BHLHE22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. A similar protein in mouse is required for the development of the dorsal cochlear nuclei, and is thought to play a role in in the differentiation of neurons involved in sensory input. The mouse protein also functions in retinogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.14072684
2locomotory exploration behavior (GO:0035641)6.08836268
3synaptic vesicle maturation (GO:0016188)5.92206857
4layer formation in cerebral cortex (GO:0021819)5.91222113
5vocalization behavior (GO:0071625)5.75332870
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.73125349
7regulation of short-term neuronal synaptic plasticity (GO:0048172)5.67843123
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.59206586
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.56551212
10protein localization to synapse (GO:0035418)5.50562021
11activation of MAPKKK activity (GO:0000185)5.44858860
12exploration behavior (GO:0035640)5.36304231
13nucleobase catabolic process (GO:0046113)5.21652983
14neuron cell-cell adhesion (GO:0007158)5.21522557
15regulation of glutamate receptor signaling pathway (GO:1900449)5.14240981
16glutamate secretion (GO:0014047)5.09855705
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.03573756
18synaptic vesicle exocytosis (GO:0016079)5.03126445
19positive regulation of synapse maturation (GO:0090129)5.02582466
20dendritic spine morphogenesis (GO:0060997)4.85651140
21regulation of synaptic vesicle exocytosis (GO:2000300)4.70737802
22dendrite morphogenesis (GO:0048813)4.55533034
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.49264514
24neuron recognition (GO:0008038)4.49223176
25postsynaptic membrane organization (GO:0001941)4.46433901
26neurotransmitter-gated ion channel clustering (GO:0072578)4.44199056
27synaptic vesicle docking involved in exocytosis (GO:0016081)4.39035568
28regulation of synapse structural plasticity (GO:0051823)4.35879779
29regulation of long-term neuronal synaptic plasticity (GO:0048169)4.34524632
30axonal fasciculation (GO:0007413)4.26073744
31glutamate receptor signaling pathway (GO:0007215)4.19454297
32regulation of neuronal synaptic plasticity (GO:0048168)4.16294713
33mitochondrion transport along microtubule (GO:0047497)4.13899638
34establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.13899638
35CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.11522492
36regulation of synaptic vesicle transport (GO:1902803)4.09593735
37synaptic transmission, glutamatergic (GO:0035249)4.04347344
38proline transport (GO:0015824)4.01595007
39cerebellar granule cell differentiation (GO:0021707)4.01466301
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.99790397
41establishment of mitochondrion localization (GO:0051654)3.97683273
42regulation of dendritic spine morphogenesis (GO:0061001)3.95877172
43cell migration in hindbrain (GO:0021535)3.93828242
44positive regulation of dendritic spine morphogenesis (GO:0061003)3.93661994
45* central nervous system projection neuron axonogenesis (GO:0021952)3.90900902
46neurotransmitter secretion (GO:0007269)3.88080123
47gamma-aminobutyric acid transport (GO:0015812)3.81854841
48negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.79707562
49regulation of synapse maturation (GO:0090128)3.76127546
50positive regulation of membrane potential (GO:0045838)3.70709294
51neuron-neuron synaptic transmission (GO:0007270)3.69507056
52clathrin coat assembly (GO:0048268)3.69413948
53long-term memory (GO:0007616)3.69100542
54presynaptic membrane assembly (GO:0097105)3.68445248
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59301795
56positive regulation of dendritic spine development (GO:0060999)3.59197494
57axon extension (GO:0048675)3.58956523
58mechanosensory behavior (GO:0007638)3.57549236
59organelle transport along microtubule (GO:0072384)3.55076083
60regulation of dendritic spine development (GO:0060998)3.47337372
61synaptic vesicle endocytosis (GO:0048488)3.44576598
62activation of protein kinase A activity (GO:0034199)3.43270824
63presynaptic membrane organization (GO:0097090)3.40702265
64regulation of synaptic plasticity (GO:0048167)3.39371855
65regulation of postsynaptic membrane potential (GO:0060078)3.39230790
66auditory behavior (GO:0031223)3.38851994
67synapse assembly (GO:0007416)3.38717122
68dendritic spine organization (GO:0097061)3.37941276
69negative regulation of microtubule polymerization (GO:0031115)3.36997158
70neuromuscular process controlling balance (GO:0050885)3.36629979
71transmission of nerve impulse (GO:0019226)3.30970372
72neuron projection extension (GO:1990138)3.28787489
73gamma-aminobutyric acid signaling pathway (GO:0007214)3.28198454
74mitochondrion distribution (GO:0048311)3.27355385
75regulation of cardiac muscle cell contraction (GO:0086004)3.27168478
76axon ensheathment in central nervous system (GO:0032291)3.26858235
77central nervous system myelination (GO:0022010)3.26858235
78nerve growth factor signaling pathway (GO:0038180)3.26112901
79B cell homeostasis (GO:0001782)3.26064331
80cerebral cortex radially oriented cell migration (GO:0021799)3.26033745
81positive regulation of axon extension (GO:0045773)3.24840240
82innervation (GO:0060384)3.23387012
83negative regulation of neurotransmitter secretion (GO:0046929)3.22666209
84neuronal action potential propagation (GO:0019227)3.22084238
85cerebellum development (GO:0021549)3.19398671
86mitochondrial genome maintenance (GO:0000002)3.18856794
87cellular potassium ion homeostasis (GO:0030007)3.16996889
88vesicle transport along microtubule (GO:0047496)3.16372455
89regulation of neurotransmitter secretion (GO:0046928)3.15454634
90negative regulation of dendrite development (GO:2000171)3.13662177
91response to pheromone (GO:0019236)3.11621211
92regulation of vesicle fusion (GO:0031338)3.10245130
93endoderm formation (GO:0001706)3.09971972
94positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09749867
95positive regulation of dendrite morphogenesis (GO:0050775)3.09636094
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09174805
97regulation of dendrite morphogenesis (GO:0048814)3.07448339
98behavioral defense response (GO:0002209)3.07016744
99behavioral fear response (GO:0001662)3.07016744
100regulation of female receptivity (GO:0045924)3.06615254
101synapse organization (GO:0050808)3.06422350
102cardiac ventricle formation (GO:0003211)3.05747918
103regulation of axon extension (GO:0030516)3.05672908
104neurotransmitter transport (GO:0006836)3.04440957
105cerebral cortex neuron differentiation (GO:0021895)3.03960561
106positive regulation of filopodium assembly (GO:0051491)3.03428984
107regulation of synaptic transmission, glutamatergic (GO:0051966)3.02530498
108positive regulation of neurotransmitter secretion (GO:0001956)3.02339716
109establishment of nucleus localization (GO:0040023)3.01739794
110regulation of dendrite development (GO:0050773)3.01707494
111long-term synaptic potentiation (GO:0060291)3.01525537
112* central nervous system neuron axonogenesis (GO:0021955)3.01306410
113intraspecies interaction between organisms (GO:0051703)3.01064717
114social behavior (GO:0035176)3.01064717
115cerebellar Purkinje cell layer development (GO:0021680)2.99870706
116positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.99640876
117positive regulation of dendrite development (GO:1900006)2.98106552
118learning (GO:0007612)2.97705383
119axon cargo transport (GO:0008088)2.96471958
120sodium ion export (GO:0071436)2.96300825
121response to auditory stimulus (GO:0010996)2.95393554
122cell communication by electrical coupling (GO:0010644)2.95132985
123limb bud formation (GO:0060174)2.94941867
124regulation of NFAT protein import into nucleus (GO:0051532)2.90236306
125regulation of sarcomere organization (GO:0060297)2.88629010
126positive regulation of protein homodimerization activity (GO:0090073)2.88320876
127G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.86279439
128positive regulation of cardiac muscle cell differentiation (GO:2000727)2.80609027
129cellular response to nerve growth factor stimulus (GO:1990090)2.79089087
130response to nerve growth factor (GO:1990089)2.79089087
131retinal cone cell development (GO:0046549)2.78751263
132L-amino acid import (GO:0043092)2.77469136
133regulation of synapse organization (GO:0050807)2.77455963
134response to parathyroid hormone (GO:0071107)2.74890273
135cardiac chamber formation (GO:0003207)2.72025895
136negative regulation of dendrite morphogenesis (GO:0050774)2.71989805
137positive regulation of synapse assembly (GO:0051965)2.71307921
138startle response (GO:0001964)2.69310217

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.67930256
2GBX2_23144817_ChIP-Seq_PC3_Human3.36059786
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17584982
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12688346
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97880059
6REST_21632747_ChIP-Seq_MESCs_Mouse2.75185736
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69093803
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69093803
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55891595
10* EZH2_27304074_Chip-Seq_ESCs_Mouse2.55745064
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53298161
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52375149
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51089551
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50131545
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44205371
16DROSHA_22980978_ChIP-Seq_HELA_Human2.42139064
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39780947
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.39267957
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.38200428
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.28504527
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25432729
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.21240108
23AR_21572438_ChIP-Seq_LNCaP_Human2.19847598
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19712327
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.16432052
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14665901
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06190154
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.04280465
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00838670
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84135198
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.82523075
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78100211
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75097690
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72460962
35ZNF274_21170338_ChIP-Seq_K562_Hela1.67527484
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57960110
37MYC_22102868_ChIP-Seq_BL_Human1.57183444
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54986233
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.51356061
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.50903547
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50480370
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.49221625
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.44644647
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44293830
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.42481441
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38520245
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.37797790
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37395421
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.36257561
50* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35713897
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35496057
52* RING1B_27294783_Chip-Seq_NPCs_Mouse1.35432772
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33610151
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33478808
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32843335
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31679445
57SOX9_26525672_Chip-Seq_HEART_Mouse1.28855879
58P300_19829295_ChIP-Seq_ESCs_Human1.28147074
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.27074853
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26437941
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26172813
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26165125
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.25818230
64AR_25329375_ChIP-Seq_VCAP_Human1.25264425
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25155816
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25032092
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.24175198
68AR_19668381_ChIP-Seq_PC3_Human1.22076136
69TAF15_26573619_Chip-Seq_HEK293_Human1.21559453
70KDM2B_26808549_Chip-Seq_K562_Human1.21215156
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20289636
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19068832
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18784042
74LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18634271
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16438523
76IGF1R_20145208_ChIP-Seq_DFB_Human1.16148347
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15549821
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15289644
79STAT3_23295773_ChIP-Seq_U87_Human1.14721820
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.12379278
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12215672
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.09540196
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09512818
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08109791
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07695823
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07663781
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07533291
88FUS_26573619_Chip-Seq_HEK293_Human1.07224837
89* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06490765
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05800173
91* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05640678
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.05440008
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05147209
94CIITA_25753668_ChIP-Seq_RAJI_Human1.04322405
95* RNF2_27304074_Chip-Seq_NSC_Mouse1.02950028
96AHR_22903824_ChIP-Seq_MCF-7_Human1.02668895
97POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02261041
98SMAD3_21741376_ChIP-Seq_ESCs_Human1.00686409
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.00495900
100TCF4_23295773_ChIP-Seq_U87_Human1.00363493
101SMAD4_21741376_ChIP-Seq_HESCs_Human1.00358467
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00293573
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00293573
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99146300
105TP53_16413492_ChIP-PET_HCT116_Human0.97919116
106FLI1_27457419_Chip-Seq_LIVER_Mouse0.95976212
107KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94804775
108JUN_21703547_ChIP-Seq_K562_Human0.94156111
109* NANOG_18555785_Chip-Seq_ESCs_Mouse0.93835017
110ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93703645
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92867527
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92825637
113NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92158514
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91119265
115CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91031293
116RUNX2_22187159_ChIP-Seq_PCA_Human0.91008356
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90790487
118* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90214346
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90080611
120KDM2B_26808549_Chip-Seq_REH_Human0.89666676
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89592752
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88968201
123TP53_18474530_ChIP-ChIP_U2OS_Human0.88924574
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87045814
125TET1_21490601_ChIP-Seq_MESCs_Mouse0.85841532
126SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85240618
127SMAD3_21741376_ChIP-Seq_HESCs_Human0.85202136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.17660006
2MP0004270_analgesia4.39210815
3MP0003880_abnormal_central_pattern4.33153479
4MP0003635_abnormal_synaptic_transmissio4.29762795
5MP0002063_abnormal_learning/memory/cond3.56467958
6MP0009745_abnormal_behavioral_response3.17218392
7MP0005423_abnormal_somatic_nervous3.08319435
8MP0002734_abnormal_mechanical_nocicepti2.90407051
9MP0009780_abnormal_chondrocyte_physiolo2.85842552
10MP0001968_abnormal_touch/_nociception2.83205046
11MP0002064_seizures2.81488868
12* MP0000778_abnormal_nervous_system2.74906135
13MP0002572_abnormal_emotion/affect_behav2.70995404
14MP0009046_muscle_twitch2.60534949
15MP0003329_amyloid_beta_deposits2.59832726
16MP0001486_abnormal_startle_reflex2.32551804
17MP0002184_abnormal_innervation2.22134499
18MP0002733_abnormal_thermal_nociception2.20902952
19MP0002736_abnormal_nociception_after2.15287707
20MP0002272_abnormal_nervous_system2.10191794
21MP0004811_abnormal_neuron_physiology2.09890647
22* MP0001440_abnormal_grooming_behavior2.08827523
23MP0004885_abnormal_endolymph2.01711743
24MP0004858_abnormal_nervous_system1.97634865
25MP0001970_abnormal_pain_threshold1.90040655
26MP0002557_abnormal_social/conspecific_i1.86856660
27* MP0002735_abnormal_chemical_nociception1.83954683
28* MP0000955_abnormal_spinal_cord1.80886220
29* MP0002067_abnormal_sensory_capabilities1.80805052
30MP0008569_lethality_at_weaning1.74431957
31MP0001501_abnormal_sleep_pattern1.70881441
32MP0002909_abnormal_adrenal_gland1.65040940
33MP0003890_abnormal_embryonic-extraembry1.63494443
34* MP0002882_abnormal_neuron_morphology1.60281951
35* MP0004924_abnormal_behavior1.58008475
36* MP0005386_behavior/neurological_phenoty1.58008475
37MP0008789_abnormal_olfactory_epithelium1.56383970
38MP0003879_abnormal_hair_cell1.54225778
39MP0000569_abnormal_digit_pigmentation1.52058448
40* MP0002066_abnormal_motor_capabilities/c1.47871672
41MP0005671_abnormal_response_to1.41493148
42* MP0002152_abnormal_brain_morphology1.40781696
43MP0008057_abnormal_DNA_replication1.37871671
44MP0006276_abnormal_autonomic_nervous1.37219543
45MP0000685_abnormal_immune_system1.35886185
46MP0001346_abnormal_lacrimal_gland1.35878023
47MP0009053_abnormal_anal_canal1.32575865
48MP0005187_abnormal_penis_morphology1.30251031
49MP0001348_abnormal_lacrimal_gland1.28339012
50MP0000604_amyloidosis1.27476865
51MP0000516_abnormal_urinary_system1.26358892
52MP0005367_renal/urinary_system_phenotyp1.26358892
53MP0008872_abnormal_physiological_respon1.19212787
54MP0001984_abnormal_olfaction1.16473718
55MP0002138_abnormal_hepatobiliary_system1.10635355
56MP0003787_abnormal_imprinting1.08492434
57MP0008877_abnormal_DNA_methylation1.08218339
58MP0001502_abnormal_circadian_rhythm1.05768097
59* MP0003633_abnormal_nervous_system1.04108294
60* MP0003631_nervous_system_phenotype1.03708228
61MP0003632_abnormal_nervous_system1.03113883
62MP0003634_abnormal_glial_cell1.02740139
63MP0001800_abnormal_humoral_immune1.02588240
64MP0005645_abnormal_hypothalamus_physiol1.02362385
65MP0003121_genomic_imprinting1.01691908
66MP0003861_abnormal_nervous_system1.00981310
67MP0002166_altered_tumor_susceptibility1.00118708
68MP0004742_abnormal_vestibular_system1.00084452
69MP0001905_abnormal_dopamine_level0.97430690
70MP0001188_hyperpigmentation0.96983225
71MP0005387_immune_system_phenotype0.96875856
72MP0001790_abnormal_immune_system0.96875856
73MP0005220_abnormal_exocrine_pancreas0.95905517
74MP0000631_abnormal_neuroendocrine_gland0.95555224
75MP0002163_abnormal_gland_morphology0.90517809
76MP0002229_neurodegeneration0.90349178
77MP0002069_abnormal_eating/drinking_beha0.89659867
78MP0003303_peritoneal_inflammation0.89483926
79MP0004145_abnormal_muscle_electrophysio0.89179102
80MP0002928_abnormal_bile_duct0.87939209
81MP0004142_abnormal_muscle_tone0.87300695
82MP0003183_abnormal_peptide_metabolism0.85523476
83* MP0002752_abnormal_somatic_nervous0.83522295
84MP0004130_abnormal_muscle_cell0.82929544
85MP0001177_atelectasis0.80772703
86MP0001963_abnormal_hearing_physiology0.80444197
87MP0002837_dystrophic_cardiac_calcinosis0.79330261
88MP0005499_abnormal_olfactory_system0.78958989
89MP0005394_taste/olfaction_phenotype0.78958989
90MP0003119_abnormal_digestive_system0.78716606
91MP0002234_abnormal_pharynx_morphology0.78086468
92MP0004233_abnormal_muscle_weight0.77954072
93MP0000920_abnormal_myelination0.77594476
94MP0004510_myositis0.77515298
95MP0005551_abnormal_eye_electrophysiolog0.77445098
96MP0000751_myopathy0.76424960
97MP0004484_altered_response_of0.76375925
98MP0004085_abnormal_heartbeat0.76323171
99MP0003137_abnormal_impulse_conducting0.74356984
100MP0000537_abnormal_urethra_morphology0.73163403
101MP0001485_abnormal_pinna_reflex0.72624889
102MP0000534_abnormal_ureter_morphology0.72026639
103MP0010234_abnormal_vibrissa_follicle0.71133797
104MP0000566_synostosis0.69673713
105MP0005623_abnormal_meninges_morphology0.69467403
106MP0002081_perinatal_lethality0.68726122
107MP0004215_abnormal_myocardial_fiber0.68154989
108MP0002102_abnormal_ear_morphology0.67961874
109MP0008874_decreased_physiological_sensi0.67324193
110MP0003283_abnormal_digestive_organ0.67317262
111MP0001299_abnormal_eye_distance/0.66285374
112MP0001943_abnormal_respiration0.64460205
113MP0002090_abnormal_vision0.64177146
114MP0001835_abnormal_antigen_presentation0.64009290
115MP0009379_abnormal_foot_pigmentation0.63595679
116MP0002822_catalepsy0.62889061
117MP0003938_abnormal_ear_development0.62860001
118MP0002089_abnormal_postnatal_growth/wei0.62253102
119MP0002009_preneoplasia0.61144246
120MP0010769_abnormal_survival0.60613925
121MP0005646_abnormal_pituitary_gland0.60341861
122MP0001529_abnormal_vocalization0.60205058
123MP0002082_postnatal_lethality0.58323796
124MP0010770_preweaning_lethality0.58323796
125MP0000026_abnormal_inner_ear0.58186350
126MP0003172_abnormal_lysosome_physiology0.58129339
127MP0003075_altered_response_to0.58019485
128MP0005535_abnormal_body_temperature0.57813103
129MP0006292_abnormal_olfactory_placode0.57730351
130MP0003868_abnormal_feces_composition0.57628630
131MP0003690_abnormal_glial_cell0.56851879
132MP0010768_mortality/aging0.56316325

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.54217191
2Focal motor seizures (HP:0011153)5.44417265
3Visual hallucinations (HP:0002367)5.39270625
4Mutism (HP:0002300)4.87870804
5Amyotrophic lateral sclerosis (HP:0007354)4.66138730
6Focal seizures (HP:0007359)4.65180442
7Epileptic encephalopathy (HP:0200134)4.57796895
8Supranuclear gaze palsy (HP:0000605)4.35514871
9Gastrointestinal stroma tumor (HP:0100723)4.26692293
10Cerebral inclusion bodies (HP:0100314)4.19780627
11Neurofibrillary tangles (HP:0002185)4.02868645
12Broad-based gait (HP:0002136)3.95405926
13Papilledema (HP:0001085)3.86772670
14Progressive cerebellar ataxia (HP:0002073)3.78364909
15Abnormality of the corticospinal tract (HP:0002492)3.72596052
16Drooling (HP:0002307)3.67736266
17Excessive salivation (HP:0003781)3.67736266
18Thickened helices (HP:0000391)3.57515661
19Hyperventilation (HP:0002883)3.57399700
20Poor eye contact (HP:0000817)3.57101371
21Conical tooth (HP:0000698)3.48788748
22Short chin (HP:0000331)3.45217317
23Akinesia (HP:0002304)3.43687845
24Action tremor (HP:0002345)3.41057291
25Absence seizures (HP:0002121)3.33697750
26Inappropriate behavior (HP:0000719)3.33532874
27Obstructive sleep apnea (HP:0002870)3.29676173
28Abnormality of the lower motor neuron (HP:0002366)3.28449991
29Atonic seizures (HP:0010819)3.26599197
30Abnormality of binocular vision (HP:0011514)3.26177552
31Diplopia (HP:0000651)3.26177552
32Termporal pattern (HP:0011008)3.24121783
33Insidious onset (HP:0003587)3.24121783
34Ankle clonus (HP:0011448)3.21649422
35Abnormal social behavior (HP:0012433)3.09126011
36Impaired social interactions (HP:0000735)3.09126011
37Agammaglobulinemia (HP:0004432)3.05419589
38Generalized tonic-clonic seizures (HP:0002069)3.04157798
39Recurrent sinusitis (HP:0011108)3.03355952
40Dialeptic seizures (HP:0011146)3.01994616
41Megalencephaly (HP:0001355)2.99432076
42Febrile seizures (HP:0002373)2.94758980
43Apathy (HP:0000741)2.93672560
44Hyperlipoproteinemia (HP:0010980)2.93157782
45Genetic anticipation (HP:0003743)2.90913149
46Limb dystonia (HP:0002451)2.90485409
47Urinary bladder sphincter dysfunction (HP:0002839)2.88483577
48Urinary urgency (HP:0000012)2.77148229
49Hemiparesis (HP:0001269)2.77003704
50IgA deficiency (HP:0002720)2.76687215
51Impaired vibration sensation in the lower limbs (HP:0002166)2.75645462
52Amblyopia (HP:0000646)2.71998642
53Epileptiform EEG discharges (HP:0011182)2.70435939
54Depression (HP:0000716)2.68717826
55EEG with generalized epileptiform discharges (HP:0011198)2.67571864
56Polyphagia (HP:0002591)2.64342965
57Progressive inability to walk (HP:0002505)2.63531512
58Diminished motivation (HP:0000745)2.63266749
59Athetosis (HP:0002305)2.62760607
60Abnormal eating behavior (HP:0100738)2.62222098
61Stereotypic behavior (HP:0000733)2.61940116
62Hypsarrhythmia (HP:0002521)2.61420781
63Spastic gait (HP:0002064)2.57214231
64Morphological abnormality of the pyramidal tract (HP:0002062)2.55938823
65Dysdiadochokinesis (HP:0002075)2.54674466
66Dysmetria (HP:0001310)2.54091821
67Inability to walk (HP:0002540)2.53515894
68Gaze-evoked nystagmus (HP:0000640)2.50916973
69Disinhibition (HP:0000734)2.49320635
70Recurrent bronchitis (HP:0002837)2.48566857
71Intention tremor (HP:0002080)2.48484776
72Absent speech (HP:0001344)2.46802674
73Pachygyria (HP:0001302)2.46655700
74Torticollis (HP:0000473)2.46596621
75Truncal ataxia (HP:0002078)2.46266310
76Fetal akinesia sequence (HP:0001989)2.42360703
77Hepatoblastoma (HP:0002884)2.39856012
78Agitation (HP:0000713)2.38733337
79Tented upper lip vermilion (HP:0010804)2.38113014
80Anxiety (HP:0000739)2.37556125
81Abnormality of salivation (HP:0100755)2.34678794
82Mild short stature (HP:0003502)2.32123940
83Postural instability (HP:0002172)2.30968809
84Abnormality of incisor morphology (HP:0011063)2.29443596
85Lymphopenia (HP:0001888)2.28437195
86Abnormality of cells of the lymphoid lineage (HP:0012140)2.23453007
87Lower limb muscle weakness (HP:0007340)2.21937897
88Bradykinesia (HP:0002067)2.21754086
89Focal dystonia (HP:0004373)2.20566250
90Lissencephaly (HP:0001339)2.20539923
91Generalized myoclonic seizures (HP:0002123)2.20308940
92Aqueductal stenosis (HP:0002410)2.19804585
93Impaired smooth pursuit (HP:0007772)2.18136876
94Shawl scrotum (HP:0000049)2.17696694
95Aplasia/Hypoplasia of the brainstem (HP:0007362)2.15501275
96Hypoplasia of the brainstem (HP:0002365)2.15501275
97High anterior hairline (HP:0009890)2.13270109
98Atrophy/Degeneration involving motor neurons (HP:0007373)2.12677531
99Insomnia (HP:0100785)2.10243348
100Long nose (HP:0003189)2.07980137
101Intellectual disability, profound (HP:0002187)2.04884059
102Emphysema (HP:0002097)2.04069112
103Sleep apnea (HP:0010535)2.00266517
104Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.99293111
105Degeneration of the lateral corticospinal tracts (HP:0002314)1.99293111
106Cellulitis (HP:0100658)1.99066686
107Craniofacial dystonia (HP:0012179)1.98976919
108Abnormality of ocular smooth pursuit (HP:0000617)1.98713878
109Sporadic (HP:0003745)1.96751173
110Scanning speech (HP:0002168)1.95077640
111Deep palmar crease (HP:0006191)1.94731766
112Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.93620286
113Lower limb amyotrophy (HP:0007210)1.89648456
114Volvulus (HP:0002580)1.88095317
115Sacral dimple (HP:0000960)1.87264875
116Palpebral edema (HP:0100540)1.87179449
117Neuronal loss in central nervous system (HP:0002529)1.85622372
118Xerostomia (HP:0000217)1.84919392
119Sparse scalp hair (HP:0002209)1.84576173
120Autism (HP:0000717)1.84237456
121Gait imbalance (HP:0002141)1.83564610
122Intellectual disability, severe (HP:0010864)1.82997814
123Neoplasm of the adrenal cortex (HP:0100641)1.81655921
124Meningitis (HP:0001287)1.81419883
125Rapidly progressive (HP:0003678)1.80871491
126Gastroesophageal reflux (HP:0002020)1.79932376
127Esotropia (HP:0000565)1.79499004
128Lower limb asymmetry (HP:0100559)1.77945977
129Hemiplegia (HP:0002301)1.77874393
130Protruding tongue (HP:0010808)1.77268502
131Status epilepticus (HP:0002133)1.76206221
132Heterotopia (HP:0002282)1.68859184
133Cerebral hypomyelination (HP:0006808)1.66343271
134Postural tremor (HP:0002174)1.66210124
135Abnormal pancreas size (HP:0012094)1.65678083
136Open mouth (HP:0000194)1.65035967
137Vasculitis (HP:0002633)1.62974512
138Recurrent pneumonia (HP:0006532)1.62955873
139Fair hair (HP:0002286)1.62792076
140Memory impairment (HP:0002354)1.60690945
141B lymphocytopenia (HP:0010976)1.59679170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK17.39233542
2MAP3K93.89333236
3NTRK33.26363949
4EPHA42.87135726
5MINK12.83248764
6MAP3K42.63893020
7DAPK22.22651786
8PHKG12.19100058
9PHKG22.19100058
10NTRK22.16853850
11MAP2K72.15332911
12PAK62.12962152
13LATS22.05855561
14DYRK21.90406162
15MAPK131.79997247
16KSR11.77799937
17CASK1.74586181
18KSR21.73294134
19MAP3K101.69297184
20SIK21.66939859
21PLK21.66706359
22MAP2K41.62976539
23CAMKK11.62280402
24CDK51.48392135
25PNCK1.40557981
26ACVR1B1.40516904
27NTRK11.36721408
28ERBB31.35352678
29PRKD31.29644718
30TLK11.25972837
31DAPK11.20515332
32CSNK1G21.19442583
33EPHA31.18495678
34SGK21.17693318
35BMPR1B1.14042403
36PRPF4B1.13557908
37GRK51.13197189
38PINK11.11921384
39PRKCG1.09402775
40TNIK1.06067817
41MAP3K21.05378503
42MAP3K121.04070718
43EIF2AK31.02857805
44MARK21.01421745
45PKN10.99707283
46DYRK1A0.98943220
47CDK140.97912395
48TYRO30.97481699
49CDK150.95278842
50CDK180.94480611
51AKT30.94306644
52PAK30.92889305
53MAP3K60.91494868
54RET0.91013080
55STK110.89987270
56CDK190.88762683
57UHMK10.88695720
58MAPK120.88455042
59SCYL20.83744702
60TAOK10.83741072
61CDK11A0.83139070
62CAMK2A0.81941048
63BRAF0.79940184
64CCNB10.77847756
65PRKCZ0.77394985
66NEK90.76363450
67RIPK40.74848436
68MAP4K10.74133930
69MAPK70.73113567
70CAMKK20.72510455
71MAP3K140.71134887
72MAP2K60.70311061
73ALK0.67137300
74FES0.66543124
75STK380.66120926
76PRKCQ0.66048947
77CDK30.64762932
78EEF2K0.64049846
79CSNK1G30.62364807
80EPHB20.61657537
81IRAK20.61084308
82SGK30.60888501
83CAMK10.60706581
84CAMK2B0.59107069
85FGFR30.57989280
86CSNK1A1L0.57432610
87RAF10.57163049
88FYN0.57140367
89IRAK40.55655230
90TGFBR10.54205621
91BCR0.54093108
92FGR0.54038848
93PTK2B0.53659917
94LIMK10.53495047
95MAPK40.53223561
96SGK10.53015606
97CSF1R0.52383121
98PASK0.51370460
99SYK0.50885245
100RPS6KA20.49041720
101PRKCH0.48464837
102YES10.47264049
103KIT0.45909416
104PRKCE0.45616853
105FRK0.44988778
106CAMK40.44435748
107PDK10.44403071
108MELK0.44188585
109FGFR20.43921460
110RIPK10.42124187
111ICK0.41608627
112OXSR10.40361420
113VRK10.39968507
114PDPK10.37950451
115ROCK20.37937394
116RPS6KA30.36515088
117SGK2230.36329339
118SGK4940.36329339
119CAMK1G0.35908520
120TSSK60.33868899
121GSK3B0.33299495
122CSNK1D0.33158556
123PRKCD0.32102191
124MAPK90.31488514
125ABL20.30436961
126DMPK0.30435109
127DYRK1B0.30050779
128BRD40.29754008
129PRKCI0.29526496
130CSNK1G10.29160148
131LMTK20.28297147
132IKBKE0.27822201
133PDK40.27726586
134PDK30.27726586
135MAPK100.26708975
136ARAF0.26473052
137FER0.26275122
138DAPK30.25262329
139PRKG10.25081697
140MAP3K130.24401460

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.36918419
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.03681104
3Synaptic vesicle cycle_Homo sapiens_hsa047212.76275192
4Long-term potentiation_Homo sapiens_hsa047202.76084182
5Circadian entrainment_Homo sapiens_hsa047132.65941169
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58416056
7Glutamatergic synapse_Homo sapiens_hsa047242.55383580
8Allograft rejection_Homo sapiens_hsa053302.46796170
9GABAergic synapse_Homo sapiens_hsa047272.45995907
10Olfactory transduction_Homo sapiens_hsa047402.29672386
11Morphine addiction_Homo sapiens_hsa050322.27842994
12Dopaminergic synapse_Homo sapiens_hsa047282.20317658
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18652792
14Amphetamine addiction_Homo sapiens_hsa050312.16672091
15Asthma_Homo sapiens_hsa053102.14605017
16Autoimmune thyroid disease_Homo sapiens_hsa053202.11373481
17B cell receptor signaling pathway_Homo sapiens_hsa046622.06605565
18Salivary secretion_Homo sapiens_hsa049702.00746077
19Cholinergic synapse_Homo sapiens_hsa047251.96051995
20Type I diabetes mellitus_Homo sapiens_hsa049401.93602559
21Axon guidance_Homo sapiens_hsa043601.90447688
22Graft-versus-host disease_Homo sapiens_hsa053321.87360720
23Long-term depression_Homo sapiens_hsa047301.83942614
24Gastric acid secretion_Homo sapiens_hsa049711.78154259
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77926657
26Systemic lupus erythematosus_Homo sapiens_hsa053221.70157290
27Renin secretion_Homo sapiens_hsa049241.70095447
28Oxytocin signaling pathway_Homo sapiens_hsa049211.68918895
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67984141
30Insulin secretion_Homo sapiens_hsa049111.66654500
31Primary immunodeficiency_Homo sapiens_hsa053401.59431000
32Serotonergic synapse_Homo sapiens_hsa047261.56285009
33Gap junction_Homo sapiens_hsa045401.52877100
34GnRH signaling pathway_Homo sapiens_hsa049121.50098837
35Taste transduction_Homo sapiens_hsa047421.49083380
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46162290
37Glioma_Homo sapiens_hsa052141.42238387
38Estrogen signaling pathway_Homo sapiens_hsa049151.40496588
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35265987
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33604495
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33070055
42Viral myocarditis_Homo sapiens_hsa054161.31985671
43ErbB signaling pathway_Homo sapiens_hsa040121.30162790
44Calcium signaling pathway_Homo sapiens_hsa040201.30063881
45Cocaine addiction_Homo sapiens_hsa050301.27567401
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26399821
47Type II diabetes mellitus_Homo sapiens_hsa049301.25850498
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22757370
49Melanogenesis_Homo sapiens_hsa049161.16448338
50cAMP signaling pathway_Homo sapiens_hsa040241.15961141
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07044665
52Oocyte meiosis_Homo sapiens_hsa041141.06605870
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03812437
54Endometrial cancer_Homo sapiens_hsa052130.98404851
55VEGF signaling pathway_Homo sapiens_hsa043700.96250727
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94148060
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94135094
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93289598
59Renal cell carcinoma_Homo sapiens_hsa052110.89660424
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.89338408
61Dorso-ventral axis formation_Homo sapiens_hsa043200.89254806
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88504429
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.86924416
64Choline metabolism in cancer_Homo sapiens_hsa052310.86781877
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86247321
66Influenza A_Homo sapiens_hsa051640.85225376
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.85020506
68Colorectal cancer_Homo sapiens_hsa052100.84449266
69Collecting duct acid secretion_Homo sapiens_hsa049660.82455372
70Phototransduction_Homo sapiens_hsa047440.80674894
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79288792
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.75577073
73mTOR signaling pathway_Homo sapiens_hsa041500.74803329
74Antigen processing and presentation_Homo sapiens_hsa046120.74749785
75MAPK signaling pathway_Homo sapiens_hsa040100.74014313
76Leishmaniasis_Homo sapiens_hsa051400.73133359
77Epstein-Barr virus infection_Homo sapiens_hsa051690.72335957
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71785550
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71715352
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71415197
81Ras signaling pathway_Homo sapiens_hsa040140.71293414
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68156274
83Cardiac muscle contraction_Homo sapiens_hsa042600.68007699
84Thyroid hormone synthesis_Homo sapiens_hsa049180.64219707
85Dilated cardiomyopathy_Homo sapiens_hsa054140.63536203
86TNF signaling pathway_Homo sapiens_hsa046680.62880498
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62631371
88Wnt signaling pathway_Homo sapiens_hsa043100.62470849
89Pancreatic secretion_Homo sapiens_hsa049720.61973067
90Apoptosis_Homo sapiens_hsa042100.61445458
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60508084
92Herpes simplex infection_Homo sapiens_hsa051680.60051583
93Rap1 signaling pathway_Homo sapiens_hsa040150.59943806
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59809244
95Vibrio cholerae infection_Homo sapiens_hsa051100.59411614
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59103391
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57349991
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57248418
99Measles_Homo sapiens_hsa051620.56956953
100Endocytosis_Homo sapiens_hsa041440.56672758
101Non-small cell lung cancer_Homo sapiens_hsa052230.56508602
102Glucagon signaling pathway_Homo sapiens_hsa049220.56375519
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56363964
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.56341400
105Alcoholism_Homo sapiens_hsa050340.56178305
106Toxoplasmosis_Homo sapiens_hsa051450.55675137
107Hepatitis B_Homo sapiens_hsa051610.55633025
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55556390
109Insulin signaling pathway_Homo sapiens_hsa049100.55457245
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54402648
111Tuberculosis_Homo sapiens_hsa051520.51983627
112Pancreatic cancer_Homo sapiens_hsa052120.50992635
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50830054
114Prion diseases_Homo sapiens_hsa050200.50509082
115T cell receptor signaling pathway_Homo sapiens_hsa046600.49465513
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45198202
117Bile secretion_Homo sapiens_hsa049760.42539336
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.40422980
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38667319
120Hippo signaling pathway_Homo sapiens_hsa043900.38096781
121Chemokine signaling pathway_Homo sapiens_hsa040620.37638353
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36405319
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35748367
124Tight junction_Homo sapiens_hsa045300.35242280
125Prolactin signaling pathway_Homo sapiens_hsa049170.34214269
126AMPK signaling pathway_Homo sapiens_hsa041520.33001849
127Butanoate metabolism_Homo sapiens_hsa006500.32451204
128Platelet activation_Homo sapiens_hsa046110.32442445
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30787802

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