ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	9.18319621
2	desmosome organization (GO:0002934)	7.95385201
3	cilium or flagellum-dependent cell motility (GO:0001539)	7.42114065
4	motile cilium assembly (GO:0044458)	6.67659575
5	cilium movement (GO:0003341)	6.33800781
6	primary alcohol catabolic process (GO:0034310)	5.96734798
7	multicellular organismal water homeostasis (GO:0050891)	5.93659422
8	regulation of water loss via skin (GO:0033561)	5.88570708
9	establishment of skin barrier (GO:0061436)	5.81809440
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.76086736
11	vitamin transmembrane transport (GO:0035461)	5.28214954
12	ethanol metabolic process (GO:0006067)	5.26326867
13	epithelial cilium movement (GO:0003351)	5.15263797
14	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.08462481
15	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	5.07132258
16	water homeostasis (GO:0030104)	4.93691289
17	intestinal epithelial cell development (GO:0060576)	4.90852878
18	keratinization (GO:0031424)	4.56666261
19	axoneme assembly (GO:0035082)	4.42291691
20	lung epithelium development (GO:0060428)	4.27007829
21	establishment of apical/basal cell polarity (GO:0035089)	4.11656772
22	O-glycan processing (GO:0016266)	4.08448808
23	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.00837268
24	ethanol oxidation (GO:0006069)	3.95518388
25	ear development (GO:0043583)	3.83305177
26	glutathione biosynthetic process (GO:0006750)	3.81727883
27	diterpenoid biosynthetic process (GO:0016102)	3.75682726
28	regulation of ruffle assembly (GO:1900027)	3.67451871
29	GDP-mannose metabolic process (GO:0019673)	3.64186696
30	one-carbon compound transport (GO:0019755)	3.58559451
31	establishment of tissue polarity (GO:0007164)	3.57657934
32	establishment of planar polarity (GO:0001736)	3.57657934
33	positive regulation of Cdc42 GTPase activity (GO:0043089)	3.57035596
34	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.52633166
35	nonribosomal peptide biosynthetic process (GO:0019184)	3.49509969
36	epithelial cell-cell adhesion (GO:0090136)	3.49373088
37	left/right pattern formation (GO:0060972)	3.46884672
38	establishment of monopolar cell polarity (GO:0061162)	3.41521195
39	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.41521195
40	negative regulation of T cell differentiation in thymus (GO:0033085)	3.38050581
41	semaphorin-plexin signaling pathway (GO:0071526)	3.30230628
42	striated muscle atrophy (GO:0014891)	3.27219539
43	maintenance of gastrointestinal epithelium (GO:0030277)	3.27148547
44	negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	3.26112035
45	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.24859662
46	keratinocyte differentiation (GO:0030216)	3.24298078
47	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.19136730
48	intestinal absorption (GO:0050892)	3.18155770
49	planar cell polarity pathway involved in neural tube closure (GO:0090179)	3.10799836
50	primary alcohol metabolic process (GO:0034308)	3.10270143
51	oligosaccharide biosynthetic process (GO:0009312)	3.09035043
52	regulation of keratinocyte differentiation (GO:0045616)	3.07514655
53	peptidyl-tyrosine autophosphorylation (GO:0038083)	3.04094765
54	positive regulation of epidermal cell differentiation (GO:0045606)	3.03872593
55	peptide cross-linking (GO:0018149)	3.03676598
56	flavonoid metabolic process (GO:0009812)	3.03512580
57	apical protein localization (GO:0045176)	3.03143494
58	epidermal cell differentiation (GO:0009913)	3.02744845
59	excretion (GO:0007588)	3.01796780
60	keratinocyte proliferation (GO:0043616)	3.01408657
61	sperm capacitation (GO:0048240)	2.98800554
62	tight junction assembly (GO:0070830)	2.97148434
63	regulation of guanylate cyclase activity (GO:0031282)	2.93204105
64	endothelial cell chemotaxis (GO:0035767)	2.89834406
65	phosphatidylcholine biosynthetic process (GO:0006656)	2.88903288
66	retinol metabolic process (GO:0042572)	2.88806937
67	renal absorption (GO:0070293)	2.82467647
68	regulation of interleukin-13 production (GO:0032656)	2.81708244
69	sodium ion homeostasis (GO:0055078)	2.81545583
70	retinoic acid metabolic process (GO:0042573)	2.77958378
71	regulation of viral release from host cell (GO:1902186)	2.77589943
72	skeletal muscle adaptation (GO:0043501)	2.76756658
73	regulation of respiratory burst (GO:0060263)	2.76022356
74	positive regulation of keratinocyte differentiation (GO:0045618)	2.75658174
75	regulation of interleukin-5 production (GO:0032674)	2.75002286
76	epidermis development (GO:0008544)	2.74281725
77	sphingomyelin metabolic process (GO:0006684)	2.74159125
78	sulfate transmembrane transport (GO:1902358)	2.72627161
79	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.71889482
80	sulfur compound transport (GO:0072348)	2.71331582
81	asymmetric protein localization (GO:0008105)	2.71197382
82	exogenous drug catabolic process (GO:0042738)	2.70742107
83	regulation of fatty acid beta-oxidation (GO:0031998)	2.69385268
84	glomerular filtration (GO:0003094)	2.68568355
85	renal system process involved in regulation of blood volume (GO:0001977)	2.68502000
86	response to food (GO:0032094)	2.68017101
87	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	2.66991074
88	protein O-linked glycosylation (GO:0006493)	2.66940371
89	drug catabolic process (GO:0042737)	2.65869473
90	muscle atrophy (GO:0014889)	2.63977228
91	renal filtration (GO:0097205)	2.63053604
92	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.61965861
93	keratinocyte development (GO:0003334)	2.59453812
94	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	2.59355001
95	epoxygenase P450 pathway (GO:0019373)	2.59013704
96	regulation of Cdc42 GTPase activity (GO:0043088)	2.58003846
97	microtubule bundle formation (GO:0001578)	2.56770768
98	gap junction assembly (GO:0016264)	2.56621607
99	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.55871464
100	transepithelial transport (GO:0070633)	2.54787372

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	5.61472338
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.54237917
3	ESR1_21235772_ChIP-Seq_MCF-7_Human	4.01743105
4	ESR2_21235772_ChIP-Seq_MCF-7_Human	3.85631938
5	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.09094723
6	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.98160962
7	RACK7_27058665_Chip-Seq_MCF-7_Human	2.81890443
8	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.81749064
9	RUNX1_27514584_Chip-Seq_MCF-7_Human	2.63511253
10	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.57452946
11	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.35198570
12	SOX2_27498859_Chip-Seq_STOMACH_Mouse	2.32609314
13	LXR_22292898_ChIP-Seq_THP-1_Human	2.29182218
14	P63_26484246_Chip-Seq_KERATINOCYTES_Human	2.26801318
15	ZNF263_19887448_ChIP-Seq_K562_Human	2.14012783
16	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.91846482
17	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.86261418
18	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.85562308
19	DROSHA_22980978_ChIP-Seq_HELA_Human	1.83581548
20	KLF5_25053715_ChIP-Seq_YYC3_Human	1.83413529
21	P68_20966046_ChIP-Seq_HELA_Human	1.80933813
22	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.79619601
23	GATA6_25053715_ChIP-Seq_YYC3_Human	1.77805353
24	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.77556067
25	SMC4_20622854_ChIP-Seq_HELA_Human	1.76885746
26	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.76103159
27	SOX2_20726797_ChIP-Seq_SW620_Human	1.72322764
28	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.71843057
29	CREB1_26743006_Chip-Seq_LNCaP_Human	1.71646921
30	CTCF_27219007_Chip-Seq_Bcells_Human	1.70872353
31	TP63_22573176_ChIP-Seq_HFKS_Human	1.67464621
32	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.64875183
33	GATA4_25053715_ChIP-Seq_YYC3_Human	1.59790451
34	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.58720529
35	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.58192916
36	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.56210378
37	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.54257620
38	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.52419063
39	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.50906170
40	BCOR_27268052_Chip-Seq_Bcells_Human	1.44611015
41	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.44078795
42	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.43069331
43	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.38755740
44	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.37907124
45	E2F1_20622854_ChIP-Seq_HELA_Human	1.37395188
46	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.35678965
47	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.34909170
48	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.34212682
49	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.33831514
50	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.32689906
51	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.32014768
52	BCL6_27268052_Chip-Seq_Bcells_Human	1.30677677
53	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.29221484
54	PHF8_20622854_ChIP-Seq_HELA_Human	1.28987227
55	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.28778081
56	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.28350703
57	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.27895065
58	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.27580991
59	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.27470183
60	CTCF_20526341_ChIP-Seq_ESCs_Human	1.26155870
61	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.24601519
62	AHR_22903824_ChIP-Seq_MCF-7_Human	1.24113090
63	SA1_27219007_Chip-Seq_Bcells_Human	1.24061928
64	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.23561923
65	ATF3_27146783_Chip-Seq_COLON_Human	1.23447763
66	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.16582596
67	KDM2B_26808549_Chip-Seq_K562_Human	1.15209221
68	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.14734918
69	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.14729394
70	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.13826299
71	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.13255232
72	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.12523074
73	TCF7_22412390_ChIP-Seq_EML_Mouse	1.10400309
74	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.09716677
75	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.09388554
76	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.08944254
77	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.07208961
78	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.06427600
79	VDR_21846776_ChIP-Seq_THP-1_Human	1.05999706
80	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.03518608
81	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.03242528
82	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.02605256
83	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.00374624
84	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.99949687
85	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.99546991
86	STAT1_20625510_ChIP-Seq_HELA_Human	0.99524012
87	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.98506454
88	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.98420871
89	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.97493067
90	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97212205
91	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.94480172
92	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	0.93603530
93	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	0.93603530
94	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.93447313
95	P300_27268052_Chip-Seq_Bcells_Human	0.90595175
96	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.89592034
97	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.89167016
98	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.88121313
99	KDM2B_26808549_Chip-Seq_DND41_Human	0.87873383
100	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.87818489

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	6.96283644
2	MP0002796_impaired_skin_barrier	4.96654466
3	MP0004043_abnormal_pH_regulation	3.80882123
4	MP0004264_abnormal_extraembryonic_tissu	3.66948008
5	MP0000566_synostosis	3.29427463
6	MP0008875_abnormal_xenobiotic_pharmacok	3.08118438
7	MP0010678_abnormal_skin_adnexa	2.94934956
8	MP0002098_abnormal_vibrissa_morphology	2.86571710
9	MP0005501_abnormal_skin_physiology	2.85180157
10	MP0009780_abnormal_chondrocyte_physiolo	2.67883216
11	MP0000383_abnormal_hair_follicle	2.65848563
12	MP0003453_abnormal_keratinocyte_physiol	2.42886597
13	MP0002653_abnormal_ependyma_morphology	2.23943414
14	MP0005409_darkened_coat_color	2.19110655
15	MP0000678_abnormal_parathyroid_gland	2.18910657
16	MP0000579_abnormal_nail_morphology	2.17341711
17	MP0004019_abnormal_vitamin_homeostasis	2.12980266
18	MP0009379_abnormal_foot_pigmentation	2.10399161
19	MP0005083_abnormal_biliary_tract	2.07931001
20	MP0000467_abnormal_esophagus_morphology	2.07479122
21	MP0004782_abnormal_surfactant_physiolog	2.02681388
22	MP0005377_hearing/vestibular/ear_phenot	2.02365778
23	MP0003878_abnormal_ear_physiology	2.02365778
24	MP0001765_abnormal_ion_homeostasis	2.01351487
25	MP0003705_abnormal_hypodermis_morpholog	1.90475214
26	MP0001216_abnormal_epidermal_layer	1.90118924
27	MP0001666_abnormal_nutrient_absorption	1.81633187
28	MP0004381_abnormal_hair_follicle	1.74804008
29	MP0010155_abnormal_intestine_physiology	1.72190066
30	MP0001664_abnormal_digestion	1.69247906
31	MP0010352_gastrointestinal_tract_polyps	1.66967775
32	MP0000377_abnormal_hair_follicle	1.62114172
33	MP0005360_urolithiasis	1.61840805
34	MP0002249_abnormal_larynx_morphology	1.61506889
35	MP0001873_stomach_inflammation	1.59145189
36	MP0010771_integument_phenotype	1.54436452
37	MP0005365_abnormal_bile_salt	1.53286080
38	MP0003866_abnormal_defecation	1.48982494
39	MP0001849_ear_inflammation	1.47138114
40	MP0001188_hyperpigmentation	1.45686545
41	MP0002277_abnormal_respiratory_mucosa	1.45313963
42	MP0005085_abnormal_gallbladder_physiolo	1.42350332
43	MP0005076_abnormal_cell_differentiation	1.34534650
44	MP0005275_abnormal_skin_tensile	1.31907663
45	MP0002254_reproductive_system_inflammat	1.31207900
46	MP0002060_abnormal_skin_morphology	1.27160327
47	MP0002139_abnormal_hepatobiliary_system	1.26453489
48	MP0000477_abnormal_intestine_morphology	1.26313372
49	MP0002132_abnormal_respiratory_system	1.22126859
50	MP0003183_abnormal_peptide_metabolism	1.22029998
51	MP0000427_abnormal_hair_cycle	1.21448805
52	MP0009643_abnormal_urine_homeostasis	1.19741923
53	MP0004947_skin_inflammation	1.18488783
54	MP0004858_abnormal_nervous_system	1.12929381
55	MP0000470_abnormal_stomach_morphology	1.12111037
56	MP0005636_abnormal_mineral_homeostasis	1.08533071
57	MP0002876_abnormal_thyroid_physiology	1.05817755
58	MP0001756_abnormal_urination	1.05091163
59	MP0009931_abnormal_skin_appearance	1.03462026
60	MP0003941_abnormal_skin_development	1.02695376
61	MP0000762_abnormal_tongue_morphology	1.01978860
62	MP0002136_abnormal_kidney_physiology	1.01161418
63	MP0000627_abnormal_mammary_gland	0.97122636
64	MP0000490_abnormal_crypts_of	0.91965587
65	MP0001663_abnormal_digestive_system	0.89373567
66	MP0008872_abnormal_physiological_respon	0.86578518
67	MP0000367_abnormal_coat/_hair	0.86000137
68	MP0001881_abnormal_mammary_gland	0.84311997
69	MP0005381_digestive/alimentary_phenotyp	0.84085775
70	MP0005023_abnormal_wound_healing	0.81971704
71	MP0000537_abnormal_urethra_morphology	0.79906665
72	MP0002909_abnormal_adrenal_gland	0.79744321
73	MP0000462_abnormal_digestive_system	0.79559558
74	MP0001485_abnormal_pinna_reflex	0.79178684
75	MP0004133_heterotaxia	0.78174969
76	MP0003638_abnormal_response/metabolism_	0.77829612
77	MP0009384_cardiac_valve_regurgitation	0.76271433
78	MP0000538_abnormal_urinary_bladder	0.74587580
79	MP0000465_gastrointestinal_hemorrhage	0.74286642
80	MP0003566_abnormal_cell_adhesion	0.73224415
81	MP0001502_abnormal_circadian_rhythm	0.69246197
82	MP0004185_abnormal_adipocyte_glucose	0.67047027
83	MP0000013_abnormal_adipose_tissue	0.66492647
84	MP0010030_abnormal_orbit_morphology	0.65766510
85	MP0003136_yellow_coat_color	0.64335235
86	MP0002896_abnormal_bone_mineralization	0.62540009
87	MP0005666_abnormal_adipose_tissue	0.61751471
88	MP0005670_abnormal_white_adipose	0.60920287
89	MP0003045_fibrosis	0.60495379
90	MP0002282_abnormal_trachea_morphology	0.59943805
91	MP0003879_abnormal_hair_cell	0.56849116
92	MP0010329_abnormal_lipoprotein_level	0.55029879
93	MP0005310_abnormal_salivary_gland	0.55010263
94	MP0002118_abnormal_lipid_homeostasis	0.53282327
95	MP0002168_other_aberrant_phenotype	0.51962354
96	MP0001346_abnormal_lacrimal_gland	0.50615150
97	MP0004885_abnormal_endolymph	0.49981808
98	MP0005503_abnormal_tendon_morphology	0.49617287
99	MP0002089_abnormal_postnatal_growth/wei	0.48890637
100	MP0001243_abnormal_dermal_layer	0.48195902

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	7.89261732
2	Abnormal respiratory motile cilium morphology (HP:0005938)	7.20237196
3	Abnormal respiratory epithelium morphology (HP:0012253)	7.20237196
4	Absent/shortened dynein arms (HP:0200106)	6.99668716
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.99668716
6	Abnormal respiratory motile cilium physiology (HP:0012261)	6.77172880
7	Abnormal ciliary motility (HP:0012262)	6.64754154
8	Chronic bronchitis (HP:0004469)	6.50129140
9	Rhinitis (HP:0012384)	6.25810057
10	Hyperactive renin-angiotensin system (HP:0000841)	5.86967117
11	Nasal polyposis (HP:0100582)	5.19440187
12	Bronchiectasis (HP:0002110)	5.17782280
13	Abnormality of the nasal mucosa (HP:0000433)	4.57684454
14	Decreased circulating renin level (HP:0003351)	4.57328185
15	Pili torti (HP:0003777)	3.79075850
16	Right ventricular cardiomyopathy (HP:0011663)	3.76051209
17	Abnormality of renin-angiotensin system (HP:0000847)	3.67058257
18	Bronchitis (HP:0012387)	3.39480432
19	Malnutrition (HP:0004395)	3.38796949
20	Lip pit (HP:0100267)	3.38101855
21	Flat acetabular roof (HP:0003180)	3.14756171
22	Abnormality of nail color (HP:0100643)	3.10115420
23	Abnormal hair laboratory examination (HP:0003328)	3.02124895
24	Abnormality of chloride homeostasis (HP:0011422)	2.96302504
25	Infertility (HP:0000789)	2.86322711
26	Palmoplantar hyperkeratosis (HP:0000972)	2.84744504
27	Renal salt wasting (HP:0000127)	2.78158642
28	Hyperaldosteronism (HP:0000859)	2.77880674
29	Male infertility (HP:0003251)	2.77400120
30	Congenital ichthyosiform erythroderma (HP:0007431)	2.77238065
31	Hyperkalemia (HP:0002153)	2.77176281
32	Plantar hyperkeratosis (HP:0007556)	2.62965712
33	Chronic sinusitis (HP:0011109)	2.62534963
34	Alopecia of scalp (HP:0002293)	2.61940785
35	Recurrent otitis media (HP:0000403)	2.61616317
36	Palmar hyperkeratosis (HP:0010765)	2.57018390
37	Recurrent sinusitis (HP:0011108)	2.55583037
38	Thin bony cortex (HP:0002753)	2.50381443
39	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.48922076
40	Atelectasis (HP:0100750)	2.47191307
41	Woolly hair (HP:0002224)	2.32858279
42	Popliteal pterygium (HP:0009756)	2.27487567
43	Amelogenesis imperfecta (HP:0000705)	2.26974209
44	Hyponatremia (HP:0002902)	2.26507873
45	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.24629780
46	Alkalosis (HP:0001948)	2.20688802
47	Hemorrhage of the eye (HP:0011885)	2.18392780
48	Hypotrichosis (HP:0001006)	2.16732872
49	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	2.13340685
50	Tubular atrophy (HP:0000092)	2.12921423
51	Stridor (HP:0010307)	2.12739903
52	Fragile nails (HP:0001808)	2.12670717
53	Chronic otitis media (HP:0000389)	2.11457298
54	Abnormality of the distal phalanges of the toes (HP:0010182)	2.07942341
55	Oral leukoplakia (HP:0002745)	2.05354548
56	Abnormality of the dental root (HP:0006486)	2.03129329
57	Taurodontia (HP:0000679)	2.03129329
58	Abnormality of permanent molar morphology (HP:0011071)	2.03129329
59	Increased IgE level (HP:0003212)	1.98429431
60	Abdominal distention (HP:0003270)	1.98330854
61	Distal lower limb muscle weakness (HP:0009053)	1.96821414
62	Cystic liver disease (HP:0006706)	1.94168958
63	Abnormality of the salivary glands (HP:0010286)	1.93385941
64	Obstructive sleep apnea (HP:0002870)	1.90535300
65	Abnormality of molar (HP:0011077)	1.88773196
66	Abnormality of molar morphology (HP:0011070)	1.88773196
67	Curly hair (HP:0002212)	1.88051088
68	Dehydration (HP:0001944)	1.86752150
69	Occipital encephalocele (HP:0002085)	1.86733409
70	Bell-shaped thorax (HP:0001591)	1.83790848
71	Hydroxyprolinuria (HP:0003080)	1.81486631
72	Abnormality of proline metabolism (HP:0010907)	1.81486631
73	Corneal erosion (HP:0200020)	1.81129003
74	Spinal cord compression (HP:0002176)	1.80774779
75	Cervical subluxation (HP:0003308)	1.79678220
76	Bronchomalacia (HP:0002780)	1.79650369
77	Furrowed tongue (HP:0000221)	1.79457647
78	Aplasia/hypoplasia of the femur (HP:0005613)	1.79195449
79	Abnormality of the dental pulp (HP:0006479)	1.77765912
80	Abnormality of sodium homeostasis (HP:0010931)	1.76043809
81	Flattened epiphyses (HP:0003071)	1.75608771
82	Abnormality of small intestinal villus morphology (HP:0011472)	1.73494018
83	Villous atrophy (HP:0011473)	1.73494018
84	Metabolic alkalosis (HP:0200114)	1.71911895
85	Mildly elevated creatine phosphokinase (HP:0008180)	1.70966999
86	Abnormal vertebral ossification (HP:0100569)	1.68115916
87	Aplasia of the musculature (HP:0100854)	1.62018498
88	Short femoral neck (HP:0100864)	1.61496668
89	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.60740995
90	Tubulointerstitial nephritis (HP:0001970)	1.59386336
91	Erythroderma (HP:0001019)	1.57752041
92	Hyperphosphatemia (HP:0002905)	1.57314471
93	Widely patent fontanelles and sutures (HP:0004492)	1.56297104
94	Testicular atrophy (HP:0000029)	1.55055867
95	Hypoplasia of dental enamel (HP:0006297)	1.53688467
96	J-shaped sella turcica (HP:0002680)	1.53445408
97	Syncope (HP:0001279)	1.51745765
98	Nail dystrophy (HP:0008404)	1.51684743
99	Germ cell neoplasia (HP:0100728)	1.50442205
100	Adrenal overactivity (HP:0002717)	1.49840715

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	7.66925515
2	MAPK15	6.02503425
3	MST1R	4.80643178
4	TRIB3	3.65806947
5	MAPKAPK3	3.31004467
6	SIK1	2.92791163
7	RIPK1	2.31928163
8	ERN1	2.26174916
9	NME1	2.12926577
10	MST4	2.07103325
11	SMG1	2.00314774
12	EEF2K	1.96084084
13	MET	1.90816319
14	PTK6	1.81735425
15	PKN2	1.63919501
16	LMTK2	1.63641628
17	RPS6KB2	1.48632924
18	PIK3CA	1.46385121
19	STK24	1.46184975
20	FGFR4	1.32079141
21	EPHB1	1.31694891
22	MAP3K2	1.31476556
23	ACVR1B	1.29482551
24	MAP2K6	1.28124038
25	TESK1	1.27131721
26	PRKCI	1.25451268
27	MAP3K3	1.23993372
28	FER	1.17817800
29	GRK6	1.16489583
30	MUSK	1.09960893
31	WNK4	1.08351797
32	MAP2K2	1.04829391
33	ERBB2	1.01828811
34	STK39	0.98446097
35	MAP3K6	0.97558798
36	RPS6KA2	0.88101092
37	MARK2	0.87788305
38	CDC42BPA	0.87176195
39	TAOK1	0.87026206
40	PRKD2	0.86574685
41	PRKG2	0.85728097
42	PAK4	0.84205660
43	CHUK	0.84198687
44	ICK	0.81775998
45	EPHA3	0.79787096
46	TBK1	0.79257212
47	NEK6	0.77309167
48	PTK2	0.74848510
49	TNK2	0.72523415
50	MAP3K7	0.69048166
51	PDPK1	0.62915978
52	MATK	0.61308694
53	MAP3K12	0.60487647
54	TRPM7	0.59693462
55	PRKAA2	0.58836718
56	CSK	0.55080467
57	BMX	0.52622146
58	LRRK2	0.51553489
59	TLK1	0.51107883
60	MTOR	0.48770631
61	STK38	0.48597695
62	OXSR1	0.47892495
63	HIPK2	0.47220019
64	ILK	0.47208730
65	MAPKAPK2	0.46670245
66	RPS6KA6	0.45309970
67	IRAK1	0.44724632
68	RPS6KL1	0.44513097
69	RPS6KC1	0.44513097
70	EPHB2	0.43557075
71	GRK1	0.43421071
72	MYLK	0.42811606
73	FGFR3	0.42695682
74	IKBKE	0.41424714
75	DMPK	0.37654433
76	MAP3K1	0.36825838
77	ZAP70	0.35638985
78	RET	0.31971110
79	PRKD3	0.29181987
80	PRKCD	0.27816840
81	MAP3K11	0.26299602
82	PRKD1	0.25984553
83	PDGFRB	0.25931701
84	IKBKB	0.24941319
85	DDR2	0.24875421
86	IRAK3	0.24428457
87	PRKCZ	0.24324609
88	MAP3K10	0.24034845
89	MAPK8	0.22638826
90	STK38L	0.20812962
91	MAP2K1	0.20618619
92	CAMKK1	0.20524229
93	LATS1	0.20327170
94	DYRK1B	0.19646303
95	SRC	0.17676105
96	CAMK2G	0.17512825
97	SIK3	0.17177857
98	PTK2B	0.16966416
99	MAPKAPK5	0.16110745
100	MAPK11	0.15964675

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.98078408
2	Histidine metabolism_Homo sapiens_hsa00340	3.84019818
3	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	3.05430194
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.93998232
5	Chemical carcinogenesis_Homo sapiens_hsa05204	2.73393768
6	Phenylalanine metabolism_Homo sapiens_hsa00360	2.66550216
7	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.57930567
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.52361907
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.49519087
10	Caffeine metabolism_Homo sapiens_hsa00232	2.41760767
11	Fat digestion and absorption_Homo sapiens_hsa04975	2.15179145
12	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.98297487
13	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.91633715
14	Retinol metabolism_Homo sapiens_hsa00830	1.87027426
15	Sulfur metabolism_Homo sapiens_hsa00920	1.86880010
16	Tyrosine metabolism_Homo sapiens_hsa00350	1.83133228
17	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.74959505
18	Mineral absorption_Homo sapiens_hsa04978	1.69091036
19	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.67037351
20	Tight junction_Homo sapiens_hsa04530	1.65350804
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.63182702
22	Sphingolipid metabolism_Homo sapiens_hsa00600	1.61132976
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.54090020
24	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.52087849
25	Glutathione metabolism_Homo sapiens_hsa00480	1.51581589
26	Notch signaling pathway_Homo sapiens_hsa04330	1.48176875
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.44809449
28	Arginine biosynthesis_Homo sapiens_hsa00220	1.40939877
29	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.39669809
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.39426947
31	beta-Alanine metabolism_Homo sapiens_hsa00410	1.36090989
32	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.28533100
33	ABC transporters_Homo sapiens_hsa02010	1.25360442
34	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.25019495
35	Bile secretion_Homo sapiens_hsa04976	1.22069809
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.21745543
37	Pancreatic secretion_Homo sapiens_hsa04972	1.20822693
38	Glycerolipid metabolism_Homo sapiens_hsa00561	1.19999124
39	Sulfur relay system_Homo sapiens_hsa04122	1.19343775
40	Protein digestion and absorption_Homo sapiens_hsa04974	1.15710951
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.15455245
42	Fatty acid degradation_Homo sapiens_hsa00071	1.14915485
43	Hepatitis C_Homo sapiens_hsa05160	1.14446642
44	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.11862054
45	Other glycan degradation_Homo sapiens_hsa00511	1.09692329
46	PPAR signaling pathway_Homo sapiens_hsa03320	1.07000877
47	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.06789181
48	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.06432700
49	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.95254915
50	Arginine and proline metabolism_Homo sapiens_hsa00330	0.92758999
51	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.86714504
52	Insulin resistance_Homo sapiens_hsa04931	0.81456290
53	Renin-angiotensin system_Homo sapiens_hsa04614	0.80927902
54	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.80297080
55	Choline metabolism in cancer_Homo sapiens_hsa05231	0.79926251
56	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.79843830
57	Galactose metabolism_Homo sapiens_hsa00052	0.75137939
58	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.74918524
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74410528
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.64564672
61	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.62907359
62	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.61881984
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.53904213
64	Bladder cancer_Homo sapiens_hsa05219	0.49622783
65	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.48649452
66	VEGF signaling pathway_Homo sapiens_hsa04370	0.47605542
67	GnRH signaling pathway_Homo sapiens_hsa04912	0.42744181
68	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.41844581
69	Salivary secretion_Homo sapiens_hsa04970	0.40698144
70	Peroxisome_Homo sapiens_hsa04146	0.40110591
71	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.39175283
72	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.38638456
73	AMPK signaling pathway_Homo sapiens_hsa04152	0.37535560
74	Circadian rhythm_Homo sapiens_hsa04710	0.36941284
75	Thyroid cancer_Homo sapiens_hsa05216	0.36661630
76	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36315956
77	Taste transduction_Homo sapiens_hsa04742	0.35499420
78	Axon guidance_Homo sapiens_hsa04360	0.35377262
79	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.33959482
80	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.33541089
81	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.30995429
82	Estrogen signaling pathway_Homo sapiens_hsa04915	0.30412940
83	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.30305787
84	Lysosome_Homo sapiens_hsa04142	0.30022245
85	Insulin signaling pathway_Homo sapiens_hsa04910	0.29798707
86	Endocytosis_Homo sapiens_hsa04144	0.27756659
87	Adherens junction_Homo sapiens_hsa04520	0.27388338
88	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.23520426
89	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.22828849
90	Amoebiasis_Homo sapiens_hsa05146	0.21144250
91	Metabolic pathways_Homo sapiens_hsa01100	0.20734281
92	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.18399499
93	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.18229791
94	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.17677410
95	Hippo signaling pathway_Homo sapiens_hsa04390	0.16337942
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.15990756
97	Renin secretion_Homo sapiens_hsa04924	0.15837319
98	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.15615155
99	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.14001425
100	TNF signaling pathway_Homo sapiens_hsa04668	0.13668837

BICDL2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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