BEST1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome assembly (GO:0001675)9.59208393
2cell-cell recognition (GO:0009988)9.02621333
3binding of sperm to zona pellucida (GO:0007339)8.99127289
4plasma membrane fusion (GO:0045026)8.77411428
5epithelial cilium movement (GO:0003351)8.53934812
6axonemal dynein complex assembly (GO:0070286)8.52919298
7reproduction (GO:0000003)8.40060448
8spermatid development (GO:0007286)8.26370091
9cilium or flagellum-dependent cell motility (GO:0001539)8.21861760
10motile cilium assembly (GO:0044458)8.04194571
11regulation of cilium movement (GO:0003352)7.49365840
12cilium movement (GO:0003341)6.85216681
13single fertilization (GO:0007338)6.58188422
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.50606704
15piRNA metabolic process (GO:0034587)6.28355106
16sperm capacitation (GO:0048240)6.18631576
17male meiosis (GO:0007140)5.93885797
18synaptonemal complex organization (GO:0070193)5.85707749
19synaptonemal complex assembly (GO:0007130)5.68091024
20spermatogenesis (GO:0007283)5.58683988
21negative regulation of inclusion body assembly (GO:0090084)5.57653522
22male gamete generation (GO:0048232)5.56330437
23fertilization (GO:0009566)5.53304592
24organic cation transport (GO:0015695)5.26653768
25cellular response to ATP (GO:0071318)5.09083896
26gamete generation (GO:0007276)5.08664018
27microtubule depolymerization (GO:0007019)4.92321871
28calcium ion-dependent exocytosis (GO:0017156)4.86883061
29regulation of skeletal muscle contraction (GO:0014819)4.77320416
30ventricular system development (GO:0021591)4.70563589
31cellular process involved in reproduction in multicellular organism (GO:0022412)4.58101187
32germ cell development (GO:0007281)4.49403382
33regulation of inclusion body assembly (GO:0090083)4.40796907
34mitotic cell cycle arrest (GO:0071850)4.30388082
35purinergic nucleotide receptor signaling pathway (GO:0035590)4.28987675
36detection of molecule of bacterial origin (GO:0032490)4.24398689
37regulation of microtubule-based movement (GO:0060632)4.23074183
38cell recognition (GO:0008037)4.22967860
39male meiosis I (GO:0007141)3.99093439
40multicellular organismal reproductive process (GO:0048609)3.97287756
41regulation of cytokine production involved in inflammatory response (GO:1900015)3.79800817
42G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.77502709
43adenosine receptor signaling pathway (GO:0001973)3.77350218
44DNA methylation involved in gamete generation (GO:0043046)3.72215218
45seminiferous tubule development (GO:0072520)3.70877135
46left/right pattern formation (GO:0060972)3.69731566
47positive regulation of heat generation (GO:0031652)3.62076962
48glycerol ether metabolic process (GO:0006662)3.59966070
49protein polyglutamylation (GO:0018095)3.59672217
50chromosome organization involved in meiosis (GO:0070192)3.59012649
51spermatid nucleus differentiation (GO:0007289)3.58874457
52natural killer cell mediated cytotoxicity (GO:0042267)3.57691179
53natural killer cell mediated immunity (GO:0002228)3.57691179
54microtubule severing (GO:0051013)3.57347092
55sequestering of actin monomers (GO:0042989)3.55077854
56regulation of synapse structural plasticity (GO:0051823)3.49961804
57chromosome condensation (GO:0030261)3.47466756
58negative regulation of interleukin-12 production (GO:0032695)3.46654669
59response to ATP (GO:0033198)3.45896620
60negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.41856962
61myeloid cell activation involved in immune response (GO:0002275)3.40194958
62purinergic receptor signaling pathway (GO:0035587)3.39932468
63melanin biosynthetic process (GO:0042438)3.38970902
64positive regulation of gamma-delta T cell activation (GO:0046645)3.38838905
65positive regulation by symbiont of host defense response (GO:0052509)3.37614047
66modulation by symbiont of host defense response (GO:0052031)3.37614047
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.37614047
68modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.37614047
69positive regulation by organism of defense response of other organism involved in symbiotic interact3.37614047
70modulation by symbiont of host immune response (GO:0052553)3.37614047
71meiotic nuclear division (GO:0007126)3.36282156
72negative regulation of interleukin-8 production (GO:0032717)3.36172418
73protein localization to cilium (GO:0061512)3.35531269
74negative regulation of cell aging (GO:0090344)3.33913251
75detection of external biotic stimulus (GO:0098581)3.32003876
76DNA packaging (GO:0006323)3.31755943
77lens fiber cell differentiation (GO:0070306)3.29096928
78ether metabolic process (GO:0018904)3.28863394
79regulation of mast cell activation (GO:0033003)3.27156218
80negative regulation of cell killing (GO:0031342)3.21272725
81negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.21272725
82positive regulation of mast cell activation (GO:0033005)3.20710186
83multicellular organismal development (GO:0007275)3.20541730
84regulation of podosome assembly (GO:0071801)3.18953284
85macrophage activation (GO:0042116)3.15097522
86RNA destabilization (GO:0050779)3.14282981
87leukocyte degranulation (GO:0043299)3.13205565
88neutrophil activation (GO:0042119)3.12191159
89cellular extravasation (GO:0045123)3.11178640
90positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.09445824
91melanin metabolic process (GO:0006582)3.07353910
92regulation of heat generation (GO:0031650)3.06342793
93positive regulation of antigen processing and presentation (GO:0002579)3.06306555
94regulation of mast cell degranulation (GO:0043304)3.05584264
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.02715790
96regulation of mast cell activation involved in immune response (GO:0033006)3.00360897
97meiosis I (GO:0007127)2.99835759
98neutrophil activation involved in immune response (GO:0002283)2.99518574
99phosphatidylglycerol biosynthetic process (GO:0006655)2.98788735
100positive regulation of mast cell degranulation (GO:0043306)2.97918537
101positive regulation of mast cell activation involved in immune response (GO:0033008)2.97918537
102detection of other organism (GO:0098543)2.97400635
103interferon-gamma production (GO:0032609)2.96958807
104microglial cell activation (GO:0001774)2.96848084
105regulation of spindle checkpoint (GO:0090231)2.93218428
106secondary metabolite biosynthetic process (GO:0044550)2.92707876
107detection of biotic stimulus (GO:0009595)2.90914919
108immunoglobulin mediated immune response (GO:0016064)2.88873769
109NAD biosynthetic process (GO:0009435)2.87492544
110regulation of B cell receptor signaling pathway (GO:0050855)2.87478219
111leukocyte mediated cytotoxicity (GO:0001909)2.87153687
112meiotic cell cycle (GO:0051321)2.85491604
113behavioral response to nicotine (GO:0035095)2.80821164
114negative regulation of tumor necrosis factor production (GO:0032720)2.79302543
115mast cell activation (GO:0045576)2.78959659
116neutrophil mediated immunity (GO:0002446)2.77270126
117chaperone-mediated protein complex assembly (GO:0051131)2.77246926
118positive regulation of toll-like receptor signaling pathway (GO:0034123)2.75690391
119regulation of antigen processing and presentation (GO:0002577)2.72603626
120regulation of germinal center formation (GO:0002634)2.71895259
121mannose metabolic process (GO:0006013)2.70820895
122positive regulation of monocyte chemotaxis (GO:0090026)2.70711939
123antigen processing and presentation of endogenous antigen (GO:0019883)2.70586787
124negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.70385091
125membrane protein intracellular domain proteolysis (GO:0031293)2.70010553
126negative regulation of interleukin-1 beta production (GO:0032691)2.69829204
127detection of bacterium (GO:0016045)2.68831156
128protein K11-linked deubiquitination (GO:0035871)2.68665687
129cellular response to arsenic-containing substance (GO:0071243)2.68419368
130regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.67640946
131mast cell activation involved in immune response (GO:0002279)2.66581086
132mast cell degranulation (GO:0043303)2.66581086
133sexual reproduction (GO:0019953)2.66411374
134negative regulation of interleukin-1 production (GO:0032692)2.66330730
135regulation of interleukin-6 biosynthetic process (GO:0045408)2.65506598
136response to host immune response (GO:0052572)2.65097668
137response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.65097668
138positive regulation of interferon-alpha production (GO:0032727)2.64735249
139regulation of interferon-beta production (GO:0032648)2.64642944
140peptidyl-glutamic acid modification (GO:0018200)2.64252830
141nucleoside diphosphate phosphorylation (GO:0006165)2.63710782
142regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.63468805
143G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.63226762
144antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.62426301
145peptidyl-glutamic acid carboxylation (GO:0017187)2.61883871
146protein carboxylation (GO:0018214)2.61883871
147regulation of myeloid leukocyte mediated immunity (GO:0002886)2.61564906
148negative regulation of innate immune response (GO:0045824)2.61495383
149macrophage activation involved in immune response (GO:0002281)2.61257463
150sphingosine metabolic process (GO:0006670)2.60312835
151genitalia morphogenesis (GO:0035112)2.59165146
152regulation of toll-like receptor signaling pathway (GO:0034121)2.57645797
153polyol catabolic process (GO:0046174)2.55419004
154GDP-mannose metabolic process (GO:0019673)2.54869687
155response to peptidoglycan (GO:0032494)2.54384971
156positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54117845
157positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.53424044
158monoubiquitinated protein deubiquitination (GO:0035520)2.53276104
159single strand break repair (GO:0000012)2.53158418
160regulation of gamma-delta T cell activation (GO:0046643)2.53131826
161regulation of memory T cell differentiation (GO:0043380)2.50713774
162adaptation of signaling pathway (GO:0023058)2.50154651
163defense response to protozoan (GO:0042832)2.49785879
164nicotinamide nucleotide biosynthetic process (GO:0019359)2.49246823
165pyridine nucleotide biosynthetic process (GO:0019363)2.49246823
166regulation of interferon-alpha production (GO:0032647)2.49017323
167negative regulation of toll-like receptor signaling pathway (GO:0034122)2.46867153
168granulocyte differentiation (GO:0030851)2.45048141
169positive regulation of interleukin-1 beta secretion (GO:0050718)2.44487030
170protein refolding (GO:0042026)2.43695205
171polyamine biosynthetic process (GO:0006596)2.43108408
172glycolytic process (GO:0006096)2.41120424
173positive regulation of cellular amide metabolic process (GO:0034250)2.38768575
174positive regulation of chemokine biosynthetic process (GO:0045080)2.36564338
175cilium organization (GO:0044782)2.33621505
176microtubule polymerization or depolymerization (GO:0031109)2.32766678
177regulation of interferon-beta biosynthetic process (GO:0045357)2.31916008
178granulocyte activation (GO:0036230)2.31258695
179sperm motility (GO:0030317)12.0973931
180fusion of sperm to egg plasma membrane (GO:0007342)11.5498639
181acrosome reaction (GO:0007340)10.9439582
182cell wall macromolecule catabolic process (GO:0016998)10.6747618
183cell wall macromolecule metabolic process (GO:0044036)10.6747618
184multicellular organism reproduction (GO:0032504)10.0396018
185sperm-egg recognition (GO:0035036)10.0214133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.63597755
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.06665851
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.01484738
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.35716675
5VDR_21846776_ChIP-Seq_THP-1_Human3.30660252
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.86438234
7EZH2_22144423_ChIP-Seq_EOC_Human2.80258030
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.79049158
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.60929471
10VDR_24763502_ChIP-Seq_THP-1_Human2.53512783
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.47168670
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.46734415
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.39697864
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.33527881
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31630611
16PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.26350662
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.21676012
18MAF_26560356_Chip-Seq_TH2_Human2.19104141
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.14827808
20BCL6_27268052_Chip-Seq_Bcells_Human2.08644940
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03870068
22MAF_26560356_Chip-Seq_TH1_Human2.03398836
23P68_20966046_ChIP-Seq_HELA_Human2.00956658
24BCOR_27268052_Chip-Seq_Bcells_Human1.99866960
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.99850729
26E2F1_20622854_ChIP-Seq_HELA_Human1.98082841
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90795583
28VDR_22108803_ChIP-Seq_LS180_Human1.86063508
29PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.84330165
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82675855
31GATA1_26923725_Chip-Seq_HPCs_Mouse1.78249199
32SCL_19346495_ChIP-Seq_HPC-7_Human1.77765475
33EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.72894045
34UTX_26944678_Chip-Seq_JUKART_Human1.67938752
35LXR_22292898_ChIP-Seq_THP-1_Human1.66919164
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66581457
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61872118
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59818525
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57961955
40* STAT1_17558387_ChIP-Seq_HELA_Human1.57861779
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.57542151
42PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54907509
43SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.54704702
44TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.52862141
45* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50918177
46ELK4_26923725_Chip-Seq_MESODERM_Mouse1.50782621
47PHF8_20622854_ChIP-Seq_HELA_Human1.49295893
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49135943
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47554474
50CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.46574749
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45660888
52CTCF_20526341_ChIP-Seq_ESCs_Human1.44407725
53ERA_21632823_ChIP-Seq_H3396_Human1.43918161
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43568327
55VDR_24787735_ChIP-Seq_THP-1_Human1.40819235
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.40075988
57SPI1_23547873_ChIP-Seq_NB4_Human1.39619776
58EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38968760
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38368080
60RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.36658624
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36067502
62FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35117903
63CBP_20019798_ChIP-Seq_JUKART_Human1.34995229
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34995229
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.34862494
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.34440656
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.34228018
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33693710
69KDM2B_26808549_Chip-Seq_REH_Human1.33196279
70SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32969076
71RUNX_20019798_ChIP-Seq_JUKART_Human1.32363196
72* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30732459
73SOX2_22085726_ChIP-Seq_NPCs_Mouse1.29777919
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29772245
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29756409
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.29129962
77GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.28983689
78RXRA_24833708_ChIP-Seq_LIVER_Mouse1.27822633
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26624267
80GATA3_26560356_Chip-Seq_TH2_Human1.25178306
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25050418
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.24979654
83GATA3_21867929_ChIP-Seq_TH1_Mouse1.24798645
84TAF2_19829295_ChIP-Seq_ESCs_Human1.23812934
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23730171
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23573759
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23400734
88RARB_24833708_ChIP-Seq_LIVER_Mouse1.23363352
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21710865
90DROSHA_22980978_ChIP-Seq_HELA_Human1.20752697
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19734855
92EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19477706
93* NANOG_20526341_ChIP-Seq_ESCs_Human1.19055944
94LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.19023212
95GATA1_22025678_ChIP-Seq_K562_Human1.18938705
96SPI1_23127762_ChIP-Seq_K562_Human1.18561956
97* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.18207113
98P300_27268052_Chip-Seq_Bcells_Human1.16987867
99KAP1_22055183_ChIP-Seq_ESCs_Mouse1.16399916
100KDM2B_26808549_Chip-Seq_DND41_Human1.16340851
101CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16119037
102FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15545550
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15407079
104KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.15129271
105* OCT4_20526341_ChIP-Seq_ESCs_Human1.13837714
106* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13718471
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12726640
108CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12530167
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.12435911
110GATA3_21867929_ChIP-Seq_CD8_Mouse1.11967813
111NOTCH1_21737748_ChIP-Seq_TLL_Human1.11061904
112GF1_26923725_Chip-Seq_HPCs_Mouse1.10774713
113* SA1_27219007_Chip-Seq_Bcells_Human1.10702446
114GATA2_21666600_ChIP-Seq_HMVEC_Human1.10380091
115SMC4_20622854_ChIP-Seq_HELA_Human1.09923302
116* CTCF_27219007_Chip-Seq_Bcells_Human1.09765212
117TAF15_26573619_Chip-Seq_HEK293_Human1.09687837
118RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09247785
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07965648
120GATA1_19941827_ChIP-Seq_MEL_Mouse1.06765941
121IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06313019
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05888403
123* CTCF_21964334_Chip-Seq_Bcells_Human1.05833913
124SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05761996
125MYC_19829295_ChIP-Seq_ESCs_Human1.05493393
126PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05326371
127GATA3_27048872_Chip-Seq_THYMUS_Human1.04857239
128NFE2_27457419_Chip-Seq_LIVER_Mouse1.04480226
129PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03769750
130SPI1_20517297_ChIP-Seq_HL60_Human1.03768130
131EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03749016
132MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03351109
133* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03245346
134NANOG_18555785_Chip-Seq_ESCs_Mouse1.03006525
135PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02686983
136ZNF274_21170338_ChIP-Seq_K562_Hela1.01869365
137OCT4_19829295_ChIP-Seq_ESCs_Human1.01680426
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01635998
139CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01606307
140GATA1_19941826_ChIP-Seq_K562_Human1.01576722
141MYB_26560356_Chip-Seq_TH2_Human0.99976685
142VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99797687
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99725387
144RAC3_21632823_ChIP-Seq_H3396_Human0.99620511
145VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99275147
146CRX_20693478_ChIP-Seq_RETINA_Mouse0.98888762
147MYB_26560356_Chip-Seq_TH1_Human0.98809100
148BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98525322
149P53_22387025_ChIP-Seq_ESCs_Mouse0.98467552
150SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97698155
151RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97426167
152* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95462064
153SPI1_26923725_Chip-Seq_HPCs_Mouse0.94959398
154SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94113902
155JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93644999
156RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93106559
157SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.92188785
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92106055
159CMYC_18555785_Chip-Seq_ESCs_Mouse0.91634796
160PU1_27457419_Chip-Seq_LIVER_Mouse0.91183754
161CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91109414
162ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90541933
163RUNX1_26923725_Chip-Seq_HPCs_Mouse0.90282090
164EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90219724
165P53_21459846_ChIP-Seq_SAOS-2_Human0.89875055
166NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89856616
167OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89383751
168OCT4_18555785_Chip-Seq_ESCs_Mouse0.89338318
169P300_18555785_Chip-Seq_ESCs_Mouse0.88749848
170KLF4_18555785_Chip-Seq_ESCs_Mouse0.86407425
171PU_27001747_Chip-Seq_BMDM_Mouse0.85355864
172WDR5_24793694_ChIP-Seq_LNCAP_Human0.84893687
173PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84457121
174ESET_19884257_ChIP-Seq_ESCs_Mouse0.83907299

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation5.23801389
2MP0003698_abnormal_male_reproductive4.61042035
3MP0001929_abnormal_gametogenesis4.08350609
4MP0003011_delayed_dark_adaptation3.39607465
5MP0003136_yellow_coat_color3.38250225
6MP0005423_abnormal_somatic_nervous2.91032774
7MP0008877_abnormal_DNA_methylation2.79234423
8MP0001835_abnormal_antigen_presentation2.69038875
9MP0002161_abnormal_fertility/fecundity2.44658222
10MP0003436_decreased_susceptibility_to2.41414983
11MP0006082_CNS_inflammation2.38942959
12MP0003183_abnormal_peptide_metabolism2.38541638
13MP0002210_abnormal_sex_determination2.38030862
14MP0002419_abnormal_innate_immunity2.12451737
15MP0009785_altered_susceptibility_to2.10065545
16MP0004381_abnormal_hair_follicle2.03658871
17MP0002148_abnormal_hypersensitivity_rea2.02876539
18MP0001145_abnormal_male_reproductive2.00649643
19MP0005410_abnormal_fertilization13.5544484
20MP0005670_abnormal_white_adipose1.93971898
21MP0005000_abnormal_immune_tolerance1.93680230
22MP0008875_abnormal_xenobiotic_pharmacok1.91720293
23MP0005025_abnormal_response_to1.82112941
24MP0001968_abnormal_touch/_nociception1.75266512
25MP0003303_peritoneal_inflammation1.69690358
26MP0000653_abnormal_sex_gland1.67983619
27MP0003646_muscle_fatigue1.62140452
28MP0000569_abnormal_digit_pigmentation1.60361795
29MP0002452_abnormal_antigen_presenting1.60174745
30MP0003806_abnormal_nucleotide_metabolis1.57107715
31MP0002723_abnormal_immune_serum1.56971225
32MP0003724_increased_susceptibility_to1.53757829
33MP0002638_abnormal_pupillary_reflex1.53727681
34MP0004130_abnormal_muscle_cell1.48413051
35MP0005083_abnormal_biliary_tract1.46994524
36* MP0005551_abnormal_eye_electrophysiolog1.45521213
37MP0003195_calcinosis1.36680913
38MP0000372_irregular_coat_pigmentation1.35037009
39MP0002405_respiratory_system_inflammati1.33522087
40MP0002653_abnormal_ependyma_morphology1.33449530
41MP0009278_abnormal_bone_marrow1.31618863
42MP0003878_abnormal_ear_physiology1.30776890
43MP0005377_hearing/vestibular/ear_phenot1.30776890
44MP0001819_abnormal_immune_cell1.30304702
45MP0001756_abnormal_urination1.29845694
46MP0005167_abnormal_blood-brain_barrier1.28970718
47MP0002420_abnormal_adaptive_immunity1.28464696
48MP0003172_abnormal_lysosome_physiology1.28449585
49MP0001800_abnormal_humoral_immune1.26712303
50MP0008469_abnormal_protein_level1.20839065
51MP0005058_abnormal_lysosome_morphology1.20466497
52MP0000685_abnormal_immune_system1.20316920
53MP0001790_abnormal_immune_system1.19349072
54MP0005387_immune_system_phenotype1.19349072
55MP0003448_altered_tumor_morphology1.19323778
56MP0000604_amyloidosis1.16804256
57MP0004043_abnormal_pH_regulation1.15312260
58MP0004510_myositis1.14091995
59MP0001533_abnormal_skeleton_physiology1.13021463
60MP0005671_abnormal_response_to1.11444766
61MP0001502_abnormal_circadian_rhythm1.11202192
62MP0002736_abnormal_nociception_after1.10104417
63MP0005464_abnormal_platelet_physiology1.08902842
64MP0002735_abnormal_chemical_nociception1.08544613
65MP0005623_abnormal_meninges_morphology1.07807551
66MP0001853_heart_inflammation1.06789676
67MP0005409_darkened_coat_color1.06477474
68MP0001845_abnormal_inflammatory_respons1.05886858
69MP0003191_abnormal_cellular_cholesterol1.05323941
70MP0005075_abnormal_melanosome_morpholog1.04207073
71* MP0005253_abnormal_eye_physiology1.02099907
72MP0009764_decreased_sensitivity_to1.02049322
73MP0004019_abnormal_vitamin_homeostasis1.01572988
74MP0002095_abnormal_skin_pigmentation0.99599146
75MP0009046_muscle_twitch0.97170665
76MP0005397_hematopoietic_system_phenotyp0.95103098
77MP0001545_abnormal_hematopoietic_system0.95103098
78MP0002998_abnormal_bone_remodeling0.94596429
79MP0003075_altered_response_to0.94079301
80MP0002254_reproductive_system_inflammat0.92847078
81MP0000371_diluted_coat_color0.92684564
82MP0004947_skin_inflammation0.91825682
83MP0000343_altered_response_to0.91431442
84MP0001919_abnormal_reproductive_system0.90679337
85MP0002933_joint_inflammation0.88612387
86MP0001501_abnormal_sleep_pattern0.88020048
87* MP0001324_abnormal_eye_pigmentation0.87189782
88MP0003690_abnormal_glial_cell0.86971284
89MP0002160_abnormal_reproductive_system0.85310126
90MP0003656_abnormal_erythrocyte_physiolo0.84177160
91MP0001851_eye_inflammation0.83570701
92MP0002282_abnormal_trachea_morphology0.83318001
93MP0001188_hyperpigmentation0.82509061
94MP0000920_abnormal_myelination0.79989611
95MP0001970_abnormal_pain_threshold0.79283643
96MP0000716_abnormal_immune_system0.78839777
97MP0002163_abnormal_gland_morphology0.77036642
98MP0003453_abnormal_keratinocyte_physiol0.76790769
99MP0000750_abnormal_muscle_regeneration0.75295632
100MP0000470_abnormal_stomach_morphology0.75250711
101MP0005084_abnormal_gallbladder_morpholo0.74849768
102MP0002277_abnormal_respiratory_mucosa0.73962234
103MP0001661_extended_life_span0.72298002
104MP0005166_decreased_susceptibility_to0.71997924
105MP0003763_abnormal_thymus_physiology0.69114652
106MP0000249_abnormal_blood_vessel0.68797908
107MP0002398_abnormal_bone_marrow0.68033054
108MP0002075_abnormal_coat/hair_pigmentati0.66865778
109MP0005584_abnormal_enzyme/coenzyme_acti0.65746073
110MP0002006_tumorigenesis0.65483966
111MP0005332_abnormal_amino_acid0.65017184
112MP0003329_amyloid_beta_deposits0.64714833
113MP0010386_abnormal_urinary_bladder0.64593708
114MP0001765_abnormal_ion_homeostasis0.64180590
115MP0009115_abnormal_fat_cell0.63996801
116MP0010307_abnormal_tumor_latency0.61362422
117MP0005647_abnormal_sex_gland0.60550896
118MP0008260_abnormal_autophagy0.59099193
119MP0002295_abnormal_pulmonary_circulatio0.58883679
120MP0002429_abnormal_blood_cell0.58739440
121MP0010155_abnormal_intestine_physiology0.57547403
122MP0005174_abnormal_tail_pigmentation0.57035956
123MP0000689_abnormal_spleen_morphology0.56404120
124MP0000858_altered_metastatic_potential0.54826746
125MP0009840_abnormal_foam_cell0.53643120
126MP0003633_abnormal_nervous_system0.52545960
127MP0000358_abnormal_cell_content/0.52353830
128MP0005310_abnormal_salivary_gland0.50738334
129MP0003828_pulmonary_edema0.50500940
130MP0005164_abnormal_response_to0.48115546
131MP0009763_increased_sensitivity_to0.46773691
132MP0005319_abnormal_enzyme/_coenzyme0.46331393
133MP0004782_abnormal_surfactant_physiolog0.45933942
134MP0002332_abnormal_exercise_endurance0.43269767
135MP0005535_abnormal_body_temperature0.42838085
136MP0005390_skeleton_phenotype0.42529240
137MP0002722_abnormal_immune_system0.41883646
138MP0001873_stomach_inflammation0.41629772
139MP0004742_abnormal_vestibular_system0.41315374
140MP0004233_abnormal_muscle_weight0.41090237
141MP0003634_abnormal_glial_cell0.40727640
142MP0000015_abnormal_ear_pigmentation0.40182946
143MP0005257_abnormal_intraocular_pressure0.39846882
144MP0002971_abnormal_brown_adipose0.37927822
145MP0001986_abnormal_taste_sensitivity0.37781308
146MP0001293_anophthalmia0.37642150

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)7.90366931
2Abnormal respiratory motile cilium morphology (HP:0005938)7.90366931
3Abnormal respiratory motile cilium physiology (HP:0012261)7.79897484
4Rhinitis (HP:0012384)6.36888521
5Abnormal ciliary motility (HP:0012262)6.12476184
6Infertility (HP:0000789)6.06181540
7Nasal polyposis (HP:0100582)5.97397940
8Chronic bronchitis (HP:0004469)5.90461039
9Congenital stationary night blindness (HP:0007642)5.53051809
10Abnormality of the nasal mucosa (HP:0000433)4.97103188
11Mesangial abnormality (HP:0001966)4.68055955
12Bronchitis (HP:0012387)4.52514717
13* Attenuation of retinal blood vessels (HP:0007843)4.47197425
14Male infertility (HP:0003251)4.37161123
15Facial diplegia (HP:0001349)4.12955088
16Rib fusion (HP:0000902)4.06312459
17Testicular atrophy (HP:0000029)4.03950851
18J-shaped sella turcica (HP:0002680)3.92140006
19Recurrent abscess formation (HP:0002722)3.86106428
20Bronchiectasis (HP:0002110)3.85404273
21Bony spicule pigmentary retinopathy (HP:0007737)3.83156377
22Recurrent bacterial skin infections (HP:0005406)3.70775122
23Recurrent bronchitis (HP:0002837)3.60550503
24Recurrent gram-negative bacterial infections (HP:0005420)3.49478178
25Nephronophthisis (HP:0000090)3.48764314
26Joint hemorrhage (HP:0005261)3.41557293
27Poikiloderma (HP:0001029)3.33413770
28Abnormal spermatogenesis (HP:0008669)3.31177922
29Recurrent sinusitis (HP:0011108)3.29435729
30Recurrent otitis media (HP:0000403)3.19522913
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.15482407
32Akinesia (HP:0002304)3.09730069
33Annular pancreas (HP:0001734)3.08226593
34Deformed sella turcica (HP:0002681)3.06903413
35Rectovaginal fistula (HP:0000143)3.06568958
36Rectal fistula (HP:0100590)3.06568958
37Eczematoid dermatitis (HP:0000976)3.03407021
38Renal Fanconi syndrome (HP:0001994)2.95827090
39Chorioretinal atrophy (HP:0000533)2.94903401
40Premature graying of hair (HP:0002216)2.93729728
41Chronic mucocutaneous candidiasis (HP:0002728)2.91615721
42Recurrent cutaneous fungal infections (HP:0011370)2.91615721
43Intestinal fistula (HP:0100819)2.83749602
44* Decreased electroretinogram (ERG) amplitude (HP:0000654)2.82486448
45Lipid accumulation in hepatocytes (HP:0006561)2.78500497
46Retrobulbar optic neuritis (HP:0100654)2.76996158
47Optic neuritis (HP:0100653)2.76996158
48Hypoalbuminemia (HP:0003073)2.75252094
49Abnormal albumin level (HP:0012116)2.75252094
50Gastrointestinal infarctions (HP:0005244)2.74900955
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.71356611
52Abnormality of polysaccharide metabolism (HP:0011012)2.71356611
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.71356611
54Increased hepatocellular lipid droplets (HP:0006565)2.68756697
55Prolonged partial thromboplastin time (HP:0003645)2.67491577
56Vaginal fistula (HP:0004320)2.63142911
57Tubular atrophy (HP:0000092)2.62055241
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.61709469
59Keratoconjunctivitis (HP:0001096)2.59347595
60Abnormality of the renal medulla (HP:0100957)2.59149414
61Abnormality of the intrinsic pathway (HP:0010989)2.58311348
62Orchitis (HP:0100796)2.56602395
63Recurrent fungal infections (HP:0002841)2.52701055
64Thin bony cortex (HP:0002753)2.51867441
65Abnormality of the costochondral junction (HP:0000919)2.51504055
66Cheilitis (HP:0100825)2.44221852
67Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43374814
68Abnormality of glycolipid metabolism (HP:0010969)2.43303045
69Abnormality of liposaccharide metabolism (HP:0010968)2.43303045
70Abnormality of glycosphingolipid metabolism (HP:0004343)2.43303045
71Exertional dyspnea (HP:0002875)2.42775299
72Spastic tetraparesis (HP:0001285)2.40836820
73Urinary glycosaminoglycan excretion (HP:0003541)2.39728505
74Mucopolysacchariduria (HP:0008155)2.39728505
75Congenital sensorineural hearing impairment (HP:0008527)2.36794370
76Aplasia of the musculature (HP:0100854)2.32396946
77Hypophosphatemic rickets (HP:0004912)2.30775441
78Fetal akinesia sequence (HP:0001989)2.29964563
79Abnormal rod and cone electroretinograms (HP:0008323)2.28806620
80Enlarged epiphyses (HP:0010580)2.28062588
81Popliteal pterygium (HP:0009756)2.27653584
82Azoospermia (HP:0000027)2.26249610
83Anorexia (HP:0002039)2.25935946
84Tubulointerstitial abnormality (HP:0001969)2.25137683
85Tubulointerstitial nephritis (HP:0001970)2.24152266
86Myositis (HP:0100614)2.23677368
87Abnormality of the sella turcica (HP:0002679)2.22057921
88Ocular albinism (HP:0001107)2.21310326
89Hemoptysis (HP:0002105)2.21309918
90Mediastinal lymphadenopathy (HP:0100721)2.18834823
91Gonadotropin excess (HP:0000837)2.18510330
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15177539
93Disinhibition (HP:0000734)2.14475351
94Impulsivity (HP:0100710)2.14402789
95Dysostosis multiplex (HP:0000943)2.13440310
96Pustule (HP:0200039)2.12373343
97Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.11545941
98Neurofibrillary tangles (HP:0002185)2.08838853
99Abnormality of the common coagulation pathway (HP:0010990)2.08050893
100Loss of speech (HP:0002371)2.07897865
101Cholecystitis (HP:0001082)2.07712608
102Abnormal gallbladder physiology (HP:0012438)2.07712608
103Thick nail (HP:0001805)2.07285940
104Tubulointerstitial fibrosis (HP:0005576)2.06640853
105Epistaxis (HP:0000421)2.06469624
106Global brain atrophy (HP:0002283)2.05023105
107Medial flaring of the eyebrow (HP:0010747)2.04514884
108Atrioventricular block (HP:0001678)2.04489373
109* Decreased central vision (HP:0007663)2.04161473
110Recurrent skin infections (HP:0001581)2.02761773
111Short chin (HP:0000331)2.02715086
112Abnormality of renal resorption (HP:0011038)2.02394122
113Gingivitis (HP:0000230)2.01136714
114Dynein arm defect of respiratory motile cilia (HP:0012255)11.6844821
115Absent/shortened dynein arms (HP:0200106)11.6844821
116Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.1584089
117Episodic fever (HP:0001954)1.99919275
118Abnormal delayed hypersensitivity skin test (HP:0002963)1.97775016
119Molar tooth sign on MRI (HP:0002419)1.97759239
120Abnormality of midbrain morphology (HP:0002418)1.97759239
121Absent frontal sinuses (HP:0002688)1.97737175
122* Macular degeneration (HP:0000608)1.97240422
123Arterial thrombosis (HP:0004420)1.95461320
124Neonatal respiratory distress (HP:0002643)1.93003481
125Squamous cell carcinoma (HP:0002860)1.92225542
126Hypochromic anemia (HP:0001931)1.90350262
127Increased muscle lipid content (HP:0009058)1.90138659
128Abnormality of macrophages (HP:0004311)1.90090960
129Widely patent fontanelles and sutures (HP:0004492)1.89810802
130Facial hemangioma (HP:0000329)1.89553811
131Patellar aplasia (HP:0006443)1.88784561
132Petechiae (HP:0000967)1.87715609
133Encephalitis (HP:0002383)1.87499784
134Abolished electroretinogram (ERG) (HP:0000550)1.84659157
135Iris hypopigmentation (HP:0007730)1.83153418
136Genetic anticipation (HP:0003743)1.83030472
137Increased intramyocellular lipid droplets (HP:0012240)1.82778820
138Autoimmune thrombocytopenia (HP:0001973)1.79025292
139Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.77705493
140Stomatitis (HP:0010280)1.74343963
141Upper motor neuron abnormality (HP:0002127)1.71361968
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70771686
143Heterotopia (HP:0002282)1.69883542
144Increased CSF protein (HP:0002922)1.66178810
145Impaired proprioception (HP:0010831)1.65215554
146Elevated erythrocyte sedimentation rate (HP:0003565)1.64235344
147Tetraparesis (HP:0002273)1.63810999
148Cerebral inclusion bodies (HP:0100314)1.63432242
149Recurrent pneumonia (HP:0006532)1.62947829
150Hemiparesis (HP:0001269)1.57824648
151Axonal loss (HP:0003447)1.55975047
152Congenital hepatic fibrosis (HP:0002612)1.55730919
153Asymmetric septal hypertrophy (HP:0001670)1.55144644
154Prostate neoplasm (HP:0100787)1.53629420
155Abnormality of the frontal sinuses (HP:0002687)1.52720298
156Abnormal biliary tract physiology (HP:0012439)1.52025492
157Bile duct proliferation (HP:0001408)1.52025492
158Abnormal drinking behavior (HP:0030082)1.51974430
159Polydipsia (HP:0001959)1.51974430
160Systemic lupus erythematosus (HP:0002725)1.51608208
161Chronic obstructive pulmonary disease (HP:0006510)1.51090079
162Obstructive lung disease (HP:0006536)1.51090079
163Neuronal loss in central nervous system (HP:0002529)1.49862832
164Retinal atrophy (HP:0001105)1.47920677
165Oculomotor apraxia (HP:0000657)1.46521404
166Stage 5 chronic kidney disease (HP:0003774)1.44768048
167Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.42614696
168Nephropathy (HP:0000112)1.42294637
169Keratoconjunctivitis sicca (HP:0001097)1.42244604
170Supranuclear gaze palsy (HP:0000605)1.38425585
171Short ribs (HP:0000773)1.38277815
172Increased cerebral lipofuscin (HP:0011813)1.36274360
173Periodontitis (HP:0000704)1.35205682
174Personality changes (HP:0000751)1.32322350
175Osteolytic defects of the hand bones (HP:0009699)1.31979398
176Osteolytic defects of the phalanges of the hand (HP:0009771)1.31979398
177Abnormality of renal excretion (HP:0011036)1.31597809
178Postaxial foot polydactyly (HP:0001830)1.31028058
179Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.27558395
180Absent epiphyses (HP:0010577)1.27558395

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.85606400
2PDK36.85606400
3TESK15.96852281
4PDK25.32935438
5PRKD34.66771279
6ICK4.11886541
7RIPK43.39218577
8FRK2.86491160
9PTK2B2.59716035
10ACVR1B2.43064067
11ADRBK22.24459047
12TLK12.15487357
13GRK62.10598669
14TAOK32.07177891
15PNCK1.84254009
16MAP2K31.82069908
17STK391.59739435
18TBK11.50193010
19MAP3K141.46057679
20WNK41.45869381
21ADRBK11.42515208
22BMPR1B1.33057016
23TNK21.30442919
24ZAK1.29831409
25STK381.27006324
26PDK11.25683939
27SIK21.25542549
28PBK1.22287070
29DYRK1B1.21928232
30MAP3K111.18298911
31MAP4K11.17179969
32NEK21.13640298
33MAP3K31.11758768
34CAMKK21.11586859
35MAP2K61.11577267
36ARAF1.03177740
37PRKD20.99861082
38MAP3K130.97319586
39BLK0.95871981
40KIT0.95560475
41CSF1R0.86870890
42CAMK1G0.84840408
43TESK20.83454537
44OXSR10.82945127
45PDPK10.82458001
46JAK20.80548427
47IKBKB0.77096446
48TXK0.76637808
49STK110.76542848
50BMPR20.76036731
51TYK20.74960005
52MAPK150.74070004
53IRAK40.73812760
54PRKD10.69803093
55IRAK10.69406808
56ERN10.68302429
57WNK10.67312977
58ITK0.65532551
59AKT30.63825382
60CDK120.61121950
61IKBKE0.60052287
62CLK10.59449877
63BMX0.58179235
64BCKDK0.57414742
65IRAK20.55402730
66MAPK120.55242803
67PRKCH0.54456143
68DYRK30.54378499
69SIK30.52486024
70MST40.52011442
71TGFBR20.51212363
72PIK3CG0.50820000
73FGR0.50434682
74EPHB10.49589275
75MAPK130.49418762
76CCNB10.49097525
77PIM10.48833084
78EEF2K0.47996801
79ZAP700.47771027
80CSK0.46772544
81HCK0.46716493
82RPS6KC10.44900267
83RPS6KL10.44900267
84PIM20.44678568
85TAOK10.44229086
86STK160.44164802
87SYK0.43129758
88MAPKAPK50.43108857
89PKN10.42927775
90STK100.42695773
91MAP2K40.41976554
92ABL10.41745631
93MARK20.41565345
94SGK20.41540129
95TGFBR10.41390141
96STK30.40073878
97MAPK70.39746174
98GRK70.39479811
99PRKCQ0.39477439
100YES10.38244855
101MUSK0.38023470
102HIPK20.37816339
103SGK4940.37567140
104SGK2230.37567140
105LCK0.36190370
106DAPK20.35698437
107MARK30.35485100
108TEC0.35130671
109LYN0.34774029
110JAK10.34080044
111MAP4K20.33031957
112PAK10.32762653
113MOS0.31490518
114EGFR0.30649006
115MAP3K90.29938006
116PDGFRB0.28170236
117CHUK0.28167836
118CAMKK10.27689460
119ABL20.24123994
120RPS6KA20.22129409
121MST1R0.20840905
122RPS6KB10.20297685
123BTK0.19839993
124MAP3K10.18823945
125* PRKCD0.18715963
126MATK0.18702949
127RPS6KA60.18321328
128BRAF0.17293664
129PRKCG0.17212147
130RPS6KA10.15986922
131PLK20.15925252
132TYRO30.14883012
133MAP3K50.14664750
134NTRK20.14030208
135FES0.13846503
136PRKCZ0.12746961
137NEK60.12648146
138PINK10.12309826
139GRK10.11416369
140EIF2AK20.11196277
141PAK40.10761568
142IRAK30.10673419
143TRPM70.10562672
144JAK30.10085100
145RPS6KA40.09535289
146ERBB30.09021017

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006044.08273376
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.61292640
3Legionellosis_Homo sapiens_hsa051342.98774932
4Fatty acid biosynthesis_Homo sapiens_hsa000612.71634639
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.62831570
6Graft-versus-host disease_Homo sapiens_hsa053322.53999314
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.48989900
8Rheumatoid arthritis_Homo sapiens_hsa053232.45088899
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.33225245
10Leishmaniasis_Homo sapiens_hsa051402.07645222
11Collecting duct acid secretion_Homo sapiens_hsa049662.02066121
12Carbohydrate digestion and absorption_Homo sapiens_hsa049731.95741698
13Osteoclast differentiation_Homo sapiens_hsa043801.91132484
14Salmonella infection_Homo sapiens_hsa051321.89460201
15Staphylococcus aureus infection_Homo sapiens_hsa051501.88791797
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.82833144
17Phagosome_Homo sapiens_hsa041451.82470258
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80294581
19Malaria_Homo sapiens_hsa051441.79247267
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.72496322
21Phototransduction_Homo sapiens_hsa047441.72206027
22Dorso-ventral axis formation_Homo sapiens_hsa043201.71396454
23Tuberculosis_Homo sapiens_hsa051521.69326611
24Autoimmune thyroid disease_Homo sapiens_hsa053201.68320005
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.67857354
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.66891292
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62818522
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.60834356
29Measles_Homo sapiens_hsa051621.60297568
30Type I diabetes mellitus_Homo sapiens_hsa049401.59463516
31Mineral absorption_Homo sapiens_hsa049781.59074383
32Influenza A_Homo sapiens_hsa051641.55719282
33Antigen processing and presentation_Homo sapiens_hsa046121.55457707
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54584747
35B cell receptor signaling pathway_Homo sapiens_hsa046621.49757628
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49489294
37Sulfur relay system_Homo sapiens_hsa041221.46229045
38Linoleic acid metabolism_Homo sapiens_hsa005911.44756109
39Sphingolipid metabolism_Homo sapiens_hsa006001.43309163
40Pertussis_Homo sapiens_hsa051331.41752331
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.34519331
42Primary immunodeficiency_Homo sapiens_hsa053401.30912022
43Asthma_Homo sapiens_hsa053101.30685790
44TNF signaling pathway_Homo sapiens_hsa046681.30625002
45Allograft rejection_Homo sapiens_hsa053301.29675436
46Lysosome_Homo sapiens_hsa041421.28605634
47Vitamin B6 metabolism_Homo sapiens_hsa007501.21015347
48Ether lipid metabolism_Homo sapiens_hsa005651.18073747
49Glucagon signaling pathway_Homo sapiens_hsa049221.14793109
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12081039
51Pyruvate metabolism_Homo sapiens_hsa006201.11472295
52African trypanosomiasis_Homo sapiens_hsa051431.09829852
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08161874
54Toxoplasmosis_Homo sapiens_hsa051451.07537345
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06590411
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04684805
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02354735
58Basal transcription factors_Homo sapiens_hsa030220.97994751
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.97460618
60Herpes simplex infection_Homo sapiens_hsa051680.94909133
61Nicotine addiction_Homo sapiens_hsa050330.94795621
62Nitrogen metabolism_Homo sapiens_hsa009100.93775188
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93681851
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.92558049
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92024110
66Morphine addiction_Homo sapiens_hsa050320.91675439
67Glycerolipid metabolism_Homo sapiens_hsa005610.90269960
68Synaptic vesicle cycle_Homo sapiens_hsa047210.89970271
69PPAR signaling pathway_Homo sapiens_hsa033200.88337265
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87061273
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86595061
72Other glycan degradation_Homo sapiens_hsa005110.85816066
73Ovarian steroidogenesis_Homo sapiens_hsa049130.83810660
74Pentose phosphate pathway_Homo sapiens_hsa000300.82124125
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80894438
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80807255
77Fructose and mannose metabolism_Homo sapiens_hsa000510.80263133
78Taste transduction_Homo sapiens_hsa047420.80083091
79Hematopoietic cell lineage_Homo sapiens_hsa046400.79462170
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78210342
81ABC transporters_Homo sapiens_hsa020100.77953236
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77376147
83Shigellosis_Homo sapiens_hsa051310.75839243
84Circadian rhythm_Homo sapiens_hsa047100.73637559
85Chemokine signaling pathway_Homo sapiens_hsa040620.70805038
86Renin secretion_Homo sapiens_hsa049240.69575575
87Type II diabetes mellitus_Homo sapiens_hsa049300.68877991
88Apoptosis_Homo sapiens_hsa042100.66449300
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66329398
90T cell receptor signaling pathway_Homo sapiens_hsa046600.65723383
91Calcium signaling pathway_Homo sapiens_hsa040200.63921659
92Platelet activation_Homo sapiens_hsa046110.63394974
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62451974
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61155371
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61146903
96VEGF signaling pathway_Homo sapiens_hsa043700.58236533
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57916825
98Oocyte meiosis_Homo sapiens_hsa041140.56317736
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.55496572
100Systemic lupus erythematosus_Homo sapiens_hsa053220.53849978
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53625746
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53624136
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.52040042
104Hepatitis B_Homo sapiens_hsa051610.51966578
105Amphetamine addiction_Homo sapiens_hsa050310.51856129
106Vibrio cholerae infection_Homo sapiens_hsa051100.50913596
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49846414
108Inositol phosphate metabolism_Homo sapiens_hsa005620.49109869
109Endocytosis_Homo sapiens_hsa041440.48307659
110Regulation of autophagy_Homo sapiens_hsa041400.48224835
111Selenocompound metabolism_Homo sapiens_hsa004500.47912987
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45300686
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44932598
114Renin-angiotensin system_Homo sapiens_hsa046140.44085220
115Viral myocarditis_Homo sapiens_hsa054160.43926945
116Estrogen signaling pathway_Homo sapiens_hsa049150.43767321
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.43288115
118Prion diseases_Homo sapiens_hsa050200.42725171
119Vitamin digestion and absorption_Homo sapiens_hsa049770.41844152
120Amoebiasis_Homo sapiens_hsa051460.40962634
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.40840349
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40751338
123mTOR signaling pathway_Homo sapiens_hsa041500.40074216
124Epstein-Barr virus infection_Homo sapiens_hsa051690.39185371
125Propanoate metabolism_Homo sapiens_hsa006400.38647425
126Cardiac muscle contraction_Homo sapiens_hsa042600.37940333
127HIF-1 signaling pathway_Homo sapiens_hsa040660.36728398
128Serotonergic synapse_Homo sapiens_hsa047260.36643805
129Arachidonic acid metabolism_Homo sapiens_hsa005900.36283610
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35516948
131Circadian entrainment_Homo sapiens_hsa047130.34853444
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34821735
133Olfactory transduction_Homo sapiens_hsa047400.34800063
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.34655798
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.34191439
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34179641
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33925954
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32586379
139Huntingtons disease_Homo sapiens_hsa050160.30816239
140Hepatitis C_Homo sapiens_hsa051600.28411574
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27030496
142Insulin resistance_Homo sapiens_hsa049310.25515655

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