ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chromosome organization involved in meiosis (GO:0070192)	9.76864452
2	piRNA metabolic process (GO:0034587)	9.27729208
3	synaptonemal complex assembly (GO:0007130)	9.13034573
4	male meiosis I (GO:0007141)	8.87838693
5	male meiosis (GO:0007140)	8.37626635
6	synaptonemal complex organization (GO:0070193)	8.01394097
7	DNA synthesis involved in DNA repair (GO:0000731)	7.61484980
8	meiosis I (GO:0007127)	7.16079968
9	DNA methylation involved in gamete generation (GO:0043046)	7.12796222
10	meiotic nuclear division (GO:0007126)	6.82562158
11	meiotic chromosome segregation (GO:0045132)	6.37577331
12	meiotic cell cycle process (GO:1903046)	5.91853180
13	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	5.82950091
14	response to pheromone (GO:0019236)	5.67999774
15	reciprocal meiotic recombination (GO:0007131)	5.56083068
16	reciprocal DNA recombination (GO:0035825)	5.56083068
17	regulation of retinoic acid receptor signaling pathway (GO:0048385)	4.85356004
18	resolution of meiotic recombination intermediates (GO:0000712)	4.71734669
19	sister chromatid cohesion (GO:0007062)	4.59509691
20	rRNA methylation (GO:0031167)	4.40444055
21	DNA replication checkpoint (GO:0000076)	4.28353505
22	rRNA modification (GO:0000154)	4.26159960
23	spermatid development (GO:0007286)	4.19114062
24	chaperone-mediated protein complex assembly (GO:0051131)	3.99636443
25	histone exchange (GO:0043486)	3.95611725
26	binding of sperm to zona pellucida (GO:0007339)	3.86905416
27	DNA replication initiation (GO:0006270)	3.73493345
28	gene silencing by RNA (GO:0031047)	3.70821187
29	sperm motility (GO:0030317)	3.68014549
30	meiotic cell cycle (GO:0051321)	3.51699589
31	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.45931264
32	sperm-egg recognition (GO:0035036)	3.45787295
33	microtubule depolymerization (GO:0007019)	3.41584015
34	multicellular organism reproduction (GO:0032504)	3.39682509
35	cellular response to electrical stimulus (GO:0071257)	3.37296988
36	somite rostral/caudal axis specification (GO:0032525)	3.36110150
37	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.33800922
38	female gamete generation (GO:0007292)	3.26673835
39	acrosome reaction (GO:0007340)	3.25255557
40	DNA replication-dependent nucleosome assembly (GO:0006335)	3.21852221
41	DNA replication-dependent nucleosome organization (GO:0034723)	3.21852221
42	DNA alkylation (GO:0006305)	3.19129301
43	DNA methylation (GO:0006306)	3.19129301
44	nucleotide transmembrane transport (GO:1901679)	3.17695943
45	motile cilium assembly (GO:0044458)	3.14735099
46	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.07693956
47	snRNA transcription (GO:0009301)	3.07559648
48	chromosome organization (GO:0051276)	3.05071927
49	cilium or flagellum-dependent cell motility (GO:0001539)	3.03094488
50	DNA strand renaturation (GO:0000733)	2.96486146
51	CENP-A containing nucleosome assembly (GO:0034080)	2.90780354
52	cerebellar Purkinje cell differentiation (GO:0021702)	2.89877868
53	regulation of centriole replication (GO:0046599)	2.88057863
54	organic cation transport (GO:0015695)	2.87500208
55	fertilization (GO:0009566)	2.86391634
56	tRNA methylation (GO:0030488)	2.86156505
57	vagina development (GO:0060068)	2.85649055
58	mitochondrial fusion (GO:0008053)	2.85504297
59	chromatin remodeling at centromere (GO:0031055)	2.80858508
60	cell-cell recognition (GO:0009988)	2.79508673
61	L-methionine salvage (GO:0071267)	2.75996714
62	L-methionine biosynthetic process (GO:0071265)	2.75996714
63	amino acid salvage (GO:0043102)	2.75996714
64	mitotic chromosome condensation (GO:0007076)	2.75445891
65	centriole assembly (GO:0098534)	2.74951567
66	mitotic sister chromatid cohesion (GO:0007064)	2.73081227
67	regulation of translational fidelity (GO:0006450)	2.71717334
68	germ cell development (GO:0007281)	2.70568833
69	DNA packaging (GO:0006323)	2.68178173
70	protein localization to chromosome (GO:0034502)	2.66889035
71	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.65525506
72	regulation of meiotic cell cycle (GO:0051445)	2.65203834
73	transcription from mitochondrial promoter (GO:0006390)	2.62942532
74	DNA biosynthetic process (GO:0071897)	2.62360454
75	mitotic sister chromatid segregation (GO:0000070)	2.62020486
76	DNA replication-independent nucleosome organization (GO:0034724)	2.61189565
77	DNA replication-independent nucleosome assembly (GO:0006336)	2.61189565
78	regulation of meiosis I (GO:0060631)	2.59935051
79	nuclear division (GO:0000280)	2.55699486
80	RNA methylation (GO:0001510)	2.52883622
81	primitive streak formation (GO:0090009)	2.52461968
82	male gamete generation (GO:0048232)	2.50708235
83	spermatogenesis (GO:0007283)	2.50369412
84	potassium ion export (GO:0071435)	2.49833845
85	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.49095455
86	histone H3-K9 demethylation (GO:0033169)	2.47737618
87	gamete generation (GO:0007276)	2.47452355
88	opioid receptor signaling pathway (GO:0038003)	2.47452340
89	regulation of chromatin binding (GO:0035561)	2.46295680
90	DNA methylation or demethylation (GO:0044728)	2.46192222
91	gene silencing (GO:0016458)	2.44645639
92	positive regulation of catecholamine secretion (GO:0033605)	2.44234815
93	regulation of cilium movement (GO:0003352)	2.43193660
94	acrosome assembly (GO:0001675)	2.41262736
95	organelle fission (GO:0048285)	2.40095305
96	DNA catabolic process, exonucleolytic (GO:0000738)	2.40095263
97	proteasome assembly (GO:0043248)	2.39481273
98	attachment of spindle microtubules to kinetochore (GO:0008608)	2.39065890
99	negative regulation of chromosome segregation (GO:0051985)	2.38536729
100	synapsis (GO:0007129)	11.2013025

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.48195575
2	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	4.20181186
3	E2F7_22180533_ChIP-Seq_HELA_Human	3.91086197
4	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.63774225
5	TP63_19390658_ChIP-ChIP_HaCaT_Human	3.01188215
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.79409088
7	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.78343753
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.65567322
9	XRN2_22483619_ChIP-Seq_HELA_Human	2.61211176
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.52938390
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.46642561
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.39981369
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.38156003
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.31905605
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.25855786
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.24444339
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.24186258
18	DCP1A_22483619_ChIP-Seq_HELA_Human	2.06336460
19	ERA_21632823_ChIP-Seq_H3396_Human	2.03975758
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.02654048
21	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.94487518
22	GABP_19822575_ChIP-Seq_HepG2_Human	1.92209759
23	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.92125048
24	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.87666159
25	ZNF263_19887448_ChIP-Seq_K562_Human	1.83961691
26	P68_20966046_ChIP-Seq_HELA_Human	1.81539467
27	E2F1_20622854_ChIP-Seq_HELA_Human	1.77802015
28	PHF8_20622854_ChIP-Seq_HELA_Human	1.76838057
29	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.75255927
30	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.74149940
31	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.67852126
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.66508095
33	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.64687362
34	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.58681527
35	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.57726722
36	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.56403186
37	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.55216990
38	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.55111303
39	OCT4_20526341_ChIP-Seq_ESCs_Human	1.53494647
40	CTCF_20526341_ChIP-Seq_ESCs_Human	1.51276455
41	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.50596386
42	RAC3_21632823_ChIP-Seq_H3396_Human	1.49809536
43	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.49021164
44	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.47536482
45	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.46747565
46	VDR_23849224_ChIP-Seq_CD4+_Human	1.45103218
47	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.42635759
48	MYC_18940864_ChIP-ChIP_HL60_Human	1.42221599
49	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.42214189
50	BCL6_27268052_Chip-Seq_Bcells_Human	1.40263744
51	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.38322534
52	NANOG_20526341_ChIP-Seq_ESCs_Human	1.36949566
53	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.36926408
54	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.35208638
55	KDM5A_27292631_Chip-Seq_BREAST_Human	1.32150004
56	BCOR_27268052_Chip-Seq_Bcells_Human	1.30963183
57	IGF1R_20145208_ChIP-Seq_DFB_Human	1.26682588
58	CTCF_21964334_Chip-Seq_Bcells_Human	1.25028908
59	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.24227681
60	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.23944414
61	CTCF_27219007_Chip-Seq_Bcells_Human	1.23584984
62	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.22444484
63	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.20303932
64	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.20019517
65	P53_21459846_ChIP-Seq_SAOS-2_Human	1.19839256
66	MYC_19829295_ChIP-Seq_ESCs_Human	1.19246495
67	TP53_22573176_ChIP-Seq_HFKS_Human	1.18430327
68	VDR_21846776_ChIP-Seq_THP-1_Human	1.16998157
69	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.16184536
70	FOXP3_21729870_ChIP-Seq_TREG_Human	1.13677190
71	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.10163811
72	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.09157239
73	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.07294834
74	RNF2_27304074_Chip-Seq_NSC_Mouse	1.06743971
75	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.04443398
76	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.04060596
77	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.01337442
78	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.01197398
79	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.00888137
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00681943
81	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.00042762
82	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.99843290
83	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.99278248
84	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.99186305
85	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.97641543
86	SMC4_20622854_ChIP-Seq_HELA_Human	0.97635133
87	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.96563352
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95430987
89	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.95158268
90	OCT4_19829295_ChIP-Seq_ESCs_Human	0.92518094
91	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.92257612
92	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.92251737
93	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.90907056
94	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.89874772
95	CIITA_25753668_ChIP-Seq_RAJI_Human	0.89850768
96	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.89417230
97	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88702087
98	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.87495178
99	TAF2_19829295_ChIP-Seq_ESCs_Human	0.87396485
100	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.87361354

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005423_abnormal_somatic_nervous	4.15674578
2	MP0002160_abnormal_reproductive_system	4.01407682
3	MP0008877_abnormal_DNA_methylation	3.85243304
4	MP0001986_abnormal_taste_sensitivity	3.82010526
5	MP0005410_abnormal_fertilization	3.60964286
6	MP0003890_abnormal_embryonic-extraembry	3.59440857
7	MP0002210_abnormal_sex_determination	3.35397793
8	MP0001929_abnormal_gametogenesis	3.28743345
9	MP0008058_abnormal_DNA_repair	3.23523485
10	MP0008995_early_reproductive_senescence	3.10160545
11	MP0003698_abnormal_male_reproductive	2.97169119
12	MP0003136_yellow_coat_color	2.87968061
13	MP0003693_abnormal_embryo_hatching	2.83454501
14	MP0001968_abnormal_touch/_nociception	2.78963191
15	MP0001145_abnormal_male_reproductive	2.55579996
16	MP0010094_abnormal_chromosome_stability	2.36840016
17	MP0003718_maternal_effect	2.36468756
18	MP0000653_abnormal_sex_gland	2.23618858
19	MP0005171_absent_coat_pigmentation	2.20671893
20	MP0003315_abnormal_perineum_morphology	2.12965236
21	MP0005389_reproductive_system_phenotype	2.12506120
22	MP0003111_abnormal_nucleus_morphology	2.04771930
23	MP0004957_abnormal_blastocyst_morpholog	2.02766459
24	MP0001529_abnormal_vocalization	1.98510592
25	MP0005174_abnormal_tail_pigmentation	1.96917145
26	MP0003077_abnormal_cell_cycle	1.95492337
27	MP0002736_abnormal_nociception_after	1.84767910
28	MP0002161_abnormal_fertility/fecundity	1.82975989
29	MP0003646_muscle_fatigue	1.77099442
30	MP0003283_abnormal_digestive_organ	1.75442061
31	MP0008789_abnormal_olfactory_epithelium	1.63400311
32	MP0008004_abnormal_stomach_pH	1.57850830
33	MP0005394_taste/olfaction_phenotype	1.49483203
34	MP0005499_abnormal_olfactory_system	1.49483203
35	MP0001119_abnormal_female_reproductive	1.47076726
36	MP0003699_abnormal_female_reproductive	1.45360732
37	MP0006035_abnormal_mitochondrial_morpho	1.44026843
38	MP0001661_extended_life_span	1.38140576
39	MP0003786_premature_aging	1.34880792
40	MP0008875_abnormal_xenobiotic_pharmacok	1.21265949
41	MP0003119_abnormal_digestive_system	1.14382374
42	MP0002735_abnormal_chemical_nociception	1.09792172
43	MP0001672_abnormal_embryogenesis/_devel	1.03324992
44	MP0005380_embryogenesis_phenotype	1.03324992
45	MP0006036_abnormal_mitochondrial_physio	1.02829630
46	MP0001664_abnormal_digestion	1.01477239
47	MP0004019_abnormal_vitamin_homeostasis	1.00610320
48	MP0009278_abnormal_bone_marrow	1.00545698
49	MP0004147_increased_porphyrin_level	0.99459457
50	MP0001919_abnormal_reproductive_system	0.98518138
51	MP0000538_abnormal_urinary_bladder	0.97869522
52	MP0000358_abnormal_cell_content/	0.96011531
53	MP0005386_behavior/neurological_phenoty	0.94925581
54	MP0004924_abnormal_behavior	0.94925581
55	MP0005647_abnormal_sex_gland	0.93249303
56	MP0008932_abnormal_embryonic_tissue	0.92856078
57	MP0005083_abnormal_biliary_tract	0.91749281
58	MP0005187_abnormal_penis_morphology	0.89529010
59	MP0000678_abnormal_parathyroid_gland	0.88576606
60	MP0001697_abnormal_embryo_size	0.86259193
61	MP0009046_muscle_twitch	0.84922974
62	MP0001188_hyperpigmentation	0.83664263
63	MP0005645_abnormal_hypothalamus_physiol	0.83603904
64	MP0001984_abnormal_olfaction	0.82916552
65	MP0005670_abnormal_white_adipose	0.82356865
66	MP0001346_abnormal_lacrimal_gland	0.81861261
67	MP0009379_abnormal_foot_pigmentation	0.81806421
68	MP0000470_abnormal_stomach_morphology	0.79958462
69	MP0003984_embryonic_growth_retardation	0.79836239
70	MP0002084_abnormal_developmental_patter	0.78836380
71	MP0005551_abnormal_eye_electrophysiolog	0.77038817
72	MP0001730_embryonic_growth_arrest	0.76629916
73	MP0001764_abnormal_homeostasis	0.75481594
74	MP0002088_abnormal_embryonic_growth/wei	0.75335036
75	MP0002085_abnormal_embryonic_tissue	0.74819258
76	MP0005253_abnormal_eye_physiology	0.74565981
77	MP0001502_abnormal_circadian_rhythm	0.74124404
78	MP0008007_abnormal_cellular_replicative	0.73757994
79	MP0000750_abnormal_muscle_regeneration	0.71006101
80	MP0003959_abnormal_lean_body	0.70278794
81	MP0002080_prenatal_lethality	0.69412654
82	MP0009333_abnormal_splenocyte_physiolog	0.68775206
83	MP0000313_abnormal_cell_death	0.64286139
84	MP0003936_abnormal_reproductive_system	0.64112035
85	MP0005330_cardiomyopathy	0.63299721
86	MP0000427_abnormal_hair_cycle	0.62850688
87	MP0004145_abnormal_muscle_electrophysio	0.61633641
88	MP0002557_abnormal_social/conspecific_i	0.60094812
89	MP0001485_abnormal_pinna_reflex	0.59483588
90	MP0003937_abnormal_limbs/digits/tail_de	0.58823893
91	MP0003806_abnormal_nucleotide_metabolis	0.56873244
92	MP0006292_abnormal_olfactory_placode	0.55549529
93	MP0000350_abnormal_cell_proliferation	0.54782870
94	MP0005332_abnormal_amino_acid	0.54698661
95	MP0002272_abnormal_nervous_system	0.54475835
96	MP0000647_abnormal_sebaceous_gland	0.49446134
97	MP0003861_abnormal_nervous_system	0.48931856
98	MP0005360_urolithiasis	0.48611618
99	MP0002086_abnormal_extraembryonic_tissu	0.47621420
100	MP0004215_abnormal_myocardial_fiber	0.47127363

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Birth length less than 3rd percentile (HP:0003561)	6.10067765
2	Attenuation of retinal blood vessels (HP:0007843)	4.91541460
3	Microretrognathia (HP:0000308)	4.40139039
4	Rectal fistula (HP:0100590)	4.06568393
5	Rectovaginal fistula (HP:0000143)	4.06568393
6	Facial hemangioma (HP:0000329)	3.84841027
7	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.80827571
8	Abnormality of alanine metabolism (HP:0010916)	3.80827571
9	Hyperalaninemia (HP:0003348)	3.80827571
10	Pendular nystagmus (HP:0012043)	3.68289499
11	Intestinal fistula (HP:0100819)	3.60326097
12	Bony spicule pigmentary retinopathy (HP:0007737)	3.59035599
13	Vaginal fistula (HP:0004320)	3.52834139
14	Patellar aplasia (HP:0006443)	3.46443977
15	Breast hypoplasia (HP:0003187)	3.36156202
16	Horizontal nystagmus (HP:0000666)	3.34172515
17	Testicular atrophy (HP:0000029)	3.26418033
18	Aplasia/Hypoplasia of the patella (HP:0006498)	3.16872803
19	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.09981071
20	Mesangial abnormality (HP:0001966)	3.00978613
21	Broad distal phalanx of finger (HP:0009836)	2.94540294
22	Rib fusion (HP:0000902)	2.93775128
23	Absent thumb (HP:0009777)	2.90553198
24	Azoospermia (HP:0000027)	2.88104863
25	Abnormal pancreas size (HP:0012094)	2.68740594
26	Abnormality of DNA repair (HP:0003254)	2.65782494
27	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.65371473
28	Hypoplasia of the uterus (HP:0000013)	2.64175699
29	Duplicated collecting system (HP:0000081)	2.63668609
30	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.63629194
31	Dyschromatopsia (HP:0007641)	2.63141329
32	Absent/shortened dynein arms (HP:0200106)	2.58866747
33	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.58866747
34	Absent radius (HP:0003974)	2.58435178
35	Abnormal glycosylation (HP:0012345)	2.57921201
36	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.57921201
37	Abnormal protein N-linked glycosylation (HP:0012347)	2.57921201
38	Abnormal protein glycosylation (HP:0012346)	2.57921201
39	Decreased central vision (HP:0007663)	2.54728312
40	Genetic anticipation (HP:0003743)	2.54173174
41	Infertility (HP:0000789)	2.51656547
42	Abnormal respiratory motile cilium physiology (HP:0012261)	2.45114122
43	Congenital stationary night blindness (HP:0007642)	2.44809333
44	Aplasia involving forearm bones (HP:0009822)	2.43714602
45	Absent forearm bone (HP:0003953)	2.43714602
46	Chromsome breakage (HP:0040012)	2.39309956
47	Microvesicular hepatic steatosis (HP:0001414)	2.38908448
48	Abnormality of the renal collecting system (HP:0004742)	2.36565141
49	Abnormality of cochlea (HP:0000375)	2.30992533
50	Male infertility (HP:0003251)	2.29302215
51	Capillary hemangiomas (HP:0005306)	2.28133442
52	Squamous cell carcinoma (HP:0002860)	2.24786291
53	Dysdiadochokinesis (HP:0002075)	2.23438539
54	Poikiloderma (HP:0001029)	2.22673172
55	Aplasia/hypoplasia of the uterus (HP:0008684)	2.21465509
56	Ectopic kidney (HP:0000086)	2.21458392
57	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.19313167
58	Optic disc pallor (HP:0000543)	2.19299296
59	Chorioretinal atrophy (HP:0000533)	2.15477796
60	Abnormality of the intrinsic pathway (HP:0010989)	2.13721047
61	Spontaneous abortion (HP:0005268)	2.13284906
62	Lipid accumulation in hepatocytes (HP:0006561)	2.08837479
63	Hypoalbuminemia (HP:0003073)	2.08047644
64	Abnormal albumin level (HP:0012116)	2.08047644
65	Prolonged partial thromboplastin time (HP:0003645)	2.05405168
66	Abnormal spermatogenesis (HP:0008669)	2.05312471
67	Meckel diverticulum (HP:0002245)	2.04833393
68	Concave nail (HP:0001598)	2.00641582
69	Abnormality of the ileum (HP:0001549)	2.00466550
70	Abnormality of the preputium (HP:0100587)	1.97565784
71	Reticulocytopenia (HP:0001896)	1.96782173
72	Morphological abnormality of the inner ear (HP:0011390)	1.93741150
73	Abnormal ciliary motility (HP:0012262)	1.93389949
74	Esotropia (HP:0000565)	1.93265715
75	Short thumb (HP:0009778)	1.92591256
76	Abnormality of the columella (HP:0009929)	1.91327410
77	Dysmetric saccades (HP:0000641)	1.86606876
78	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.86150479
79	Increased hepatocellular lipid droplets (HP:0006565)	1.83378424
80	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.81645957
81	Premature ovarian failure (HP:0008209)	1.80663532
82	Tubulointerstitial nephritis (HP:0001970)	1.79959988
83	Rectal prolapse (HP:0002035)	1.78333173
84	Hypoplasia of the radius (HP:0002984)	1.78210066
85	Retinal dysplasia (HP:0007973)	1.77939715
86	Ureteral duplication (HP:0000073)	1.77938267
87	Small intestinal stenosis (HP:0012848)	1.77635404
88	Duodenal stenosis (HP:0100867)	1.77635404
89	Postural instability (HP:0002172)	1.77625915
90	Patent foramen ovale (HP:0001655)	1.77074100
91	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.76185238
92	Flat occiput (HP:0005469)	1.72166664
93	Thin ribs (HP:0000883)	1.68398292
94	Delayed epiphyseal ossification (HP:0002663)	1.68071435
95	Anteriorly placed anus (HP:0001545)	1.67706188
96	Hypoplasia of the pons (HP:0012110)	1.67620912
97	Macular degeneration (HP:0000608)	1.66661567
98	Oligodactyly (hands) (HP:0001180)	1.66246297
99	Non-midline cleft lip (HP:0100335)	1.63653856
100	Abnormal sex determination (HP:0012244)	1.62888894

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	4.47931105
2	ADRBK2	3.92583274
3	WNK4	3.91772655
4	MAPK15	3.30457963
5	NEK2	2.87785228
6	BMPR1B	2.85533913
7	BMX	2.71559880
8	TTK	2.35145544
9	BUB1	2.27836729
10	INSRR	2.27547106
11	ZAK	2.25521122
12	MARK3	2.19123877
13	PDK2	2.14125617
14	PNCK	2.02065982
15	PLK4	1.98349328
16	ACVR1B	1.92187744
17	MELK	1.86461260
18	PBK	1.84784564
19	WEE1	1.74324886
20	ICK	1.71394915
21	DYRK3	1.68454570
22	TLK1	1.66012307
23	CDK19	1.64220888
24	PLK1	1.60202278
25	MUSK	1.58100893
26	TGFBR1	1.58090031
27	KSR2	1.51725314
28	CDC7	1.36564324
29	STK16	1.28520991
30	SRPK1	1.27675688
31	WNK1	1.21571820
32	MET	1.17156820
33	RPS6KA5	1.12409026
34	BRAF	1.12361761
35	MAP2K2	1.11037341
36	OXSR1	1.09315684
37	ADRBK1	1.06788489
38	AURKA	1.02642662
39	PASK	0.98384067
40	CDK8	0.97024973
41	CCNB1	0.96568214
42	CHEK2	0.96551500
43	ATR	0.96464950
44	SMG1	0.95809574
45	VRK2	0.94937929
46	VRK1	0.94645657
47	CHEK1	0.92480554
48	PDPK1	0.79505083
49	BRSK2	0.74601776
50	CDK7	0.72528035
51	BRD4	0.72415620
52	TSSK6	0.72323478
53	BRSK1	0.69221589
54	MAP3K2	0.68816821
55	MST1R	0.67811822
56	AURKB	0.65331135
57	STK3	0.64681898
58	CDK14	0.64224953
59	STK38L	0.64195112
60	CDK1	0.63189476
61	RAF1	0.62795883
62	MAP2K1	0.62074496
63	NEK1	0.61568709
64	DAPK2	0.60217798
65	TYRO3	0.58172780
66	NUAK1	0.57626858
67	DYRK2	0.57422741
68	ATM	0.57014274
69	FGR	0.56939071
70	NME1	0.56667974
71	CDK3	0.56482655
72	TAF1	0.54947671
73	CDK11A	0.53860133
74	PAK1	0.52941951
75	CSNK1E	0.52684043
76	STK11	0.50931226
77	CDK4	0.50827285
78	MAP3K8	0.50340056
79	TESK2	0.49890526
80	CDK2	0.49323243
81	CDK15	0.48397553
82	ARAF	0.47029216
83	EIF2AK3	0.46801772
84	PRKCG	0.46779422
85	MAP2K6	0.45776255
86	AKT2	0.45417646
87	GRK1	0.42818635
88	MAP3K10	0.41911329
89	STK38	0.41807298
90	CDK18	0.40974883
91	PTK2B	0.38825101
92	CSF1R	0.38497338
93	CSNK2A1	0.37780777
94	RPS6KA6	0.36464093
95	STK4	0.31505510
96	PLK3	0.30882655
97	STK39	0.29927410
98	RPS6KB1	0.28966499
99	LATS2	0.27856743
100	CSNK2A2	0.27228483

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.38518837
2	Homologous recombination_Homo sapiens_hsa03440	3.35392136
3	Sulfur relay system_Homo sapiens_hsa04122	3.28079079
4	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.07095882
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.06073437
6	One carbon pool by folate_Homo sapiens_hsa00670	2.82527903
7	DNA replication_Homo sapiens_hsa03030	2.63857972
8	Basal transcription factors_Homo sapiens_hsa03022	2.61935813
9	Cell cycle_Homo sapiens_hsa04110	2.51350191
10	RNA transport_Homo sapiens_hsa03013	2.33700683
11	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.32584348
12	RNA polymerase_Homo sapiens_hsa03020	2.31243764
13	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.30193475
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.21420030
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.98619557
16	Base excision repair_Homo sapiens_hsa03410	1.88483767
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.88086391
18	Taste transduction_Homo sapiens_hsa04742	1.86326709
19	Folate biosynthesis_Homo sapiens_hsa00790	1.84174709
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.75619333
21	Ribosome_Homo sapiens_hsa03010	1.69522449
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.68459561
23	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.68036630
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.64996973
25	Mismatch repair_Homo sapiens_hsa03430	1.58852412
26	Oocyte meiosis_Homo sapiens_hsa04114	1.56153761
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.49908320
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.43166811
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.40880964
30	Regulation of autophagy_Homo sapiens_hsa04140	1.39574395
31	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.38971684
32	Propanoate metabolism_Homo sapiens_hsa00640	1.38263825
33	Gap junction_Homo sapiens_hsa04540	1.36549522
34	Pyruvate metabolism_Homo sapiens_hsa00620	1.36442920
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.32564521
36	mRNA surveillance pathway_Homo sapiens_hsa03015	1.23210720
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.23082731
38	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.18680669
39	RNA degradation_Homo sapiens_hsa03018	1.15191241
40	Spliceosome_Homo sapiens_hsa03040	1.14730012
41	Huntingtons disease_Homo sapiens_hsa05016	1.08760965
42	Parkinsons disease_Homo sapiens_hsa05012	1.06152002
43	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.05166306
44	Olfactory transduction_Homo sapiens_hsa04740	1.04033460
45	Non-homologous end-joining_Homo sapiens_hsa03450	1.00195587
46	Purine metabolism_Homo sapiens_hsa00230	0.96682235
47	Butanoate metabolism_Homo sapiens_hsa00650	0.96088881
48	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.93888831
49	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.93361822
50	Nicotine addiction_Homo sapiens_hsa05033	0.83470010
51	Calcium signaling pathway_Homo sapiens_hsa04020	0.81192482
52	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.76917474
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.76550105
54	Arginine biosynthesis_Homo sapiens_hsa00220	0.75821505
55	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.74175884
56	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.74115338
57	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.69333689
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.66085071
59	p53 signaling pathway_Homo sapiens_hsa04115	0.63274239
60	ABC transporters_Homo sapiens_hsa02010	0.60123571
61	Metabolic pathways_Homo sapiens_hsa01100	0.59082766
62	Apoptosis_Homo sapiens_hsa04210	0.54950967
63	Retinol metabolism_Homo sapiens_hsa00830	0.53562101
64	Oxidative phosphorylation_Homo sapiens_hsa00190	0.50107460
65	Circadian rhythm_Homo sapiens_hsa04710	0.50077040
66	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.48353040
67	Proteasome_Homo sapiens_hsa03050	0.46511345
68	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.45643049
69	Glutathione metabolism_Homo sapiens_hsa00480	0.44930954
70	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.43519150
71	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.40930021
72	Basal cell carcinoma_Homo sapiens_hsa05217	0.40032904
73	Phototransduction_Homo sapiens_hsa04744	0.39901572
74	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.38190339
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37883767
76	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.37752897
77	Alcoholism_Homo sapiens_hsa05034	0.34937672
78	Glutamatergic synapse_Homo sapiens_hsa04724	0.33776218
79	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.33350252
80	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.32682580
81	FoxO signaling pathway_Homo sapiens_hsa04068	0.32508468
82	Linoleic acid metabolism_Homo sapiens_hsa00591	0.32274097
83	Hippo signaling pathway_Homo sapiens_hsa04390	0.31954271
84	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.31911161
85	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.31825383
86	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.31151315
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.30911147
88	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.30736410
89	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.28775268
90	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.28012058
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.27628020
92	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.27049189
93	mTOR signaling pathway_Homo sapiens_hsa04150	0.26557291
94	Phenylalanine metabolism_Homo sapiens_hsa00360	0.25707881
95	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.25003636
96	Peroxisome_Homo sapiens_hsa04146	0.24754187
97	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.24740113
98	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.23852578
99	Sphingolipid metabolism_Homo sapiens_hsa00600	0.23575074
100	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.21096233

BHMG1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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