BEST3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.81837265
2Golgi transport vesicle coating (GO:0048200)7.81837265
3endocrine pancreas development (GO:0031018)5.61004216
4COPII vesicle coating (GO:0048208)5.40069127
5regulation of type B pancreatic cell apoptotic process (GO:2000674)5.32810187
6peptide hormone processing (GO:0016486)5.19536526
7regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.14996865
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.08786522
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.01202392
10regulation of relaxation of muscle (GO:1901077)4.97265619
11sarcoplasmic reticulum calcium ion transport (GO:0070296)4.80253483
12glandular epithelial cell differentiation (GO:0002067)4.64906471
13protein retention in ER lumen (GO:0006621)4.60927222
14positive regulation of insulin secretion (GO:0032024)4.48576287
15urinary tract smooth muscle contraction (GO:0014848)4.45251700
16detection of calcium ion (GO:0005513)4.44266254
17protein maturation by protein folding (GO:0022417)4.34190261
18signal peptide processing (GO:0006465)4.31442575
19insulin secretion (GO:0030073)4.24873826
20sarcomere organization (GO:0045214)4.23772224
21postsynaptic membrane organization (GO:0001941)4.22005939
22neuronal action potential propagation (GO:0019227)4.18603956
23regulation of insulin secretion (GO:0050796)4.07650977
24response to inactivity (GO:0014854)4.05901437
25response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.99325330
26exocrine pancreas development (GO:0031017)3.96202200
27negative regulation of glycoprotein biosynthetic process (GO:0010561)3.89130722
28regulation of sarcomere organization (GO:0060297)3.84348027
29sequestering of metal ion (GO:0051238)3.73726006
30activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.71672845
31regulation of peptide hormone secretion (GO:0090276)3.70027918
32regulation of peptide secretion (GO:0002791)3.65083653
33positive regulation of peptide hormone secretion (GO:0090277)3.64519561
34nitric oxide mediated signal transduction (GO:0007263)3.59913044
35positive regulation of peptide secretion (GO:0002793)3.58422079
36vesicle coating (GO:0006901)3.56656079
37positive regulation of glycolytic process (GO:0045821)3.55209953
38negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.54579661
39retinal cone cell development (GO:0046549)3.51190385
40muscle filament sliding (GO:0030049)3.50299756
41actin-myosin filament sliding (GO:0033275)3.50299756
42regulation of cell communication by electrical coupling (GO:0010649)3.47956598
43negative regulation of insulin secretion (GO:0046676)3.47588529
44positive regulation of nuclease activity (GO:0032075)3.47356851
45myotube cell development (GO:0014904)3.46919480
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.46389426
47negative regulation of cAMP-mediated signaling (GO:0043951)3.44848736
48growth hormone secretion (GO:0030252)3.41971343
49cellular ketone body metabolic process (GO:0046950)3.40348096
50regulation of skeletal muscle contraction (GO:0014819)3.38419382
51skeletal muscle adaptation (GO:0043501)3.35888938
52regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.33066280
53negative regulation of protein localization to cell surface (GO:2000009)3.32995246
54detection of light stimulus involved in visual perception (GO:0050908)3.32816221
55detection of light stimulus involved in sensory perception (GO:0050962)3.32816221
56glandular epithelial cell development (GO:0002068)3.32250045
57detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.30837167
58pyrimidine ribonucleoside catabolic process (GO:0046133)3.29703332
59striated muscle contraction (GO:0006941)3.29405462
60membrane depolarization during action potential (GO:0086010)3.28776320
61response to pheromone (GO:0019236)3.28273265
62myofibril assembly (GO:0030239)3.25694508
63regulation of hormone secretion (GO:0046883)3.23724287
64skeletal muscle fiber development (GO:0048741)3.22686578
65intra-Golgi vesicle-mediated transport (GO:0006891)3.21851586
66peptide hormone secretion (GO:0030072)3.20567756
67regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.18605672
68actin filament-based movement (GO:0030048)3.16864342
69presynaptic membrane assembly (GO:0097105)3.16470814
70regulation of nuclease activity (GO:0032069)3.15718723
71positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.14185931
72positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.13865075
73cilium or flagellum-dependent cell motility (GO:0001539)3.13209331
74skeletal muscle tissue regeneration (GO:0043403)3.11585391
75pharyngeal system development (GO:0060037)3.10630610
76regulation of glucocorticoid secretion (GO:2000849)3.10072930
77peptide secretion (GO:0002790)3.10014168
78regulation of oxidative phosphorylation (GO:0002082)3.09646886
79actin-mediated cell contraction (GO:0070252)3.07738190
80dicarboxylic acid catabolic process (GO:0043649)3.07251086
81regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.06956828
82protein localization to Golgi apparatus (GO:0034067)3.06668000
83positive regulation of gastrulation (GO:2000543)3.06198875
84cardiac myofibril assembly (GO:0055003)3.06127853
85photoreceptor cell maintenance (GO:0045494)3.04426525
86endoplasmic reticulum unfolded protein response (GO:0030968)3.03069085
87ketone body metabolic process (GO:1902224)3.01707524
88cell communication by electrical coupling (GO:0010644)3.00991974
89neuronal action potential (GO:0019228)3.00139180
90GDP-mannose metabolic process (GO:0019673)2.99477914
91negative regulation of peptide hormone secretion (GO:0090278)2.98624419
92cellular response to unfolded protein (GO:0034620)2.97203710
93positive regulation of vesicle fusion (GO:0031340)2.97032303
94response to muscle activity (GO:0014850)2.95875285
95muscle fiber development (GO:0048747)2.95805780
96regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.94876554
97regulation of peptide transport (GO:0090087)2.94572784
98cellular response to glucagon stimulus (GO:0071377)2.93656223
99indolalkylamine metabolic process (GO:0006586)2.92868257
100skeletal muscle contraction (GO:0003009)2.92153342
101ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.91425193
102cellular response to topologically incorrect protein (GO:0035967)2.90144547
103ER overload response (GO:0006983)2.89056862
104negative regulation of glycoprotein metabolic process (GO:1903019)2.89042997
105epithelial cell fate commitment (GO:0072148)2.88561588
106positive regulation of hormone secretion (GO:0046887)2.88482564
107membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87631097
108G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86750727
109response to dietary excess (GO:0002021)2.86584998
110toxin metabolic process (GO:0009404)2.86340894
111regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.86133276
112negative regulation of peptide secretion (GO:0002792)2.86027942
113carbohydrate homeostasis (GO:0033500)2.84717301
114glucose homeostasis (GO:0042593)2.84717301
115embryonic retina morphogenesis in camera-type eye (GO:0060059)2.84222420
116ER-nucleus signaling pathway (GO:0006984)2.83223269
117synaptic transmission, cholinergic (GO:0007271)2.83213095
118primitive streak formation (GO:0090009)2.82508339
119positive regulation of cation channel activity (GO:2001259)2.81635173
120astrocyte differentiation (GO:0048708)2.80467752
121reflex (GO:0060004)2.80046453
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.78581468
123tricarboxylic acid metabolic process (GO:0072350)2.76642851
124establishment of protein localization to Golgi (GO:0072600)2.76528883
125regulation of energy homeostasis (GO:2000505)2.76332788
126striated muscle atrophy (GO:0014891)2.75306190
127regulation of glucokinase activity (GO:0033131)2.74714655
128regulation of hexokinase activity (GO:1903299)2.74714655
129neural tube formation (GO:0001841)2.74678698
130regulation of membrane repolarization (GO:0060306)2.74405010
131regulation of pigment cell differentiation (GO:0050932)2.72828267
132plasma membrane repair (GO:0001778)2.72720176
133type B pancreatic cell development (GO:0003323)2.72638894
134negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.72344023
135negative regulation of calcium ion transmembrane transport (GO:1903170)2.72344023
136L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72158672
137cornea development in camera-type eye (GO:0061303)2.71774586
138macroautophagy (GO:0016236)2.70614170
139auditory receptor cell stereocilium organization (GO:0060088)2.70423444
140lactate metabolic process (GO:0006089)2.70158499
141kynurenine metabolic process (GO:0070189)2.70092977
142response to caffeine (GO:0031000)2.70023572
143negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.69283417
144C4-dicarboxylate transport (GO:0015740)2.69086415
145regulation of striated muscle contraction (GO:0006942)2.69017222
146regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.68848729
147adenosine metabolic process (GO:0046085)2.68557659
148neuromuscular synaptic transmission (GO:0007274)2.68527331
149regulation of actin filament-based movement (GO:1903115)2.68328631
150tryptophan catabolic process (GO:0006569)2.67437347
151indole-containing compound catabolic process (GO:0042436)2.67437347
152indolalkylamine catabolic process (GO:0046218)2.67437347
153regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.66201754
154aspartate family amino acid catabolic process (GO:0009068)2.65224885
155behavioral response to nicotine (GO:0035095)2.64190029
156muscle contraction (GO:0006936)2.64056982
157behavioral response to ethanol (GO:0048149)2.63959274
158presynaptic membrane organization (GO:0097090)2.63348881
159positive regulation of developmental pigmentation (GO:0048087)2.61887805
160relaxation of cardiac muscle (GO:0055119)2.61574846
161actomyosin structure organization (GO:0031032)2.61128553
162regulation of cilium movement (GO:0003352)2.60396754
163positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.58864011
164cardiac muscle hypertrophy (GO:0003300)2.58098969
165striated muscle adaptation (GO:0014888)2.55989550
166DNA double-strand break processing (GO:0000729)2.53639585
167gamma-aminobutyric acid transport (GO:0015812)2.53240153
168tachykinin receptor signaling pathway (GO:0007217)2.52942683
169muscle system process (GO:0003012)2.52053725
170regulation of calcium ion transmembrane transport (GO:1903169)2.51844776
171regulation of calcium ion transmembrane transporter activity (GO:1901019)2.51844776
172muscle atrophy (GO:0014889)2.50750113
173protein K11-linked deubiquitination (GO:0035871)2.48808307
174relaxation of muscle (GO:0090075)2.48725004
175calcium ion import (GO:0070509)2.48126500
176regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.47809362
177cellular response to sterol (GO:0036315)2.47510476
178interkinetic nuclear migration (GO:0022027)2.45812021
179striated muscle hypertrophy (GO:0014897)2.44115887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.40294479
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.93961490
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.85433625
4PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.77258850
5DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.63469995
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53065366
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28699789
8VDR_22108803_ChIP-Seq_LS180_Human2.07574076
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.06249471
10TAF15_26573619_Chip-Seq_HEK293_Human2.03487128
11P300_19829295_ChIP-Seq_ESCs_Human1.99425886
12FUS_26573619_Chip-Seq_HEK293_Human1.99205628
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95097599
14ER_23166858_ChIP-Seq_MCF-7_Human1.90146120
15EZH2_22144423_ChIP-Seq_EOC_Human1.88700535
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86373739
17GBX2_23144817_ChIP-Seq_PC3_Human1.81429675
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80550870
19ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.79790939
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78520948
21OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.78195700
22* EZH2_27294783_Chip-Seq_ESCs_Mouse1.77629826
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71355386
24DROSHA_22980978_ChIP-Seq_HELA_Human1.67097942
25REST_21632747_ChIP-Seq_MESCs_Mouse1.65613691
26ZNF274_21170338_ChIP-Seq_K562_Hela1.64730840
27* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.64047599
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63233785
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62523001
30CBP_20019798_ChIP-Seq_JUKART_Human1.62523001
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.61099159
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60105290
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.60105290
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.59831883
35NR3C1_21868756_ChIP-Seq_MCF10A_Human1.58895339
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58217099
37AR_25329375_ChIP-Seq_VCAP_Human1.57859599
38EWS_26573619_Chip-Seq_HEK293_Human1.56381282
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.55410120
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52970940
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52833768
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.52747354
43TBX20_22080862_ChIP-Seq_HEART_Mouse1.51895025
44TBX20_22328084_ChIP-Seq_HEART_Mouse1.51895025
45AR_21572438_ChIP-Seq_LNCaP_Human1.51615839
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51211977
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50400611
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49379212
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.48926797
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.47937749
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.47338157
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45031305
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44885226
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40393931
55NANOG_19829295_ChIP-Seq_ESCs_Human1.40133404
56SOX2_19829295_ChIP-Seq_ESCs_Human1.40133404
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40034812
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39922734
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38596614
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.37009587
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35928642
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35832742
63SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35485503
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.33643252
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33207542
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.32490653
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.31629637
68* STAT3_23295773_ChIP-Seq_U87_Human1.31406835
69* SMAD4_21741376_ChIP-Seq_EPCs_Human1.30713213
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30215161
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.29298237
72* CRX_20693478_ChIP-Seq_RETINA_Mouse1.28353537
73CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.27823395
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26882746
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25418451
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25332945
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25194034
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25173934
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24755286
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.22440852
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21800656
82TP53_16413492_ChIP-PET_HCT116_Human1.21416617
83OCT4_21477851_ChIP-Seq_ESCs_Mouse1.21410427
84P53_22387025_ChIP-Seq_ESCs_Mouse1.20002711
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19889150
86RUNX2_22187159_ChIP-Seq_PCA_Human1.19231940
87MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.18997515
88SMAD4_21799915_ChIP-Seq_A2780_Human1.18689433
89* TCF4_22108803_ChIP-Seq_LS180_Human1.18620828
90CDX2_22108803_ChIP-Seq_LS180_Human1.18371925
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.17748927
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14881744
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13674872
94SMAD3_21741376_ChIP-Seq_HESCs_Human1.12806970
95* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12202588
96CTCF_27219007_Chip-Seq_Bcells_Human1.10947179
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10495522
98NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09140200
99KDM2B_26808549_Chip-Seq_REH_Human1.09082008
100* SOX2_21211035_ChIP-Seq_LN229_Gbm1.08825562
101STAT3_18555785_Chip-Seq_ESCs_Mouse1.08660303
102* FLI1_21867929_ChIP-Seq_TH2_Mouse1.08602568
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08029548
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07730527
105TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06970326
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06203444
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05463333
108P300_18555785_Chip-Seq_ESCs_Mouse1.05107124
109CBX2_27304074_Chip-Seq_ESCs_Mouse1.04061392
110REST_19997604_ChIP-ChIP_NEURONS_Mouse1.03478674
111EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03059472
112FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01215951
113AR_19668381_ChIP-Seq_PC3_Human1.00939550
114FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00789836
115SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00638700
116SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99637840
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98060426
118CMYC_18555785_Chip-Seq_ESCs_Mouse0.97739365
119E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96701549
120RNF2_27304074_Chip-Seq_ESCs_Mouse0.96581122
121GF1B_26923725_Chip-Seq_HPCs_Mouse0.96309465
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95780320
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95340537
124* TCF4_23295773_ChIP-Seq_U87_Human0.95198343
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95152541
126RARB_27405468_Chip-Seq_BRAIN_Mouse0.94860860
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94856563
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94736383
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94736383
130RNF2_27304074_Chip-Seq_NSC_Mouse0.93933749
131SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93545395
132GF1_26923725_Chip-Seq_HPCs_Mouse0.93132703
133TP53_22573176_ChIP-Seq_HFKS_Human0.92817594
134SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92791758
135CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92249165
136EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92047338
137ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91919585
138FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91750758
139YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91337187
140ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91015449
141LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89383282
142* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89374845
143* BCAT_22108803_ChIP-Seq_LS180_Human0.89278039
144* FOXA1_25552417_ChIP-Seq_VCAP_Human0.88247616
145DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86971205
146TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86902477
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85451698
148EED_16625203_ChIP-ChIP_MESCs_Mouse0.85120372
149SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85024284
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.84417788
151ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84147745
152GATA1_19941826_ChIP-Seq_K562_Human0.82997276
153CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82390665
154PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81773978
155SMAD3_21741376_ChIP-Seq_ESCs_Human0.80847803
156CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.80832159
157ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80642615
158OCT4_20526341_ChIP-Seq_ESCs_Human0.80034236
159ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.79849192
160AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79517339
161GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.78895994
162FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78577232
163NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78452385
164RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.78317056
165SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77498855
166FOXH1_21741376_ChIP-Seq_ESCs_Human0.76271474
167HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.76077298
168IGF1R_20145208_ChIP-Seq_DFB_Human0.75862510
169EZH2_18974828_ChIP-Seq_MESCs_Mouse0.75840776
170RNF2_18974828_ChIP-Seq_MESCs_Mouse0.75840776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.48825081
2MP0000013_abnormal_adipose_tissue3.81240444
3MP0002877_abnormal_melanocyte_morpholog3.58365126
4MP0003283_abnormal_digestive_organ3.41481230
5MP0010386_abnormal_urinary_bladder3.37166310
6MP0002909_abnormal_adrenal_gland3.32381564
7MP0004043_abnormal_pH_regulation3.31140103
8MP0000749_muscle_degeneration3.00241471
9MP0003183_abnormal_peptide_metabolism2.93098541
10MP0003195_calcinosis2.92092305
11MP0002693_abnormal_pancreas_physiology2.89355680
12MP0001944_abnormal_pancreas_morphology2.84528856
13MP0004145_abnormal_muscle_electrophysio2.79790364
14MP0000751_myopathy2.63942084
15MP0003646_muscle_fatigue2.63564966
16MP0006072_abnormal_retinal_apoptosis2.53988390
17MP0002638_abnormal_pupillary_reflex2.51776307
18MP0004036_abnormal_muscle_relaxation2.48151212
19MP0009780_abnormal_chondrocyte_physiolo2.42790908
20MP0005379_endocrine/exocrine_gland_phen2.27454479
21MP0005220_abnormal_exocrine_pancreas2.26986317
22MP0004215_abnormal_myocardial_fiber2.26058933
23MP0000003_abnormal_adipose_tissue2.15498718
24MP0004233_abnormal_muscle_weight2.13982147
25MP0002269_muscular_atrophy2.12355072
26MP0000678_abnormal_parathyroid_gland2.08168445
27MP0002078_abnormal_glucose_homeostasis2.04452610
28MP0002736_abnormal_nociception_after2.03873748
29MP0001968_abnormal_touch/_nociception2.02576927
30MP0000372_irregular_coat_pigmentation1.98288183
31MP0003950_abnormal_plasma_membrane1.96524602
32MP0006292_abnormal_olfactory_placode1.96444721
33MP0009046_muscle_twitch1.85359659
34MP0003122_maternal_imprinting1.85181635
35MP0002234_abnormal_pharynx_morphology1.81600755
36MP0002332_abnormal_exercise_endurance1.78727944
37MP0000747_muscle_weakness1.68281339
38MP0008961_abnormal_basal_metabolism1.64192439
39MP0000759_abnormal_skeletal_muscle1.60433736
40MP0004084_abnormal_cardiac_muscle1.59836755
41MP0001501_abnormal_sleep_pattern1.57547182
42MP0002106_abnormal_muscle_physiology1.56466353
43MP0005620_abnormal_muscle_contractility1.55376051
44MP0002102_abnormal_ear_morphology1.53695811
45MP0003136_yellow_coat_color1.52818479
46MP0005646_abnormal_pituitary_gland1.50347713
47MP0005257_abnormal_intraocular_pressure1.50309738
48MP0003880_abnormal_central_pattern1.49387327
49MP0004087_abnormal_muscle_fiber1.47938338
50MP0008877_abnormal_DNA_methylation1.45435332
51MP0002272_abnormal_nervous_system1.45280674
52MP0004270_analgesia1.43530028
53MP0001502_abnormal_circadian_rhythm1.42380288
54MP0004130_abnormal_muscle_cell1.41420620
55MP0005645_abnormal_hypothalamus_physiol1.40121737
56MP0009745_abnormal_behavioral_response1.35553370
57MP0004142_abnormal_muscle_tone1.34221179
58MP0005369_muscle_phenotype1.33964842
59MP0005670_abnormal_white_adipose1.33433405
60MP0005266_abnormal_metabolism1.33345052
61MP0002876_abnormal_thyroid_physiology1.32427781
62MP0002928_abnormal_bile_duct1.31957148
63MP0001486_abnormal_startle_reflex1.31210232
64MP0001986_abnormal_taste_sensitivity1.30819448
65MP0005375_adipose_tissue_phenotype1.29932493
66MP0005330_cardiomyopathy1.29275211
67MP0002972_abnormal_cardiac_muscle1.28865313
68MP0003879_abnormal_hair_cell1.26818226
69MP0004484_altered_response_of1.25247960
70MP0001485_abnormal_pinna_reflex1.25189448
71MP0001765_abnormal_ion_homeostasis1.25032151
72MP0008057_abnormal_DNA_replication1.24241919
73MP0002735_abnormal_chemical_nociception1.22451063
74MP0004147_increased_porphyrin_level1.21252302
75MP0008775_abnormal_heart_ventricle1.20442966
76MP0002733_abnormal_thermal_nociception1.19541970
77MP0005167_abnormal_blood-brain_barrier1.16666381
78MP0005551_abnormal_eye_electrophysiolog1.14582906
79MP0004085_abnormal_heartbeat1.13413422
80MP0005253_abnormal_eye_physiology1.12968959
81MP0003953_abnormal_hormone_level1.11724511
82MP0005423_abnormal_somatic_nervous1.09737804
83MP0001984_abnormal_olfaction1.09159244
84MP0001970_abnormal_pain_threshold1.08107125
85MP0002896_abnormal_bone_mineralization1.07984158
86MP0000569_abnormal_digit_pigmentation1.07429857
87MP0002822_catalepsy1.05803190
88MP0003045_fibrosis1.05580613
89MP0000230_abnormal_systemic_arterial1.04334063
90MP0000462_abnormal_digestive_system1.03256478
91MP0002067_abnormal_sensory_capabilities1.03193859
92MP0000750_abnormal_muscle_regeneration1.03081460
93MP0002064_seizures1.02593968
94MP0003959_abnormal_lean_body1.00073287
95MP0008872_abnormal_physiological_respon0.98844572
96MP0002090_abnormal_vision0.97871543
97MP0003635_abnormal_synaptic_transmissio0.97689650
98MP0005535_abnormal_body_temperature0.96803526
99MP0002971_abnormal_brown_adipose0.96752689
100MP0003787_abnormal_imprinting0.96056672
101MP0001756_abnormal_urination0.95462915
102MP0003890_abnormal_embryonic-extraembry0.93523323
103MP0003137_abnormal_impulse_conducting0.92319271
104MP0000427_abnormal_hair_cycle0.90356092
105MP0003868_abnormal_feces_composition0.89946985
106MP0000613_abnormal_salivary_gland0.88766109
107MP0006036_abnormal_mitochondrial_physio0.88687141
108MP0004924_abnormal_behavior0.86465823
109MP0005386_behavior/neurological_phenoty0.86465823
110MP0003698_abnormal_male_reproductive0.86303122
111MP0000733_abnormal_muscle_development0.85716816
112MP0004510_myositis0.82238901
113MP0002572_abnormal_emotion/affect_behav0.79124419
114MP0003119_abnormal_digestive_system0.79033884
115MP0000631_abnormal_neuroendocrine_gland0.78847996
116MP0009697_abnormal_copulation0.77770193
117MP0005666_abnormal_adipose_tissue0.77177377
118MP0009643_abnormal_urine_homeostasis0.77068604
119MP0005410_abnormal_fertilization0.77036453
120MP0000383_abnormal_hair_follicle0.76953478
121MP0002127_abnormal_cardiovascular_syste0.76755569
122MP0002557_abnormal_social/conspecific_i0.76739311
123MP0006276_abnormal_autonomic_nervous0.75517117
124MP0005187_abnormal_penis_morphology0.73951652
125MP0003633_abnormal_nervous_system0.72017723
126MP0008058_abnormal_DNA_repair0.70932569
127MP0005084_abnormal_gallbladder_morpholo0.70369368
128MP0010630_abnormal_cardiac_muscle0.70090755
129MP0001929_abnormal_gametogenesis0.69917818
130MP0005334_abnormal_fat_pad0.69178382
131MP0005365_abnormal_bile_salt0.69071550
132MP0005448_abnormal_energy_balance0.68565703
133MP0004885_abnormal_endolymph0.67379081
134MP0001270_distended_abdomen0.66267703
135MP0005452_abnormal_adipose_tissue0.64914208
136MP0005636_abnormal_mineral_homeostasis0.64671807
137MP0004264_abnormal_extraembryonic_tissu0.64486023
138MP0002734_abnormal_mechanical_nocicepti0.63472024
139MP0002184_abnormal_innervation0.63081681
140MP0002163_abnormal_gland_morphology0.62851981
141MP0002108_abnormal_muscle_morphology0.59731597
142MP0001661_extended_life_span0.59704740
143MP0002229_neurodegeneration0.59108524
144MP0003172_abnormal_lysosome_physiology0.57446954
145MP0005385_cardiovascular_system_phenoty0.56781858
146MP0001544_abnormal_cardiovascular_syste0.56781858
147MP0002970_abnormal_white_adipose0.56420984
148MP0001299_abnormal_eye_distance/0.55069671
149MP0009672_abnormal_birth_weight0.54833213
150MP0002138_abnormal_hepatobiliary_system0.54775305

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.51738665
2Hypoglycemic seizures (HP:0002173)6.62999979
3Hypoglycemic coma (HP:0001325)6.39119540
4Symptomatic seizures (HP:0011145)5.91547796
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.84978223
6Hyperglycemia (HP:0003074)5.33126597
7Insulin-resistant diabetes mellitus (HP:0000831)4.83407869
8Ketoacidosis (HP:0001993)4.54418752
9Exercise-induced myalgia (HP:0003738)4.50569323
10Myoglobinuria (HP:0002913)4.09832932
11Abnormality of calcium-phosphate metabolism (HP:0100530)3.98698596
12Large for gestational age (HP:0001520)3.88037093
13Abnormality of endocrine pancreas physiology (HP:0012093)3.83983969
14Abnormality of the pancreatic islet cells (HP:0006476)3.83983969
15Late onset (HP:0003584)3.83105387
16Calf muscle hypertrophy (HP:0008981)3.76385629
17Pancreatic islet-cell hyperplasia (HP:0004510)3.74303583
18Absent phalangeal crease (HP:0006109)3.68059237
19Muscle hypertrophy of the lower extremities (HP:0008968)3.67511346
20Aplasia/Hypoplasia of the fovea (HP:0008060)3.36761502
21Hypoplasia of the fovea (HP:0007750)3.36761502
22Sudden death (HP:0001699)3.27099567
23Hyperkalemia (HP:0002153)3.23020776
24Abnormal finger flexion creases (HP:0006143)3.19994801
25Abnormal pancreas size (HP:0012094)3.16191306
26Generalized aminoaciduria (HP:0002909)3.15046539
27Exercise-induced muscle cramps (HP:0003710)3.14419594
28Prolonged QT interval (HP:0001657)3.12809729
29Fetal akinesia sequence (HP:0001989)3.10438772
30Abnormality of the fovea (HP:0000493)3.06217810
31Hyperventilation (HP:0002883)3.01505591
32Insulin resistance (HP:0000855)2.89966354
33Ketosis (HP:0001946)2.89849249
34Rimmed vacuoles (HP:0003805)2.88743415
35Muscle fiber inclusion bodies (HP:0100299)2.86520093
36Hypokalemia (HP:0002900)2.81759816
37Decreased circulating renin level (HP:0003351)2.79090346
38Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.77498458
39Areflexia of lower limbs (HP:0002522)2.74321235
40Retinal atrophy (HP:0001105)2.72967084
41Gaze-evoked nystagmus (HP:0000640)2.71285626
42Muscle fiber splitting (HP:0003555)2.67825009
43Abnormality of the calf musculature (HP:0001430)2.66377865
44Asymmetric septal hypertrophy (HP:0001670)2.64430314
45Malignant hyperthermia (HP:0002047)2.61601573
46Frequent falls (HP:0002359)2.61453758
47Round ear (HP:0100830)2.58715373
48Myopathic facies (HP:0002058)2.56567053
49Long clavicles (HP:0000890)2.56109438
50Syncope (HP:0001279)2.54922562
51Abnormality of potassium homeostasis (HP:0011042)2.54262049
52Gout (HP:0001997)2.51334552
53Palpitations (HP:0001962)2.49621982
54Bundle branch block (HP:0011710)2.48590099
55Ventricular tachycardia (HP:0004756)2.46489092
56Hemiparesis (HP:0001269)2.44790566
57Osteomalacia (HP:0002749)2.41695414
58Facial diplegia (HP:0001349)2.40912203
59Atrial fibrillation (HP:0005110)2.38612844
60Congenital stationary night blindness (HP:0007642)2.35373915
61EEG with generalized epileptiform discharges (HP:0011198)2.35137701
62Nemaline bodies (HP:0003798)2.29617962
63Febrile seizures (HP:0002373)2.29435070
64Abnormality of the ischium (HP:0003174)2.28833229
65Pheochromocytoma (HP:0002666)2.27638459
66Pancreatic cysts (HP:0001737)2.27410318
67Clumsiness (HP:0002312)2.27156435
68Attenuation of retinal blood vessels (HP:0007843)2.26070564
69Abnormal EKG (HP:0003115)2.25099374
70Epileptiform EEG discharges (HP:0011182)2.24977432
71Agitation (HP:0000713)2.24762583
72Type 1 muscle fiber predominance (HP:0003803)2.24520615
73Hyporeflexia of lower limbs (HP:0002600)2.22426826
74Broad-based gait (HP:0002136)2.20744817
75Neck muscle weakness (HP:0000467)2.20557491
76Hypoplastic ischia (HP:0003175)2.18271196
77Absence seizures (HP:0002121)2.17601569
78Dialeptic seizures (HP:0011146)2.16291086
79EMG: myopathic abnormalities (HP:0003458)2.14217566
80Primary atrial arrhythmia (HP:0001692)2.13590100
81Thyroid-stimulating hormone excess (HP:0002925)2.11543466
82Abnormality of the left ventricular outflow tract (HP:0011103)2.11510107
83Subaortic stenosis (HP:0001682)2.11510107
84Fair hair (HP:0002286)2.10683574
85Right ventricular cardiomyopathy (HP:0011663)2.07852581
86Prominent metopic ridge (HP:0005487)2.07383700
87Abnormality of binocular vision (HP:0011514)2.06561729
88Diplopia (HP:0000651)2.06561729
89Abnormality of the renal cortex (HP:0011035)2.06009133
90Calcaneovalgus deformity (HP:0001848)2.05991902
91Ventricular fibrillation (HP:0001663)2.05133072
92Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.02817888
93Genetic anticipation (HP:0003743)2.02643599
94Pancreatic fibrosis (HP:0100732)2.02285382
95Nonprogressive disorder (HP:0003680)2.02111539
96Aplasia/Hypoplasia of the macula (HP:0008059)2.01812123
97Focal seizures (HP:0007359)2.00545134
98Type II lissencephaly (HP:0007260)1.99288863
99Supraventricular tachycardia (HP:0004755)1.98195861
100Absent speech (HP:0001344)1.98101619
101Aplasia/Hypoplasia affecting the retina (HP:0008061)1.97043886
102Type 2 muscle fiber atrophy (HP:0003554)1.96951124
103Medial flaring of the eyebrow (HP:0010747)1.96565146
104Cerebellar dysplasia (HP:0007033)1.96317181
105Weak cry (HP:0001612)1.95571343
106Aplasia/Hypoplasia of the tibia (HP:0005772)1.95173126
107Distal arthrogryposis (HP:0005684)1.94813993
108Chronic hepatic failure (HP:0100626)1.93808494
109Fatigable weakness (HP:0003473)1.93165861
110Abnormality of the neuromuscular junction (HP:0003398)1.93165861
111Visual hallucinations (HP:0002367)1.92455186
112Dilated cardiomyopathy (HP:0001644)1.92440643
113Hyperphosphatemia (HP:0002905)1.92113894
114Neuroendocrine neoplasm (HP:0100634)1.92017023
115Supraventricular arrhythmia (HP:0005115)1.92009302
116Hypsarrhythmia (HP:0002521)1.91443113
117Generalized tonic-clonic seizures (HP:0002069)1.91362528
118True hermaphroditism (HP:0010459)1.91076216
119Difficulty running (HP:0009046)1.88544997
120Deformed tarsal bones (HP:0008119)1.87770182
121Myotonia (HP:0002486)1.86182090
122Neoplasm of the adrenal gland (HP:0100631)1.85610347
123Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84885397
124Abnormality of polysaccharide metabolism (HP:0011012)1.84885397
125Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84885397
126Rhabdomyolysis (HP:0003201)1.84582765
127Limb hypertonia (HP:0002509)1.84243376
128Focal motor seizures (HP:0011153)1.84109423
129Progressive cerebellar ataxia (HP:0002073)1.84019987
130EMG: neuropathic changes (HP:0003445)1.83456107
131Mucopolysacchariduria (HP:0008155)1.83328010
132Urinary glycosaminoglycan excretion (HP:0003541)1.83328010
133Abnormality of aromatic amino acid family metabolism (HP:0004338)1.83154614
134Inability to walk (HP:0002540)1.82982260
135Renal cortical cysts (HP:0000803)1.82841785
136Difficulty climbing stairs (HP:0003551)1.81669992
137Hyperparathyroidism (HP:0000843)1.80695915
138Popliteal pterygium (HP:0009756)1.79695029
139Hepatoblastoma (HP:0002884)1.79631115
140Congenital sensorineural hearing impairment (HP:0008527)1.79382072
141Central scotoma (HP:0000603)1.79015706
142Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78883391
143Abnormality of alanine metabolism (HP:0010916)1.78883391
144Hyperalaninemia (HP:0003348)1.78883391
145Dysostosis multiplex (HP:0000943)1.78787121
146Maternal diabetes (HP:0009800)1.78022949
147Abnormality of the intrinsic pathway (HP:0010989)1.77576746
148Protruding tongue (HP:0010808)1.77547648
149Abnormality of the metopic suture (HP:0005556)1.76374061
150Ulnar deviation of the wrist (HP:0003049)1.75158247
151Lipoatrophy (HP:0100578)1.74830548
152Hip contracture (HP:0003273)1.74166776
153Intestinal atresia (HP:0011100)1.73667505
154Progressive inability to walk (HP:0002505)1.73640247
155Left ventricular hypertrophy (HP:0001712)1.72835712
156Abnormality of renin-angiotensin system (HP:0000847)1.72158823
157Gait imbalance (HP:0002141)1.72123754
158Muscle stiffness (HP:0003552)1.71184529
159Generalized muscle weakness (HP:0003324)1.68577859
160Nephronophthisis (HP:0000090)1.68561688
161Methylmalonic aciduria (HP:0012120)1.68541009
162Bony spicule pigmentary retinopathy (HP:0007737)1.67574049
163Proximal amyotrophy (HP:0007126)1.66349805
164Atonic seizures (HP:0010819)1.65968207
165Polydipsia (HP:0001959)1.64731981
166Abnormal drinking behavior (HP:0030082)1.64731981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.94546614
2MAPK155.22459140
3WNK33.93153805
4PASK3.71692704
5PIK3CG2.91410112
6OBSCN2.70315188
7PRKD32.69557632
8PBK2.54618409
9HIPK22.45543900
10PHKG12.38129517
11PHKG22.38129517
12BMPR1B2.38040801
13ACVR1B2.19727432
14STK38L2.11984489
15MAP4K22.09132458
16ADRBK21.98941497
17FLT31.79134281
18MAPK131.77071213
19WNK41.76602405
20NME11.68287308
21TTN1.66841325
22PAK31.51613212
23CASK1.50589628
24EPHA31.48387666
25PINK11.43947633
26IRAK11.43881341
27IRAK31.42751382
28PDK21.40759027
29MKNK21.40029870
30GRK11.37820893
31ERN11.31897964
32CCNB11.22323517
33FER1.21926962
34UHMK11.19341804
35ZAK1.16085953
36BCKDK1.15401508
37MAP3K11.12407809
38MAP3K91.11260572
39MUSK1.06672156
40DYRK1B1.06023080
41PKN11.03918775
42CAMK2D1.02731612
43CDC42BPA1.01519431
44PNCK0.99211648
45PLK20.98683737
46PTK2B0.97963952
47PRKD20.96440227
48NEK10.95236586
49TAOK30.94652517
50AKT30.92548700
51MAPK120.91935282
52FGFR40.90226815
53STK30.90028294
54NTRK10.89351354
55PRKAA10.88862117
56IRAK20.87532749
57ADRBK10.86121600
58PAK60.85127517
59MAP2K70.83987719
60PDGFRA0.83601617
61PTK20.82640898
62SGK20.81661390
63MAP3K20.81057629
64VRK10.80217961
65DMPK0.78644077
66TNIK0.76573601
67PRKCH0.74416213
68CAMKK20.73440180
69SIK30.72887036
70SIK10.71723926
71BRSK20.71287715
72PLK40.69318250
73PRKCE0.68488873
74PTK60.68256713
75STK380.67623318
76FRK0.66132436
77OXSR10.64963642
78TEC0.63813541
79TRIB30.63290948
80PRKG10.63219506
81PRKCG0.62366233
82ERBB30.59363722
83TNK20.58048834
84NUAK10.58005496
85STK390.57735046
86CSNK1G10.56252070
87TRPM70.55697400
88RPS6KB10.55516668
89NTRK30.53892594
90CAMK1G0.51014597
91CAMK40.50308426
92WNK10.49681690
93STK160.49249104
94MAP2K40.47543020
95MAPK110.46346608
96TLK10.46170315
97PRKD10.46040793
98PRKAA20.45788688
99MARK20.45087441
100PIK3CA0.44404382
101RPS6KA50.43353348
102CSNK1D0.43347970
103EPHB10.42919153
104NLK0.42907522
105NTRK20.42657659
106ITK0.42126282
107MAP3K70.40815695
108SCYL20.40749126
109PDK30.40659578
110PDK40.40659578
111DAPK20.38938485
112CDK30.38637543
113PRKACB0.38460580
114KSR20.38383798
115TIE10.38327780
116CAMK2G0.37442649
117MKNK10.36522128
118TGFBR10.36509038
119SGK4940.36121457
120SGK2230.36121457
121CSNK1G20.34773849
122RET0.33926530
123LMTK20.33852539
124PRKACA0.33733335
125DYRK1A0.32637670
126SGK30.32483777
127ROCK10.32184615
128MARK30.31404285
129BRD40.31292225
130MET0.30916350
131EIF2AK30.30688914
132CSNK1G30.30187999
133RIPK10.29501263
134LATS10.29472881
135CSNK1A1L0.29179980
136BRAF0.28606482
137STK240.26159594
138ATM0.25947570
139MARK10.25901668
140CAMK1D0.25856454
141GSK3B0.25779539
142CAMK2A0.25691294
143PRKACG0.25679659
144MAP2K10.25514872
145CSNK1A10.25445080
146DYRK30.25056028
147SGK10.24842093
148CDC70.24405839
149MTOR0.23858936
150PRKCB0.23677871
151MAP3K50.23414004
152CAMK2B0.21073048
153PRKG20.20189251
154MAP2K20.19421592
155CAMK10.18975243
156JAK20.18574971
157PRKCA0.18272221
158MAP3K40.17668897
159MAPKAPK30.16752429
160CSK0.15933044
161RPS6KA30.15329464

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.21265083
2Protein export_Homo sapiens_hsa030604.27655573
3Insulin secretion_Homo sapiens_hsa049113.41959120
4Nitrogen metabolism_Homo sapiens_hsa009102.44314609
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.41772488
6Circadian rhythm_Homo sapiens_hsa047102.41695102
7Phototransduction_Homo sapiens_hsa047442.36143729
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.35465394
9Sulfur metabolism_Homo sapiens_hsa009202.33449197
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31356621
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29911254
12beta-Alanine metabolism_Homo sapiens_hsa004102.19133429
13Type II diabetes mellitus_Homo sapiens_hsa049302.15988208
14Vibrio cholerae infection_Homo sapiens_hsa051101.99318424
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.88625996
16Nicotine addiction_Homo sapiens_hsa050331.74683738
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.68462648
18Dilated cardiomyopathy_Homo sapiens_hsa054141.56689328
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.54881589
20Glucagon signaling pathway_Homo sapiens_hsa049221.54734379
21Fanconi anemia pathway_Homo sapiens_hsa034601.52158865
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51472335
23GABAergic synapse_Homo sapiens_hsa047271.45251370
24Cardiac muscle contraction_Homo sapiens_hsa042601.41752223
25Regulation of autophagy_Homo sapiens_hsa041401.36998226
26Cocaine addiction_Homo sapiens_hsa050301.30697919
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30063294
28Circadian entrainment_Homo sapiens_hsa047131.27410603
29Salivary secretion_Homo sapiens_hsa049701.26129093
30Homologous recombination_Homo sapiens_hsa034401.25107928
31Taste transduction_Homo sapiens_hsa047421.23638237
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21920404
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20067506
34Starch and sucrose metabolism_Homo sapiens_hsa005001.17776334
35Synaptic vesicle cycle_Homo sapiens_hsa047211.17536417
36Selenocompound metabolism_Homo sapiens_hsa004501.16501243
37Histidine metabolism_Homo sapiens_hsa003401.15406761
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15206069
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13273851
40Galactose metabolism_Homo sapiens_hsa000521.12290680
41Type I diabetes mellitus_Homo sapiens_hsa049401.10804582
42Glycerolipid metabolism_Homo sapiens_hsa005611.10429388
43Insulin resistance_Homo sapiens_hsa049311.07508060
44Morphine addiction_Homo sapiens_hsa050321.04265970
45N-Glycan biosynthesis_Homo sapiens_hsa005101.03959645
46Tryptophan metabolism_Homo sapiens_hsa003801.02896108
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02820306
48Lysosome_Homo sapiens_hsa041421.00051207
49Fatty acid biosynthesis_Homo sapiens_hsa000610.99663557
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.99158816
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98206331
52Serotonergic synapse_Homo sapiens_hsa047260.98022099
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97583889
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96361422
55Systemic lupus erythematosus_Homo sapiens_hsa053220.96159058
56Long-term depression_Homo sapiens_hsa047300.96035672
57Collecting duct acid secretion_Homo sapiens_hsa049660.95858480
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95587523
59Basal transcription factors_Homo sapiens_hsa030220.94589757
60Amphetamine addiction_Homo sapiens_hsa050310.92874227
61Butanoate metabolism_Homo sapiens_hsa006500.91828493
62Peroxisome_Homo sapiens_hsa041460.91698509
63Pancreatic secretion_Homo sapiens_hsa049720.90424711
64Fatty acid degradation_Homo sapiens_hsa000710.90405725
65Dopaminergic synapse_Homo sapiens_hsa047280.89462493
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89192221
67Cholinergic synapse_Homo sapiens_hsa047250.89098067
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84175536
69Non-homologous end-joining_Homo sapiens_hsa034500.84153440
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.83823478
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82518566
72Other glycan degradation_Homo sapiens_hsa005110.82254117
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.80145165
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79724314
75Dorso-ventral axis formation_Homo sapiens_hsa043200.79230892
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79106183
77Insulin signaling pathway_Homo sapiens_hsa049100.79007673
78Oxidative phosphorylation_Homo sapiens_hsa001900.78367567
79Ether lipid metabolism_Homo sapiens_hsa005650.75188414
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74790041
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74747511
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.74354029
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71402600
84One carbon pool by folate_Homo sapiens_hsa006700.71373966
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69825004
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69605055
87Linoleic acid metabolism_Homo sapiens_hsa005910.68345029
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.68004490
89ABC transporters_Homo sapiens_hsa020100.67820889
90Purine metabolism_Homo sapiens_hsa002300.66405248
91Renin secretion_Homo sapiens_hsa049240.64233960
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62737975
93Oxytocin signaling pathway_Homo sapiens_hsa049210.62364503
94Lysine degradation_Homo sapiens_hsa003100.61485287
95Sphingolipid metabolism_Homo sapiens_hsa006000.60982837
96Platelet activation_Homo sapiens_hsa046110.60517218
97Fructose and mannose metabolism_Homo sapiens_hsa000510.60184732
98Thyroid hormone synthesis_Homo sapiens_hsa049180.60074978
99Folate biosynthesis_Homo sapiens_hsa007900.59667942
100Retinol metabolism_Homo sapiens_hsa008300.57132190
101AMPK signaling pathway_Homo sapiens_hsa041520.55446944
102cAMP signaling pathway_Homo sapiens_hsa040240.54496874
103Phenylalanine metabolism_Homo sapiens_hsa003600.53906768
104Alzheimers disease_Homo sapiens_hsa050100.52690584
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50072973
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49397205
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49285361
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49023479
109Glutamatergic synapse_Homo sapiens_hsa047240.48919914
110Parkinsons disease_Homo sapiens_hsa050120.48887115
111Chemical carcinogenesis_Homo sapiens_hsa052040.48584138
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48070898
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47917981
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47458002
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47272168
116Prolactin signaling pathway_Homo sapiens_hsa049170.46891725
117Long-term potentiation_Homo sapiens_hsa047200.46406216
118Calcium signaling pathway_Homo sapiens_hsa040200.45551931
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44744039
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44206812
121Estrogen signaling pathway_Homo sapiens_hsa049150.44199812
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42148007
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.41078940
124Fatty acid elongation_Homo sapiens_hsa000620.38705151
125Fatty acid metabolism_Homo sapiens_hsa012120.38090634
126Olfactory transduction_Homo sapiens_hsa047400.37903938
127Prion diseases_Homo sapiens_hsa050200.37529653
128Arachidonic acid metabolism_Homo sapiens_hsa005900.37389786
129Oocyte meiosis_Homo sapiens_hsa041140.35644090
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.34894328
131FoxO signaling pathway_Homo sapiens_hsa040680.34678384
132GnRH signaling pathway_Homo sapiens_hsa049120.34188433
133Alcoholism_Homo sapiens_hsa050340.34111040
134Inositol phosphate metabolism_Homo sapiens_hsa005620.33822521
135Bile secretion_Homo sapiens_hsa049760.33582612
136Propanoate metabolism_Homo sapiens_hsa006400.33236910
137PPAR signaling pathway_Homo sapiens_hsa033200.33095991
138Arginine and proline metabolism_Homo sapiens_hsa003300.32458440
139Gastric acid secretion_Homo sapiens_hsa049710.31749502
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31300696
141Ovarian steroidogenesis_Homo sapiens_hsa049130.28887145
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28018821
143mTOR signaling pathway_Homo sapiens_hsa041500.27878734
144Pyruvate metabolism_Homo sapiens_hsa006200.26336837

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