MP0003690_abnormal_glial_cell1.00860302
63MP0000751_myopathy0.98629587
64MP0005171_absent_coat_pigmentation0.97667072
65MP0003632_abnormal_nervous_system0.96332432
66MP0000920_abnormal_myelination0.93738508
67MP0003123_paternal_imprinting0.91768757
68MP0003634_abnormal_glial_cell0.90050187
69MP0002234_abnormal_pharynx_morphology0.89786215
70MP0001177_atelectasis0.88588330
71MP0008874_decreased_physiological_sensi0.87906777
72MP0000604_amyloidosis0.87016546
73MP0002069_abnormal_eating/drinking_beha0.86677805
74MP0001963_abnormal_hearing_physiology0.84884249
75MP0005174_abnormal_tail_pigmentation0.84818625
76MP0005551_abnormal_eye_electrophysiolog0.83326528
77MP0000013_abnormal_adipose_tissue0.82450171
78MP0005535_abnormal_body_temperature0.79677201
79MP0003283_abnormal_digestive_organ0.78296947
80MP0005623_abnormal_meninges_morphology0.77122836
81MP0000427_abnormal_hair_cycle0.76772596
82MP0004484_altered_response_of0.76172328
83MP0010386_abnormal_urinary_bladder0.75550313
84MP0003172_abnormal_lysosome_physiology0.75357503
85MP0003075_altered_response_to0.75340445
86MP0001986_abnormal_taste_sensitivity0.75231714
87MP0004085_abnormal_heartbeat0.75187772
88MP0002752_abnormal_somatic_nervous0.75037729
89MP0002102_abnormal_ear_morphology0.74916352
90MP0003045_fibrosis0.74354868
91MP0004215_abnormal_myocardial_fiber0.71775274
92MP0005499_abnormal_olfactory_system0.71695148
93MP0005394_taste/olfaction_phenotype0.71695148
94MP0003121_genomic_imprinting0.68399396
95MP0003137_abnormal_impulse_conducting0.67083830
96MP0008961_abnormal_basal_metabolism0.65952018
97MP0002090_abnormal_vision0.65203773
98MP0001299_abnormal_eye_distance/0.65157584
99MP0003950_abnormal_plasma_membrane0.64889468
100MP0002928_abnormal_bile_duct0.64518066
101MP0005253_abnormal_eye_physiology0.64353583
102MP0001485_abnormal_pinna_reflex0.62603297
103MP0000631_abnormal_neuroendocrine_gland0.60476846
104MP0002638_abnormal_pupillary_reflex0.59171832
105MP0004233_abnormal_muscle_weight0.58350175
106MP0005167_abnormal_blood-brain_barrier0.58135407
107MP0004510_myositis0.57585041
108MP0010769_abnormal_survival0.56991705
109MP0004084_abnormal_cardiac_muscle0.56945601
110MP0006054_spinal_hemorrhage0.56525673
111MP0001943_abnormal_respiration0.55310274
112MP0002837_dystrophic_cardiac_calcinosis0.55240735
113MP0002082_postnatal_lethality0.54678134
114MP0010770_preweaning_lethality0.54678134
115MP0001348_abnormal_lacrimal_gland0.53968510
116MP0010768_mortality/aging0.53196064
117MP0005503_abnormal_tendon_morphology0.53036445
118MP0004036_abnormal_muscle_relaxation0.52724259
119MP0003956_abnormal_body_size0.51596990
120MP0001664_abnormal_digestion0.51321812
121MP0008438_abnormal_cutaneous_collagen0.49635224
122MP0008057_abnormal_DNA_replication0.49382285

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.77749994
2Myokymia (HP:0002411)6.74815508
3Focal seizures (HP:0007359)5.84087570
4Visual hallucinations (HP:0002367)5.69690654
5Atonic seizures (HP:0010819)5.12111783
6Febrile seizures (HP:0002373)4.94870665
7Progressive cerebellar ataxia (HP:0002073)4.89911589
8Epileptic encephalopathy (HP:0200134)4.83956584
9Action tremor (HP:0002345)4.59028509
10Absence seizures (HP:0002121)4.37739637
11Supranuclear gaze palsy (HP:0000605)4.22606923
12Generalized tonic-clonic seizures (HP:0002069)4.03435740
13Dialeptic seizures (HP:0011146)3.91558909
14Ankle clonus (HP:0011448)3.58620009
15Gaze-evoked nystagmus (HP:0000640)3.56524044
16Mutism (HP:0002300)3.52541608
17Broad-based gait (HP:0002136)3.47238702
18Poor eye contact (HP:0000817)3.44161262
19Dysdiadochokinesis (HP:0002075)3.42760589
20Abnormal eating behavior (HP:0100738)3.27580289
21Truncal ataxia (HP:0002078)3.26772898
22Depression (HP:0000716)3.26409185
23Papilledema (HP:0001085)3.23246279
24Postural instability (HP:0002172)3.15759720
25Urinary bladder sphincter dysfunction (HP:0002839)3.15604807
26Impaired vibration sensation in the lower limbs (HP:0002166)3.14639906
27Abnormal social behavior (HP:0012433)3.13418365
28Impaired social interactions (HP:0000735)3.13418365
29Dysmetria (HP:0001310)3.09582440
30Progressive inability to walk (HP:0002505)3.03378533
31Scanning speech (HP:0002168)2.98715057
32Anxiety (HP:0000739)2.98244887
33Diplopia (HP:0000651)2.94544632
34Abnormality of binocular vision (HP:0011514)2.94544632
35Genetic anticipation (HP:0003743)2.93200881
36Hemiplegia (HP:0002301)2.88734519
37Impaired smooth pursuit (HP:0007772)2.85571474
38Urinary urgency (HP:0000012)2.84711794
39Hyperventilation (HP:0002883)2.84679636
40Intention tremor (HP:0002080)2.81747692
41Hemiparesis (HP:0001269)2.78885950
42Ventricular fibrillation (HP:0001663)2.77355102
43Fetal akinesia sequence (HP:0001989)2.68315844
44Spastic gait (HP:0002064)2.65761567
45Abnormality of the lower motor neuron (HP:0002366)2.64015730
46Amblyopia (HP:0000646)2.63952115
47Status epilepticus (HP:0002133)2.61544394
48Pheochromocytoma (HP:0002666)2.57555138
49Torticollis (HP:0000473)2.56285226
50Bradykinesia (HP:0002067)2.54588063
51Abnormality of ocular smooth pursuit (HP:0000617)2.54484076
52Drooling (HP:0002307)2.51338131
53Excessive salivation (HP:0003781)2.51338131
54Limb dystonia (HP:0002451)2.51200154
55Dysmetric saccades (HP:0000641)2.45237455
56Abnormality of the corticospinal tract (HP:0002492)2.44381375
57Neurofibrillary tangles (HP:0002185)2.39055321
58Termporal pattern (HP:0011008)2.36804363
59Insidious onset (HP:0003587)2.36804363
60Focal dystonia (HP:0004373)2.33563647
61Polyphagia (HP:0002591)2.32824449
62Stereotypic behavior (HP:0000733)2.31597964
63Megalencephaly (HP:0001355)2.29130650
64Cerebral hypomyelination (HP:0006808)2.28683540
65Agitation (HP:0000713)2.26369300
66Inability to walk (HP:0002540)2.25102099
67Neuroendocrine neoplasm (HP:0100634)2.24817578
68Epileptiform EEG discharges (HP:0011182)2.23603167
69Cerebral inclusion bodies (HP:0100314)2.22777831
70Amyotrophic lateral sclerosis (HP:0007354)2.22259017
71Annular pancreas (HP:0001734)2.21187914
72Gait imbalance (HP:0002141)2.20753376
73Absent speech (HP:0001344)2.18791826
74Lower limb muscle weakness (HP:0007340)2.18674098
75EEG with generalized epileptiform discharges (HP:0011198)2.18426667
76Abnormality of saccadic eye movements (HP:0000570)2.14855228
77Impaired vibratory sensation (HP:0002495)2.11358410
78Craniofacial dystonia (HP:0012179)2.10937083
79Hypsarrhythmia (HP:0002521)2.09891611
80Generalized myoclonic seizures (HP:0002123)2.07567751
81Bundle branch block (HP:0011710)2.03629334
82Gait ataxia (HP:0002066)2.02784443
83Protruding tongue (HP:0010808)2.01223664
84Neuronal loss in central nervous system (HP:0002529)2.01018763
85Medial flaring of the eyebrow (HP:0010747)2.00584276
86Blue irides (HP:0000635)1.99304828
87Metaphyseal dysplasia (HP:0100255)1.97625310
88Clonus (HP:0002169)1.97186540
89Failure to thrive in infancy (HP:0001531)1.95871652
90Incomplete penetrance (HP:0003829)1.94433519
91Akinesia (HP:0002304)1.94360491
92Insomnia (HP:0100785)1.93363704
93Increased circulating renin level (HP:0000848)1.92441970
94Pointed chin (HP:0000307)1.92150543
95Spastic paraplegia (HP:0001258)1.90658947
96Inappropriate behavior (HP:0000719)1.90066754
97Obstructive sleep apnea (HP:0002870)1.87740658
98Rigidity (HP:0002063)1.87646305
99Psychosis (HP:0000709)1.87576565
100Lower limb asymmetry (HP:0100559)1.86649370
101Paraplegia (HP:0010550)1.85850748
102Postural tremor (HP:0002174)1.85584331
103Tetraplegia (HP:0002445)1.85444180
104Neoplasm of the peripheral nervous system (HP:0100007)1.83291237
105Morphological abnormality of the pyramidal tract (HP:0002062)1.82859413
106Abnormal EKG (HP:0003115)1.80435426
107Degeneration of the lateral corticospinal tracts (HP:0002314)1.80210300
108Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80210300
109Delusions (HP:0000746)1.79413686
110Pancreatic fibrosis (HP:0100732)1.78880840
111Fair hair (HP:0002286)1.77808966
112Peripheral hypomyelination (HP:0007182)1.77594744
113Central scotoma (HP:0000603)1.74718105
114Pancreatic cysts (HP:0001737)1.72467437
115Congenital primary aphakia (HP:0007707)1.68696379
116True hermaphroditism (HP:0010459)1.68493914
117Spastic tetraparesis (HP:0001285)1.66033155
118Prolonged QT interval (HP:0001657)1.65091726
119Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.61474643
120Congenital stationary night blindness (HP:0007642)1.59643181
121Dyskinesia (HP:0100660)1.57567634
122Generalized hypopigmentation of hair (HP:0011358)1.57416780
123Hypothermia (HP:0002045)1.56714458
124Increased corneal curvature (HP:0100692)1.54519819
125Keratoconus (HP:0000563)1.54519819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.07828730
2NTRK34.31158239
3MAP3K93.93114181
4MARK13.57100805
5MAP3K43.41938016
6EPHA43.03636865
7MINK13.02899746
8MAP2K72.94611351
9MAP3K122.61877673
10PAK62.34051150
11MAP2K42.28810946
12DAPK22.18918961
13CAMKK12.10950651
14NTRK22.07807595
15KSR21.81191090
16CASK1.79603716
17NTRK11.77790665
18RIPK41.74149075
19CDK191.73930575
20PRKD31.66735339
21STK381.62102319
22CAMKK21.57994153
23PLK21.55675580
24GRK51.49754451
25CDK51.48215058
26MAPK131.44695396
27KSR11.34860841
28LATS21.33002525
29PRKCG1.30683300
30TNIK1.28122224
31PHKG21.26596923
32PHKG11.26596923
33DAPK11.25900929
34STK391.23566389
35SIK21.23446671
36MAP4K21.22459768
37BMPR1B1.19755132
38UHMK11.19543769
39ARAF1.15426270
40PNCK1.14297290
41PINK11.12874416
42TRIM281.12217861
43WNK11.12186921
44ACVR1B1.09049248
45PRPF4B1.08153298
46FES1.03968355
47SGK2231.02049775
48SGK4941.02049775
49STK38L1.01243709
50LMTK21.00571463
51CDK180.94842365
52PRKCH0.93920866
53TYRO30.93689539
54STK110.93108449
55CDK150.93041340
56NUAK10.92044847
57SGK20.90610546
58CDK140.89717550
59CAMK2A0.89061038
60MAP3K20.88465212
61MAP3K130.88088367
62CAMK10.84992633
63RET0.84886499
64OXSR10.84162784
65TAOK10.83532626
66PKN10.82365422
67CDK11A0.80900616
68SGK30.80774898
69WNK30.80251253
70TNK20.78069710
71ALK0.77591072
72AKT30.75909983
73FGFR20.71368587
74SCYL20.70437985
75CSNK1G20.69148850
76PAK30.68468400
77PIK3CG0.67996010
78DYRK1A0.67707941
79CAMK2B0.64885478
80PDK10.64435365
81ADRBK20.64321397
82LATS10.63603161
83BMPR20.63240167
84SGK10.62944433
85ADRBK10.61914533
86RIPK10.60162750
87ROCK10.59716234
88NEK10.59654654
89RAF10.58349027
90PDPK10.58049737
91WNK40.57842036
92CAMK2G0.57454679
93BCR0.55861563
94MKNK20.55810598
95CDC42BPA0.54798443
96INSRR0.53970841
97LIMK10.53484338
98MAP3K10.52795882
99CCNB10.52546639
100PRKCE0.52235823
101MYLK0.51951276
102NEK60.51451878
103BRSK10.50149554
104PRKCZ0.50033523
105MARK20.49978602
106GRK10.49661605
107ERBB30.48231118
108RPS6KA30.48135690
109PIK3CA0.45536365
110PLK30.43404543
111MAPK100.43277668
112CAMK2D0.42578408
113FYN0.41994449
114CSNK1D0.41759054
115PRKG10.41072626
116ROCK20.39965767
117PRKCA0.39205376
118CAMK1G0.38694544
119PTK2B0.37580561
120CAMK40.36929035
121FER0.35303973
122MAPK120.32031321
123RPS6KA20.31666835
124MAPKAPK50.31310485
125MAP3K60.31192916
126PRKCB0.31133186
127MAP2K10.30481463
128GRK70.30314591

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.82401072
2Synaptic vesicle cycle_Homo sapiens_hsa047213.62342640
3GABAergic synapse_Homo sapiens_hsa047272.78429080
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65628146
5Olfactory transduction_Homo sapiens_hsa047402.63355138
6Circadian entrainment_Homo sapiens_hsa047132.60855708
7Long-term potentiation_Homo sapiens_hsa047202.57375531
8Glutamatergic synapse_Homo sapiens_hsa047242.54730065
9Morphine addiction_Homo sapiens_hsa050322.46225188
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38542496
11Amphetamine addiction_Homo sapiens_hsa050312.29032250
12Salivary secretion_Homo sapiens_hsa049702.15033579
13Dopaminergic synapse_Homo sapiens_hsa047282.12121834
14Insulin secretion_Homo sapiens_hsa049111.93899195
15Gastric acid secretion_Homo sapiens_hsa049711.93043478
16Taste transduction_Homo sapiens_hsa047421.84788031
17Cholinergic synapse_Homo sapiens_hsa047251.84603618
18Long-term depression_Homo sapiens_hsa047301.76565220
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74144461
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68951573
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66949756
22Serotonergic synapse_Homo sapiens_hsa047261.59885949
23Renin secretion_Homo sapiens_hsa049241.59022860
24Oxytocin signaling pathway_Homo sapiens_hsa049211.56463833
25Collecting duct acid secretion_Homo sapiens_hsa049661.50862069
26Calcium signaling pathway_Homo sapiens_hsa040201.49710685
27Cocaine addiction_Homo sapiens_hsa050301.48325169
28GnRH signaling pathway_Homo sapiens_hsa049121.43208209
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42161539
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35774946
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34760539
32Gap junction_Homo sapiens_hsa045401.32827236
33cAMP signaling pathway_Homo sapiens_hsa040241.24395149
34Vitamin B6 metabolism_Homo sapiens_hsa007501.21352429
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16883824
36Type II diabetes mellitus_Homo sapiens_hsa049301.15858859
37Estrogen signaling pathway_Homo sapiens_hsa049151.14019494
38Nitrogen metabolism_Homo sapiens_hsa009101.10505890
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08562236
40Cardiac muscle contraction_Homo sapiens_hsa042601.03270158
41Butanoate metabolism_Homo sapiens_hsa006501.02120684
42Glioma_Homo sapiens_hsa052141.02044870
43Axon guidance_Homo sapiens_hsa043601.00660279
44ErbB signaling pathway_Homo sapiens_hsa040121.00177982
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99203827
46Melanogenesis_Homo sapiens_hsa049160.95475573
47Vibrio cholerae infection_Homo sapiens_hsa051100.94480818
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93751299
49Oocyte meiosis_Homo sapiens_hsa041140.91277487
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90288307
51Dorso-ventral axis formation_Homo sapiens_hsa043200.85348547
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84981058
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84713409
54Pancreatic secretion_Homo sapiens_hsa049720.83948402
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.82541630
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.78862769
57Thyroid hormone synthesis_Homo sapiens_hsa049180.78667622
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75546361
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73820506
60MAPK signaling pathway_Homo sapiens_hsa040100.71204490
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70943680
62Dilated cardiomyopathy_Homo sapiens_hsa054140.69418049
63Phototransduction_Homo sapiens_hsa047440.69323410
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.68335136
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65685850
66Choline metabolism in cancer_Homo sapiens_hsa052310.64076916
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63923929
68Type I diabetes mellitus_Homo sapiens_hsa049400.61627558
69Propanoate metabolism_Homo sapiens_hsa006400.60619011
70Inositol phosphate metabolism_Homo sapiens_hsa005620.58919975
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57701453
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57294044
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56973361
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.54608760
75Ras signaling pathway_Homo sapiens_hsa040140.54375320
76Bile secretion_Homo sapiens_hsa049760.53840363
77Regulation of autophagy_Homo sapiens_hsa041400.53817592
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53164434
79Endocytosis_Homo sapiens_hsa041440.52244904
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51631043
81VEGF signaling pathway_Homo sapiens_hsa043700.51503814
82Glucagon signaling pathway_Homo sapiens_hsa049220.50727998
83ABC transporters_Homo sapiens_hsa020100.50719301
84Rap1 signaling pathway_Homo sapiens_hsa040150.50486795
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49915867
86beta-Alanine metabolism_Homo sapiens_hsa004100.49656760
87Tryptophan metabolism_Homo sapiens_hsa003800.49332539
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.46951877
89mTOR signaling pathway_Homo sapiens_hsa041500.46056398
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45981249
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44524110
92Ether lipid metabolism_Homo sapiens_hsa005650.43904160
93Endometrial cancer_Homo sapiens_hsa052130.42625126
94Alcoholism_Homo sapiens_hsa050340.42091646
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42052939
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40454151
97Prion diseases_Homo sapiens_hsa050200.39330255
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38420611
99Insulin signaling pathway_Homo sapiens_hsa049100.38230804
100Melanoma_Homo sapiens_hsa052180.37691495
101Renal cell carcinoma_Homo sapiens_hsa052110.37399774
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36513634
103Alzheimers disease_Homo sapiens_hsa050100.35868123
104Chemokine signaling pathway_Homo sapiens_hsa040620.35629377
105Ovarian steroidogenesis_Homo sapiens_hsa049130.35503692
106Fatty acid biosynthesis_Homo sapiens_hsa000610.35436059
107Circadian rhythm_Homo sapiens_hsa047100.34555368
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34286534
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34071675
110Hippo signaling pathway_Homo sapiens_hsa043900.33291800
111Wnt signaling pathway_Homo sapiens_hsa043100.33276939
112Mineral absorption_Homo sapiens_hsa049780.33118333
113Non-small cell lung cancer_Homo sapiens_hsa052230.32954866
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30806950
115Arginine and proline metabolism_Homo sapiens_hsa003300.28991815
116Histidine metabolism_Homo sapiens_hsa003400.28373238
117African trypanosomiasis_Homo sapiens_hsa051430.25962126
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25693991
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25218322
120Sphingolipid metabolism_Homo sapiens_hsa006000.25173051
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.24269864

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