BHLHB9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a gene family which encodes proteins with a basic helix-loop-helix domain. Other members of this gene family encode proteins which function as transcription factors, either enhancing or inhibiting transcription depending on the activity of other DNA binding proteins. The coding region of this gene is located entirely within the terminal exon. The encoded protein may be involved in the survival of neurons (PMID: 15034937). Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.33109474
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.08530366
3locomotory exploration behavior (GO:0035641)5.04385107
4protein localization to synapse (GO:0035418)4.88917056
5pyrimidine nucleobase catabolic process (GO:0006208)4.86376613
6regulation of glutamate receptor signaling pathway (GO:1900449)4.81690597
7neuron cell-cell adhesion (GO:0007158)4.71899670
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.68802451
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.66411796
10vocalization behavior (GO:0071625)4.66242738
11synaptic vesicle exocytosis (GO:0016079)4.58989945
12regulation of synaptic vesicle exocytosis (GO:2000300)4.42071527
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.41624440
14synaptic vesicle maturation (GO:0016188)4.29050983
15exploration behavior (GO:0035640)4.24654760
16postsynaptic membrane organization (GO:0001941)4.17480149
17regulation of synapse structural plasticity (GO:0051823)4.08340135
18nucleobase catabolic process (GO:0046113)4.08067572
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.99595196
20regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.95821597
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.93869545
22neurotransmitter-gated ion channel clustering (GO:0072578)3.93843760
23glutamate secretion (GO:0014047)3.93321441
24synaptic transmission, glutamatergic (GO:0035249)3.82653133
25glutamate receptor signaling pathway (GO:0007215)3.82021840
26positive regulation of synaptic transmission, GABAergic (GO:0032230)3.75959577
27neurotransmitter secretion (GO:0007269)3.73968483
28positive regulation of synapse maturation (GO:0090129)3.73781122
29regulation of synaptic vesicle transport (GO:1902803)3.70703340
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.70230282
31gamma-aminobutyric acid transport (GO:0015812)3.67100910
32layer formation in cerebral cortex (GO:0021819)3.63960609
33axonal fasciculation (GO:0007413)3.62685368
34neuron recognition (GO:0008038)3.62635255
35regulation of neuronal synaptic plasticity (GO:0048168)3.56305952
36neuron-neuron synaptic transmission (GO:0007270)3.52181438
37G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.45970602
38cell communication by electrical coupling (GO:0010644)3.44265874
39proline transport (GO:0015824)3.40292531
40behavioral fear response (GO:0001662)3.40093720
41behavioral defense response (GO:0002209)3.40093720
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34162154
43innervation (GO:0060384)3.32918949
44nonmotile primary cilium assembly (GO:0035058)3.31780331
45behavioral response to nicotine (GO:0035095)3.29205168
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.26038318
47long-term memory (GO:0007616)3.25378612
48positive regulation of neurotransmitter secretion (GO:0001956)3.25209584
49regulation of postsynaptic membrane potential (GO:0060078)3.23719459
50auditory behavior (GO:0031223)3.22434703
51gamma-aminobutyric acid signaling pathway (GO:0007214)3.21739009
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.20492339
53regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.17877427
54response to pheromone (GO:0019236)3.14622828
55regulation of vesicle fusion (GO:0031338)3.14096589
56activation of protein kinase A activity (GO:0034199)3.14060041
57* positive regulation of dendritic spine morphogenesis (GO:0061003)3.13229410
58presynaptic membrane organization (GO:0097090)3.13220315
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.12914300
60fear response (GO:0042596)3.11473338
61dendritic spine morphogenesis (GO:0060997)3.11390096
62presynaptic membrane assembly (GO:0097105)3.10839246
63prepulse inhibition (GO:0060134)3.10308831
64negative regulation of cytosolic calcium ion concentration (GO:0051481)3.10065707
65positive regulation of membrane potential (GO:0045838)3.09939890
66cellular potassium ion homeostasis (GO:0030007)3.09007219
67substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.08308571
68substrate-independent telencephalic tangential migration (GO:0021826)3.08308571
69negative regulation of microtubule polymerization (GO:0031115)3.05835123
70positive regulation of neurotransmitter transport (GO:0051590)3.05283301
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04959706
72neuronal action potential propagation (GO:0019227)3.04195180
73central nervous system projection neuron axonogenesis (GO:0021952)3.02669510
74transmission of nerve impulse (GO:0019226)3.00472135
75regulation of synapse maturation (GO:0090128)2.98747628
76neuronal ion channel clustering (GO:0045161)2.96740315
77response to histamine (GO:0034776)2.96246900
78* positive regulation of synapse assembly (GO:0051965)2.96020773
79regulation of synaptic plasticity (GO:0048167)2.95294801
80cerebral cortex radially oriented cell migration (GO:0021799)2.94349154
81membrane hyperpolarization (GO:0060081)2.93894468
82limb bud formation (GO:0060174)2.91799539
83regulation of respiratory system process (GO:0044065)2.91524299
84regulation of neurotransmitter secretion (GO:0046928)2.91121585
85synapse assembly (GO:0007416)2.90756752
86neurotransmitter transport (GO:0006836)2.90268062
87sodium ion export (GO:0071436)2.89400166
88mechanosensory behavior (GO:0007638)2.88736831
89negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87906910
90learning (GO:0007612)2.87140293
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.85782072
92response to auditory stimulus (GO:0010996)2.79767694
93cerebellar Purkinje cell differentiation (GO:0021702)2.79006073
94cell migration in hindbrain (GO:0021535)2.78573814
95synaptic vesicle endocytosis (GO:0048488)2.77979307
96neuromuscular process controlling balance (GO:0050885)2.77297456
97positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.76352473
98* regulation of synapse organization (GO:0050807)2.74912519
99long-term synaptic potentiation (GO:0060291)2.74590243
100establishment of mitochondrion localization (GO:0051654)2.74356033
101* regulation of dendritic spine morphogenesis (GO:0061001)2.73303763
102startle response (GO:0001964)2.71085976
103regulation of neurotransmitter transport (GO:0051588)2.71001496
104dendrite morphogenesis (GO:0048813)2.69400826
105neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.67479913
106synapse organization (GO:0050808)2.67476455
107retinal cone cell development (GO:0046549)2.67403305
108membrane depolarization (GO:0051899)2.66470189
109nerve growth factor signaling pathway (GO:0038180)2.65898319
110regulation of cAMP-dependent protein kinase activity (GO:2000479)2.65434739
111cochlea development (GO:0090102)2.64547544
112DNA double-strand break processing (GO:0000729)2.63579248
113* regulation of synapse assembly (GO:0051963)2.63492392
114G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.62917276
115glycosphingolipid biosynthetic process (GO:0006688)2.55439608
116olfactory bulb development (GO:0021772)2.54102127
117protein localization to cilium (GO:0061512)2.51442476
118hippocampus development (GO:0021766)2.44116894
119regulation of timing of cell differentiation (GO:0048505)2.42350452
120negative regulation of transcription regulatory region DNA binding (GO:2000678)2.37861112
121retinal ganglion cell axon guidance (GO:0031290)2.36995169
122protein polyglutamylation (GO:0018095)2.35917516
123regulation of development, heterochronic (GO:0040034)2.35696797
124central nervous system neuron axonogenesis (GO:0021955)2.34493475
125histone H2A acetylation (GO:0043968)2.32436008
126epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.31949387
127C4-dicarboxylate transport (GO:0015740)2.31661966
128protein-cofactor linkage (GO:0018065)2.31623247
129adult walking behavior (GO:0007628)2.29150573
130atrial cardiac muscle cell action potential (GO:0086014)2.28323855
131serotonin metabolic process (GO:0042428)2.28268402
132calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.26716178
133regulation of telomere maintenance (GO:0032204)2.25849081
134regulation of sarcomere organization (GO:0060297)2.23564132
135intraciliary transport (GO:0042073)2.23410999
136cilium assembly (GO:0042384)2.23029109
137regulation of cilium movement (GO:0003352)2.22914899
138neuromuscular synaptic transmission (GO:0007274)2.22764036
139cilium organization (GO:0044782)2.22478648
140establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.21421413
141mitochondrion transport along microtubule (GO:0047497)2.21421413
142cerebral cortex cell migration (GO:0021795)2.21375852
143neurofilament cytoskeleton organization (GO:0060052)2.21100650
144somite development (GO:0061053)2.20612528
145acrosome assembly (GO:0001675)2.19566523
146cilium morphogenesis (GO:0060271)2.17564422
147detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.17557807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.98757990
2GBX2_23144817_ChIP-Seq_PC3_Human3.86124423
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15858611
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99308767
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95377787
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.92948781
7REST_21632747_ChIP-Seq_MESCs_Mouse2.87226341
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.81530646
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.79309195
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67752864
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.58763626
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55716691
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55716691
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.52320590
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50491840
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.50437720
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41237713
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39186979
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32603316
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.31451979
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.28767263
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.26671967
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.22735838
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20542690
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14953570
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11910685
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11854229
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.10952853
29ZNF274_21170338_ChIP-Seq_K562_Hela2.05652460
30CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05237023
31IGF1R_20145208_ChIP-Seq_DFB_Human2.04777827
32* TAF15_26573619_Chip-Seq_HEK293_Human1.97371941
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87149740
34AR_21572438_ChIP-Seq_LNCaP_Human1.86362345
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83782070
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81105595
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.78860516
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74404981
39FUS_26573619_Chip-Seq_HEK293_Human1.72226186
40DROSHA_22980978_ChIP-Seq_HELA_Human1.69891106
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.69349935
42* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66827234
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.63831206
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63638027
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61939757
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61047745
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60147363
48RNF2_27304074_Chip-Seq_NSC_Mouse1.59540360
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56402070
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54787678
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52491260
52SMAD4_21799915_ChIP-Seq_A2780_Human1.52437940
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52142210
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50880130
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.48495118
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41231735
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39492448
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37493301
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36524370
60BCAT_22108803_ChIP-Seq_LS180_Human1.36181401
61ER_23166858_ChIP-Seq_MCF-7_Human1.36065811
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35356001
63P300_19829295_ChIP-Seq_ESCs_Human1.33206559
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32908714
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31277755
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.30790089
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28354471
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24367703
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.22597226
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21710796
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21418129
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20540623
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20197694
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19878297
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19303638
76AR_19668381_ChIP-Seq_PC3_Human1.19291331
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18030088
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17893428
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16967696
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16084987
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15994213
82EWS_26573619_Chip-Seq_HEK293_Human1.15629596
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15618720
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15319919
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15319919
86AR_25329375_ChIP-Seq_VCAP_Human1.14579097
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14262025
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.14058239
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13923971
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13389902
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12514568
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12132792
93DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11622040
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10669022
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10022126
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.09541666
97STAT3_23295773_ChIP-Seq_U87_Human1.08767833
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08581794
99TCF4_22108803_ChIP-Seq_LS180_Human1.08047621
100TP53_22573176_ChIP-Seq_HFKS_Human1.07844913
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07212729
102EST1_17652178_ChIP-ChIP_JURKAT_Human1.06546485
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.05716447
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05544428
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05509640
106SOX9_26525672_Chip-Seq_HEART_Mouse1.05239304
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04643677
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04190943
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.02949253
110MYC_18940864_ChIP-ChIP_HL60_Human1.02129131
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.01915267
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01378673
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.01179344
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.00680915
115CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00426215
116P53_22387025_ChIP-Seq_ESCs_Mouse1.00238175
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00058606
118PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99328491
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99021575
120NANOG_19829295_ChIP-Seq_ESCs_Human0.98822053
121SOX2_19829295_ChIP-Seq_ESCs_Human0.98822053
122JUN_21703547_ChIP-Seq_K562_Human0.96973693
123OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96463496
124TCF4_23295773_ChIP-Seq_U87_Human0.94458424
125* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93980176
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93074150
127VDR_22108803_ChIP-Seq_LS180_Human0.91071082
128SMAD_19615063_ChIP-ChIP_OVARY_Human0.89216619
129WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88549163
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.88509299
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88477162
132HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87848589
133SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86035044
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85390255
135CBP_20019798_ChIP-Seq_JUKART_Human0.85390255
136EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85124532
137RUNX2_22187159_ChIP-Seq_PCA_Human0.84992570
138TP53_20018659_ChIP-ChIP_R1E_Mouse0.84028746
139POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.83845809
140SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83708644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.36178442
2MP0003880_abnormal_central_pattern4.28039455
3MP0003635_abnormal_synaptic_transmissio3.57053188
4MP0002063_abnormal_learning/memory/cond2.99045566
5MP0005423_abnormal_somatic_nervous2.93047840
6MP0009745_abnormal_behavioral_response2.88005948
7MP0001968_abnormal_touch/_nociception2.63567552
8MP0003122_maternal_imprinting2.48393683
9MP0004270_analgesia2.46174643
10MP0002572_abnormal_emotion/affect_behav2.40298625
11MP0002064_seizures2.36547383
12MP0002822_catalepsy2.19121495
13MP0002735_abnormal_chemical_nociception2.13576626
14MP0009046_muscle_twitch2.08115144
15MP0002909_abnormal_adrenal_gland2.07550957
16MP0001486_abnormal_startle_reflex2.06911496
17MP0002272_abnormal_nervous_system2.04906977
18MP0005646_abnormal_pituitary_gland1.97476455
19MP0002734_abnormal_mechanical_nocicepti1.96272029
20MP0006276_abnormal_autonomic_nervous1.88267238
21MP0005645_abnormal_hypothalamus_physiol1.88043589
22MP0002184_abnormal_innervation1.87837222
23MP0002736_abnormal_nociception_after1.87381226
24MP0000778_abnormal_nervous_system1.86299626
25MP0002557_abnormal_social/conspecific_i1.80138136
26MP0002067_abnormal_sensory_capabilities1.79244594
27MP0008789_abnormal_olfactory_epithelium1.76855804
28MP0003123_paternal_imprinting1.74963739
29MP0003890_abnormal_embryonic-extraembry1.74484819
30MP0002733_abnormal_thermal_nociception1.70244902
31MP0000631_abnormal_neuroendocrine_gland1.67321209
32MP0000013_abnormal_adipose_tissue1.66918739
33MP0001440_abnormal_grooming_behavior1.63677116
34MP0001529_abnormal_vocalization1.61874861
35MP0004811_abnormal_neuron_physiology1.59364782
36MP0000955_abnormal_spinal_cord1.58568911
37MP0001501_abnormal_sleep_pattern1.58554091
38MP0004924_abnormal_behavior1.57727686
39MP0005386_behavior/neurological_phenoty1.57727686
40MP0005187_abnormal_penis_morphology1.56083448
41MP0001970_abnormal_pain_threshold1.52436054
42MP0009780_abnormal_chondrocyte_physiolo1.52159721
43MP0001188_hyperpigmentation1.50984377
44MP0001502_abnormal_circadian_rhythm1.50864097
45MP0003121_genomic_imprinting1.50515130
46MP0004133_heterotaxia1.50158848
47MP0006072_abnormal_retinal_apoptosis1.47433518
48MP0003879_abnormal_hair_cell1.45901264
49MP0008569_lethality_at_weaning1.43199133
50MP0003787_abnormal_imprinting1.42555755
51MP0001984_abnormal_olfaction1.41662621
52MP0002882_abnormal_neuron_morphology1.36099209
53MP0003283_abnormal_digestive_organ1.32257528
54MP0002638_abnormal_pupillary_reflex1.24940654
55MP0004215_abnormal_myocardial_fiber1.24677516
56MP0002938_white_spotting1.23940676
57MP0002152_abnormal_brain_morphology1.19005551
58MP0002066_abnormal_motor_capabilities/c1.18219980
59MP0006292_abnormal_olfactory_placode1.17680836
60MP0002234_abnormal_pharynx_morphology1.16910758
61MP0005551_abnormal_eye_electrophysiolog1.16700285
62MP0003718_maternal_effect1.15646243
63MP0001293_anophthalmia1.07143920
64MP0002653_abnormal_ependyma_morphology1.06348573
65MP0003137_abnormal_impulse_conducting1.04281138
66MP0000049_abnormal_middle_ear1.04212086
67MP0002233_abnormal_nose_morphology1.03740603
68MP0004858_abnormal_nervous_system1.03389195
69MP0000751_myopathy1.03381508
70MP0002751_abnormal_autonomic_nervous1.02637123
71MP0003937_abnormal_limbs/digits/tail_de1.00490282
72MP0004147_increased_porphyrin_level0.97673815
73MP0004085_abnormal_heartbeat0.95543548
74MP0004043_abnormal_pH_regulation0.93984434
75MP0008058_abnormal_DNA_repair0.93517511
76MP0001986_abnormal_taste_sensitivity0.93126766
77MP0008877_abnormal_DNA_methylation0.92255381
78MP0008961_abnormal_basal_metabolism0.91198383
79MP0001299_abnormal_eye_distance/0.90748776
80MP0001905_abnormal_dopamine_level0.90622263
81MP0004145_abnormal_muscle_electrophysio0.90489254
82MP0004233_abnormal_muscle_weight0.90240472
83MP0000569_abnormal_digit_pigmentation0.90118101
84MP0003315_abnormal_perineum_morphology0.90079384
85MP0003329_amyloid_beta_deposits0.89652463
86MP0000026_abnormal_inner_ear0.89620961
87MP0004885_abnormal_endolymph0.89517877
88MP0003861_abnormal_nervous_system0.88055469
89MP0008872_abnormal_physiological_respon0.87922285
90MP0001177_atelectasis0.87567582
91MP0003119_abnormal_digestive_system0.87065190
92MP0005253_abnormal_eye_physiology0.86386372
93MP0002160_abnormal_reproductive_system0.84984512
94MP0010386_abnormal_urinary_bladder0.84825330
95MP0005195_abnormal_posterior_eye0.83354260
96MP0002752_abnormal_somatic_nervous0.81473184
97MP0002069_abnormal_eating/drinking_beha0.81430126
98MP0002089_abnormal_postnatal_growth/wei0.80826056
99MP0001963_abnormal_hearing_physiology0.80251961
100MP0000427_abnormal_hair_cycle0.79237771
101MP0004142_abnormal_muscle_tone0.78517488
102MP0003938_abnormal_ear_development0.77159777
103MP0002229_neurodegeneration0.77155173
104MP0000647_abnormal_sebaceous_gland0.77079633
105MP0003633_abnormal_nervous_system0.76623129
106MP0002102_abnormal_ear_morphology0.76192615
107MP0000566_synostosis0.74230626
108MP0008995_early_reproductive_senescence0.74157455
109MP0003755_abnormal_palate_morphology0.72536920
110MP0002876_abnormal_thyroid_physiology0.72136086
111MP0001664_abnormal_digestion0.71632226
112MP0002210_abnormal_sex_determination0.70671877
113MP0004084_abnormal_cardiac_muscle0.70404561
114MP0004742_abnormal_vestibular_system0.69577383
115MP0003942_abnormal_urinary_system0.68147928
116MP0001485_abnormal_pinna_reflex0.67852906
117MP0005394_taste/olfaction_phenotype0.66521825
118MP0005499_abnormal_olfactory_system0.66521825
119MP0002090_abnormal_vision0.66432394
120MP0003631_nervous_system_phenotype0.65837506
121MP0001943_abnormal_respiration0.64726177
122MP0002837_dystrophic_cardiac_calcinosis0.64533199
123MP0000537_abnormal_urethra_morphology0.62593039
124MP0002082_postnatal_lethality0.62299674
125MP0010770_preweaning_lethality0.62299674

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.93873840
2Myokymia (HP:0002411)4.94459511
3Visual hallucinations (HP:0002367)4.66754120
4Focal seizures (HP:0007359)4.04903103
5Epileptic encephalopathy (HP:0200134)4.00946194
6Abnormality of the labia minora (HP:0012880)3.48623552
7Broad-based gait (HP:0002136)3.31293683
8Medial flaring of the eyebrow (HP:0010747)3.28570720
9Absence seizures (HP:0002121)3.24647719
10Progressive cerebellar ataxia (HP:0002073)3.21009596
11Febrile seizures (HP:0002373)3.11471124
12Dialeptic seizures (HP:0011146)3.08510016
13Atonic seizures (HP:0010819)3.07685350
14Papilledema (HP:0001085)3.01097422
15Pancreatic fibrosis (HP:0100732)2.97286211
16Amyotrophic lateral sclerosis (HP:0007354)2.93655997
17Gonadotropin excess (HP:0000837)2.92305845
18Congenital primary aphakia (HP:0007707)2.89089335
19Depression (HP:0000716)2.84418291
20Poor eye contact (HP:0000817)2.82056192
21Pancreatic cysts (HP:0001737)2.79563181
22Abnormal eating behavior (HP:0100738)2.77472943
23Protruding tongue (HP:0010808)2.76063535
24Genital tract atresia (HP:0001827)2.74659222
25Dysdiadochokinesis (HP:0002075)2.74626868
26Nephrogenic diabetes insipidus (HP:0009806)2.68525550
27Truncal ataxia (HP:0002078)2.67886786
28Vaginal atresia (HP:0000148)2.65073527
29True hermaphroditism (HP:0010459)2.65034320
30Molar tooth sign on MRI (HP:0002419)2.64623834
31Abnormality of midbrain morphology (HP:0002418)2.64623834
32Excessive salivation (HP:0003781)2.63898092
33Drooling (HP:0002307)2.63898092
34Epileptiform EEG discharges (HP:0011182)2.62845100
35Generalized tonic-clonic seizures (HP:0002069)2.62262080
36Nephronophthisis (HP:0000090)2.54521994
37EEG with generalized epileptiform discharges (HP:0011198)2.54473900
38Volvulus (HP:0002580)2.50303080
39Limb dystonia (HP:0002451)2.47432009
40Polyphagia (HP:0002591)2.46477581
41Gaze-evoked nystagmus (HP:0000640)2.44609662
42Anxiety (HP:0000739)2.40013727
43Spinal canal stenosis (HP:0003416)2.38853729
44Annular pancreas (HP:0001734)2.38802851
45Progressive inability to walk (HP:0002505)2.38266064
46Megalencephaly (HP:0001355)2.33678925
47Hypsarrhythmia (HP:0002521)2.32826589
48Hepatoblastoma (HP:0002884)2.29524743
49Hyperventilation (HP:0002883)2.27169237
50Impaired smooth pursuit (HP:0007772)2.25724169
51Neuroendocrine neoplasm (HP:0100634)2.21017399
52Abnormal social behavior (HP:0012433)2.20003704
53Impaired social interactions (HP:0000735)2.20003704
54Ankyloglossia (HP:0010296)2.19744586
55Failure to thrive in infancy (HP:0001531)2.19572983
56Mutism (HP:0002300)2.18972917
57Optic nerve hypoplasia (HP:0000609)2.16623993
58Supernumerary spleens (HP:0009799)2.16114128
59Septo-optic dysplasia (HP:0100842)2.15342751
60Abnormality of the renal medulla (HP:0100957)2.13615982
61Hemiparesis (HP:0001269)2.12704270
62Macroorchidism (HP:0000053)2.12085066
63Pointed chin (HP:0000307)2.11931198
64Stereotypic behavior (HP:0000733)2.11863926
65Agitation (HP:0000713)2.11542229
66Action tremor (HP:0002345)2.10403605
67Genetic anticipation (HP:0003743)2.09814080
68Intestinal atresia (HP:0011100)2.09570848
69Hypothermia (HP:0002045)2.08997582
70Poor coordination (HP:0002370)2.08351766
71Lower limb asymmetry (HP:0100559)2.07011386
72Pheochromocytoma (HP:0002666)2.06893525
73Urinary bladder sphincter dysfunction (HP:0002839)2.05846287
74Pachygyria (HP:0001302)2.04480838
75Renal cortical cysts (HP:0000803)2.04088670
76Abnormality of the renal cortex (HP:0011035)2.03119150
77Cortical dysplasia (HP:0002539)2.02806499
78Acute necrotizing encephalopathy (HP:0006965)2.01460570
79Neoplasm of the peripheral nervous system (HP:0100007)2.00499204
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99311026
81Impaired vibration sensation in the lower limbs (HP:0002166)1.99126766
82Lissencephaly (HP:0001339)1.98844019
83Amblyopia (HP:0000646)1.98173941
84Retinal dysplasia (HP:0007973)1.97405892
85Aplasia/Hypoplasia of the brainstem (HP:0007362)1.97397702
86Hypoplasia of the brainstem (HP:0002365)1.97397702
87Bradykinesia (HP:0002067)1.96107085
88Enlarged penis (HP:0000040)1.95197227
89Postaxial hand polydactyly (HP:0001162)1.94487755
90Ankle clonus (HP:0011448)1.94290410
91Sclerocornea (HP:0000647)1.92979938
92Abnormality of the lower motor neuron (HP:0002366)1.92504051
93Progressive macrocephaly (HP:0004481)1.92160563
94Insomnia (HP:0100785)1.90162939
95Gait imbalance (HP:0002141)1.89662547
96Aplasia/Hypoplasia of the tibia (HP:0005772)1.88840386
97Sacral dimple (HP:0000960)1.88421456
98Anencephaly (HP:0002323)1.87946773
99Poor suck (HP:0002033)1.84907919
100Exotropia (HP:0000577)1.84578273
101Abnormality of ocular smooth pursuit (HP:0000617)1.84083833
102Oligodactyly (hands) (HP:0001180)1.82358978
103Neoplasm of the adrenal cortex (HP:0100641)1.82210737
104Sleep apnea (HP:0010535)1.82170212
105Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.81667403
106Torticollis (HP:0000473)1.81277978
107Specific learning disability (HP:0001328)1.80727283
108Congenital stationary night blindness (HP:0007642)1.80219974
109Spastic tetraplegia (HP:0002510)1.79704001
110Decreased testicular size (HP:0008734)1.79208651
111Postural instability (HP:0002172)1.79148703
112Methylmalonic acidemia (HP:0002912)1.78893758
113Atrophy/Degeneration involving motor neurons (HP:0007373)1.78776424
114Intellectual disability, profound (HP:0002187)1.78575977
115Inability to walk (HP:0002540)1.78032426
116Narrow forehead (HP:0000341)1.77885174
117Unsteady gait (HP:0002317)1.77270658
118Pendular nystagmus (HP:0012043)1.77180517
119Shoulder girdle muscle weakness (HP:0003547)1.76434346
120Obstructive sleep apnea (HP:0002870)1.76334315
121Generalized myoclonic seizures (HP:0002123)1.75799403
122Focal dystonia (HP:0004373)1.75656969
123Renal hypoplasia (HP:0000089)1.75395468
124Hypoventilation (HP:0002791)1.75395176
125Bifid tongue (HP:0010297)1.74331533
126Aplasia/Hypoplasia of the tongue (HP:0010295)1.73838210
127Abolished electroretinogram (ERG) (HP:0000550)1.73268015
128Acute encephalopathy (HP:0006846)1.73072169
129Absent speech (HP:0001344)1.72494018
130Abnormality of the corticospinal tract (HP:0002492)1.72072575
131Abnormal EKG (HP:0003115)1.71719458
132Short tibia (HP:0005736)1.71113130
133Type II lissencephaly (HP:0007260)1.70839962
134Micropenis (HP:0000054)1.70497516
135Broad foot (HP:0001769)1.70180889
136Colon cancer (HP:0003003)1.69197789
137Inappropriate behavior (HP:0000719)1.68884594
138Thyroid-stimulating hormone excess (HP:0002925)1.68350112
139Scrotal hypoplasia (HP:0000046)1.67269646
140Autism (HP:0000717)1.66503099
141Urinary urgency (HP:0000012)1.65186609
142Preaxial hand polydactyly (HP:0001177)1.64853702
143Attention deficit hyperactivity disorder (HP:0007018)1.64773123
144Cystic liver disease (HP:0006706)1.64630296
145Chronic hepatic failure (HP:0100626)1.63310443
146Chorioretinal atrophy (HP:0000533)1.61990413
147Absent septum pellucidum (HP:0001331)1.61914301
148Postaxial foot polydactyly (HP:0001830)1.61912142
149Astrocytoma (HP:0009592)1.61704128
150Abnormality of the astrocytes (HP:0100707)1.61704128
151Glioma (HP:0009733)1.61577083
152Cutaneous finger syndactyly (HP:0010554)1.60694897
153Sporadic (HP:0003745)1.60522604
154Fetal akinesia sequence (HP:0001989)1.60116432
155Neoplasm of the heart (HP:0100544)1.59472548
156Aplasia/Hypoplasia of the sternum (HP:0006714)1.59044842
157Status epilepticus (HP:0002133)1.58607392
158Muscular hypotonia of the trunk (HP:0008936)1.57997630
159Anophthalmia (HP:0000528)1.57989354
160Supranuclear gaze palsy (HP:0000605)1.57208906
161Abnormality of alanine metabolism (HP:0010916)1.55991975
162Hyperalaninemia (HP:0003348)1.55991975
163Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.55991975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.62700595
2MARK14.06829474
3EPHA43.54556587
4FRK2.81166627
5MAP3K92.79224503
6MINK12.67032275
7CASK2.51328696
8CAMKK22.50924809
9KSR12.40484483
10MAP4K22.31615493
11MAP3K42.31413076
12TRIM282.11688918
13NTRK21.97625996
14MAP2K71.95066915
15DAPK11.91883938
16PRPF4B1.88431434
17BMPR1B1.77986654
18DAPK21.77717451
19MAPK131.72723092
20CAMKK11.72171738
21TNIK1.65755104
22LMTK21.61243212
23ERBB31.56621953
24KSR21.53812603
25ZAK1.50868933
26NEK11.50724746
27CDK191.50332391
28MAP3K121.44764437
29PHKG11.42555836
30PHKG21.42555836
31PAK61.42205852
32EPHA31.37439684
33BRSK11.36232405
34CDK51.35256529
35BRD41.35249065
36PLK21.31956807
37CCNB11.28622425
38CDC71.28345689
39ADRBK21.27320918
40MAP2K41.25139232
41CSNK1G11.21838595
42UHMK11.21739332
43DYRK1A1.21326318
44FGFR21.17502284
45OXSR11.17020667
46SCYL21.15026347
47PRKCG1.11515370
48STK391.09260936
49GRK11.05961681
50GRK51.05717132
51CDK180.99406529
52CDK140.98919335
53WNK40.98205535
54SIK20.97761237
55WNK30.97523457
56PRKD30.96872095
57WEE10.95443990
58CSNK1A1L0.95248905
59CDK150.94359834
60VRK10.93384587
61TAOK10.91602509
62NUAK10.89829231
63BRSK20.87120033
64CSNK1G20.86345276
65CDK11A0.84977903
66PKN10.84429883
67MKNK10.83388825
68DYRK30.82206704
69TSSK60.81633445
70PASK0.81487584
71DYRK20.80486931
72CAMK1G0.78669205
73MKNK20.78553695
74FES0.77435455
75SGK4940.77325809
76SGK2230.77325809
77INSRR0.77151524
78CAMK2A0.77012913
79MAP3K20.76293831
80STK38L0.75642637
81CAMK10.74418863
82PDGFRA0.74313966
83PINK10.73808729
84NTRK10.73779107
85SRPK10.73342463
86TTK0.73336048
87RAF10.73147614
88TAOK20.70609924
89MAP3K130.67948161
90LATS20.66356170
91PLK10.63384284
92PLK40.61101602
93STK110.59478770
94BUB10.57681321
95PAK30.57680573
96PNCK0.56853938
97CSNK1G30.55508082
98STK160.52717087
99PLK30.52032516
100CAMK1D0.51456194
101MUSK0.49877838
102CSNK1E0.49387431
103ACVR1B0.49137189
104ADRBK10.48981728
105CDC42BPA0.48856717
106MAPK90.48594143
107CAMK2B0.48411461
108CAMK40.48187189
109SIK30.46164470
110TNK20.46147953
111EPHB20.44583252
112CSNK1A10.44416891
113ATM0.44031578
114RPS6KA30.43648567
115MAPK100.43493627
116CSNK1D0.42575945
117PRKACA0.42413215
118GRK70.42125335
119PRKCZ0.41601563
120CAMK2D0.41430771
121SGK10.40807718
122LIMK10.39803544
123CDK80.39089004
124FGFR10.38636283
125CDK30.38148223
126EIF2AK30.37577970
127PRKCE0.37557693
128MARK20.35761544
129PRKG10.35614015
130BCR0.35548336
131RET0.35140379
132MAP3K60.34185049
133SGK20.33957267
134BRAF0.33002408
135HIPK20.32452105
136TYRO30.32142519
137RPS6KA20.30408577
138EIF2AK10.30144658
139PRKDC0.28312931
140LATS10.27644363
141RPS6KB10.25957618

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.74288833
2Olfactory transduction_Homo sapiens_hsa047402.80466505
3Synaptic vesicle cycle_Homo sapiens_hsa047212.77135565
4Long-term potentiation_Homo sapiens_hsa047202.59487522
5Circadian entrainment_Homo sapiens_hsa047132.58268381
6Amphetamine addiction_Homo sapiens_hsa050312.56240377
7Morphine addiction_Homo sapiens_hsa050322.54414642
8GABAergic synapse_Homo sapiens_hsa047272.52713285
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.49402307
10Glutamatergic synapse_Homo sapiens_hsa047242.42698637
11Dopaminergic synapse_Homo sapiens_hsa047282.26951947
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23706161
13Protein export_Homo sapiens_hsa030602.03566377
14Insulin secretion_Homo sapiens_hsa049111.95396829
15Oxidative phosphorylation_Homo sapiens_hsa001901.92174557
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86681731
17Renin secretion_Homo sapiens_hsa049241.80023193
18Butanoate metabolism_Homo sapiens_hsa006501.79535121
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78024406
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77006250
21Cholinergic synapse_Homo sapiens_hsa047251.75853922
22Salivary secretion_Homo sapiens_hsa049701.73970057
23Cocaine addiction_Homo sapiens_hsa050301.73776563
24Steroid biosynthesis_Homo sapiens_hsa001001.73424804
25Oxytocin signaling pathway_Homo sapiens_hsa049211.68592883
26Taste transduction_Homo sapiens_hsa047421.68303417
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65542973
28Basal transcription factors_Homo sapiens_hsa030221.62334180
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58502574
30Propanoate metabolism_Homo sapiens_hsa006401.57781920
31Serotonergic synapse_Homo sapiens_hsa047261.55245082
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53565375
33Non-homologous end-joining_Homo sapiens_hsa034501.53012823
34Calcium signaling pathway_Homo sapiens_hsa040201.52534115
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45691048
36Long-term depression_Homo sapiens_hsa047301.44676322
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44276465
38Gastric acid secretion_Homo sapiens_hsa049711.42874602
39Gap junction_Homo sapiens_hsa045401.42597593
40Oocyte meiosis_Homo sapiens_hsa041141.40008762
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.34292723
42Homologous recombination_Homo sapiens_hsa034401.28820266
43Cardiac muscle contraction_Homo sapiens_hsa042601.26584555
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22151195
45Fanconi anemia pathway_Homo sapiens_hsa034601.20403260
46Axon guidance_Homo sapiens_hsa043601.19999088
47Type II diabetes mellitus_Homo sapiens_hsa049301.18095919
48GnRH signaling pathway_Homo sapiens_hsa049121.15363338
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15075809
50cAMP signaling pathway_Homo sapiens_hsa040241.12471359
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10876511
52Selenocompound metabolism_Homo sapiens_hsa004501.05819761
53RNA polymerase_Homo sapiens_hsa030201.04440866
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04131576
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04046578
56Estrogen signaling pathway_Homo sapiens_hsa049151.02638925
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01406167
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01390938
59Glioma_Homo sapiens_hsa052140.99182036
60RNA degradation_Homo sapiens_hsa030180.98979409
61Melanogenesis_Homo sapiens_hsa049160.98259630
62Alcoholism_Homo sapiens_hsa050340.97457472
63Linoleic acid metabolism_Homo sapiens_hsa005910.97336512
64N-Glycan biosynthesis_Homo sapiens_hsa005100.95593312
65Ether lipid metabolism_Homo sapiens_hsa005650.92903629
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92642079
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92504604
68Circadian rhythm_Homo sapiens_hsa047100.91688691
69Collecting duct acid secretion_Homo sapiens_hsa049660.90206394
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90161811
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89739611
72Vibrio cholerae infection_Homo sapiens_hsa051100.89288888
73beta-Alanine metabolism_Homo sapiens_hsa004100.88096148
74Peroxisome_Homo sapiens_hsa041460.86827887
75Regulation of autophagy_Homo sapiens_hsa041400.86012293
76Dilated cardiomyopathy_Homo sapiens_hsa054140.85741622
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84216087
78mRNA surveillance pathway_Homo sapiens_hsa030150.83738290
79ErbB signaling pathway_Homo sapiens_hsa040120.83123361
80Colorectal cancer_Homo sapiens_hsa052100.82801272
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82681364
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80321497
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79660026
84Tryptophan metabolism_Homo sapiens_hsa003800.78682776
85Glucagon signaling pathway_Homo sapiens_hsa049220.78472694
86Phototransduction_Homo sapiens_hsa047440.78235465
87Mismatch repair_Homo sapiens_hsa034300.76499642
88Vitamin B6 metabolism_Homo sapiens_hsa007500.75549974
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.75548499
90Basal cell carcinoma_Homo sapiens_hsa052170.74578462
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.73756578
92Wnt signaling pathway_Homo sapiens_hsa043100.72330117
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70940918
94Fatty acid elongation_Homo sapiens_hsa000620.70006163
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.69977189
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69708921
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67777366
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67428172
99Pyruvate metabolism_Homo sapiens_hsa006200.66623172
100DNA replication_Homo sapiens_hsa030300.64930709
101Endometrial cancer_Homo sapiens_hsa052130.64406186
102MAPK signaling pathway_Homo sapiens_hsa040100.64375879
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63453992
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62936518
105Pancreatic secretion_Homo sapiens_hsa049720.62654108
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62520863
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.62365672
108Parkinsons disease_Homo sapiens_hsa050120.61722933
109Nitrogen metabolism_Homo sapiens_hsa009100.61192236
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59280774
111mTOR signaling pathway_Homo sapiens_hsa041500.59269951
112Purine metabolism_Homo sapiens_hsa002300.56480495
113Thyroid hormone synthesis_Homo sapiens_hsa049180.55566814
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55372000
115Choline metabolism in cancer_Homo sapiens_hsa052310.54786967
116Insulin signaling pathway_Homo sapiens_hsa049100.54401556
117Caffeine metabolism_Homo sapiens_hsa002320.54357877
118Spliceosome_Homo sapiens_hsa030400.53822408
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53570589
120Alzheimers disease_Homo sapiens_hsa050100.52681870
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.52350435
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.52207487
123Ovarian steroidogenesis_Homo sapiens_hsa049130.52103385
124Type I diabetes mellitus_Homo sapiens_hsa049400.52030999
125VEGF signaling pathway_Homo sapiens_hsa043700.51408080
126Non-small cell lung cancer_Homo sapiens_hsa052230.50324657
127Arginine and proline metabolism_Homo sapiens_hsa003300.49300568
128Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49203644
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48817359
130Ras signaling pathway_Homo sapiens_hsa040140.47136562
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46405959
132Metabolic pathways_Homo sapiens_hsa011000.46046405
133Hedgehog signaling pathway_Homo sapiens_hsa043400.45827777
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45491144
135Folate biosynthesis_Homo sapiens_hsa007900.45359555
136RNA transport_Homo sapiens_hsa030130.44537877
137Fatty acid metabolism_Homo sapiens_hsa012120.44273220
138Rap1 signaling pathway_Homo sapiens_hsa040150.43486787
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41462794
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40938534
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40771727
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38560989
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38407957
144Thyroid cancer_Homo sapiens_hsa052160.38213417
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37544670
146Huntingtons disease_Homo sapiens_hsa050160.37536006
147Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37318095
148Renal cell carcinoma_Homo sapiens_hsa052110.36496595
149Hippo signaling pathway_Homo sapiens_hsa043900.35632186
150Nucleotide excision repair_Homo sapiens_hsa034200.35238495
151Cell cycle_Homo sapiens_hsa041100.32492434

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