BHLHE40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of activation of Janus kinase activity (GO:0010533)4.49814682
2surfactant homeostasis (GO:0043129)4.07254982
3regulation of memory T cell differentiation (GO:0043380)3.98571124
4tolerance induction (GO:0002507)3.89548776
5regulation of interleukin-12 biosynthetic process (GO:0045075)3.82449940
6response to muramyl dipeptide (GO:0032495)3.66907751
7CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.58428266
8T-helper cell differentiation (GO:0042093)3.58428266
9germinal center formation (GO:0002467)3.51142349
10growth hormone receptor signaling pathway (GO:0060396)3.44739374
11antigen processing and presentation of endogenous antigen (GO:0019883)3.41593837
12negative regulation of erythrocyte differentiation (GO:0045647)3.36439191
13negative thymic T cell selection (GO:0045060)3.31530770
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30940891
15positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.26108665
16interferon-gamma production (GO:0032609)3.24158962
17negative T cell selection (GO:0043383)3.21398261
18endothelial cell chemotaxis (GO:0035767)3.19838373
19regulation of cholesterol homeostasis (GO:2000188)3.19491534
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.19279281
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.19279281
22alpha-beta T cell differentiation involved in immune response (GO:0002293)3.18228104
23alpha-beta T cell activation involved in immune response (GO:0002287)3.18228104
24T cell differentiation involved in immune response (GO:0002292)3.18228104
25positive regulation of p38MAPK cascade (GO:1900745)3.17629925
26positive regulation of T-helper cell differentiation (GO:0045624)3.17139959
27NIK/NF-kappaB signaling (GO:0038061)3.12779475
28positive regulation of natural killer cell differentiation (GO:0032825)3.09911186
29myeloid dendritic cell differentiation (GO:0043011)3.08004035
30JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.07347339
31negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.06918250
32regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.06253970
33CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.05762456
34positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.05080365
35regulation of vitamin D biosynthetic process (GO:0060556)3.04469312
36chemical homeostasis within a tissue (GO:0048875)3.02017871
37activation of MAPKKK activity (GO:0000185)2.99649679
38skin morphogenesis (GO:0043589)2.97478325
39positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.96100504
40positive regulation of heat generation (GO:0031652)2.92733161
41positive regulation of interleukin-12 production (GO:0032735)2.92636134
42desmosome organization (GO:0002934)2.92411241
43cellular response to growth hormone stimulus (GO:0071378)2.90990566
44response to interleukin-15 (GO:0070672)2.90613884
45membrane raft organization (GO:0031579)2.87500630
46embryonic process involved in female pregnancy (GO:0060136)2.86243425
47positive regulation of extracellular matrix organization (GO:1903055)2.86018745
48positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.83862191
49regulation of integrin activation (GO:0033623)2.83344528
50negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.83250821
51negative regulation of cell killing (GO:0031342)2.83250821
52regulation of fever generation (GO:0031620)2.79846095
53regulation of histone H3-K27 methylation (GO:0061085)2.79400035
54negative regulation of lipid storage (GO:0010888)2.77892405
55myeloid dendritic cell activation (GO:0001773)2.75767949
56response to laminar fluid shear stress (GO:0034616)2.75043130
57lipopolysaccharide-mediated signaling pathway (GO:0031663)2.74485957
58regulation of chronic inflammatory response (GO:0002676)2.73631372
59positive regulation of humoral immune response (GO:0002922)2.73579788
60cellular response to interleukin-15 (GO:0071350)2.73085590
61response to peptidoglycan (GO:0032494)2.72988964
62very-low-density lipoprotein particle assembly (GO:0034379)2.72460475
63regulation of T-helper cell differentiation (GO:0045622)2.72425274
64positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.71031744
65negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.70861907
66positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.70154921
67negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.69246767
68regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.68754052
69thymic T cell selection (GO:0045061)2.67673544
70regulation of T-helper 2 cell differentiation (GO:0045628)2.67646331
71positive regulation of activated T cell proliferation (GO:0042104)2.67416340
72positive regulation of gamma-delta T cell activation (GO:0046645)2.66354308
73regulation of hypersensitivity (GO:0002883)2.65709284
74positive regulation of interleukin-17 production (GO:0032740)2.65317481
75regulation of T cell tolerance induction (GO:0002664)2.64632356
76positive regulation of T-helper 1 type immune response (GO:0002827)2.63961031
77tyrosine phosphorylation of STAT protein (GO:0007260)2.63733953
78T cell activation involved in immune response (GO:0002286)2.63207940
79regulation of water loss via skin (GO:0033561)2.63127710
80positive regulation of type 2 immune response (GO:0002830)2.60882957
81COPI coating of Golgi vesicle (GO:0048205)2.60441641
82Golgi transport vesicle coating (GO:0048200)2.60441641
83positive regulation of macrophage differentiation (GO:0045651)2.58448478
84regulation of gamma-delta T cell differentiation (GO:0045586)2.58068746
85granulocyte activation (GO:0036230)2.57670474
86response to type I interferon (GO:0034340)2.56636475
87negative regulation of interleukin-2 production (GO:0032703)2.56479184
88monocyte chemotaxis (GO:0002548)2.55420308
89protein localization to endosome (GO:0036010)2.54999586
90positive regulation of interleukin-2 production (GO:0032743)2.54504368
91neutrophil activation involved in immune response (GO:0002283)2.54140321
92regulation of interleukin-12 production (GO:0032655)2.54012226
93positive regulation of defense response to virus by host (GO:0002230)2.53280762
94regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.53277654
95regulation of gamma-delta T cell activation (GO:0046643)2.53096347
96regulation of T-helper 1 type immune response (GO:0002825)2.52997360
97cellular response to type I interferon (GO:0071357)2.52491412
98type I interferon signaling pathway (GO:0060337)2.52491412
99regulation of vitamin metabolic process (GO:0030656)2.52370215
100positive regulation of osteoclast differentiation (GO:0045672)2.52176216
101detection of bacterium (GO:0016045)2.51997029
102keratinization (GO:0031424)2.50353758
103positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.48952844
104pinocytosis (GO:0006907)2.48536837
105positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.48434534
106neutrophil activation (GO:0042119)2.48197610
107T-helper 1 type immune response (GO:0042088)2.47560158
108T cell selection (GO:0045058)2.47501042
109regulation of podosome assembly (GO:0071801)2.46876082
110detection of other organism (GO:0098543)2.46213568
111positive regulation of T cell mediated cytotoxicity (GO:0001916)2.46160981
112regulation of p38MAPK cascade (GO:1900744)2.45799249
113positive regulation of alpha-beta T cell proliferation (GO:0046641)2.44494554
114positive regulation of isotype switching (GO:0045830)2.44479762
115response to protozoan (GO:0001562)2.44085222
116establishment of skin barrier (GO:0061436)2.42500955
117positive regulation of B cell mediated immunity (GO:0002714)2.42077407
118positive regulation of immunoglobulin mediated immune response (GO:0002891)2.42077407
119regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.40309613
120regulation of T-helper 1 cell differentiation (GO:0045625)2.40072992
121regulation of dendritic cell antigen processing and presentation (GO:0002604)2.39736039
122regulation of membrane protein ectodomain proteolysis (GO:0051043)2.39374132
123regulation of heat generation (GO:0031650)2.39059372
124negative regulation of cytokine production involved in immune response (GO:0002719)2.38687124
125regulation of alpha-beta T cell proliferation (GO:0046640)2.37556716
126tumor necrosis factor-mediated signaling pathway (GO:0033209)2.37521594
127interferon-gamma-mediated signaling pathway (GO:0060333)2.37175707
128positive regulation of keratinocyte differentiation (GO:0045618)2.37114740
129establishment of endothelial barrier (GO:0061028)2.35109726
130cellular response to thyroid hormone stimulus (GO:0097067)2.35057006
131regulation of T cell mediated cytotoxicity (GO:0001914)2.33144335
132positive regulation of astrocyte differentiation (GO:0048711)2.32578949
133uronic acid metabolic process (GO:0006063)2.32545843
134glucuronate metabolic process (GO:0019585)2.32545843
135regulation of leukocyte mediated cytotoxicity (GO:0001910)2.32148443
136regulation of transforming growth factor beta1 production (GO:0032908)2.31211931
137mannose metabolic process (GO:0006013)2.31104108
138lymphocyte chemotaxis (GO:0048247)2.29861711
139cellular extravasation (GO:0045123)2.29825325
140cellular glucuronidation (GO:0052695)2.29074895
141regulation of immunoglobulin secretion (GO:0051023)2.28484579
142alpha-beta T cell activation (GO:0046631)2.27967534
143regulation of necroptotic process (GO:0060544)2.27890070
144T cell migration (GO:0072678)2.26506470
145regulation of interleukin-2 biosynthetic process (GO:0045076)2.26362610
146regulation of interleukin-2 production (GO:0032663)2.26354339
147lymphocyte migration (GO:0072676)2.26345924
148positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.25732685
149CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.25726795
150regulation of defense response to virus by host (GO:0050691)2.25145543
151mammary gland epithelial cell proliferation (GO:0033598)2.22286336
152interleukin-1-mediated signaling pathway (GO:0070498)2.20090609
153hemidesmosome assembly (GO:0031581)2.19834501
154defense response to protozoan (GO:0042832)2.17518430
155negative regulation of T cell mediated immunity (GO:0002710)2.17055164
156response to thyroid hormone (GO:0097066)2.15716135
157regulation of apoptotic process involved in morphogenesis (GO:1902337)2.15441424
158negative regulation of complement activation (GO:0045916)2.14040540
159stress fiber assembly (GO:0043149)2.13948483
160positive regulation of cellular amide metabolic process (GO:0034250)2.13161727
161regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.11792984
162iron ion import (GO:0097286)2.11503940
163regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.11073602
164hypotonic response (GO:0006971)2.10739521
165detection of biotic stimulus (GO:0009595)2.09758747
166regulation of B cell receptor signaling pathway (GO:0050855)2.09232167
167macrophage activation involved in immune response (GO:0002281)2.09106903
168regulation of lymphocyte chemotaxis (GO:1901623)2.08917286
169negative regulation of toll-like receptor signaling pathway (GO:0034122)2.08895377
170negative regulation of humoral immune response (GO:0002921)2.08686437

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.08668213
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.14170660
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.87091537
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.75952528
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.58739650
6* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.43146823
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.13438018
8* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.97486286
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.79115911
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.76903436
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.67407532
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.35202629
13* RXR_22158963_ChIP-Seq_LIVER_Mouse2.27263473
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26654716
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.25919569
16RUNX_20019798_ChIP-Seq_JUKART_Human2.23008201
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.19385642
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.18755593
19* LXR_22158963_ChIP-Seq_LIVER_Mouse2.10581341
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.10366445
21CLOCK_20551151_ChIP-Seq_293T_Human2.05749082
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.05457437
23* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.04792720
24* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99611221
25MYC_22102868_ChIP-Seq_BL_Human1.99042368
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82278322
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.82146882
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81734646
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79541344
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72315696
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.71321541
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.70156800
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.68558199
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67013436
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.66403330
36* VDR_21846776_ChIP-Seq_THP-1_Human1.65339732
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63400790
38* LXR_22292898_ChIP-Seq_THP-1_Human1.62368103
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62126034
40* MAF_26560356_Chip-Seq_TH1_Human1.57586403
41* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55162778
42* VDR_24787735_ChIP-Seq_THP-1_Human1.50652101
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49703958
44* MYB_26560356_Chip-Seq_TH2_Human1.49558728
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48462092
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43144314
47NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42369131
48* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39102890
49* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38854577
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37721117
51MYB_26560356_Chip-Seq_TH1_Human1.36153727
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35912323
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34014461
54GATA1_19941826_ChIP-Seq_K562_Human1.32905995
55* FOXO3_23340844_ChIP-Seq_DLD1_Human1.32891825
56* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31568862
57ZNF263_19887448_ChIP-Seq_K562_Human1.28920899
58* TCF7_22412390_ChIP-Seq_EML_Mouse1.28622343
59* RUNX1_27514584_Chip-Seq_MCF-7_Human1.26702767
60ATF3_27146783_Chip-Seq_COLON_Human1.26199497
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.26047033
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25640354
63* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24881967
64P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23875585
65SPI1_23127762_ChIP-Seq_K562_Human1.20896505
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18438409
67* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16235734
68* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15291240
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15033281
70* NCOR1_26117541_ChIP-Seq_K562_Human1.14885861
71MAF_26560356_Chip-Seq_TH2_Human1.14438691
72CDX2_20551321_ChIP-Seq_CACO-2_Human1.14343127
73* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14024539
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11757654
75* CJUN_26792858_Chip-Seq_BT549_Human1.10422330
76* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10337897
77SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09808122
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09808122
79* UBF1/2_26484160_Chip-Seq_HMECs_Human1.07770314
80* ELK3_25401928_ChIP-Seq_HUVEC_Human1.06913099
81PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06574483
82* VDR_24763502_ChIP-Seq_THP-1_Human1.05456901
83* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05351045
84* TBX20_22080862_ChIP-Seq_HEART_Mouse1.05290030
85* TBX20_22328084_ChIP-Seq_HEART_Mouse1.05290030
86* PU_27001747_Chip-Seq_BMDM_Mouse1.04927435
87* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04825591
88GATA1_19941827_ChIP-Seq_MEL_Mouse1.04594161
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04351851
90NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04307125
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03364763
92* KDM2B_26808549_Chip-Seq_DND41_Human1.03156054
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02822907
94* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02476155
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02467714
96ESR1_20079471_ChIP-ChIP_T-47D_Human1.02177158
97* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01313848
98* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97042887
99RUNX1_22412390_ChIP-Seq_EML_Mouse0.95727133
100SOX2_20726797_ChIP-Seq_SW620_Human0.94835318
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93980376
102NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93980376
103RACK7_27058665_Chip-Seq_MCF-7_Human0.93224186
104* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91050951
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89591559
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89324243
107* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88686839
108SCL_19346495_ChIP-Seq_HPC-7_Human0.87968176
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87793631
110GATA3_27048872_Chip-Seq_THYMUS_Human0.87203552
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87054339
112EGR1_19032775_ChIP-ChIP_M12_Human0.86822045
113GATA2_19941826_ChIP-Seq_K562_Human0.85858898
114* KDM2B_26808549_Chip-Seq_JURKAT_Human0.85713076
115SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84422148
116NOTCH1_21737748_ChIP-Seq_TLL_Human0.83114302
117SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82800201
118UTX_26944678_Chip-Seq_JUKART_Human0.82338045
119CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81936619
120* KDM2B_26808549_Chip-Seq_K562_Human0.81776480
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81454818
122* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80670748
123* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80531859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system3.21081432
2MP0001835_abnormal_antigen_presentation3.08887306
3MP0003436_decreased_susceptibility_to3.07203845
4MP0003724_increased_susceptibility_to3.07155441
5MP0004510_myositis2.76504910
6MP0002138_abnormal_hepatobiliary_system2.73228584
7MP0009785_altered_susceptibility_to2.64969866
8MP0002254_reproductive_system_inflammat2.64364570
9MP0003303_peritoneal_inflammation2.59489731
10* MP0005387_immune_system_phenotype2.56884904
11* MP0001790_abnormal_immune_system2.56884904
12MP0005671_abnormal_response_to2.43854850
13MP0002148_abnormal_hypersensitivity_rea2.37538784
14* MP0005000_abnormal_immune_tolerance2.37192497
15MP0002405_respiratory_system_inflammati2.14123724
16* MP0001800_abnormal_humoral_immune2.11581291
17MP0001853_heart_inflammation2.09984504
18MP0002877_abnormal_melanocyte_morpholog2.08549676
19MP0002419_abnormal_innate_immunity2.07302773
20MP0004947_skin_inflammation2.05853902
21MP0006082_CNS_inflammation2.03901976
22* MP0002723_abnormal_immune_serum1.99325111
23MP0002796_impaired_skin_barrier1.98935036
24* MP0002452_abnormal_antigen_presenting1.96730720
25MP0005025_abnormal_response_to1.95519828
26MP0003300_gastrointestinal_ulcer1.94749230
27MP0005275_abnormal_skin_tensile1.88614768
28MP0010155_abnormal_intestine_physiology1.87983997
29MP0002166_altered_tumor_susceptibility1.86267453
30MP0005058_abnormal_lysosome_morphology1.84953400
31MP0003453_abnormal_keratinocyte_physiol1.81908728
32MP0005076_abnormal_cell_differentiation1.76030824
33MP0005451_abnormal_body_composition1.75516133
34MP0009278_abnormal_bone_marrow1.73387344
35MP0002006_tumorigenesis1.72809470
36* MP0001819_abnormal_immune_cell1.71913313
37MP0002009_preneoplasia1.71725446
38* MP0002420_abnormal_adaptive_immunity1.71380466
39MP0003763_abnormal_thymus_physiology1.69551629
40MP0001533_abnormal_skeleton_physiology1.66712615
41MP0009840_abnormal_foam_cell1.66322545
42MP0009764_decreased_sensitivity_to1.60075026
43MP0002933_joint_inflammation1.58948576
44MP0005360_urolithiasis1.56870564
45MP0008438_abnormal_cutaneous_collagen1.56487606
46MP0001845_abnormal_inflammatory_respons1.55935528
47MP0003448_altered_tumor_morphology1.55255390
48MP0008875_abnormal_xenobiotic_pharmacok1.47874655
49MP0003075_altered_response_to1.47595943
50MP0001873_stomach_inflammation1.46217837
51MP0005365_abnormal_bile_salt1.45981116
52MP0002998_abnormal_bone_remodeling1.43611751
53MP0003705_abnormal_hypodermis_morpholog1.41897437
54MP0003183_abnormal_peptide_metabolism1.39485830
55MP0002139_abnormal_hepatobiliary_system1.38592325
56MP0005085_abnormal_gallbladder_physiolo1.38093644
57MP0003566_abnormal_cell_adhesion1.37839810
58MP0010352_gastrointestinal_tract_polyps1.37759728
59MP0001881_abnormal_mammary_gland1.35018973
60MP0005397_hematopoietic_system_phenotyp1.31670757
61MP0001545_abnormal_hematopoietic_system1.31670757
62* MP0000716_abnormal_immune_system1.26480756
63MP0003172_abnormal_lysosome_physiology1.26311840
64MP0000343_altered_response_to1.24688494
65MP0010329_abnormal_lipoprotein_level1.23935743
66MP0005464_abnormal_platelet_physiology1.20482061
67MP0008469_abnormal_protein_level1.19998774
68MP0004381_abnormal_hair_follicle1.17997943
69MP0003828_pulmonary_edema1.16978680
70* MP0002398_abnormal_bone_marrow1.16781183
71MP0001851_eye_inflammation1.16205131
72MP0000858_altered_metastatic_potential1.16183786
73MP0010678_abnormal_skin_adnexa1.15908821
74MP0000249_abnormal_blood_vessel1.15464682
75MP0003950_abnormal_plasma_membrane1.13839454
76MP0000609_abnormal_liver_physiology1.13154872
77MP0005310_abnormal_salivary_gland1.12491716
78MP0009333_abnormal_splenocyte_physiolog1.11650791
79MP0003091_abnormal_cell_migration1.10594097
80MP0003252_abnormal_bile_duct1.09949997
81MP0003191_abnormal_cellular_cholesterol1.09942064
82MP0004808_abnormal_hematopoietic_stem1.08311588
83MP0003656_abnormal_erythrocyte_physiolo1.06755140
84MP0003866_abnormal_defecation1.06679426
85MP0000383_abnormal_hair_follicle1.06358209
86MP0004019_abnormal_vitamin_homeostasis1.06298503
87MP0005023_abnormal_wound_healing1.05153334
88MP0005501_abnormal_skin_physiology1.05033454
89MP0005257_abnormal_intraocular_pressure1.04908302
90MP0005166_decreased_susceptibility_to1.03319303
91MP0005670_abnormal_white_adipose1.01617745
92MP0005375_adipose_tissue_phenotype1.01072709
93MP0001348_abnormal_lacrimal_gland1.01070254
94MP0005164_abnormal_response_to1.00288682
95MP0005390_skeleton_phenotype0.99066584
96MP0010368_abnormal_lymphatic_system0.97648094
97* MP0002722_abnormal_immune_system0.97408974
98* MP0000689_abnormal_spleen_morphology0.97194075
99MP0005409_darkened_coat_color0.97132962
100MP0003045_fibrosis0.96574658
101MP0005666_abnormal_adipose_tissue0.96078705
102MP0001958_emphysema0.95734077
103MP0004883_abnormal_blood_vessel0.94874552
104MP0000003_abnormal_adipose_tissue0.93585231
105* MP0002429_abnormal_blood_cell0.91812190
106MP0009931_abnormal_skin_appearance0.91318047
107MP0002277_abnormal_respiratory_mucosa0.90306115
108MP0001346_abnormal_lacrimal_gland0.88908923
109MP0005167_abnormal_blood-brain_barrier0.87587833
110MP0000604_amyloidosis0.86570891
111MP0002060_abnormal_skin_morphology0.86517268
112MP0009763_increased_sensitivity_to0.86421700
113MP0004782_abnormal_surfactant_physiolog0.85741338
114MP0001879_abnormal_lymphatic_vessel0.84482303
115MP0000627_abnormal_mammary_gland0.83831724
116MP0009115_abnormal_fat_cell0.82714682
117MP0000678_abnormal_parathyroid_gland0.82487238
118MP0010234_abnormal_vibrissa_follicle0.81463963
119MP0008961_abnormal_basal_metabolism0.80906285
120MP0008260_abnormal_autophagy0.79069435
121MP0003279_aneurysm0.78432807
122MP0001216_abnormal_epidermal_layer0.78207484
123MP0005165_increased_susceptibility_to0.77678251
124MP0002136_abnormal_kidney_physiology0.76288527
125MP0004264_abnormal_extraembryonic_tissu0.76019545

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)5.55368786
2Retrobulbar optic neuritis (HP:0100654)5.55368786
3Orchitis (HP:0100796)5.39940878
4Myositis (HP:0100614)4.91425269
5Eczematoid dermatitis (HP:0000976)4.65957419
6Myocardial infarction (HP:0001658)4.20365418
7Keratoconjunctivitis sicca (HP:0001097)3.90134024
8Arterial thrombosis (HP:0004420)3.67874975
9Keratoconjunctivitis (HP:0001096)3.55169172
10Increased IgM level (HP:0003496)3.49492741
11Recurrent gram-negative bacterial infections (HP:0005420)3.41949685
12Pulmonary infiltrates (HP:0002113)3.36067246
13Persistence of primary teeth (HP:0006335)3.27280204
14Recurrent fungal infections (HP:0002841)3.26171948
15Gastrointestinal infarctions (HP:0005244)3.22213832
16Esophageal varix (HP:0002040)3.12391407
17Increased density of long bones (HP:0006392)3.09870809
18Alopecia of scalp (HP:0002293)3.09859946
19Abnormality of nail color (HP:0100643)3.07677333
20Mediastinal lymphadenopathy (HP:0100721)3.06513863
21Pustule (HP:0200039)3.05299990
22Elevated erythrocyte sedimentation rate (HP:0003565)3.00850306
23Vasculitis (HP:0002633)2.95815166
24Anorexia (HP:0002039)2.94191717
25Polycythemia (HP:0001901)2.92357313
26Autoimmune thrombocytopenia (HP:0001973)2.88732447
27Recurrent bacterial skin infections (HP:0005406)2.88662023
28Interstitial pulmonary disease (HP:0006530)2.88407160
29Hemoptysis (HP:0002105)2.83204113
30Joint swelling (HP:0001386)2.78624318
31Recurrent abscess formation (HP:0002722)2.78450797
32Pulmonary embolism (HP:0002204)2.75790986
33Stomatitis (HP:0010280)2.70485152
34Segmental peripheral demyelination/remyelination (HP:0003481)2.66506157
35Right ventricular cardiomyopathy (HP:0011663)2.63533652
36Abnormality of liposaccharide metabolism (HP:0010968)2.62038114
37Abnormality of glycosphingolipid metabolism (HP:0004343)2.62038114
38Abnormality of glycolipid metabolism (HP:0010969)2.62038114
39Gingival bleeding (HP:0000225)2.61539422
40Abnormality of T cell number (HP:0011839)2.56116293
41Deep venous thrombosis (HP:0002625)2.53367135
42Glomerulonephritis (HP:0000099)2.52227301
43IgA deficiency (HP:0002720)2.48778099
44Abnormality of the nasal septum (HP:0000419)2.46921219
45Dysostosis multiplex (HP:0000943)2.46911180
46Gangrene (HP:0100758)2.46315481
47Abnormality of macrophages (HP:0004311)2.45982306
48Thrombophlebitis (HP:0004418)2.41062538
49Abnormality of proline metabolism (HP:0010907)2.39919294
50Hydroxyprolinuria (HP:0003080)2.39919294
51Xanthomatosis (HP:0000991)2.33715989
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.30651275
53Abnormality of the pericardium (HP:0001697)2.30173029
54Nasal polyposis (HP:0100582)2.20277693
55Onycholysis (HP:0001806)2.20092104
56Joint hemorrhage (HP:0005261)2.19867055
57Fatigue (HP:0012378)2.18143723
58T lymphocytopenia (HP:0005403)2.17503923
59Recurrent skin infections (HP:0001581)2.16909237
60Systemic lupus erythematosus (HP:0002725)2.16637948
61Peritonitis (HP:0002586)2.15112757
62Abnormal gallbladder physiology (HP:0012438)2.14004051
63Cholecystitis (HP:0001082)2.14004051
64Abnormality of the nasal mucosa (HP:0000433)2.13806841
65Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.12696290
66Gingivitis (HP:0000230)2.11306630
67Tetraparesis (HP:0002273)2.11004748
68Broad face (HP:0000283)2.09574283
69Premature loss of primary teeth (HP:0006323)2.09110786
70Distal lower limb amyotrophy (HP:0008944)2.08697038
71Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07398958
72Cerebral aneurysm (HP:0004944)2.06293399
73Bilateral sensorineural hearing impairment (HP:0008619)2.05531690
74Increased connective tissue (HP:0009025)2.05046391
75Recurrent cutaneous fungal infections (HP:0011370)2.04211613
76Chronic mucocutaneous candidiasis (HP:0002728)2.04211613
77Autoimmune hemolytic anemia (HP:0001890)2.03946236
78Osteolytic defects of the hand bones (HP:0009699)2.03455218
79Osteolytic defects of the phalanges of the hand (HP:0009771)2.03455218
80Abnormality of monocarboxylic acid metabolism (HP:0010996)2.02790324
81Neurofibrillary tangles (HP:0002185)2.02090041
82Abnormal blistering of the skin (HP:0008066)2.01966601
83Protrusio acetabuli (HP:0003179)2.01412652
84Hypergammaglobulinemia (HP:0010702)2.00768912
85Abnormality of T cells (HP:0002843)1.99596847
86Ankyloglossia (HP:0010296)1.98814739
87Abnormality of oral frenula (HP:0000190)1.98809232
88Milia (HP:0001056)1.98217241
89Mitral stenosis (HP:0001718)1.98187531
90Obstructive sleep apnea (HP:0002870)1.97953014
91Cheilitis (HP:0100825)1.97108205
92Periodontitis (HP:0000704)1.96563361
93Urinary glycosaminoglycan excretion (HP:0003541)1.96449542
94Mucopolysacchariduria (HP:0008155)1.96449542
95Encephalitis (HP:0002383)1.95556167
96Menorrhagia (HP:0000132)1.94781234
97Plantar hyperkeratosis (HP:0007556)1.94583645
98Nail dystrophy (HP:0008404)1.92701961
99Gastrointestinal stroma tumor (HP:0100723)1.92683614
100Abnormality of the common coagulation pathway (HP:0010990)1.91995594
101Vertebral compression fractures (HP:0002953)1.91359108
102Increased cerebral lipofuscin (HP:0011813)1.91222690
103Increased mean platelet volume (HP:0011877)1.91029357
104Axonal loss (HP:0003447)1.89817395
105Arthralgia (HP:0002829)1.89661608
106IgM deficiency (HP:0002850)1.89640661
107Asymmetric septal hypertrophy (HP:0001670)1.89618109
108Spondylolisthesis (HP:0003302)1.89373579
109Colitis (HP:0002583)1.89343576
110Abnormal platelet volume (HP:0011876)1.89196563
111Meningitis (HP:0001287)1.88714591
112Leukocytosis (HP:0001974)1.88392351
113Loss of speech (HP:0002371)1.86041297
114Recurrent viral infections (HP:0004429)1.85781291
115Vascular calcification (HP:0004934)1.85716197
116Intrahepatic cholestasis (HP:0001406)1.85249733
117Inflammation of the large intestine (HP:0002037)1.85004994
118Abnormal delayed hypersensitivity skin test (HP:0002963)1.84848299
119Spontaneous hematomas (HP:0007420)1.84134377
120Thick nail (HP:0001805)1.83752531
121Increased IgE level (HP:0003212)1.83669886
122Distal lower limb muscle weakness (HP:0009053)1.82540716
123Dilatation of the ascending aorta (HP:0005111)1.82424336
124Lip pit (HP:0100267)1.81791045
125Nephritis (HP:0000123)1.81722671
126Prostate neoplasm (HP:0100787)1.81227108
127Abnormality of T cell physiology (HP:0011840)1.81051879
128Emphysema (HP:0002097)1.80836574
129Exercise-induced myalgia (HP:0003738)1.80829728
130Erythema (HP:0010783)1.80720034
131Hemorrhage of the eye (HP:0011885)1.79569951
132Chronic diarrhea (HP:0002028)1.79367690
133Palmoplantar hyperkeratosis (HP:0000972)1.78194047
134Cardiovascular calcification (HP:0011915)1.77928285
135Abnormality of polysaccharide metabolism (HP:0011012)1.77726939
136Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77726939
137Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77726939
138Bone pain (HP:0002653)1.77040343
139Glomerulopathy (HP:0100820)1.76375916
140Complement deficiency (HP:0004431)1.76000532
141Atrophic scars (HP:0001075)1.75700347
142Arterial tortuosity (HP:0005116)1.74617968
143Abnormality of complement system (HP:0005339)1.74252911
144Chronic otitis media (HP:0000389)1.73496698
145Flat acetabular roof (HP:0003180)1.69908562
146Advanced eruption of teeth (HP:0006288)1.67057401
147Malnutrition (HP:0004395)1.66616661
148Aortic dissection (HP:0002647)1.65969750
149Aneurysm (HP:0002617)1.65938687
150Increased serum ferritin (HP:0003281)1.65042409
151Recurrent bronchitis (HP:0002837)1.64848754
152Amyloidosis (HP:0011034)1.64532748
153Restrictive lung disease (HP:0002091)1.64010195
154Abnormality of the fingertips (HP:0001211)1.61631903

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.41740419
2TXK3.61040164
3PRPF4B3.37092533
4MAP4K12.68607139
5MAPK152.65984137
6IRAK32.65905394
7TBK12.58108438
8IKBKB2.50169072
9JAK32.43130896
10TAOK32.42704220
11JAK12.40400973
12EPHB12.29526878
13CHUK2.15547265
14TYK22.12688398
15EPHA32.03405564
16BMX1.97438620
17IKBKE1.97125136
18FGFR41.95161113
19PIM21.94544871
20RIPK11.79657920
21PIM11.63860487
22FGFR31.53983260
23CSK1.53067182
24ITK1.46474594
25STK101.45473942
26EEF2K1.45172265
27CDC42BPA1.44164283
28SIK11.38043843
29MAP3K31.30244911
30MST41.29426423
31MAP3K111.26074033
32ICK1.25482101
33MAP3K131.20665612
34RIPK41.19136544
35CDK61.17827190
36JAK21.16593633
37TRIB31.16508927
38ERN11.15562957
39ZAP701.12930876
40MAPKAPK31.11322689
41NEK91.04905923
42GSK3A1.03194849
43PTK61.02021098
44MAP2K61.01565629
45SIK31.01083585
46TGFBR21.00648567
47NLK0.98729265
48TRPM70.98161811
49HCK0.97900387
50STK240.95693033
51MOS0.95602924
52KSR20.92534308
53TEC0.91977146
54EPHA20.91174597
55MST1R0.89213492
56BLK0.87421355
57LATS20.86169811
58MAP2K30.85090924
59DMPK0.84761242
60MATK0.82783877
61MTOR0.80968017
62LCK0.80846998
63MAPK110.80196924
64FGR0.78206362
65BMPR20.77827951
66IRAK40.75983824
67MAP3K90.75431715
68NME20.72296852
69MAP2K20.72271093
70GRK60.72016482
71PDGFRB0.70375863
72BTK0.70100468
73MARK20.69744263
74RPS6KA40.69664117
75MAPKAPK20.69302599
76PDPK10.69129771
77SMG10.67850793
78SYK0.67638879
79MARK30.66678974
80PDK10.66136010
81PDK20.66025509
82PRKCQ0.64715352
83RET0.64466492
84DDR20.63466766
85TAOK20.62633506
86LRRK20.59435035
87PIK3CG0.58198259
88PKN20.57871881
89TTN0.57515093
90WNK10.56884488
91MET0.56202360
92RPS6KA10.55856221
93MAP3K70.55374971
94NEK60.54199221
95ARAF0.54174352
96KDR0.53736764
97MAP3K60.53516303
98IRAK10.52921290
99ABL10.52798013
100STK30.51160431
101MAP3K10.50128890
102KIT0.48956412
103IRAK20.47641605
104SIK20.45452225
105PTK20.45278629
106EGFR0.43931804
107DYRK1B0.43434088
108CDK120.43396930
109TAOK10.42933163
110CSF1R0.42855831
111HIPK20.42340974
112MAP3K20.41751427
113NTRK10.41426472
114MAPK40.40813776
115PAK40.40615050
116PRKD20.40129710
117LYN0.40037687
118MAP3K50.38542887
119RPS6KA60.37964136
120SGK30.37869419
121INSR0.37224668
122FES0.34618036
123PTK2B0.34131869
124PDGFRA0.32919964
125IGF1R0.32681742
126NUAK10.32407360
127MAPK70.32173885
128FER0.31153124
129MAPK30.30774791
130MAPK120.29312856

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.03278981
2Graft-versus-host disease_Homo sapiens_hsa053322.76232668
3Allograft rejection_Homo sapiens_hsa053302.43376427
4Leishmaniasis_Homo sapiens_hsa051402.27268494
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.22999373
6Osteoclast differentiation_Homo sapiens_hsa043802.22995487
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.21559665
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.03956139
9TNF signaling pathway_Homo sapiens_hsa046682.01021824
10Nitrogen metabolism_Homo sapiens_hsa009101.93379285
11Other glycan degradation_Homo sapiens_hsa005111.91850413
12Staphylococcus aureus infection_Homo sapiens_hsa051501.85215136
13Measles_Homo sapiens_hsa051621.75479937
14Legionellosis_Homo sapiens_hsa051341.63004737
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.56466326
16Rheumatoid arthritis_Homo sapiens_hsa053231.55765093
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.55745875
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55034525
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.54950682
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54281127
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50410907
22Toxoplasmosis_Homo sapiens_hsa051451.49651400
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49403214
24T cell receptor signaling pathway_Homo sapiens_hsa046601.45090096
25Complement and coagulation cascades_Homo sapiens_hsa046101.42931520
26Malaria_Homo sapiens_hsa051441.36461120
27Autoimmune thyroid disease_Homo sapiens_hsa053201.35733004
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.35176152
29Arginine biosynthesis_Homo sapiens_hsa002201.34884948
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31970684
31B cell receptor signaling pathway_Homo sapiens_hsa046621.28876049
32Primary immunodeficiency_Homo sapiens_hsa053401.27383461
33Type I diabetes mellitus_Homo sapiens_hsa049401.24955083
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23543169
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.22400749
36Viral myocarditis_Homo sapiens_hsa054161.22009462
37Renal cell carcinoma_Homo sapiens_hsa052111.18431524
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17484990
39Influenza A_Homo sapiens_hsa051641.16147773
40Pertussis_Homo sapiens_hsa051331.15951536
41Apoptosis_Homo sapiens_hsa042101.13298425
42African trypanosomiasis_Homo sapiens_hsa051431.08723464
43Antigen processing and presentation_Homo sapiens_hsa046121.06803614
44Chemokine signaling pathway_Homo sapiens_hsa040621.06028470
45Tuberculosis_Homo sapiens_hsa051521.04565197
46Prolactin signaling pathway_Homo sapiens_hsa049171.00713191
47Shigellosis_Homo sapiens_hsa051310.97976260
48Salmonella infection_Homo sapiens_hsa051320.96583071
49Fructose and mannose metabolism_Homo sapiens_hsa000510.95954818
50Hematopoietic cell lineage_Homo sapiens_hsa046400.95246364
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95180604
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.94953167
53Acute myeloid leukemia_Homo sapiens_hsa052210.94896606
54Bladder cancer_Homo sapiens_hsa052190.93526969
55Hepatitis B_Homo sapiens_hsa051610.89489195
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.87488671
57Non-small cell lung cancer_Homo sapiens_hsa052230.87026741
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86316111
59GnRH signaling pathway_Homo sapiens_hsa049120.85795531
60Starch and sucrose metabolism_Homo sapiens_hsa005000.85419136
61Amoebiasis_Homo sapiens_hsa051460.81329223
62Herpes simplex infection_Homo sapiens_hsa051680.80223745
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78445535
64Chemical carcinogenesis_Homo sapiens_hsa052040.77999576
65Fatty acid biosynthesis_Homo sapiens_hsa000610.77738142
66mTOR signaling pathway_Homo sapiens_hsa041500.77643895
67ErbB signaling pathway_Homo sapiens_hsa040120.75898083
68Caffeine metabolism_Homo sapiens_hsa002320.75586155
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74318139
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.73461649
71Chronic myeloid leukemia_Homo sapiens_hsa052200.73242517
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73208822
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71427927
74Hepatitis C_Homo sapiens_hsa051600.71280969
75Insulin resistance_Homo sapiens_hsa049310.71237483
76Insulin signaling pathway_Homo sapiens_hsa049100.70085351
77Asthma_Homo sapiens_hsa053100.69940922
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68835021
79* Circadian rhythm_Homo sapiens_hsa047100.68346329
80Tryptophan metabolism_Homo sapiens_hsa003800.67636107
81Small cell lung cancer_Homo sapiens_hsa052220.67280631
82PPAR signaling pathway_Homo sapiens_hsa033200.66155314
83Adherens junction_Homo sapiens_hsa045200.62778865
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61537471
85ECM-receptor interaction_Homo sapiens_hsa045120.61329429
86Prion diseases_Homo sapiens_hsa050200.60964303
87Choline metabolism in cancer_Homo sapiens_hsa052310.60646725
88Prostate cancer_Homo sapiens_hsa052150.60534331
89Galactose metabolism_Homo sapiens_hsa000520.59563090
90Epstein-Barr virus infection_Homo sapiens_hsa051690.59406571
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59221142
92HIF-1 signaling pathway_Homo sapiens_hsa040660.58566636
93Retinol metabolism_Homo sapiens_hsa008300.58558491
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56467485
95Proteoglycans in cancer_Homo sapiens_hsa052050.56251722
96MicroRNAs in cancer_Homo sapiens_hsa052060.55432985
97Pentose phosphate pathway_Homo sapiens_hsa000300.55285174
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.54838887
99Thyroid cancer_Homo sapiens_hsa052160.54006072
100Estrogen signaling pathway_Homo sapiens_hsa049150.53691436
101Viral carcinogenesis_Homo sapiens_hsa052030.53337577
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53336752
103Phenylalanine metabolism_Homo sapiens_hsa003600.53020442
104Endocytosis_Homo sapiens_hsa041440.52516407
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52294621
106VEGF signaling pathway_Homo sapiens_hsa043700.52148025
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.51756249
108Focal adhesion_Homo sapiens_hsa045100.51254379
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.49354093
110Pancreatic cancer_Homo sapiens_hsa052120.48430429
111MAPK signaling pathway_Homo sapiens_hsa040100.47118205
112HTLV-I infection_Homo sapiens_hsa051660.46655678
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46347111
114Platelet activation_Homo sapiens_hsa046110.46227158
115Dorso-ventral axis formation_Homo sapiens_hsa043200.46127546
116Bile secretion_Homo sapiens_hsa049760.45953651
117FoxO signaling pathway_Homo sapiens_hsa040680.45303057
118Fatty acid degradation_Homo sapiens_hsa000710.41983189
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41960544
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.41717821
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41106549
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39722793
123Notch signaling pathway_Homo sapiens_hsa043300.38320603
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37761584
125Arginine and proline metabolism_Homo sapiens_hsa003300.36334169
126Phagosome_Homo sapiens_hsa041450.36009113
127Lysosome_Homo sapiens_hsa041420.34392674
128Type II diabetes mellitus_Homo sapiens_hsa049300.32478739

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »