BET1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)5.58648513
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.41152594
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.17562173
4ATP synthesis coupled proton transport (GO:0015986)5.17562173
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.12820260
6respiratory electron transport chain (GO:0022904)4.35401721
7electron transport chain (GO:0022900)4.27168988
8GDP-mannose metabolic process (GO:0019673)4.17651505
9COPI coating of Golgi vesicle (GO:0048205)4.17496882
10Golgi transport vesicle coating (GO:0048200)4.17496882
11protein complex biogenesis (GO:0070271)4.13917428
12GTP biosynthetic process (GO:0006183)4.10285774
13negative regulation of erythrocyte differentiation (GO:0045647)4.04133246
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98238906
15cotranslational protein targeting to membrane (GO:0006613)3.97216514
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.91944180
17protein targeting to ER (GO:0045047)3.90024405
18establishment of protein localization to endoplasmic reticulum (GO:0072599)3.80647918
19protein localization to endoplasmic reticulum (GO:0070972)3.77839149
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.75477944
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.75477944
22NADH dehydrogenase complex assembly (GO:0010257)3.75477944
23antigen processing and presentation of endogenous antigen (GO:0019883)3.72153104
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.71795154
25positive regulation by symbiont of host defense response (GO:0052509)3.70756201
26modulation by symbiont of host defense response (GO:0052031)3.70756201
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.70756201
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.70756201
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.70756201
30modulation by symbiont of host immune response (GO:0052553)3.70756201
31positive regulation of gamma-delta T cell activation (GO:0046645)3.70277255
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.63155868
33negative regulation of cell killing (GO:0031342)3.63155868
34mitochondrial respiratory chain complex assembly (GO:0033108)3.60645694
35ribosomal small subunit assembly (GO:0000028)3.60586295
36fatty acid elongation (GO:0030497)3.59882782
37protein maturation by protein folding (GO:0022417)3.54349451
38ER overload response (GO:0006983)3.48401507
39mannosylation (GO:0097502)3.45315218
40guanosine-containing compound biosynthetic process (GO:1901070)3.42102176
41nucleotide transmembrane transport (GO:1901679)3.39624607
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.37380594
43chaperone-mediated protein transport (GO:0072321)3.35799169
44protein neddylation (GO:0045116)3.33345524
45respiratory chain complex IV assembly (GO:0008535)3.32307461
46peptidyl-histidine modification (GO:0018202)3.31753755
47mannose metabolic process (GO:0006013)3.28275802
48response to peptidoglycan (GO:0032494)3.22248763
49ribosomal small subunit biogenesis (GO:0042274)3.20947896
50UTP biosynthetic process (GO:0006228)3.20501512
51positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.17928478
52response to redox state (GO:0051775)3.16769301
53proteasome assembly (GO:0043248)3.15812125
54cytochrome complex assembly (GO:0017004)3.12964663
55detection of bacterium (GO:0016045)3.12746623
56detection of other organism (GO:0098543)3.11288921
57pinocytosis (GO:0006907)3.09888357
58GPI anchor biosynthetic process (GO:0006506)3.09178917
59transcription elongation from RNA polymerase III promoter (GO:0006385)3.02008635
60termination of RNA polymerase III transcription (GO:0006386)3.02008635
61L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.01918320
62viral transcription (GO:0019083)3.00001485
63stress fiber assembly (GO:0043149)2.99943653
64regulation of early endosome to late endosome transport (GO:2000641)2.98890748
65maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.98233228
66response to laminar fluid shear stress (GO:0034616)2.96995110
67CTP metabolic process (GO:0046036)2.95894301
68CTP biosynthetic process (GO:0006241)2.95894301
69protein localization to endosome (GO:0036010)2.94565826
70regulation of neuron projection regeneration (GO:0070570)2.91515577
71regulation of axon regeneration (GO:0048679)2.91515577
72barbed-end actin filament capping (GO:0051016)2.91313336
73hydrogen ion transmembrane transport (GO:1902600)2.88950983
74positive regulation of Cdc42 GTPase activity (GO:0043089)2.88812838
75protein retention in ER lumen (GO:0006621)2.88025255
76regulation of extracellular matrix disassembly (GO:0010715)2.85719151
77detection of external biotic stimulus (GO:0098581)2.82705267
78translational termination (GO:0006415)2.82240812
79UTP metabolic process (GO:0046051)2.78788700
80energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.76942458
81ATP hydrolysis coupled proton transport (GO:0015991)2.76942458
82regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.75716545
83dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.75301823
84regulation of gamma-delta T cell activation (GO:0046643)2.74310697
85autophagic vacuole fusion (GO:0000046)2.74004856
86GPI anchor metabolic process (GO:0006505)2.73518741
87regulation of oxidative phosphorylation (GO:0002082)2.73058589
88purine nucleoside triphosphate biosynthetic process (GO:0009145)2.73039118
89nucleotide-sugar biosynthetic process (GO:0009226)2.72745760
90NIK/NF-kappaB signaling (GO:0038061)2.72324459
91macrophage activation involved in immune response (GO:0002281)2.71815979
92purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.70237783
93proton transport (GO:0015992)2.70201370
94detection of molecule of bacterial origin (GO:0032490)2.69806021
95response to muramyl dipeptide (GO:0032495)2.68244734
96regulation of type I interferon-mediated signaling pathway (GO:0060338)2.67274717
97water-soluble vitamin biosynthetic process (GO:0042364)2.65860591
98hydrogen transport (GO:0006818)2.63588187
99aldehyde catabolic process (GO:0046185)2.63049104
100protein targeting to membrane (GO:0006612)2.62147795
101phagosome maturation (GO:0090382)2.61202293
102retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60151310
103regulation of mitochondrial translation (GO:0070129)2.59702389
104regulation of interferon-beta biosynthetic process (GO:0045357)2.58341749
105amino acid salvage (GO:0043102)2.58273575
106L-methionine salvage (GO:0071267)2.58273575
107L-methionine biosynthetic process (GO:0071265)2.58273575
108modulation by symbiont of host cellular process (GO:0044068)2.57767097
109peptide hormone processing (GO:0016486)2.57692264
110germinal center formation (GO:0002467)2.57356755
111regulation of leukocyte degranulation (GO:0043300)2.55892877
112regulation of T-helper 2 cell differentiation (GO:0045628)2.55833515
113positive regulation of extracellular matrix organization (GO:1903055)2.55385613
114antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.54965522
115central nervous system myelination (GO:0022010)2.54149329
116axon ensheathment in central nervous system (GO:0032291)2.54149329
117regulation of mast cell degranulation (GO:0043304)2.53988758
118negative regulation of toll-like receptor signaling pathway (GO:0034122)2.53371672
119regulation of metalloenzyme activity (GO:0048552)2.53057394
120intracellular protein transmembrane import (GO:0044743)2.52692566
121nucleoside diphosphate phosphorylation (GO:0006165)2.52649481
122regulation of gamma-delta T cell differentiation (GO:0045586)2.52398630
123response to type I interferon (GO:0034340)2.51849289
124regulation of necroptotic process (GO:0060544)2.51765823
125response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.51714345
126response to host (GO:0075136)2.51714345
127response to host defenses (GO:0052200)2.51714345
128type I interferon signaling pathway (GO:0060337)2.51369548
129cellular response to type I interferon (GO:0071357)2.51369548
1303-UTR-mediated mRNA stabilization (GO:0070935)2.51240861
131skin morphogenesis (GO:0043589)2.50058554
132translation (GO:0006412)2.48555237
133lipopolysaccharide-mediated signaling pathway (GO:0031663)2.48075602
134L-phenylalanine catabolic process (GO:0006559)2.46219773
135erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.46219773
136antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.46005410
137positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.45349790
138negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.45294920
139regulation of myeloid leukocyte mediated immunity (GO:0002886)2.45282219
140intracellular pH reduction (GO:0051452)2.44870261
141positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.44661490
142signal complex assembly (GO:0007172)2.44629588
143antigen processing and presentation via MHC class Ib (GO:0002475)2.44207544
144embryonic process involved in female pregnancy (GO:0060136)2.43476036
145long-chain fatty acid biosynthetic process (GO:0042759)2.42120270
146negative regulation of acute inflammatory response (GO:0002674)2.41916638
147cholesterol biosynthetic process (GO:0006695)2.41749662
148pH reduction (GO:0045851)2.40875710
149response to host immune response (GO:0052572)2.40215725
150response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.40215725
151regulation of vitamin D biosynthetic process (GO:0060556)2.40102504
152protein targeting to mitochondrion (GO:0006626)2.40024649
153activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.40018659
154detection of biotic stimulus (GO:0009595)2.39722727
155dopamine transport (GO:0015872)2.38920347
156modulation by virus of host process (GO:0019054)2.38716197
157negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.38492726
158preassembly of GPI anchor in ER membrane (GO:0016254)2.38193153
159COPII vesicle coating (GO:0048208)2.37729895
160pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.37678607
161immunoglobulin mediated immune response (GO:0016064)2.37624008
162neutrophil activation involved in immune response (GO:0002283)2.37305961
163negative regulation of necroptotic process (GO:0060546)2.35281083
164regulation of type B pancreatic cell apoptotic process (GO:2000674)2.35026760
165fibril organization (GO:0097435)2.34893064
166basement membrane organization (GO:0071711)2.34657973
167ribonucleoside triphosphate biosynthetic process (GO:0009201)2.32460432
168positive regulation of blood vessel endothelial cell migration (GO:0043536)2.31693636
169deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.30794538
170ATP biosynthetic process (GO:0006754)2.30224071
171nucleotide transport (GO:0006862)2.30099763
172nucleoside diphosphate catabolic process (GO:0009134)2.29987775
173positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.29970685
174negative regulation of JUN kinase activity (GO:0043508)2.29963118
175negative regulation of viral release from host cell (GO:1902187)2.29938146
176leukocyte aggregation (GO:0070486)2.29708658
177negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.28961115
178positive regulation of receptor recycling (GO:0001921)2.28860159
179endocrine pancreas development (GO:0031018)2.28570519
180proline biosynthetic process (GO:0006561)2.28084689
181positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.27673856
182negative regulation of interleukin-12 production (GO:0032695)2.27443795
183positive regulation of nuclease activity (GO:0032075)2.27152503
184regulation of B cell receptor signaling pathway (GO:0050855)2.26416012
185regulation of necrotic cell death (GO:0010939)2.25241685
186negative regulation of stress fiber assembly (GO:0051497)2.23902631
187pentose-phosphate shunt (GO:0006098)2.22164837
188regulation of dendritic cell antigen processing and presentation (GO:0002604)2.21881203
189myeloid dendritic cell differentiation (GO:0043011)2.21359745
190positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.20469634
191cellular extravasation (GO:0045123)2.20128249
192regulation of superoxide anion generation (GO:0032928)2.19015036
193negative regulation of protein localization to plasma membrane (GO:1903077)2.18745463
194negative regulation of innate immune response (GO:0045824)2.18601258
195peptidyl-proline hydroxylation (GO:0019511)2.18532773
196vesicle coating (GO:0006901)2.18283193
197hypotonic response (GO:0006971)2.17869302
198positive regulation of cellular amide metabolic process (GO:0034250)2.17452711
199regulation of T cell tolerance induction (GO:0002664)2.16653762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.89969771
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.17975993
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.00180429
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.67862759
5PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.40539005
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.21910102
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.86585254
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81224040
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.77992571
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72049615
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.70072478
12VDR_21846776_ChIP-Seq_THP-1_Human2.67825733
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66134279
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.57065694
15MYC_22102868_ChIP-Seq_BL_Human2.54186598
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.46953167
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46470578
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.45382332
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41908902
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.36960041
21LXR_22292898_ChIP-Seq_THP-1_Human2.32893053
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.23274488
23* ETS1_20019798_ChIP-Seq_JURKAT_Human2.22203673
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.14364692
25KDM2B_26808549_Chip-Seq_SUP-B15_Human2.10768190
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.09434715
27* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.00677329
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99592309
29VDR_24763502_ChIP-Seq_THP-1_Human1.95784786
30TCF7_22412390_ChIP-Seq_EML_Mouse1.95766108
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93966482
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.93589258
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90768063
34KDM2B_26808549_Chip-Seq_DND41_Human1.87582227
35RACK7_27058665_Chip-Seq_MCF-7_Human1.87239672
36MAF_26560356_Chip-Seq_TH1_Human1.85633026
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81767809
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81573847
39GBX2_23144817_ChIP-Seq_PC3_Human1.79732657
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.75496031
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.74608763
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74328765
43GATA1_22025678_ChIP-Seq_K562_Human1.74161361
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72903176
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72203442
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65832857
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.65119123
48UTX_26944678_Chip-Seq_JUKART_Human1.63965931
49* RUNX1_22412390_ChIP-Seq_EML_Mouse1.63843182
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61890240
51CLOCK_20551151_ChIP-Seq_293T_Human1.61128327
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61094098
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61003541
54VDR_22108803_ChIP-Seq_LS180_Human1.60864354
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.56400169
56SPI1_23127762_ChIP-Seq_K562_Human1.54959227
57ELK1_19687146_ChIP-ChIP_HELA_Human1.54515793
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54221093
59MAF_26560356_Chip-Seq_TH2_Human1.52596766
60* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52139300
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51967113
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.51511315
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50623897
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50102051
65DCP1A_22483619_ChIP-Seq_HELA_Human1.48642049
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48274082
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.47177764
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44616147
69NCOR1_26117541_ChIP-Seq_K562_Human1.43807863
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43511721
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42852427
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42501749
73IRF1_19129219_ChIP-ChIP_H3396_Human1.42321623
74* RXR_22158963_ChIP-Seq_LIVER_Mouse1.41248640
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40711004
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38388222
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37923257
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37846573
79TAF15_26573619_Chip-Seq_HEK293_Human1.37794658
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35737398
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35369351
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34827280
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34577668
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34110418
85* SPI1_23547873_ChIP-Seq_NB4_Human1.33769436
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33618977
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.33385471
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33373612
89* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.32795687
90IRF8_27001747_Chip-Seq_BMDM_Mouse1.32282978
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27893102
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.27726425
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.27403903
94KDM2B_26808549_Chip-Seq_K562_Human1.27007538
95VDR_23849224_ChIP-Seq_CD4+_Human1.26374897
96ZNF263_19887448_ChIP-Seq_K562_Human1.25880593
97SCL_19346495_ChIP-Seq_HPC-7_Human1.24285130
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.23783340
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23438911
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22546799
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22381375
102GATA1_19941826_ChIP-Seq_K562_Human1.21546993
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20386561
104BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18370592
105THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17900144
106MYB_26560356_Chip-Seq_TH1_Human1.15698813
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15592965
108* ATF3_27146783_Chip-Seq_COLON_Human1.14993197
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14357822
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.14248476
111CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13452135
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13089117
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13003985
114TET1_21451524_ChIP-Seq_MESCs_Mouse1.12812123
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11969160
116ELF1_20517297_ChIP-Seq_JURKAT_Human1.11626900
117PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11607389
118SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11498060
119ER_23166858_ChIP-Seq_MCF-7_Human1.11112556
120GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10950349
121* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10604542
122TRIM28_21343339_ChIP-Seq_HEK293_Human1.10537906
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10292206
124FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09893744
125P68_20966046_ChIP-Seq_HELA_Human1.09357445
126STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08764935
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08090421
128ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07496399
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06942352
130BCOR_27268052_Chip-Seq_Bcells_Human1.05177628
131MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05124467
132EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04142776
133PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03704060
134GATA2_21666600_ChIP-Seq_HMVEC_Human1.02799528
135ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02266823
136HTT_18923047_ChIP-ChIP_STHdh_Human1.02231365
137PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02193747
138SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02135347
139MYB_26560356_Chip-Seq_TH2_Human1.01917384
140P300_19829295_ChIP-Seq_ESCs_Human1.00522379
141STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99964779
142TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99963992
143SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99742293
144CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99582902
145IRF8_21731497_ChIP-ChIP_J774_Mouse0.99492381
146SMC4_20622854_ChIP-Seq_HELA_Human0.99482227
147STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99096991
148NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99042395
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.97309838
150ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96530975
151CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95714415
152FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95230679
153NOTCH1_21737748_ChIP-Seq_TLL_Human0.94976970
154SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94396773
155FOXP3_21729870_ChIP-Seq_TREG_Human0.94168585
156* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93406266
157E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91469875
158SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91380633
159FLI1_27457419_Chip-Seq_LIVER_Mouse0.89783158
160FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89489809
161SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88414389
162OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87919837
163RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86097505
164CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86042362
165SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85989764
166NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85574912
167NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85574912
168AR_21572438_ChIP-Seq_LNCaP_Human0.85333481
169AR_20517297_ChIP-Seq_VCAP_Human0.83770070
170SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83082221
171ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.82397467
172STAT3_18555785_Chip-Seq_ESCs_Mouse0.82260395
173SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.82053624
174RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81166345
175CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.81084536
176EED_16625203_ChIP-ChIP_MESCs_Mouse0.80999002
177BP1_19119308_ChIP-ChIP_Hs578T_Human0.80454726
178* GABP_19822575_ChIP-Seq_HepG2_Human0.79393874
179YY1_21170310_ChIP-Seq_MESCs_Mouse0.79348061
180TP53_22573176_ChIP-Seq_HFKS_Human0.78952962
181NANOG_18555785_Chip-Seq_ESCs_Mouse0.78886339
182P53_22387025_ChIP-Seq_ESCs_Mouse0.78696105
183LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78439434
184GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.76629206
185TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75084868
186ERG_20517297_ChIP-Seq_VCAP_Human0.74624518
187SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74467098
188SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.74117048
189TAL1_26923725_Chip-Seq_HPCs_Mouse0.73872958
190* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.73075591
191EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.73006471
192TP53_18474530_ChIP-ChIP_U2OS_Human0.72866737

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.77961039
2MP0008438_abnormal_cutaneous_collagen3.56288126
3MP0005379_endocrine/exocrine_gland_phen3.11885838
4MP0003705_abnormal_hypodermis_morpholog3.04439677
5MP0003136_yellow_coat_color3.03435541
6MP0005451_abnormal_body_composition2.90894552
7MP0003195_calcinosis2.90508556
8MP0003303_peritoneal_inflammation2.81997689
9MP0010386_abnormal_urinary_bladder2.81886764
10MP0003880_abnormal_central_pattern2.80479722
11MP0009697_abnormal_copulation2.62888053
12MP0000013_abnormal_adipose_tissue2.61449815
13MP0008260_abnormal_autophagy2.51060002
14MP0009840_abnormal_foam_cell2.47571214
15MP0003300_gastrointestinal_ulcer2.35394087
16MP0001905_abnormal_dopamine_level2.28140893
17MP0003191_abnormal_cellular_cholesterol2.27745792
18MP0003566_abnormal_cell_adhesion2.21787956
19MP0005464_abnormal_platelet_physiology2.18351757
20MP0003172_abnormal_lysosome_physiology2.10679257
21MP0002163_abnormal_gland_morphology2.09971827
22MP0005409_darkened_coat_color2.05422906
23MP0003186_abnormal_redox_activity2.01816927
24MP0000678_abnormal_parathyroid_gland1.99837759
25MP0002693_abnormal_pancreas_physiology1.89020717
26MP0003279_aneurysm1.86661650
27MP0000685_abnormal_immune_system1.84123504
28MP0004947_skin_inflammation1.82890720
29MP0005084_abnormal_gallbladder_morpholo1.80862531
30MP0003806_abnormal_nucleotide_metabolis1.79827858
31MP0003183_abnormal_peptide_metabolism1.79520948
32MP0008875_abnormal_xenobiotic_pharmacok1.78900977
33MP0002876_abnormal_thyroid_physiology1.77330411
34MP0001764_abnormal_homeostasis1.76300419
35MP0000858_altered_metastatic_potential1.75650390
36MP0002638_abnormal_pupillary_reflex1.75471720
37MP0001529_abnormal_vocalization1.73119370
38MP0001986_abnormal_taste_sensitivity1.72564465
39MP0003091_abnormal_cell_migration1.67139309
40MP0002735_abnormal_chemical_nociception1.67102457
41MP0009333_abnormal_splenocyte_physiolog1.65063652
42MP0005220_abnormal_exocrine_pancreas1.64611886
43MP0009780_abnormal_chondrocyte_physiolo1.63735779
44MP0009278_abnormal_bone_marrow1.63583083
45MP0005171_absent_coat_pigmentation1.62275437
46MP0008004_abnormal_stomach_pH1.61265182
47MP0003763_abnormal_thymus_physiology1.61107268
48MP0005275_abnormal_skin_tensile1.59702556
49MP0001958_emphysema1.59355660
50MP0001800_abnormal_humoral_immune1.53459727
51MP0000681_abnormal_thyroid_gland1.53009820
52MP0002837_dystrophic_cardiac_calcinosis1.52966213
53MP0001944_abnormal_pancreas_morphology1.50099857
54MP0002998_abnormal_bone_remodeling1.49771115
55MP0005636_abnormal_mineral_homeostasis1.49172177
56MP0002132_abnormal_respiratory_system1.47148007
57MP0010155_abnormal_intestine_physiology1.46895264
58MP0002148_abnormal_hypersensitivity_rea1.46778580
59MP0002295_abnormal_pulmonary_circulatio1.46492439
60MP0006292_abnormal_olfactory_placode1.45126785
61MP0002452_abnormal_antigen_presenting1.43986632
62MP0000372_irregular_coat_pigmentation1.43063229
63MP0005023_abnormal_wound_healing1.41493830
64MP0001849_ear_inflammation1.41271895
65MP0002420_abnormal_adaptive_immunity1.39712059
66MP0001819_abnormal_immune_cell1.39087076
67MP0002736_abnormal_nociception_after1.38295701
68MP0003724_increased_susceptibility_to1.37284157
69MP0004272_abnormal_basement_membrane1.37094121
70MP0004043_abnormal_pH_regulation1.37001959
71MP0009785_altered_susceptibility_to1.36889369
72MP0004858_abnormal_nervous_system1.33745285
73MP0001664_abnormal_digestion1.33236723
74MP0006036_abnormal_mitochondrial_physio1.31410548
75MP0001968_abnormal_touch/_nociception1.30022021
76MP0001188_hyperpigmentation1.29552805
77MP0000920_abnormal_myelination1.28953709
78MP0005408_hypopigmentation1.28704019
79MP0006082_CNS_inflammation1.28256269
80MP0000015_abnormal_ear_pigmentation1.27366351
81MP0003453_abnormal_keratinocyte_physiol1.27300921
82MP0001545_abnormal_hematopoietic_system1.27124100
83MP0005397_hematopoietic_system_phenotyp1.27124100
84MP0002405_respiratory_system_inflammati1.26757098
85MP0002138_abnormal_hepatobiliary_system1.26724359
86MP0001835_abnormal_antigen_presentation1.25999369
87MP0005257_abnormal_intraocular_pressure1.25894103
88MP0005076_abnormal_cell_differentiation1.24371424
89MP0006276_abnormal_autonomic_nervous1.23774042
90MP0002398_abnormal_bone_marrow1.23220127
91MP0005360_urolithiasis1.21444696
92MP0003828_pulmonary_edema1.20403242
93MP0005671_abnormal_response_to1.20208201
94MP0004510_myositis1.17574439
95MP0001845_abnormal_inflammatory_respons1.17523238
96MP0005365_abnormal_bile_salt1.15960998
97MP0000613_abnormal_salivary_gland1.14583142
98MP0002139_abnormal_hepatobiliary_system1.13596042
99MP0002396_abnormal_hematopoietic_system1.13517793
100MP0000716_abnormal_immune_system1.12884171
101MP0002933_joint_inflammation1.12736662
102MP0001666_abnormal_nutrient_absorption1.12334745
103MP0004381_abnormal_hair_follicle1.11520061
104MP0001765_abnormal_ion_homeostasis1.11381231
105MP0003011_delayed_dark_adaptation1.10720673
106MP0002272_abnormal_nervous_system1.09017698
107MP0001542_abnormal_bone_strength1.08797477
108MP0002419_abnormal_innate_immunity1.07848424
109MP0004270_analgesia1.07178029
110MP0001853_heart_inflammation1.07043902
111MP0003075_altered_response_to1.06172022
112MP0001851_eye_inflammation1.06038150
113MP0005503_abnormal_tendon_morphology1.05784217
114MP0002734_abnormal_mechanical_nocicepti1.05432068
115MP0010234_abnormal_vibrissa_follicle1.04780482
116MP0002722_abnormal_immune_system1.04518651
117MP0005390_skeleton_phenotype1.03607852
118MP0002429_abnormal_blood_cell1.03019270
119MP0005025_abnormal_response_to1.02903729
120MP0004782_abnormal_surfactant_physiolog1.02796277
121MP0005058_abnormal_lysosome_morphology1.01624744
122MP0003879_abnormal_hair_cell1.01115281
123MP0000343_altered_response_to0.99735475
124MP0002064_seizures0.98982371
125MP0002060_abnormal_skin_morphology0.98186383
126MP0004808_abnormal_hematopoietic_stem0.97932102
127MP0005000_abnormal_immune_tolerance0.97616953
128MP0002938_white_spotting0.97549219
129MP0004264_abnormal_extraembryonic_tissu0.97318003
130MP0000767_abnormal_smooth_muscle0.97262378
131MP0004883_abnormal_blood_vessel0.96058031
132MP0002909_abnormal_adrenal_gland0.95100695
133MP0003448_altered_tumor_morphology0.94840656
134MP0003656_abnormal_erythrocyte_physiolo0.94394772
135MP0000689_abnormal_spleen_morphology0.93655016
136MP0001501_abnormal_sleep_pattern0.93417750
137MP0003795_abnormal_bone_structure0.92443579
138MP0009745_abnormal_behavioral_response0.92129913
139MP0004142_abnormal_muscle_tone0.91899836
140MP0003868_abnormal_feces_composition0.91749548
141MP0001970_abnormal_pain_threshold0.91283118
142MP0000703_abnormal_thymus_morphology0.89960663
143MP0002877_abnormal_melanocyte_morpholog0.89774955
144MP0000538_abnormal_urinary_bladder0.89647854
145MP0005164_abnormal_response_to0.88400794
146MP0005387_immune_system_phenotype0.87428409
147MP0001790_abnormal_immune_system0.87428409
148MP0005621_abnormal_cell_physiology0.85973622
149MP0010352_gastrointestinal_tract_polyps0.85921178
150MP0000604_amyloidosis0.85795460
151MP0000490_abnormal_crypts_of0.85713755
152MP0002796_impaired_skin_barrier0.85534948
153MP0008469_abnormal_protein_level0.85271461
154MP0005166_decreased_susceptibility_to0.83580771
155MP0001915_intracranial_hemorrhage0.82361597
156MP0002078_abnormal_glucose_homeostasis0.81522807
157MP0005535_abnormal_body_temperature0.81422756
158MP0005645_abnormal_hypothalamus_physiol0.80164973
159MP0005381_digestive/alimentary_phenotyp0.79365400
160MP0005332_abnormal_amino_acid0.78714438
161MP0002572_abnormal_emotion/affect_behav0.78228841
162MP0000249_abnormal_blood_vessel0.77817066
163MP0003866_abnormal_defecation0.77747332
164MP0005646_abnormal_pituitary_gland0.77409790
165MP0001348_abnormal_lacrimal_gland0.77174922
166MP0001533_abnormal_skeleton_physiology0.76722763
167MP0009643_abnormal_urine_homeostasis0.76409695
168MP0000465_gastrointestinal_hemorrhage0.76183338
169MP0002723_abnormal_immune_serum0.75917901
170MP0000230_abnormal_systemic_arterial0.75627271
171MP0005310_abnormal_salivary_gland0.74243456
172MP0003436_decreased_susceptibility_to0.73810508
173MP0001502_abnormal_circadian_rhythm0.72564752
174MP0001663_abnormal_digestive_system0.71577780
175MP0003959_abnormal_lean_body0.70644378
176MP0002733_abnormal_thermal_nociception0.70588522
177MP0005083_abnormal_biliary_tract0.68601985

Predicted human phenotypes

RankGene SetZ-score
1Renal Fanconi syndrome (HP:0001994)5.59004993
2Acute necrotizing encephalopathy (HP:0006965)4.81015243
3Mitochondrial inheritance (HP:0001427)4.32954783
4Abnormal mitochondria in muscle tissue (HP:0008316)4.13997234
5Acute encephalopathy (HP:0006846)3.98560565
6Increased hepatocellular lipid droplets (HP:0006565)3.94319535
73-Methylglutaconic aciduria (HP:0003535)3.89726007
8Progressive macrocephaly (HP:0004481)3.87754384
9Protrusio acetabuli (HP:0003179)3.83038908
10Premature rupture of membranes (HP:0001788)3.82006387
11Abnormality of renal resorption (HP:0011038)3.64340186
12Lipid accumulation in hepatocytes (HP:0006561)3.59397925
13Eczematoid dermatitis (HP:0000976)3.57060751
14Increased CSF lactate (HP:0002490)3.47791230
15Hepatocellular necrosis (HP:0001404)3.29000994
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.23852897
17Abnormality of macrophages (HP:0004311)3.17817339
18Hepatic necrosis (HP:0002605)3.17777399
19Abnormality of calcium-phosphate metabolism (HP:0100530)3.17574951
20Symptomatic seizures (HP:0011145)3.17483248
21Hyperphosphaturia (HP:0003109)3.11745533
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.99034987
23Peritonitis (HP:0002586)2.96723472
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.92090632
25Parakeratosis (HP:0001036)2.89625693
26Generalized aminoaciduria (HP:0002909)2.82307320
27Vertebral compression fractures (HP:0002953)2.81248892
28Retinal dysplasia (HP:0007973)2.80588608
29Vacuolated lymphocytes (HP:0001922)2.79441966
30Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.78445688
31Cerebral edema (HP:0002181)2.71865228
32Exertional dyspnea (HP:0002875)2.68898492
33Abnormality of aromatic amino acid family metabolism (HP:0004338)2.67827785
34Increased intramyocellular lipid droplets (HP:0012240)2.58355235
35Dilatation of the ascending aorta (HP:0005111)2.58294662
36Hyperparathyroidism (HP:0000843)2.57420665
37Aortic aneurysm (HP:0004942)2.56550117
38Systemic lupus erythematosus (HP:0002725)2.51563223
39Abnormal urine phosphate concentration (HP:0012599)2.49822346
40Cellulitis (HP:0100658)2.49419999
41Prolonged partial thromboplastin time (HP:0003645)2.49106818
42Type I transferrin isoform profile (HP:0003642)2.46155936
43Cervical subluxation (HP:0003308)2.43220357
44Hemorrhage of the eye (HP:0011885)2.43136979
45Optic disc pallor (HP:0000543)2.41737301
46Dysostosis multiplex (HP:0000943)2.40786622
47Deep venous thrombosis (HP:0002625)2.40614467
48Polycythemia (HP:0001901)2.40519034
49Prolonged bleeding time (HP:0003010)2.40032997
50Gingival bleeding (HP:0000225)2.39777373
51Gastrointestinal infarctions (HP:0005244)2.38499460
52Myositis (HP:0100614)2.38221337
53Aortic dissection (HP:0002647)2.35444674
54Exercise intolerance (HP:0003546)2.34994340
55Petechiae (HP:0000967)2.34985562
56Lactic acidosis (HP:0003128)2.34723400
57Epistaxis (HP:0000421)2.34610074
58Recurrent abscess formation (HP:0002722)2.34316352
59Increased IgE level (HP:0003212)2.31651816
60Cholecystitis (HP:0001082)2.31121608
61Abnormal gallbladder physiology (HP:0012438)2.31121608
62Hypothermia (HP:0002045)2.29965151
63Blue sclerae (HP:0000592)2.29914454
64Protuberant abdomen (HP:0001538)2.28263578
65Increased variability in muscle fiber diameter (HP:0003557)2.28175143
66Cerebral aneurysm (HP:0004944)2.27856426
67Orchitis (HP:0100796)2.25657930
68Recurrent bacterial skin infections (HP:0005406)2.25047370
69Renal tubular dysfunction (HP:0000124)2.24051892
70Glycosuria (HP:0003076)2.23757625
71Abnormality of urine glucose concentration (HP:0011016)2.23757625
72Abnormal protein glycosylation (HP:0012346)2.22176172
73Abnormal glycosylation (HP:0012345)2.22176172
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22176172
75Abnormal protein N-linked glycosylation (HP:0012347)2.22176172
76Respiratory failure (HP:0002878)2.21774224
77Osteomalacia (HP:0002749)2.19966883
78Leukodystrophy (HP:0002415)2.18994935
79Increased serum lactate (HP:0002151)2.18776190
80Colitis (HP:0002583)2.18345509
81Increased muscle lipid content (HP:0009058)2.17787126
82Spontaneous hematomas (HP:0007420)2.17597254
83Methylmalonic acidemia (HP:0002912)2.17268494
84Abnormality of dentin (HP:0010299)2.17172153
85Aneurysm (HP:0002617)2.17023396
86Type II lissencephaly (HP:0007260)2.16268128
87Increased connective tissue (HP:0009025)2.16003932
88Spondylolisthesis (HP:0003302)2.14375185
89Menorrhagia (HP:0000132)2.14049201
90Emphysema (HP:0002097)2.13769631
91Congenital ichthyosiform erythroderma (HP:0007431)2.11864225
92Respiratory difficulties (HP:0002880)2.11585185
93Vascular tortuosity (HP:0004948)2.11259141
94Increased serum pyruvate (HP:0003542)2.11153291
95Abnormality of glycolysis (HP:0004366)2.11153291
96Chronic obstructive pulmonary disease (HP:0006510)2.10950782
97Obstructive lung disease (HP:0006536)2.10950782
98Disproportionate tall stature (HP:0001519)2.10061079
99Segmental peripheral demyelination/remyelination (HP:0003481)2.09574452
100Gastrointestinal inflammation (HP:0004386)2.09461233
101Abnormality of skeletal muscle fiber size (HP:0012084)2.09202075
102Upper limb amyotrophy (HP:0009129)2.09189457
103Distal upper limb amyotrophy (HP:0007149)2.09189457
104Dysautonomia (HP:0002459)2.08869485
105Flat capital femoral epiphysis (HP:0003370)2.08598043
106Enlarged epiphyses (HP:0010580)2.07078129
107Proximal tubulopathy (HP:0000114)2.07046650
108Hypertensive crisis (HP:0100735)2.06613269
109Fragile skin (HP:0001030)2.06600449
110Mucopolysacchariduria (HP:0008155)2.06578213
111Urinary glycosaminoglycan excretion (HP:0003541)2.06578213
112Abnormality of the peritoneum (HP:0002585)2.05628374
113Delusions (HP:0000746)2.05311496
114Methylmalonic aciduria (HP:0012120)2.05150080
115Elevated erythrocyte sedimentation rate (HP:0003565)2.04653669
116Genu recurvatum (HP:0002816)2.04232019
117Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03960906
118Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03960906
119Conjugated hyperbilirubinemia (HP:0002908)2.03340722
120Metaphyseal irregularity (HP:0003025)2.03100283
121Irregular vertebral endplates (HP:0003301)2.02978137
122Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02347701
123Abnormality of polysaccharide metabolism (HP:0011012)2.02347701
124Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02347701
125Achilles tendon contracture (HP:0001771)2.02334260
126Delayed epiphyseal ossification (HP:0002663)2.01738070
127Increased serum ferritin (HP:0003281)2.00587803
128Abnormality of liposaccharide metabolism (HP:0010968)1.99389219
129Abnormality of glycosphingolipid metabolism (HP:0004343)1.99389219
130Abnormality of glycolipid metabolism (HP:0010969)1.99389219
131Abnormality of complement system (HP:0005339)1.98753345
132Abnormality of the Achilles tendon (HP:0005109)1.97948373
133Gingivitis (HP:0000230)1.97469852
134Aplastic anemia (HP:0001915)1.96980866
135Recurrent gram-negative bacterial infections (HP:0005420)1.96761102
136Irregular epiphyses (HP:0010582)1.96499463
137Abnormal platelet volume (HP:0011876)1.96045951
138Inflammation of the large intestine (HP:0002037)1.95062186
139Centrally nucleated skeletal muscle fibers (HP:0003687)1.94881275
140Impaired platelet aggregation (HP:0003540)1.93683045
141Abnormal platelet function (HP:0011869)1.93683045
142Thin bony cortex (HP:0002753)1.93217100
143Arterial tortuosity (HP:0005116)1.92757299
144Myocardial infarction (HP:0001658)1.91875283
145Atrophic scars (HP:0001075)1.91072847
146Abnormality of cells of the erythroid lineage (HP:0012130)1.89550035
147Microvesicular hepatic steatosis (HP:0001414)1.88179320
148Cerebellar dysplasia (HP:0007033)1.87629315
149Loss of speech (HP:0002371)1.87138394
150Abnormality of the thoracic spine (HP:0100711)1.86998961
151Thoracic kyphosis (HP:0002942)1.86869045
152Amyloidosis (HP:0011034)1.86336529
153Hypomagnesemia (HP:0002917)1.85892637
154Abnormality of magnesium homeostasis (HP:0004921)1.85416960
155Mediastinal lymphadenopathy (HP:0100721)1.84692554
156Patchy hypopigmentation of hair (HP:0011365)1.83226152
157Gastrointestinal dysmotility (HP:0002579)1.82578772
158Abnormal number of erythroid precursors (HP:0012131)1.82542091
159Gastrointestinal stroma tumor (HP:0100723)1.82161610
160Wormian bones (HP:0002645)1.80030499
161Abnormality of the vertebral endplates (HP:0005106)1.79463914
162Spinal rigidity (HP:0003306)1.78676079
163Abnormal hemoglobin (HP:0011902)1.78391267
164Medial flaring of the eyebrow (HP:0010747)1.78157325
165Broad face (HP:0000283)1.77937981
166Fatigue (HP:0012378)1.77593292
167Recurrent fungal infections (HP:0002841)1.77347667
168Interstitial pulmonary disease (HP:0006530)1.75916494
169Brushfield spots (HP:0001088)1.75826960
170Glomerulonephritis (HP:0000099)1.75737712
171Recurrent viral infections (HP:0004429)1.75737521
172Long palpebral fissure (HP:0000637)1.75676819
173Hand muscle atrophy (HP:0009130)1.75338205
174Metaphyseal cupping (HP:0003021)1.74614062
175Neuroendocrine neoplasm (HP:0100634)1.74411831
176Hypertriglyceridemia (HP:0002155)1.74217138
177Distal lower limb amyotrophy (HP:0008944)1.73793485
178Obstructive sleep apnea (HP:0002870)1.72698744
179Vasculitis (HP:0002633)1.72306171
180Epiphyseal dysplasia (HP:0002656)1.71870892
181Slow saccadic eye movements (HP:0000514)1.71540084
182Biconcave vertebral bodies (HP:0004586)1.71286551
183Abnormal autonomic nervous system physiology (HP:0012332)1.70034297
184Beaking of vertebral bodies (HP:0004568)1.69597666
185Lethargy (HP:0001254)1.68985001
186Metaphyseal dysplasia (HP:0100255)1.67902507
187Macrocytic anemia (HP:0001972)1.67703042
188Hypophosphatemia (HP:0002148)1.62351135
189Atelectasis (HP:0100750)1.61875707
190Abnormality of vitamin metabolism (HP:0100508)1.61059963
191Reduced antithrombin III activity (HP:0001976)1.60991119
192Hyperinsulinemic hypoglycemia (HP:0000825)1.60539931
193Hypoglycemic coma (HP:0001325)1.60163947
194Neurofibrillary tangles (HP:0002185)1.58910051
195Abnormal epiphyseal ossification (HP:0010656)1.57366451
196Purpura (HP:0000979)1.57184501
197White forelock (HP:0002211)1.56664183
198X-linked dominant inheritance (HP:0001423)1.55191346
199Abnormal ciliary motility (HP:0012262)1.54922829

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.38120036
2PRPF4B3.71059394
3TRIB33.10826580
4STK162.98917611
5BCKDK2.70731013
6INSRR2.41170003
7CASK2.38276616
8MAPK152.34624737
9SIK12.27757649
10NME12.23002762
11MAP3K122.22125438
12SMG12.17396498
13MAP4K12.16193906
14ARAF2.13473135
15PIK3CG2.12412578
16TYK22.09274702
17BMPR22.01464405
18RIPK42.00833053
19FGFR41.98584134
20MAP2K31.95874849
21BMPR1B1.89082549
22EPHA31.88713266
23PBK1.88265505
24TNIK1.86148863
25MST41.73322025
26EPHA41.70950540
27RIPK11.69592630
28TLK11.68406731
29PIM21.68041582
30ICK1.65987425
31TAOK21.65724365
32TAOK31.64692085
33CDK121.55129193
34ZAP701.54107453
35CDK191.53676416
36ADRBK21.44542296
37MAP3K11.40633125
38KSR21.38972893
39IRAK11.38268189
40EEF2K1.37168931
41CDC42BPA1.37115439
42EIF2AK31.36975939
43MAP3K31.34509371
44PRKD21.31051000
45IRAK41.29051448
46PDGFRA1.27081583
47VRK11.26364323
48PKN21.26241149
49TAOK11.23871905
50BLK1.22201273
51IRAK31.21400598
52CSK1.20759225
53PIK3CA1.20278856
54PTK2B1.17217209
55OXSR11.17034747
56MAP2K71.16259024
57MAP3K101.13323729
58MAP3K141.13167253
59MYLK1.12024255
60MAP3K131.10689620
61MAP3K111.10561129
62TESK11.10386487
63FLT31.07943614
64BRAF1.05581267
65MUSK1.04710573
66NTRK11.02906340
67NLK0.99847416
68PAK40.99446290
69PTK60.99250456
70GRK70.98280353
71JAK10.97910270
72GRK50.97436517
73TXK0.96624684
74HIPK20.95693998
75BMX0.95653989
76DDR20.94168056
77SYK0.93970497
78MARK20.93613952
79PDPK10.90600423
80DYRK20.90349692
81MET0.89348343
82STK390.88139336
83LRRK20.86086104
84MAPKAPK50.83427227
85EPHA20.81995272
86TGFBR20.81654330
87HCK0.80686928
88TEC0.80195817
89STK380.80018593
90TNK20.79307454
91EPHB10.79240309
92MAPK110.78956592
93CAMK2B0.77735180
94NEK90.77451820
95PRKCE0.76283475
96FGFR30.75961240
97NTRK30.75241903
98DAPK30.74893025
99TTN0.74597230
100PRKG20.74203869
101AKT30.73757495
102GRK10.73567846
103MAPK130.73020401
104MAP3K60.72837649
105IKBKE0.72731199
106PTK20.72518408
107ERN10.72377657
108JAK30.71039588
109ABL20.70905471
110IRAK20.70492421
111JAK20.70450948
112BTK0.69490224
113MAP3K80.68735040
114PLK20.68188569
115IKBKB0.68101554
116CSF1R0.67040420
117CAMK2D0.66972496
118NEK60.66552578
119FGR0.66470717
120MTOR0.66421062
121MST1R0.66277712
122LYN0.65979997
123RET0.64939982
124MARK30.63689672
125PDK10.63213259
126LMTK20.63105348
127CAMK2A0.62152489
128SIK20.61983810
129MOS0.61613691
130WNK40.61028342
131STK100.60254087
132PKN10.59711986
133FES0.58926915
134MAP3K70.58016866
135MAP3K20.56106767
136MATK0.54617337
137MAPK120.52848606
138CLK10.52180776
139MAPK70.51517683
140MAPKAPK20.51394613
141TESK20.51228704
142ADRBK10.50836101
143SIK30.50645297
144RAF10.49866784
145TRPM70.48500123
146TBK10.48176769
147CAMKK20.47863426
148KIT0.47099137
149UHMK10.46860917
150RPS6KA20.46729879
151CDK80.45960623
152GRK60.45491459
153RPS6KA50.44669931
154CAMK2G0.44358490
155LCK0.44315430
156TIE10.43420310
157PDGFRB0.43162045
158PASK0.41846934
159MAP3K50.41782743
160BCR0.41553773
161RPS6KC10.41461446
162RPS6KL10.41461446
163DAPK10.40588764
164PRKCQ0.40164397
165PRKCD0.39277277
166ACVR1B0.37896058
167YES10.37460878
168ZAK0.36952302
169PRKACA0.36919699
170MAP2K20.35211995

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.91976100
2Oxidative phosphorylation_Homo sapiens_hsa001904.60350313
3Parkinsons disease_Homo sapiens_hsa050123.37697706
4Ribosome_Homo sapiens_hsa030103.31883667
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.96486804
6Alzheimers disease_Homo sapiens_hsa050102.91342219
7Sulfur metabolism_Homo sapiens_hsa009202.64002858
8Proteasome_Homo sapiens_hsa030502.50128028
9Steroid biosynthesis_Homo sapiens_hsa001002.35076797
10Huntingtons disease_Homo sapiens_hsa050162.34156575
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.32290092
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.29099774
13Acute myeloid leukemia_Homo sapiens_hsa052212.14670949
14Vibrio cholerae infection_Homo sapiens_hsa051102.13836284
15Osteoclast differentiation_Homo sapiens_hsa043802.06254080
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.04507722
17Fatty acid elongation_Homo sapiens_hsa000622.03956137
18* SNARE interactions in vesicular transport_Homo sapiens_hsa041301.98860154
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97367602
20Collecting duct acid secretion_Homo sapiens_hsa049661.95988946
21B cell receptor signaling pathway_Homo sapiens_hsa046621.89799784
22Leishmaniasis_Homo sapiens_hsa051401.89478058
23RNA polymerase_Homo sapiens_hsa030201.82158384
24Staphylococcus aureus infection_Homo sapiens_hsa051501.75716510
25Chronic myeloid leukemia_Homo sapiens_hsa052201.69290304
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.64741557
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62218970
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.59003047
29Folate biosynthesis_Homo sapiens_hsa007901.57325369
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56233347
31Rheumatoid arthritis_Homo sapiens_hsa053231.53090947
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44714219
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.43923060
34Non-small cell lung cancer_Homo sapiens_hsa052231.41789896
35Pancreatic cancer_Homo sapiens_hsa052121.41599164
36Tuberculosis_Homo sapiens_hsa051521.38447815
37Toxoplasmosis_Homo sapiens_hsa051451.37332152
38Influenza A_Homo sapiens_hsa051641.36966885
39Hepatitis B_Homo sapiens_hsa051611.34951027
40TNF signaling pathway_Homo sapiens_hsa046681.30843407
41Measles_Homo sapiens_hsa051621.28191733
42Hepatitis C_Homo sapiens_hsa051601.26267672
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25705656
44Other glycan degradation_Homo sapiens_hsa005111.25269261
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24922544
46VEGF signaling pathway_Homo sapiens_hsa043701.22877066
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22220801
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21406666
49Bladder cancer_Homo sapiens_hsa052191.19999857
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19920574
51Sphingolipid metabolism_Homo sapiens_hsa006001.18322017
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.17995355
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16766663
54Amoebiasis_Homo sapiens_hsa051461.16424663
55Notch signaling pathway_Homo sapiens_hsa043301.16202067
56Herpes simplex infection_Homo sapiens_hsa051681.16187119
57Apoptosis_Homo sapiens_hsa042101.16067381
58Fructose and mannose metabolism_Homo sapiens_hsa000511.15440761
59Shigellosis_Homo sapiens_hsa051311.14670414
60Complement and coagulation cascades_Homo sapiens_hsa046101.12608186
61Sulfur relay system_Homo sapiens_hsa041221.11767762
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11110132
63Phagosome_Homo sapiens_hsa041451.10674996
64Pentose phosphate pathway_Homo sapiens_hsa000301.10637391
65Cyanoamino acid metabolism_Homo sapiens_hsa004601.10251292
66Prion diseases_Homo sapiens_hsa050201.09724949
67Renal cell carcinoma_Homo sapiens_hsa052111.07408284
68T cell receptor signaling pathway_Homo sapiens_hsa046601.06207471
69Galactose metabolism_Homo sapiens_hsa000521.05560734
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05557578
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04970328
72Viral myocarditis_Homo sapiens_hsa054161.04811716
73Thyroid cancer_Homo sapiens_hsa052161.01060808
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00889824
75Endometrial cancer_Homo sapiens_hsa052131.00573467
76Central carbon metabolism in cancer_Homo sapiens_hsa052301.00337256
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00270219
78Focal adhesion_Homo sapiens_hsa045101.00080562
79Platelet activation_Homo sapiens_hsa046110.98094058
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97468520
81Chemokine signaling pathway_Homo sapiens_hsa040620.94620452
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.93894770
83Regulation of autophagy_Homo sapiens_hsa041400.93015974
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.91580018
85Autoimmune thyroid disease_Homo sapiens_hsa053200.89086566
86Serotonergic synapse_Homo sapiens_hsa047260.88943645
87Chemical carcinogenesis_Homo sapiens_hsa052040.87965250
88Endocytosis_Homo sapiens_hsa041440.87298657
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86597513
90Small cell lung cancer_Homo sapiens_hsa052220.86482355
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86351009
92Graft-versus-host disease_Homo sapiens_hsa053320.85711293
93Pyrimidine metabolism_Homo sapiens_hsa002400.85697811
94Metabolic pathways_Homo sapiens_hsa011000.85482556
95Insulin secretion_Homo sapiens_hsa049110.83679877
96Histidine metabolism_Homo sapiens_hsa003400.81250419
97Legionellosis_Homo sapiens_hsa051340.80932975
98Peroxisome_Homo sapiens_hsa041460.80706831
99Prostate cancer_Homo sapiens_hsa052150.80663637
100Insulin resistance_Homo sapiens_hsa049310.80302880
101Ether lipid metabolism_Homo sapiens_hsa005650.80033883
102mTOR signaling pathway_Homo sapiens_hsa041500.78873821
103Arachidonic acid metabolism_Homo sapiens_hsa005900.76589863
104Phenylalanine metabolism_Homo sapiens_hsa003600.76177992
105Prolactin signaling pathway_Homo sapiens_hsa049170.75550807
106Proteoglycans in cancer_Homo sapiens_hsa052050.75410055
107Antigen processing and presentation_Homo sapiens_hsa046120.73693699
108HIF-1 signaling pathway_Homo sapiens_hsa040660.73314164
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.72364447
110HTLV-I infection_Homo sapiens_hsa051660.72121002
111Salmonella infection_Homo sapiens_hsa051320.72094737
112Cardiac muscle contraction_Homo sapiens_hsa042600.71518561
113Lysosome_Homo sapiens_hsa041420.71137097
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71007874
115Insulin signaling pathway_Homo sapiens_hsa049100.70172371
116Type I diabetes mellitus_Homo sapiens_hsa049400.69808740
117Linoleic acid metabolism_Homo sapiens_hsa005910.69079978
118Viral carcinogenesis_Homo sapiens_hsa052030.69013042
119African trypanosomiasis_Homo sapiens_hsa051430.68960181
120N-Glycan biosynthesis_Homo sapiens_hsa005100.68661820
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68257085
122Taste transduction_Homo sapiens_hsa047420.68214198
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66635251
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65965840
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.65878463
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65785870
127Choline metabolism in cancer_Homo sapiens_hsa052310.65254748
128Inositol phosphate metabolism_Homo sapiens_hsa005620.64827790
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.63836840
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63546794
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62927319
132Tyrosine metabolism_Homo sapiens_hsa003500.62710092
133Glutathione metabolism_Homo sapiens_hsa004800.62529465
134Pancreatic secretion_Homo sapiens_hsa049720.62447862
135ErbB signaling pathway_Homo sapiens_hsa040120.61560462
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60900546
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60268765
138Purine metabolism_Homo sapiens_hsa002300.60139187
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59715452
140ECM-receptor interaction_Homo sapiens_hsa045120.59649488
141Synaptic vesicle cycle_Homo sapiens_hsa047210.58193175
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.56762307
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56197817
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55499430
145Butanoate metabolism_Homo sapiens_hsa006500.55305825
146GABAergic synapse_Homo sapiens_hsa047270.53772135
147Glioma_Homo sapiens_hsa052140.53491624
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51504410
149GnRH signaling pathway_Homo sapiens_hsa049120.50881124
150Epstein-Barr virus infection_Homo sapiens_hsa051690.50581840
151Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49876189
152Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48040072
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47838645
154Colorectal cancer_Homo sapiens_hsa052100.47706960
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46117321
156Nicotine addiction_Homo sapiens_hsa050330.45414158
157Arginine and proline metabolism_Homo sapiens_hsa003300.42522682
158alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42141749
159Morphine addiction_Homo sapiens_hsa050320.41369592
160Allograft rejection_Homo sapiens_hsa053300.40450220
161Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39288266
162Drug metabolism - other enzymes_Homo sapiens_hsa009830.38712426
163Caffeine metabolism_Homo sapiens_hsa002320.38488300
164Retinol metabolism_Homo sapiens_hsa008300.37442643
165Glutamatergic synapse_Homo sapiens_hsa047240.37090008
166Circadian entrainment_Homo sapiens_hsa047130.36390421
167Hematopoietic cell lineage_Homo sapiens_hsa046400.35135658
168Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34116735
169Pyruvate metabolism_Homo sapiens_hsa006200.32823735
170Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30574678
171Basal transcription factors_Homo sapiens_hsa030220.30027833
172Malaria_Homo sapiens_hsa051440.27309949
173Primary bile acid biosynthesis_Homo sapiens_hsa001200.26832625
174Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26715574
175Vascular smooth muscle contraction_Homo sapiens_hsa042700.25673762
176Amphetamine addiction_Homo sapiens_hsa050310.25323136
177Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24699952
178Primary immunodeficiency_Homo sapiens_hsa053400.23868563
179Cocaine addiction_Homo sapiens_hsa050300.23647156
180Vitamin B6 metabolism_Homo sapiens_hsa007500.22288624
181Phototransduction_Homo sapiens_hsa047440.21643579
182Nucleotide excision repair_Homo sapiens_hsa034200.20812403
183Tryptophan metabolism_Homo sapiens_hsa003800.20581592
184Renin secretion_Homo sapiens_hsa049240.20417360
185Long-term depression_Homo sapiens_hsa047300.20237180
186Pertussis_Homo sapiens_hsa051330.19966267

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