BID

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.20944914
2neutrophil activation involved in immune response (GO:0002283)5.09267113
3response to peptidoglycan (GO:0032494)5.08708145
4negative regulation of interleukin-12 production (GO:0032695)4.77292349
5positive regulation by symbiont of host defense response (GO:0052509)4.55913131
6modulation by symbiont of host defense response (GO:0052031)4.55913131
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.55913131
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.55913131
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.55913131
10modulation by symbiont of host immune response (GO:0052553)4.55913131
11DNA strand elongation involved in DNA replication (GO:0006271)4.48399992
12telomere maintenance via semi-conservative replication (GO:0032201)4.46890742
13positive regulation of gamma-delta T cell activation (GO:0046645)4.30922887
14DNA strand elongation (GO:0022616)4.27252260
15viral transcription (GO:0019083)4.20285968
16DNA deamination (GO:0045006)4.15921713
17translational termination (GO:0006415)4.07564107
18formation of translation preinitiation complex (GO:0001731)4.05871702
19macrophage activation involved in immune response (GO:0002281)3.96487504
20maturation of SSU-rRNA (GO:0030490)3.95668532
21telomere maintenance via recombination (GO:0000722)3.91627836
22ribosomal small subunit biogenesis (GO:0042274)3.87831612
23DNA replication initiation (GO:0006270)3.87442254
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.79252273
25translational elongation (GO:0006414)3.74468918
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.72100340
27negative regulation of cell killing (GO:0031342)3.72100340
28lipopolysaccharide-mediated signaling pathway (GO:0031663)3.65367666
29regulation of interferon-beta biosynthetic process (GO:0045357)3.62545447
30DNA unwinding involved in DNA replication (GO:0006268)3.62192910
31positive regulation of mast cell activation (GO:0033005)3.61166646
32ribosomal large subunit biogenesis (GO:0042273)3.58025235
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.55687771
34mitotic recombination (GO:0006312)3.54262304
35regulation of mast cell degranulation (GO:0043304)3.52809873
36translational initiation (GO:0006413)3.51253014
37detection of other organism (GO:0098543)3.51195201
38interferon-gamma-mediated signaling pathway (GO:0060333)3.51091053
39nucleobase biosynthetic process (GO:0046112)3.50641764
40neutrophil activation (GO:0042119)3.48687405
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.47894585
42granulocyte activation (GO:0036230)3.46132914
43cotranslational protein targeting to membrane (GO:0006613)3.45976486
44negative regulation of myeloid cell apoptotic process (GO:0033033)3.45539678
45myeloid cell activation involved in immune response (GO:0002275)3.44925320
46telomere maintenance via telomere lengthening (GO:0010833)3.44744847
47protein targeting to ER (GO:0045047)3.43887760
48positive regulation of mast cell degranulation (GO:0043306)3.42251523
49positive regulation of mast cell activation involved in immune response (GO:0033008)3.42251523
50DNA replication checkpoint (GO:0000076)3.40089240
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.39323903
52ribonucleoprotein complex biogenesis (GO:0022613)3.36273799
53leukocyte aggregation (GO:0070486)3.35412649
54positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.35374056
55detection of bacterium (GO:0016045)3.35313870
56folic acid-containing compound biosynthetic process (GO:0009396)3.34641638
57purine nucleobase biosynthetic process (GO:0009113)3.31660143
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.30007925
59response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.28973880
60response to host immune response (GO:0052572)3.28973880
61protein localization to endoplasmic reticulum (GO:0070972)3.25686606
62cellular extravasation (GO:0045123)3.24339533
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.23862001
64somatic hypermutation of immunoglobulin genes (GO:0016446)3.22704912
65somatic diversification of immune receptors via somatic mutation (GO:0002566)3.22704912
66viral life cycle (GO:0019058)3.21825642
67IMP biosynthetic process (GO:0006188)3.21119634
68regulation of mast cell activation involved in immune response (GO:0033006)3.21026728
69detection of molecule of bacterial origin (GO:0032490)3.19765841
70cellular protein complex disassembly (GO:0043624)3.18874678
71regulation of mast cell activation (GO:0033003)3.18542233
72microglial cell activation (GO:0001774)3.18390518
73regulation of interferon-alpha production (GO:0032647)3.17440743
74positive regulation of B cell differentiation (GO:0045579)3.16833503
75ribosome biogenesis (GO:0042254)3.13289769
76Arp2/3 complex-mediated actin nucleation (GO:0034314)3.12709572
77detection of external biotic stimulus (GO:0098581)3.12073165
78positive regulation of interferon-alpha production (GO:0032727)3.12057423
79antigen processing and presentation of endogenous antigen (GO:0019883)3.10842621
80antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.10158700
81antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.10158700
82positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.08125059
83cellular response to type I interferon (GO:0071357)3.07302434
84type I interferon signaling pathway (GO:0060337)3.07302434
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.02273947
86T-helper 1 type immune response (GO:0042088)3.00571647
87response to type I interferon (GO:0034340)2.99773462
88regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.97662546
89regulation of antigen processing and presentation (GO:0002577)2.96423730
90regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94844633
91rRNA processing (GO:0006364)2.94355193
92IMP metabolic process (GO:0046040)2.94091667
93regulation of myeloid leukocyte mediated immunity (GO:0002886)2.93492141
94NIK/NF-kappaB signaling (GO:0038061)2.91660986
95positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.91629908
96macrophage activation (GO:0042116)2.90478106
97response to muramyl dipeptide (GO:0032495)2.90192330
98pseudouridine synthesis (GO:0001522)2.90059092
99defense response to protozoan (GO:0042832)2.88836616
100negative regulation of cytokine production involved in immune response (GO:0002719)2.88788802
101response to host (GO:0075136)2.87844400
102response to host defenses (GO:0052200)2.87844400
103response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.87844400
104leukocyte degranulation (GO:0043299)2.87201295
105protein localization to kinetochore (GO:0034501)2.86255645
106positive regulation of antigen processing and presentation (GO:0002579)2.86174323
107regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.86076316
108response to interferon-beta (GO:0035456)2.85398647
109response to protozoan (GO:0001562)2.84745263
110antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.83614753
111rRNA metabolic process (GO:0016072)2.83585753
112mitotic nuclear envelope disassembly (GO:0007077)2.83382506
113protein complex disassembly (GO:0043241)2.80979812
114proteasome assembly (GO:0043248)2.80592338
115regulation of leukocyte degranulation (GO:0043300)2.80424163
116cellular response to interferon-gamma (GO:0071346)2.80293815
117CENP-A containing nucleosome assembly (GO:0034080)2.80153088
118antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.79443369
119positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.79337666
120negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.79117361
121positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.78822852
122ribosome assembly (GO:0042255)2.78160475
123translation (GO:0006412)2.77296303
124folic acid metabolic process (GO:0046655)2.76899850
125regulation of B cell apoptotic process (GO:0002902)2.76729469
126purine nucleotide salvage (GO:0032261)2.75896241
127regulation of B cell receptor signaling pathway (GO:0050855)2.75419863
128mature B cell differentiation involved in immune response (GO:0002313)2.74971854
129regulation of interleukin-12 production (GO:0032655)2.74746066
130detection of biotic stimulus (GO:0009595)2.74494524
131positive regulation of interferon-beta production (GO:0032728)2.74462235
132myeloid dendritic cell activation (GO:0001773)2.74293030
133regulation of gamma-delta T cell activation (GO:0046643)2.73528878
134chromatin remodeling at centromere (GO:0031055)2.73485011
135negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.72464924
136negative regulation of phagocytosis (GO:0050765)2.72157467
137B cell mediated immunity (GO:0019724)2.72120875
138immunoglobulin mediated immune response (GO:0016064)2.70809211
139response to interferon-gamma (GO:0034341)2.68831987
140transcription-coupled nucleotide-excision repair (GO:0006283)2.68812685
141DNA replication-dependent nucleosome organization (GO:0034723)2.66789363
142DNA replication-dependent nucleosome assembly (GO:0006335)2.66789363
143macromolecular complex disassembly (GO:0032984)2.66519606
144nuclear-transcribed mRNA catabolic process (GO:0000956)2.63577047
145regulation of protein heterodimerization activity (GO:0043497)2.63503216
146telomere maintenance (GO:0000723)2.63434467
147positive regulation of interleukin-17 production (GO:0032740)2.63195505
148telomere organization (GO:0032200)2.63121500
149regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.62901677
150positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.62102757
151anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.61480130
152regulation of dendritic cell antigen processing and presentation (GO:0002604)2.61263132
153regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.61044869
154cell cycle G1/S phase transition (GO:0044843)2.60756550
155G1/S transition of mitotic cell cycle (GO:0000082)2.60756550
156spliceosomal snRNP assembly (GO:0000387)2.60645824
157myeloid leukocyte activation (GO:0002274)2.60213549
158positive regulation of interleukin-10 production (GO:0032733)2.59799402
159regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.59424401
160positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.59288246
161membrane disassembly (GO:0030397)2.59047015
162nuclear envelope disassembly (GO:0051081)2.59047015
163DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.58657995
164somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.58178964
165isotype switching (GO:0045190)2.58178964
166somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.58178964
167neutrophil mediated immunity (GO:0002446)2.57604479
168purine deoxyribonucleotide catabolic process (GO:0009155)2.57468825
169positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.56271737
170negative regulation of ligase activity (GO:0051352)2.55749822
171negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.55749822
172regulation of interleukin-17 production (GO:0032660)2.55506755
173intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55201889
174signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55201889
175regulation of alpha-beta T cell proliferation (GO:0046640)2.55156479
176positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.54469242
177DNA replication-independent nucleosome organization (GO:0034724)2.53941099
178DNA replication-independent nucleosome assembly (GO:0006336)2.53941099
179signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.52159440
180signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.52159440
181signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.52159440
182cellular component biogenesis (GO:0044085)2.52154087
183mRNA catabolic process (GO:0006402)2.49973669
184RNA catabolic process (GO:0006401)2.49100702
185protein localization to chromosome, centromeric region (GO:0071459)2.48648701
186base-excision repair (GO:0006284)2.46991786
187respiratory burst (GO:0045730)2.46709308
188pentose-phosphate shunt (GO:0006098)2.46252252
189signal transduction involved in DNA damage checkpoint (GO:0072422)2.46041711
190signal transduction involved in DNA integrity checkpoint (GO:0072401)2.46041711

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.20788999
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.81339697
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.75593036
4E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82052802
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73388524
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.70374609
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.63429974
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.61810353
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58342110
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55059408
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50941345
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.43679223
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.41915510
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40833836
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34281967
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32445765
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31925194
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.29584061
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.18744109
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18221840
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16993177
22VDR_23849224_ChIP-Seq_CD4+_Human2.13577380
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13540389
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.09913660
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.07817525
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.07704406
27XRN2_22483619_ChIP-Seq_HELA_Human2.04047641
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02769234
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02111165
30* MYC_22102868_ChIP-Seq_BL_Human1.99912548
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98721576
32* SPI1_23127762_ChIP-Seq_K562_Human1.96654766
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.96389909
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.95247909
35* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94992076
36FOXP3_21729870_ChIP-Seq_TREG_Human1.91372057
37DCP1A_22483619_ChIP-Seq_HELA_Human1.83490783
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83143983
39* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83101380
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82338953
41VDR_21846776_ChIP-Seq_THP-1_Human1.76425654
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73400883
43* SPI1_23547873_ChIP-Seq_NB4_Human1.73214878
44* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71855676
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71810592
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.69809861
47GABP_19822575_ChIP-Seq_HepG2_Human1.68946664
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67619514
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66301218
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.65537049
51* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64854673
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.58852167
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57213741
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56210971
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.54471472
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52966095
57ELK1_19687146_ChIP-ChIP_HELA_Human1.52526525
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51681917
59TTF2_22483619_ChIP-Seq_HELA_Human1.49610178
60AR_21909140_ChIP-Seq_LNCAP_Human1.48771066
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47973799
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47249958
63CIITA_25753668_ChIP-Seq_RAJI_Human1.46563217
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46417929
65* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45012433
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44212721
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43871769
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.43166145
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.42939204
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.42197061
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40350496
72MAF_26560356_Chip-Seq_TH2_Human1.38736658
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37880721
74* BCL6_27268052_Chip-Seq_Bcells_Human1.35056331
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34627883
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34325916
77MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34116438
78* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33434674
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33332057
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32005571
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31931065
82* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29794999
83RUNX_20019798_ChIP-Seq_JUKART_Human1.29716508
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29558531
85TFEB_21752829_ChIP-Seq_HELA_Human1.28877063
86* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26229711
87* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25744999
88KDM5A_27292631_Chip-Seq_BREAST_Human1.25350977
89* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22573752
90GATA3_27048872_Chip-Seq_THYMUS_Human1.22534748
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21065776
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21010208
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20806501
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20406831
95* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19857292
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19493035
97GATA1_22025678_ChIP-Seq_K562_Human1.18032005
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17731300
99* RUNX1_22412390_ChIP-Seq_EML_Mouse1.17710398
100SCL_19346495_ChIP-Seq_HPC-7_Human1.16648100
101* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15832291
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15044598
103* GATA3_26560356_Chip-Seq_TH2_Human1.14201906
104* MYB_26560356_Chip-Seq_TH2_Human1.13245193
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12643514
106VDR_24787735_ChIP-Seq_THP-1_Human1.12600115
107* BCOR_27268052_Chip-Seq_Bcells_Human1.11856091
108ELF1_20517297_ChIP-Seq_JURKAT_Human1.11207088
109FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10709750
110MYB_26560356_Chip-Seq_TH1_Human1.09733308
111* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09248574
112* MAF_26560356_Chip-Seq_TH1_Human1.08368893
113ELK3_25401928_ChIP-Seq_HUVEC_Human1.06738593
114* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06728786
115GATA1_19941827_ChIP-Seq_MEL_Mouse1.05480752
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04946686
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03892590
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03664796
119LXR_22292898_ChIP-Seq_THP-1_Human1.03613087
120VDR_24763502_ChIP-Seq_THP-1_Human1.03601438
121* IRF8_27001747_Chip-Seq_BMDM_Mouse1.02930165
122BP1_19119308_ChIP-ChIP_Hs578T_Human1.02043955
123KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01855966
124* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01484265
125PU_27001747_Chip-Seq_BMDM_Mouse1.01255991
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01123470
127* UTX_26944678_Chip-Seq_JUKART_Human1.01010902
128CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01006430
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99851189
130SPI1_20517297_ChIP-Seq_HL60_Human0.99849733
131* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98992925
132SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98551013
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98422816
134PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97201448
135CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96150370
136CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94586788
137VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92479740
138CTCF_26484167_Chip-Seq_Bcells_Mouse0.91896103
139DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91847806
140MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89695072
141TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89473116
142BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87652304

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.92424606
2MP0010094_abnormal_chromosome_stability3.34491063
3MP0001835_abnormal_antigen_presentation3.34052424
4MP0002396_abnormal_hematopoietic_system3.29763347
5MP0004957_abnormal_blastocyst_morpholog3.00527937
6MP0003111_abnormal_nucleus_morphology2.85276124
7MP0003077_abnormal_cell_cycle2.80994992
8MP0008057_abnormal_DNA_replication2.57801159
9MP0009785_altered_susceptibility_to2.49294151
10MP0003436_decreased_susceptibility_to2.42783471
11MP0001800_abnormal_humoral_immune2.33740463
12MP0008058_abnormal_DNA_repair2.32082962
13MP0000685_abnormal_immune_system2.28842695
14* MP0009764_decreased_sensitivity_to2.25051562
15MP0005671_abnormal_response_to2.21220848
16MP0002398_abnormal_bone_marrow2.14026593
17MP0009333_abnormal_splenocyte_physiolog2.12987893
18MP0002452_abnormal_antigen_presenting2.12902684
19MP0000490_abnormal_crypts_of2.10449306
20MP0005025_abnormal_response_to2.06093376
21MP0008007_abnormal_cellular_replicative2.04962891
22MP0005000_abnormal_immune_tolerance2.04259370
23MP0003075_altered_response_to2.03170815
24MP0001545_abnormal_hematopoietic_system2.02619132
25MP0005397_hematopoietic_system_phenotyp2.02619132
26MP0000689_abnormal_spleen_morphology2.01356404
27MP0002420_abnormal_adaptive_immunity2.00096998
28MP0001819_abnormal_immune_cell1.98111812
29MP0002723_abnormal_immune_serum1.95832175
30MP0001853_heart_inflammation1.94851913
31MP0001790_abnormal_immune_system1.91709221
32MP0005387_immune_system_phenotype1.91709221
33MP0002419_abnormal_innate_immunity1.90086640
34MP0002148_abnormal_hypersensitivity_rea1.89488117
35MP0004808_abnormal_hematopoietic_stem1.88456965
36MP0003763_abnormal_thymus_physiology1.86952714
37MP0002722_abnormal_immune_system1.86775493
38MP0000716_abnormal_immune_system1.83198752
39MP0004510_myositis1.82405517
40MP0003300_gastrointestinal_ulcer1.76020165
41MP0010307_abnormal_tumor_latency1.75967712
42MP0002429_abnormal_blood_cell1.73581745
43MP0005464_abnormal_platelet_physiology1.72895179
44MP0003303_peritoneal_inflammation1.69878603
45MP0003806_abnormal_nucleotide_metabolis1.66477359
46MP0008260_abnormal_autophagy1.61684247
47MP0002019_abnormal_tumor_incidence1.60148675
48MP0002166_altered_tumor_susceptibility1.59707975
49MP0002405_respiratory_system_inflammati1.59538321
50MP0000858_altered_metastatic_potential1.59393509
51MP0010352_gastrointestinal_tract_polyps1.58911281
52MP0005174_abnormal_tail_pigmentation1.54126669
53MP0003186_abnormal_redox_activity1.49130956
54MP0005451_abnormal_body_composition1.45875987
55MP0000350_abnormal_cell_proliferation1.42847581
56MP0010155_abnormal_intestine_physiology1.42628983
57MP0000703_abnormal_thymus_morphology1.41462839
58MP0003172_abnormal_lysosome_physiology1.41460086
59* MP0001845_abnormal_inflammatory_respons1.40108683
60MP0008932_abnormal_embryonic_tissue1.39375665
61MP0006082_CNS_inflammation1.32583422
62MP0000465_gastrointestinal_hemorrhage1.31672174
63MP0002006_tumorigenesis1.30001970
64MP0005075_abnormal_melanosome_morpholog1.29852088
65MP0003724_increased_susceptibility_to1.29580656
66MP0003786_premature_aging1.26105473
67MP0003656_abnormal_erythrocyte_physiolo1.26052314
68* MP0000313_abnormal_cell_death1.25989003
69MP0001730_embryonic_growth_arrest1.25922046
70MP0009278_abnormal_bone_marrow1.17742631
71MP0005058_abnormal_lysosome_morphology1.17725879
72* MP0005166_decreased_susceptibility_to1.17248235
73MP0008469_abnormal_protein_level1.16544705
74MP0000604_amyloidosis1.15985232
75MP0005310_abnormal_salivary_gland1.15058134
76MP0006054_spinal_hemorrhage1.14854778
77MP0000343_altered_response_to1.10791085
78MP0005167_abnormal_blood-brain_barrier1.09744007
79MP0002998_abnormal_bone_remodeling1.09342575
80MP0002139_abnormal_hepatobiliary_system1.07568138
81MP0009379_abnormal_foot_pigmentation1.06217765
82MP0001873_stomach_inflammation1.02955590
83MP0002277_abnormal_respiratory_mucosa0.97642071
84MP0001533_abnormal_skeleton_physiology0.97313428
85MP0009840_abnormal_foam_cell0.95596830
86MP0003448_altered_tumor_morphology0.94756221
87MP0000358_abnormal_cell_content/0.94015450
88MP0003866_abnormal_defecation0.93398229
89MP0004947_skin_inflammation0.91731014
90MP0000015_abnormal_ear_pigmentation0.91195956
91MP0009765_abnormal_xenobiotic_induced0.90518747
92MP0005023_abnormal_wound_healing0.90117390
93MP0001663_abnormal_digestive_system0.89922526
94MP0002132_abnormal_respiratory_system0.89362398
95* MP0002080_prenatal_lethality0.86944365
96MP0002095_abnormal_skin_pigmentation0.83717217
97MP0001764_abnormal_homeostasis0.83281979
98MP0002138_abnormal_hepatobiliary_system0.82372862
99MP0002332_abnormal_exercise_endurance0.81671607
100MP0003183_abnormal_peptide_metabolism0.80810975
101MP0005164_abnormal_response_to0.80268561
102MP0003690_abnormal_glial_cell0.78540326
103MP0003221_abnormal_cardiomyocyte_apopto0.78121019
104MP0001697_abnormal_embryo_size0.77911689
105MP0003828_pulmonary_edema0.77682772
106MP0005319_abnormal_enzyme/_coenzyme0.76948136
107MP0005165_increased_susceptibility_to0.76878324
108MP0005390_skeleton_phenotype0.76651102
109* MP0006036_abnormal_mitochondrial_physio0.76124407
110MP0003191_abnormal_cellular_cholesterol0.75424673
111MP0004147_increased_porphyrin_level0.75175327
112MP0005584_abnormal_enzyme/coenzyme_acti0.75129218
113MP0009763_increased_sensitivity_to0.75100055
114MP0008874_decreased_physiological_sensi0.74971635
115MP0002254_reproductive_system_inflammat0.74927408
116MP0000477_abnormal_intestine_morphology0.71543593
117MP0008873_increased_physiological_sensi0.71379567
118MP0004883_abnormal_blood_vessel0.70796756
119MP0006035_abnormal_mitochondrial_morpho0.70112140
120* MP0000598_abnormal_liver_morphology0.69428383
121MP0008004_abnormal_stomach_pH0.69035544
122MP0005621_abnormal_cell_physiology0.67426819
123MP0003718_maternal_effect0.66044862
124MP0000371_diluted_coat_color0.65940471
125MP0001542_abnormal_bone_strength0.65929867
126MP0001851_eye_inflammation0.65347437
127MP0005384_cellular_phenotype0.65286449
128MP0001727_abnormal_embryo_implantation0.63589463
129MP0001672_abnormal_embryogenesis/_devel0.61817090
130MP0005380_embryogenesis_phenotype0.61817090
131MP0002877_abnormal_melanocyte_morpholog0.61547675
132MP0002933_joint_inflammation0.61345164
133MP0003795_abnormal_bone_structure0.60996197
134MP0002136_abnormal_kidney_physiology0.60872633
135MP0003453_abnormal_keratinocyte_physiol0.60534749
136MP0000249_abnormal_blood_vessel0.58992343
137MP0000609_abnormal_liver_physiology0.57519745
138MP0003195_calcinosis0.56206410

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.53086373
2Abnormality of liposaccharide metabolism (HP:0010968)4.53086373
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.53086373
4Abnormality of cells of the erythroid lineage (HP:0012130)4.48119740
5Abnormal number of erythroid precursors (HP:0012131)4.31473808
6Reticulocytopenia (HP:0001896)4.30409300
7Stomatitis (HP:0010280)4.30222534
8Recurrent abscess formation (HP:0002722)4.12310858
9Orchitis (HP:0100796)4.03713381
10Thrombocytosis (HP:0001894)3.95631741
11Retrobulbar optic neuritis (HP:0100654)3.91188726
12Optic neuritis (HP:0100653)3.91188726
13Elevated erythrocyte sedimentation rate (HP:0003565)3.62321175
14IgM deficiency (HP:0002850)3.60057565
15Recurrent bacterial skin infections (HP:0005406)3.57654651
16Increased IgM level (HP:0003496)3.48789365
17Aplastic anemia (HP:0001915)3.34576596
18Increased cerebral lipofuscin (HP:0011813)3.19863814
19Eczematoid dermatitis (HP:0000976)3.10397213
20Urticaria (HP:0001025)3.06957816
21Agnosia (HP:0010524)3.06247730
22Petechiae (HP:0000967)3.04900426
23Oral leukoplakia (HP:0002745)3.01821622
24Birth length less than 3rd percentile (HP:0003561)3.01028087
25Pallor (HP:0000980)2.97802727
26Chronic mucocutaneous candidiasis (HP:0002728)2.92623396
27Recurrent cutaneous fungal infections (HP:0011370)2.92623396
28Myositis (HP:0100614)2.87964402
29Macrocytic anemia (HP:0001972)2.85808353
30Recurrent bronchitis (HP:0002837)2.85048910
31Purpura (HP:0000979)2.80490838
32Increased neuronal autofluorescent lipopigment (HP:0002074)2.78937759
33Abnormality of the anterior horn cell (HP:0006802)2.78820053
34Degeneration of anterior horn cells (HP:0002398)2.78820053
35Loss of speech (HP:0002371)2.73404140
36Amyloidosis (HP:0011034)2.72766649
37Chronic otitis media (HP:0000389)2.69762150
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.68646880
39Chronic obstructive pulmonary disease (HP:0006510)2.67559629
40Obstructive lung disease (HP:0006536)2.67559629
41Dysostosis multiplex (HP:0000943)2.66014128
42Pulmonary infiltrates (HP:0002113)2.65193654
43Lymphoma (HP:0002665)2.63595943
44Cellulitis (HP:0100658)2.63516164
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.62413018
46Keratoconjunctivitis sicca (HP:0001097)2.61806833
47Recurrent viral infections (HP:0004429)2.59352736
48Mediastinal lymphadenopathy (HP:0100721)2.56457442
49Poikiloderma (HP:0001029)2.55622954
50Systemic lupus erythematosus (HP:0002725)2.55160942
51Reduced antithrombin III activity (HP:0001976)2.51619202
52Hepatosplenomegaly (HP:0001433)2.50798585
53Disinhibition (HP:0000734)2.50742777
54Hemoptysis (HP:0002105)2.50556328
55Abnormality of macrophages (HP:0004311)2.50267770
56Meningitis (HP:0001287)2.48441311
57Recurrent gram-negative bacterial infections (HP:0005420)2.47013190
58Keratoconjunctivitis (HP:0001096)2.45925427
59Pustule (HP:0200039)2.45867494
60Rough bone trabeculation (HP:0100670)2.44430933
6111 pairs of ribs (HP:0000878)2.44280810
62Abnormality of T cell physiology (HP:0011840)2.43761672
63IgG deficiency (HP:0004315)2.43229468
64Mutism (HP:0002300)2.43113456
65Myelodysplasia (HP:0002863)2.40959637
66Anorexia (HP:0002039)2.40070728
67Type I transferrin isoform profile (HP:0003642)2.40003456
68Gastrointestinal infarctions (HP:0005244)2.38816830
69Abnormality of cells of the lymphoid lineage (HP:0012140)2.38677635
70Recurrent fungal infections (HP:0002841)2.38492954
71Hypergammaglobulinemia (HP:0010702)2.36340544
72Lymphopenia (HP:0001888)2.34792008
73Autoimmune thrombocytopenia (HP:0001973)2.34655407
74Spontaneous hematomas (HP:0007420)2.34100466
75Multiple enchondromatosis (HP:0005701)2.32046873
76Hypertensive crisis (HP:0100735)2.29344888
77Autoimmune hemolytic anemia (HP:0001890)2.29160516
78Chromsome breakage (HP:0040012)2.28105974
79Poor head control (HP:0002421)2.26507421
80Abnormality of T cells (HP:0002843)2.24224261
81Progressive neurologic deterioration (HP:0002344)2.24044354
82Increased IgE level (HP:0003212)2.23694272
83Recurrent skin infections (HP:0001581)2.22526970
84Gingivitis (HP:0000230)2.22170589
85Bone marrow hypocellularity (HP:0005528)2.22149357
86Leukocytosis (HP:0001974)2.21742342
87Microretrognathia (HP:0000308)2.20426588
88B lymphocytopenia (HP:0010976)2.20158898
89Abnormality of B cell number (HP:0010975)2.20158898
90Abnormality of pyrimidine metabolism (HP:0004353)2.19529509
91Squamous cell carcinoma (HP:0002860)2.17630490
92Gangrene (HP:0100758)2.17528120
93Gingival bleeding (HP:0000225)2.16513753
94Abnormality of T cell number (HP:0011839)2.15788753
95Arterial thrombosis (HP:0004420)2.15067618
96Chest pain (HP:0100749)2.15054764
97Agammaglobulinemia (HP:0004432)2.14967564
98Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.14837543
99Decreased activity of mitochondrial respiratory chain (HP:0008972)2.14837543
100Pancytopenia (HP:0001876)2.14575754
101Polyneuropathy (HP:0001271)2.14224587
102Absent thumb (HP:0009777)2.13839130
103IgA deficiency (HP:0002720)2.13455204
104Vacuolated lymphocytes (HP:0001922)2.13180688
105Abnormality of iron homeostasis (HP:0011031)2.12466637
106Abnormality of chromosome stability (HP:0003220)2.11437229
107Abnormality of the preputium (HP:0100587)2.10472278
108T lymphocytopenia (HP:0005403)2.10123615
109Basal cell carcinoma (HP:0002671)2.09240106
110Colon cancer (HP:0003003)2.08458433
111Episodic fever (HP:0001954)2.08183302
112Vasculitis (HP:0002633)2.06765240
113Osteomyelitis (HP:0002754)2.06539632
114Premature graying of hair (HP:0002216)2.05285710
115Nasal polyposis (HP:0100582)2.03205294
116Leukopenia (HP:0001882)2.01273338
117Gastrointestinal stroma tumor (HP:0100723)2.01042551
118Pulmonary fibrosis (HP:0002206)2.00822955
119Abnormality of the heme biosynthetic pathway (HP:0010472)2.00473009
120Abnormality of the prostate (HP:0008775)2.00313253
121Abnormality of the pleura (HP:0002103)2.00239500
122Skin rash (HP:0000988)2.00239278
123Panhypogammaglobulinemia (HP:0003139)2.00178229
124Eosinophilia (HP:0001880)1.99577262
125Chromosomal breakage induced by crosslinking agents (HP:0003221)1.99177767
126Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98714921
127Abnormality of polysaccharide metabolism (HP:0011012)1.98714921
128Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98714921
129Selective tooth agenesis (HP:0001592)1.96048465
130Recurrent lower respiratory tract infections (HP:0002783)1.94895645
131Glomerulopathy (HP:0100820)1.94594006
132Hepatocellular necrosis (HP:0001404)1.93424327
133Pulmonary embolism (HP:0002204)1.92810379
134Amaurosis fugax (HP:0100576)1.91554584
135Entropion (HP:0000621)1.91465734
136Granulocytopenia (HP:0001913)1.91102689
137Inflammation of the large intestine (HP:0002037)1.90298547
138Recurrent pneumonia (HP:0006532)1.90180047
139Trismus (HP:0000211)1.89872208
140Cutaneous melanoma (HP:0012056)1.89286245
141Breast hypoplasia (HP:0003187)1.89071993
142Sepsis (HP:0100806)1.88628672
143Abnormality of reticulocytes (HP:0004312)1.88191971
144Nausea (HP:0002018)1.88078834
145Skin ulcer (HP:0200042)1.86389338
146Encephalitis (HP:0002383)1.85798438
147Atrophy/Degeneration involving motor neurons (HP:0007373)1.85418221
148Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85309225
149Abnormal protein N-linked glycosylation (HP:0012347)1.85309225
150Abnormal protein glycosylation (HP:0012346)1.85309225
151Abnormal glycosylation (HP:0012345)1.85309225
152Personality changes (HP:0000751)1.84968062
153Prolonged bleeding time (HP:0003010)1.83974079
154Abnormal mitochondria in muscle tissue (HP:0008316)1.83629302
155Increased serum ferritin (HP:0003281)1.83164032
156Mitochondrial inheritance (HP:0001427)1.82712590
157Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82551060
158Gastrointestinal inflammation (HP:0004386)1.82435018
159Abnormal trabecular bone morphology (HP:0100671)1.81816320
160Epistaxis (HP:0000421)1.81760296
161Recurrent sinusitis (HP:0011108)1.79337756

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.18509011
2EIF2AK13.07940098
3MAP4K13.07468082
4WEE12.97773511
5NME22.96847359
6CDC72.52202324
7STK162.45003964
8BLK2.42732389
9KIT2.24742738
10EIF2AK32.24261455
11SCYL22.09972935
12PIM22.08832299
13BMPR21.96577062
14FLT31.84538060
15TESK21.81080267
16NEK21.79341774
17ACVR1B1.73712872
18RPS6KA41.72967232
19TAOK21.70714897
20TSSK61.67447159
21TEC1.64960070
22CSF1R1.61775384
23GRK71.61632827
24IRAK41.60579347
25MAP3K31.58721850
26BTK1.57073341
27VRK11.56362647
28BRSK21.55179328
29ZAP701.52943968
30STK101.50609609
31VRK21.48515599
32TYK21.47594096
33FGR1.45703122
34SYK1.40039418
35TNK21.38317265
36TLK11.37772889
37KDR1.36463714
38RPS6KB21.35691391
39EEF2K1.33589373
40ERN11.31286177
41LRRK21.29358143
42ATR1.26474442
43CDK71.25019968
44TBK11.24664057
45ARAF1.24070413
46PIM11.23934461
47MAP2K31.21201202
48GRK61.20750724
49DYRK31.13905903
50PRPF4B1.12128923
51PLK11.11322540
52SRPK11.10959959
53PAK41.10892173
54TAOK31.10084698
55NEK11.06963619
56JAK31.04651449
57CDK41.02661189
58AURKB1.01985789
59LYN1.01124773
60MAPKAPK31.01044814
61MARK30.98709925
62JAK20.98365321
63MATK0.97282276
64IRAK20.97112612
65MAP3K120.96134198
66TXK0.95907811
67TGFBR20.95654237
68TAOK10.95359694
69MAP3K110.95081560
70MAP3K130.94952536
71MAP3K80.94304824
72TTK0.93166801
73MAP3K140.90918476
74SIK30.90568412
75TGFBR10.86581978
76IRAK30.86230276
77PASK0.85122509
78MAP3K100.84575218
79MAP3K10.83866241
80ITK0.83154696
81STK40.82615336
82IKBKB0.82084111
83EIF2AK20.80404715
84JAK10.80383269
85AURKA0.80089055
86MAP4K20.79496150
87MAP3K50.79412671
88MST40.79285042
89CLK10.77561350
90PLK40.76332790
91MOS0.74844546
92LCK0.74068560
93TESK10.73784639
94CDK190.73770637
95CHEK20.73157855
96ZAK0.71386484
97CSK0.71299583
98RIPK40.70663259
99ABL20.67949660
100ADRBK20.65954192
101MKNK10.65788873
102BCKDK0.65143618
103BRSK10.64685484
104IKBKE0.64212908
105PKN20.62744263
106DAPK10.60477437
107LIMK10.59668712
108CDK80.57934021
109CCNB10.57613248
110IRAK10.55219598
111YES10.54599122
112CDK60.53337368
113FES0.52899512
114HCK0.52001250
115CHEK10.51854006
116* CSNK2A20.51450154
117* CSNK2A10.50450623
118PLK30.49535067
119CHUK0.47837320
120PRKCI0.47698851
121DAPK30.47634141
122CAMKK20.46455067
123PAK10.46383286
124PDK10.45581514
125PRKCQ0.45252611
126RPS6KA60.44640739
127RAF10.44394870
128MAP3K60.44007357
129RPS6KA50.42906833
130MAPK40.41541445
131GRK50.41156936
132DAPK20.40116000
133MAPKAPK20.40101005
134ABL10.39721156
135PRKCD0.39554592
136DDR20.39261852
137EPHB10.38253009
138CDK20.37922865
139MAP2K60.32374186
140ALK0.32026356
141PDPK10.31983272
142PIK3CG0.31358204
143FYN0.31291396
144KSR20.26402327
145SMG10.25520242

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.83636171
2Mismatch repair_Homo sapiens_hsa034303.90233401
3Ribosome_Homo sapiens_hsa030103.74831426
4Proteasome_Homo sapiens_hsa030503.15030775
5Base excision repair_Homo sapiens_hsa034103.08679326
6Autoimmune thyroid disease_Homo sapiens_hsa053203.00081530
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84464905
8Homologous recombination_Homo sapiens_hsa034402.60642160
9RNA polymerase_Homo sapiens_hsa030202.59910493
10Nucleotide excision repair_Homo sapiens_hsa034202.55848381
11Type I diabetes mellitus_Homo sapiens_hsa049402.49120147
12Spliceosome_Homo sapiens_hsa030402.43047876
13Rheumatoid arthritis_Homo sapiens_hsa053232.42662439
14One carbon pool by folate_Homo sapiens_hsa006702.36647483
15Pyrimidine metabolism_Homo sapiens_hsa002402.33999327
16RNA transport_Homo sapiens_hsa030132.10326695
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00231878
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89843118
19Cell cycle_Homo sapiens_hsa041101.85546360
20Primary immunodeficiency_Homo sapiens_hsa053401.81316641
21* Viral myocarditis_Homo sapiens_hsa054161.74174232
22Non-homologous end-joining_Homo sapiens_hsa034501.69431817
23Antigen processing and presentation_Homo sapiens_hsa046121.56915373
24Fanconi anemia pathway_Homo sapiens_hsa034601.52111495
25Pentose phosphate pathway_Homo sapiens_hsa000301.43077014
26* p53 signaling pathway_Homo sapiens_hsa041151.31563795
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30260654
28TNF signaling pathway_Homo sapiens_hsa046681.23017941
29Leishmaniasis_Homo sapiens_hsa051401.21566301
30Herpes simplex infection_Homo sapiens_hsa051681.20187646
31Oxidative phosphorylation_Homo sapiens_hsa001901.20132128
32Legionellosis_Homo sapiens_hsa051341.19692438
33RNA degradation_Homo sapiens_hsa030181.15665245
34Epstein-Barr virus infection_Homo sapiens_hsa051691.13617106
35African trypanosomiasis_Homo sapiens_hsa051431.10781102
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.10254344
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.10091464
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.06563556
39Chemokine signaling pathway_Homo sapiens_hsa040621.04001285
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.03856076
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01188824
42Hematopoietic cell lineage_Homo sapiens_hsa046401.01065205
43Folate biosynthesis_Homo sapiens_hsa007901.00511118
44Purine metabolism_Homo sapiens_hsa002301.00070473
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99433458
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96843496
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95918550
48Collecting duct acid secretion_Homo sapiens_hsa049660.95856316
49B cell receptor signaling pathway_Homo sapiens_hsa046620.95471668
50Other glycan degradation_Homo sapiens_hsa005110.95046351
51Basal transcription factors_Homo sapiens_hsa030220.95008221
52Measles_Homo sapiens_hsa051620.94558634
53Shigellosis_Homo sapiens_hsa051310.92594016
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92112598
55Parkinsons disease_Homo sapiens_hsa050120.92011047
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91458663
57Sulfur relay system_Homo sapiens_hsa041220.91164077
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90339611
59Systemic lupus erythematosus_Homo sapiens_hsa053220.85647048
60* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84524959
61Biosynthesis of amino acids_Homo sapiens_hsa012300.80480053
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.80346791
63Viral carcinogenesis_Homo sapiens_hsa052030.74987227
64T cell receptor signaling pathway_Homo sapiens_hsa046600.74826989
65Allograft rejection_Homo sapiens_hsa053300.74097378
66Hepatitis C_Homo sapiens_hsa051600.73246269
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.72668113
68* Apoptosis_Homo sapiens_hsa042100.72134190
69Selenocompound metabolism_Homo sapiens_hsa004500.69049118
70mRNA surveillance pathway_Homo sapiens_hsa030150.68217546
71Glutathione metabolism_Homo sapiens_hsa004800.66519436
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65388538
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65049921
74* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65009687
75Protein export_Homo sapiens_hsa030600.62497861
76Renin-angiotensin system_Homo sapiens_hsa046140.62217026
77Influenza A_Homo sapiens_hsa051640.61626463
78N-Glycan biosynthesis_Homo sapiens_hsa005100.61181110
79Pertussis_Homo sapiens_hsa051330.58922931
80Hepatitis B_Homo sapiens_hsa051610.58748682
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58154053
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54635509
83Carbon metabolism_Homo sapiens_hsa012000.53992179
84Staphylococcus aureus infection_Homo sapiens_hsa051500.53559145
85* Tuberculosis_Homo sapiens_hsa051520.53493185
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53245829
87Asthma_Homo sapiens_hsa053100.53087120
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52674059
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52667478
90Platelet activation_Homo sapiens_hsa046110.51701072
91Osteoclast differentiation_Homo sapiens_hsa043800.51191100
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50894758
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48856460
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48707480
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48095164
96Lysosome_Homo sapiens_hsa041420.46109652
97Malaria_Homo sapiens_hsa051440.45572203
98HTLV-I infection_Homo sapiens_hsa051660.44842843
99Galactose metabolism_Homo sapiens_hsa000520.44657615
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.43743682
101Sulfur metabolism_Homo sapiens_hsa009200.43145040
102Acute myeloid leukemia_Homo sapiens_hsa052210.43074830
103Vibrio cholerae infection_Homo sapiens_hsa051100.41438135
104Graft-versus-host disease_Homo sapiens_hsa053320.41391665
105Alzheimers disease_Homo sapiens_hsa050100.41103083
106Bladder cancer_Homo sapiens_hsa052190.40555367
107Phagosome_Homo sapiens_hsa041450.39127930
108Pancreatic cancer_Homo sapiens_hsa052120.37954414
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36688373
110Thyroid cancer_Homo sapiens_hsa052160.36046139
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35195019
112Salmonella infection_Homo sapiens_hsa051320.33957717
113Huntingtons disease_Homo sapiens_hsa050160.33605340
114Fructose and mannose metabolism_Homo sapiens_hsa000510.33426532
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33271852
116Toxoplasmosis_Homo sapiens_hsa051450.33047663
117Endocytosis_Homo sapiens_hsa041440.31873569
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31822172
119Small cell lung cancer_Homo sapiens_hsa052220.31136440
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30868715
121Caffeine metabolism_Homo sapiens_hsa002320.29275273
122Vitamin B6 metabolism_Homo sapiens_hsa007500.28386117
123* Sphingolipid signaling pathway_Homo sapiens_hsa040710.27928491
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.27690183
125* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26878566
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26611342
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26184548
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25749282
129Metabolic pathways_Homo sapiens_hsa011000.25021478
130VEGF signaling pathway_Homo sapiens_hsa043700.22265855
131Chronic myeloid leukemia_Homo sapiens_hsa052200.16639004
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16155788
133Non-small cell lung cancer_Homo sapiens_hsa052230.15475217
134HIF-1 signaling pathway_Homo sapiens_hsa040660.14697860
135Fatty acid elongation_Homo sapiens_hsa000620.14379238

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »