BHMT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.65308379
2L-phenylalanine catabolic process (GO:0006559)7.65308379
3epoxygenase P450 pathway (GO:0019373)7.57592934
4omega-hydroxylase P450 pathway (GO:0097267)7.39226412
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.33344415
6L-phenylalanine metabolic process (GO:0006558)7.33344415
7aromatic amino acid family catabolic process (GO:0009074)6.98413452
8indole-containing compound catabolic process (GO:0042436)6.39197363
9indolalkylamine catabolic process (GO:0046218)6.39197363
10tryptophan catabolic process (GO:0006569)6.39197363
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.22372142
12kynurenine metabolic process (GO:0070189)6.14492544
13tryptophan metabolic process (GO:0006568)6.00316187
14glyoxylate metabolic process (GO:0046487)5.98636544
15bile acid biosynthetic process (GO:0006699)5.94636358
16drug metabolic process (GO:0017144)5.94516500
17oxidative demethylation (GO:0070989)5.79061026
18urea cycle (GO:0000050)5.63438347
19urea metabolic process (GO:0019627)5.63438347
20cysteine metabolic process (GO:0006534)5.58498085
21serine family amino acid catabolic process (GO:0009071)5.55202910
22negative regulation of fibrinolysis (GO:0051918)5.50661887
23high-density lipoprotein particle remodeling (GO:0034375)5.47072818
24alpha-linolenic acid metabolic process (GO:0036109)5.43681192
25sulfur amino acid catabolic process (GO:0000098)5.39287190
26regulation of fibrinolysis (GO:0051917)5.34351793
27protein carboxylation (GO:0018214)5.29112115
28peptidyl-glutamic acid carboxylation (GO:0017187)5.29112115
29regulation of protein activation cascade (GO:2000257)5.19356307
30nitrogen cycle metabolic process (GO:0071941)5.18939482
31phenylpropanoid metabolic process (GO:0009698)5.18531610
32complement activation, alternative pathway (GO:0006957)5.14657903
33aromatic amino acid family metabolic process (GO:0009072)5.12734446
34regulation of plasminogen activation (GO:0010755)5.11823874
35bile acid metabolic process (GO:0008206)5.08390858
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.00468457
37homocysteine metabolic process (GO:0050667)4.96582246
38ethanol metabolic process (GO:0006067)4.91395362
39regulation of complement activation (GO:0030449)4.83787568
40tyrosine metabolic process (GO:0006570)4.83589573
41regulation of cholesterol esterification (GO:0010872)4.81075795
42lysine metabolic process (GO:0006553)4.81003750
43lysine catabolic process (GO:0006554)4.81003750
44regulation of triglyceride catabolic process (GO:0010896)4.80109250
45alpha-amino acid catabolic process (GO:1901606)4.78490626
46reverse cholesterol transport (GO:0043691)4.77609013
47negative regulation of blood coagulation (GO:0030195)4.71493884
48negative regulation of hemostasis (GO:1900047)4.71493884
49polyketide metabolic process (GO:0030638)4.71087107
50doxorubicin metabolic process (GO:0044598)4.71087107
51daunorubicin metabolic process (GO:0044597)4.71087107
52protein-lipid complex remodeling (GO:0034368)4.68529743
53macromolecular complex remodeling (GO:0034367)4.68529743
54plasma lipoprotein particle remodeling (GO:0034369)4.68529743
55glycine metabolic process (GO:0006544)4.66105929
56aminoglycoside antibiotic metabolic process (GO:0030647)4.61008293
57* amino-acid betaine metabolic process (GO:0006577)4.58707760
58acylglycerol homeostasis (GO:0055090)4.57749156
59triglyceride homeostasis (GO:0070328)4.57749156
60cellular ketone body metabolic process (GO:0046950)4.53464870
61response to mercury ion (GO:0046689)4.52647702
62indolalkylamine metabolic process (GO:0006586)4.51878984
63negative regulation of sterol transport (GO:0032372)4.49301471
64negative regulation of cholesterol transport (GO:0032375)4.49301471
65phospholipid efflux (GO:0033700)4.48216776
66amine catabolic process (GO:0009310)4.47955063
67cellular biogenic amine catabolic process (GO:0042402)4.47955063
68serine family amino acid metabolic process (GO:0009069)4.47917047
69cellular amino acid catabolic process (GO:0009063)4.41386869
70alkaloid metabolic process (GO:0009820)4.37101077
71coenzyme catabolic process (GO:0009109)4.34172437
72negative regulation of coagulation (GO:0050819)4.33632935
73bile acid and bile salt transport (GO:0015721)4.32802151
74imidazole-containing compound metabolic process (GO:0052803)4.31494642
75glutamate metabolic process (GO:0006536)4.29661677
76intestinal cholesterol absorption (GO:0030299)4.26564978
77plasma lipoprotein particle clearance (GO:0034381)4.26064328
78serine family amino acid biosynthetic process (GO:0009070)4.25961240
79cellular glucuronidation (GO:0052695)4.25476590
80negative regulation of wound healing (GO:0061045)4.24528420
81negative regulation of protein activation cascade (GO:2000258)4.20282241
82benzene-containing compound metabolic process (GO:0042537)4.19970138
83drug catabolic process (GO:0042737)4.18882789
84acute-phase response (GO:0006953)4.14724064
85cellular modified amino acid catabolic process (GO:0042219)4.14169341
86flavonoid metabolic process (GO:0009812)4.13385050
87cholesterol efflux (GO:0033344)4.13247918
88arginine metabolic process (GO:0006525)4.06322407
89regulation of humoral immune response (GO:0002920)4.06018602
90positive regulation of blood coagulation (GO:0030194)4.05098497
91positive regulation of hemostasis (GO:1900048)4.05098497
92aldehyde catabolic process (GO:0046185)4.01287411
93dicarboxylic acid biosynthetic process (GO:0043650)3.98243915
94ethanol oxidation (GO:0006069)3.98202531
95primary alcohol catabolic process (GO:0034310)3.95598132
96fibrinolysis (GO:0042730)3.94740448
97plasma lipoprotein particle assembly (GO:0034377)3.94715280
98ketone body metabolic process (GO:1902224)3.92000251
99low-density lipoprotein particle remodeling (GO:0034374)3.90394006
100hormone catabolic process (GO:0042447)3.87249446
101carboxylic acid catabolic process (GO:0046395)3.85977726
102organic acid catabolic process (GO:0016054)3.85977726
103blood coagulation, intrinsic pathway (GO:0007597)3.83715635
104short-chain fatty acid metabolic process (GO:0046459)3.82585267
105fat-soluble vitamin biosynthetic process (GO:0042362)3.82062694
106urate metabolic process (GO:0046415)3.81882222
107positive regulation of lipoprotein lipase activity (GO:0051006)3.81620761
108positive regulation of triglyceride lipase activity (GO:0061365)3.81620761
109glucuronate metabolic process (GO:0019585)3.81333340
110uronic acid metabolic process (GO:0006063)3.81333340
111regulation of bile acid biosynthetic process (GO:0070857)3.79872547
112positive regulation of coagulation (GO:0050820)3.79593019
113* S-adenosylmethionine metabolic process (GO:0046500)3.75017884
114heme transport (GO:0015886)3.72316528
115cofactor catabolic process (GO:0051187)3.71983837
116drug transmembrane transport (GO:0006855)3.71944411
117acetyl-CoA metabolic process (GO:0006084)3.71520793
118very-low-density lipoprotein particle assembly (GO:0034379)3.71212644
119cholesterol homeostasis (GO:0042632)3.70006080
120NAD biosynthetic process (GO:0009435)3.69410093
121exogenous drug catabolic process (GO:0042738)3.69320884
122negative regulation of lipase activity (GO:0060192)3.68324635
123phospholipid homeostasis (GO:0055091)3.65729536
124complement activation, classical pathway (GO:0006958)3.65414677
125sterol homeostasis (GO:0055092)3.64327594
126pyridine nucleotide biosynthetic process (GO:0019363)3.64169222
127nicotinamide nucleotide biosynthetic process (GO:0019359)3.64169222
128positive regulation of lipid catabolic process (GO:0050996)3.62622036
129protein activation cascade (GO:0072376)3.62169601
130xenobiotic metabolic process (GO:0006805)3.61791007
131complement activation (GO:0006956)3.61101680
132cytolysis (GO:0019835)3.53706497
133sodium-independent organic anion transport (GO:0043252)3.51774955
134positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.51129426
135negative regulation of complement activation (GO:0045916)3.45042145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.45915031
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21239813
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.14313874
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.47149358
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.30006226
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.20707702
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.72117209
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.18210009
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.89766245
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.07772608
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04715529
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9464585
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95264309
14TRIM28_21343339_ChIP-Seq_HEK293_Human1.78699296
15ESR1_20079471_ChIP-ChIP_T-47D_Human1.68108201
16HTT_18923047_ChIP-ChIP_STHdh_Human1.54489901
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.52532881
18HNF4A_19822575_ChIP-Seq_HepG2_Human1.43771880
19RXRA_24833708_ChIP-Seq_LIVER_Mouse1.31607131
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31137161
21CLOCK_20551151_ChIP-Seq_293T_Human1.30068527
22GATA1_22025678_ChIP-Seq_K562_Human1.29227481
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24940070
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.23794855
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.07297707
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06192122
27KAP1_22055183_ChIP-Seq_ESCs_Mouse1.05639336
28TP53_18474530_ChIP-ChIP_U2OS_Human1.05096347
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02552165
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01426226
31HNFA_21074721_ChIP-Seq_CACO-2_Human1.00722248
32CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96932808
33CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96595052
34IGF1R_20145208_ChIP-Seq_DFB_Human0.95780578
35POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95126834
36GBX2_23144817_ChIP-Seq_PC3_Human0.94729597
37PHF8_20622853_ChIP-Seq_HELA_Human0.94031178
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93729464
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93205751
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92924112
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92812002
42ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89358406
43SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89354134
44AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88400005
45PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87936985
46ER_23166858_ChIP-Seq_MCF-7_Human0.87415615
47CJUN_26792858_Chip-Seq_BT549_Human0.87229777
48NFYA_21822215_ChIP-Seq_K562_Human0.85094111
49SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84474514
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84314096
51SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83747088
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83381962
53GATA4_25053715_ChIP-Seq_YYC3_Human0.82574566
54RARA_24833708_ChIP-Seq_LIVER_Mouse0.82272351
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81771993
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81731708
57FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80942187
58GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.79368405
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78581164
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.77894954
61SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77612133
62KLF5_20875108_ChIP-Seq_MESCs_Mouse0.76737393
63GATA6_21074721_ChIP-Seq_CACO-2_Human0.76288911
64CBP_20019798_ChIP-Seq_JUKART_Human0.76199084
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.76199084
66ETV2_25802403_ChIP-Seq_MESCs_Mouse0.76175400
67RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74401063
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.71944480
69RARB_24833708_ChIP-Seq_LIVER_Mouse0.70750621
70SOX2_21211035_ChIP-Seq_LN229_Human0.69860127
71CBX2_22325352_ChIP-Seq_293T-Rex_Human0.69564106
72RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69275800
73ETV1_20927104_ChIP-Seq_GIST48_Human0.69189261
74OCT4_18555785_Chip-Seq_ESCs_Mouse0.68944880
75BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68349651
76ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.67108988
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.67097471
78EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.66808444
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.66310358
80TCF4_22108803_ChIP-Seq_LS180_Human0.66087625
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.66059035
82NFYB_21822215_ChIP-Seq_K562_Human0.65875274
83FOXA1_21572438_ChIP-Seq_LNCaP_Human0.65201187
84IRF8_22096565_ChIP-ChIP_GC-B_Human0.65057437
85SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65010522
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.64977495
87SMAD1_18555785_Chip-Seq_ESCs_Mouse0.64785119
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.64753079
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64631570
90RAC3_21632823_ChIP-Seq_H3396_Human0.64133328
91AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63972549
92SOX2_20726797_ChIP-Seq_SW620_Human0.63951123
93ZNF263_19887448_ChIP-Seq_K562_Human0.60821112
94CEBPB_22108803_ChIP-Seq_LS180_Human0.59286495
95STAT1_17558387_ChIP-Seq_HELA_Human0.59258336
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.57812845
97* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.55201169
98* AR_20517297_ChIP-Seq_VCAP_Human0.53909905
99MYC_19915707_ChIP-ChIP_AK7_Human0.53907931
100ESET_19884257_ChIP-Seq_ESCs_Mouse0.53380988
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.53108208
102NRF2_20460467_ChIP-Seq_MEFs_Mouse0.53108208
103ESR1_21235772_ChIP-Seq_MCF-7_Human0.53080200
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52984928
105STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52819064
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52362911
107FOXA1_25552417_ChIP-Seq_VCAP_Human0.51968502
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.51804768
109FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50901223
110PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.50653778
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.50171495
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.50071870
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.49640727
114CBP_21632823_ChIP-Seq_H3396_Human0.49526048
115TAF2_19829295_ChIP-Seq_ESCs_Human0.49224739
116IRF1_19129219_ChIP-ChIP_H3396_Human0.47087460
117EGR1_19032775_ChIP-ChIP_M12_Human0.46113459
118* P53_21459846_ChIP-Seq_SAOS-2_Human0.45850925
119PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45211083
120PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.44931236
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.42931158
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.42443401
123OCT4_21477851_ChIP-Seq_ESCs_Mouse0.41461378
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.41406182
125LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.41335609
126FOXH1_21741376_ChIP-Seq_EPCs_Human0.41070141
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41028092
128TAF15_26573619_Chip-Seq_HEK293_Human0.39906204
129CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.39808902
130MYC_27129775_Chip-Seq_CORNEA_Mouse0.39632439
131* LXR_22292898_ChIP-Seq_THP-1_Human0.39538161
132PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.39324657
133SPI1_26923725_Chip-Seq_HPCs_Mouse0.37878737
134NCOR_22424771_ChIP-Seq_293T_Human0.37836220
135CDX2_22108803_ChIP-Seq_LS180_Human0.37663817
136BCAT_22108803_ChIP-Seq_LS180_Human0.37583898
137GATA1_19941827_ChIP-Seq_MEL_Mouse0.37332401
138STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36857899
139NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.36701406
140CDX2_20551321_ChIP-Seq_CACO-2_Human0.36507466
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.36416576
142FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.36056834
143EZH2_27294783_Chip-Seq_NPCs_Mouse0.35817876

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.27480188
2MP0005360_urolithiasis7.71538204
3MP0005085_abnormal_gallbladder_physiolo6.39062378
4MP0005365_abnormal_bile_salt6.16006045
5MP0008875_abnormal_xenobiotic_pharmacok5.14028894
6MP0003806_abnormal_nucleotide_metabolis4.12972787
7MP0003252_abnormal_bile_duct3.85680262
8MP0010329_abnormal_lipoprotein_level3.53668509
9MP0009840_abnormal_foam_cell3.32100904
10MP0003195_calcinosis3.04282561
11MP0005332_abnormal_amino_acid2.99715058
12MP0005083_abnormal_biliary_tract2.93678572
13MP0001666_abnormal_nutrient_absorption2.54320691
14MP0004019_abnormal_vitamin_homeostasis2.44142002
15MP0003191_abnormal_cellular_cholesterol2.30234278
16MP0000609_abnormal_liver_physiology2.14714105
17MP0002138_abnormal_hepatobiliary_system2.11650750
18MP0002118_abnormal_lipid_homeostasis2.08572877
19MP0005319_abnormal_enzyme/_coenzyme1.83994717
20MP0003868_abnormal_feces_composition1.81928704
21MP0001764_abnormal_homeostasis1.80297301
22MP0005451_abnormal_body_composition1.63974007
23MP0005584_abnormal_enzyme/coenzyme_acti1.60277104
24MP0009697_abnormal_copulation1.57941950
25MP0009643_abnormal_urine_homeostasis1.39423973
26MP0003186_abnormal_redox_activity1.35494375
27MP0003011_delayed_dark_adaptation1.34575393
28MP0003656_abnormal_erythrocyte_physiolo1.22966698
29MP0000598_abnormal_liver_morphology1.16143186
30MP0005647_abnormal_sex_gland1.14119968
31MP0005636_abnormal_mineral_homeostasis1.07711933
32MP0009764_decreased_sensitivity_to1.05840665
33MP0000604_amyloidosis0.98637199
34MP0009763_increased_sensitivity_to0.96733077
35MP0002876_abnormal_thyroid_physiology0.92858278
36MP0003705_abnormal_hypodermis_morpholog0.92392153
37MP0002254_reproductive_system_inflammat0.90617892
38MP0009642_abnormal_blood_homeostasis0.89122118
39MP0008469_abnormal_protein_level0.88960446
40MP0010368_abnormal_lymphatic_system0.88382144
41MP0006036_abnormal_mitochondrial_physio0.85775596
42MP0005408_hypopigmentation0.85278061
43MP0005670_abnormal_white_adipose0.85170761
44MP0005084_abnormal_gallbladder_morpholo0.82899145
45MP0001661_extended_life_span0.82306515
46MP0005376_homeostasis/metabolism_phenot0.78895924
47MP0001915_intracranial_hemorrhage0.77882681
48MP0009765_abnormal_xenobiotic_induced0.77110959
49MP0002078_abnormal_glucose_homeostasis0.76246765
50MP0003879_abnormal_hair_cell0.75193170
51MP0001756_abnormal_urination0.74854985
52MP0002971_abnormal_brown_adipose0.71993134
53MP0005187_abnormal_penis_morphology0.70757929
54MP0005535_abnormal_body_temperature0.70413261
55MP0005220_abnormal_exocrine_pancreas0.69657785
56MP0003718_maternal_effect0.68873039
57MP0005334_abnormal_fat_pad0.68092020
58MP0006035_abnormal_mitochondrial_morpho0.65264125
59MP0003959_abnormal_lean_body0.62355812
60MP0004130_abnormal_muscle_cell0.62040663
61MP0003690_abnormal_glial_cell0.61083266
62MP0005266_abnormal_metabolism0.60314234
63MP0005395_other_phenotype0.60291827
64MP0009053_abnormal_anal_canal0.58522525
65MP0002136_abnormal_kidney_physiology0.58422185
66MP0003329_amyloid_beta_deposits0.54870949
67MP0000639_abnormal_adrenal_gland0.53980498
68MP0005023_abnormal_wound_healing0.53412199
69MP0005448_abnormal_energy_balance0.51774225
70MP0005164_abnormal_response_to0.51430015
71MP0002282_abnormal_trachea_morphology0.51371554
72MP0004272_abnormal_basement_membrane0.51018623
73MP0003950_abnormal_plasma_membrane0.49928600
74MP0004381_abnormal_hair_follicle0.49410670
75MP0010386_abnormal_urinary_bladder0.47763168
76MP0005464_abnormal_platelet_physiology0.46800718
77MP0002928_abnormal_bile_duct0.46420884
78MP0004043_abnormal_pH_regulation0.46414345
79MP0002822_catalepsy0.45748073
80MP0003638_abnormal_response/metabolism_0.45641099
81MP0004782_abnormal_surfactant_physiolog0.43152076
82MP0003953_abnormal_hormone_level0.42929252
83MP0008873_increased_physiological_sensi0.41107536
84MP0003724_increased_susceptibility_to0.41073616
85MP0008874_decreased_physiological_sensi0.40139717
86MP0009672_abnormal_birth_weight0.38796260
87MP0008872_abnormal_physiological_respon0.38418479
88MP0009785_altered_susceptibility_to0.36078818
89MP0002168_other_aberrant_phenotype0.35272477
90MP0002132_abnormal_respiratory_system0.34668425
91MP0000579_abnormal_nail_morphology0.34376870
92MP0000230_abnormal_systemic_arterial0.34229577
93MP0009115_abnormal_fat_cell0.33675498
94MP0005375_adipose_tissue_phenotype0.33112858
95MP0005666_abnormal_adipose_tissue0.33037501
96MP0005058_abnormal_lysosome_morphology0.32843256
97MP0003436_decreased_susceptibility_to0.31573250
98MP0009780_abnormal_chondrocyte_physiolo0.31037802
99MP0005166_decreased_susceptibility_to0.30196557
100MP0002909_abnormal_adrenal_gland0.30152313
101MP0002796_impaired_skin_barrier0.30116818
102MP0006082_CNS_inflammation0.29469306
103MP0001765_abnormal_ion_homeostasis0.29400075
104MP0005248_abnormal_Harderian_gland0.29244468
105MP0003075_altered_response_to0.28587926
106MP0002837_dystrophic_cardiac_calcinosis0.28364163
107MP0002249_abnormal_larynx_morphology0.27788874
108MP0002970_abnormal_white_adipose0.27488388
109MP0005551_abnormal_eye_electrophysiolog0.27325430
110MP0001845_abnormal_inflammatory_respons0.27116075
111MP0004883_abnormal_blood_vessel0.26724128
112MP0000467_abnormal_esophagus_morphology0.26463350
113MP0000003_abnormal_adipose_tissue0.26420999
114MP0000249_abnormal_blood_vessel0.25769661
115MP0002135_abnormal_kidney_morphology0.24905402
116MP0001881_abnormal_mammary_gland0.24763851
117MP0001243_abnormal_dermal_layer0.24422650
118MP0001944_abnormal_pancreas_morphology0.24150485
119MP0001851_eye_inflammation0.23850260
120MP0000538_abnormal_urinary_bladder0.23696783
121MP0002128_abnormal_blood_circulation0.23031869
122MP0005197_abnormal_uvea_morphology0.23021029
123MP0002332_abnormal_exercise_endurance0.21343903
124MP0003646_muscle_fatigue0.21099411
125MP0005452_abnormal_adipose_tissue0.20022031

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.39341534
2Deep venous thrombosis (HP:0002625)7.14681917
3Intrahepatic cholestasis (HP:0001406)7.11519891
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.56931646
5Prolonged partial thromboplastin time (HP:0003645)6.47038077
6Hypobetalipoproteinemia (HP:0003563)6.23358387
7Xanthomatosis (HP:0000991)6.16315881
8Hyperlipoproteinemia (HP:0010980)5.46052687
9Complement deficiency (HP:0004431)5.11406918
10Hyperglycinemia (HP:0002154)4.83930459
11Joint hemorrhage (HP:0005261)4.80381573
12Hyperammonemia (HP:0001987)4.68497326
13Hypolipoproteinemia (HP:0010981)4.67556362
14Hyperglycinuria (HP:0003108)4.41792837
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.35978478
16Abnormality of sulfur amino acid metabolism (HP:0004339)4.33829462
17Epidermoid cyst (HP:0200040)4.31949279
18Abnormality of glycine metabolism (HP:0010895)4.31148907
19Abnormality of serine family amino acid metabolism (HP:0010894)4.31148907
20Ketosis (HP:0001946)4.30546381
21Abnormality of the common coagulation pathway (HP:0010990)4.27622118
22Abnormality of methionine metabolism (HP:0010901)4.26889805
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.26786122
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.26645095
25Hypoalphalipoproteinemia (HP:0003233)4.10221622
26Fat malabsorption (HP:0002630)4.03589521
27Abnormality of pyrimidine metabolism (HP:0004353)3.99219222
28Hypoglycemic coma (HP:0001325)3.77358581
29Nephritis (HP:0000123)3.70698005
30Abnormality of complement system (HP:0005339)3.68983463
31Conjugated hyperbilirubinemia (HP:0002908)3.65870157
32Abnormality of the intrinsic pathway (HP:0010989)3.64495615
33Abnormality of fatty-acid metabolism (HP:0004359)3.48854786
34Hypercholesterolemia (HP:0003124)3.48763286
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.34485898
36Abnormality of serum amino acid levels (HP:0003112)3.33247628
37Abnormality of nucleobase metabolism (HP:0010932)3.29483328
38Hyperbilirubinemia (HP:0002904)3.24448508
39Delayed CNS myelination (HP:0002188)3.22336447
40Ketoacidosis (HP:0001993)3.07711766
41Steatorrhea (HP:0002570)3.04538464
42Gout (HP:0001997)2.98933057
43Spontaneous abortion (HP:0005268)2.95642573
44Hepatocellular carcinoma (HP:0001402)2.94985426
45Abnormality of purine metabolism (HP:0004352)2.94615380
46Osteomalacia (HP:0002749)2.91491471
47Myocardial infarction (HP:0001658)2.89894110
48Metabolic acidosis (HP:0001942)2.88990989
49Hypochromic microcytic anemia (HP:0004840)2.82255552
50Lethargy (HP:0001254)2.80931555
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.79257389
52Dicarboxylic aciduria (HP:0003215)2.79257389
53Vascular calcification (HP:0004934)2.71930941
54Systemic lupus erythematosus (HP:0002725)2.64455462
55Skin nodule (HP:0200036)2.57520880
56Hyperphosphaturia (HP:0003109)2.56990524
57Cerebral edema (HP:0002181)2.54545935
58Spastic diplegia (HP:0001264)2.47295801
59Irritability (HP:0000737)2.46082735
60Acanthocytosis (HP:0001927)2.40404540
61Cardiovascular calcification (HP:0011915)2.39038282
62Glomerulonephritis (HP:0000099)2.37399931
63Hypoglycemic seizures (HP:0002173)2.37251736
64Purpura (HP:0000979)2.36681615
65Abnormality of vitamin metabolism (HP:0100508)2.33274949
66Malnutrition (HP:0004395)2.33063681
67Neonatal onset (HP:0003623)2.32696030
68Reduced antithrombin III activity (HP:0001976)2.29937109
69Mitral stenosis (HP:0001718)2.29207486
70Enlarged kidneys (HP:0000105)2.25600445
71Abnormal gallbladder morphology (HP:0012437)2.25532479
72Generalized aminoaciduria (HP:0002909)2.24895980
73Fair hair (HP:0002286)2.24639431
74Vomiting (HP:0002013)2.21901262
75Pancreatitis (HP:0001733)2.20361113
76Cholelithiasis (HP:0001081)2.19562659
77Arthropathy (HP:0003040)2.19312924
78Brushfield spots (HP:0001088)2.18822318
79Recurrent gram-negative bacterial infections (HP:0005420)2.18049271
80Sensorimotor neuropathy (HP:0007141)2.17173816
81Proximal tubulopathy (HP:0000114)2.15296705
82Alkalosis (HP:0001948)2.14739772
83Pulmonary embolism (HP:0002204)2.11788919
84Amyloidosis (HP:0011034)2.11369001
85Opisthotonus (HP:0002179)2.10114142
86Cholecystitis (HP:0001082)2.09923196
87Abnormal gallbladder physiology (HP:0012438)2.09923196
88Gingival bleeding (HP:0000225)2.08367327
89Rickets (HP:0002748)2.07952690
90Abnormal urine phosphate concentration (HP:0012599)2.07349915
91Hyperuricemia (HP:0002149)2.06871772
92Increased purine levels (HP:0004368)2.06871772
93Menorrhagia (HP:0000132)2.06485771
94Esophageal varix (HP:0002040)2.05097445
95Thrombophlebitis (HP:0004418)2.03632651
96Late onset (HP:0003584)2.02394737
97Renal cortical cysts (HP:0000803)1.98072544
98Hydroxyprolinuria (HP:0003080)1.95324743
99Abnormality of proline metabolism (HP:0010907)1.95324743
100Hypophosphatemic rickets (HP:0004912)1.94275600
101Poikilocytosis (HP:0004447)1.91438454
102Abnormality of the gallbladder (HP:0005264)1.91065824
103Hyperinsulinemic hypoglycemia (HP:0000825)1.90777403
104Abnormality of urine glucose concentration (HP:0011016)1.89745852
105Glycosuria (HP:0003076)1.89745852
106Facial shape deformation (HP:0011334)1.89665724
107Potter facies (HP:0002009)1.89665724
108Abnormal enzyme/coenzyme activity (HP:0012379)1.88983486
109Bile duct proliferation (HP:0001408)1.88943997
110Abnormal biliary tract physiology (HP:0012439)1.88943997
111Elevated alkaline phosphatase (HP:0003155)1.86302294
112Hemorrhage of the eye (HP:0011885)1.85476401
113Increased circulating renin level (HP:0000848)1.83291409
114Abnormal cartilage morphology (HP:0002763)1.83183995
115Abnormality of transition element cation homeostasis (HP:0011030)1.82977668
116Joint swelling (HP:0001386)1.82765926
117Elevated hepatic transaminases (HP:0002910)1.81884515
118Cerebral palsy (HP:0100021)1.80098748
119Abnormality of alkaline phosphatase activity (HP:0004379)1.76043149
120Bifid scrotum (HP:0000048)1.74331115
121Abnormality of the Achilles tendon (HP:0005109)1.72036033
122Increased mean platelet volume (HP:0011877)1.67862805
123Impaired platelet aggregation (HP:0003540)1.67823606
124Abnormal platelet function (HP:0011869)1.67823606
125Abnormality of iron homeostasis (HP:0011031)1.66956780
126Gangrene (HP:0100758)1.64141231
127Hypophosphatemia (HP:0002148)1.61596962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.71080315
2FGFR44.80315529
3SIK14.20577769
4ERN13.92124098
5INSRR3.10537526
6TAOK32.95479599
7ERBB42.82344237
8MYLK2.49471707
9MAP2K42.21315215
10PIK3CA2.17702282
11MST1R2.14679132
12PIK3CG2.04053877
13TYK21.91340784
14MAPK111.84230454
15ABL21.62353248
16FLT31.59893337
17LATS11.55529791
18MAPKAPK31.54805124
19PINK11.48732318
20STK38L1.48727173
21DAPK21.46389972
22PKN21.41434560
23MAP3K121.38410700
24NTRK31.33666043
25NEK91.32185045
26KDR1.28042000
27AKT31.25070877
28IRAK31.24174069
29MAP4K21.19363367
30TRPM71.19170286
31FRK1.18204872
32PDK31.16942692
33PDK41.16942692
34FGFR21.15908131
35MAP3K41.15886334
36PTK61.13816042
37JAK21.13420942
38PRKAA21.11722945
39GRK11.06510649
40MAPK151.05568702
41FER1.04365192
42TRIB31.02059968
43GRK61.01379966
44EIF2AK11.01050279
45MAP3K71.00656923
46MAP2K30.99221839
47CAMKK20.98273625
48ADRBK20.97815020
49MAP3K140.97274669
50MAPK40.94574685
51JAK10.94164905
52GRK70.92170093
53PRKCZ0.91712156
54STK390.89665046
55SCYL20.89241587
56PRKG10.87709954
57ERBB20.87624454
58TIE10.87060921
59MAP3K30.84343323
60WNK30.82662665
61NLK0.82600047
62PRKACA0.81504020
63TBK10.80469437
64MAPK120.79253071
65PRKCE0.79051768
66MAP3K110.78041938
67PRKACG0.76611124
68PRKAA10.76100870
69SGK30.75840894
70OBSCN0.75130602
71SGK20.75023520
72STK160.73529899
73STK380.73350297
74MET0.72530199
75BCR0.72030271
76CAMK2G0.71599007
77KIT0.71555463
78GSK3A0.71373121
79MAPK70.71196750
80MAP2K60.70103056
81BMPR1B0.67114453
82TAOK20.65761689
83ADRBK10.65421558
84SGK2230.63819624
85SGK4940.63819624
86DYRK1B0.63643187
87EPHA30.63635039
88CDK60.63471344
89PDK20.63081396
90EPHB10.63015102
91MUSK0.61587384
92ACVR1B0.56458164
93CSNK1D0.56195486
94MAP2K70.56136312
95IKBKE0.55880139
96CSK0.54873868
97CSNK1G10.54527209
98DDR20.54478948
99PRKCG0.52484607
100MAP3K60.50908101
101MAP3K20.50299608
102MAP3K100.49611605
103PDPK10.48516095
104CDK40.46981267
105RPS6KA30.46301571
106TGFBR20.45213199
107PRKCQ0.45054054
108WNK40.44646056
109BRSK20.44526511
110MAP3K50.44349123
111PRKACB0.44340048
112PTK20.43918190
113EPHA40.43382728
114SRC0.42850874
115PRKCB0.41762278
116OXSR10.41685621
117GRK50.41657393
118IGF1R0.40941734
119SGK10.38029249
120CSF1R0.37451527
121PKN10.36864541
122CAMK1D0.36269478
123PAK20.36214403
124FGFR30.35313420
125PBK0.34270599
126MTOR0.34090776
127RET0.33808545
128STK30.33474486
129IRAK20.30943059
130IRAK10.28964935
131EGFR0.28686735
132PDK10.27965942
133PRKCA0.27469286
134MAP2K10.25010924
135CSNK1G30.23981162
136ABL10.23117359
137EPHA20.22331554
138CAMK40.21086592
139RIPK10.20778782
140MAP3K130.20527313
141CSNK1G20.20465767

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.40456387
2Nitrogen metabolism_Homo sapiens_hsa009103.37330628
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33141242
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.30296903
5Arginine biosynthesis_Homo sapiens_hsa002202.99918554
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73431285
7Tryptophan metabolism_Homo sapiens_hsa003802.69208989
8Complement and coagulation cascades_Homo sapiens_hsa046102.66011138
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.65298210
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63611320
11Fatty acid degradation_Homo sapiens_hsa000712.47411526
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44346918
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30308600
14Butanoate metabolism_Homo sapiens_hsa006502.25375841
15Peroxisome_Homo sapiens_hsa041462.13448193
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10499632
17Propanoate metabolism_Homo sapiens_hsa006401.98310006
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.91719489
19Chemical carcinogenesis_Homo sapiens_hsa052041.90500991
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90030081
21Histidine metabolism_Homo sapiens_hsa003401.89372540
22PPAR signaling pathway_Homo sapiens_hsa033201.82526646
23Fatty acid metabolism_Homo sapiens_hsa012121.80522264
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.78463925
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.77441306
26beta-Alanine metabolism_Homo sapiens_hsa004101.76926265
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72182673
28Retinol metabolism_Homo sapiens_hsa008301.70868617
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70114703
30Staphylococcus aureus infection_Homo sapiens_hsa051501.68078146
31Caffeine metabolism_Homo sapiens_hsa002321.62576326
32Selenocompound metabolism_Homo sapiens_hsa004501.60813807
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57442993
34Phenylalanine metabolism_Homo sapiens_hsa003601.56824453
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51791899
36Bile secretion_Homo sapiens_hsa049761.43819454
37Tyrosine metabolism_Homo sapiens_hsa003501.42308477
38Pyruvate metabolism_Homo sapiens_hsa006201.38936448
39Sulfur metabolism_Homo sapiens_hsa009201.36353936
40Fatty acid elongation_Homo sapiens_hsa000621.33805714
41Folate biosynthesis_Homo sapiens_hsa007901.30171052
42Biosynthesis of amino acids_Homo sapiens_hsa012301.26287446
43* Cysteine and methionine metabolism_Homo sapiens_hsa002701.25878501
44Starch and sucrose metabolism_Homo sapiens_hsa005001.24976631
45Vitamin B6 metabolism_Homo sapiens_hsa007501.24384397
46Steroid biosynthesis_Homo sapiens_hsa001001.23191209
47Carbon metabolism_Homo sapiens_hsa012001.18070190
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.16847791
49ABC transporters_Homo sapiens_hsa020101.14676967
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13196756
51Fat digestion and absorption_Homo sapiens_hsa049751.10434431
52Arginine and proline metabolism_Homo sapiens_hsa003301.02513421
53Vitamin digestion and absorption_Homo sapiens_hsa049771.00916888
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.00654345
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97065793
56Sulfur relay system_Homo sapiens_hsa041220.95415744
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93155842
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87578750
59Lysine degradation_Homo sapiens_hsa003100.81156387
60One carbon pool by folate_Homo sapiens_hsa006700.79459598
61Pentose phosphate pathway_Homo sapiens_hsa000300.73931802
62Glutathione metabolism_Homo sapiens_hsa004800.71861638
63Glycerolipid metabolism_Homo sapiens_hsa005610.71591895
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67456655
65* Metabolic pathways_Homo sapiens_hsa011000.50860873
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50094537
67Fatty acid biosynthesis_Homo sapiens_hsa000610.45800101
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33574015
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30957251
70Fructose and mannose metabolism_Homo sapiens_hsa000510.30779966
71Prion diseases_Homo sapiens_hsa050200.28690339
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26172483
73Linoleic acid metabolism_Homo sapiens_hsa005910.25746954
74Galactose metabolism_Homo sapiens_hsa000520.24069713
75Pertussis_Homo sapiens_hsa051330.23673858
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.22112813
77Insulin resistance_Homo sapiens_hsa049310.16986642
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.16041639
79Glucagon signaling pathway_Homo sapiens_hsa049220.04833701
80Other glycan degradation_Homo sapiens_hsa005110.04484784
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00670606
82Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2445795
83Mineral absorption_Homo sapiens_hsa04978-0.2432892
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2427299
85Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2348128
86Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2336271
87Pyrimidine metabolism_Homo sapiens_hsa00240-0.2308557
88Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2202279
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2117505
90Ether lipid metabolism_Homo sapiens_hsa00565-0.2066814
91Type II diabetes mellitus_Homo sapiens_hsa04930-0.2053980
92Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1987283
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1913476
94African trypanosomiasis_Homo sapiens_hsa05143-0.1885312
95Hepatitis C_Homo sapiens_hsa05160-0.1872380
96Amoebiasis_Homo sapiens_hsa05146-0.1599035
97Renin-angiotensin system_Homo sapiens_hsa04614-0.1575284
98Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1325289
99Insulin signaling pathway_Homo sapiens_hsa04910-0.1309998
100Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1268329
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1130748
102Sphingolipid metabolism_Homo sapiens_hsa00600-0.1071754
103Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0835739
104Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0723433
105Circadian rhythm_Homo sapiens_hsa04710-0.0600666
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0433834
107AMPK signaling pathway_Homo sapiens_hsa04152-0.0073194
108Serotonergic synapse_Homo sapiens_hsa04726-0.0066600
109Regulation of autophagy_Homo sapiens_hsa04140-0.0026429

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