BEX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.14829934
2regulation of posttranscriptional gene silencing (GO:0060147)5.07620021
3regulation of gene silencing by miRNA (GO:0060964)5.07620021
4regulation of gene silencing by RNA (GO:0060966)5.07620021
5synaptic vesicle maturation (GO:0016188)4.58685705
6nucleobase catabolic process (GO:0046113)4.44448395
7establishment of integrated proviral latency (GO:0075713)4.42522894
8neuron cell-cell adhesion (GO:0007158)4.38455355
9presynaptic membrane assembly (GO:0097105)4.32525017
10presynaptic membrane organization (GO:0097090)4.31447844
11histone arginine methylation (GO:0034969)4.26574661
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.24058636
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.21466134
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.18200450
15postsynaptic membrane organization (GO:0001941)4.14336734
16glutamate secretion (GO:0014047)4.04926428
17protein localization to synapse (GO:0035418)3.93447422
18maturation of SSU-rRNA (GO:0030490)3.90678517
19peptidyl-arginine omega-N-methylation (GO:0035247)3.87677213
20synaptic vesicle exocytosis (GO:0016079)3.85285054
21formation of translation preinitiation complex (GO:0001731)3.83856585
22nucleobase biosynthetic process (GO:0046112)3.83549289
23dendritic spine morphogenesis (GO:0060997)3.76805868
24neurotransmitter secretion (GO:0007269)3.72364333
25DNA replication initiation (GO:0006270)3.69817602
26cullin deneddylation (GO:0010388)3.67663839
27behavioral response to nicotine (GO:0035095)3.67118102
28neuronal action potential propagation (GO:0019227)3.66916174
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.66544838
30gamma-aminobutyric acid transport (GO:0015812)3.64217851
31axonal fasciculation (GO:0007413)3.63864025
32ribosomal small subunit biogenesis (GO:0042274)3.62305824
33purine nucleobase biosynthetic process (GO:0009113)3.61202100
34regulation of synaptic vesicle exocytosis (GO:2000300)3.60851360
35neuron recognition (GO:0008038)3.59891355
36synaptic transmission, glutamatergic (GO:0035249)3.59277254
37vocalization behavior (GO:0071625)3.57461438
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.57069794
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.54702313
40DNA unwinding involved in DNA replication (GO:0006268)3.53151318
41spliceosomal snRNP assembly (GO:0000387)3.48807681
42synaptic vesicle docking involved in exocytosis (GO:0016081)3.48315215
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.43825107
44negative regulation of synaptic transmission, GABAergic (GO:0032229)3.43742306
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43730123
46pre-miRNA processing (GO:0031054)3.43673990
47DNA replication-dependent nucleosome organization (GO:0034723)3.42336723
48DNA replication-dependent nucleosome assembly (GO:0006335)3.42336723
49neurotransmitter-gated ion channel clustering (GO:0072578)3.42236550
50auditory behavior (GO:0031223)3.41617373
51ribosome biogenesis (GO:0042254)3.41318689
52ribonucleoprotein complex biogenesis (GO:0022613)3.40798399
53establishment of mitochondrion localization (GO:0051654)3.38760669
54regulation of synapse structural plasticity (GO:0051823)3.38119503
55neuron-neuron synaptic transmission (GO:0007270)3.37233264
56DNA strand elongation involved in DNA replication (GO:0006271)3.35725534
57peptidyl-arginine N-methylation (GO:0035246)3.35538636
58peptidyl-arginine methylation (GO:0018216)3.35538636
59mitotic metaphase plate congression (GO:0007080)3.34660535
60ATP synthesis coupled proton transport (GO:0015986)3.33836648
61energy coupled proton transport, down electrochemical gradient (GO:0015985)3.33836648
62regulation of helicase activity (GO:0051095)3.32890922
63glutamate receptor signaling pathway (GO:0007215)3.32705458
64ribosomal small subunit assembly (GO:0000028)3.30875128
65viral transcription (GO:0019083)3.30840542
66ribosomal large subunit biogenesis (GO:0042273)3.30512244
67establishment of viral latency (GO:0019043)3.30035064
68spliceosomal complex assembly (GO:0000245)3.27119287
69translational termination (GO:0006415)3.26716316
70IMP biosynthetic process (GO:0006188)3.25394788
71protein deneddylation (GO:0000338)3.24229378
72synapse assembly (GO:0007416)3.23817221
73regulation of synaptic vesicle transport (GO:1902803)3.22608446
74paraxial mesoderm development (GO:0048339)3.21701073
75exploration behavior (GO:0035640)3.18535838
76somatic diversification of immune receptors via somatic mutation (GO:0002566)3.17905394
77somatic hypermutation of immunoglobulin genes (GO:0016446)3.17905394
78DNA strand elongation (GO:0022616)3.16353685
79ribosome assembly (GO:0042255)3.16337579
80histone H4-K12 acetylation (GO:0043983)3.13911940
81transmission of nerve impulse (GO:0019226)3.11348492
82DNA replication checkpoint (GO:0000076)3.09152715
83locomotory exploration behavior (GO:0035641)3.05856181
84mitotic sister chromatid segregation (GO:0000070)3.05328821
85telomere maintenance via semi-conservative replication (GO:0032201)3.03702989
86neurofilament cytoskeleton organization (GO:0060052)3.03239258
87translational initiation (GO:0006413)3.03096928
88regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.02908924
89chromatin remodeling at centromere (GO:0031055)3.01884180
90nuclear pore organization (GO:0006999)3.01460420
91regulation of nuclear cell cycle DNA replication (GO:0033262)3.01026936
92folic acid-containing compound biosynthetic process (GO:0009396)3.00325194
93nodal signaling pathway (GO:0038092)2.99996623
94positive regulation of synapse assembly (GO:0051965)2.99665920
95translational elongation (GO:0006414)2.99042833
96startle response (GO:0001964)2.98603890
97rRNA processing (GO:0006364)2.97473648
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97146089
99detection of calcium ion (GO:0005513)2.96345597
100cell migration in hindbrain (GO:0021535)2.95842737
101proteasome assembly (GO:0043248)2.94371899
102CENP-A containing nucleosome assembly (GO:0034080)2.93303684
103neurotransmitter transport (GO:0006836)2.91870821
104negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91161445
105kinetochore assembly (GO:0051382)2.90346248
106pseudouridine synthesis (GO:0001522)2.90172401
107positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.88965679
108nonmotile primary cilium assembly (GO:0035058)2.88781430
109regulation of neurotransmitter levels (GO:0001505)2.88307513
110metaphase plate congression (GO:0051310)2.87615322
111rRNA metabolic process (GO:0016072)2.87148660
112mitotic nuclear envelope disassembly (GO:0007077)2.86778977
113transcription-coupled nucleotide-excision repair (GO:0006283)2.86772722
114nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86064949
115rRNA modification (GO:0000154)2.85720267
116glycerophospholipid catabolic process (GO:0046475)2.85718663
117protein localization to kinetochore (GO:0034501)2.84296377
118neuromuscular synaptic transmission (GO:0007274)2.83481645
119negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83229584
120glycosphingolipid biosynthetic process (GO:0006688)2.83179160
121mechanosensory behavior (GO:0007638)2.82466865
122regulation of telomere maintenance via telomerase (GO:0032210)2.82226054
123negative regulation of cytosolic calcium ion concentration (GO:0051481)2.81522586
124regulation of vesicle fusion (GO:0031338)2.81364989
125viral mRNA export from host cell nucleus (GO:0046784)2.81021686
126G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.80985528
127kinetochore organization (GO:0051383)2.79798410
128cellular component biogenesis (GO:0044085)2.79158280
129neuronal ion channel clustering (GO:0045161)2.78455472
130anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.77692904
131retinal ganglion cell axon guidance (GO:0031290)2.76459058
132cellular protein complex disassembly (GO:0043624)2.76334972
133response to auditory stimulus (GO:0010996)2.74772641
1347-methylguanosine mRNA capping (GO:0006370)2.74463842
135telomere maintenance via telomere lengthening (GO:0010833)2.74355272
136maturation of 5.8S rRNA (GO:0000460)2.74122779
137regulation of postsynaptic membrane potential (GO:0060078)2.73164631
138transcription elongation from RNA polymerase III promoter (GO:0006385)2.72566650
139termination of RNA polymerase III transcription (GO:0006386)2.72566650
140tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.72391173
141RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.72391173
142mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.71672903
1437-methylguanosine RNA capping (GO:0009452)2.71344115
144RNA capping (GO:0036260)2.71344115
145regulation of excitatory postsynaptic membrane potential (GO:0060079)2.70529209
146negative regulation of androgen receptor signaling pathway (GO:0060766)2.70377252
147regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70042530
148DNA replication-independent nucleosome organization (GO:0034724)2.69664750
149DNA replication-independent nucleosome assembly (GO:0006336)2.69664750
150regulation of respiratory system process (GO:0044065)2.69642370
151positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.69160513
152positive regulation of membrane potential (GO:0045838)2.68192172
153viral life cycle (GO:0019058)2.65894469
154membrane depolarization during action potential (GO:0086010)2.65659879
155regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.65653479
156membrane disassembly (GO:0030397)2.65123572
157nuclear envelope disassembly (GO:0051081)2.65123572
158synapse organization (GO:0050808)2.64983280
159SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.64975273
160IMP metabolic process (GO:0046040)2.64818742
161histone H2A acetylation (GO:0043968)2.64710703
162protein localization to cilium (GO:0061512)2.64301235
163negative regulation of chromosome segregation (GO:0051985)2.63745076
164RNA splicing, via transesterification reactions (GO:0000375)2.63608698
165substrate-independent telencephalic tangential migration (GO:0021826)2.63461889
166substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.63461889
167translation (GO:0006412)2.62998613
168histone exchange (GO:0043486)2.62723105
169cotranslational protein targeting to membrane (GO:0006613)2.62378114
170regulation of glutamate receptor signaling pathway (GO:1900449)2.61824932
171adult walking behavior (GO:0007628)2.61164653
172regulation of neuronal synaptic plasticity (GO:0048168)2.61055742
173adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.61014999
174telomere maintenance via recombination (GO:0000722)2.60782454
175mRNA splicing, via spliceosome (GO:0000398)2.60488647
176RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.60488647
177neuronal action potential (GO:0019228)2.60079568
178regulation of neurotransmitter transport (GO:0051588)2.59942049
179regulation of neurotransmitter uptake (GO:0051580)2.59570488
180calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.58087155
181synaptic vesicle endocytosis (GO:0048488)2.57187498
182positive regulation of dendritic spine morphogenesis (GO:0061003)2.57025843
183regulation of synaptic transmission, glutamatergic (GO:0051966)2.56158631
184short-term memory (GO:0007614)2.56051485
185positive regulation of neurotransmitter transport (GO:0051590)2.55283152
186regulation of neurotransmitter secretion (GO:0046928)2.54604453
187dendrite morphogenesis (GO:0048813)2.53004569
188synaptic transmission (GO:0007268)2.52480404
189membrane hyperpolarization (GO:0060081)2.52214515
190regulation of calcium ion-dependent exocytosis (GO:0017158)2.51243861
191membrane depolarization (GO:0051899)2.49773089
192adult behavior (GO:0030534)2.49763721
193positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.49337554
194mitochondrion transport along microtubule (GO:0047497)2.48855281
195establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.48855281
196regulation of dendritic spine morphogenesis (GO:0061001)2.47522656
197positive regulation of dendritic spine development (GO:0060999)2.46616862
198establishment of synaptic vesicle localization (GO:0097480)2.44640290
199synaptic vesicle transport (GO:0048489)2.44640290
200serotonin metabolic process (GO:0042428)2.44270433

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.14995766
2EZH2_22144423_ChIP-Seq_EOC_Human4.55776505
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.51639275
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.47422434
5GBX2_23144817_ChIP-Seq_PC3_Human3.24779987
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12976715
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.04234817
8MYC_19030024_ChIP-ChIP_MESCs_Mouse3.00340496
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.97183360
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.97029293
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.92154680
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81218972
13REST_21632747_ChIP-Seq_MESCs_Mouse2.71231796
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69490930
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.68924886
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.68749382
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.53825926
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.51915109
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.51822021
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51601446
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.49664588
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.49664588
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.49664588
24ZNF274_21170338_ChIP-Seq_K562_Hela2.40543315
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38564767
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.33477891
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30792635
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.29936630
29XRN2_22483619_ChIP-Seq_HELA_Human2.29519790
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.28387873
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27787754
32IGF1R_20145208_ChIP-Seq_DFB_Human2.26399495
33TAF15_26573619_Chip-Seq_HEK293_Human2.26331948
34EZH2_27304074_Chip-Seq_ESCs_Mouse2.25306174
35THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24962274
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.22743069
37NANOG_18555785_ChIP-Seq_MESCs_Mouse2.21960590
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21157728
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19591879
40JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19127005
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.15875074
42CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15661128
43CBX2_27304074_Chip-Seq_ESCs_Mouse2.14380380
44E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13673262
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.12226730
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.09577882
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07687846
48NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.07560300
49SOX2_18555785_ChIP-Seq_MESCs_Mouse2.03232154
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02755241
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.01277645
52POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00376556
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.97016656
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96104514
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94660641
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93427717
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92821778
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.91992945
59RNF2_27304074_Chip-Seq_NSC_Mouse1.89812910
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89680718
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.89601000
62TTF2_22483619_ChIP-Seq_HELA_Human1.89467270
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.89192393
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88836641
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86454733
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83442140
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78703770
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.77897281
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77857857
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77327889
71P300_19829295_ChIP-Seq_ESCs_Human1.74493795
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.73685101
73SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.72805137
74JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71491263
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70930330
76VDR_22108803_ChIP-Seq_LS180_Human1.69604268
77VDR_23849224_ChIP-Seq_CD4+_Human1.68300114
78* FUS_26573619_Chip-Seq_HEK293_Human1.68266531
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67678185
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67288319
81TCF3_18692474_ChIP-Seq_MESCs_Mouse1.66746851
82DCP1A_22483619_ChIP-Seq_HELA_Human1.64526467
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.64054065
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.64035885
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61879189
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61500825
87EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61210446
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61210446
89GABP_19822575_ChIP-Seq_HepG2_Human1.60185586
90NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.59925222
91SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59520856
92RNF2_27304074_Chip-Seq_ESCs_Mouse1.58047794
93RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55683306
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.54718370
95SMAD4_21799915_ChIP-Seq_A2780_Human1.54577689
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53212178
97FOXP3_21729870_ChIP-Seq_TREG_Human1.50368380
98MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49905614
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49789380
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44670173
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44045405
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42744079
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42275301
104SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42196442
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37367271
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36136589
107RARB_27405468_Chip-Seq_BRAIN_Mouse1.35994808
108ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35955471
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.35449499
110EWS_26573619_Chip-Seq_HEK293_Human1.35092106
111SOX2_18692474_ChIP-Seq_MEFs_Mouse1.34906669
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.34550893
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34512876
114ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32435334
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31394371
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30423578
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30338066
118OCT4_18692474_ChIP-Seq_MEFs_Mouse1.29962099
119AR_25329375_ChIP-Seq_VCAP_Human1.29711149
120POU5F1_16518401_ChIP-PET_MESCs_Mouse1.29320012
121SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29113972
122E2F1_21310950_ChIP-Seq_MCF-7_Human1.29057901
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28621710
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28001112
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27842316
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27777781
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27112049
128DROSHA_22980978_ChIP-Seq_HELA_Human1.26576510
129RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26554217
130CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26505119
131ELK1_19687146_ChIP-ChIP_HELA_Human1.26244264
132PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24686012
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23617387
134AR_21909140_ChIP-Seq_LNCAP_Human1.22575582
135PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21619568
136MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21525825
137FLI1_27457419_Chip-Seq_LIVER_Mouse1.21008841
138NANOG_21062744_ChIP-ChIP_HESCs_Human1.20230495
139UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20005151
140SOX2_16153702_ChIP-ChIP_HESCs_Human1.19704851
141POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18142373
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18142373
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17740687
144IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17552358
145STAT3_23295773_ChIP-Seq_U87_Human1.17036575
146ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14893071
147NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13395452
148CBP_20019798_ChIP-Seq_JUKART_Human1.13321984
149IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13321984
150SOX2_18692474_ChIP-Seq_MESCs_Mouse1.13184848
151SRF_21415370_ChIP-Seq_HL-1_Mouse1.11370854
152TCF4_23295773_ChIP-Seq_U87_Human1.11136894
153POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.10538783
154SOX2_21211035_ChIP-Seq_LN229_Gbm1.10242424
155RING1B_27294783_Chip-Seq_ESCs_Mouse1.10144884
156TP53_22573176_ChIP-Seq_HFKS_Human1.09999113
157NANOG_16153702_ChIP-ChIP_HESCs_Human1.09817479
158BCAT_22108803_ChIP-Seq_LS180_Human1.09299219
159NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09133830
160NANOG_18555785_Chip-Seq_ESCs_Mouse1.08776182
161NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08638175
162GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07731484
163SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07141889
164KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06524920
165KDM5A_27292631_Chip-Seq_BREAST_Human1.06499463
166NANOG_18692474_ChIP-Seq_MEFs_Mouse1.06437551
167TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06129038
168RUNX2_22187159_ChIP-Seq_PCA_Human1.04984570
169TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03295343
170ER_23166858_ChIP-Seq_MCF-7_Human1.03249830
171ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03167519
172JUN_21703547_ChIP-Seq_K562_Human1.00949522
173CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99759199
174CIITA_25753668_ChIP-Seq_RAJI_Human0.99632551
175MYC_18940864_ChIP-ChIP_HL60_Human0.99485351
176PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99317506
177NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98815374
178PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98795472
179KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98751820
180TAL1_26923725_Chip-Seq_HPCs_Mouse0.98513141
181POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97617671
182KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96891037
183ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96754574
184EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96610041
185HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96254620
186ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94876692
187RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94568164
188LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94044163
189TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93743077
190SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93105854
191AR_21572438_ChIP-Seq_LNCaP_Human0.92767595
192P53_22387025_ChIP-Seq_ESCs_Mouse0.92058319
193CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91295056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting4.03830042
2MP0004859_abnormal_synaptic_plasticity3.59347808
3MP0003693_abnormal_embryo_hatching3.30380549
4MP0004957_abnormal_blastocyst_morpholog3.26011422
5MP0004133_heterotaxia3.25878241
6MP0003122_maternal_imprinting3.19583483
7MP0003121_genomic_imprinting2.98492684
8MP0010094_abnormal_chromosome_stability2.79229589
9MP0003111_abnormal_nucleus_morphology2.70413769
10MP0008057_abnormal_DNA_replication2.68692728
11MP0003077_abnormal_cell_cycle2.61740634
12MP0006292_abnormal_olfactory_placode2.58269572
13MP0008058_abnormal_DNA_repair2.45149391
14MP0002272_abnormal_nervous_system2.43311632
15MP0002064_seizures2.37941677
16MP0001984_abnormal_olfaction2.34513679
17MP0003890_abnormal_embryonic-extraembry2.32844920
18MP0008877_abnormal_DNA_methylation2.32229742
19MP0003119_abnormal_digestive_system2.29044705
20MP0008932_abnormal_embryonic_tissue2.16072723
21MP0002653_abnormal_ependyma_morphology2.06041929
22MP0001486_abnormal_startle_reflex2.02302655
23MP0002909_abnormal_adrenal_gland1.97072066
24MP0010030_abnormal_orbit_morphology1.97026062
25MP0002736_abnormal_nociception_after1.95186941
26MP0002735_abnormal_chemical_nociception1.92523827
27MP0001730_embryonic_growth_arrest1.91301124
28MP0003283_abnormal_digestive_organ1.79821083
29MP0002557_abnormal_social/conspecific_i1.78858256
30MP0005645_abnormal_hypothalamus_physiol1.78453084
31MP0001529_abnormal_vocalization1.74337099
32MP0001970_abnormal_pain_threshold1.72870979
33MP0003941_abnormal_skin_development1.71569430
34MP0002102_abnormal_ear_morphology1.68394511
35MP0003787_abnormal_imprinting1.67800441
36MP0002733_abnormal_thermal_nociception1.67658482
37MP0005646_abnormal_pituitary_gland1.62980392
38MP0000350_abnormal_cell_proliferation1.59838619
39MP0002084_abnormal_developmental_patter1.56430227
40MP0003315_abnormal_perineum_morphology1.55806383
41MP0008007_abnormal_cellular_replicative1.52670302
42MP0002067_abnormal_sensory_capabilities1.51976494
43MP0004885_abnormal_endolymph1.51596006
44MP0000955_abnormal_spinal_cord1.50454745
45MP0001697_abnormal_embryo_size1.50256356
46MP0002085_abnormal_embryonic_tissue1.48836578
47MP0005551_abnormal_eye_electrophysiolog1.47775135
48MP0005386_behavior/neurological_phenoty1.47375859
49MP0004924_abnormal_behavior1.47375859
50MP0002837_dystrophic_cardiac_calcinosis1.46977034
51MP0001672_abnormal_embryogenesis/_devel1.46927995
52MP0005380_embryogenesis_phenotype1.46927995
53MP0001501_abnormal_sleep_pattern1.45570418
54MP0001293_anophthalmia1.44227966
55MP0004811_abnormal_neuron_physiology1.42669853
56MP0006072_abnormal_retinal_apoptosis1.40547074
57MP0000537_abnormal_urethra_morphology1.40310832
58MP0002882_abnormal_neuron_morphology1.35690790
59MP0004197_abnormal_fetal_growth/weight/1.35239505
60MP0003880_abnormal_central_pattern1.31720151
61MP0010386_abnormal_urinary_bladder1.30949549
62MP0006276_abnormal_autonomic_nervous1.27388995
63MP0001188_hyperpigmentation1.27026544
64MP0009379_abnormal_foot_pigmentation1.26467722
65MP0005423_abnormal_somatic_nervous1.25039799
66MP0003718_maternal_effect1.24821948
67MP0003984_embryonic_growth_retardation1.23543944
68MP0002088_abnormal_embryonic_growth/wei1.22150703
69MP0003786_premature_aging1.20421213
70MP0006035_abnormal_mitochondrial_morpho1.20259630
71MP0003861_abnormal_nervous_system1.19754979
72MP0001986_abnormal_taste_sensitivity1.19206724
73MP0002080_prenatal_lethality1.19193334
74MP0002751_abnormal_autonomic_nervous1.16980977
75MP0003011_delayed_dark_adaptation1.16661588
76MP0002066_abnormal_motor_capabilities/c1.14113366
77MP0005253_abnormal_eye_physiology1.12906771
78MP0000049_abnormal_middle_ear1.11912100
79MP0002086_abnormal_extraembryonic_tissu1.10882556
80MP0005394_taste/olfaction_phenotype1.10878998
81MP0005499_abnormal_olfactory_system1.10878998
82MP0003567_abnormal_fetal_cardiomyocyte1.09443886
83MP0003879_abnormal_hair_cell1.08923884
84MP0002160_abnormal_reproductive_system1.08794456
85MP0002127_abnormal_cardiovascular_syste1.08035005
86MP0001502_abnormal_circadian_rhythm1.06380943
87MP0003633_abnormal_nervous_system1.05221739
88MP0004742_abnormal_vestibular_system1.03769558
89MP0009780_abnormal_chondrocyte_physiolo1.01912970
90MP0002752_abnormal_somatic_nervous1.01300870
91MP0002229_neurodegeneration1.00874695
92MP0002876_abnormal_thyroid_physiology1.00559824
93MP0005084_abnormal_gallbladder_morpholo1.00259132
94MP0001286_abnormal_eye_development0.99739062
95MP0008789_abnormal_olfactory_epithelium0.98626972
96MP0000631_abnormal_neuroendocrine_gland0.98574849
97MP0008569_lethality_at_weaning0.98410626
98MP0003806_abnormal_nucleotide_metabolis0.98037852
99MP0001485_abnormal_pinna_reflex0.96374979
100MP0003937_abnormal_limbs/digits/tail_de0.96269889
101MP0008995_early_reproductive_senescence0.94804075
102MP0002069_abnormal_eating/drinking_beha0.94502129
103MP0003136_yellow_coat_color0.94267931
104MP0000516_abnormal_urinary_system0.91780510
105MP0005367_renal/urinary_system_phenotyp0.91780510
106MP0004142_abnormal_muscle_tone0.91270226
107MP0002111_abnormal_tail_morphology0.90531233
108MP0005379_endocrine/exocrine_gland_phen0.90050233
109MP0002210_abnormal_sex_determination0.89807143
110MP0001963_abnormal_hearing_physiology0.87364393
111MP0004233_abnormal_muscle_weight0.87280223
112MP0002184_abnormal_innervation0.86963901
113MP0003631_nervous_system_phenotype0.86414490
114MP0003635_abnormal_synaptic_transmissio0.85634887
115MP0004264_abnormal_extraembryonic_tissu0.84481510
116MP0002572_abnormal_emotion/affect_behav0.83983235
117MP0000778_abnormal_nervous_system0.83288191
118MP0002152_abnormal_brain_morphology0.83273814
119MP0002822_catalepsy0.83229464
120MP0001145_abnormal_male_reproductive0.82285271
121MP0002249_abnormal_larynx_morphology0.81251418
122MP0000026_abnormal_inner_ear0.80644192
123MP0000639_abnormal_adrenal_gland0.80066491
124MP0009053_abnormal_anal_canal0.79485593
125MP0000313_abnormal_cell_death0.79272733
126MP0002638_abnormal_pupillary_reflex0.78133006
127MP0001905_abnormal_dopamine_level0.77990077
128MP0002938_white_spotting0.77357330
129MP0005187_abnormal_penis_morphology0.77105826
130MP0002063_abnormal_learning/memory/cond0.77061026
131MP0000358_abnormal_cell_content/0.76912944
132MP0010352_gastrointestinal_tract_polyps0.76480966
133MP0001944_abnormal_pancreas_morphology0.75952674
134MP0009672_abnormal_birth_weight0.75939792
135MP0000678_abnormal_parathyroid_gland0.75747322
136MP0002734_abnormal_mechanical_nocicepti0.75531779
137MP0003329_amyloid_beta_deposits0.74272343
138MP0009046_muscle_twitch0.74134756
139MP0004270_analgesia0.73874863
140MP0002090_abnormal_vision0.73616577
141MP0000569_abnormal_digit_pigmentation0.73438386
142MP0009745_abnormal_behavioral_response0.73234420
143MP0003195_calcinosis0.72935102
144MP0008872_abnormal_physiological_respon0.72881245
145MP0004147_increased_porphyrin_level0.71387714
146MP0004145_abnormal_muscle_electrophysio0.71278620
147MP0003942_abnormal_urinary_system0.70808824
148MP0003755_abnormal_palate_morphology0.70366981
149MP0005195_abnormal_posterior_eye0.70314861
150MP0002928_abnormal_bile_duct0.69781144
151MP0005389_reproductive_system_phenotype0.69518744
152MP0002163_abnormal_gland_morphology0.69478312
153MP0001968_abnormal_touch/_nociception0.69464614
154MP0002697_abnormal_eye_size0.69281009
155MP0009703_decreased_birth_body0.68344353
156MP0003938_abnormal_ear_development0.67487508
157MP0004085_abnormal_heartbeat0.67312827
158MP0002081_perinatal_lethality0.67209257
159MP0001440_abnormal_grooming_behavior0.66959424

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.93977359
2Abnormality of the labia minora (HP:0012880)4.41941081
3Focal motor seizures (HP:0011153)4.30183108
4Supernumerary spleens (HP:0009799)3.96620373
5Polyphagia (HP:0002591)3.96345539
6Focal seizures (HP:0007359)3.66860925
7Birth length less than 3rd percentile (HP:0003561)3.62907844
8Ependymoma (HP:0002888)3.55722883
9Febrile seizures (HP:0002373)3.40177953
10Atonic seizures (HP:0010819)3.35818764
11Gait imbalance (HP:0002141)3.34252974
12Epileptic encephalopathy (HP:0200134)3.29968738
13Colon cancer (HP:0003003)3.18152914
14Breast hypoplasia (HP:0003187)3.13118168
15Medial flaring of the eyebrow (HP:0010747)3.12999417
16Absent radius (HP:0003974)3.07960568
17Abdominal situs inversus (HP:0003363)3.07075008
18Abnormality of abdominal situs (HP:0011620)3.07075008
19Hyperventilation (HP:0002883)3.05687999
20Epileptiform EEG discharges (HP:0011182)3.00637973
21Progressive cerebellar ataxia (HP:0002073)2.96697484
22Absent forearm bone (HP:0003953)2.96300524
23Aplasia involving forearm bones (HP:0009822)2.96300524
24EEG with generalized epileptiform discharges (HP:0011198)2.93824605
25Dialeptic seizures (HP:0011146)2.90258395
26Hypsarrhythmia (HP:0002521)2.88511470
27Congenital primary aphakia (HP:0007707)2.86199277
28Medulloblastoma (HP:0002885)2.84225590
29Abnormal eating behavior (HP:0100738)2.84105996
30Acute necrotizing encephalopathy (HP:0006965)2.82123151
31Absence seizures (HP:0002121)2.79622869
32Drooling (HP:0002307)2.78354807
33Generalized tonic-clonic seizures (HP:0002069)2.76060214
34Aplasia/hypoplasia of the humerus (HP:0006507)2.75621587
35Agitation (HP:0000713)2.75362212
36Hemiparesis (HP:0001269)2.72911589
37Nephrogenic diabetes insipidus (HP:0009806)2.72438435
38Patellar aplasia (HP:0006443)2.72114673
39Carpal bone hypoplasia (HP:0001498)2.70290570
40True hermaphroditism (HP:0010459)2.68820594
41Reticulocytopenia (HP:0001896)2.67359401
42Poor suck (HP:0002033)2.67138155
43Abnormal number of incisors (HP:0011064)2.64883792
44Abnormality of the corticospinal tract (HP:0002492)2.58689383
45Broad-based gait (HP:0002136)2.58394061
46Action tremor (HP:0002345)2.57823876
47Failure to thrive in infancy (HP:0001531)2.53793142
48Oral leukoplakia (HP:0002745)2.53339040
49Aplasia/Hypoplasia of the patella (HP:0006498)2.51269197
50Absent thumb (HP:0009777)2.51216320
51Pancreatic fibrosis (HP:0100732)2.51033061
52Excessive salivation (HP:0003781)2.50626202
53Abnormal mitochondria in muscle tissue (HP:0008316)2.49953685
54Hypothermia (HP:0002045)2.49084734
55Lissencephaly (HP:0001339)2.48616594
56Astrocytoma (HP:0009592)2.47804611
57Abnormality of the astrocytes (HP:0100707)2.47804611
58Rib fusion (HP:0000902)2.46969871
59Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.46235215
60Impaired vibration sensation in the lower limbs (HP:0002166)2.45358359
61Genital tract atresia (HP:0001827)2.44877481
62Cerebral hypomyelination (HP:0006808)2.43547807
63Missing ribs (HP:0000921)2.42879447
64Nephronophthisis (HP:0000090)2.41974801
65Selective tooth agenesis (HP:0001592)2.41117843
66Vaginal atresia (HP:0000148)2.40834466
67Molar tooth sign on MRI (HP:0002419)2.40688758
68Abnormality of midbrain morphology (HP:0002418)2.40688758
69Pancreatic cysts (HP:0001737)2.36421394
70Short humerus (HP:0005792)2.35652494
71Degeneration of the lateral corticospinal tracts (HP:0002314)2.34571050
72Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.34571050
73Rectovaginal fistula (HP:0000143)2.28396329
74Rectal fistula (HP:0100590)2.28396329
75Abnormal lung lobation (HP:0002101)2.28132592
76Specific learning disability (HP:0001328)2.27213140
77Spastic tetraplegia (HP:0002510)2.26244911
78Abnormality of glycolysis (HP:0004366)2.26157907
79Increased serum pyruvate (HP:0003542)2.26157907
80Shawl scrotum (HP:0000049)2.23430227
81Abnormality of cells of the erythroid lineage (HP:0012130)2.22012853
82Amblyopia (HP:0000646)2.21385864
83Asplenia (HP:0001746)2.21038377
84Rhabdomyosarcoma (HP:0002859)2.18812437
85Progressive macrocephaly (HP:0004481)2.16677806
86Facial cleft (HP:0002006)2.16152765
87Septo-optic dysplasia (HP:0100842)2.15111508
88Type II lissencephaly (HP:0007260)2.14372549
89Stenosis of the external auditory canal (HP:0000402)2.13577173
90Pachygyria (HP:0001302)2.13258465
91Aplasia/Hypoplasia of the sternum (HP:0006714)2.11884099
92Mitochondrial inheritance (HP:0001427)2.11417311
93Anophthalmia (HP:0000528)2.10887622
94Abnormality of the anterior horn cell (HP:0006802)2.09618337
95Degeneration of anterior horn cells (HP:0002398)2.09618337
96Muscular hypotonia of the trunk (HP:0008936)2.09599244
97Sleep apnea (HP:0010535)2.08526595
98Breast aplasia (HP:0100783)2.08093031
99Horseshoe kidney (HP:0000085)2.06573262
100Glioma (HP:0009733)2.06486098
101Aplasia/Hypoplasia of the spleen (HP:0010451)2.05116311
102Increased CSF lactate (HP:0002490)2.04875834
103Agnosia (HP:0010524)2.04680318
104Spastic gait (HP:0002064)2.04456396
105Intestinal atresia (HP:0011100)2.04148701
106High anterior hairline (HP:0009890)2.02457567
107Acute encephalopathy (HP:0006846)2.02425730
108Meckel diverticulum (HP:0002245)2.02254195
109Neoplasm of the oral cavity (HP:0100649)2.01895485
110Abnormality of the ileum (HP:0001549)2.00683797
111Double outlet right ventricle (HP:0001719)1.99757020
112Congenital malformation of the right heart (HP:0011723)1.99757020
113Nephroblastoma (Wilms tumor) (HP:0002667)1.99622908
114Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98912295
115Trismus (HP:0000211)1.98871741
116Gaze-evoked nystagmus (HP:0000640)1.98158487
117Ankle clonus (HP:0011448)1.98107515
118Hyperglycinemia (HP:0002154)1.96226762
119Poor coordination (HP:0002370)1.95664731
120Anxiety (HP:0000739)1.95077579
121Esotropia (HP:0000565)1.93364071
122Urinary urgency (HP:0000012)1.93351250
123Limb dystonia (HP:0002451)1.92276937
124Chromsome breakage (HP:0040012)1.92229333
125Status epilepticus (HP:0002133)1.91659605
126Impulsivity (HP:0100710)1.91576892
127Macrocytic anemia (HP:0001972)1.90853904
128Embryonal renal neoplasm (HP:0011794)1.90679731
129Bilateral microphthalmos (HP:0007633)1.90590182
130Intestinal fistula (HP:0100819)1.90353675
131Abnormality of the lower motor neuron (HP:0002366)1.89386732
132Esophageal atresia (HP:0002032)1.89084932
133Oligodactyly (hands) (HP:0001180)1.88714722
134Increased hepatocellular lipid droplets (HP:0006565)1.87184827
13511 pairs of ribs (HP:0000878)1.86987984
136Retinal dysplasia (HP:0007973)1.86804800
137Aplasia/Hypoplasia of the breasts (HP:0010311)1.86454095
138Absent speech (HP:0001344)1.86434372
139Abnormal hair whorl (HP:0010721)1.85921887
140Fused cervical vertebrae (HP:0002949)1.85900188
141Atrophy/Degeneration involving motor neurons (HP:0007373)1.85646964
1423-Methylglutaconic aciduria (HP:0003535)1.85487542
143Neoplasm of striated muscle (HP:0009728)1.84667443
144Inability to walk (HP:0002540)1.83954157
145Abnormal ventriculo-arterial connection (HP:0011563)1.83395611
146Transposition of the great arteries (HP:0001669)1.83395611
147Abnormal connection of the cardiac segments (HP:0011545)1.83395611
148Methylmalonic acidemia (HP:0002912)1.83392654
149Abnormality of the renal medulla (HP:0100957)1.83107145
150Rough bone trabeculation (HP:0100670)1.82512544
151Anal stenosis (HP:0002025)1.82182627
152Hepatocellular necrosis (HP:0001404)1.81268792
153Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80893162
154Abnormal number of erythroid precursors (HP:0012131)1.80724641
155Hepatic necrosis (HP:0002605)1.80023955
156Vaginal fistula (HP:0004320)1.79007019
157Chronic hepatic failure (HP:0100626)1.78373677
158Urinary bladder sphincter dysfunction (HP:0002839)1.77801887
159Cellular immunodeficiency (HP:0005374)1.77706925
160Intention tremor (HP:0002080)1.77684564
161Lipid accumulation in hepatocytes (HP:0006561)1.77529954
162Adenoma sebaceum (HP:0009720)1.76935661
163Angiofibromas (HP:0010615)1.76935661
164Amyotrophic lateral sclerosis (HP:0007354)1.76235348
165Narrow forehead (HP:0000341)1.75960370
166Generalized myoclonic seizures (HP:0002123)1.75500024
167Male pseudohermaphroditism (HP:0000037)1.75437537
168Focal dystonia (HP:0004373)1.74526275
169Aplasia/Hypoplasia of the uvula (HP:0010293)1.74426578
170Triphalangeal thumb (HP:0001199)1.73469911
171Morphological abnormality of the pyramidal tract (HP:0002062)1.72649935
172Atresia of the external auditory canal (HP:0000413)1.72337193
173Abnormality of the preputium (HP:0100587)1.71555269
174Torticollis (HP:0000473)1.71543617
175Exercise intolerance (HP:0003546)1.71483566
176Gastrointestinal atresia (HP:0002589)1.69600575
177Cleft eyelid (HP:0000625)1.69209137
178Mutism (HP:0002300)1.69092557
179Hepatoblastoma (HP:0002884)1.68634598
180Tracheoesophageal fistula (HP:0002575)1.67939025
181Restlessness (HP:0000711)1.67255646
182Progressive external ophthalmoplegia (HP:0000590)1.67032588
183Premature ovarian failure (HP:0008209)1.67006116
184Neoplasm of the pancreas (HP:0002894)1.65717306
185Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.65609285
186Postaxial hand polydactyly (HP:0001162)1.65356221
187Hypoplasia of the brainstem (HP:0002365)1.64659974
188Aplasia/Hypoplasia of the brainstem (HP:0007362)1.64659974
189Optic nerve hypoplasia (HP:0000609)1.64145117
190Renal Fanconi syndrome (HP:0001994)1.63955350

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.25962432
2WEE13.55067715
3PNCK3.23130067
4CDC73.20177002
5MAP4K22.61267442
6SRPK12.57329834
7TSSK62.52806842
8MAP2K72.48235660
9NEK12.42494552
10PLK42.32048301
11EPHA42.25889693
12PINK12.22570865
13FRK2.13890827
14EPHA22.11772088
15AKT32.08643034
16DAPK22.03076050
17EIF2AK11.99555813
18PLK31.96875598
19TTK1.90820271
20CDK121.88826997
21PLK11.84699543
22PHKG21.74042146
23PHKG11.74042146
24CSNK1G21.72247710
25TNIK1.70419651
26RPS6KB21.69340597
27PAK31.63518764
28VRK11.61235515
29CDK71.49805502
30LATS21.49262900
31MARK11.45434435
32PASK1.44657122
33PAK61.44618148
34TRIM281.44396620
35NME11.41793910
36STK161.40119424
37AURKA1.37711692
38DYRK21.36853913
39STK38L1.34443665
40MAP3K91.34182650
41CDK191.31128199
42MAP2K41.31029108
43CSNK1G11.29690071
44BRAF1.27479384
45CHEK21.25733986
46MKNK11.23718141
47BRSK11.19822533
48DYRK31.19328855
49BRSK21.18986625
50CDK51.18228801
51AURKB1.13157359
52UHMK11.12485547
53MKNK21.11520338
54GRK11.10631976
55ATR1.10117073
56PRKCE1.09276100
57SIK21.09156064
58EPHA31.09078795
59CHEK11.08991432
60CSNK1A1L1.07075488
61NEK21.05650334
62BRD41.02874254
63EIF2AK31.02534436
64CAMK2A1.02291013
65DAPK11.02089559
66TLK11.01706146
67ALK1.00942341
68ERBB31.00849475
69FGFR21.00694131
70SGK2230.99253106
71SGK4940.99253106
72BCR0.99157955
73NTRK30.98670164
74PLK20.95831466
75PRKCI0.95686064
76CAMKK20.94612118
77WNK30.94306006
78LIMK10.92283439
79MAP3K40.90951565
80BMPR1B0.90379187
81CASK0.89737215
82TESK20.87611896
83CSNK1E0.85542534
84PAK40.85171823
85ARAF0.84667426
86WNK40.84585124
87CSNK2A20.83156952
88ACVR1B0.82989043
89CDK20.82785967
90PRKD30.81949494
91MINK10.81593551
92OXSR10.80196886
93INSRR0.77608434
94CAMK10.77074623
95ATM0.75990043
96MAP3K120.75551125
97CAMKK10.75078756
98MAPKAPK30.72578848
99CDK140.71244485
100CDK180.70369098
101PRKCZ0.70251005
102SGK20.68989448
103CSNK2A10.68643937
104CAMK2D0.68398444
105CDK11A0.67210991
106CDK150.66832463
107OBSCN0.66570361
108CDK10.66074612
109TGFBR10.66012332
110KSR10.65451205
111PKN10.65154522
112TESK10.64961855
113MAPK130.61933066
114STK110.61703556
115NME20.61168796
116AKT20.60964143
117PRKACA0.58779546
118MAP3K80.58065352
119NTRK10.57539728
120SCYL20.56212452
121PAK10.54357067
122CSNK1A10.54109511
123PRKG10.53074185
124CDK80.52172611
125NTRK20.51689015
126SGK10.51668555
127CAMK2G0.51082198
128GRK50.50810394
129CSNK1D0.49789942
130YES10.49018332
131CCNB10.47938342
132CAMK40.47206210
133TYRO30.47168241
134FGFR10.44964876
135PRKDC0.44628772
136DYRK1B0.44517585
137PRKCG0.43641371
138BCKDK0.42776204
139ADRBK20.42618818
140CDK30.42581830
141CSNK1G30.42400830
142PRKACB0.41845578
143CDK40.41781107
144PRKCH0.41521355
145RPS6KA30.40878644
146ZAK0.39892818
147ADRBK10.39365592
148MAP3K110.38496782
149PDK40.37833150
150PDK30.37833150
151PRKCA0.37563418
152CDC42BPA0.37544913
153PRKAA10.36972745
154DAPK30.36003300
155DYRK1A0.33531830
156GSK3B0.33276637
157TAOK10.33270906
158CAMK2B0.32602666
159PBK0.32400837
160CAMK1G0.32111942
161PRKCB0.30257450
162FER0.30089786
163RPS6KA50.29986844

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.95315528
2Ribosome_Homo sapiens_hsa030103.72908564
3DNA replication_Homo sapiens_hsa030303.64698894
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.50688917
5Proteasome_Homo sapiens_hsa030503.49822377
6RNA polymerase_Homo sapiens_hsa030203.46981054
7Spliceosome_Homo sapiens_hsa030403.31628807
8RNA transport_Homo sapiens_hsa030132.98525226
9Oxidative phosphorylation_Homo sapiens_hsa001902.60415064
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.54095778
11Nucleotide excision repair_Homo sapiens_hsa034202.50458900
12Parkinsons disease_Homo sapiens_hsa050122.48688588
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.39795460
14Homologous recombination_Homo sapiens_hsa034402.39269533
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27660497
16Pyrimidine metabolism_Homo sapiens_hsa002402.21334335
17Insulin secretion_Homo sapiens_hsa049112.21300169
18Huntingtons disease_Homo sapiens_hsa050162.20954048
19One carbon pool by folate_Homo sapiens_hsa006702.17555433
20Base excision repair_Homo sapiens_hsa034102.11627710
21Maturity onset diabetes of the young_Homo sapiens_hsa049502.05620486
22Cell cycle_Homo sapiens_hsa041101.99080325
23Butanoate metabolism_Homo sapiens_hsa006501.90841516
24mRNA surveillance pathway_Homo sapiens_hsa030151.89021613
25RNA degradation_Homo sapiens_hsa030181.84362086
26Fanconi anemia pathway_Homo sapiens_hsa034601.80597634
27Basal transcription factors_Homo sapiens_hsa030221.75608505
28Non-homologous end-joining_Homo sapiens_hsa034501.55755687
29Cardiac muscle contraction_Homo sapiens_hsa042601.53069652
30Alzheimers disease_Homo sapiens_hsa050101.50445543
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48160539
32Oocyte meiosis_Homo sapiens_hsa041141.40684107
33Purine metabolism_Homo sapiens_hsa002301.28114862
34Nicotine addiction_Homo sapiens_hsa050331.25377226
35Cholinergic synapse_Homo sapiens_hsa047251.18353312
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16730067
37Hedgehog signaling pathway_Homo sapiens_hsa043401.09410270
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08239182
39Olfactory transduction_Homo sapiens_hsa047401.08105315
40Basal cell carcinoma_Homo sapiens_hsa052171.07898268
41Gastric acid secretion_Homo sapiens_hsa049711.04180777
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00699916
43Salivary secretion_Homo sapiens_hsa049701.00160512
44Biosynthesis of amino acids_Homo sapiens_hsa012301.00103123
45Synaptic vesicle cycle_Homo sapiens_hsa047210.99920771
46Steroid biosynthesis_Homo sapiens_hsa001000.98508007
47p53 signaling pathway_Homo sapiens_hsa041150.96813923
48Hippo signaling pathway_Homo sapiens_hsa043900.96508273
49Propanoate metabolism_Homo sapiens_hsa006400.96458428
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95283789
51Axon guidance_Homo sapiens_hsa043600.94735031
52Renin secretion_Homo sapiens_hsa049240.93803213
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93798836
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92635098
55Vitamin B6 metabolism_Homo sapiens_hsa007500.91375645
56Ether lipid metabolism_Homo sapiens_hsa005650.90910562
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90494430
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.89380578
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88515800
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88118702
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85316513
62Regulation of autophagy_Homo sapiens_hsa041400.83025998
63Epstein-Barr virus infection_Homo sapiens_hsa051690.82562865
64cAMP signaling pathway_Homo sapiens_hsa040240.81503054
65Oxytocin signaling pathway_Homo sapiens_hsa049210.79464119
66Collecting duct acid secretion_Homo sapiens_hsa049660.78827665
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77947164
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76883194
69Calcium signaling pathway_Homo sapiens_hsa040200.76867641
70beta-Alanine metabolism_Homo sapiens_hsa004100.74357477
71Alcoholism_Homo sapiens_hsa050340.74055887
72Fatty acid elongation_Homo sapiens_hsa000620.73164584
73Nitrogen metabolism_Homo sapiens_hsa009100.69159523
74Peroxisome_Homo sapiens_hsa041460.68279854
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65431981
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64009659
77Tryptophan metabolism_Homo sapiens_hsa003800.63664045
78Vibrio cholerae infection_Homo sapiens_hsa051100.63009330
79Fructose and mannose metabolism_Homo sapiens_hsa000510.62793619
80Protein export_Homo sapiens_hsa030600.62068203
81Type II diabetes mellitus_Homo sapiens_hsa049300.62061350
82Linoleic acid metabolism_Homo sapiens_hsa005910.62056427
83Circadian rhythm_Homo sapiens_hsa047100.60382214
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60374671
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59327774
86Thyroid cancer_Homo sapiens_hsa052160.58880851
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58675012
88Amphetamine addiction_Homo sapiens_hsa050310.57713905
89Wnt signaling pathway_Homo sapiens_hsa043100.57642142
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56516153
91Tight junction_Homo sapiens_hsa045300.56438039
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55219418
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54119656
94TGF-beta signaling pathway_Homo sapiens_hsa043500.53414301
95Carbon metabolism_Homo sapiens_hsa012000.51981710
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51206651
97Dopaminergic synapse_Homo sapiens_hsa047280.50575162
98Galactose metabolism_Homo sapiens_hsa000520.50010483
99Systemic lupus erythematosus_Homo sapiens_hsa053220.49762292
100GABAergic synapse_Homo sapiens_hsa047270.47879271
101Long-term potentiation_Homo sapiens_hsa047200.47796198
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.46833877
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46614242
104Taste transduction_Homo sapiens_hsa047420.46535395
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45602174
106Melanogenesis_Homo sapiens_hsa049160.45409960
107Selenocompound metabolism_Homo sapiens_hsa004500.45339763
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.44701507
109Gap junction_Homo sapiens_hsa045400.42165891
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42008905
111Fatty acid metabolism_Homo sapiens_hsa012120.41962794
112Serotonergic synapse_Homo sapiens_hsa047260.41344587
113Thyroid hormone synthesis_Homo sapiens_hsa049180.40498288
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39632403
115Pancreatic secretion_Homo sapiens_hsa049720.39119036
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38480209
117Ovarian steroidogenesis_Homo sapiens_hsa049130.38406247
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.37557447
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37385279
120Arginine and proline metabolism_Homo sapiens_hsa003300.37332436
121Pyruvate metabolism_Homo sapiens_hsa006200.35653834
122Cocaine addiction_Homo sapiens_hsa050300.34677210
123Viral carcinogenesis_Homo sapiens_hsa052030.33896213
124Long-term depression_Homo sapiens_hsa047300.33684214
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31852317
126Metabolic pathways_Homo sapiens_hsa011000.31704860
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.31177087
128Fat digestion and absorption_Homo sapiens_hsa049750.31158626
129Phototransduction_Homo sapiens_hsa047440.30354469
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30089217
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29498337
132Melanoma_Homo sapiens_hsa052180.29338609
133Ras signaling pathway_Homo sapiens_hsa040140.29164446
134GnRH signaling pathway_Homo sapiens_hsa049120.28808102
135Mineral absorption_Homo sapiens_hsa049780.28469018
136Bladder cancer_Homo sapiens_hsa052190.28120246
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27783573
138Phenylalanine metabolism_Homo sapiens_hsa003600.27483434
139Colorectal cancer_Homo sapiens_hsa052100.25529628
140Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25135562
141HTLV-I infection_Homo sapiens_hsa051660.24963168
142HIF-1 signaling pathway_Homo sapiens_hsa040660.24469900
143Glucagon signaling pathway_Homo sapiens_hsa049220.23081221
144Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22367826
145Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22232171
146Morphine addiction_Homo sapiens_hsa050320.21763128
147Tyrosine metabolism_Homo sapiens_hsa003500.21305774
148Pathways in cancer_Homo sapiens_hsa052000.21129982
149Type I diabetes mellitus_Homo sapiens_hsa049400.20602942
150Circadian entrainment_Homo sapiens_hsa047130.20020214
151MicroRNAs in cancer_Homo sapiens_hsa052060.19569909
152Glutamatergic synapse_Homo sapiens_hsa047240.18747952
153Glutathione metabolism_Homo sapiens_hsa004800.18336331
154Folate biosynthesis_Homo sapiens_hsa007900.16942216
155Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16376149
156Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.16364479
157Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16352943
158Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.15835856

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