BHMT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)8.49445813
2omega-hydroxylase P450 pathway (GO:0097267)8.19604001
3L-phenylalanine catabolic process (GO:0006559)7.73672467
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.73672467
5L-phenylalanine metabolic process (GO:0006558)7.41457782
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.41457782
7aromatic amino acid family catabolic process (GO:0009074)6.96353227
8drug metabolic process (GO:0017144)6.46733137
9oxidative demethylation (GO:0070989)6.30899651
10tryptophan catabolic process (GO:0006569)6.23798700
11indole-containing compound catabolic process (GO:0042436)6.23798700
12indolalkylamine catabolic process (GO:0046218)6.23798700
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.21873227
14urea metabolic process (GO:0019627)6.16481107
15urea cycle (GO:0000050)6.16481107
16kynurenine metabolic process (GO:0070189)6.09502990
17bile acid biosynthetic process (GO:0006699)5.98009812
18tryptophan metabolic process (GO:0006568)5.87648541
19glyoxylate metabolic process (GO:0046487)5.86217791
20serine family amino acid catabolic process (GO:0009071)5.82450431
21cysteine metabolic process (GO:0006534)5.77880479
22response to mercury ion (GO:0046689)5.73134842
23nitrogen cycle metabolic process (GO:0071941)5.68704517
24sulfur amino acid catabolic process (GO:0000098)5.66514101
25phenylpropanoid metabolic process (GO:0009698)5.63795490
26negative regulation of fibrinolysis (GO:0051918)5.49714915
27alpha-linolenic acid metabolic process (GO:0036109)5.42774742
28high-density lipoprotein particle remodeling (GO:0034375)5.41029329
29homocysteine metabolic process (GO:0050667)5.37823117
30ethanol metabolic process (GO:0006067)5.35207689
31regulation of fibrinolysis (GO:0051917)5.25634470
32regulation of protein activation cascade (GO:2000257)5.23674176
33aromatic amino acid family metabolic process (GO:0009072)5.22681383
34complement activation, alternative pathway (GO:0006957)5.14887618
35protein carboxylation (GO:0018214)5.14255254
36peptidyl-glutamic acid carboxylation (GO:0017187)5.14255254
37glycine metabolic process (GO:0006544)5.13793031
38regulation of plasminogen activation (GO:0010755)5.10340668
39bile acid metabolic process (GO:0008206)5.08895018
40tyrosine metabolic process (GO:0006570)5.01042142
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.95835452
42alpha-amino acid catabolic process (GO:1901606)4.90418589
43regulation of complement activation (GO:0030449)4.89053895
44regulation of cholesterol esterification (GO:0010872)4.85845014
45regulation of triglyceride catabolic process (GO:0010896)4.83615918
46negative regulation of hemostasis (GO:1900047)4.81231871
47negative regulation of blood coagulation (GO:0030195)4.81231871
48serine family amino acid metabolic process (GO:0009069)4.76187169
49alkaloid metabolic process (GO:0009820)4.73862229
50* amino-acid betaine metabolic process (GO:0006577)4.70830398
51reverse cholesterol transport (GO:0043691)4.70425898
52lysine metabolic process (GO:0006553)4.69612300
53lysine catabolic process (GO:0006554)4.69612300
54protein-lipid complex remodeling (GO:0034368)4.69602930
55macromolecular complex remodeling (GO:0034367)4.69602930
56plasma lipoprotein particle remodeling (GO:0034369)4.69602930
57serine family amino acid biosynthetic process (GO:0009070)4.68118292
58cellular amino acid catabolic process (GO:0009063)4.52708112
59acylglycerol homeostasis (GO:0055090)4.49810096
60triglyceride homeostasis (GO:0070328)4.49810096
61* S-adenosylmethionine metabolic process (GO:0046500)4.49580025
62imidazole-containing compound metabolic process (GO:0052803)4.49449640
63phospholipid efflux (GO:0033700)4.46688695
64fat-soluble vitamin biosynthetic process (GO:0042362)4.46119659
65negative regulation of cholesterol transport (GO:0032375)4.44701160
66negative regulation of sterol transport (GO:0032372)4.44701160
67indolalkylamine metabolic process (GO:0006586)4.40824267
68cellular ketone body metabolic process (GO:0046950)4.38104153
69negative regulation of coagulation (GO:0050819)4.37274060
70amine catabolic process (GO:0009310)4.35612305
71cellular biogenic amine catabolic process (GO:0042402)4.35612305
72bile acid and bile salt transport (GO:0015721)4.32539992
73arginine metabolic process (GO:0006525)4.30869903
74negative regulation of wound healing (GO:0061045)4.29711002
75glutamate metabolic process (GO:0006536)4.29216760
76plasma lipoprotein particle clearance (GO:0034381)4.27215591
77coenzyme catabolic process (GO:0009109)4.26963076
78flavonoid metabolic process (GO:0009812)4.19039332
79aminoglycoside antibiotic metabolic process (GO:0030647)4.10072027
80cholesterol efflux (GO:0033344)4.09890043
81cellular modified amino acid catabolic process (GO:0042219)4.07024233
82cellular glucuronidation (GO:0052695)4.05223434
83benzene-containing compound metabolic process (GO:0042537)4.04822232
84dicarboxylic acid biosynthetic process (GO:0043650)4.00239894
85acute-phase response (GO:0006953)3.97447736
86low-density lipoprotein particle remodeling (GO:0034374)3.97192388
87intestinal cholesterol absorption (GO:0030299)3.96922537
88aldehyde catabolic process (GO:0046185)3.96062152
89positive regulation of hemostasis (GO:1900048)3.94749490
90positive regulation of blood coagulation (GO:0030194)3.94749490
91regulation of humoral immune response (GO:0002920)3.93876619
92carboxylic acid catabolic process (GO:0046395)3.91838279
93organic acid catabolic process (GO:0016054)3.91838279
94plasma lipoprotein particle assembly (GO:0034377)3.91651926
95negative regulation of protein activation cascade (GO:2000258)3.89428866
96ethanol oxidation (GO:0006069)3.88421769
97fibrinolysis (GO:0042730)3.85849075
98sodium-independent organic anion transport (GO:0043252)3.84590930
99positive regulation of lipoprotein lipase activity (GO:0051006)3.82007922
100positive regulation of triglyceride lipase activity (GO:0061365)3.82007922
101blood coagulation, intrinsic pathway (GO:0007597)3.81523801
102ketone body metabolic process (GO:1902224)3.78540021
103xenobiotic metabolic process (GO:0006805)3.77983376
104regulation of bile acid biosynthetic process (GO:0070857)3.74032382
105L-serine metabolic process (GO:0006563)3.72745927
106very-low-density lipoprotein particle assembly (GO:0034379)3.72120923
107acetyl-CoA metabolic process (GO:0006084)3.69737429
108cholesterol homeostasis (GO:0042632)3.69637286
109hormone catabolic process (GO:0042447)3.68538757
110polyketide metabolic process (GO:0030638)3.68422669
111doxorubicin metabolic process (GO:0044598)3.68422669
112daunorubicin metabolic process (GO:0044597)3.68422669
113heme transport (GO:0015886)3.67930339
114phospholipid homeostasis (GO:0055091)3.67771349
115drug catabolic process (GO:0042737)3.67070653
116killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.64905101
117disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.64905101
118positive regulation of lipid catabolic process (GO:0050996)3.63874586
119cofactor catabolic process (GO:0051187)3.63721677
120positive regulation of coagulation (GO:0050820)3.63639928
121drug transmembrane transport (GO:0006855)3.63292656
122sterol homeostasis (GO:0055092)3.63069341
123negative regulation of lipase activity (GO:0060192)3.62675370
124complement activation, classical pathway (GO:0006958)3.62278985
125regulation of cholesterol homeostasis (GO:2000188)3.60445988
126steroid catabolic process (GO:0006706)3.60270083
127NAD biosynthetic process (GO:0009435)3.59596866
128complement activation (GO:0006956)3.58842432
129uronic acid metabolic process (GO:0006063)3.56263416
130glucuronate metabolic process (GO:0019585)3.56263416
131primary alcohol catabolic process (GO:0034310)3.56080094
132protein activation cascade (GO:0072376)3.55994807
133nicotinamide nucleotide biosynthetic process (GO:0019359)3.55658794
134pyridine nucleotide biosynthetic process (GO:0019363)3.55658794
135cytolysis (GO:0019835)3.55169107
1362-oxoglutarate metabolic process (GO:0006103)3.55043286
137exogenous drug catabolic process (GO:0042738)10.1700885

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.32500525
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.19165286
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.94321368
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.31705500
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.39208670
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.33812125
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.83267364
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.24862139
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.86274627
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.17769667
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06293090
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02192046
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0114141
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90988424
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70447838
16HTT_18923047_ChIP-ChIP_STHdh_Human1.53279172
17CLOCK_20551151_ChIP-Seq_293T_Human1.52576646
18GATA1_22025678_ChIP-Seq_K562_Human1.45507130
19ESR1_20079471_ChIP-ChIP_T-47D_Human1.44132796
20FOXA2_19822575_ChIP-Seq_HepG2_Human1.40952882
21* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40779985
22ZNF263_19887448_ChIP-Seq_K562_Human1.31514644
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30901615
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.27401460
25* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20378851
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10277884
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04464846
28KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03555224
29SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02615741
30HNFA_21074721_ChIP-Seq_CACO-2_Human1.02342762
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.00848358
32PHF8_20622853_ChIP-Seq_HELA_Human1.00582925
33CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00537887
34BCAT_22108803_ChIP-Seq_LS180_Human1.00426053
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99827644
36PIAS1_25552417_ChIP-Seq_VCAP_Human0.99113598
37SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97753041
38NFE2_27457419_Chip-Seq_LIVER_Mouse0.97045088
39ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96055987
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95071197
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91709196
42NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90959066
43STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90438239
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89759682
45RARA_24833708_ChIP-Seq_LIVER_Mouse0.89226628
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88686559
47NFYA_21822215_ChIP-Seq_K562_Human0.87415288
48SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86581588
49EZH2_27294783_Chip-Seq_NPCs_Mouse0.86548488
50AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84342332
51GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83844109
52POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83555449
53TP53_18474530_ChIP-ChIP_U2OS_Human0.80285089
54GATA4_25053715_ChIP-Seq_YYC3_Human0.79418444
55RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78169135
56GATA6_21074721_ChIP-Seq_CACO-2_Human0.77979933
57SOX2_21211035_ChIP-Seq_LN229_Human0.77558864
58CDX2_20551321_ChIP-Seq_CACO-2_Human0.76103323
59RARB_24833708_ChIP-Seq_LIVER_Mouse0.75308502
60ER_23166858_ChIP-Seq_MCF-7_Human0.75252823
61CBX2_22325352_ChIP-Seq_293T-Rex_Human0.74457813
62PCGF2_27294783_Chip-Seq_NPCs_Mouse0.74397519
63CRX_20693478_ChIP-Seq_RETINA_Mouse0.73682490
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.73071313
65SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72124206
66ETV1_20927104_ChIP-Seq_GIST48_Human0.72084894
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72033944
68SUZ12_27294783_Chip-Seq_NPCs_Mouse0.71889815
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.71838320
70SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.71558249
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.71249567
72ETV2_25802403_ChIP-Seq_MESCs_Mouse0.70205539
73CDX2_22108803_ChIP-Seq_LS180_Human0.69869386
74OCT4_18555785_Chip-Seq_ESCs_Mouse0.68627573
75KLF5_20875108_ChIP-Seq_MESCs_Mouse0.68204529
76RAC3_21632823_ChIP-Seq_H3396_Human0.68131663
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.67236003
78BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66802678
79ESR2_21235772_ChIP-Seq_MCF-7_Human0.64430962
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.64350126
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.64348396
82CBP_20019798_ChIP-Seq_JUKART_Human0.64348396
83IGF1R_20145208_ChIP-Seq_DFB_Human0.64285401
84MYC_19829295_ChIP-Seq_ESCs_Human0.64189309
85NFYB_21822215_ChIP-Seq_K562_Human0.64165704
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.63530558
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63321446
88TCF4_22108803_ChIP-Seq_LS180_Human0.63003300
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.62966484
90PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.62545291
91ERG_20517297_ChIP-Seq_VCAP_Human0.61617741
92AR_21909140_ChIP-Seq_LNCAP_Human0.61569651
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.61341814
94OCT4_21477851_ChIP-Seq_ESCs_Mouse0.61274780
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.60979130
96ESRRB_18555785_Chip-Seq_ESCs_Mouse0.60663631
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.60591504
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.59830097
99TCF4_18268006_ChIP-ChIP_LS174T_Human0.59763290
100RUNX1_27457419_Chip-Seq_LIVER_Mouse0.58581969
101FOXA1_21572438_ChIP-Seq_LNCaP_Human0.58442579
102RBPJ_21746931_ChIP-Seq_IB4_Human0.58302962
103KLF4_18555785_Chip-Seq_ESCs_Mouse0.56895523
104SMAD1_18555785_Chip-Seq_ESCs_Mouse0.56839780
105* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56821986
106* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.56778167
107CEBPB_22108803_ChIP-Seq_LS180_Human0.55614567
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.54049617
109PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.53216132
110CREB1_15753290_ChIP-ChIP_HEK293T_Human0.51509617
111FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49405869
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.49287384
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.49133280
114PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48957344
115IRF8_22096565_ChIP-ChIP_GC-B_Human0.48086030
116MYC_19915707_ChIP-ChIP_AK7_Human0.48079676
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.47879377
118* TAF2_19829295_ChIP-Seq_ESCs_Human0.47804751
119AR_20517297_ChIP-Seq_VCAP_Human0.47730696
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.47006596
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.46196563
122* P53_21459846_ChIP-Seq_SAOS-2_Human0.46048671
123JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.44002285
124ESET_19884257_ChIP-Seq_ESCs_Mouse0.43986560
125OCT4_18692474_ChIP-Seq_MEFs_Mouse0.43859268
126CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.43824161
127FOXA1_25552417_ChIP-Seq_VCAP_Human0.43557243
128TET1_21451524_ChIP-Seq_MESCs_Mouse0.43092363
129NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.42531773
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.42382324
131SRF_21415370_ChIP-Seq_HL-1_Mouse0.41909751
132STAT1_17558387_ChIP-Seq_HELA_Human0.41861469
133BCOR_27268052_Chip-Seq_Bcells_Human0.41576040
134IRF1_19129219_ChIP-ChIP_H3396_Human0.41527788
135SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.41414107
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41385950
137GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.41120130
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.41082381
139EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.40868591
140ESR1_21235772_ChIP-Seq_MCF-7_Human0.40047507
141SPI1_26923725_Chip-Seq_HPCs_Mouse0.39671096
142FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39229282
143EGR1_19032775_ChIP-ChIP_M12_Human0.39111701
144KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.38622044
145GATA6_25053715_ChIP-Seq_YYC3_Human0.38367689
146LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.38001988
147CBP_21632823_ChIP-Seq_H3396_Human0.37758195
148SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.36569123
149FOXH1_21741376_ChIP-Seq_EPCs_Human0.36488029
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.36164315
151STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36058724
152SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.35676091
153LXR_22292898_ChIP-Seq_THP-1_Human0.35071563
154NANOG_16518401_ChIP-PET_MESCs_Mouse0.34108477
155NCOR_22424771_ChIP-Seq_293T_Human0.34096791
156SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33938819

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.00967196
2MP0005360_urolithiasis7.42631736
3MP0005085_abnormal_gallbladder_physiolo6.44418451
4MP0005365_abnormal_bile_salt6.27265355
5MP0008875_abnormal_xenobiotic_pharmacok4.92875101
6MP0003806_abnormal_nucleotide_metabolis4.46865558
7MP0003252_abnormal_bile_duct3.81257975
8MP0009840_abnormal_foam_cell3.73726184
9MP0010329_abnormal_lipoprotein_level3.58208612
10MP0005332_abnormal_amino_acid3.05631823
11MP0005083_abnormal_biliary_tract2.88447357
12MP0003195_calcinosis2.85162190
13MP0001666_abnormal_nutrient_absorption2.56277090
14MP0003191_abnormal_cellular_cholesterol2.34032428
15MP0004019_abnormal_vitamin_homeostasis2.33891903
16MP0000609_abnormal_liver_physiology2.21876555
17MP0002118_abnormal_lipid_homeostasis2.09388636
18MP0002138_abnormal_hepatobiliary_system2.02889788
19MP0005451_abnormal_body_composition1.90683846
20MP0005319_abnormal_enzyme/_coenzyme1.90401554
21MP0003868_abnormal_feces_composition1.90263894
22MP0001764_abnormal_homeostasis1.88794212
23MP0004043_abnormal_pH_regulation1.86029522
24MP0009697_abnormal_copulation1.62629172
25MP0005584_abnormal_enzyme/coenzyme_acti1.52591719
26MP0003186_abnormal_redox_activity1.43041194
27MP0003011_delayed_dark_adaptation1.33146055
28MP0009643_abnormal_urine_homeostasis1.29666194
29MP0003656_abnormal_erythrocyte_physiolo1.29513725
30MP0000598_abnormal_liver_morphology1.23151529
31MP0000604_amyloidosis1.11237157
32MP0003705_abnormal_hypodermis_morpholog1.06911408
33MP0003718_maternal_effect1.06322175
34MP0005647_abnormal_sex_gland1.04036153
35MP0005670_abnormal_white_adipose1.00621212
36MP0009764_decreased_sensitivity_to0.98079421
37MP0001661_extended_life_span0.97977641
38MP0009763_increased_sensitivity_to0.96950467
39MP0005636_abnormal_mineral_homeostasis0.93281977
40MP0006036_abnormal_mitochondrial_physio0.91757923
41MP0002254_reproductive_system_inflammat0.91432996
42MP0005408_hypopigmentation0.89877640
43MP0008469_abnormal_protein_level0.88483673
44MP0009642_abnormal_blood_homeostasis0.86907495
45MP0002876_abnormal_thyroid_physiology0.84430615
46MP0005376_homeostasis/metabolism_phenot0.83140139
47MP0003879_abnormal_hair_cell0.80008567
48MP0010368_abnormal_lymphatic_system0.77812364
49MP0003329_amyloid_beta_deposits0.77108555
50MP0001756_abnormal_urination0.77040307
51MP0006035_abnormal_mitochondrial_morpho0.76107776
52MP0009765_abnormal_xenobiotic_induced0.74576107
53MP0005084_abnormal_gallbladder_morpholo0.73270685
54MP0005395_other_phenotype0.72910409
55MP0009053_abnormal_anal_canal0.72674667
56MP0002078_abnormal_glucose_homeostasis0.71812420
57MP0005266_abnormal_metabolism0.66950292
58MP0005220_abnormal_exocrine_pancreas0.66465299
59MP0002971_abnormal_brown_adipose0.65876644
60MP0005334_abnormal_fat_pad0.65100843
61MP0002282_abnormal_trachea_morphology0.63813422
62MP0005187_abnormal_penis_morphology0.63788331
63MP0001915_intracranial_hemorrhage0.63731375
64MP0003690_abnormal_glial_cell0.60892540
65MP0005535_abnormal_body_temperature0.60524245
66MP0004130_abnormal_muscle_cell0.58835279
67MP0000639_abnormal_adrenal_gland0.51960083
68MP0008260_abnormal_autophagy0.51498252
69MP0004381_abnormal_hair_follicle0.50858456
70MP0009672_abnormal_birth_weight0.49932661
71MP0002136_abnormal_kidney_physiology0.47946685
72MP0005448_abnormal_energy_balance0.46149982
73MP0008873_increased_physiological_sensi0.46099538
74MP0003638_abnormal_response/metabolism_0.44074575
75MP0005464_abnormal_platelet_physiology0.44036898
76MP0002249_abnormal_larynx_morphology0.42367078
77MP0005058_abnormal_lysosome_morphology0.40966089
78MP0001765_abnormal_ion_homeostasis0.39291467
79MP0003953_abnormal_hormone_level0.38773242
80MP0004782_abnormal_surfactant_physiolog0.37938555
81MP0005666_abnormal_adipose_tissue0.37918773
82MP0008961_abnormal_basal_metabolism0.37041207
83MP0001853_heart_inflammation0.36560244
84MP0003959_abnormal_lean_body0.35909652
85MP0002822_catalepsy0.35456197
86MP0000230_abnormal_systemic_arterial0.34300146
87MP0002796_impaired_skin_barrier0.34228564
88MP0008874_decreased_physiological_sensi0.32542789
89MP0009785_altered_susceptibility_to0.32031025
90MP0009115_abnormal_fat_cell0.31382858
91MP0002168_other_aberrant_phenotype0.31320602
92MP0005248_abnormal_Harderian_gland0.30867144
93MP0002837_dystrophic_cardiac_calcinosis0.30556648
94MP0005023_abnormal_wound_healing0.30297094
95MP0002970_abnormal_white_adipose0.29563722
96MP0001243_abnormal_dermal_layer0.29339758
97MP0000579_abnormal_nail_morphology0.29267516
98MP0008872_abnormal_physiological_respon0.29042801
99MP0002269_muscular_atrophy0.28983811
100MP0001542_abnormal_bone_strength0.28760362
101MP0003724_increased_susceptibility_to0.28147249
102MP0002928_abnormal_bile_duct0.27965116
103MP0001881_abnormal_mammary_gland0.27881864
104MP0003436_decreased_susceptibility_to0.27495022
105MP0010386_abnormal_urinary_bladder0.27429572
106MP0002132_abnormal_respiratory_system0.27352995
107MP0000467_abnormal_esophagus_morphology0.27197083
108MP0004883_abnormal_blood_vessel0.27022406
109MP0003699_abnormal_female_reproductive0.26746859
110MP0004142_abnormal_muscle_tone0.26731434
111MP0005166_decreased_susceptibility_to0.26512235
112MP0000249_abnormal_blood_vessel0.25858917
113MP0002135_abnormal_kidney_morphology0.24987799
114MP0003878_abnormal_ear_physiology0.24966316
115MP0005377_hearing/vestibular/ear_phenot0.24966316
116MP0001845_abnormal_inflammatory_respons0.24950795
117MP0003075_altered_response_to0.24192460
118MP0005164_abnormal_response_to0.23067851
119MP0002069_abnormal_eating/drinking_beha0.22536496
120MP0001944_abnormal_pancreas_morphology0.21705162
121MP0000566_synostosis0.21369438
122MP0001851_eye_inflammation0.20417455
123MP0005197_abnormal_uvea_morphology0.18100084
124MP0002332_abnormal_exercise_endurance0.15912666
125MP0003300_gastrointestinal_ulcer0.15830386

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.45249104
2Intrahepatic cholestasis (HP:0001406)7.06909794
3Abnormality of monocarboxylic acid metabolism (HP:0010996)7.05923110
4Deep venous thrombosis (HP:0002625)6.98112071
5Hypobetalipoproteinemia (HP:0003563)6.55323481
6Xanthomatosis (HP:0000991)6.34407390
7Prolonged partial thromboplastin time (HP:0003645)6.28837340
8Hyperlipoproteinemia (HP:0010980)5.68690305
9Hyperglycinemia (HP:0002154)5.11966503
10Complement deficiency (HP:0004431)5.02068299
11Hypolipoproteinemia (HP:0010981)4.89888380
12Hyperammonemia (HP:0001987)4.84204900
13Abnormality of methionine metabolism (HP:0010901)4.77344808
14Abnormality of sulfur amino acid metabolism (HP:0004339)4.62199236
15Hyperglycinuria (HP:0003108)4.55283536
16Epidermoid cyst (HP:0200040)4.49300274
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.49217025
18Joint hemorrhage (HP:0005261)4.48167810
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.46164566
20Abnormality of glycine metabolism (HP:0010895)4.41490753
21Abnormality of serine family amino acid metabolism (HP:0010894)4.41490753
22Abnormality of pyrimidine metabolism (HP:0004353)4.29927983
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.29475092
24Abnormality of the common coagulation pathway (HP:0010990)4.22951117
25Hypoalphalipoproteinemia (HP:0003233)4.22829532
26Ketosis (HP:0001946)4.08118439
27Fat malabsorption (HP:0002630)4.02280923
28Increased circulating renin level (HP:0000848)3.86096706
29Hypoglycemic coma (HP:0001325)3.81812918
30Abnormality of serum amino acid levels (HP:0003112)3.69826283
31Abnormality of complement system (HP:0005339)3.63804930
32Abnormality of the intrinsic pathway (HP:0010989)3.55130023
33Abnormality of fatty-acid metabolism (HP:0004359)3.52285459
34Hypercholesterolemia (HP:0003124)3.49621283
35Conjugated hyperbilirubinemia (HP:0002908)3.47131141
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.46005487
37Nephritis (HP:0000123)3.38990105
38Metabolic alkalosis (HP:0200114)3.28248048
39Abnormality of nucleobase metabolism (HP:0010932)3.25766523
40Hyperbilirubinemia (HP:0002904)3.17817054
41Hypokalemic alkalosis (HP:0001949)3.17427157
42Delayed CNS myelination (HP:0002188)3.10152486
43Hyperphosphaturia (HP:0003109)3.03080153
44Steatorrhea (HP:0002570)3.00406935
45Osteomalacia (HP:0002749)2.97608495
46Lethargy (HP:0001254)2.94165543
47Spontaneous abortion (HP:0005268)2.93582337
48Hyperactive renin-angiotensin system (HP:0000841)2.90555187
49Gout (HP:0001997)2.88212000
50Hepatocellular carcinoma (HP:0001402)2.82528766
51Myocardial infarction (HP:0001658)2.82140254
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.80561189
53Dicarboxylic aciduria (HP:0003215)2.80561189
54Skin nodule (HP:0200036)2.79647881
55Metabolic acidosis (HP:0001942)2.77882471
56Ketoacidosis (HP:0001993)2.73888230
57Abnormality of purine metabolism (HP:0004352)2.73685793
58Hypochromic microcytic anemia (HP:0004840)2.70768856
59Cerebral edema (HP:0002181)2.63571822
60Irritability (HP:0000737)2.61549308
61Spastic diplegia (HP:0001264)2.54800653
62Hypomagnesemia (HP:0002917)2.53831978
63Acanthocytosis (HP:0001927)2.48542785
64Fair hair (HP:0002286)2.47826441
65Systemic lupus erythematosus (HP:0002725)2.46082010
66Abnormal urine phosphate concentration (HP:0012599)2.42126074
67Vascular calcification (HP:0004934)2.41504380
68Neonatal onset (HP:0003623)2.35067550
69Malnutrition (HP:0004395)2.33790833
70Abnormal urine output (HP:0012590)2.32217887
71Glomerulonephritis (HP:0000099)2.29625885
72Brushfield spots (HP:0001088)2.24355169
73Polyuria (HP:0000103)2.22294978
74Mitral stenosis (HP:0001718)2.21360047
75Hypoglycemic seizures (HP:0002173)2.20635683
76Abnormality of chloride homeostasis (HP:0011422)2.18098435
77Abnormal gallbladder morphology (HP:0012437)2.16627340
78Reduced antithrombin III activity (HP:0001976)2.15533011
79Neonatal hypoglycemia (HP:0001998)2.14550222
80Cardiovascular calcification (HP:0011915)2.12331912
81Cholelithiasis (HP:0001081)2.11700008
82Purpura (HP:0000979)2.11588842
83Hypokalemia (HP:0002900)2.11381323
84Vomiting (HP:0002013)2.11106545
85Pancreatitis (HP:0001733)2.09730107
86Pulmonary embolism (HP:0002204)2.09087092
87Generalized aminoaciduria (HP:0002909)2.08123480
88Hyperaldosteronism (HP:0000859)2.07863304
89Abnormal cartilage morphology (HP:0002763)2.07268252
90Hypophosphatemic rickets (HP:0004912)2.06017462
91Esophageal varix (HP:0002040)2.05519413
92Sensorimotor neuropathy (HP:0007141)2.05135166
93Abnormality of magnesium homeostasis (HP:0004921)2.04600275
94Elevated alkaline phosphatase (HP:0003155)2.04555917
95Recurrent gram-negative bacterial infections (HP:0005420)2.03800049
96Arthropathy (HP:0003040)2.03459301
97Proximal tubulopathy (HP:0000114)2.02476776
98Abnormality of renal excretion (HP:0011036)2.02463467
99Amyloidosis (HP:0011034)2.02438070
100Gingival bleeding (HP:0000225)2.01060762
101Renal salt wasting (HP:0000127)1.98833870
102Alkalosis (HP:0001948)1.98545407
103Opisthotonus (HP:0002179)1.98519488
104Impaired platelet aggregation (HP:0003540)1.97970179
105Abnormal platelet function (HP:0011869)1.97970179
106Hyperglycemia (HP:0003074)1.97838125
107Abnormal enzyme/coenzyme activity (HP:0012379)1.96134416
108Increased purine levels (HP:0004368)1.94585888
109Hyperuricemia (HP:0002149)1.94585888
110Nausea (HP:0002018)1.94495879
111Cholecystitis (HP:0001082)1.92547834
112Abnormal gallbladder physiology (HP:0012438)1.92547834
113Thrombophlebitis (HP:0004418)1.92234218
114Enlarged kidneys (HP:0000105)1.90412555
115Poikilocytosis (HP:0004447)1.90092335
116Abnormality of alkaline phosphatase activity (HP:0004379)1.89591620
117Menorrhagia (HP:0000132)1.89496080
118Abnormality of transition element cation homeostasis (HP:0011030)1.89468312
119Renal cortical cysts (HP:0000803)1.89004019
120Abnormality of iron homeostasis (HP:0011031)1.86348627
121Late onset (HP:0003584)1.85141256
122Facial shape deformation (HP:0011334)1.81735921
123Potter facies (HP:0002009)1.81735921
124Hyperinsulinemic hypoglycemia (HP:0000825)1.81514906
125Abnormality of proline metabolism (HP:0010907)1.80797445
126Hydroxyprolinuria (HP:0003080)1.80797445
127Bifid scrotum (HP:0000048)1.80125055
128Spastic paraparesis (HP:0002313)1.79518121
129Hypophosphatemia (HP:0002148)1.78879748
130Bile duct proliferation (HP:0001408)1.78334975
131Abnormal biliary tract physiology (HP:0012439)1.78334975
132Elevated hepatic transaminases (HP:0002910)1.77088373
133Abnormality of vitamin metabolism (HP:0100508)1.76146309
134Hemorrhage of the eye (HP:0011885)1.75798129
135Rickets (HP:0002748)1.75073408
136Glycosuria (HP:0003076)1.74961794
137Abnormality of urine glucose concentration (HP:0011016)1.74961794

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.61656515
2OXSR16.24971718
3FGFR44.30309318
4SIK13.91492517
5ERN13.30582836
6ERBB42.60205694
7INSRR2.47409749
8TAOK32.43289481
9IRAK32.41415380
10WNK42.29059361
11AKT32.16737532
12MST1R2.14061285
13WNK310.5087602
14SGK4941.98355831
15SGK2231.98355831
16MAP2K41.93641544
17RIPK11.89439188
18ABL21.85249529
19EPHA21.83884722
20MAPK111.78717208
21PIK3CA1.77579387
22STK161.72890069
23PIK3CG1.67871798
24PINK11.62233145
25LATS11.49402923
26TYK21.46107917
27FLT31.45661542
28PKN21.44751646
29KDR1.44555639
30BUB11.43982408
31STK391.43689731
32BCR1.36559602
33NEK91.34061781
34NTRK31.33433296
35WEE11.33178179
36TRIB31.27172564
37STK38L1.24062012
38FRK1.18655488
39PDK31.14267913
40PDK41.14267913
41FGFR21.10194738
42DAPK21.07047498
43EIF2AK11.06772630
44TSSK61.00713036
45MAPK40.98667772
46PTK60.97670959
47JAK20.96923400
48ZAK0.96196043
49PLK40.93264842
50PRKAA20.92958954
51NEK10.92133579
52NLK0.91652048
53ERBB20.90950243
54PRKCZ0.89439622
55FGFR30.88654395
56MAP3K110.87172979
57MAP3K120.87046787
58MAP3K30.86936508
59CAMK2G0.84170437
60FER0.83972460
61GRK60.81732429
62IRAK20.79477422
63MYLK0.74450192
64MAP2K30.74045839
65PRKAA10.73949834
66PRKACA0.73537852
67TBK10.72534834
68CDK60.72446789
69CSNK1G10.71178345
70CDK40.70225176
71PRKACG0.70177032
72MET0.69773633
73MAPK120.68034659
74JAK10.66532186
75PRKG10.66191767
76SGK10.64842514
77MAP3K70.64610023
78PDK20.64513292
79PRKCG0.64165551
80TIE10.61460021
81TNK20.60888475
82EPHA40.60829813
83MAP4K20.60237939
84IRAK10.59995694
85TTK0.59914974
86LATS20.59839233
87MAP3K20.59183170
88MAP3K100.58753496
89MAPK70.58615477
90GSK3A0.56607970
91EPHA30.55457082
92CSNK1A10.54509350
93TESK20.52897184
94PNCK0.52783586
95CSNK1G30.52728130
96MAP2K60.51028133
97TAOK20.50566711
98CAMKK20.50211443
99PDPK10.50046115
100STK30.49197460
101GRK10.48187770
102PRKCB0.48159910
103ADRBK20.47790363
104PRKCA0.47182036
105MAP3K50.46401868
106SGK30.43147227
107DYRK1B0.43127134
108MTOR0.42910575
109MAPKAPK30.42776393
110EPHB10.42145116
111RPS6KA30.40864031
112CSNK1G20.40756341
113ACVR1B0.40692318
114MAP2K20.40588168
115MAPK150.40536351
116NUAK10.40529751
117RET0.40501858
118CSNK1D0.40472949
119BRSK20.40072329
120MAP2K10.37906973
121CSF1R0.37899355
122PBK0.35069248
123MAP3K140.34211131
124SRC0.34000311
125CSNK1E0.33912304
126CSNK1A1L0.33344716
127PRKCE0.31809072
128STK380.31577800
129NME20.29812612
130CSK0.29561881
131PTK20.29478032
132IGF1R0.27356786
133PDK10.27091971
134EIF2AK30.25791509
135BRAF0.24677039
136SGK20.24556665
137PAK30.24515892
138CASK0.23840159
139PRKACB0.23581021
140CHUK0.22154503
141MAP3K10.21145765
142PRPF4B0.21010088
143CSNK2A10.19307235
144PRKCD0.19148874
145TGFBR20.18849488
146MAP3K130.17161574
147CAMK40.13596057
148MAPK30.12617000

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.45008186
2Nitrogen metabolism_Homo sapiens_hsa009103.74650731
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.53626237
4Arginine biosynthesis_Homo sapiens_hsa002203.23390647
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.16196257
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.77264347
7* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.75723774
8Tryptophan metabolism_Homo sapiens_hsa003802.58140780
9Complement and coagulation cascades_Homo sapiens_hsa046102.56759467
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44230667
11Fatty acid degradation_Homo sapiens_hsa000712.42636257
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39059758
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16239634
14Butanoate metabolism_Homo sapiens_hsa006502.11467527
15Peroxisome_Homo sapiens_hsa041462.04689037
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95507504
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.90661666
18Propanoate metabolism_Homo sapiens_hsa006401.89390045
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.88975778
20Histidine metabolism_Homo sapiens_hsa003401.88123366
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.86605812
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.81080652
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.78314183
24Chemical carcinogenesis_Homo sapiens_hsa052041.78033891
25PPAR signaling pathway_Homo sapiens_hsa033201.77705501
26beta-Alanine metabolism_Homo sapiens_hsa004101.75635963
27Fatty acid metabolism_Homo sapiens_hsa012121.72595072
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66845222
29Selenocompound metabolism_Homo sapiens_hsa004501.66541169
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66527964
31Vitamin B6 metabolism_Homo sapiens_hsa007501.63095139
32Retinol metabolism_Homo sapiens_hsa008301.61476931
33Staphylococcus aureus infection_Homo sapiens_hsa051501.59633671
34Phenylalanine metabolism_Homo sapiens_hsa003601.59281612
35Caffeine metabolism_Homo sapiens_hsa002321.56842699
36* Cysteine and methionine metabolism_Homo sapiens_hsa002701.53009456
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50646171
38Folate biosynthesis_Homo sapiens_hsa007901.49316574
39Biosynthesis of amino acids_Homo sapiens_hsa012301.43154184
40Tyrosine metabolism_Homo sapiens_hsa003501.41073471
41Bile secretion_Homo sapiens_hsa049761.30719429
42Pyruvate metabolism_Homo sapiens_hsa006201.27830560
43Sulfur metabolism_Homo sapiens_hsa009201.27117930
44Fatty acid elongation_Homo sapiens_hsa000621.27026398
45Carbon metabolism_Homo sapiens_hsa012001.24694021
46Starch and sucrose metabolism_Homo sapiens_hsa005001.14635253
47Fat digestion and absorption_Homo sapiens_hsa049751.13189101
48Steroid biosynthesis_Homo sapiens_hsa001001.07269363
49Arginine and proline metabolism_Homo sapiens_hsa003301.04895942
50ABC transporters_Homo sapiens_hsa020101.04759647
51Sulfur relay system_Homo sapiens_hsa041221.01164414
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98043527
53Vitamin digestion and absorption_Homo sapiens_hsa049770.97351084
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.94680907
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90674825
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.90243027
57One carbon pool by folate_Homo sapiens_hsa006700.90040451
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89252285
59Pentose phosphate pathway_Homo sapiens_hsa000300.85003675
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75116253
61Glutathione metabolism_Homo sapiens_hsa004800.71797907
62Lysine degradation_Homo sapiens_hsa003100.71588868
63Glycerolipid metabolism_Homo sapiens_hsa005610.69207200
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67433183
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56412626
66* Metabolic pathways_Homo sapiens_hsa011000.53359265
67Fructose and mannose metabolism_Homo sapiens_hsa000510.44648537
68Fatty acid biosynthesis_Homo sapiens_hsa000610.43997235
69Prion diseases_Homo sapiens_hsa050200.35543939
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.35385646
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32110410
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32037704
73Galactose metabolism_Homo sapiens_hsa000520.28675355
74Regulation of autophagy_Homo sapiens_hsa041400.26671096
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22795768
76Linoleic acid metabolism_Homo sapiens_hsa005910.20331157
77Pertussis_Homo sapiens_hsa051330.17475563
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16820371
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.16674263
80Insulin resistance_Homo sapiens_hsa049310.14281219
81Proteasome_Homo sapiens_hsa030500.05483610
82Glucagon signaling pathway_Homo sapiens_hsa049220.02559794
83AMPK signaling pathway_Homo sapiens_hsa041520.02029799
84Pyrimidine metabolism_Homo sapiens_hsa002400.00279864
85Collecting duct acid secretion_Homo sapiens_hsa04966-0.2543001
86Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2490030
87Type II diabetes mellitus_Homo sapiens_hsa04930-0.2457560
88African trypanosomiasis_Homo sapiens_hsa05143-0.2298298
89Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2293734
90Hepatitis C_Homo sapiens_hsa05160-0.2282950
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.2260413
92Circadian rhythm_Homo sapiens_hsa04710-0.2233450
93Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2188605
94Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2180921
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.2166716
96Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2114636
97Purine metabolism_Homo sapiens_hsa00230-0.2102315
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.1847756
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1794810
100Amoebiasis_Homo sapiens_hsa05146-0.1792450
101Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1548536
102Ether lipid metabolism_Homo sapiens_hsa00565-0.1498350
103Sphingolipid metabolism_Homo sapiens_hsa00600-0.1465502
104Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1455336
105Other glycan degradation_Homo sapiens_hsa00511-0.1388875
106Renin-angiotensin system_Homo sapiens_hsa04614-0.1255514
107Insulin signaling pathway_Homo sapiens_hsa04910-0.1213711
108Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1191316
109Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1178523
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0588443
111Mineral absorption_Homo sapiens_hsa04978-0.0490445
112Serotonergic synapse_Homo sapiens_hsa04726-0.0197477

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