BICDL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activated T cell proliferation (GO:0050798)5.65442493
2tolerance induction (GO:0002507)5.11741757
3negative T cell selection (GO:0043383)5.07640503
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.80072830
5negative thymic T cell selection (GO:0045060)4.74107306
6regulation of isotype switching to IgG isotypes (GO:0048302)4.62889803
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.49739286
8negative regulation of cell killing (GO:0031342)4.49739286
9cellular response to interleukin-15 (GO:0071350)4.28150272
10thymic T cell selection (GO:0045061)4.20715282
11regulation of gamma-delta T cell differentiation (GO:0045586)4.11428165
12positive T cell selection (GO:0043368)4.09941164
13response to interleukin-15 (GO:0070672)4.01881597
14behavioral response to nicotine (GO:0035095)3.94234049
15T cell selection (GO:0045058)3.87565052
16regulation of B cell receptor signaling pathway (GO:0050855)3.87461443
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.62047915
18CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.58311253
19positive regulation of gamma-delta T cell activation (GO:0046645)3.50408558
20leukocyte aggregation (GO:0070486)3.50327970
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.44926728
22positive thymic T cell selection (GO:0045059)3.42641838
23regulation of gamma-delta T cell activation (GO:0046643)3.42536574
24negative regulation of T cell mediated immunity (GO:0002710)3.42076351
25regulation of natural killer cell mediated immunity (GO:0002715)3.40906866
26regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.40906866
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33292365
28adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.28284511
29interferon-gamma production (GO:0032609)3.25185957
30positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.23924821
31positive regulation of natural killer cell mediated immunity (GO:0002717)3.23032574
32DNA deamination (GO:0045006)3.16239894
33regulation of regulatory T cell differentiation (GO:0045589)3.12173284
34positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.11673396
35positive regulation of CREB transcription factor activity (GO:0032793)3.10918471
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.08416705
37positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.08267812
38negative regulation of lymphocyte mediated immunity (GO:0002707)3.05192175
39piRNA metabolic process (GO:0034587)3.01360067
40positive regulation of T cell differentiation in thymus (GO:0033089)2.99813477
41alpha-beta T cell differentiation (GO:0046632)2.99558526
42regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.99455858
43antigen processing and presentation of endogenous antigen (GO:0019883)2.98312048
44regulation of leukocyte mediated cytotoxicity (GO:0001910)2.98127965
45NIK/NF-kappaB signaling (GO:0038061)2.94575724
46regulation of T cell mediated cytotoxicity (GO:0001914)2.93624497
47positive regulation of cell killing (GO:0031343)2.92485663
48transmission of nerve impulse (GO:0019226)2.92387876
49regulation of cell killing (GO:0031341)2.83390794
50positive regulation of T cell mediated cytotoxicity (GO:0001916)2.82704549
51DNA methylation involved in gamete generation (GO:0043046)2.82602189
52gamma-aminobutyric acid transport (GO:0015812)2.80373753
53regulation of T cell receptor signaling pathway (GO:0050856)2.74094647
54negative regulation of cAMP-mediated signaling (GO:0043951)2.73240057
55regulation of interleukin-2 biosynthetic process (GO:0045076)2.73232078
56L-fucose catabolic process (GO:0042355)2.73225178
57fucose catabolic process (GO:0019317)2.73225178
58L-fucose metabolic process (GO:0042354)2.73225178
59cerebellar Purkinje cell differentiation (GO:0021702)2.70727028
60positive regulation of interleukin-4 production (GO:0032753)2.69970706
61T cell receptor signaling pathway (GO:0050852)2.68036538
62negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.65057460
63mast cell degranulation (GO:0043303)2.62544660
64mast cell activation involved in immune response (GO:0002279)2.62544660
65regulation of T cell differentiation in thymus (GO:0033081)2.62074820
66positive regulation of granulocyte differentiation (GO:0030854)2.62050733
67T cell homeostasis (GO:0043029)2.61382479
68regulation of alpha-beta T cell proliferation (GO:0046640)2.59183167
69primary amino compound metabolic process (GO:1901160)2.58119563
70negative regulation of B cell mediated immunity (GO:0002713)2.56992142
71negative regulation of immunoglobulin mediated immune response (GO:0002890)2.56992142
72regulation of interleukin-4 production (GO:0032673)2.56912196
73CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.56142590
74T-helper cell differentiation (GO:0042093)2.56142590
75mucosal-associated lymphoid tissue development (GO:0048537)2.54935213
76Peyers patch development (GO:0048541)2.54935213
77CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.53887457
78T cell differentiation involved in immune response (GO:0002292)2.51456151
79alpha-beta T cell differentiation involved in immune response (GO:0002293)2.51456151
80alpha-beta T cell activation involved in immune response (GO:0002287)2.51456151
81mast cell activation (GO:0045576)2.50151025
82antigen receptor-mediated signaling pathway (GO:0050851)2.49937300
83regulation of T cell tolerance induction (GO:0002664)2.49468401
84alpha-beta T cell activation (GO:0046631)2.48908532
85positive regulation of calcium-mediated signaling (GO:0050850)2.44093379
86negative regulation of leukocyte mediated immunity (GO:0002704)2.44051822
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.42702852
88negative regulation of adaptive immune response (GO:0002820)2.41574937
89positive regulation of alpha-beta T cell proliferation (GO:0046641)2.38518130
90T cell differentiation (GO:0030217)2.37268336
91regulation of chronic inflammatory response (GO:0002676)2.36784159
92regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.35631733
93pyrimidine nucleobase catabolic process (GO:0006208)2.35606666
94positive regulation of defense response to virus by host (GO:0002230)2.34834295
95positive regulation of Rap GTPase activity (GO:0032854)2.34831992
96neurotransmitter secretion (GO:0007269)2.34741513
97T cell mediated immunity (GO:0002456)2.29525152
98T cell migration (GO:0072678)2.28709493
99positive regulation of protein homooligomerization (GO:0032464)2.28207636
100ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.27868890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.44386328
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.40281993
3DROSHA_22980978_ChIP-Seq_HELA_Human2.57829024
4REST_21632747_ChIP-Seq_MESCs_Mouse2.50256355
5NOTCH1_21737748_ChIP-Seq_TLL_Human2.49373248
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.45589275
7RUNX_20019798_ChIP-Seq_JUKART_Human2.28625505
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.19785463
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.09846644
10REST_18959480_ChIP-ChIP_MESCs_Mouse2.01540341
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93850026
12ZNF274_21170338_ChIP-Seq_K562_Hela1.93547475
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.87719042
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75872062
15EZH2_27294783_Chip-Seq_ESCs_Mouse1.74489214
16IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73302765
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72437938
18SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63311412
19RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.61970557
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58029472
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47961442
22CTCF_27219007_Chip-Seq_Bcells_Human1.47932411
23MAF_26560356_Chip-Seq_TH2_Human1.47765774
24P68_20966046_ChIP-Seq_HELA_Human1.46528118
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.45586489
26ERA_21632823_ChIP-Seq_H3396_Human1.45277623
27RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41719681
28OCT4_19829295_ChIP-Seq_ESCs_Human1.39211442
29GATA3_27048872_Chip-Seq_THYMUS_Human1.37978418
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37247166
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37207048
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36394068
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35372290
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35272352
35MYB_26560356_Chip-Seq_TH2_Human1.34838302
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34677716
37E2F1_20622854_ChIP-Seq_HELA_Human1.32038066
38RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.29951704
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.29886327
40MYC_22102868_ChIP-Seq_BL_Human1.27062408
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.25859232
42VDR_22108803_ChIP-Seq_LS180_Human1.25033339
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24160676
44BCOR_27268052_Chip-Seq_Bcells_Human1.23451404
45PHF8_20622854_ChIP-Seq_HELA_Human1.23161735
46AR_21572438_ChIP-Seq_LNCaP_Human1.22406601
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20929400
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.20310826
49MAF_26560356_Chip-Seq_TH1_Human1.19289165
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18244046
51BCL6_27268052_Chip-Seq_Bcells_Human1.17918244
52SMC4_20622854_ChIP-Seq_HELA_Human1.16583353
53UTX_26944678_Chip-Seq_JUKART_Human1.15924492
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15237167
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15183451
56OCT4_20526341_ChIP-Seq_ESCs_Human1.13364440
57TAF2_19829295_ChIP-Seq_ESCs_Human1.12999668
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12877014
59RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.10523448
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10427334
61ER_23166858_ChIP-Seq_MCF-7_Human1.09459490
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09187873
63GATA3_26560356_Chip-Seq_TH2_Human1.07509448
64KDM2B_26808549_Chip-Seq_DND41_Human1.06655219
65MYB_26560356_Chip-Seq_TH1_Human1.06483170
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05814191
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.05525267
68P300_27268052_Chip-Seq_Bcells_Human1.05058156
69SA1_27219007_Chip-Seq_Bcells_Human1.03190111
70WDR5_24793694_ChIP-Seq_LNCAP_Human1.02975660
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00695701
72TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00430723
73RAC3_21632823_ChIP-Seq_H3396_Human1.00386492
74TP53_22573176_ChIP-Seq_HFKS_Human0.99396928
75TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98553016
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97395394
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97395394
78PRDM14_20953172_ChIP-Seq_ESCs_Human0.97249220
79MYC_19829295_ChIP-Seq_ESCs_Human0.96948575
80CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96827086
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96695372
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96636165
83CTCF_20526341_ChIP-Seq_ESCs_Human0.95653251
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95558248
85ELF1_20517297_ChIP-Seq_JURKAT_Human0.95419083
86HOXB7_26014856_ChIP-Seq_BT474_Human0.94192457
87FOXA1_25329375_ChIP-Seq_VCAP_Human0.93700544
88FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93700544
89STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92313345
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91452642
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91012785
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90048307
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89100569
94BCAT_22108803_ChIP-Seq_LS180_Human0.89064637
95YY1_22570637_ChIP-Seq_MALME-3M_Human0.88926586
96FLI1_21867929_ChIP-Seq_CD8_Mouse0.88645582
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87576163
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87573512
99SMRT_27268052_Chip-Seq_Bcells_Human0.87492311
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86567657

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.37678133
2MP0001873_stomach_inflammation3.04018191
3MP0008877_abnormal_DNA_methylation2.89599349
4MP0005671_abnormal_response_to2.74715671
5MP0003787_abnormal_imprinting2.57658693
6MP0004381_abnormal_hair_follicle2.42751734
7MP0002138_abnormal_hepatobiliary_system2.13599953
8MP0004043_abnormal_pH_regulation2.04508777
9MP0005423_abnormal_somatic_nervous2.02378100
10MP0009745_abnormal_behavioral_response2.01906128
11MP0001800_abnormal_humoral_immune1.92290080
12MP0004742_abnormal_vestibular_system1.85645143
13MP0001986_abnormal_taste_sensitivity1.82611519
14MP0003635_abnormal_synaptic_transmissio1.81940269
15MP0002822_catalepsy1.78302774
16MP0009333_abnormal_splenocyte_physiolog1.74382814
17MP0005310_abnormal_salivary_gland1.73292108
18MP0005645_abnormal_hypothalamus_physiol1.73109790
19MP0002064_seizures1.72359513
20MP0002653_abnormal_ependyma_morphology1.72020005
21MP0004859_abnormal_synaptic_plasticity1.69765607
22MP0001968_abnormal_touch/_nociception1.69394335
23MP0003866_abnormal_defecation1.68386294
24MP0002163_abnormal_gland_morphology1.68192565
25MP0000569_abnormal_digit_pigmentation1.67338813
26MP0002272_abnormal_nervous_system1.63529983
27MP0001348_abnormal_lacrimal_gland1.61465405
28MP0003880_abnormal_central_pattern1.59355895
29MP0003195_calcinosis1.58939910
30MP0001790_abnormal_immune_system1.58141854
31MP0005387_immune_system_phenotype1.58141854
32MP0001501_abnormal_sleep_pattern1.56437255
33MP0002063_abnormal_learning/memory/cond1.53944204
34MP0008961_abnormal_basal_metabolism1.51805930
35MP0002572_abnormal_emotion/affect_behav1.48626361
36MP0000685_abnormal_immune_system1.45442757
37MP0002876_abnormal_thyroid_physiology1.42633037
38MP0004142_abnormal_muscle_tone1.41357362
39MP0000703_abnormal_thymus_morphology1.39376627
40MP0002928_abnormal_bile_duct1.39193263
41MP0005075_abnormal_melanosome_morpholog1.36798172
42MP0008872_abnormal_physiological_respon1.32466392
43MP0001919_abnormal_reproductive_system1.32420053
44MP0002723_abnormal_immune_serum1.31744842
45MP0004885_abnormal_endolymph1.31125503
46MP0002735_abnormal_chemical_nociception1.27999335
47MP0009046_muscle_twitch1.27906583
48MP0002277_abnormal_respiratory_mucosa1.26784160
49MP0005000_abnormal_immune_tolerance1.23854871
50MP0005551_abnormal_eye_electrophysiolog1.23201267
51MP0002420_abnormal_adaptive_immunity1.23101121
52MP0002693_abnormal_pancreas_physiology1.22706141
53MP0002909_abnormal_adrenal_gland1.21546609
54MP0001486_abnormal_startle_reflex1.21169215
55MP0001970_abnormal_pain_threshold1.20006844
56MP0001819_abnormal_immune_cell1.18868982
57MP0001765_abnormal_ion_homeostasis1.17591859
58MP0002067_abnormal_sensory_capabilities1.16220412
59MP0002733_abnormal_thermal_nociception1.15201229
60MP0003123_paternal_imprinting1.14186347
61MP0002638_abnormal_pupillary_reflex1.13937449
62MP0005379_endocrine/exocrine_gland_phen1.13481843
63MP0002557_abnormal_social/conspecific_i1.10573277
64MP0005377_hearing/vestibular/ear_phenot1.09631816
65MP0003878_abnormal_ear_physiology1.09631816
66MP0000427_abnormal_hair_cycle1.09514723
67MP0001485_abnormal_pinna_reflex1.08368858
68MP0003646_muscle_fatigue1.07699340
69MP0006276_abnormal_autonomic_nervous1.06909653
70MP0001502_abnormal_circadian_rhythm1.06371144
71MP0002398_abnormal_bone_marrow1.03523626
72MP0000716_abnormal_immune_system1.02843059
73MP0002452_abnormal_antigen_presenting1.02672278
74MP0002254_reproductive_system_inflammat1.02285269
75MP0008569_lethality_at_weaning1.01928719
76MP0004130_abnormal_muscle_cell1.01357225
77MP0003879_abnormal_hair_cell1.01139095
78MP0001440_abnormal_grooming_behavior1.00820079
79MP0004924_abnormal_behavior0.97671929
80MP0005386_behavior/neurological_phenoty0.97671929
81MP0001835_abnormal_antigen_presentation0.95272258
82MP0003436_decreased_susceptibility_to0.94121842
83MP0005389_reproductive_system_phenotype0.94117483
84MP0001905_abnormal_dopamine_level0.93232711
85MP0005025_abnormal_response_to0.92515672
86MP0002734_abnormal_mechanical_nocicepti0.92071268
87MP0004947_skin_inflammation0.88823081
88MP0002184_abnormal_innervation0.88077167
89MP0000689_abnormal_spleen_morphology0.87596779
90MP0008875_abnormal_xenobiotic_pharmacok0.87159191
91MP0003136_yellow_coat_color0.86846184
92MP0005646_abnormal_pituitary_gland0.86119132
93MP0000631_abnormal_neuroendocrine_gland0.85080869
94MP0001944_abnormal_pancreas_morphology0.84478980
95MP0001188_hyperpigmentation0.82428446
96MP0002229_neurodegeneration0.81857593
97MP0002405_respiratory_system_inflammati0.80057356
98MP0005448_abnormal_energy_balance0.79844198
99MP0002736_abnormal_nociception_after0.77949296
100MP0002160_abnormal_reproductive_system0.77223800

Predicted human phenotypes

RankGene SetZ-score
1Progressive cerebellar ataxia (HP:0002073)3.79642611
2Stomatitis (HP:0010280)3.48384369
3Elevated erythrocyte sedimentation rate (HP:0003565)3.47840062
4Congenital stationary night blindness (HP:0007642)3.30159549
5Increased circulating renin level (HP:0000848)3.22279880
6Metabolic alkalosis (HP:0200114)3.08973114
7Abnormality of T cell number (HP:0011839)3.05985663
8Polydipsia (HP:0001959)3.00535950
9Abnormal drinking behavior (HP:0030082)3.00535950
10Abnormal delayed hypersensitivity skin test (HP:0002963)2.95718887
11T lymphocytopenia (HP:0005403)2.87687777
12Polyuria (HP:0000103)2.85864502
13Genetic anticipation (HP:0003743)2.81387126
14Papilledema (HP:0001085)2.80857523
15Hypokalemic alkalosis (HP:0001949)2.72402100
16Severe combined immunodeficiency (HP:0004430)2.64791451
17Hypomagnesemia (HP:0002917)2.62523480
18Epileptic encephalopathy (HP:0200134)2.62517909
19Hyperactive renin-angiotensin system (HP:0000841)2.60781074
20Febrile seizures (HP:0002373)2.55281703
21Pancreatic cysts (HP:0001737)2.55033720
22Abnormality of chloride homeostasis (HP:0011422)2.53695036
23Abnormality of renin-angiotensin system (HP:0000847)2.51028224
24IgG deficiency (HP:0004315)2.49153051
25Molar tooth sign on MRI (HP:0002419)2.48134194
26Abnormality of midbrain morphology (HP:0002418)2.48134194
27Tubular atrophy (HP:0000092)2.43752110
28Abnormality of T cells (HP:0002843)2.42403766
29Type II lissencephaly (HP:0007260)2.41300758
30Focal motor seizures (HP:0011153)2.35064030
31Pustule (HP:0200039)2.33804575
32Hyperventilation (HP:0002883)2.32869708
33Myokymia (HP:0002411)2.32277222
34Abnormal urine output (HP:0012590)2.27188340
35Abnormality of the renal cortex (HP:0011035)2.24339251
36Autoimmune hemolytic anemia (HP:0001890)2.20863778
37Abnormality of renal excretion (HP:0011036)2.19848495
38Abnormality of eosinophils (HP:0001879)2.19660239
39Abnormality of the renal medulla (HP:0100957)2.19227890
40Oligodactyly (hands) (HP:0001180)2.16107186
41Gaze-evoked nystagmus (HP:0000640)2.15159019
42Hyperaldosteronism (HP:0000859)2.13706853
43Panhypogammaglobulinemia (HP:0003139)2.11317905
44Alkalosis (HP:0001948)2.10181887
45Renal salt wasting (HP:0000127)2.09028125
46Concave nail (HP:0001598)2.08672468
47Hypochromic anemia (HP:0001931)2.08092235
48Nephronophthisis (HP:0000090)2.07570707
49Focal seizures (HP:0007359)2.05335341
50Limb dystonia (HP:0002451)2.02634467
51Abnormality of the fingertips (HP:0001211)1.99627238
52Decreased circulating renin level (HP:0003351)1.98548135
53Increased IgM level (HP:0003496)1.98077546
54Clumsiness (HP:0002312)1.96441245
55Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94712514
56Broad-based gait (HP:0002136)1.93896063
57Cystic liver disease (HP:0006706)1.92769573
58Abnormal rod and cone electroretinograms (HP:0008323)1.90736759
59Abnormality of B cell number (HP:0010975)1.90582761
60Recurrent fungal infections (HP:0002841)1.90420981
61Status epilepticus (HP:0002133)1.89873819
62Tetany (HP:0001281)1.89475969
63Abnormality of magnesium homeostasis (HP:0004921)1.89294811
64Chronic diarrhea (HP:0002028)1.89225407
65Impaired smooth pursuit (HP:0007772)1.88104828
66Chronic hepatic failure (HP:0100626)1.86689959
67Parakeratosis (HP:0001036)1.86534151
68Thyroiditis (HP:0100646)1.83787184
69Amelogenesis imperfecta (HP:0000705)1.82082657
70Stomach cancer (HP:0012126)1.81488903
71Retinal dysplasia (HP:0007973)1.80721513
72Hypoplasia of the pons (HP:0012110)1.79661853
73Retrobulbar optic neuritis (HP:0100654)1.78852433
74Optic neuritis (HP:0100653)1.78852433
75Pendular nystagmus (HP:0012043)1.78256078
76Pancreatic fibrosis (HP:0100732)1.78041798
77Large for gestational age (HP:0001520)1.77958022
78Inability to walk (HP:0002540)1.77950729
79Attenuation of retinal blood vessels (HP:0007843)1.76276337
80Protruding tongue (HP:0010808)1.75948382
81Increased IgE level (HP:0003212)1.75756315
82Visual hallucinations (HP:0002367)1.75590858
83Encephalitis (HP:0002383)1.75487499
84Abnormality of binocular vision (HP:0011514)1.75367869
85Diplopia (HP:0000651)1.75367869
86Abnormality of the pons (HP:0007361)1.74993277
87Neonatal hypoglycemia (HP:0001998)1.73809881
88Recurrent bronchitis (HP:0002837)1.73780820
89B lymphocytopenia (HP:0010976)1.72996966
90Agitation (HP:0000713)1.72824282
91Abnormality of T cell physiology (HP:0011840)1.71364623
92Bony spicule pigmentary retinopathy (HP:0007737)1.69226240
93Eosinophilia (HP:0001880)1.67089001
94Oligodontia (HP:0000677)1.66919328
95Severe visual impairment (HP:0001141)1.66273341
96Vasculitis (HP:0002633)1.66078995
97Generalized hypopigmentation of hair (HP:0011358)1.65470206
98Gastrointestinal infarctions (HP:0005244)1.65067615
99Urinary bladder sphincter dysfunction (HP:0002839)1.64772262
100Hypokalemia (HP:0002900)1.64276100

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.00692984
2TXK3.62542518
3CAMKK12.69915203
4WNK32.58251323
5SIK22.44225060
6CAMKK22.27783015
7FRK2.22518386
8OXSR12.18884482
9PASK2.09584752
10ITK2.07183329
11TNK22.04499904
12TYRO31.80496424
13WNK41.78855375
14NTRK21.66461077
15NLK1.60885696
16NTRK31.59607659
17CASK1.56609526
18DAPK21.51404154
19TAOK11.49171711
20ADRBK21.47505697
21MAP3K91.45232788
22FES1.37236798
23MAPK131.37110600
24IKBKE1.35346259
25CAMK1D1.34362202
26PRKCH1.32213505
27GRK61.29717632
28MAP3K111.27374165
29BTK1.26498471
30STK111.25614238
31MARK21.23958153
32SGK21.23419404
33TLK11.21562993
34SGK4941.18760954
35SGK2231.18760954
36MAP2K61.17257337
37LCK1.12080425
38BMPR1B1.11601118
39CDK191.05243165
40ZAP701.01921861
41PRKCQ1.01215559
42MARK30.98275963
43CAMK10.95435152
44FGFR20.95112645
45CAMK1G0.94989366
46IKBKB0.94195587
47RIPK40.94184587
48SYK0.91523061
49MAPK150.90319136
50PIK3CA0.88650713
51TAOK30.88461746
52TRIB30.85940473
53PRKCI0.85932375
54MARK10.83944635
55CHUK0.83827790
56PNCK0.82409603
57GRK10.81459303
58PRKD20.80345000
59MAP3K70.80082236
60STK390.78634549
61PRKD30.77964813
62PAK30.77817467
63MAP3K130.77199966
64FGFR40.76856575
65NEK60.75714722
66TEC0.75442787
67SIK30.75216539
68INSRR0.73905303
69IRAK40.73881320
70DYRK20.73806602
71PRKCG0.73217997
72UHMK10.72367453
73SGK30.71930817
74FGFR30.71917144
75HIPK20.71847823
76PDK10.70476806
77WNK10.69482500
78MAP3K40.68315653
79STK380.66949410
80PRKCZ0.66515004
81MAP2K20.63788465
82CSK0.63497772
83SIK10.61563517
84CAMK40.61251033
85JAK30.61168730
86HCK0.59825166
87SGK10.58233509
88DYRK1A0.55176890
89JAK10.54832189
90MINK10.51936460
91PINK10.50499392
92MAPK120.50341504
93MAPK110.44542347
94CDK50.44220902
95IRAK10.43511282
96LYN0.42784197
97PIM10.40301183
98MAP2K70.40139491
99MAPK80.38803834
100RPS6KA60.37847921

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.78498494
2T cell receptor signaling pathway_Homo sapiens_hsa046603.02849077
3Nicotine addiction_Homo sapiens_hsa050332.76043074
4Phototransduction_Homo sapiens_hsa047442.37212345
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.34415459
6Linoleic acid metabolism_Homo sapiens_hsa005912.27208451
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06027400
8Morphine addiction_Homo sapiens_hsa050321.90217315
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.89134181
10Autoimmune thyroid disease_Homo sapiens_hsa053201.74471566
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.68752512
12Graft-versus-host disease_Homo sapiens_hsa053321.64314984
13Allograft rejection_Homo sapiens_hsa053301.55934004
14Type I diabetes mellitus_Homo sapiens_hsa049401.52388935
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51090606
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.50093795
17Insulin secretion_Homo sapiens_hsa049111.45289810
18B cell receptor signaling pathway_Homo sapiens_hsa046621.42762470
19Glutamatergic synapse_Homo sapiens_hsa047241.39132698
20Circadian entrainment_Homo sapiens_hsa047131.37909314
21Amphetamine addiction_Homo sapiens_hsa050311.35143602
22GABAergic synapse_Homo sapiens_hsa047271.34409963
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30734442
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28978386
25Ether lipid metabolism_Homo sapiens_hsa005651.28952993
26Synaptic vesicle cycle_Homo sapiens_hsa047211.27502928
27Cholinergic synapse_Homo sapiens_hsa047251.26299172
28Taste transduction_Homo sapiens_hsa047421.25039190
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.24879384
30ABC transporters_Homo sapiens_hsa020101.24112030
31Dorso-ventral axis formation_Homo sapiens_hsa043201.23945554
32Dopaminergic synapse_Homo sapiens_hsa047281.22264548
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20805675
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19500149
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17881146
36VEGF signaling pathway_Homo sapiens_hsa043701.15758001
37Type II diabetes mellitus_Homo sapiens_hsa049301.15736885
38MAPK signaling pathway_Homo sapiens_hsa040101.14764916
39Serotonergic synapse_Homo sapiens_hsa047261.12684806
40Cocaine addiction_Homo sapiens_hsa050301.12001167
41Measles_Homo sapiens_hsa051621.10955854
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07900600
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.04957742
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04365710
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.04062465
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99649261
47Gastric acid secretion_Homo sapiens_hsa049710.98593895
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95754510
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93595336
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93248226
51Chemokine signaling pathway_Homo sapiens_hsa040620.92212182
52cAMP signaling pathway_Homo sapiens_hsa040240.91641157
53Prolactin signaling pathway_Homo sapiens_hsa049170.87636316
54Long-term potentiation_Homo sapiens_hsa047200.86716800
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86132118
56Oxytocin signaling pathway_Homo sapiens_hsa049210.84509444
57Olfactory transduction_Homo sapiens_hsa047400.83596013
58Ovarian steroidogenesis_Homo sapiens_hsa049130.83115211
59Regulation of autophagy_Homo sapiens_hsa041400.82372945
60Caffeine metabolism_Homo sapiens_hsa002320.82192449
61Acute myeloid leukemia_Homo sapiens_hsa052210.79381311
62Butanoate metabolism_Homo sapiens_hsa006500.79025241
63Choline metabolism in cancer_Homo sapiens_hsa052310.78381591
64Calcium signaling pathway_Homo sapiens_hsa040200.77263596
65Long-term depression_Homo sapiens_hsa047300.76914518
66Ras signaling pathway_Homo sapiens_hsa040140.76671393
67Collecting duct acid secretion_Homo sapiens_hsa049660.71240338
68Hematopoietic cell lineage_Homo sapiens_hsa046400.68338524
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.66204608
70Selenocompound metabolism_Homo sapiens_hsa004500.65278858
71Inositol phosphate metabolism_Homo sapiens_hsa005620.62168380
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.61174695
73TNF signaling pathway_Homo sapiens_hsa046680.61153571
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59746169
75FoxO signaling pathway_Homo sapiens_hsa040680.58228497
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57271215
77Antigen processing and presentation_Homo sapiens_hsa046120.56523990
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56285480
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54757867
80Arachidonic acid metabolism_Homo sapiens_hsa005900.53327486
81Axon guidance_Homo sapiens_hsa043600.53134549
82Glycerolipid metabolism_Homo sapiens_hsa005610.52028098
83ErbB signaling pathway_Homo sapiens_hsa040120.51222173
84Fatty acid biosynthesis_Homo sapiens_hsa000610.51174169
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50647555
86GnRH signaling pathway_Homo sapiens_hsa049120.50263661
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49428799
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.49385606
89Osteoclast differentiation_Homo sapiens_hsa043800.48868805
90Salivary secretion_Homo sapiens_hsa049700.48149591
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46250416
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.46226643
93Non-small cell lung cancer_Homo sapiens_hsa052230.45547651
94Retinol metabolism_Homo sapiens_hsa008300.43792871
95Insulin resistance_Homo sapiens_hsa049310.42578654
96Estrogen signaling pathway_Homo sapiens_hsa049150.42037596
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.41244357
98mTOR signaling pathway_Homo sapiens_hsa041500.40375013
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39917188
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.39777582

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