BICD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of two human homologs of Drosophila bicaudal-D. It has been implicated in COPI-independent membrane transport from the Golgi apparatus to the endoplasmic reticulum. Two alternative splice variants have been described. Other alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.38019839
2presynaptic membrane organization (GO:0097090)4.87425719
3neuron cell-cell adhesion (GO:0007158)4.70729030
4pyrimidine nucleobase catabolic process (GO:0006208)4.48093689
5postsynaptic membrane organization (GO:0001941)4.37663473
6ionotropic glutamate receptor signaling pathway (GO:0035235)4.21799874
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.02697681
8behavioral response to nicotine (GO:0035095)3.94220423
9neuronal action potential propagation (GO:0019227)3.92759416
10startle response (GO:0001964)3.91997636
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.89694475
12vocalization behavior (GO:0071625)3.89095814
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.88808187
14synaptic transmission, glutamatergic (GO:0035249)3.86582857
15glutamate receptor signaling pathway (GO:0007215)3.86513154
16protein localization to synapse (GO:0035418)3.86382963
17behavioral response to ethanol (GO:0048149)3.78454497
18negative regulation of synaptic transmission, GABAergic (GO:0032229)3.74889714
19cell migration in hindbrain (GO:0021535)3.61599350
20neuron-neuron synaptic transmission (GO:0007270)3.60740731
21gamma-aminobutyric acid signaling pathway (GO:0007214)3.55925267
22regulation of short-term neuronal synaptic plasticity (GO:0048172)3.55792928
23nucleobase catabolic process (GO:0046113)3.47314677
24regulation of glutamate receptor signaling pathway (GO:1900449)3.43577419
25G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.39418402
26regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.37763521
27righting reflex (GO:0060013)3.35776019
28limb bud formation (GO:0060174)3.32883011
29transmission of nerve impulse (GO:0019226)3.27495904
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.23366332
31positive regulation of synapse assembly (GO:0051965)3.20116812
32neurotransmitter-gated ion channel clustering (GO:0072578)3.18013521
33regulation of respiratory system process (GO:0044065)3.14680829
34neuron recognition (GO:0008038)3.12478665
35negative regulation of cytosolic calcium ion concentration (GO:0051481)3.12440917
36paraxial mesoderm development (GO:0048339)3.11883026
37dendrite morphogenesis (GO:0048813)3.10446980
38forebrain neuron differentiation (GO:0021879)3.09363915
39establishment of mitochondrion localization (GO:0051654)3.09070703
40spinal cord development (GO:0021510)3.07661441
41regulation of synapse assembly (GO:0051963)3.04259517
42layer formation in cerebral cortex (GO:0021819)3.04212348
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.00486915
44olfactory bulb development (GO:0021772)2.97561823
45regulation of postsynaptic membrane potential (GO:0060078)2.97415913
46negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94387826
47cerebral cortex radially oriented cell migration (GO:0021799)2.93711304
48axon extension (GO:0048675)2.92246216
49serotonin receptor signaling pathway (GO:0007210)2.91097867
50regulation of synaptic vesicle exocytosis (GO:2000300)2.91045249
51regulation of respiratory gaseous exchange (GO:0043576)2.90737168
52synaptic vesicle exocytosis (GO:0016079)2.89371975
53positive regulation of membrane potential (GO:0045838)2.85601906
54regulation of synaptic transmission, glutamatergic (GO:0051966)2.80901491
55positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80352942
56retinal ganglion cell axon guidance (GO:0031290)2.79972250
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.79879010
58synapse assembly (GO:0007416)2.77822322
59mechanosensory behavior (GO:0007638)2.76299224
60cerebellar Purkinje cell differentiation (GO:0021702)2.75536974
61axonal fasciculation (GO:0007413)2.75333843
62protein localization to cilium (GO:0061512)2.74693987
63adult walking behavior (GO:0007628)2.74560866
64neuronal ion channel clustering (GO:0045161)2.74113996
65intraciliary transport (GO:0042073)2.74074862
66long-term memory (GO:0007616)2.72250514
67membrane hyperpolarization (GO:0060081)2.71651618
68central nervous system projection neuron axonogenesis (GO:0021952)2.71441446
69inner ear receptor stereocilium organization (GO:0060122)2.70975796
70positive regulation of action potential (GO:0045760)2.70513347
71inner ear receptor cell development (GO:0060119)2.69716749
72apical protein localization (GO:0045176)2.69542603
73membrane depolarization (GO:0051899)2.68778186
74positive regulation of neurotransmitter secretion (GO:0001956)2.67216103
75mitochondrion transport along microtubule (GO:0047497)2.67206550
76establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.67206550
77regulation of synaptic transmission, GABAergic (GO:0032228)2.66969583
78opioid receptor signaling pathway (GO:0038003)2.66542485
79long-chain fatty acid biosynthetic process (GO:0042759)2.66308685
80developmental pigmentation (GO:0048066)2.65247273
81negative regulation of neurotransmitter transport (GO:0051589)2.63296938
82detection of calcium ion (GO:0005513)2.61127818
83cranial nerve structural organization (GO:0021604)2.60958945
84urinary tract smooth muscle contraction (GO:0014848)2.60755434
85regulation of pigment cell differentiation (GO:0050932)2.60343457
86neuronal action potential (GO:0019228)2.59189328
87dendrite development (GO:0016358)2.59047979
88membrane depolarization during action potential (GO:0086010)2.58292062
89synaptic vesicle maturation (GO:0016188)2.58258743
90central nervous system neuron axonogenesis (GO:0021955)2.58257615
91neuromuscular synaptic transmission (GO:0007274)2.58240816
92regulation of synapse maturation (GO:0090128)2.56808568
93reflex (GO:0060004)2.56529554
94regulation of timing of cell differentiation (GO:0048505)2.55906184
95regulation of neurotransmitter secretion (GO:0046928)2.55508641
96cyclic nucleotide catabolic process (GO:0009214)2.54998287
97regulation of synaptic vesicle transport (GO:1902803)2.54660856
98calcium ion import (GO:0070509)2.54374582
99regulation of dendritic spine morphogenesis (GO:0061001)2.53634290
100kidney morphogenesis (GO:0060993)2.53447749
101L-amino acid import (GO:0043092)2.53308060
102embryonic foregut morphogenesis (GO:0048617)2.52771766
103adult behavior (GO:0030534)2.51240030
104sympathetic nervous system development (GO:0048485)2.49683949
105negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.48412012
106negative regulation of translation, ncRNA-mediated (GO:0040033)2.48412012
107regulation of translation, ncRNA-mediated (GO:0045974)2.48412012
108regulation of axon guidance (GO:1902667)2.47899761
109ganglion development (GO:0061548)2.47427803
110regulation of synapse structural plasticity (GO:0051823)2.46882076
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.46031695
112auditory receptor cell stereocilium organization (GO:0060088)2.45621935
113appendage development (GO:0048736)2.45008714
114limb development (GO:0060173)2.45008714
115neuron migration (GO:0001764)2.44807360
116neuron projection extension involved in neuron projection guidance (GO:1902284)2.44597798
117axon extension involved in axon guidance (GO:0048846)2.44597798
118artery development (GO:0060840)2.44596035
119neuron projection extension (GO:1990138)2.44486939
120positive regulation of dendritic spine morphogenesis (GO:0061003)2.43930524
121adult locomotory behavior (GO:0008344)2.43458854
122calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.43118462
123cAMP catabolic process (GO:0006198)2.42001869
124gamma-aminobutyric acid transport (GO:0015812)2.41332154
125neural tube formation (GO:0001841)2.40901163
126central nervous system myelination (GO:0022010)2.40677969
127axon ensheathment in central nervous system (GO:0032291)2.40677969
128regulation of synapse organization (GO:0050807)2.40227933
129learning (GO:0007612)2.39383896
130nonmotile primary cilium assembly (GO:0035058)2.38961170
131positive regulation of dendritic spine development (GO:0060999)2.38772914
132positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.38712680
133regulation of growth hormone secretion (GO:0060123)2.38398911
134exploration behavior (GO:0035640)2.38139928
135synapse organization (GO:0050808)2.38108182
136hippocampus development (GO:0021766)2.37928663
137G-protein coupled receptor internalization (GO:0002031)2.37103259
138synaptic vesicle docking involved in exocytosis (GO:0016081)2.36926393
139cerebral cortex cell migration (GO:0021795)2.36420620
140axonogenesis (GO:0007409)2.36265711
141dendritic spine morphogenesis (GO:0060997)2.35430076
142glutamate secretion (GO:0014047)2.35368421
143negative regulation of dendrite development (GO:2000171)2.34790030
144ephrin receptor signaling pathway (GO:0048013)2.33860515
145response to auditory stimulus (GO:0010996)2.33755485
146polyketide metabolic process (GO:0030638)2.33451817
147doxorubicin metabolic process (GO:0044598)2.33451817
148daunorubicin metabolic process (GO:0044597)2.33451817
149auditory behavior (GO:0031223)2.32959525
150cerebellar granule cell differentiation (GO:0021707)2.31462611
151regulation of telomere maintenance (GO:0032204)2.29211112
152cell proliferation in forebrain (GO:0021846)2.28737164
153cardiac ventricle formation (GO:0003211)2.27212781
154atrial cardiac muscle cell action potential (GO:0086014)2.26870198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.20213793
2GBX2_23144817_ChIP-Seq_PC3_Human4.61467974
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.08007896
4* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.69916908
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.63777371
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.50435973
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47480020
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.41104175
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38953114
10TAF15_26573619_Chip-Seq_HEK293_Human2.38784910
11* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22080696
12IGF1R_20145208_ChIP-Seq_DFB_Human2.22030803
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19654564
14ZNF274_21170338_ChIP-Seq_K562_Hela2.17519357
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.15728885
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15457111
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.12430984
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10289193
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10261811
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06835763
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04363917
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.99917479
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.99075948
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98471420
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97456343
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.96758540
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93879444
28* P300_19829295_ChIP-Seq_ESCs_Human1.93515294
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91025404
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87431522
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87046962
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87046962
33* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86174809
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85480416
35SMAD4_21799915_ChIP-Seq_A2780_Human1.80400606
36REST_21632747_ChIP-Seq_MESCs_Mouse1.77378437
37FUS_26573619_Chip-Seq_HEK293_Human1.75372647
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.74778280
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.74366854
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.73146256
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67117592
42EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.66822452
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66145268
44* PIAS1_25552417_ChIP-Seq_VCAP_Human1.65498067
45DROSHA_22980978_ChIP-Seq_HELA_Human1.64332376
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.63882458
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.61992475
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.60115568
49E2F1_18555785_Chip-Seq_ESCs_Mouse1.59946267
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.59390815
51P53_22387025_ChIP-Seq_ESCs_Mouse1.59295703
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57992322
53RNF2_27304074_Chip-Seq_NSC_Mouse1.57820169
54* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57275604
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.55348291
56SUZ12_18555785_Chip-Seq_ESCs_Mouse1.54109162
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54072759
58VDR_22108803_ChIP-Seq_LS180_Human1.53624622
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51998699
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51220190
61AR_21572438_ChIP-Seq_LNCaP_Human1.50959313
62CMYC_18555785_Chip-Seq_ESCs_Mouse1.50238442
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48522437
64STAT3_18555785_Chip-Seq_ESCs_Mouse1.47713623
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.45400812
66ER_23166858_ChIP-Seq_MCF-7_Human1.45218905
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45068064
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44907379
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44786948
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44581274
71* STAT3_23295773_ChIP-Seq_U87_Human1.43662306
72EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.42591842
73P300_18555785_Chip-Seq_ESCs_Mouse1.41688205
74NMYC_18555785_Chip-Seq_ESCs_Mouse1.40476484
75EWS_26573619_Chip-Seq_HEK293_Human1.40116222
76* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38887863
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38200036
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37480941
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36946249
80SOX9_26525672_Chip-Seq_HEART_Mouse1.36244272
81SOX2_18555785_Chip-Seq_ESCs_Mouse1.35754303
82RUNX1_27457419_Chip-Seq_LIVER_Mouse1.34383098
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33490913
84* TCF4_23295773_ChIP-Seq_U87_Human1.33349572
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30626116
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30073428
87* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29677015
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29405361
89* AR_25329375_ChIP-Seq_VCAP_Human1.29006003
90OCT4_18555785_Chip-Seq_ESCs_Mouse1.28570398
91* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27385622
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26195151
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26195151
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25623826
95* RUNX2_22187159_ChIP-Seq_PCA_Human1.24358393
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22883777
97KLF4_18555785_Chip-Seq_ESCs_Mouse1.20965707
98PU1_27457419_Chip-Seq_LIVER_Mouse1.20793761
99* TAL1_26923725_Chip-Seq_HPCs_Mouse1.20446959
100TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19956816
101TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19911726
102* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19739246
103CTCF_18555785_Chip-Seq_ESCs_Mouse1.19513531
104ZFX_18555785_Chip-Seq_ESCs_Mouse1.18305181
105* KDM2B_26808549_Chip-Seq_REH_Human1.17249993
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17130450
107CBP_20019798_ChIP-Seq_JUKART_Human1.17130450
108RING1B_27294783_Chip-Seq_ESCs_Mouse1.17014574
109SMAD1_18555785_Chip-Seq_ESCs_Mouse1.16074578
110ESRRB_18555785_Chip-Seq_ESCs_Mouse1.14527319
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14411416
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12500468
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10812981
114REST_18959480_ChIP-ChIP_MESCs_Mouse1.10075374
115RING1B_27294783_Chip-Seq_NPCs_Mouse1.08057018
116SOX2_16153702_ChIP-ChIP_HESCs_Human1.07248157
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06964587
118* TP53_18474530_ChIP-ChIP_U2OS_Human1.06960313
119TP63_19390658_ChIP-ChIP_HaCaT_Human1.06125526
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05926247
121SOX2_21211035_ChIP-Seq_LN229_Gbm1.05102714
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04761407
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04703874
124SMAD3_21741376_ChIP-Seq_ESCs_Human1.04547331
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04114830
126* WT1_19549856_ChIP-ChIP_CCG9911_Human1.03981620
127KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03340784
128BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02764127
129AR_19668381_ChIP-Seq_PC3_Human1.01832171
130TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01823707
131ISL1_27105846_Chip-Seq_CPCs_Mouse1.01369136
132POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01097080
133JUN_21703547_ChIP-Seq_K562_Human1.00447295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.46302306
2MP0001188_hyperpigmentation3.55904634
3MP0004859_abnormal_synaptic_plasticity2.98619200
4MP0001968_abnormal_touch/_nociception2.72912535
5MP0002735_abnormal_chemical_nociception2.64250130
6MP0003635_abnormal_synaptic_transmissio2.57274702
7MP0006292_abnormal_olfactory_placode2.57175132
8MP0001486_abnormal_startle_reflex2.56297022
9MP0009046_muscle_twitch2.53934898
10MP0009745_abnormal_behavioral_response2.47796185
11MP0005423_abnormal_somatic_nervous2.45568434
12MP0003890_abnormal_embryonic-extraembry2.35933205
13MP0005409_darkened_coat_color2.34027673
14MP0006276_abnormal_autonomic_nervous2.31440615
15MP0004270_analgesia2.27830667
16MP0005645_abnormal_hypothalamus_physiol2.27435341
17MP0002734_abnormal_mechanical_nocicepti2.25663645
18MP0002272_abnormal_nervous_system2.25563600
19MP0002736_abnormal_nociception_after2.19390444
20MP0002572_abnormal_emotion/affect_behav2.19366354
21MP0002064_seizures2.18541412
22MP0001986_abnormal_taste_sensitivity2.18105054
23MP0005646_abnormal_pituitary_gland2.12638732
24MP0002063_abnormal_learning/memory/cond2.04023597
25MP0002067_abnormal_sensory_capabilities2.03437584
26MP0003136_yellow_coat_color2.01065761
27MP0000566_synostosis1.98600872
28MP0003787_abnormal_imprinting1.95379905
29MP0005171_absent_coat_pigmentation1.90641209
30MP0003123_paternal_imprinting1.84318691
31MP0002876_abnormal_thyroid_physiology1.82209273
32MP0000015_abnormal_ear_pigmentation1.81560135
33MP0001984_abnormal_olfaction1.80604412
34MP0001501_abnormal_sleep_pattern1.76504320
35MP0000778_abnormal_nervous_system1.72502219
36MP0002557_abnormal_social/conspecific_i1.69215632
37MP0004742_abnormal_vestibular_system1.67036145
38MP0001970_abnormal_pain_threshold1.66822605
39MP0002184_abnormal_innervation1.65915585
40MP0001440_abnormal_grooming_behavior1.64616549
41MP0004142_abnormal_muscle_tone1.62039707
42MP0002638_abnormal_pupillary_reflex1.61934118
43MP0002733_abnormal_thermal_nociception1.59698812
44MP0008789_abnormal_olfactory_epithelium1.58337066
45MP0002102_abnormal_ear_morphology1.58126036
46MP0010386_abnormal_urinary_bladder1.55764129
47MP0001502_abnormal_circadian_rhythm1.53738428
48MP0003861_abnormal_nervous_system1.45701213
49MP0008057_abnormal_DNA_replication1.42499190
50MP0005551_abnormal_eye_electrophysiolog1.42191407
51MP0003937_abnormal_limbs/digits/tail_de1.39253716
52MP0004133_heterotaxia1.37029627
53MP0005187_abnormal_penis_morphology1.36604143
54MP0003879_abnormal_hair_cell1.35692689
55MP0005386_behavior/neurological_phenoty1.32573979
56MP0004924_abnormal_behavior1.32573979
57MP0000631_abnormal_neuroendocrine_gland1.32264768
58MP0008569_lethality_at_weaning1.31337861
59MP0001963_abnormal_hearing_physiology1.30077465
60MP0000569_abnormal_digit_pigmentation1.28232295
61MP0001529_abnormal_vocalization1.27320497
62MP0002233_abnormal_nose_morphology1.27262956
63MP0005379_endocrine/exocrine_gland_phen1.26253539
64MP0005174_abnormal_tail_pigmentation1.25515995
65MP0002653_abnormal_ependyma_morphology1.22866337
66MP0001299_abnormal_eye_distance/1.20641225
67MP0003119_abnormal_digestive_system1.20212138
68MP0001905_abnormal_dopamine_level1.19705637
69MP0000026_abnormal_inner_ear1.18749445
70MP0000955_abnormal_spinal_cord1.18595455
71MP0001485_abnormal_pinna_reflex1.18161744
72MP0002882_abnormal_neuron_morphology1.16582553
73MP0006072_abnormal_retinal_apoptosis1.12969961
74MP0000372_irregular_coat_pigmentation1.11948285
75MP0003122_maternal_imprinting1.11127607
76MP0002277_abnormal_respiratory_mucosa1.10979005
77MP0003183_abnormal_peptide_metabolism1.09481355
78MP0003755_abnormal_palate_morphology1.07710803
79MP0000534_abnormal_ureter_morphology1.04086300
80MP0002752_abnormal_somatic_nervous1.02912408
81MP0003385_abnormal_body_wall1.02851689
82MP0001293_anophthalmia1.02735991
83MP0004043_abnormal_pH_regulation1.01633243
84MP0002234_abnormal_pharynx_morphology1.00893271
85MP0004381_abnormal_hair_follicle1.00784044
86MP0002081_perinatal_lethality0.99068999
87MP0002697_abnormal_eye_size0.98668840
88MP0001286_abnormal_eye_development0.98568587
89MP0002751_abnormal_autonomic_nervous0.98546333
90MP0000579_abnormal_nail_morphology0.97924483
91MP0002066_abnormal_motor_capabilities/c0.97910576
92MP0003942_abnormal_urinary_system0.97757777
93MP0005253_abnormal_eye_physiology0.97263739
94MP0000428_abnormal_craniofacial_morphol0.95792579
95MP0002095_abnormal_skin_pigmentation0.95278506
96MP0000537_abnormal_urethra_morphology0.94863447
97MP0009780_abnormal_chondrocyte_physiolo0.94317545
98MP0000681_abnormal_thyroid_gland0.93372231
99MP0002229_neurodegeneration0.92866109
100MP0002909_abnormal_adrenal_gland0.91212328
101MP0005195_abnormal_posterior_eye0.90667968
102MP0004145_abnormal_muscle_electrophysio0.89706945
103MP0003935_abnormal_craniofacial_develop0.88735929
104MP0004885_abnormal_endolymph0.87488457
105MP0002938_white_spotting0.85782802
106MP0009379_abnormal_foot_pigmentation0.84913305
107MP0004811_abnormal_neuron_physiology0.84677084
108MP0009053_abnormal_anal_canal0.83694690
109MP0002822_catalepsy0.83478266
110MP0003938_abnormal_ear_development0.83254912
111MP0005391_vision/eye_phenotype0.82629100
112MP0009250_abnormal_appendicular_skeleto0.82507384
113MP0008260_abnormal_autophagy0.82003346
114MP0005499_abnormal_olfactory_system0.78277731
115MP0005394_taste/olfaction_phenotype0.78277731
116MP0001664_abnormal_digestion0.76628201
117MP0000678_abnormal_parathyroid_gland0.76303089
118MP0003315_abnormal_perineum_morphology0.76110955
119MP0002116_abnormal_craniofacial_bone0.74858696
120MP0008877_abnormal_DNA_methylation0.74616462
121MP0002177_abnormal_outer_ear0.73748004
122MP0003121_genomic_imprinting0.73552381
123MP0002152_abnormal_brain_morphology0.73326959
124MP0002163_abnormal_gland_morphology0.72435723
125MP0005075_abnormal_melanosome_morpholog0.71972390
126MP0003633_abnormal_nervous_system0.71488436
127MP0000049_abnormal_middle_ear0.67125369
128MP0000920_abnormal_myelination0.67056789
129MP0003631_nervous_system_phenotype0.65740799
130MP0002009_preneoplasia0.62963584
131MP0009697_abnormal_copulation0.61798364
132MP0001177_atelectasis0.59411075
133MP0002069_abnormal_eating/drinking_beha0.58234517

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.74661811
2Febrile seizures (HP:0002373)5.07352051
3Epileptic encephalopathy (HP:0200134)3.52944870
4Focal seizures (HP:0007359)3.36507884
5Hypothermia (HP:0002045)3.23865217
6Progressive cerebellar ataxia (HP:0002073)3.20325074
7Hyperventilation (HP:0002883)3.16511414
8Hepatoblastoma (HP:0002884)3.14589452
9Broad-based gait (HP:0002136)3.13947959
10Atonic seizures (HP:0010819)3.11125391
11Gaze-evoked nystagmus (HP:0000640)3.04521720
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.00838834
13Absent/shortened dynein arms (HP:0200106)3.00838834
14Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99604235
15Volvulus (HP:0002580)2.99447871
16Abnormality of the labia minora (HP:0012880)2.95635172
17Protruding tongue (HP:0010808)2.93349938
18Medial flaring of the eyebrow (HP:0010747)2.74247618
19Abnormal hair whorl (HP:0010721)2.73361146
20Abnormal ciliary motility (HP:0012262)2.65722223
21Absent speech (HP:0001344)2.63953299
22Fair hair (HP:0002286)2.63099029
23Generalized hypopigmentation of hair (HP:0011358)2.57688021
24Gait imbalance (HP:0002141)2.55086766
25Chromsome breakage (HP:0040012)2.44619324
26Blue irides (HP:0000635)2.40342259
27Nephrogenic diabetes insipidus (HP:0009806)2.38760142
28Intestinal atresia (HP:0011100)2.38546739
29Congenital primary aphakia (HP:0007707)2.37253818
30Dialeptic seizures (HP:0011146)2.31572687
31Cortical dysplasia (HP:0002539)2.31333070
32Generalized tonic-clonic seizures (HP:0002069)2.28996947
33True hermaphroditism (HP:0010459)2.27122814
34Optic nerve hypoplasia (HP:0000609)2.27001752
35Abnormal respiratory epithelium morphology (HP:0012253)2.24344583
36Abnormal respiratory motile cilium morphology (HP:0005938)2.24344583
37Drooling (HP:0002307)2.21666966
38Excessive salivation (HP:0003781)2.21666966
39Pancreatic fibrosis (HP:0100732)2.21431486
40Nonprogressive disorder (HP:0003680)2.21407651
41Thyroid-stimulating hormone excess (HP:0002925)2.21351791
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.21267412
43Short 4th metacarpal (HP:0010044)2.21267412
44Aplasia/Hypoplasia of the sternum (HP:0006714)2.21128730
45Decreased central vision (HP:0007663)2.21097277
46Myokymia (HP:0002411)2.20347115
47Colon cancer (HP:0003003)2.19735953
48Aplasia/Hypoplasia of the fovea (HP:0008060)2.17229299
49Hypoplasia of the fovea (HP:0007750)2.17229299
50Abnormality of the lower motor neuron (HP:0002366)2.17028201
51Vertebral arch anomaly (HP:0008438)2.16631035
52Absence seizures (HP:0002121)2.14539498
53Congenital sensorineural hearing impairment (HP:0008527)2.13662666
54Abnormal respiratory motile cilium physiology (HP:0012261)2.12731293
55Septo-optic dysplasia (HP:0100842)2.10447529
56Genital tract atresia (HP:0001827)2.08644566
57Upper limb muscle weakness (HP:0003484)2.07730412
58Tubulointerstitial nephritis (HP:0001970)2.07402521
59Renal hypoplasia (HP:0000089)2.07385232
60Megalencephaly (HP:0001355)2.07361218
61Type I transferrin isoform profile (HP:0003642)2.04789773
62Aqueductal stenosis (HP:0002410)2.03245109
63Congenital stationary night blindness (HP:0007642)2.02232094
64Vaginal atresia (HP:0000148)2.02015425
65Limb dystonia (HP:0002451)2.00370604
66Cutaneous finger syndactyly (HP:0010554)1.99912950
67Chronic hepatic failure (HP:0100626)1.97070587
68Genetic anticipation (HP:0003743)1.96539264
69Abnormality of the fovea (HP:0000493)1.96166699
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.95278462
71Lissencephaly (HP:0001339)1.95176213
72Nephronophthisis (HP:0000090)1.90825347
73Inability to walk (HP:0002540)1.90227808
74Truncal ataxia (HP:0002078)1.90113000
75Abnormality of calcium-phosphate metabolism (HP:0100530)1.89915654
76Narrow forehead (HP:0000341)1.88246927
77Ulnar claw (HP:0001178)1.88188611
78Aplasia/Hypoplasia of the lens (HP:0008063)1.87675041
79White forelock (HP:0002211)1.87246892
80Attenuation of retinal blood vessels (HP:0007843)1.86743823
81Vitreoretinal degeneration (HP:0000655)1.86721197
82Visual hallucinations (HP:0002367)1.85807119
83Scanning speech (HP:0002168)1.85248731
84Shawl scrotum (HP:0000049)1.84958742
85Widely spaced teeth (HP:0000687)1.84864860
86Patchy hypopigmentation of hair (HP:0011365)1.84860412
87Rib fusion (HP:0000902)1.84855632
88Abnormality of the renal collecting system (HP:0004742)1.84581691
89Diastasis recti (HP:0001540)1.84480211
90Abnormality of incisor morphology (HP:0011063)1.84452775
91Abnormality of salivation (HP:0100755)1.82708994
92Abnormality of the corticospinal tract (HP:0002492)1.82459277
93Parakeratosis (HP:0001036)1.81412536
94Duplicated collecting system (HP:0000081)1.81038014
95Pancreatic cysts (HP:0001737)1.80268071
96Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80219972
97Poor coordination (HP:0002370)1.79805867
98Progressive inability to walk (HP:0002505)1.79722283
99Preaxial hand polydactyly (HP:0001177)1.79245725
100Oligodactyly (hands) (HP:0001180)1.78479628
101Micropenis (HP:0000054)1.78094625
102Median cleft lip (HP:0000161)1.78019509
103Absent septum pellucidum (HP:0001331)1.77961442
104Osteomalacia (HP:0002749)1.77845037
105Cupped ear (HP:0000378)1.77592013
106Absent eyebrow (HP:0002223)1.77304005
107Patellar aplasia (HP:0006443)1.76934310
108Retinal dysplasia (HP:0007973)1.76695143
109Esotropia (HP:0000565)1.76541636
110Aplasia/Hypoplasia of the tibia (HP:0005772)1.76105930
111Facial hemangioma (HP:0000329)1.75691606
112Bradycardia (HP:0001662)1.75475882
113Gastroesophageal reflux (HP:0002020)1.75313103
114Cutaneous syndactyly (HP:0012725)1.75004727
115Epileptiform EEG discharges (HP:0011182)1.74264996
116Agitation (HP:0000713)1.74255474
117High anterior hairline (HP:0009890)1.73471175
118Abnormality of the renal medulla (HP:0100957)1.73435792
119Gastrointestinal atresia (HP:0002589)1.73151693
120Hypsarrhythmia (HP:0002521)1.72487854
121Pachygyria (HP:0001302)1.72233797
122Hemiparesis (HP:0001269)1.71996023
123Abnormality of the diencephalon (HP:0010662)1.71969499
124Esophageal atresia (HP:0002032)1.71807863
125Prostate neoplasm (HP:0100787)1.71579353
126EEG with generalized epileptiform discharges (HP:0011198)1.70593554
127Decreased circulating renin level (HP:0003351)1.70441324
128Postaxial hand polydactyly (HP:0001162)1.70411539
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69688496
130Abnormality of secondary sexual hair (HP:0009888)1.69227069
131Abnormality of the axillary hair (HP:0100134)1.69227069
132Exotropia (HP:0000577)1.69157688
133Neoplasm of the adrenal cortex (HP:0100641)1.68026148
134Abnormality of midbrain morphology (HP:0002418)1.67791982
135Molar tooth sign on MRI (HP:0002419)1.67791982
136Postaxial foot polydactyly (HP:0001830)1.66504803
137Hypomagnesemia (HP:0002917)1.65540312
138Abnormality of the aortic arch (HP:0012303)1.64044383
139Labial hypoplasia (HP:0000066)1.63588931
140Bifid tongue (HP:0010297)1.62994804
141Astigmatism (HP:0000483)1.62258253
142Action tremor (HP:0002345)1.61841009
143Tented upper lip vermilion (HP:0010804)1.61578584
144Male pseudohermaphroditism (HP:0000037)1.61129673
145Aplasia cutis congenita (HP:0001057)1.60842198
146Oligodactyly (HP:0012165)1.59985648
147Specific learning disability (HP:0001328)1.59476405
148Aplasia/Hypoplasia of the patella (HP:0006498)1.58829726
149Neoplasm of the oral cavity (HP:0100649)1.57689165
150Intellectual disability, moderate (HP:0002342)1.57165771
151Morphological abnormality of the middle ear (HP:0008609)1.56781893
152Abnormality of the antihelix (HP:0009738)1.56775176
153Anophthalmia (HP:0000528)1.56312946
154Growth hormone deficiency (HP:0000824)1.54430177
155Impaired vibration sensation in the lower limbs (HP:0002166)1.54171945
156Scrotal hypoplasia (HP:0000046)1.53198358
157Short foot (HP:0001773)1.51935053
158Small hand (HP:0200055)1.51649437
159Polyphagia (HP:0002591)1.51603288
160Abnormality of the 4th metacarpal (HP:0010012)1.50848832

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.38004153
2TNIK4.49431244
3NTRK33.42349298
4LATS13.29016379
5MAP2K72.98724219
6INSRR2.30739612
7EPHA42.27255792
8MUSK2.12294516
9MAPK132.04030350
10STK161.93635325
11MARK11.92569310
12CAMK1G1.91423251
13MAP3K41.90259078
14CAMK1D1.81280310
15MKNK21.80546961
16PRPF4B1.79760689
17SIK31.70548721
18NEK61.69508004
19MAP4K21.49205856
20CDC71.47932076
21TRIM281.46769123
22MAP3K121.45771824
23YES11.43668176
24AKT31.36654176
25EIF2AK21.35218682
26OXSR11.32921089
27EPHB21.32848449
28ADRBK21.30531138
29BMPR21.27995292
30CAMKK21.26972390
31SGK21.22363178
32BMPR1B1.22124042
33ACVR1B1.20630043
34PLK41.18967828
35DYRK31.16126992
36IRAK31.13910744
37FES1.11622327
38CDK31.09743768
39CSNK1G11.09725910
40STK38L1.09540052
41NTRK21.09215483
42SGK2231.08970424
43SGK4941.08970424
44ZAK1.07267342
45CDK191.07219328
46TXK1.05027781
47CSNK1A1L1.04435142
48PRKD31.03974876
49RIPK41.03086801
50STK391.02589241
51IRAK21.00936545
52GRK10.99486777
53CSNK1G30.97257924
54GRK70.96959941
55MKNK10.96241635
56SIK20.94916883
57PLK20.94730202
58CAMK2B0.93847566
59FGFR20.92284298
60CAMK2A0.92016021
61PRKCE0.91555289
62PKN10.89846376
63PAK30.88648664
64WNK30.85536589
65TAF10.84839878
66KSR10.82023723
67NUAK10.81559253
68IRAK10.81378878
69CAMK10.79213172
70GRK50.78743230
71UHMK10.78694173
72CDK50.76913796
73TNK20.76191645
74WNK10.74647340
75BCR0.74419630
76IRAK40.73802507
77CAMK2D0.73507315
78DYRK1A0.72996748
79SRPK10.72680116
80PRKCG0.72637024
81MINK10.71076969
82MAP2K40.69440205
83PAK60.68821502
84SGK10.67830582
85EPHA30.66092424
86BRD40.65883287
87MAPKAPK50.65493311
88EIF2AK30.63203445
89TYRO30.61181889
90FGR0.59651760
91MAPK150.58910409
92TEC0.58240145
93STK30.57783344
94VRK10.56913842
95DAPK20.55516462
96MAP3K60.55075346
97CAMK40.53793421
98PRKG10.52117011
99MARK20.49195960
100CSNK1D0.48717406
101PLK30.48270462
102CSNK1E0.48242893
103SGK30.48018780
104FRK0.47953331
105MAP3K140.47852438
106HIPK20.47774792
107CCNB10.47409512
108PINK10.47339836
109PRKCZ0.46977521
110WNK40.46038476
111CAMKK10.45975001
112FER0.44271054
113MAP3K90.44251509
114NME10.44241355
115DYRK20.44222060
116TGFBR10.43198397
117LATS20.43173038
118CDK80.43005181
119PNCK0.42946795
120ATM0.42798850
121PRKACA0.42534193
122NTRK10.42303942
123NLK0.42112024
124CDK180.41421322
125CAMK2G0.41370902
126PIK3CA0.40612130
127NEK20.40567334
128PHKG20.39925782
129PHKG10.39925782
130RPS6KA40.39662046
131FGFR10.39518559
132PRKDC0.39286904
133CSNK1G20.38572652
134ERBB30.38184649
135ADRBK10.38044920
136DAPK10.37843973
137ERBB40.37166670
138CDK150.37106459
139CSNK1A10.36337361
140* GSK3B0.36010135
141PLK10.35404887
142TLK10.35403352
143STK110.32813977
144CDC42BPA0.32556990

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.19575675
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63953632
3Taste transduction_Homo sapiens_hsa047422.63714153
4Morphine addiction_Homo sapiens_hsa050322.56836768
5Glutamatergic synapse_Homo sapiens_hsa047242.41587101
6Circadian entrainment_Homo sapiens_hsa047132.25839888
7Synaptic vesicle cycle_Homo sapiens_hsa047212.25507323
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.24388931
9GABAergic synapse_Homo sapiens_hsa047272.22652253
10Serotonergic synapse_Homo sapiens_hsa047262.17373209
11Phototransduction_Homo sapiens_hsa047442.05174053
12Olfactory transduction_Homo sapiens_hsa047401.89462208
13Amphetamine addiction_Homo sapiens_hsa050311.87210291
14Insulin secretion_Homo sapiens_hsa049111.84853600
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77480585
16Collecting duct acid secretion_Homo sapiens_hsa049661.67927318
17Long-term potentiation_Homo sapiens_hsa047201.64747134
18Dopaminergic synapse_Homo sapiens_hsa047281.59183702
19Calcium signaling pathway_Homo sapiens_hsa040201.57932168
20Long-term depression_Homo sapiens_hsa047301.55071790
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54076555
22Basal cell carcinoma_Homo sapiens_hsa052171.53257348
23Salivary secretion_Homo sapiens_hsa049701.53101918
24Cholinergic synapse_Homo sapiens_hsa047251.50164234
25Hippo signaling pathway_Homo sapiens_hsa043901.47850413
26Hedgehog signaling pathway_Homo sapiens_hsa043401.45578713
27Cocaine addiction_Homo sapiens_hsa050301.39099498
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39032030
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31039353
30Steroid biosynthesis_Homo sapiens_hsa001001.27059529
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24777176
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23996544
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22171875
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21956600
35Renin secretion_Homo sapiens_hsa049241.18063842
36Sphingolipid metabolism_Homo sapiens_hsa006001.16186072
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15432802
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14447708
39Axon guidance_Homo sapiens_hsa043601.13038405
40cAMP signaling pathway_Homo sapiens_hsa040241.12675628
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09038942
42Ether lipid metabolism_Homo sapiens_hsa005651.07690415
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07225481
44Vibrio cholerae infection_Homo sapiens_hsa051101.06803090
45Circadian rhythm_Homo sapiens_hsa047101.04517391
46Colorectal cancer_Homo sapiens_hsa052101.02732443
47Fanconi anemia pathway_Homo sapiens_hsa034601.02193040
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00608153
49Oocyte meiosis_Homo sapiens_hsa041141.00204606
50Gastric acid secretion_Homo sapiens_hsa049710.97213207
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96467504
52Oxytocin signaling pathway_Homo sapiens_hsa049210.96449852
53Protein export_Homo sapiens_hsa030600.94985138
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94236032
55Lysine degradation_Homo sapiens_hsa003100.93692716
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92221481
57Oxidative phosphorylation_Homo sapiens_hsa001900.91876783
58Rheumatoid arthritis_Homo sapiens_hsa053230.91471542
59Type II diabetes mellitus_Homo sapiens_hsa049300.91433849
60Adherens junction_Homo sapiens_hsa045200.90935958
61Cell cycle_Homo sapiens_hsa041100.88799294
62Pancreatic secretion_Homo sapiens_hsa049720.88572101
63Autoimmune thyroid disease_Homo sapiens_hsa053200.87026354
64TGF-beta signaling pathway_Homo sapiens_hsa043500.86415740
65Ovarian steroidogenesis_Homo sapiens_hsa049130.85992224
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.85677422
67mRNA surveillance pathway_Homo sapiens_hsa030150.84512210
68MicroRNAs in cancer_Homo sapiens_hsa052060.83660060
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82766983
70ErbB signaling pathway_Homo sapiens_hsa040120.82078034
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81950185
72Type I diabetes mellitus_Homo sapiens_hsa049400.80774914
73GnRH signaling pathway_Homo sapiens_hsa049120.79851620
74Endometrial cancer_Homo sapiens_hsa052130.75339008
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75082436
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.73829987
77Alzheimers disease_Homo sapiens_hsa050100.72619093
78Alcoholism_Homo sapiens_hsa050340.72095154
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71128111
80Tight junction_Homo sapiens_hsa045300.70720486
81RNA degradation_Homo sapiens_hsa030180.69853229
82Glioma_Homo sapiens_hsa052140.69659630
83Melanogenesis_Homo sapiens_hsa049160.69404776
84Butanoate metabolism_Homo sapiens_hsa006500.68997264
85Rap1 signaling pathway_Homo sapiens_hsa040150.67677213
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67050225
87Ras signaling pathway_Homo sapiens_hsa040140.66939441
88Wnt signaling pathway_Homo sapiens_hsa043100.66117445
89Inositol phosphate metabolism_Homo sapiens_hsa005620.65588372
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64503886
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59356611
92Regulation of autophagy_Homo sapiens_hsa041400.59309479
93African trypanosomiasis_Homo sapiens_hsa051430.58777439
94Notch signaling pathway_Homo sapiens_hsa043300.58704463
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58475376
96MAPK signaling pathway_Homo sapiens_hsa040100.57056751
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56714793
98Gap junction_Homo sapiens_hsa045400.55632645
99Choline metabolism in cancer_Homo sapiens_hsa052310.54411328
100Propanoate metabolism_Homo sapiens_hsa006400.54381506
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53881249
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53282368
103Cardiac muscle contraction_Homo sapiens_hsa042600.51246675
104Allograft rejection_Homo sapiens_hsa053300.50475870
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49840337
106Asthma_Homo sapiens_hsa053100.48439412
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48276368
108Arachidonic acid metabolism_Homo sapiens_hsa005900.47166714
109Phagosome_Homo sapiens_hsa041450.45839872
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.45319450
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45255023
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44789904
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44071444
114Huntingtons disease_Homo sapiens_hsa050160.43398155
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42506385
116Glucagon signaling pathway_Homo sapiens_hsa049220.41917396
117Dorso-ventral axis formation_Homo sapiens_hsa043200.40843700
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.40079409
119RNA transport_Homo sapiens_hsa030130.39890842
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39499099
121Basal transcription factors_Homo sapiens_hsa030220.39321706
122Pathways in cancer_Homo sapiens_hsa052000.39140156
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38952999
124Linoleic acid metabolism_Homo sapiens_hsa005910.37689548
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36713339
126Non-homologous end-joining_Homo sapiens_hsa034500.36313811
127Graft-versus-host disease_Homo sapiens_hsa053320.35622744
128Chemokine signaling pathway_Homo sapiens_hsa040620.34760294
129Hematopoietic cell lineage_Homo sapiens_hsa046400.33775268
130Dilated cardiomyopathy_Homo sapiens_hsa054140.33362720
131Thyroid hormone synthesis_Homo sapiens_hsa049180.33345537
132Estrogen signaling pathway_Homo sapiens_hsa049150.33250549
133Mineral absorption_Homo sapiens_hsa049780.33143387
134Melanoma_Homo sapiens_hsa052180.31682631

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