BICD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)5.56649587
2hypotonic response (GO:0006971)4.99510547
3keratinization (GO:0031424)4.94334069
4regulation of water loss via skin (GO:0033561)4.91256680
5plasma membrane repair (GO:0001778)4.80611010
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.44265579
7cardiac myofibril assembly (GO:0055003)4.15383916
8sarcomere organization (GO:0045214)4.12214836
9keratinocyte differentiation (GO:0030216)4.08928531
10neutrophil activation involved in immune response (GO:0002283)3.97361167
11gland morphogenesis (GO:0022612)3.96146009
12detection of other organism (GO:0098543)3.86976812
13protein localization to endosome (GO:0036010)3.84800628
14negative regulation of potassium ion transmembrane transport (GO:1901380)3.82386283
15desmosome organization (GO:0002934)3.74968508
16detection of bacterium (GO:0016045)3.68780025
17myofibril assembly (GO:0030239)3.67293146
18cytoskeletal anchoring at plasma membrane (GO:0007016)3.63107502
19negative regulation of erythrocyte differentiation (GO:0045647)3.56563756
20positive regulation by organism of defense response of other organism involved in symbiotic interact3.39770761
21modulation by symbiont of host immune response (GO:0052553)3.39770761
22positive regulation by symbiont of host defense response (GO:0052509)3.39770761
23modulation by symbiont of host defense response (GO:0052031)3.39770761
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.39770761
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.39770761
26muscle filament sliding (GO:0030049)3.39338729
27actin-myosin filament sliding (GO:0033275)3.39338729
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.32039786
29regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.26725091
30response to muramyl dipeptide (GO:0032495)3.25598760
31keratinocyte proliferation (GO:0043616)3.22497487
32epithelial cell differentiation involved in prostate gland development (GO:0060742)3.22179449
33negative regulation of protein localization to cell surface (GO:2000009)3.21948737
34keratinocyte development (GO:0003334)3.20443500
35regulation of NFAT protein import into nucleus (GO:0051532)3.16610253
36pre-miRNA processing (GO:0031054)3.15219506
37negative regulation of cell killing (GO:0031342)3.09755478
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.09755478
39epidermal cell differentiation (GO:0009913)3.09023294
40mannose metabolic process (GO:0006013)3.08558837
41response to peptidoglycan (GO:0032494)3.08235108
42regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.05079754
43actomyosin structure organization (GO:0031032)3.03170822
44detection of external biotic stimulus (GO:0098581)2.99937443
45glucose catabolic process (GO:0006007)2.99611397
46central nervous system myelination (GO:0022010)2.97226393
47axon ensheathment in central nervous system (GO:0032291)2.97226393
48macrophage activation involved in immune response (GO:0002281)2.95062811
49cardiac muscle contraction (GO:0060048)2.94860372
50regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.94048124
51actin-mediated cell contraction (GO:0070252)2.93756375
52stress fiber assembly (GO:0043149)2.92412395
53cellular extravasation (GO:0045123)2.92110829
54positive regulation of gamma-delta T cell activation (GO:0046645)2.91448916
55embryonic camera-type eye morphogenesis (GO:0048596)2.90287219
56creatine metabolic process (GO:0006600)2.88965462
57negative regulation of glial cell proliferation (GO:0060253)2.88720621
58peptide cross-linking (GO:0018149)2.88647856
59regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.87690455
60cell communication involved in cardiac conduction (GO:0086065)2.87168295
61regulation of actin filament-based movement (GO:1903115)2.85180741
62receptor catabolic process (GO:0032801)2.83719104
63germinal center formation (GO:0002467)2.82294271
64regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.78718053
65regulation of cardioblast differentiation (GO:0051890)2.76865788
66ventricular cardiac muscle cell action potential (GO:0086005)2.76728321
67actin filament-based movement (GO:0030048)2.76555300
68hemidesmosome assembly (GO:0031581)2.74732147
69heart trabecula formation (GO:0060347)2.74087558
70pyrimidine nucleoside salvage (GO:0043097)2.72535415
71pyrimidine-containing compound salvage (GO:0008655)2.72535415
72cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.72343552
73regulation of response to osmotic stress (GO:0047484)2.72125593
74ensheathment of neurons (GO:0007272)2.70430002
75axon ensheathment (GO:0008366)2.70430002
76regulation of skeletal muscle contraction (GO:0014819)2.69991189
77positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.69847330
78dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.69458983
79positive regulation of receptor recycling (GO:0001921)2.69443816
80myelination (GO:0042552)2.65760796
81cornea development in camera-type eye (GO:0061303)2.65438421
82detection of biotic stimulus (GO:0009595)2.64866080
83negative regulation of keratinocyte proliferation (GO:0010839)2.63782144
84membrane tubulation (GO:0097320)2.63592742
85protein targeting to plasma membrane (GO:0072661)2.62840323
86regulation of leukocyte degranulation (GO:0043300)2.61491413
87bundle of His cell to Purkinje myocyte communication (GO:0086069)2.59922610
88nerve growth factor signaling pathway (GO:0038180)2.59857481
89cortical actin cytoskeleton organization (GO:0030866)2.58676204
90positive regulation of cellular amide metabolic process (GO:0034250)2.58105467
91cardiac muscle cell development (GO:0055013)2.57784700
92multicellular organismal water homeostasis (GO:0050891)2.57686146
93embryonic eye morphogenesis (GO:0048048)2.57553443
94cell-substrate junction assembly (GO:0007044)2.57395976
95sarcoplasmic reticulum calcium ion transport (GO:0070296)2.57318210
96myelin maintenance (GO:0043217)2.56876208
97detection of molecule of bacterial origin (GO:0032490)2.56628609
98regulation of membrane repolarization (GO:0060306)2.55859485
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.55732812
100regulation of anoikis (GO:2000209)2.55471867
101leukocyte aggregation (GO:0070486)2.55428991
102cell communication by electrical coupling (GO:0010644)2.54326678
103regulation of p38MAPK cascade (GO:1900744)2.54294720
104positive regulation of myotube differentiation (GO:0010831)2.54272725
105myelination in peripheral nervous system (GO:0022011)2.54272367
106peripheral nervous system axon ensheathment (GO:0032292)2.54272367
107skin morphogenesis (GO:0043589)2.53547557
108adult heart development (GO:0007512)2.53151845
109negative regulation of interleukin-17 production (GO:0032700)2.52810184
110positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.52589595
111neutrophil mediated immunity (GO:0002446)2.51210200
112response to laminar fluid shear stress (GO:0034616)2.49397723
113regulation of striated muscle contraction (GO:0006942)2.48555247
114glandular epithelial cell development (GO:0002068)2.48140015
115regulation of mast cell degranulation (GO:0043304)2.48039521
116regulation of relaxation of muscle (GO:1901077)2.48016644
117semaphorin-plexin signaling pathway (GO:0071526)2.47729835
118regulation of cell communication by electrical coupling (GO:0010649)2.47135489
119potassium ion import (GO:0010107)2.46809475
120neutrophil activation (GO:0042119)2.45815361
121ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.45753361
122cardiac cell development (GO:0055006)2.45683110
123sodium ion export (GO:0071436)2.45646248
124cardiac muscle tissue morphogenesis (GO:0055008)2.45160793
125pentose-phosphate shunt (GO:0006098)2.44997173
126adherens junction assembly (GO:0034333)2.43759347
127astrocyte differentiation (GO:0048708)2.43736418
128regulation of sarcomere organization (GO:0060297)2.43516343
129regulation of the force of heart contraction (GO:0002026)2.43459580
130epidermis development (GO:0008544)2.43052279
131leukocyte migration involved in inflammatory response (GO:0002523)2.42598855
132cytoplasmic mRNA processing body assembly (GO:0033962)2.42047517
133striated muscle contraction (GO:0006941)2.41279811
134regulation of myeloid leukocyte mediated immunity (GO:0002886)2.40506794
135negative regulation of anoikis (GO:2000811)2.40483978
136renal filtration (GO:0097205)2.39953645
137regulation of B cell receptor signaling pathway (GO:0050855)2.38785665
138glomerular filtration (GO:0003094)2.38373276
139granulocyte activation (GO:0036230)2.37034131
140establishment of nucleus localization (GO:0040023)2.36400993
141mammary gland epithelial cell proliferation (GO:0033598)2.35292084
142epithelial cell-cell adhesion (GO:0090136)2.34960194
143regulation of calcium ion transmembrane transporter activity (GO:1901019)2.34760089
144regulation of calcium ion transmembrane transport (GO:1903169)2.34760089
145neuromuscular junction development (GO:0007528)2.34716485
146import into cell (GO:0098657)2.34086330
147regulation of cardiac muscle cell contraction (GO:0086004)2.34044525
148layer formation in cerebral cortex (GO:0021819)2.31495961
149muscle tissue morphogenesis (GO:0060415)2.31170819
150heparan sulfate proteoglycan metabolic process (GO:0030201)2.30920806
151B cell receptor signaling pathway (GO:0050853)2.29907951
152regulation of ARF GTPase activity (GO:0032312)2.29871792
153positive regulation of epidermal cell differentiation (GO:0045606)2.28733256
154negative regulation of interleukin-8 production (GO:0032717)2.28613292
155positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.28570238
156molting cycle (GO:0042303)2.27944608
157hair cycle (GO:0042633)2.27944608
158membrane raft organization (GO:0031579)2.27091892
159G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.26700486
160antigen processing and presentation of endogenous antigen (GO:0019883)2.26484468
161cell adhesion mediated by integrin (GO:0033627)2.26300337
162negative regulation of T cell mediated immunity (GO:0002710)2.26108955
163cortical cytoskeleton organization (GO:0030865)2.26052138
164response to host (GO:0075136)2.25988335
165response to host defenses (GO:0052200)2.25988335
166response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.25988335
167membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.25309355
168cellular response to osmotic stress (GO:0071470)2.24822385
169response to host immune response (GO:0052572)2.24712954
170response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.24712954
171vascular endothelial growth factor signaling pathway (GO:0038084)2.24447530
172regulation of T-helper 2 cell differentiation (GO:0045628)2.23935936
173negative regulation of homotypic cell-cell adhesion (GO:0034111)2.23401548
174antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.23205654
175negative regulation of catenin import into nucleus (GO:0035414)2.22480956
176positive regulation of mast cell activation (GO:0033005)2.22074203
177peptidyl-tyrosine autophosphorylation (GO:0038083)2.20008419
178lymph vessel development (GO:0001945)2.19377959
179cardiac muscle hypertrophy (GO:0003300)2.18790337
180positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.17121596
181adhesion of symbiont to host cell (GO:0044650)2.17008504
182virion attachment to host cell (GO:0019062)2.17008504
183L-amino acid import (GO:0043092)2.16677007
184glomerular visceral epithelial cell development (GO:0072015)2.16164017
185retina vasculature morphogenesis in camera-type eye (GO:0061299)2.15789456
186camera-type eye morphogenesis (GO:0048593)2.13579238
187atrioventricular valve morphogenesis (GO:0003181)2.13101891
188cell-substrate adherens junction assembly (GO:0007045)2.12965504
189focal adhesion assembly (GO:0048041)2.12965504
190regulation of cardiac muscle contraction (GO:0055117)2.12925691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.23044643
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.81569263
3* MYC_22102868_ChIP-Seq_BL_Human2.40038316
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.35080117
5EP300_21415370_ChIP-Seq_HL-1_Mouse2.33291445
6MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30493327
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20230172
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.15808683
9TCF7_22412390_ChIP-Seq_EML_Mouse2.12012581
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00662739
11VDR_21846776_ChIP-Seq_THP-1_Human1.98095481
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94325640
13RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94256103
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93714204
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.92057121
16VDR_24763502_ChIP-Seq_THP-1_Human1.91990909
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90430585
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.89067525
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.86701680
20DROSHA_22980978_ChIP-Seq_HELA_Human1.83102364
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81203516
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79063951
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79063951
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76837419
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75250844
26* IRF8_27001747_Chip-Seq_BMDM_Mouse1.73534441
27RUNX_20019798_ChIP-Seq_JUKART_Human1.73525308
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72489530
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71524179
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70366256
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.70298195
32* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69662995
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68328792
34TBX20_22328084_ChIP-Seq_HEART_Mouse1.67796019
35TBX20_22080862_ChIP-Seq_HEART_Mouse1.67796019
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66248480
37ZNF263_19887448_ChIP-Seq_K562_Human1.64509429
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64162223
39SPI1_23127762_ChIP-Seq_K562_Human1.63841392
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.63668236
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62718678
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61819841
43EZH2_22144423_ChIP-Seq_EOC_Human1.61471795
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58553359
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.57445681
46SCL_19346495_ChIP-Seq_HPC-7_Human1.55921911
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55669587
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55260886
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.53795563
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52752305
51KDM2B_26808549_Chip-Seq_K562_Human1.52693973
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52623795
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52337877
54MAF_26560356_Chip-Seq_TH1_Human1.51967957
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.49876092
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.48606354
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.48058367
58AR_21572438_ChIP-Seq_LNCaP_Human1.47744490
59* CLOCK_20551151_ChIP-Seq_293T_Human1.46850196
60KDM2B_26808549_Chip-Seq_DND41_Human1.45592801
61* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45554694
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43887482
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.43604002
64* TP53_16413492_ChIP-PET_HCT116_Human1.42383318
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39987812
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39341854
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38995894
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38286148
69UBF1/2_26484160_Chip-Seq_HMECs_Human1.38226749
70CJUN_26792858_Chip-Seq_BT549_Human1.37691547
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.37568662
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37364691
73* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36693607
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36579608
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.36378550
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.35300517
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.34785293
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.34152172
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32491284
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32054505
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30855048
82PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30566317
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29140771
84EZH2_27304074_Chip-Seq_ESCs_Mouse1.28704699
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28419458
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28054170
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26820171
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25337873
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24750771
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.24325910
91* UTX_26944678_Chip-Seq_JUKART_Human1.23893220
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.23605523
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.23034527
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20958499
95AHR_22903824_ChIP-Seq_MCF-7_Human1.19608176
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19445567
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18636735
98VDR_24787735_ChIP-Seq_THP-1_Human1.18150203
99RARB_27405468_Chip-Seq_BRAIN_Mouse1.18015589
100ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15934769
101BP1_19119308_ChIP-ChIP_Hs578T_Human1.14621270
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14301214
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14067955
104EGR1_19032775_ChIP-ChIP_M12_Human1.13746161
105RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13078407
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12790548
107NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12414663
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12414663
109ELK3_25401928_ChIP-Seq_HUVEC_Human1.12337999
110CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09192425
111SPI1_23547873_ChIP-Seq_NB4_Human1.08898423
112ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07915016
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07780405
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07359279
115GATA1_19941826_ChIP-Seq_K562_Human1.05678307
116* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04808386
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03649684
118ISL1_27105846_Chip-Seq_CPCs_Mouse1.03538330
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03403480
120SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03312610
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02955377
122ARNT_22903824_ChIP-Seq_MCF-7_Human1.02289735
123TP53_22127205_ChIP-Seq_IMR90_Human1.02013539
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01921395
125* PU_27001747_Chip-Seq_BMDM_Mouse1.01900956
126NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01486889
127GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01386279
128NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00608299
129GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00426183
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.98927796
131RXR_22108803_ChIP-Seq_LS180_Human0.98143308
132FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97976491
133RACK7_27058665_Chip-Seq_MCF-7_Human0.97716318
134MAF_26560356_Chip-Seq_TH2_Human0.97283487
135TP53_18474530_ChIP-ChIP_U2OS_Human0.97143926
136MYB_26560356_Chip-Seq_TH1_Human0.96599337
137DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96503341
138MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96162425
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95579013
140* RUNX1_27514584_Chip-Seq_MCF-7_Human0.95264344
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94647305
142KLF5_25053715_ChIP-Seq_YYC3_Human0.94633221
143NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93627050
144CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93178344
145GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92650859
146P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92159735
147RING1B_27294783_Chip-Seq_ESCs_Mouse0.91776270
148* TP63_23658742_ChIP-Seq_EP156T_Human0.91678056
149LXR_22292898_ChIP-Seq_THP-1_Human0.91266528
150SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90950532
151SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90950532
152SMAD3_21741376_ChIP-Seq_HESCs_Human0.90094854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005257_abnormal_intraocular_pressure4.47882144
2MP0000751_myopathy3.85510692
3MP0008438_abnormal_cutaneous_collagen3.63347151
4MP0005275_abnormal_skin_tensile3.58064584
5MP0004084_abnormal_cardiac_muscle3.30634757
6MP0002837_dystrophic_cardiac_calcinosis3.15992848
7MP0003705_abnormal_hypodermis_morpholog2.73294130
8MP0005623_abnormal_meninges_morphology2.62181961
9MP0000749_muscle_degeneration2.56590972
10MP0004036_abnormal_muscle_relaxation2.54571884
11MP0004215_abnormal_myocardial_fiber2.39833597
12MP0004381_abnormal_hair_follicle2.36111021
13MP0004087_abnormal_muscle_fiber2.34865133
14MP0003950_abnormal_plasma_membrane2.33451732
15MP0005330_cardiomyopathy2.31978741
16MP0008260_abnormal_autophagy2.29471461
17MP0005409_darkened_coat_color2.14846889
18MP0000750_abnormal_muscle_regeneration2.11076848
19MP0003724_increased_susceptibility_to2.10848601
20MP0000747_muscle_weakness2.02217291
21MP0010234_abnormal_vibrissa_follicle2.00970689
22MP0001216_abnormal_epidermal_layer2.00456370
23MP0004947_skin_inflammation1.99030337
24MP0003566_abnormal_cell_adhesion1.95866970
25MP0005464_abnormal_platelet_physiology1.95683559
26MP0002972_abnormal_cardiac_muscle1.94555963
27MP0003436_decreased_susceptibility_to1.93660537
28MP0004185_abnormal_adipocyte_glucose1.93261757
29MP0004272_abnormal_basement_membrane1.93001982
30MP0003279_aneurysm1.87423366
31MP0004130_abnormal_muscle_cell1.87242503
32MP0000465_gastrointestinal_hemorrhage1.83111848
33MP0000733_abnormal_muscle_development1.81814004
34MP0002796_impaired_skin_barrier1.79822097
35MP0005451_abnormal_body_composition1.79716858
36MP0006138_congestive_heart_failure1.79140557
37MP0010630_abnormal_cardiac_muscle1.78514574
38MP0004859_abnormal_synaptic_plasticity1.78345089
39MP0005620_abnormal_muscle_contractility1.76913603
40MP0008775_abnormal_heart_ventricle1.75275421
41MP0000920_abnormal_myelination1.69605911
42MP0004145_abnormal_muscle_electrophysio1.68159239
43MP0003191_abnormal_cellular_cholesterol1.66781903
44MP0002106_abnormal_muscle_physiology1.66453689
45MP0000759_abnormal_skeletal_muscle1.64850559
46MP0003646_muscle_fatigue1.61851855
47MP0003941_abnormal_skin_development1.60805322
48MP0004270_analgesia1.60233258
49MP0002098_abnormal_vibrissa_morphology1.60152346
50MP0003137_abnormal_impulse_conducting1.57325693
51MP0001958_emphysema1.56988097
52MP0004510_myositis1.54265157
53MP0003329_amyloid_beta_deposits1.52744908
54MP0001849_ear_inflammation1.50378492
55MP0009278_abnormal_bone_marrow1.50165507
56MP0001544_abnormal_cardiovascular_syste1.47269465
57MP0005385_cardiovascular_system_phenoty1.47269465
58MP0003763_abnormal_thymus_physiology1.45593649
59MP0006292_abnormal_olfactory_placode1.45286462
60MP0005369_muscle_phenotype1.45053947
61MP0000377_abnormal_hair_follicle1.44204685
62MP0005666_abnormal_adipose_tissue1.42068077
63MP0005375_adipose_tissue_phenotype1.42023953
64MP0000003_abnormal_adipose_tissue1.40646747
65MP0004484_altered_response_of1.39738707
66MP0001835_abnormal_antigen_presentation1.35819519
67MP0009053_abnormal_anal_canal1.35001970
68MP0004085_abnormal_heartbeat1.32975403
69MP0003091_abnormal_cell_migration1.32503732
70MP0002419_abnormal_innate_immunity1.30505228
71MP0000013_abnormal_adipose_tissue1.30458910
72MP0002269_muscular_atrophy1.30361039
73MP0010368_abnormal_lymphatic_system1.29574615
74MP0003828_pulmonary_edema1.27017998
75MP0005503_abnormal_tendon_morphology1.24975625
76MP0001299_abnormal_eye_distance/1.24600503
77MP0010678_abnormal_skin_adnexa1.23527369
78MP0002060_abnormal_skin_morphology1.23457360
79MP0009780_abnormal_chondrocyte_physiolo1.22944615
80MP0005000_abnormal_immune_tolerance1.21079504
81MP0003690_abnormal_glial_cell1.20897734
82MP0000685_abnormal_immune_system1.19825028
83MP0010352_gastrointestinal_tract_polyps1.18186310
84MP0002234_abnormal_pharynx_morphology1.17463964
85MP0000762_abnormal_tongue_morphology1.16771582
86MP0000858_altered_metastatic_potential1.16689460
87MP0002108_abnormal_muscle_morphology1.15952322
88MP0003045_fibrosis1.15723353
89MP0004808_abnormal_hematopoietic_stem1.09776946
90MP0008789_abnormal_olfactory_epithelium1.09123696
91MP0005025_abnormal_response_to1.07995158
92MP0009931_abnormal_skin_appearance1.07099747
93MP0002998_abnormal_bone_remodeling1.06178144
94MP0001879_abnormal_lymphatic_vessel1.05260290
95MP0003303_peritoneal_inflammation1.05124930
96MP0004233_abnormal_muscle_weight1.04948697
97MP0001533_abnormal_skeleton_physiology1.04169110
98MP0002452_abnormal_antigen_presenting1.04110573
99MP0005076_abnormal_cell_differentiation1.04050418
100MP0000579_abnormal_nail_morphology1.04033554
101MP0000767_abnormal_smooth_muscle1.02830517
102MP0000015_abnormal_ear_pigmentation0.99882522
103MP0000428_abnormal_craniofacial_morphol0.99647059
104MP0001790_abnormal_immune_system0.99579274
105MP0005387_immune_system_phenotype0.99579274
106MP0005501_abnormal_skin_physiology0.98970753
107MP0003300_gastrointestinal_ulcer0.98863982
108MP0002420_abnormal_adaptive_immunity0.98863202
109MP0005499_abnormal_olfactory_system0.97948696
110MP0005394_taste/olfaction_phenotype0.97948696
111MP0002009_preneoplasia0.97802750
112MP0000569_abnormal_digit_pigmentation0.97661966
113MP0001800_abnormal_humoral_immune0.97057926
114MP0008004_abnormal_stomach_pH0.96827411
115MP0001819_abnormal_immune_cell0.96701312
116MP0003634_abnormal_glial_cell0.96253401
117MP0002295_abnormal_pulmonary_circulatio0.95962943
118MP0009384_cardiac_valve_regurgitation0.94873010
119MP0002396_abnormal_hematopoietic_system0.94338617
120MP0004858_abnormal_nervous_system0.93884296
121MP0002723_abnormal_immune_serum0.93473137
122MP0002638_abnormal_pupillary_reflex0.92993444
123MP0000383_abnormal_hair_follicle0.88609641
124MP0003172_abnormal_lysosome_physiology0.87914892
125MP0003453_abnormal_keratinocyte_physiol0.85315990
126MP0010771_integument_phenotype0.83417274
127MP0002128_abnormal_blood_circulation0.83134588
128MP0002398_abnormal_bone_marrow0.81507696
129MP0003448_altered_tumor_morphology0.81064055
130MP0001545_abnormal_hematopoietic_system0.79257031
131MP0005397_hematopoietic_system_phenotyp0.79257031
132MP0003787_abnormal_imprinting0.79099779
133MP0005023_abnormal_wound_healing0.78549738
134MP0008569_lethality_at_weaning0.77759370
135MP0005670_abnormal_white_adipose0.77731139
136MP0000604_amyloidosis0.77380331
137MP0003385_abnormal_body_wall0.77290852
138MP0003635_abnormal_synaptic_transmissio0.76452306
139MP0001851_eye_inflammation0.76383798
140MP0002089_abnormal_postnatal_growth/wei0.75440372
141MP0000266_abnormal_heart_morphology0.75297426
142MP0001348_abnormal_lacrimal_gland0.75249879
143MP0002971_abnormal_brown_adipose0.74932145
144MP0000467_abnormal_esophagus_morphology0.74414450
145MP0004883_abnormal_blood_vessel0.74170672
146MP0005167_abnormal_blood-brain_barrier0.73974109
147MP0002405_respiratory_system_inflammati0.72539147
148MP0000716_abnormal_immune_system0.72518715
149MP0010155_abnormal_intestine_physiology0.72350213
150MP0000367_abnormal_coat/_hair0.72037573
151MP0005621_abnormal_cell_physiology0.71923053
152MP0005058_abnormal_lysosome_morphology0.71805556
153MP0003221_abnormal_cardiomyocyte_apopto0.71538107
154MP0002177_abnormal_outer_ear0.71332442
155MP0002896_abnormal_bone_mineralization0.70585978
156MP0002133_abnormal_respiratory_system0.70585786
157MP0005388_respiratory_system_phenotype0.70585786
158MP0005165_increased_susceptibility_to0.68077605
159MP0001784_abnormal_fluid_regulation0.67676249
160MP0002925_abnormal_cardiovascular_devel0.67260690
161MP0006054_spinal_hemorrhage0.66600459
162MP0002877_abnormal_melanocyte_morpholog0.64918593
163MP0002090_abnormal_vision0.64778882
164MP0000647_abnormal_sebaceous_gland0.64766631
165MP0004885_abnormal_endolymph0.64359141

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)5.37226817
2Thick nail (HP:0001805)5.28086042
3Hyporeflexia of lower limbs (HP:0002600)4.89650247
4Sudden death (HP:0001699)4.69145800
5Muscle fiber splitting (HP:0003555)4.61548178
6Milia (HP:0001056)4.27787281
7Plantar hyperkeratosis (HP:0007556)4.15717597
8Right ventricular cardiomyopathy (HP:0011663)4.00355021
9Increased IgE level (HP:0003212)3.95458812
10Onycholysis (HP:0001806)3.94699611
11Ventricular tachycardia (HP:0004756)3.88153008
12Palmoplantar hyperkeratosis (HP:0000972)3.79063096
13Premature rupture of membranes (HP:0001788)3.77694752
14Increased connective tissue (HP:0009025)3.61515402
15* Difficulty running (HP:0009046)3.61061313
16Abnormality of the calf musculature (HP:0001430)3.60063026
17Palmar hyperkeratosis (HP:0010765)3.52581122
18Alopecia of scalp (HP:0002293)3.52104093
19Eczematoid dermatitis (HP:0000976)3.47277726
20Fragile nails (HP:0001808)3.42640025
21Calf muscle hypertrophy (HP:0008981)3.29906057
22Exercise-induced myalgia (HP:0003738)3.28533770
23Distal lower limb muscle weakness (HP:0009053)3.26388426
24Atrial fibrillation (HP:0005110)3.24969364
25Type 1 muscle fiber predominance (HP:0003803)3.22430000
26Muscle hypertrophy of the lower extremities (HP:0008968)3.17987401
27Increased variability in muscle fiber diameter (HP:0003557)3.15708579
28EMG: myopathic abnormalities (HP:0003458)3.12246705
29Nail dystrophy (HP:0008404)3.08165484
30Obstructive sleep apnea (HP:0002870)3.06892666
31Cerebral aneurysm (HP:0004944)3.06867739
32Difficulty climbing stairs (HP:0003551)3.05203045
33Primary atrial arrhythmia (HP:0001692)3.04897491
34Exercise-induced muscle cramps (HP:0003710)3.03676227
35Broad metatarsal (HP:0001783)2.96967367
36Protrusio acetabuli (HP:0003179)2.93245908
37Shallow orbits (HP:0000586)2.92938083
38Supraventricular arrhythmia (HP:0005115)2.86670906
39Recurrent bacterial skin infections (HP:0005406)2.84471598
40Supraventricular tachycardia (HP:0004755)2.84428574
41Abnormality of skeletal muscle fiber size (HP:0012084)2.81408943
42* Scapular winging (HP:0003691)2.76297480
43Lower limb amyotrophy (HP:0007210)2.71945240
44Termporal pattern (HP:0011008)2.71271689
45Insidious onset (HP:0003587)2.71271689
46Lipoatrophy (HP:0100578)2.70316707
47Distal lower limb amyotrophy (HP:0008944)2.65139737
48Bundle branch block (HP:0011710)2.63952744
49Neurofibrillary tangles (HP:0002185)2.63057883
50Abnormal platelet volume (HP:0011876)2.61441274
51Prolonged bleeding time (HP:0003010)2.59846031
52Round ear (HP:0100830)2.58137176
53Ridged nail (HP:0001807)2.54552708
54Syncope (HP:0001279)2.53911877
55Abnormal blistering of the skin (HP:0008066)2.52398815
56Prolonged QT interval (HP:0001657)2.51655516
57Cerebral inclusion bodies (HP:0100314)2.50457081
58Aortic dissection (HP:0002647)2.49170944
59Mildly elevated creatine phosphokinase (HP:0008180)2.44290173
60Hypotrichosis (HP:0001006)2.43747030
61Foot dorsiflexor weakness (HP:0009027)2.43058062
62Subaortic stenosis (HP:0001682)2.41850518
63Abnormality of the left ventricular outflow tract (HP:0011103)2.41850518
64Increased mean platelet volume (HP:0011877)2.41378269
65Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.39934417
66Abnormality of the foot musculature (HP:0001436)2.36929175
67Atrophic scars (HP:0001075)2.35334912
68Erythema (HP:0010783)2.33988728
69* Gowers sign (HP:0003391)2.32530525
70Abnormality of the distal phalanges of the toes (HP:0010182)2.32131896
71Ventricular arrhythmia (HP:0004308)2.32045057
72Flat acetabular roof (HP:0003180)2.31646103
73Spinal rigidity (HP:0003306)2.28703024
74Sparse scalp hair (HP:0002209)2.26331060
75Muscle fiber inclusion bodies (HP:0100299)2.26242218
76Myotonia (HP:0002486)2.25616231
77Pustule (HP:0200039)2.25208317
78Onion bulb formation (HP:0003383)2.22913501
79Ventricular fibrillation (HP:0001663)2.22622738
80Asymmetric septal hypertrophy (HP:0001670)2.22056107
81Rapidly progressive (HP:0003678)2.22035971
82Dilated cardiomyopathy (HP:0001644)2.21239811
83Recurrent abscess formation (HP:0002722)2.19187968
84Spontaneous hematomas (HP:0007420)2.17837166
85Degeneration of the lateral corticospinal tracts (HP:0002314)2.17101707
86Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17101707
87Natal tooth (HP:0000695)2.16357248
88Abnormality of the axillary hair (HP:0100134)2.16279149
89Abnormality of secondary sexual hair (HP:0009888)2.16279149
90Ankyloglossia (HP:0010296)2.12990503
91Aortic aneurysm (HP:0004942)2.12685739
92Hypoplasia of the fovea (HP:0007750)2.09298914
93Aplasia/Hypoplasia of the fovea (HP:0008060)2.09298914
94Fragile skin (HP:0001030)2.08933137
95Abnormality of macrophages (HP:0004311)2.08170007
96Abnormal atrioventricular conduction (HP:0005150)2.07336779
97Cellulitis (HP:0100658)2.04478655
98Upper limb amyotrophy (HP:0009129)2.03744034
99Distal upper limb amyotrophy (HP:0007149)2.03744034
100Erythroderma (HP:0001019)2.02478061
101Broad face (HP:0000283)2.00938971
102Ankle contracture (HP:0006466)2.00325110
103Spinal muscular atrophy (HP:0007269)1.99938570
104Arterial tortuosity (HP:0005116)1.99893131
105Bladder diverticulum (HP:0000015)1.99248107
106Mitral valve prolapse (HP:0001634)1.98948781
107Supranuclear gaze palsy (HP:0000605)1.98648372
108Atrioventricular block (HP:0001678)1.97089591
109Menorrhagia (HP:0000132)1.96384794
110Heart block (HP:0012722)1.95292321
111Vascular tortuosity (HP:0004948)1.94522498
112Dysmetric saccades (HP:0000641)1.93737819
113Hypoplastic ischia (HP:0003175)1.93490503
114Spondylolisthesis (HP:0003302)1.93049462
115Selective tooth agenesis (HP:0001592)1.92942472
116Advanced eruption of teeth (HP:0006288)1.92880302
117Abnormal vertebral ossification (HP:0100569)1.92649038
118Buphthalmos (HP:0000557)1.92283067
119Abnormality of the salivary glands (HP:0010286)1.92092190
120Neck muscle weakness (HP:0000467)1.91963286
121Hand muscle atrophy (HP:0009130)1.90898601
122Abnormality of oral frenula (HP:0000190)1.90694640
123Action tremor (HP:0002345)1.90693653
124Hammertoe (HP:0001765)1.89969283
125Skin ulcer (HP:0200042)1.89595511
126Epistaxis (HP:0000421)1.89103088
127Infantile muscular hypotonia (HP:0008947)1.88644859
128Hypoplasia of the iris (HP:0007676)1.87222648
129Aplasia involving bones of the upper limbs (HP:0009823)1.85878702
130Aplasia of the phalanges of the hand (HP:0009802)1.85878702
131Aplasia involving bones of the extremities (HP:0009825)1.85878702
132Akinesia (HP:0002304)1.85732243
133Corneal erosion (HP:0200020)1.85513012
134Limb-girdle muscle atrophy (HP:0003797)1.85083290
135Disproportionate tall stature (HP:0001519)1.84249925
136Xerostomia (HP:0000217)1.83962514
137Myoglobinuria (HP:0002913)1.82345845
138Urticaria (HP:0001025)1.82103937
139Peritonitis (HP:0002586)1.81333062
140Woolly hair (HP:0002224)1.80233447
141Aplasia cutis congenita (HP:0001057)1.80125001
142Dilatation of the ascending aorta (HP:0005111)1.79878238
143Gingivitis (HP:0000230)1.79057483
144Abnormality of the corticospinal tract (HP:0002492)1.78434789
145Aplasia/Hypoplasia of the macula (HP:0008059)1.78309283
146Follicular hyperkeratosis (HP:0007502)1.78298744
147Pili torti (HP:0003777)1.78189709
148Aneurysm (HP:0002617)1.76908961
149Oral leukoplakia (HP:0002745)1.76848619
150Laryngomalacia (HP:0001601)1.76409790
151Gingival bleeding (HP:0000225)1.76217093
152Overgrowth (HP:0001548)1.75583062
153Nemaline bodies (HP:0003798)1.75500532
154Hamartoma of the eye (HP:0010568)1.75203204
155Sudden cardiac death (HP:0001645)1.75120712
156Corneal dystrophy (HP:0001131)1.73944808
157Spinal cord compression (HP:0002176)1.73046883
158Fatigable weakness (HP:0003473)1.72914870
159Abnormality of the neuromuscular junction (HP:0003398)1.72914870
160Fetal akinesia sequence (HP:0001989)1.71155600
161Hyperacusis (HP:0010780)1.70923384
162Stridor (HP:0010307)1.70237333
163Keratitis (HP:0000491)1.68872310
164EMG: neuropathic changes (HP:0003445)1.68530426
165Pterygium (HP:0001059)1.68055034
166Abnormality of the ischium (HP:0003174)1.67557336
167Wormian bones (HP:0002645)1.67470272
168Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.66715742
169Palmoplantar keratoderma (HP:0000982)1.66063553
170Congenital ichthyosiform erythroderma (HP:0007431)1.65924593
171Abnormality of carpal bone ossification (HP:0006257)1.65447325
172Osteolytic defects of the hand bones (HP:0009699)1.65323927
173Osteolytic defects of the phalanges of the hand (HP:0009771)1.65323927
174Recurrent skin infections (HP:0001581)1.65209106
175Diaphragmatic weakness (HP:0009113)1.64544956
176Generalized hyperpigmentation (HP:0007440)1.64000947
177Abnormal ossification of hand bones (HP:0005921)1.63971559
178Ectropion (HP:0000656)1.63627751
179Subacute progressive viral hepatitis (HP:0006572)1.63533743
180Papillary thyroid carcinoma (HP:0002895)1.62583831
181Lip pit (HP:0100267)1.61704836
182Keratoconjunctivitis sicca (HP:0001097)1.60215734
183Aplasia/Hypoplasia affecting the retina (HP:0008061)1.59037360
184Hypoplasia of dental enamel (HP:0006297)1.56670378
185Cheilitis (HP:0100825)1.54439642
186Persistence of primary teeth (HP:0006335)1.50960891
187Genu recurvatum (HP:0002816)1.49667170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.09672209
2TRIB33.92719172
3PRPF4B3.06933728
4EPHB12.79245497
5DMPK2.62666506
6RIPK42.49498867
7PKN22.28646708
8STK392.14416389
9BLK2.08871811
10FES2.03673410
11HIPK21.98508319
12MAP3K131.94487672
13PHKG11.94431379
14PHKG21.94431379
15TAOK21.84456670
16IRAK21.82692265
17RIPK11.79164033
18MAP3K61.73148134
19ERN11.72065829
20PAK61.67967445
21LMTK21.67259212
22PAK31.66555774
23CDK121.64961331
24MAP2K31.62652444
25PDGFRA1.58143229
26CSK1.53694630
27WNK11.52813630
28STK241.45400643
29NTRK11.44753907
30DDR21.41747103
31MAP4K11.41270769
32PKN11.39865149
33PRKD11.39009163
34LATS11.37306466
35TRPM71.36763903
36HCK1.35350939
37EPHB21.33973622
38SGK31.33645636
39ICK1.31327042
40LATS21.30673420
41ROCK21.30313000
42MAP3K11.28807343
43CSF1R1.28693883
44BTK1.25265479
45TIE11.25195784
46MUSK1.23584565
47CAMK1G1.23172788
48MAP3K31.23154781
49OBSCN1.22917008
50PTK61.17153374
51TYRO31.16490106
52JAK31.15570912
53FER1.15009621
54PIK3CA1.14291548
55KSR21.13125860
56IRAK41.12962017
57SMG11.11678189
58ARAF1.11066110
59ZAP701.09469053
60ILK1.09070796
61BMX1.08038143
62ROCK11.07963562
63RET1.07610729
64MAP3K141.06515683
65PRKD31.05758121
66PTK2B1.05301607
67SGK21.05157803
68PRKCH1.04502702
69RPS6KA21.04264063
70PAK21.03860915
71PDGFRB1.03243227
72MAPK71.03225591
73IRAK31.02792994
74FGFR21.02467520
75MAP3K101.01674093
76TGFBR21.01610671
77PIK3CG1.00058452
78MET0.99706983
79MAP3K90.99206718
80GRK60.98922224
81PTK20.97910763
82MOS0.95316938
83MARK20.95164949
84TYK20.94355141
85CAMK1D0.93411323
86MYLK0.92774671
87MAP3K70.91859172
88CLK10.91355015
89WNK40.89305201
90EEF2K0.89199082
91KSR10.88420382
92SIK10.88323702
93PDPK10.86602672
94LRRK20.85309203
95IRAK10.83891266
96FGR0.83060975
97MAPK120.82430653
98MAPKAPK50.82400085
99LIMK10.82045444
100TGFBR10.81974120
101STK100.81080774
102SYK0.79437928
103NEK90.79104755
104TAOK10.77656655
105YES10.77656548
106CAMK2D0.76371078
107CDC42BPA0.75771827
108OXSR10.74159929
109PDK40.72963295
110PDK30.72963295
111CDK50.72925571
112RPS6KL10.72112633
113RPS6KC10.72112633
114RAF10.72080178
115MARK10.71514464
116MAP3K80.71029066
117SGK2230.69451192
118SGK4940.69451192
119SIK20.69175525
120ALK0.68351586
121LYN0.66746574
122MTOR0.64757661
123EPHA40.64123832
124CDK60.62870237
125STK110.60682681
126STK380.60474329
127CAMKK10.58870647
128NTRK20.57251039
129MAPKAPK30.56764707
130PDK10.55900963
131JAK20.53946289
132MAP2K10.53818773
133CAMK2A0.53422195
134FYN0.52895283
135JAK10.52435742
136BRD40.51984697
137MAP3K20.51885676
138PRKD20.51010319
139PDK20.51000160
140CDK140.50592084
141FGFR30.50561755
142MAP3K50.50135356
143CDK150.49628258
144LCK0.48695765
145DAPK30.48532308
146UHMK10.47757755
147SRC0.43309971
148FGFR10.42649262
149CSNK1A1L0.41701166
150GSK3A0.41288129
151PRKCE0.41080361
152CDK180.40882544
153CDK11A0.39823240
154PRKCQ0.38245653
155SGK10.37846710
156CSNK1D0.36311623

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054142.71217815
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.43328686
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.23025549
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.78782688
5Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.77888308
6ECM-receptor interaction_Homo sapiens_hsa045121.75375626
7Focal adhesion_Homo sapiens_hsa045101.73561890
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73078787
9Cardiac muscle contraction_Homo sapiens_hsa042601.58166457
10Acute myeloid leukemia_Homo sapiens_hsa052211.55313761
11Axon guidance_Homo sapiens_hsa043601.49733675
12Leishmaniasis_Homo sapiens_hsa051401.46178814
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42813721
14Notch signaling pathway_Homo sapiens_hsa043301.40899872
15Renal cell carcinoma_Homo sapiens_hsa052111.40191871
16Dorso-ventral axis formation_Homo sapiens_hsa043201.39675427
17Pentose phosphate pathway_Homo sapiens_hsa000301.33208840
18Gastric acid secretion_Homo sapiens_hsa049711.31545461
19Proteoglycans in cancer_Homo sapiens_hsa052051.30692095
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28763443
21Oxytocin signaling pathway_Homo sapiens_hsa049211.26900449
22Viral myocarditis_Homo sapiens_hsa054161.26762871
23Tight junction_Homo sapiens_hsa045301.24006022
24Tuberculosis_Homo sapiens_hsa051521.23480509
25Other glycan degradation_Homo sapiens_hsa005111.22852443
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18901434
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18732098
28Amoebiasis_Homo sapiens_hsa051461.17181935
29Malaria_Homo sapiens_hsa051441.16632059
30Hematopoietic cell lineage_Homo sapiens_hsa046401.16233691
31Measles_Homo sapiens_hsa051621.16120350
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15428054
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15186961
34Renin secretion_Homo sapiens_hsa049241.15162029
35VEGF signaling pathway_Homo sapiens_hsa043701.14108367
36Glioma_Homo sapiens_hsa052141.12721526
37Influenza A_Homo sapiens_hsa051641.12477693
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.12105525
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.12023037
40Circadian entrainment_Homo sapiens_hsa047131.11283405
41Salivary secretion_Homo sapiens_hsa049701.09992813
42Estrogen signaling pathway_Homo sapiens_hsa049151.09287916
43GnRH signaling pathway_Homo sapiens_hsa049121.08991299
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06552590
45T cell receptor signaling pathway_Homo sapiens_hsa046601.06389990
46Adherens junction_Homo sapiens_hsa045201.05276401
47Gap junction_Homo sapiens_hsa045401.03697683
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.03153819
49Hepatitis B_Homo sapiens_hsa051611.02833882
50Platelet activation_Homo sapiens_hsa046111.02728102
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02646996
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02562314
53Cholinergic synapse_Homo sapiens_hsa047251.02181382
54Inositol phosphate metabolism_Homo sapiens_hsa005621.02172422
55Shigellosis_Homo sapiens_hsa051311.01806041
56Staphylococcus aureus infection_Homo sapiens_hsa051501.01359209
57Thyroid cancer_Homo sapiens_hsa052161.01265928
58Endocytosis_Homo sapiens_hsa041440.98512269
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.98459278
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97628740
61Glutamatergic synapse_Homo sapiens_hsa047240.97511337
62Chronic myeloid leukemia_Homo sapiens_hsa052200.97478805
63ErbB signaling pathway_Homo sapiens_hsa040120.97203409
64Bladder cancer_Homo sapiens_hsa052190.96838523
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96672923
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96211064
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96040165
68Apoptosis_Homo sapiens_hsa042100.96030109
69cAMP signaling pathway_Homo sapiens_hsa040240.95527262
70Rap1 signaling pathway_Homo sapiens_hsa040150.94093059
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94088481
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.93238907
73Phagosome_Homo sapiens_hsa041450.90900861
74Fatty acid biosynthesis_Homo sapiens_hsa000610.90735512
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88871833
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88589608
77Fatty acid elongation_Homo sapiens_hsa000620.86310593
78TNF signaling pathway_Homo sapiens_hsa046680.85981357
79Prostate cancer_Homo sapiens_hsa052150.85404820
80Prolactin signaling pathway_Homo sapiens_hsa049170.85066290
81Colorectal cancer_Homo sapiens_hsa052100.84998712
82Ras signaling pathway_Homo sapiens_hsa040140.84288665
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.84171088
84Long-term potentiation_Homo sapiens_hsa047200.83187290
85FoxO signaling pathway_Homo sapiens_hsa040680.83028265
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.82981715
87Insulin resistance_Homo sapiens_hsa049310.81536577
88Long-term depression_Homo sapiens_hsa047300.81289064
89GABAergic synapse_Homo sapiens_hsa047270.81140823
90Nitrogen metabolism_Homo sapiens_hsa009100.81123198
91Hepatitis C_Homo sapiens_hsa051600.81033893
92Type II diabetes mellitus_Homo sapiens_hsa049300.80671124
93Pancreatic cancer_Homo sapiens_hsa052120.78847220
94Dopaminergic synapse_Homo sapiens_hsa047280.78237129
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78199995
96Melanogenesis_Homo sapiens_hsa049160.77721458
97MAPK signaling pathway_Homo sapiens_hsa040100.77381015
98Calcium signaling pathway_Homo sapiens_hsa040200.76595425
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76421765
100Morphine addiction_Homo sapiens_hsa050320.75636261
101Fatty acid metabolism_Homo sapiens_hsa012120.75172838
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.75156901
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75131305
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.73657106
105AMPK signaling pathway_Homo sapiens_hsa041520.73249098
106Small cell lung cancer_Homo sapiens_hsa052220.72378117
107MicroRNAs in cancer_Homo sapiens_hsa052060.72099001
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72077278
109Olfactory transduction_Homo sapiens_hsa047400.71635383
110Cocaine addiction_Homo sapiens_hsa050300.70307615
111Pathways in cancer_Homo sapiens_hsa052000.69809417
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69614332
113Endometrial cancer_Homo sapiens_hsa052130.69574565
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69330285
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69307919
116Insulin signaling pathway_Homo sapiens_hsa049100.68671481
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68135661
118Hippo signaling pathway_Homo sapiens_hsa043900.66928085
119Choline metabolism in cancer_Homo sapiens_hsa052310.65682346
120Non-small cell lung cancer_Homo sapiens_hsa052230.64931145
121Salmonella infection_Homo sapiens_hsa051320.63769866
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63688305
123Viral carcinogenesis_Homo sapiens_hsa052030.63641660
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63589081
125Herpes simplex infection_Homo sapiens_hsa051680.63059752
126Toxoplasmosis_Homo sapiens_hsa051450.63017231
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59274869
128Legionellosis_Homo sapiens_hsa051340.59229775
129HIF-1 signaling pathway_Homo sapiens_hsa040660.58724970
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58675372
131HTLV-I infection_Homo sapiens_hsa051660.58653739
132mTOR signaling pathway_Homo sapiens_hsa041500.58374949
133Serotonergic synapse_Homo sapiens_hsa047260.57297473
134Osteoclast differentiation_Homo sapiens_hsa043800.56817236
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56386238
136Chemokine signaling pathway_Homo sapiens_hsa040620.56329015
137Insulin secretion_Homo sapiens_hsa049110.56219163
1382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56187208
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55394675
140Pancreatic secretion_Homo sapiens_hsa049720.55155608
141B cell receptor signaling pathway_Homo sapiens_hsa046620.54594861
142Ether lipid metabolism_Homo sapiens_hsa005650.54329311
143Ovarian steroidogenesis_Homo sapiens_hsa049130.53837068

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