BIK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)8.37955424
2transcription from mitochondrial promoter (GO:0006390)7.55312513
3embryonic process involved in female pregnancy (GO:0060136)7.10955786
4replication fork processing (GO:0031297)7.08144895
5DNA deamination (GO:0045006)6.22575817
6oxidative demethylation (GO:0070989)6.19165254
7regulation of integrin activation (GO:0033623)6.08638396
8establishment of apical/basal cell polarity (GO:0035089)6.01074136
9maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.66101765
10rRNA modification (GO:0000154)5.42874732
11poly(A)+ mRNA export from nucleus (GO:0016973)5.32974863
12mitochondrial DNA metabolic process (GO:0032042)5.14241853
13DNA strand renaturation (GO:0000733)5.13076142
14establishment of monopolar cell polarity (GO:0061162)5.11889570
15establishment or maintenance of monopolar cell polarity (GO:0061339)5.11889570
16negative regulation of fatty acid biosynthetic process (GO:0045717)5.08672455
17ribosomal small subunit biogenesis (GO:0042274)4.88656121
18somatic hypermutation of immunoglobulin genes (GO:0016446)4.80246632
19somatic diversification of immune receptors via somatic mutation (GO:0002566)4.80246632
20negative regulation of transcription by competitive promoter binding (GO:0010944)4.74486265
21glutamine family amino acid biosynthetic process (GO:0009084)4.63211658
22ribosome assembly (GO:0042255)4.58922500
23rRNA methylation (GO:0031167)4.45223353
24embryonic placenta development (GO:0001892)4.44077943
25autophagic vacuole assembly (GO:0000045)4.37180275
26mitotic metaphase plate congression (GO:0007080)4.36331771
27activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.33697101
28sulfur amino acid catabolic process (GO:0000098)4.30789440
29chaperone-mediated protein transport (GO:0072321)4.26584767
30negative regulation of cell cycle arrest (GO:0071157)4.26563872
31cellular response to ATP (GO:0071318)4.26315535
32negative regulation of JAK-STAT cascade (GO:0046426)4.21887929
33regulation of G0 to G1 transition (GO:0070316)4.19198411
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.17833548
35viral mRNA export from host cell nucleus (GO:0046784)4.17669984
36mitotic G1 DNA damage checkpoint (GO:0031571)4.08858203
37ribosome biogenesis (GO:0042254)4.08767018
38meiotic chromosome segregation (GO:0045132)4.07314231
39mRNA cleavage (GO:0006379)4.06189391
40ribonucleoprotein complex biogenesis (GO:0022613)4.05159999
41regulation of sister chromatid cohesion (GO:0007063)3.86098046
42negative regulation of protein oligomerization (GO:0032460)3.84839011
43base-excision repair, AP site formation (GO:0006285)3.83263671
44positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.82455177
45positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.82455177
46positive regulation of mitotic sister chromatid separation (GO:1901970)3.82455177
47termination of RNA polymerase III transcription (GO:0006386)3.82318819
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.82318819
49regulation of translational fidelity (GO:0006450)3.80710707
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.80151461
51regulation of mitochondrial translation (GO:0070129)3.76764840
52negative regulation of Ras GTPase activity (GO:0034261)3.75424051
53alkaloid metabolic process (GO:0009820)3.73570203
54base-excision repair (GO:0006284)3.68810334
55dosage compensation (GO:0007549)3.68774242
56spliceosomal tri-snRNP complex assembly (GO:0000244)3.68276667
57mitotic G1/S transition checkpoint (GO:0044819)3.67611831
58rRNA processing (GO:0006364)3.65930834
59pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.64352628
60DNA integration (GO:0015074)3.62513748
61mitotic sister chromatid segregation (GO:0000070)3.61118170
62formation of translation preinitiation complex (GO:0001731)3.61086644
63male meiosis I (GO:0007141)3.57190324
64negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.56655914
65G1 DNA damage checkpoint (GO:0044783)3.55882421
66convergent extension (GO:0060026)3.54473778
67embryonic camera-type eye development (GO:0031076)3.53806002
68positive regulation by host of viral transcription (GO:0043923)3.51838778
69rRNA metabolic process (GO:0016072)3.51528702
70ribosomal large subunit biogenesis (GO:0042273)3.47905271
71negative regulation of epidermal cell differentiation (GO:0045605)3.47396677
72DNA double-strand break processing (GO:0000729)3.45824317
73establishment of protein localization to mitochondrial membrane (GO:0090151)3.45443589
74meiosis I (GO:0007127)3.45049481
75non-recombinational repair (GO:0000726)3.43785585
76double-strand break repair via nonhomologous end joining (GO:0006303)3.43785585
77ventricular cardiac muscle cell development (GO:0055015)3.43537475
78metaphase plate congression (GO:0051310)3.43346242
79cellular response to zinc ion (GO:0071294)3.43196476
80viral transcription (GO:0019083)3.39780037
81attachment of spindle microtubules to kinetochore (GO:0008608)3.39063232
82protein targeting to mitochondrion (GO:0006626)3.38233719
83negative regulation of mRNA processing (GO:0050686)3.37087577
84* regulation of protein homooligomerization (GO:0032462)3.37066674
85labyrinthine layer development (GO:0060711)3.36786465
86maturation of 5.8S rRNA (GO:0000460)3.35748934
87intestinal epithelial cell development (GO:0060576)3.35274449
88regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.32396910
89very-low-density lipoprotein particle assembly (GO:0034379)3.32295554
90positive regulation of receptor recycling (GO:0001921)3.31618386
91pseudouridine synthesis (GO:0001522)3.30411306
92translational termination (GO:0006415)3.30217865
93face development (GO:0060324)3.28695237
94GDP-mannose metabolic process (GO:0019673)3.26967494
95regulation of double-strand break repair via homologous recombination (GO:0010569)3.26248070
96tRNA methylation (GO:0030488)3.25729816
97trophectodermal cell differentiation (GO:0001829)3.25363709
98chaperone mediated protein folding requiring cofactor (GO:0051085)3.24116011
99mitochondrial RNA metabolic process (GO:0000959)3.20701742
100rRNA transcription (GO:0009303)3.18671818
101maturation of SSU-rRNA (GO:0030490)3.18320171
102negative regulation of mRNA metabolic process (GO:1903312)3.18311383
103regulation of spindle organization (GO:0090224)3.18124841
104deoxyribonucleotide biosynthetic process (GO:0009263)3.17942891
105ribosomal small subunit assembly (GO:0000028)3.17768934
106apoptotic process involved in morphogenesis (GO:0060561)3.16946520
107translational elongation (GO:0006414)3.16553733
108translational initiation (GO:0006413)3.16069127
109telomere maintenance via semi-conservative replication (GO:0032201)3.15713844
110negative regulation of fatty acid metabolic process (GO:0045922)3.15648352
111kinetochore assembly (GO:0051382)3.14676235
112activation of Rac GTPase activity (GO:0032863)3.14224290
113glial cell migration (GO:0008347)3.13775466
114protein K6-linked ubiquitination (GO:0085020)3.13539238
115cellular component biogenesis (GO:0044085)3.13039790
116positive regulation of DNA repair (GO:0045739)3.11232110
117mitotic chromosome condensation (GO:0007076)3.11099703
118positive regulation of circadian rhythm (GO:0042753)3.10573814
119histone H4-K12 acetylation (GO:0043983)3.09484854
120anatomical structure regression (GO:0060033)3.08638019
121polyamine biosynthetic process (GO:0006596)3.07670682
122DNA replication initiation (GO:0006270)3.06321813
123response to UV-C (GO:0010225)3.05772511
124pyrimidine nucleotide catabolic process (GO:0006244)3.05452566
125nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.04203676
126nodal signaling pathway (GO:0038092)3.04175535
127positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03776048
128translation (GO:0006412)3.03250363
129mitochondrial fusion (GO:0008053)3.01275021
130nucleotide-excision repair, DNA gap filling (GO:0006297)3.00841906
131positive regulation of developmental pigmentation (GO:0048087)2.99609406
132negative regulation of RNA splicing (GO:0033119)2.99262116
133negative regulation of epidermis development (GO:0045683)2.98610464
134SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.98550403
135resolution of meiotic recombination intermediates (GO:0000712)2.97820388
136establishment of protein localization to mitochondrion (GO:0072655)2.97629939
137anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97445828
138regulation of hippo signaling (GO:0035330)2.97019142
139regulation of double-strand break repair (GO:2000779)2.95672684
140protein localization to mitochondrion (GO:0070585)2.95484225
141skeletal muscle tissue regeneration (GO:0043403)2.94642114
142protein retention in ER lumen (GO:0006621)2.93236161
143regulation of gene silencing by RNA (GO:0060966)2.93193994
144regulation of posttranscriptional gene silencing (GO:0060147)2.93193994
145regulation of gene silencing by miRNA (GO:0060964)2.93193994
146glandular epithelial cell development (GO:0002068)2.93048927
147sister chromatid segregation (GO:0000819)2.92941688
148regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92145667
149pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.92067436
150cotranslational protein targeting to membrane (GO:0006613)2.91492013
151protein targeting to ER (GO:0045047)2.88936774
152negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.87563148
153negative regulation of response to food (GO:0032096)2.87210972
154negative regulation of appetite (GO:0032099)2.87210972
155intestinal cholesterol absorption (GO:0030299)2.86080872
156negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.85215316
157negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.84697391
158negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84407791
159regulation of podosome assembly (GO:0071801)2.83625754
160L-ascorbic acid metabolic process (GO:0019852)2.82679100
161viral life cycle (GO:0019058)2.82489510
162positive regulation of chromosome segregation (GO:0051984)2.81785124
163DNA topological change (GO:0006265)2.81499630
164regulation of transforming growth factor beta2 production (GO:0032909)2.80542853
165regulation of RNA export from nucleus (GO:0046831)2.79255193
166regulation of cell size (GO:0008361)2.78638418
167positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.78232004
168regulation of cardioblast differentiation (GO:0051890)2.77498087
169establishment of protein localization to endoplasmic reticulum (GO:0072599)2.77202370
170transcription elongation from RNA polymerase II promoter (GO:0006368)2.73647479
171positive regulation of cytokinesis (GO:0032467)2.73050302
172maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.72737823
173proteasome assembly (GO:0043248)2.72134797
174negative regulation of heart rate (GO:0010459)2.72106352
175ncRNA processing (GO:0034470)2.71239528
176protein localization to endoplasmic reticulum (GO:0070972)2.71195900
177mitochondrial DNA replication (GO:0006264)2.70880233
178DNA unwinding involved in DNA replication (GO:0006268)2.70489533
179termination of RNA polymerase II transcription (GO:0006369)2.70156691
180protein localization to chromosome, centromeric region (GO:0071459)2.66182620
181positive regulation of ligase activity (GO:0051351)2.64906124
182nucleobase-containing small molecule interconversion (GO:0015949)2.64526097
183transcription from RNA polymerase III promoter (GO:0006383)2.62400443
184snRNA transcription (GO:0009301)2.59698511
185DNA strand elongation (GO:0022616)2.58218945
186RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.57978722
187negative regulation of retinoic acid receptor signaling pathway (GO:0048387)14.8861129
188regulation of retinoic acid receptor signaling pathway (GO:0048385)12.8030130
189proline biosynthetic process (GO:0006561)10.6307666

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.27950384
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.99244199
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79778274
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.30490876
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.28350402
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.18170500
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.18170500
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.18170500
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.08418636
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.01809230
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.93872625
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.92127917
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.77482906
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.58866489
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50359463
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49714110
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47343692
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.35196638
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.29136340
20SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.27354915
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21953646
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.16838023
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.16373742
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.13643521
25* RXR_22158963_ChIP-Seq_LIVER_Mouse2.12085372
26XRN2_22483619_ChIP-Seq_HELA_Human2.10566892
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10067543
28POU5F1_16518401_ChIP-PET_MESCs_Mouse2.05258712
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.03808259
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.99649578
31DCP1A_22483619_ChIP-Seq_HELA_Human1.99525948
32NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.98385654
33NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.95889276
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.93344906
35VDR_21846776_ChIP-Seq_THP-1_Human1.91735911
36VDR_23849224_ChIP-Seq_CD4+_Human1.87805551
37TCF3_18692474_ChIP-Seq_MESCs_Mouse1.87464884
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86657758
39TTF2_22483619_ChIP-Seq_HELA_Human1.84885004
40* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.80919784
41LXR_22292898_ChIP-Seq_THP-1_Human1.79577723
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.76836185
43NANOG_21062744_ChIP-ChIP_HESCs_Human1.76055730
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74877770
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74754539
46PU.1_20513432_ChIP-Seq_Bcells_Mouse1.73256023
47FOXP3_21729870_ChIP-Seq_TREG_Human1.72365100
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.72205878
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68038499
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67983180
51AR_21909140_ChIP-Seq_LNCAP_Human1.67476639
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.67217044
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.66807686
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61858566
55ZNF263_19887448_ChIP-Seq_K562_Human1.61146894
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.59203312
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58426100
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.57429652
59* RACK7_27058665_Chip-Seq_MCF-7_Human1.55022945
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54289075
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53951375
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.53107296
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52789326
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51481590
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49071031
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.48964422
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48120518
68NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.48020216
69RXRA_24833708_ChIP-Seq_LIVER_Mouse1.46639943
70ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.45899370
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45531761
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44796679
73* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.44400637
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43448063
75* LXR_22158963_ChIP-Seq_LIVER_Mouse1.41899098
76* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39694088
77* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39572357
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36881794
79MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36583574
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35504996
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34783331
82POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.34711606
83SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34431616
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34343126
85CIITA_25753668_ChIP-Seq_RAJI_Human1.34095068
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32797161
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32626052
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31576092
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31279437
90JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28302167
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28098651
92RARB_24833708_ChIP-Seq_LIVER_Mouse1.27656197
93E2F1_21310950_ChIP-Seq_MCF-7_Human1.26818074
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26628692
95NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.26026761
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25335837
97ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23927386
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23461277
99SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22013265
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21221677
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21150489
102SPI1_26923725_Chip-Seq_HPCs_Mouse1.20312978
103NANOG_18692474_ChIP-Seq_MESCs_Mouse1.19878288
104MYC_22102868_ChIP-Seq_BL_Human1.19816674
105SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19320969
106* ETS1_21867929_ChIP-Seq_TH2_Mouse1.18821643
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18076438
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17593394
109RARA_24833708_ChIP-Seq_LIVER_Mouse1.17135343
110SOX2_18692474_ChIP-Seq_MESCs_Mouse1.16972027
111CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15439516
112ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12571802
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12388213
114POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12183820
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11756859
116GABP_19822575_ChIP-Seq_HepG2_Human1.11426458
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11239865
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11188585
119MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10984023
120PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10389727
121TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10266551
122OCT4_18692474_ChIP-Seq_MEFs_Mouse1.09933154
123EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09737556
124ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09474978
125HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09155733
126NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07372118
127PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06878195
128ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06591686
129ELF5_23300383_ChIP-Seq_T47D_Human1.06151039
130ELK3_25401928_ChIP-Seq_HUVEC_Human1.05771949
131SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05393375
132CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05286683
133TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05191144
134KDM5A_27292631_Chip-Seq_BREAST_Human1.05132811
135YY1_21170310_ChIP-Seq_MESCs_Mouse1.05095589
136POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04866187
137THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02770556
138KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01920391
139KAP1_27257070_Chip-Seq_ESCs_Mouse1.01781039
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01731818
141YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01317128
142TFEB_21752829_ChIP-Seq_HELA_Human1.00874966
143TP63_17297297_ChIP-ChIP_HaCaT_Human1.00856170
144NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00231826
145ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99891343
146BCOR_27268052_Chip-Seq_Bcells_Human0.99056139
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99007131
148* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97463992
149CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95799147
150ELK1_19687146_ChIP-ChIP_HELA_Human0.95178820
151MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93143206
152SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91808068
153PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91558744
154EGR1_19374776_ChIP-ChIP_THP-1_Human0.89808402
155ATF3_27146783_Chip-Seq_COLON_Human0.89800300
156CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89059945
157* FOXP1_21924763_ChIP-Seq_HESCs_Human0.87205604
158HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86424521
159TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85675753
160* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84478220
161KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83467239
162* CTCF_21964334_Chip-Seq_Bcells_Human0.83453971

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity6.04713405
2MP0008057_abnormal_DNA_replication4.99030985
3MP0005423_abnormal_somatic_nervous4.51649980
4MP0010030_abnormal_orbit_morphology3.99832062
5MP0008260_abnormal_autophagy3.88314388
6MP0009278_abnormal_bone_marrow3.85110157
7MP0005171_absent_coat_pigmentation3.73614738
8MP0005451_abnormal_body_composition3.23675313
9MP0004233_abnormal_muscle_weight3.11401517
10MP0009379_abnormal_foot_pigmentation3.02225179
11MP0005085_abnormal_gallbladder_physiolo2.76496880
12MP0008995_early_reproductive_senescence2.67728640
13MP0010234_abnormal_vibrissa_follicle2.62607208
14MP0005365_abnormal_bile_salt2.57624786
15MP0009333_abnormal_splenocyte_physiolog2.38579039
16MP0002009_preneoplasia2.37099398
17MP0003890_abnormal_embryonic-extraembry2.28189744
18MP0002653_abnormal_ependyma_morphology2.27913291
19MP0010094_abnormal_chromosome_stability2.08337644
20MP0003453_abnormal_keratinocyte_physiol2.04793116
21MP0008877_abnormal_DNA_methylation2.01976493
22MP0003283_abnormal_digestive_organ2.00984311
23MP0004957_abnormal_blastocyst_morpholog1.91463058
24MP0006072_abnormal_retinal_apoptosis1.90856556
25MP0003786_premature_aging1.88845788
26MP0006036_abnormal_mitochondrial_physio1.88379340
27MP0003119_abnormal_digestive_system1.85128851
28MP0004133_heterotaxia1.84797698
29MP0002139_abnormal_hepatobiliary_system1.80952531
30MP0005397_hematopoietic_system_phenotyp1.74473383
31MP0001545_abnormal_hematopoietic_system1.74473383
32MP0008007_abnormal_cellular_replicative1.74088678
33MP0002249_abnormal_larynx_morphology1.70715368
34MP0003806_abnormal_nucleotide_metabolis1.67490317
35MP0000579_abnormal_nail_morphology1.66237034
36MP0002269_muscular_atrophy1.62234390
37MP0002086_abnormal_extraembryonic_tissu1.61769120
38MP0004264_abnormal_extraembryonic_tissu1.59571232
39MP0000015_abnormal_ear_pigmentation1.51901347
40MP0003718_maternal_effect1.51743043
41MP0000678_abnormal_parathyroid_gland1.50253902
42MP0002282_abnormal_trachea_morphology1.49661518
43MP0001697_abnormal_embryo_size1.46944870
44MP0002160_abnormal_reproductive_system1.46612561
45MP0006035_abnormal_mitochondrial_morpho1.41776423
46MP0002084_abnormal_developmental_patter1.41071930
47MP0005360_urolithiasis1.40703953
48MP0005076_abnormal_cell_differentiation1.40686454
49MP0000358_abnormal_cell_content/1.40422482
50MP0010352_gastrointestinal_tract_polyps1.40260091
51MP0002163_abnormal_gland_morphology1.39725945
52MP0003693_abnormal_embryo_hatching1.39133608
53MP0000639_abnormal_adrenal_gland1.37541942
54MP0010307_abnormal_tumor_latency1.36880131
55MP0000462_abnormal_digestive_system1.35603195
56MP0003111_abnormal_nucleus_morphology1.35599601
57MP0001346_abnormal_lacrimal_gland1.34844636
58MP0002085_abnormal_embryonic_tissue1.32692562
59MP0005501_abnormal_skin_physiology1.30296015
60MP0005380_embryogenesis_phenotype1.28475642
61MP0001672_abnormal_embryogenesis/_devel1.28475642
62MP0008058_abnormal_DNA_repair1.27473523
63MP0006292_abnormal_olfactory_placode1.26925438
64MP0000313_abnormal_cell_death1.25967603
65MP0004197_abnormal_fetal_growth/weight/1.25631569
66MP0003567_abnormal_fetal_cardiomyocyte1.25310963
67MP0001881_abnormal_mammary_gland1.24961213
68MP0000470_abnormal_stomach_morphology1.24629918
69MP0001873_stomach_inflammation1.23994657
70MP0008932_abnormal_embryonic_tissue1.23259450
71MP0003938_abnormal_ear_development1.21888898
72MP0004019_abnormal_vitamin_homeostasis1.21523470
73MP0002877_abnormal_melanocyte_morpholog1.16447832
74MP0005266_abnormal_metabolism1.15529273
75MP0002796_impaired_skin_barrier1.14122271
76MP0003646_muscle_fatigue1.13908805
77MP0003077_abnormal_cell_cycle1.13246352
78MP0005389_reproductive_system_phenotype1.08888717
79MP0003123_paternal_imprinting1.08847841
80MP0003828_pulmonary_edema1.07967387
81MP0005330_cardiomyopathy1.07752615
82MP0001730_embryonic_growth_arrest1.06692377
83MP0000490_abnormal_crypts_of1.06409318
84MP0005058_abnormal_lysosome_morphology1.05632693
85MP0001293_anophthalmia1.03766296
86MP0003984_embryonic_growth_retardation1.03529197
87MP0002254_reproductive_system_inflammat1.03031902
88MP0002127_abnormal_cardiovascular_syste1.01486359
89MP0003943_abnormal_hepatobiliary_system1.01064822
90MP0003763_abnormal_thymus_physiology1.01029340
91MP0002088_abnormal_embryonic_growth/wei0.99783260
92MP0003186_abnormal_redox_activity0.99672797
93MP0003315_abnormal_perineum_morphology0.99628134
94MP0002111_abnormal_tail_morphology0.95572532
95MP0000371_diluted_coat_color0.94514190
96MP0000750_abnormal_muscle_regeneration0.93593625
97MP0002098_abnormal_vibrissa_morphology0.93249511
98MP0001340_abnormal_eyelid_morphology0.92343695
99MP0010630_abnormal_cardiac_muscle0.92101656
100MP0000537_abnormal_urethra_morphology0.91701934
101MP0002932_abnormal_joint_morphology0.91513313
102MP0000350_abnormal_cell_proliferation0.90422677
103MP0000627_abnormal_mammary_gland0.90305754
104MP0002277_abnormal_respiratory_mucosa0.89126746
105MP0005647_abnormal_sex_gland0.88500758
106MP0005395_other_phenotype0.88209570
107MP0000477_abnormal_intestine_morphology0.87786760
108MP0002080_prenatal_lethality0.87565586
109MP0000762_abnormal_tongue_morphology0.87384451
110MP0005379_endocrine/exocrine_gland_phen0.86260807
111MP0003699_abnormal_female_reproductive0.85644295
112MP0005174_abnormal_tail_pigmentation0.85526567
113MP0003137_abnormal_impulse_conducting0.82815360
114MP0005332_abnormal_amino_acid0.82422342
115MP0002019_abnormal_tumor_incidence0.82028527
116MP0002060_abnormal_skin_morphology0.81206580
117MP0009115_abnormal_fat_cell0.80462048
118MP0001666_abnormal_nutrient_absorption0.80261385
119MP0001216_abnormal_epidermal_layer0.80210675
120MP0004381_abnormal_hair_follicle0.80003876
121MP0003191_abnormal_cellular_cholesterol0.79317350
122MP0001145_abnormal_male_reproductive0.78458289
123MP0005220_abnormal_exocrine_pancreas0.77114028
124MP0005075_abnormal_melanosome_morpholog0.76311999
125MP0009053_abnormal_anal_canal0.75707357
126MP0000609_abnormal_liver_physiology0.75041942
127MP0001119_abnormal_female_reproductive0.74873170
128MP0005645_abnormal_hypothalamus_physiol0.74685490
129MP0003172_abnormal_lysosome_physiology0.74232732
130MP0003566_abnormal_cell_adhesion0.72808252
131MP0003045_fibrosis0.72378276
132MP0003935_abnormal_craniofacial_develop0.71194266
133MP0000653_abnormal_sex_gland0.70920249
134MP0008875_abnormal_xenobiotic_pharmacok0.70588543
135MP0004808_abnormal_hematopoietic_stem0.69231911
136MP0002970_abnormal_white_adipose0.69054175
137MP0005670_abnormal_white_adipose0.69043482
138MP0005310_abnormal_salivary_gland0.68679785
139MP0002332_abnormal_exercise_endurance0.68335895
140MP0000685_abnormal_immune_system0.67972131
141MP0002210_abnormal_sex_determination0.66165730
142MP0003755_abnormal_palate_morphology0.65146920
143MP0001919_abnormal_reproductive_system0.64581871
144MP0002132_abnormal_respiratory_system0.64395339
145MP0000598_abnormal_liver_morphology0.63515804
146MP0004185_abnormal_adipocyte_glucose0.61902881
147MP0001929_abnormal_gametogenesis0.61835158
148MP0005319_abnormal_enzyme/_coenzyme0.61403524
149MP0002148_abnormal_hypersensitivity_rea0.59797331
150MP0005666_abnormal_adipose_tissue0.59668774
151MP0010155_abnormal_intestine_physiology0.59480137
152MP0003698_abnormal_male_reproductive0.57433037
153MP0001849_ear_inflammation0.57320450
154MP0002161_abnormal_fertility/fecundity0.56479290
155MP0008789_abnormal_olfactory_epithelium0.56209127
156MP0005083_abnormal_biliary_tract0.55456717
157MP0000613_abnormal_salivary_gland0.54236169

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.29314265
2Pustule (HP:0200039)4.97592722
3Birth length less than 3rd percentile (HP:0003561)4.75810181
4Hypochromic microcytic anemia (HP:0004840)4.75433496
5Facial hemangioma (HP:0000329)4.74197028
6Alopecia of scalp (HP:0002293)4.47847564
7Turricephaly (HP:0000262)4.46628790
8Annular pancreas (HP:0001734)4.42691287
9Increased IgM level (HP:0003496)4.41974534
10Rectovaginal fistula (HP:0000143)4.40536393
11Rectal fistula (HP:0100590)4.40536393
12Male infertility (HP:0003251)4.33943191
13Concave nail (HP:0001598)4.31647025
14Poikiloderma (HP:0001029)4.18102525
15Vaginal fistula (HP:0004320)4.13065475
16Microvesicular hepatic steatosis (HP:0001414)4.12948512
17Double outlet right ventricle (HP:0001719)4.08167479
18Congenital malformation of the right heart (HP:0011723)4.08167479
19Carpal bone hypoplasia (HP:0001498)3.96290296
20Intestinal fistula (HP:0100819)3.95501710
21Ureteral duplication (HP:0000073)3.94168522
22Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.91952143
23Ulnar bowing (HP:0003031)3.89902006
24Pancreatic islet-cell hyperplasia (HP:0004510)3.80273872
25Tongue fasciculations (HP:0001308)3.78652530
26Intestinal atresia (HP:0011100)3.77566426
27Abnormal hemoglobin (HP:0011902)3.74124000
28Muscle fibrillation (HP:0010546)3.66464416
29Short humerus (HP:0005792)3.51580147
30Abnormality of the fetal cardiovascular system (HP:0010948)3.42526283
31Abnormal umbilical cord blood vessels (HP:0011403)3.42526283
32Single umbilical artery (HP:0001195)3.42526283
33Coronal craniosynostosis (HP:0004440)3.42400132
34Aplasia/hypoplasia of the humerus (HP:0006507)3.39516527
35Large for gestational age (HP:0001520)3.36765385
36Reticulocytopenia (HP:0001896)3.36223079
37Orthostatic hypotension (HP:0001278)3.35311503
38Microretrognathia (HP:0000308)3.34976811
39Multiple enchondromatosis (HP:0005701)3.28708901
40Posterior subcapsular cataract (HP:0007787)3.28168291
41Patent foramen ovale (HP:0001655)3.27185208
42Polycythemia (HP:0001901)3.22864735
43Abnormal pancreas size (HP:0012094)3.20614450
44Absent radius (HP:0003974)3.18663179
45Aplasia/hypoplasia of the uterus (HP:0008684)3.16876313
46Anteriorly placed anus (HP:0001545)3.13621949
47Urinary glycosaminoglycan excretion (HP:0003541)3.13410442
48Mucopolysacchariduria (HP:0008155)3.13410442
49Hypergonadotropic hypogonadism (HP:0000815)3.12947055
50Abnormality of the aortic arch (HP:0012303)3.12895847
51Progressive muscle weakness (HP:0003323)3.10340870
52Chromosomal breakage induced by crosslinking agents (HP:0003221)3.08006024
53Aplasia involving forearm bones (HP:0009822)2.97777759
54Absent forearm bone (HP:0003953)2.97777759
55Abnormality of cells of the erythroid lineage (HP:0012130)2.97766422
56Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.97384170
57Vertebral hypoplasia (HP:0008417)2.97384170
58Dysautonomia (HP:0002459)2.96409054
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.93699840
60Abnormality of polysaccharide metabolism (HP:0011012)2.93699840
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.93699840
62Pili torti (HP:0003777)2.93384073
63Asymmetric septal hypertrophy (HP:0001670)2.92356328
64Truncus arteriosus (HP:0001660)2.90887580
65Capillary hemangiomas (HP:0005306)2.88687444
66Abnormality of male internal genitalia (HP:0000022)2.86816009
67Abnormality of endocrine pancreas physiology (HP:0012093)2.84169198
68Abnormality of the pancreatic islet cells (HP:0006476)2.84169198
69Absent thumb (HP:0009777)2.83373619
70Trismus (HP:0000211)2.82738794
71Squamous cell carcinoma (HP:0002860)2.82543120
72Cleft eyelid (HP:0000625)2.81810478
73Sparse eyelashes (HP:0000653)2.76621203
74Growth hormone excess (HP:0000845)2.74643870
75Alacrima (HP:0000522)2.73290338
76Diaphragmatic weakness (HP:0009113)2.68351312
77Hypoplasia of the uterus (HP:0000013)2.66968759
78Type I transferrin isoform profile (HP:0003642)2.66717372
79Abnormal number of erythroid precursors (HP:0012131)2.66476012
80Absent rod-and cone-mediated responses on ERG (HP:0007688)2.64936217
81Abnormality of the umbilical cord (HP:0010881)2.64839873
82Patellar aplasia (HP:0006443)2.64064247
83Horseshoe kidney (HP:0000085)2.62359994
84Facial cleft (HP:0002006)2.60129395
85Choanal stenosis (HP:0000452)2.59882922
86Reduced antithrombin III activity (HP:0001976)2.59832121
87Ketoacidosis (HP:0001993)2.58721211
88Abnormal spermatogenesis (HP:0008669)2.57505313
89Breast hypoplasia (HP:0003187)2.57439403
90Testicular atrophy (HP:0000029)2.55614922
91Hypochromic anemia (HP:0001931)2.55505258
92Abnormality of aromatic amino acid family metabolism (HP:0004338)2.55325761
93Chromsome breakage (HP:0040012)2.54118001
94Aplasia of the musculature (HP:0100854)2.53474310
95Rough bone trabeculation (HP:0100670)2.53359350
96Popliteal pterygium (HP:0009756)2.51898003
97Congenital hip dislocation (HP:0001374)2.50739099
98Hypercortisolism (HP:0001578)2.49644614
99Premature ovarian failure (HP:0008209)2.48344147
100Hamartoma (HP:0010566)2.48255354
101Dysostosis multiplex (HP:0000943)2.45919275
102Hypotrichosis (HP:0001006)2.44916984
103Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.43878606
104Hypobetalipoproteinemia (HP:0003563)2.41879961
105Abnormality of the preputium (HP:0100587)2.39316730
106Premature skin wrinkling (HP:0100678)2.39155002
107Sparse lateral eyebrow (HP:0005338)2.36986639
108Broad alveolar ridges (HP:0000187)2.36347114
109Aplasia/Hypoplasia of the patella (HP:0006498)2.35858378
110Increased CSF lactate (HP:0002490)2.35175851
111Progressive external ophthalmoplegia (HP:0000590)2.33475096
112Hypokinesia (HP:0002375)2.33156103
113Ragged-red muscle fibers (HP:0003200)2.32866785
114Bifid uvula (HP:0000193)2.31155516
115Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29472646
116Short chin (HP:0000331)2.29252400
117Chronic sinusitis (HP:0011109)2.27011758
118Chronic bronchitis (HP:0004469)2.26976070
119Increased serum lactate (HP:0002151)2.26593485
120Amniotic constriction ring (HP:0009775)2.24466934
121Abnormality of placental membranes (HP:0011409)2.24466934
122Glossoptosis (HP:0000162)2.21482009
123Basal cell carcinoma (HP:0002671)2.21401119
124Joint stiffness (HP:0001387)2.21360274
125Absent/shortened dynein arms (HP:0200106)2.20606323
126Dynein arm defect of respiratory motile cilia (HP:0012255)2.20606323
127Short 1st metacarpal (HP:0010034)2.18565394
128Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.18565394
129Azoospermia (HP:0000027)2.17773282
130Vertebral fusion (HP:0002948)2.16578302
131Shawl scrotum (HP:0000049)2.16557052
132Albinism (HP:0001022)2.15468893
133Abnormal hair laboratory examination (HP:0003328)2.14272734
134Bowed forearm bones (HP:0003956)2.13343779
135Bowing of the arm (HP:0006488)2.13343779
136Gastrointestinal atresia (HP:0002589)2.11163477
137Redundant skin (HP:0001582)2.09830583
138Abnormal respiratory motile cilium physiology (HP:0012261)2.09004638
139Intrahepatic cholestasis (HP:0001406)2.08292631
140Duplicated collecting system (HP:0000081)2.07155896
141Median cleft lip (HP:0000161)2.06952629
142IgA deficiency (HP:0002720)2.05025448
143Cerebral aneurysm (HP:0004944)2.03432992
144Aplasia/Hypoplasia involving the musculature (HP:0001460)2.03430130
145Agammaglobulinemia (HP:0004432)2.03233399
146Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02804036
147Short thumb (HP:0009778)2.02620269
148Volvulus (HP:0002580)2.02601584
149Generalized amyotrophy (HP:0003700)2.02330699
150Rhinitis (HP:0012384)1.99955346
151Hypoplasia of the pons (HP:0012110)1.99268246
152Split hand (HP:0001171)1.98300953
153Abnormality of the 1st metacarpal (HP:0010009)1.97970020
154Selective tooth agenesis (HP:0001592)1.97880744
155Lower limb hyperreflexia (HP:0002395)1.97862655
156Abnormalities of placenta or umbilical cord (HP:0001194)1.97463726
157Acute hepatic failure (HP:0006554)1.96601539
158Hypotelorism (HP:0000601)1.94660549
159Abnormality of the renal collecting system (HP:0004742)1.93454213
160Premature graying of hair (HP:0002216)1.92818646
161Hypoplasia of the radius (HP:0002984)1.91766450
162Abnormality of the pons (HP:0007361)1.90728536
163Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90719686
164Abnormal protein N-linked glycosylation (HP:0012347)1.90719686
165Abnormal protein glycosylation (HP:0012346)1.90719686
166Abnormal glycosylation (HP:0012345)1.90719686
167Abnormal trabecular bone morphology (HP:0100671)1.90253497
168Ketosis (HP:0001946)1.89947798
169Myopathic facies (HP:0002058)1.88768608
170Decreased lacrimation (HP:0000633)1.88759957
171Hypoglycemic coma (HP:0001325)1.88583239
172Progressive hearing impairment (HP:0001730)1.87994101
173Acute lymphatic leukemia (HP:0006721)1.87551098
174Bilateral sensorineural hearing impairment (HP:0008619)1.87186442
175Subcapsular cataract (HP:0000523)1.86864868
176Mitochondrial inheritance (HP:0001427)1.86478766
177Bulbar palsy (HP:0001283)1.86015358
178Abnormal mitochondria in muscle tissue (HP:0008316)1.85924036
179Dysphonia (HP:0001618)1.85468119
180Pendular nystagmus (HP:0012043)1.83965137
181Death in infancy (HP:0001522)1.82919047
182Lactic acidosis (HP:0003128)1.82419602
183Abnormal ciliary motility (HP:0012262)1.82279929
184Delayed CNS myelination (HP:0002188)1.81389316
185Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81078485
186Hepatocellular necrosis (HP:0001404)1.80070838
187External ophthalmoplegia (HP:0000544)1.79718131
188Abnormal respiratory epithelium morphology (HP:0012253)1.79063714
189Abnormal respiratory motile cilium morphology (HP:0005938)1.79063714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.59883041
2MAPK155.52792878
3MAP3K65.17725840
4BUB15.09734215
5DDR24.57483666
6MST44.14440774
7NME23.43098013
8MAP3K113.41869899
9SRPK13.35135807
10STK163.22159133
11TESK23.10189826
12PINK13.08135185
13PBK2.83142429
14TYRO32.72362161
15MATK2.69340031
16VRK22.62300972
17FGR2.53566188
18PDK22.27906210
19SMG12.27544964
20PRKD22.21301669
21NME12.18609759
22DAPK12.09504588
23CSK2.06141171
24DYRK1B2.05463613
25BRSK12.03729676
26PDGFRA2.01628388
27BMX1.93797128
28MST1R1.91057059
29UHMK11.84857291
30TRIM281.82977751
31PIM21.82524827
32AKT31.80120291
33EIF2AK31.75577461
34LATS21.72668990
35TRPM71.70059984
36CDK71.59646521
37YES11.56598166
38NUAK11.43645728
39NEK61.35304210
40CDC71.34993640
41LATS11.30393809
42STK38L1.29311863
43TLK11.25262410
44PHKG21.24883187
45PHKG11.24883187
46TESK11.24758179
47PIM11.24501642
48MAPK111.23386199
49STK101.21768416
50CDC42BPA1.19932594
51CDK61.19273576
52EPHA21.16618649
53LRRK21.09521281
54RPS6KL11.09394084
55RPS6KC11.09394084
56ABL21.08329866
57GSK3A1.07548600
58ERBB31.05799087
59PLK31.05050036
60VRK11.04645115
61CHEK21.03656720
62EIF2AK11.00930216
63WEE10.98344375
64MAP3K80.97681471
65STK40.97453306
66SCYL20.96583438
67PLK10.95659309
68HIPK20.95313987
69RPS6KA60.95219083
70DYRK30.91298347
71ZAK0.91126829
72MAP3K20.86670581
73TRIB30.85089591
74BCKDK0.83168137
75MAP3K120.82957328
76PRKAA10.81068493
77MARK30.79540729
78CDK190.78773201
79MUSK0.75804247
80PAK40.75072819
81MAP2K20.73458286
82PAK10.69933002
83ILK0.69149791
84MAP3K100.69117807
85MTOR0.68347323
86IRAK30.67302980
87PTK20.64193749
88RPS6KA10.64055612
89ARAF0.59704370
90TAF10.58905025
91STK30.57356893
92DYRK20.56336947
93CDK80.55913796
94RPS6KB20.55620821
95ERBB40.54857223
96BRAF0.54769790
97TAOK20.54052815
98RPS6KA40.52672047
99STK390.52618031
100RAF10.51281231
101TEC0.50368828
102NEK20.49764392
103MAP3K90.49169274
104PRPF4B0.49124937
105MAPKAPK30.49014162
106KDR0.47560023
107AKT20.47207981
108PRKAA20.47172821
109IKBKB0.44730828
110EEF2K0.44445832
111MAP3K30.42126017
112EGFR0.41319059
113MET0.40003578
114CAMK2G0.40001878
115TAOK10.39814735
116CDK120.37984513
117CDK40.37037778
118CSNK1G10.36792542
119AURKA0.36426788
120FLT30.36180757
121CDK20.35991540
122MAPK30.35940476
123ATR0.35645193
124STK240.35406833
125CDK10.33600779
126* CSNK2A10.32286002
127EIF2AK20.31865073
128MAPK10.30593546
129MELK0.30154628
130CSNK1A10.30129126
131CHUK0.29905524
132PDGFRB0.29594629
133AURKB0.29534681
134MAPKAPK20.29242465
135CSNK1E0.28937808
136RPS6KB10.28278979
137DMPK0.27689825
138PLK40.27064078
139NEK10.26400345
140ATM0.26275680
141RPS6KA50.25749106
142ALK0.25520698
143RIPK10.25282201
144CDK90.24090504
145BTK0.23700198
146BMPR20.23677294
147TIE10.23606997
148MAP2K10.23121417
149OBSCN0.22877302
150PRKCI0.22605802
151CHEK10.21772643
152SIK10.21228951
153BRSK20.20558948
154MAPK140.20174956
155CAMK2B0.19488404
156TTK0.18822515
157STK380.18697976
158MAPK40.18435976
159JAK20.17710844
160LYN0.17595265
161CSNK2A20.17243129
162MAPK100.16854650
163PRKD10.16453053
164PRKCZ0.16308767

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.89795214
2Ribosome_Homo sapiens_hsa030104.65113681
3Mismatch repair_Homo sapiens_hsa034303.90423237
4RNA polymerase_Homo sapiens_hsa030203.82456876
5Base excision repair_Homo sapiens_hsa034103.79483369
6Regulation of autophagy_Homo sapiens_hsa041403.45736596
7Proteasome_Homo sapiens_hsa030503.37379113
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.82183522
9DNA replication_Homo sapiens_hsa030302.63068073
10Pyrimidine metabolism_Homo sapiens_hsa002402.59018587
11Arginine and proline metabolism_Homo sapiens_hsa003302.29710686
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.27195550
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.25916267
14Circadian rhythm_Homo sapiens_hsa047102.22616211
15Arginine biosynthesis_Homo sapiens_hsa002202.12536209
16Fatty acid metabolism_Homo sapiens_hsa012122.08037733
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.99705219
18Biosynthesis of amino acids_Homo sapiens_hsa012301.92504301
19Folate biosynthesis_Homo sapiens_hsa007901.91376909
20Sulfur metabolism_Homo sapiens_hsa009201.85179755
21Sulfur relay system_Homo sapiens_hsa041221.82260640
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75095779
23Huntingtons disease_Homo sapiens_hsa050161.68407364
24Hippo signaling pathway_Homo sapiens_hsa043901.68320408
25Nucleotide excision repair_Homo sapiens_hsa034201.65460093
26Notch signaling pathway_Homo sapiens_hsa043301.61917399
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.60815464
28Adherens junction_Homo sapiens_hsa045201.53552608
29Parkinsons disease_Homo sapiens_hsa050121.52424353
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51968859
31Homologous recombination_Homo sapiens_hsa034401.49387033
32TGF-beta signaling pathway_Homo sapiens_hsa043501.48165680
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45408537
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.39828538
35mTOR signaling pathway_Homo sapiens_hsa041501.39812157
36RNA transport_Homo sapiens_hsa030131.39692272
37p53 signaling pathway_Homo sapiens_hsa041151.38883639
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38431997
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38204174
40Lysine degradation_Homo sapiens_hsa003101.35974493
41Hedgehog signaling pathway_Homo sapiens_hsa043401.35775307
42mRNA surveillance pathway_Homo sapiens_hsa030151.35500186
43Oxidative phosphorylation_Homo sapiens_hsa001901.33822896
44Fanconi anemia pathway_Homo sapiens_hsa034601.33371800
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31085817
46Cell cycle_Homo sapiens_hsa041101.28625677
47Selenocompound metabolism_Homo sapiens_hsa004501.24695720
48Bladder cancer_Homo sapiens_hsa052191.23336966
49Protein export_Homo sapiens_hsa030601.21239408
50Tryptophan metabolism_Homo sapiens_hsa003801.20509654
51Non-homologous end-joining_Homo sapiens_hsa034501.17146485
52Purine metabolism_Homo sapiens_hsa002301.17114990
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16579590
54Longevity regulating pathway - mammal_Homo sapiens_hsa042111.14022728
55Spliceosome_Homo sapiens_hsa030401.10280373
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09756538
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07709804
58Fatty acid degradation_Homo sapiens_hsa000710.99929648
59Epstein-Barr virus infection_Homo sapiens_hsa051690.99634731
60Fructose and mannose metabolism_Homo sapiens_hsa000510.98313881
61Glutathione metabolism_Homo sapiens_hsa004800.93045007
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92519495
63Herpes simplex infection_Homo sapiens_hsa051680.92500575
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92303878
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90368376
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89172491
67Galactose metabolism_Homo sapiens_hsa000520.88704809
68Viral carcinogenesis_Homo sapiens_hsa052030.87273464
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85513932
70Systemic lupus erythematosus_Homo sapiens_hsa053220.84375414
71N-Glycan biosynthesis_Homo sapiens_hsa005100.79940650
72Tight junction_Homo sapiens_hsa045300.78673729
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77979404
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.77545194
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.77092644
76Pentose phosphate pathway_Homo sapiens_hsa000300.76262342
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75430404
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73059314
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72751119
80Basal cell carcinoma_Homo sapiens_hsa052170.72246885
81Sphingolipid metabolism_Homo sapiens_hsa006000.70887797
82Propanoate metabolism_Homo sapiens_hsa006400.70766498
83Wnt signaling pathway_Homo sapiens_hsa043100.70633808
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.70319391
85Peroxisome_Homo sapiens_hsa041460.69675895
86Shigellosis_Homo sapiens_hsa051310.68412981
87One carbon pool by folate_Homo sapiens_hsa006700.68387211
88Thyroid cancer_Homo sapiens_hsa052160.63695535
89Alzheimers disease_Homo sapiens_hsa050100.63257094
90Oocyte meiosis_Homo sapiens_hsa041140.61309083
91VEGF signaling pathway_Homo sapiens_hsa043700.58542126
92Fatty acid elongation_Homo sapiens_hsa000620.58244118
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57974356
94Pyruvate metabolism_Homo sapiens_hsa006200.57305225
95Starch and sucrose metabolism_Homo sapiens_hsa005000.56779256
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56615083
97Apoptosis_Homo sapiens_hsa042100.53668115
98Taste transduction_Homo sapiens_hsa047420.52175482
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51023579
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49126893
101RNA degradation_Homo sapiens_hsa030180.48718748
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48664804
103Carbon metabolism_Homo sapiens_hsa012000.47200085
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46302239
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46013929
106AMPK signaling pathway_Homo sapiens_hsa041520.45760678
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44995411
108Linoleic acid metabolism_Homo sapiens_hsa005910.44756058
109MicroRNAs in cancer_Homo sapiens_hsa052060.44290104
110Complement and coagulation cascades_Homo sapiens_hsa046100.44021197
111ABC transporters_Homo sapiens_hsa020100.43434847
112Dorso-ventral axis formation_Homo sapiens_hsa043200.43263998
113Histidine metabolism_Homo sapiens_hsa003400.42518504
114Chemical carcinogenesis_Homo sapiens_hsa052040.42411637
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41252873
116Alcoholism_Homo sapiens_hsa050340.41191089
117Small cell lung cancer_Homo sapiens_hsa052220.40954059
118Basal transcription factors_Homo sapiens_hsa030220.39860305
119Insulin signaling pathway_Homo sapiens_hsa049100.39346863
120Colorectal cancer_Homo sapiens_hsa052100.38764603
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38696764
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37967127
123Fat digestion and absorption_Homo sapiens_hsa049750.37658708
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.37456156
125B cell receptor signaling pathway_Homo sapiens_hsa046620.37102835
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36917004
127Inositol phosphate metabolism_Homo sapiens_hsa005620.36531356
128Primary immunodeficiency_Homo sapiens_hsa053400.35875130
129PPAR signaling pathway_Homo sapiens_hsa033200.35671651
130Butanoate metabolism_Homo sapiens_hsa006500.35234618
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34031602
132beta-Alanine metabolism_Homo sapiens_hsa004100.33895853
133Phenylalanine metabolism_Homo sapiens_hsa003600.32589523
134Steroid biosynthesis_Homo sapiens_hsa001000.29172265
135Vitamin B6 metabolism_Homo sapiens_hsa007500.28742584
136Tyrosine metabolism_Homo sapiens_hsa003500.28275721
137Asthma_Homo sapiens_hsa053100.28011284
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27687190
139Cardiac muscle contraction_Homo sapiens_hsa042600.27569751
140Metabolic pathways_Homo sapiens_hsa011000.26389384
141Viral myocarditis_Homo sapiens_hsa054160.26287330
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25123940
143HTLV-I infection_Homo sapiens_hsa051660.24594072
144Pancreatic cancer_Homo sapiens_hsa052120.22028899
145Hepatitis C_Homo sapiens_hsa051600.21594265
146Influenza A_Homo sapiens_hsa051640.20784064
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19842296
148Caffeine metabolism_Homo sapiens_hsa002320.19603629
149Prostate cancer_Homo sapiens_hsa052150.18394935
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.17978351
151Legionellosis_Homo sapiens_hsa051340.17496896
152Acute myeloid leukemia_Homo sapiens_hsa052210.15309692
153Hepatitis B_Homo sapiens_hsa051610.13770238
154Vibrio cholerae infection_Homo sapiens_hsa051100.12130999

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