BET1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.74720243
2central nervous system myelination (GO:0022010)6.74720243
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.52970701
4L-phenylalanine catabolic process (GO:0006559)6.52970701
5fatty acid elongation (GO:0030497)6.39662680
6signal peptide processing (GO:0006465)6.35059364
7L-phenylalanine metabolic process (GO:0006558)5.77833469
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.77833469
9DNA double-strand break processing (GO:0000729)4.86534309
10proteasome assembly (GO:0043248)4.83221839
11cholesterol biosynthetic process (GO:0006695)4.60014803
12nucleotide transmembrane transport (GO:1901679)4.54807521
13aromatic amino acid family catabolic process (GO:0009074)4.41137051
14platelet dense granule organization (GO:0060155)4.25668516
15respiratory chain complex IV assembly (GO:0008535)4.07069289
16sterol biosynthetic process (GO:0016126)4.05957839
17cullin deneddylation (GO:0010388)3.96674486
18amyloid precursor protein metabolic process (GO:0042982)3.94077781
19long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.86485602
20very long-chain fatty acid metabolic process (GO:0000038)3.83064723
21aldehyde catabolic process (GO:0046185)3.82707398
22positive regulation of cellular amine metabolic process (GO:0033240)3.80892305
23protein complex biogenesis (GO:0070271)3.73153757
24amyloid precursor protein catabolic process (GO:0042987)3.69732660
25fatty-acyl-CoA biosynthetic process (GO:0046949)3.68767378
26response to redox state (GO:0051775)3.58473435
27cytochrome complex assembly (GO:0017004)3.58009881
28fatty-acyl-CoA metabolic process (GO:0035337)3.53773984
29mitochondrial respiratory chain complex assembly (GO:0033108)3.53254026
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.52967237
31cofactor catabolic process (GO:0051187)3.52851553
32protein deneddylation (GO:0000338)3.51585745
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.51314881
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.51314881
35NADH dehydrogenase complex assembly (GO:0010257)3.51314881
36bile acid biosynthetic process (GO:0006699)3.51102456
37glyoxylate metabolic process (GO:0046487)3.49678547
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.45484259
39heme transport (GO:0015886)3.44822980
40tyrosine metabolic process (GO:0006570)3.42806242
41water-soluble vitamin biosynthetic process (GO:0042364)3.42667627
42myelination (GO:0042552)3.41046120
43coenzyme catabolic process (GO:0009109)3.40328550
44ensheathment of neurons (GO:0007272)3.38785022
45axon ensheathment (GO:0008366)3.38785022
46long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.38560421
47rRNA modification (GO:0000154)3.36228883
48GPI anchor biosynthetic process (GO:0006506)3.36098243
49pyrimidine-containing compound transmembrane transport (GO:0072531)3.32799925
50ER overload response (GO:0006983)3.32493969
51replication fork processing (GO:0031297)3.26960255
52CENP-A containing nucleosome assembly (GO:0034080)3.26811104
53regulation of lipoprotein metabolic process (GO:0050746)3.25379812
54thioester biosynthetic process (GO:0035384)3.24363238
55acyl-CoA biosynthetic process (GO:0071616)3.24363238
56L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.23564570
57nucleotide transport (GO:0006862)3.22136466
58DNA catabolic process, exonucleolytic (GO:0000738)3.22062410
59aromatic amino acid family metabolic process (GO:0009072)3.21334199
60chromatin remodeling at centromere (GO:0031055)3.20818341
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.20754896
62cysteine metabolic process (GO:0006534)3.20553694
63mannosylation (GO:0097502)3.14748050
64isoprenoid biosynthetic process (GO:0008299)3.14166196
65amino acid salvage (GO:0043102)3.13643797
66L-methionine salvage (GO:0071267)3.13643797
67L-methionine biosynthetic process (GO:0071265)3.13643797
68creatine metabolic process (GO:0006600)3.13300972
69establishment of protein localization to mitochondrial membrane (GO:0090151)3.13140329
70rRNA methylation (GO:0031167)3.13093700
71negative regulation of DNA-dependent DNA replication (GO:2000104)3.11807590
72protein neddylation (GO:0045116)3.11553540
73GPI anchor metabolic process (GO:0006505)3.11385330
74opsonization (GO:0008228)3.10753685
75protein carboxylation (GO:0018214)3.10037580
76peptidyl-glutamic acid carboxylation (GO:0017187)3.10037580
77DNA deamination (GO:0045006)3.06993091
78pseudouridine synthesis (GO:0001522)3.06418128
79detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05873309
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05644283
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01294416
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01294416
83bile acid metabolic process (GO:0008206)3.00727799
84double-strand break repair via homologous recombination (GO:0000724)3.00592275
85acyl-CoA metabolic process (GO:0006637)3.00261750
86thioester metabolic process (GO:0035383)3.00261750
87recombinational repair (GO:0000725)3.00154152
88L-serine metabolic process (GO:0006563)2.98297163
89myelin maintenance (GO:0043217)2.98029461
90peptidyl-histidine modification (GO:0018202)2.97558643
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.97345645
92indolalkylamine metabolic process (GO:0006586)2.97147134
93intestinal cholesterol absorption (GO:0030299)2.96456789
94termination of RNA polymerase III transcription (GO:0006386)2.96308939
95transcription elongation from RNA polymerase III promoter (GO:0006385)2.96308939
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94490772
97response to methylmercury (GO:0051597)2.93711235
98adenosine metabolic process (GO:0046085)2.91620871
99glutathione derivative metabolic process (GO:1901685)2.89826007
100glutathione derivative biosynthetic process (GO:1901687)2.89826007
101branched-chain amino acid catabolic process (GO:0009083)2.89695474
102RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.87511442
103histone mRNA metabolic process (GO:0008334)2.87424397
104protein K11-linked ubiquitination (GO:0070979)2.86963889
105long-chain fatty acid biosynthetic process (GO:0042759)2.86882347
106cellular ketone body metabolic process (GO:0046950)2.86634796
107tryptophan metabolic process (GO:0006568)2.85694622
108steroid biosynthetic process (GO:0006694)2.85403368
109positive regulation of lipoprotein lipase activity (GO:0051006)2.85374029
110positive regulation of triglyceride lipase activity (GO:0061365)2.85374029
111anterograde synaptic vesicle transport (GO:0048490)2.85131145
112lactate metabolic process (GO:0006089)2.83558858
113regulation of meiosis I (GO:0060631)2.80103131
114Golgi transport vesicle coating (GO:0048200)2.78153413
115COPI coating of Golgi vesicle (GO:0048205)2.78153413
116protein K6-linked ubiquitination (GO:0085020)2.77519899
117histone exchange (GO:0043486)2.77346198
118alpha-linolenic acid metabolic process (GO:0036109)2.76067503
119magnesium ion transport (GO:0015693)2.75677630
120cholesterol metabolic process (GO:0008203)2.75323183
121carbohydrate derivative transport (GO:1901264)2.74532733
122protein-cofactor linkage (GO:0018065)2.73998166
123tryptophan catabolic process (GO:0006569)2.73781549
124indole-containing compound catabolic process (GO:0042436)2.73781549
125indolalkylamine catabolic process (GO:0046218)2.73781549
126mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.73458825
127regulation of cholesterol metabolic process (GO:0090181)2.73020720
128chaperone-mediated protein transport (GO:0072321)2.72933921
129glycerophospholipid catabolic process (GO:0046475)2.71690443
130serine family amino acid biosynthetic process (GO:0009070)2.70701108
131regulation of mitotic spindle checkpoint (GO:1903504)2.70544800
132regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.70544800
133regulation of cellular amino acid metabolic process (GO:0006521)2.69844459
134protein maturation by protein folding (GO:0022417)2.69082223
135short-chain fatty acid metabolic process (GO:0046459)2.67726921
136negative regulation of neurotransmitter secretion (GO:0046929)2.67387172
137negative regulation of ligase activity (GO:0051352)2.67194876
138negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.67194876
139COPII vesicle coating (GO:0048208)2.67176869
140photoreceptor cell maintenance (GO:0045494)2.66722899
141ketone body metabolic process (GO:1902224)2.65129555
142prenylation (GO:0097354)2.64330953
143protein prenylation (GO:0018342)2.64330953
144kynurenine metabolic process (GO:0070189)2.63283281
145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.63166224
146xenobiotic catabolic process (GO:0042178)2.62403673
147peroxisome fission (GO:0016559)2.60909528
148tissue regeneration (GO:0042246)2.60841823
149energy coupled proton transport, down electrochemical gradient (GO:0015985)2.60716980
150ATP synthesis coupled proton transport (GO:0015986)2.60716980
151respiratory electron transport chain (GO:0022904)2.60186290
152preassembly of GPI anchor in ER membrane (GO:0016254)2.59445595
153dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.59345237
154protein localization to cilium (GO:0061512)2.58601277
155nonmotile primary cilium assembly (GO:0035058)2.58003879
156sterol metabolic process (GO:0016125)2.57767267
157sulfur amino acid catabolic process (GO:0000098)2.57682586
158drug transmembrane transport (GO:0006855)2.57638787
159regulation of metalloenzyme activity (GO:0048552)2.56361662
160positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.55807785
161cilium morphogenesis (GO:0060271)2.55340583
162ethanol oxidation (GO:0006069)2.54606572
163triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.54569964
164electron transport chain (GO:0022900)2.54486964
165maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.52140736
166purine nucleobase biosynthetic process (GO:0009113)2.52092116
167DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.52048464
168photoreceptor cell differentiation (GO:0046530)2.51878793
169eye photoreceptor cell differentiation (GO:0001754)2.51878793
170signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.51169772
171signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.51169772
172signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.51169772
173DNA replication checkpoint (GO:0000076)2.51087606
174regulation of mitochondrial translation (GO:0070129)2.50801418
175methionine biosynthetic process (GO:0009086)2.50179991
176C-terminal protein lipidation (GO:0006501)2.49933462
177maturation of 5.8S rRNA (GO:0000460)2.49580208
178somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.49204242
179isotype switching (GO:0045190)2.49204242
180somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.49204242
181response to nitrosative stress (GO:0051409)2.46418037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.15707454
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.20460217
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.02643625
4CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.56856286
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.48545535
6CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.25415531
7* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19911651
8* PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.14472864
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.11176379
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.05975643
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92871706
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.87776715
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.65925292
14* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.64438697
15EWS_26573619_Chip-Seq_HEK293_Human2.51404974
16ZNF274_21170338_ChIP-Seq_K562_Hela2.45188808
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.41200379
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09834552
19P300_19829295_ChIP-Seq_ESCs_Human2.09398120
20IGF1R_20145208_ChIP-Seq_DFB_Human2.05645896
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02361123
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.00134517
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88858160
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84566143
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81009483
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76537885
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75424069
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.75168395
29* EST1_17652178_ChIP-ChIP_JURKAT_Human1.74083069
30HTT_18923047_ChIP-ChIP_STHdh_Human1.74058768
31TAF15_26573619_Chip-Seq_HEK293_Human1.72376151
32* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68683153
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67247928
34VDR_22108803_ChIP-Seq_LS180_Human1.65801472
35* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63202375
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62389069
37RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.62377011
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62181566
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59144513
40* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.58664272
41* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.58664272
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58630369
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58537948
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55606775
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54081627
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48983844
47* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47646391
48MYC_18940864_ChIP-ChIP_HL60_Human1.46908665
49FOXP3_21729870_ChIP-Seq_TREG_Human1.46590491
50* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46523503
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44956950
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.44849605
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41670386
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41182398
55GATA1_22025678_ChIP-Seq_K562_Human1.40604507
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39814532
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36486285
58IRF1_19129219_ChIP-ChIP_H3396_Human1.34018451
59* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33679705
60BCAT_22108803_ChIP-Seq_LS180_Human1.30067959
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29521913
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29145547
63FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.25771765
64* SMAD4_21799915_ChIP-Seq_A2780_Human1.24511689
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23460070
66TCF4_22108803_ChIP-Seq_LS180_Human1.23323768
67CDX2_22108803_ChIP-Seq_LS180_Human1.21052753
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20639552
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18949333
70TP53_22573176_ChIP-Seq_HFKS_Human1.18506190
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.18457800
72AR_25329375_ChIP-Seq_VCAP_Human1.17936631
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17461513
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.17386027
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.17119380
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17119380
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17032844
78CBP_20019798_ChIP-Seq_JUKART_Human1.17032844
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.16209661
80ELK1_19687146_ChIP-ChIP_HELA_Human1.15341044
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14946395
82* STAT3_23295773_ChIP-Seq_U87_Human1.13103100
83* SOX17_20123909_ChIP-Seq_XEN_Mouse1.10504682
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10501659
85* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10214236
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10157915
87P53_22387025_ChIP-Seq_ESCs_Mouse1.08615356
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08557201
89SOX2_19829295_ChIP-Seq_ESCs_Human1.08096776
90NANOG_19829295_ChIP-Seq_ESCs_Human1.08096776
91POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07760044
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.06209499
93AR_20517297_ChIP-Seq_VCAP_Human1.05971377
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.05675623
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05049362
96* ETS1_20019798_ChIP-Seq_JURKAT_Human1.03278997
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03148131
98SOX2_20726797_ChIP-Seq_SW620_Human1.03102903
99SALL4_22934838_ChIP-ChIP_CD34+_Human1.02593327
100* TCF4_23295773_ChIP-Seq_U87_Human1.01832186
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.01287436
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01282089
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.00252395
104FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99937862
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99587413
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99293099
107* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99264841
108* ER_23166858_ChIP-Seq_MCF-7_Human0.99183480
109EZH2_27294783_Chip-Seq_NPCs_Mouse0.99151901
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98705189
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98336613
112* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97633046
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97011778
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95729127
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.95296914
116CRX_20693478_ChIP-Seq_RETINA_Mouse0.93727598
117CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92687708
118ERG_20517297_ChIP-Seq_VCAP_Human0.91539297
119LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91468220
120PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90380659
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90087607
122* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89843634
123IRF8_22096565_ChIP-ChIP_GC-B_Human0.89362648
124STAT3_18555785_Chip-Seq_ESCs_Mouse0.89357008
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88471572
126SMAD1_18555785_Chip-Seq_ESCs_Mouse0.86971269
127KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86381222
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85836441
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85763972
130SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85361416
131FOXA1_21572438_ChIP-Seq_LNCaP_Human0.85355076
132* FOXA1_25552417_ChIP-Seq_VCAP_Human0.84720875
133RUNX1_27457419_Chip-Seq_LIVER_Mouse0.84590638
134GBX2_23144817_ChIP-Seq_PC3_Human0.83230616
135FUS_26573619_Chip-Seq_HEK293_Human0.82700561
136FLI1_27457419_Chip-Seq_LIVER_Mouse0.81989998
137* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.80922110
138ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80319581
139* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.79831534
140P300_18555785_Chip-Seq_ESCs_Mouse0.79602706
141EOMES_21245162_ChIP-Seq_HESCs_Human0.79476556
142* VDR_23849224_ChIP-Seq_CD4+_Human0.78917607
143ELK1_22589737_ChIP-Seq_MCF10A_Human0.78603160
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77619843
145CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77430725
146CBP_21632823_ChIP-Seq_H3396_Human0.77122639
147EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.76846889
148CMYC_18555785_Chip-Seq_ESCs_Mouse0.76319562
149SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.76277576
150* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.75826735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.09138576
2MP0003806_abnormal_nucleotide_metabolis4.92690300
3MP0005365_abnormal_bile_salt3.99774745
4MP0003195_calcinosis3.91928722
5MP0005360_urolithiasis3.87388314
6MP0005085_abnormal_gallbladder_physiolo3.71591086
7MP0000920_abnormal_myelination3.33357367
8MP0008875_abnormal_xenobiotic_pharmacok3.32801177
9MP0003950_abnormal_plasma_membrane2.77932266
10MP0008058_abnormal_DNA_repair2.74868854
11MP0001666_abnormal_nutrient_absorption2.70595438
12MP0005083_abnormal_biliary_tract2.68568406
13MP0004043_abnormal_pH_regulation2.46999618
14MP0005408_hypopigmentation2.35325720
15MP0002102_abnormal_ear_morphology2.28727342
16MP0002736_abnormal_nociception_after2.22527895
17MP0003890_abnormal_embryonic-extraembry2.16894071
18MP0003186_abnormal_redox_activity2.13018205
19MP0008877_abnormal_DNA_methylation2.12655900
20MP0005058_abnormal_lysosome_morphology2.08906404
21MP0005332_abnormal_amino_acid2.05125682
22MP0003690_abnormal_glial_cell2.04358735
23MP0006072_abnormal_retinal_apoptosis2.03765162
24MP0010094_abnormal_chromosome_stability2.02949081
25MP0005451_abnormal_body_composition1.92855965
26MP0009840_abnormal_foam_cell1.87790638
27MP0005220_abnormal_exocrine_pancreas1.83055673
28MP0005171_absent_coat_pigmentation1.81067451
29MP0005551_abnormal_eye_electrophysiolog1.80338475
30MP0005253_abnormal_eye_physiology1.78881516
31MP0001529_abnormal_vocalization1.78316485
32MP0003252_abnormal_bile_duct1.78271280
33MP0001984_abnormal_olfaction1.76178772
34MP0002837_dystrophic_cardiac_calcinosis1.74336010
35MP0004215_abnormal_myocardial_fiber1.74054322
36MP0003136_yellow_coat_color1.73637846
37MP0009697_abnormal_copulation1.72854112
38MP0004957_abnormal_blastocyst_morpholog1.72229850
39MP0002118_abnormal_lipid_homeostasis1.69329120
40MP0010329_abnormal_lipoprotein_level1.63365311
41MP0001905_abnormal_dopamine_level1.62716658
42MP0006292_abnormal_olfactory_placode1.62472697
43MP0001764_abnormal_homeostasis1.60269995
44MP0003656_abnormal_erythrocyte_physiolo1.58887117
45MP0008057_abnormal_DNA_replication1.57319709
46MP0003868_abnormal_feces_composition1.56161714
47MP0001968_abnormal_touch/_nociception1.53859014
48MP0008872_abnormal_physiological_respon1.53284176
49MP0004133_heterotaxia1.47971345
50MP0003191_abnormal_cellular_cholesterol1.45399719
51MP0000569_abnormal_digit_pigmentation1.44467035
52MP0004381_abnormal_hair_follicle1.44051079
53MP0003786_premature_aging1.43607567
54MP0006035_abnormal_mitochondrial_morpho1.43187161
55MP0004147_increased_porphyrin_level1.40291381
56MP0008004_abnormal_stomach_pH1.39036093
57MP0005379_endocrine/exocrine_gland_phen1.38535427
58MP0005636_abnormal_mineral_homeostasis1.32477982
59MP0005584_abnormal_enzyme/coenzyme_acti1.31459188
60MP0003183_abnormal_peptide_metabolism1.31443657
61MP0005187_abnormal_penis_morphology1.31123085
62MP0008932_abnormal_embryonic_tissue1.30911511
63MP0004142_abnormal_muscle_tone1.29421156
64MP0001986_abnormal_taste_sensitivity1.27225176
65MP0002090_abnormal_vision1.26655847
66MP0002254_reproductive_system_inflammat1.26287821
67MP0006036_abnormal_mitochondrial_physio1.25464889
68MP0001661_extended_life_span1.24489928
69MP0002638_abnormal_pupillary_reflex1.22887443
70MP0008260_abnormal_autophagy1.22047789
71MP0009643_abnormal_urine_homeostasis1.21886577
72MP0003937_abnormal_limbs/digits/tail_de1.21820952
73MP0001293_anophthalmia1.21541863
74MP0000427_abnormal_hair_cycle1.20683128
75MP0000462_abnormal_digestive_system1.16768618
76MP0006276_abnormal_autonomic_nervous1.16577435
77MP0003941_abnormal_skin_development1.16296920
78MP0003724_increased_susceptibility_to1.16244935
79MP0003693_abnormal_embryo_hatching1.15973904
80MP0003880_abnormal_central_pattern1.15372746
81MP0005084_abnormal_gallbladder_morpholo1.12023289
82MP0010386_abnormal_urinary_bladder1.11548702
83MP0004134_abnormal_chest_morphology1.10877152
84MP0000516_abnormal_urinary_system1.10431986
85MP0005367_renal/urinary_system_phenotyp1.10431986
86MP0000631_abnormal_neuroendocrine_gland1.09730138
87MP0002295_abnormal_pulmonary_circulatio1.09531752
88MP0009046_muscle_twitch1.09368649
89MP0000604_amyloidosis1.08037416
90MP0005395_other_phenotype1.06712700
91MP0008789_abnormal_olfactory_epithelium1.04274769
92MP0005174_abnormal_tail_pigmentation1.03710140
93MP0002693_abnormal_pancreas_physiology1.02470804
94MP0000372_irregular_coat_pigmentation1.01509676
95MP0003329_amyloid_beta_deposits1.01428434
96MP0000609_abnormal_liver_physiology1.01079078
97MP0002095_abnormal_skin_pigmentation1.00638794
98MP0006082_CNS_inflammation0.99441867
99MP0000013_abnormal_adipose_tissue0.99341901
100MP0000639_abnormal_adrenal_gland0.98217949
101MP0003634_abnormal_glial_cell0.97787535
102MP0000358_abnormal_cell_content/0.97599603
103MP0004782_abnormal_surfactant_physiolog0.95804252
104MP0008438_abnormal_cutaneous_collagen0.95007717
105MP0001944_abnormal_pancreas_morphology0.94635060
106MP0001929_abnormal_gametogenesis0.94106258
107MP0000653_abnormal_sex_gland0.94097124
108MP0005319_abnormal_enzyme/_coenzyme0.93221790
109MP0005410_abnormal_fertilization0.92966501
110MP0002132_abnormal_respiratory_system0.92815242
111MP0005646_abnormal_pituitary_gland0.92684309
112MP0002160_abnormal_reproductive_system0.91204215
113MP0005389_reproductive_system_phenotype0.90328451
114MP0002163_abnormal_gland_morphology0.90012440
115MP0001501_abnormal_sleep_pattern0.89504256
116MP0001542_abnormal_bone_strength0.88490839
117MP0003011_delayed_dark_adaptation0.88339751
118MP0003077_abnormal_cell_cycle0.88307614
119MP0000613_abnormal_salivary_gland0.88107546
120MP0008995_early_reproductive_senescence0.88003569
121MP0003119_abnormal_digestive_system0.87366783
122MP0009379_abnormal_foot_pigmentation0.86887347
123MP0002210_abnormal_sex_determination0.86882095
124MP0001485_abnormal_pinna_reflex0.85283463
125MP0008007_abnormal_cellular_replicative0.85051143
126MP0010678_abnormal_skin_adnexa0.83474028
127MP0003567_abnormal_fetal_cardiomyocyte0.83282887
128MP0008775_abnormal_heart_ventricle0.83267562
129MP0002229_neurodegeneration0.81309484
130MP0005464_abnormal_platelet_physiology0.81145593
131MP0002138_abnormal_hepatobiliary_system0.79860804
132MP0001879_abnormal_lymphatic_vessel0.79664923
133MP0002928_abnormal_bile_duct0.79566815
134MP0003718_maternal_effect0.79183191
135MP0001119_abnormal_female_reproductive0.78461159
136MP0000230_abnormal_systemic_arterial0.78293218
137MP0002078_abnormal_glucose_homeostasis0.78165927
138MP0010030_abnormal_orbit_morphology0.77454873
139MP0008469_abnormal_protein_level0.77163585
140MP0001324_abnormal_eye_pigmentation0.76885469
141MP0002876_abnormal_thyroid_physiology0.76136778
142MP0005409_darkened_coat_color0.76044490
143MP0003698_abnormal_male_reproductive0.74792047
144MP0001145_abnormal_male_reproductive0.74683934
145MP0009765_abnormal_xenobiotic_induced0.74482579
146MP0000383_abnormal_hair_follicle0.73668116
147MP0002233_abnormal_nose_morphology0.72687962
148MP0006054_spinal_hemorrhage0.71281924
149MP0000566_synostosis0.70084856
150MP0002938_white_spotting0.69867639
151MP0003959_abnormal_lean_body0.69460770
152MP0004019_abnormal_vitamin_homeostasis0.68544473
153MP0005535_abnormal_body_temperature0.67653208
154MP0005647_abnormal_sex_gland0.67456847
155MP0005376_homeostasis/metabolism_phenot0.67251671
156MP0009780_abnormal_chondrocyte_physiolo0.65836642
157MP0003632_abnormal_nervous_system0.64656428
158MP0005075_abnormal_melanosome_morpholog0.63618064
159MP0000465_gastrointestinal_hemorrhage0.63522955
160MP0001243_abnormal_dermal_layer0.63321799
161MP0009642_abnormal_blood_homeostasis0.61822992
162MP0002933_joint_inflammation0.60881519
163MP0009763_increased_sensitivity_to0.60632173
164MP0001346_abnormal_lacrimal_gland0.60367827
165MP0004742_abnormal_vestibular_system0.58865259
166MP0000647_abnormal_sebaceous_gland0.57685468
167MP0005164_abnormal_response_to0.57521029
168MP0001765_abnormal_ion_homeostasis0.57055670

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.09067311
2Intrahepatic cholestasis (HP:0001406)4.56707047
3Prolonged partial thromboplastin time (HP:0003645)3.79341104
4Pancreatic cysts (HP:0001737)3.78849345
5Hypoglycemic coma (HP:0001325)3.50297485
6Pancreatic fibrosis (HP:0100732)3.48528962
7Acute encephalopathy (HP:0006846)3.44558166
8Neurofibrillary tangles (HP:0002185)3.37977436
9Fat malabsorption (HP:0002630)3.35672245
10True hermaphroditism (HP:0010459)3.35608398
11Acute necrotizing encephalopathy (HP:0006965)3.31709197
12Medial flaring of the eyebrow (HP:0010747)3.25958098
13Conjugated hyperbilirubinemia (HP:0002908)3.18881730
14Steatorrhea (HP:0002570)3.18475037
15Abnormality of glycolysis (HP:0004366)3.12407303
16Increased serum pyruvate (HP:0003542)3.12407303
17Abnormality of the intrinsic pathway (HP:0010989)3.11290045
183-Methylglutaconic aciduria (HP:0003535)3.04972263
19Abnormality of midbrain morphology (HP:0002418)3.02538811
20Molar tooth sign on MRI (HP:0002419)3.02538811
21Hepatic necrosis (HP:0002605)3.01674362
22Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.01614003
23Renal Fanconi syndrome (HP:0001994)2.99098186
24Hyperlipoproteinemia (HP:0010980)2.98389265
25Xanthomatosis (HP:0000991)2.98214489
26Abnormality of alanine metabolism (HP:0010916)2.97743409
27Hyperalaninemia (HP:0003348)2.97743409
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.97743409
29Parakeratosis (HP:0001036)2.97347283
30Abnormal mitochondria in muscle tissue (HP:0008316)2.96929136
31Abnormality of methionine metabolism (HP:0010901)2.96068877
32Cerebral edema (HP:0002181)2.92651411
33Hypoglycemic seizures (HP:0002173)2.91843447
34Generalized aminoaciduria (HP:0002909)2.90216292
35Hypobetalipoproteinemia (HP:0003563)2.83640749
36Mitochondrial inheritance (HP:0001427)2.82992590
37Abnormality of the common coagulation pathway (HP:0010990)2.81771227
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.76850170
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.76850170
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.76530565
41Glycosuria (HP:0003076)2.75727575
42Abnormality of urine glucose concentration (HP:0011016)2.75727575
43Progressive macrocephaly (HP:0004481)2.75301720
44Abnormality of monocarboxylic acid metabolism (HP:0010996)2.75243285
45Deep venous thrombosis (HP:0002625)2.72197507
46Congenital primary aphakia (HP:0007707)2.70421445
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.70397385
48Hyperinsulinemic hypoglycemia (HP:0000825)2.69319379
49Spastic paraparesis (HP:0002313)2.69148974
50Hepatocellular necrosis (HP:0001404)2.66667963
51Leukodystrophy (HP:0002415)2.64573224
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.62018300
53Hepatosplenomegaly (HP:0001433)2.60153554
54Abnormality of fatty-acid metabolism (HP:0004359)2.58572803
55Vacuolated lymphocytes (HP:0001922)2.57802174
56Abnormality of the renal cortex (HP:0011035)2.54845267
57Gait imbalance (HP:0002141)2.54587396
58Nephrogenic diabetes insipidus (HP:0009806)2.50947166
59Nephronophthisis (HP:0000090)2.49387137
60Congenital, generalized hypertrichosis (HP:0004540)2.46326336
61Genital tract atresia (HP:0001827)2.44849368
62Congenital ichthyosiform erythroderma (HP:0007431)2.42132793
63Symptomatic seizures (HP:0011145)2.40398602
64Vaginal atresia (HP:0000148)2.38702043
65Abnormality of serum amino acid levels (HP:0003112)2.38519877
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.37190713
67Increased serum lactate (HP:0002151)2.36085590
68Progressive neurologic deterioration (HP:0002344)2.35502569
69Cerebral hemorrhage (HP:0001342)2.35298353
70Lipid accumulation in hepatocytes (HP:0006561)2.34174895
71Hyperglycinemia (HP:0002154)2.33671193
72Increased CSF lactate (HP:0002490)2.30447655
73Dicarboxylic aciduria (HP:0003215)2.29642232
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.29642232
75Ketosis (HP:0001946)2.29100696
76Joint hemorrhage (HP:0005261)2.25804632
77Renal cortical cysts (HP:0000803)2.25619133
78Patchy hypopigmentation of hair (HP:0011365)2.25498769
79Abnormality of the renal medulla (HP:0100957)2.24210092
80Exertional dyspnea (HP:0002875)2.23701265
81Opisthotonus (HP:0002179)2.21822833
82Hyperbilirubinemia (HP:0002904)2.19759912
83Pancreatic islet-cell hyperplasia (HP:0004510)2.19167817
84Bile duct proliferation (HP:0001408)2.19121735
85Abnormal biliary tract physiology (HP:0012439)2.19121735
86Increased hepatocellular lipid droplets (HP:0006565)2.19067818
87Abnormal tarsal ossification (HP:0008369)2.19008293
88Lethargy (HP:0001254)2.18975899
89Cerebral hypomyelination (HP:0006808)2.18210395
90Abolished electroretinogram (ERG) (HP:0000550)2.16967354
91Abnormality of endocrine pancreas physiology (HP:0012093)2.15876527
92Abnormality of the pancreatic islet cells (HP:0006476)2.15876527
93Intestinal atresia (HP:0011100)2.15427810
94Abnormality of vitamin B metabolism (HP:0004340)2.14298457
95Neuroendocrine neoplasm (HP:0100634)2.11782813
96Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11697432
97Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11697432
98Abnormal protein N-linked glycosylation (HP:0012347)2.11573653
99Abnormal protein glycosylation (HP:0012346)2.11573653
100Abnormal glycosylation (HP:0012345)2.11573653
101Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11573653
102Type I transferrin isoform profile (HP:0003642)2.11452367
103Retinal dysplasia (HP:0007973)2.11059356
104Hypothermia (HP:0002045)2.10832817
105Sclerocornea (HP:0000647)2.10526947
106Abnormality of renal resorption (HP:0011038)2.10523773
107Abnormality of chromosome stability (HP:0003220)2.10149939
108Progressive inability to walk (HP:0002505)2.08635145
109Aplasia/Hypoplasia of the tibia (HP:0005772)2.07274190
110Abnormality of the fovea (HP:0000493)2.05970422
111Abnormality of the labia minora (HP:0012880)2.05804182
112Aplasia/Hypoplasia of the fovea (HP:0008060)2.05317478
113Hypoplasia of the fovea (HP:0007750)2.05317478
114Aplasia/Hypoplasia of the uvula (HP:0010293)2.04401891
115Hypophosphatemic rickets (HP:0004912)2.03182943
116Abnormality of glycine metabolism (HP:0010895)2.02468950
117Abnormality of serine family amino acid metabolism (HP:0010894)2.02468950
118Colon cancer (HP:0003003)2.02451674
119Abnormality of the ileum (HP:0001549)2.02361543
120Pheochromocytoma (HP:0002666)2.02319075
121Meckel diverticulum (HP:0002245)2.00947155
122Brushfield spots (HP:0001088)1.98796927
123Male pseudohermaphroditism (HP:0000037)1.95497858
124Abnormality of the vitamin B12 metabolism (HP:0004341)1.94481702
125Attenuation of retinal blood vessels (HP:0007843)1.94378418
126Furrowed tongue (HP:0000221)1.93590539
127Cystic liver disease (HP:0006706)1.93266778
128White forelock (HP:0002211)1.91536562
129Abnormal gallbladder morphology (HP:0012437)1.91383216
130Cerebral inclusion bodies (HP:0100314)1.90856021
131Epiphyseal stippling (HP:0010655)1.90563806
132Abnormality of sulfur amino acid metabolism (HP:0004339)1.90464270
133Complement deficiency (HP:0004431)1.90263746
134Optic disc pallor (HP:0000543)1.89791115
135Sensory axonal neuropathy (HP:0003390)1.89116184
136Hyperammonemia (HP:0001987)1.88313119
137CNS demyelination (HP:0007305)1.87514827
138Hyperphosphaturia (HP:0003109)1.87366502
139Methylmalonic acidemia (HP:0002912)1.86700942
140Lactic acidosis (HP:0003128)1.85700025
141Postaxial foot polydactyly (HP:0001830)1.85150423
142Ketoacidosis (HP:0001993)1.84068843
143Prolonged neonatal jaundice (HP:0006579)1.83690957
144Anencephaly (HP:0002323)1.83524113
145Respiratory failure (HP:0002878)1.83196325
146Increased intramyocellular lipid droplets (HP:0012240)1.83165423
147Epidermoid cyst (HP:0200040)1.82685514
148Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80935397
149Pancreatitis (HP:0001733)1.80859570
150Congenital stationary night blindness (HP:0007642)1.80555637
151Reduced antithrombin III activity (HP:0001976)1.80065133
152Supernumerary spleens (HP:0009799)1.79581189
153Stenosis of the external auditory canal (HP:0000402)1.77785416
154Increased muscle lipid content (HP:0009058)1.77604287
155Bifid tongue (HP:0010297)1.76783163
156Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75512136
157Abnormal lung lobation (HP:0002101)1.75511570
158Methylmalonic aciduria (HP:0012120)1.75438664
159Median cleft lip (HP:0000161)1.75195610
160Central scotoma (HP:0000603)1.74478111
161Congenital hepatic fibrosis (HP:0002612)1.72573247
162Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72477461
163Tubular atrophy (HP:0000092)1.71533925
164Small hand (HP:0200055)1.71039425
165Abnormality of the anterior horn cell (HP:0006802)1.68920939
166Degeneration of anterior horn cells (HP:0002398)1.68920939
167Poor coordination (HP:0002370)1.68885164

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.52868770
2PBK3.45965832
3BCKDK3.28846316
4OXSR13.22008192
5TRIM282.82467941
6ACVR1B2.74281076
7WNK32.59898968
8MAPK152.56949708
9EPHB12.53478082
10EIF2AK32.44417934
11WNK42.44048387
12MST42.42045994
13MAPKAPK52.41224153
14MET2.29072586
15ZAK2.27718431
16BCR2.22950675
17MAP4K22.14150755
18CDK192.11786165
19MKNK22.10896452
20BMPR1B2.03780522
21STK161.90228777
22VRK21.82227462
23PLK31.81788658
24FGFR21.77547031
25INSRR1.73646075
26NEK11.68853211
27CSNK1G31.55979937
28LIMK11.54086974
29TESK21.53769106
30PKN11.47196177
31PLK21.46457180
32TNIK1.43617979
33SRPK11.42267014
34PIK3CG1.41367733
35NEK61.40674180
36IRAK11.40540866
37STK31.40528140
38STK38L1.40178111
39PLK41.39966287
40TAF11.36809547
41FRK1.36704561
42TAOK31.34371627
43CSNK1A1L1.33674187
44CSNK1G11.30941355
45WEE11.27987562
46CASK1.25938959
47ADRBK21.23989373
48ERBB31.23523696
49ERBB41.23450808
50BUB11.23271316
51VRK11.23004954
52MAP3K121.20235570
53MUSK1.13857953
54TGFBR11.11600372
55TTK1.10509480
56IRAK41.10154272
57CAMK2B1.05742226
58CAMK2D1.00750839
59IRAK21.00702476
60PDK20.99956876
61CLK10.98910806
62IRAK30.97561066
63PASK0.97024244
64DYRK20.96732378
65TEC0.90932514
66ABL20.90114383
67MAP3K40.89793842
68PINK10.87991959
69CAMK2G0.86471777
70CSNK1G20.85847301
71UHMK10.85170872
72GRK70.84599143
73NTRK10.84106202
74DYRK30.83778893
75CDC70.83242021
76STK240.82807375
77PLK10.81337112
78ARAF0.81208300
79TSSK60.78955829
80FER0.76838218
81NME20.76330441
82ADRBK10.75758982
83TLK10.75714538
84EIF2AK20.75329811
85MAPK130.74737918
86ERN10.74304374
87BMPR20.72581659
88NME10.71853995
89ITK0.71043936
90WNK10.70653468
91EIF2AK10.70020461
92BRSK20.67914585
93TIE10.66827313
94PRKCQ0.66443912
95PRKCE0.65479197
96MST1R0.64753215
97RPS6KA50.64446690
98NUAK10.63295127
99SGK2230.63102748
100SGK4940.63102748
101OBSCN0.61553410
102BTK0.60954102
103PTK2B0.58977747
104TRPM70.57372881
105HIPK20.56627820
106GSK3A0.52732164
107GRK10.52652708
108MAP3K140.52295042
109PRKCG0.51634012
110PRKG20.50044372
111PNCK0.49893176
112KDR0.47821913
113MAPKAPK30.46840244
114MKNK10.45094288
115MAP2K20.44034458
116AKT30.43646404
117ATR0.42639311
118BRAF0.42420633
119CAMK2A0.41971205
120TXK0.41558471
121MYLK0.41501905
122MAP3K20.40556353
123FLT30.40317437
124ATM0.39811062
125CSNK1A10.39176834
126CSNK2A10.38917247
127ROCK20.38760130
128CHEK20.38246178
129KIT0.37724380
130STK40.37161896
131NLK0.36610347
132GRK50.36484041
133LYN0.36262198
134PRKG10.35712411
135PRKACB0.35205112
136PIK3CA0.34590246
137IGF1R0.34577254
138LATS10.34112344
139PRKD10.31939130
140FGFR10.31397173
141PRKACA0.30315397
142CCNB10.30266332
143MAP2K70.30094827
144MAPK70.29834519
145NEK90.29834056
146STK100.29530503
147SIK30.29046662
148PAK30.28951059
149RPS6KA40.28684721
150ILK0.27807734
151BRSK10.27597151
152CSNK2A20.26381091
153AURKB0.24770176

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.77214537
2Fatty acid elongation_Homo sapiens_hsa000623.35460488
3Steroid biosynthesis_Homo sapiens_hsa001003.26670410
4Sulfur metabolism_Homo sapiens_hsa009203.10557864
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.73109341
6Homologous recombination_Homo sapiens_hsa034402.69763132
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.67908914
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53088652
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.49316570
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.48911620
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.38606746
12Histidine metabolism_Homo sapiens_hsa003402.29976366
13Folate biosynthesis_Homo sapiens_hsa007902.29904357
14Mismatch repair_Homo sapiens_hsa034302.20356894
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18694557
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.17510816
17Oxidative phosphorylation_Homo sapiens_hsa001902.08903651
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02811323
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97169254
20Peroxisome_Homo sapiens_hsa041461.90907506
21Fanconi anemia pathway_Homo sapiens_hsa034601.86416788
22Propanoate metabolism_Homo sapiens_hsa006401.80652806
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74021909
24Butanoate metabolism_Homo sapiens_hsa006501.72051591
25One carbon pool by folate_Homo sapiens_hsa006701.61295955
26Tryptophan metabolism_Homo sapiens_hsa003801.61271289
27RNA degradation_Homo sapiens_hsa030181.59365767
28Nitrogen metabolism_Homo sapiens_hsa009101.57872030
29Ether lipid metabolism_Homo sapiens_hsa005651.56027424
30Vitamin B6 metabolism_Homo sapiens_hsa007501.54570279
31Parkinsons disease_Homo sapiens_hsa050121.53212247
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.49873079
33Chemical carcinogenesis_Homo sapiens_hsa052041.48167446
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45140743
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44593325
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.39167176
37Fatty acid degradation_Homo sapiens_hsa000711.38934831
38Complement and coagulation cascades_Homo sapiens_hsa046101.34144706
39Nucleotide excision repair_Homo sapiens_hsa034201.32650851
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31058769
41Linoleic acid metabolism_Homo sapiens_hsa005911.29601459
42Phototransduction_Homo sapiens_hsa047441.29019001
43Fatty acid metabolism_Homo sapiens_hsa012121.28886439
44Glutathione metabolism_Homo sapiens_hsa004801.26618807
45Arginine and proline metabolism_Homo sapiens_hsa003301.26510617
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22853006
47Pyruvate metabolism_Homo sapiens_hsa006201.18186706
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17453811
49Alzheimers disease_Homo sapiens_hsa050101.13238539
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12360695
51Tyrosine metabolism_Homo sapiens_hsa003501.12166794
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11207282
53DNA replication_Homo sapiens_hsa030301.10340252
54Proteasome_Homo sapiens_hsa030501.09736350
55RNA transport_Homo sapiens_hsa030131.09552540
56Caffeine metabolism_Homo sapiens_hsa002321.09133841
57Retinol metabolism_Homo sapiens_hsa008301.08671988
58Selenocompound metabolism_Homo sapiens_hsa004501.05894258
59beta-Alanine metabolism_Homo sapiens_hsa004101.05854301
60Sphingolipid metabolism_Homo sapiens_hsa006001.01322083
61Drug metabolism - other enzymes_Homo sapiens_hsa009831.00760661
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99764579
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98334120
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93236558
65* SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91196285
66Metabolic pathways_Homo sapiens_hsa011000.89086676
67Vibrio cholerae infection_Homo sapiens_hsa051100.88057034
68Fat digestion and absorption_Homo sapiens_hsa049750.87317939
69Arachidonic acid metabolism_Homo sapiens_hsa005900.87222800
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87077215
71Vitamin digestion and absorption_Homo sapiens_hsa049770.81309794
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.78014401
73Huntingtons disease_Homo sapiens_hsa050160.77639112
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76041255
75Arginine biosynthesis_Homo sapiens_hsa002200.75536123
76PPAR signaling pathway_Homo sapiens_hsa033200.74402910
77Phenylalanine metabolism_Homo sapiens_hsa003600.74385410
78Base excision repair_Homo sapiens_hsa034100.72034950
79ABC transporters_Homo sapiens_hsa020100.71579190
80Lysosome_Homo sapiens_hsa041420.70758789
81Starch and sucrose metabolism_Homo sapiens_hsa005000.68146920
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66965802
83p53 signaling pathway_Homo sapiens_hsa041150.66645277
84Spliceosome_Homo sapiens_hsa030400.65140817
85RNA polymerase_Homo sapiens_hsa030200.64099997
86Sulfur relay system_Homo sapiens_hsa041220.63918539
87Regulation of autophagy_Homo sapiens_hsa041400.62877999
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61542516
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61307055
90Olfactory transduction_Homo sapiens_hsa047400.61054997
91Staphylococcus aureus infection_Homo sapiens_hsa051500.59204937
92N-Glycan biosynthesis_Homo sapiens_hsa005100.58986574
93Ribosome_Homo sapiens_hsa030100.56679206
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55793701
95Cell cycle_Homo sapiens_hsa041100.55009264
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54830545
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52534983
98Carbon metabolism_Homo sapiens_hsa012000.45199628
99Glycerolipid metabolism_Homo sapiens_hsa005610.44681163
100Other glycan degradation_Homo sapiens_hsa005110.42315947
101Cardiac muscle contraction_Homo sapiens_hsa042600.41313154
102Serotonergic synapse_Homo sapiens_hsa047260.39903377
103Pentose phosphate pathway_Homo sapiens_hsa000300.38620694
104TGF-beta signaling pathway_Homo sapiens_hsa043500.36287266
105Mineral absorption_Homo sapiens_hsa049780.35406080
106Oocyte meiosis_Homo sapiens_hsa041140.34918837
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34555722
108Non-homologous end-joining_Homo sapiens_hsa034500.34529527
109Collecting duct acid secretion_Homo sapiens_hsa049660.33128602
110Biosynthesis of amino acids_Homo sapiens_hsa012300.31852656
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30630039
112Rheumatoid arthritis_Homo sapiens_hsa053230.30550142
113Phagosome_Homo sapiens_hsa041450.29274364
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27604882
115Bile secretion_Homo sapiens_hsa049760.27427759
116Pancreatic secretion_Homo sapiens_hsa049720.26538547
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.24887823
118Pyrimidine metabolism_Homo sapiens_hsa002400.24615834
119Basal transcription factors_Homo sapiens_hsa030220.24026395
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22941038
121Ovarian steroidogenesis_Homo sapiens_hsa049130.20867559
122Protein digestion and absorption_Homo sapiens_hsa049740.19242202
123Purine metabolism_Homo sapiens_hsa002300.18997828
124Prion diseases_Homo sapiens_hsa050200.18635864
125Renin-angiotensin system_Homo sapiens_hsa046140.18003700
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.17533403
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.14179754
128Galactose metabolism_Homo sapiens_hsa000520.13459464

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