BIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.54418046
2central nervous system myelination (GO:0022010)5.54418046
3positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.33306119
4striated muscle contraction (GO:0006941)5.25828078
5synaptic vesicle maturation (GO:0016188)5.18412462
6regulation of relaxation of muscle (GO:1901077)5.09667334
7actin filament-based movement (GO:0030048)5.07144525
8response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.66112068
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.54746354
10myofibril assembly (GO:0030239)4.50024857
11response to muscle activity (GO:0014850)4.44529364
12neuronal action potential propagation (GO:0019227)4.23108265
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.17579522
14cardiac muscle contraction (GO:0060048)4.09448655
15positive regulation of myotube differentiation (GO:0010831)4.07930475
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.99272459
17locomotory exploration behavior (GO:0035641)3.97184016
18sarcomere organization (GO:0045214)3.92386929
19muscle contraction (GO:0006936)3.90374059
20synaptic vesicle exocytosis (GO:0016079)3.88856361
21sarcoplasmic reticulum calcium ion transport (GO:0070296)3.87658217
22ensheathment of neurons (GO:0007272)3.83615781
23axon ensheathment (GO:0008366)3.83615781
24myelination (GO:0042552)3.83163110
25skeletal muscle contraction (GO:0003009)3.76502433
26positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.73475080
27actin-myosin filament sliding (GO:0033275)3.64577276
28muscle filament sliding (GO:0030049)3.64577276
29regulation of synaptic vesicle exocytosis (GO:2000300)3.60713873
30muscle system process (GO:0003012)3.53350832
31glutamate secretion (GO:0014047)3.49041258
32regulation of actin filament-based movement (GO:1903115)3.47399250
33creatine metabolic process (GO:0006600)3.45931933
34cellular potassium ion homeostasis (GO:0030007)3.41347023
35cardiac myofibril assembly (GO:0055003)3.40844425
36regulation of synapse structural plasticity (GO:0051823)3.38885232
37skeletal muscle tissue development (GO:0007519)3.38605229
38L-amino acid import (GO:0043092)3.38449237
39glycogen catabolic process (GO:0005980)3.37740204
40regulation of skeletal muscle cell differentiation (GO:2001014)3.37632058
41positive regulation of synapse maturation (GO:0090129)3.35731656
42sodium ion export (GO:0071436)3.33206297
43muscle fiber development (GO:0048747)3.31686640
44layer formation in cerebral cortex (GO:0021819)3.29797766
45positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.29238790
46striated muscle adaptation (GO:0014888)3.27963981
47glycine transport (GO:0015816)3.27504357
48skeletal muscle adaptation (GO:0043501)3.27167554
49regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.25458659
50negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.22840827
51cardiac muscle hypertrophy (GO:0003300)3.21974317
52skeletal muscle fiber development (GO:0048741)3.18366628
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17484134
54neuromuscular synaptic transmission (GO:0007274)3.17197755
55regulation of synaptic vesicle transport (GO:1902803)3.16745044
56plasma membrane repair (GO:0001778)3.16514052
57glucan catabolic process (GO:0009251)3.16004603
58protein localization to synapse (GO:0035418)3.14448675
59actomyosin structure organization (GO:0031032)3.13491760
60regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.12142189
61vocalization behavior (GO:0071625)3.12054920
62membrane tubulation (GO:0097320)3.10758428
63nerve growth factor signaling pathway (GO:0038180)3.10355579
64dendrite morphogenesis (GO:0048813)3.07360948
65positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.06278286
66adult walking behavior (GO:0007628)3.06189408
67ionotropic glutamate receptor signaling pathway (GO:0035235)3.05825233
68regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.05122904
69striated muscle hypertrophy (GO:0014897)3.04317517
70potassium ion import (GO:0010107)3.03324640
71regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03115620
72NADH metabolic process (GO:0006734)3.02015518
73peptidyl-tyrosine autophosphorylation (GO:0038083)3.00943617
74regulation of ARF protein signal transduction (GO:0032012)3.00153863
75neuronal ion channel clustering (GO:0045161)2.99900570
76negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.99392050
77negative regulation of calcium ion transmembrane transport (GO:1903170)2.99392050
78regulation of neuronal synaptic plasticity (GO:0048168)2.97182797
79cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95834234
80cellular polysaccharide catabolic process (GO:0044247)2.94726556
81regulation of ARF GTPase activity (GO:0032312)2.93661923
82cytoskeletal anchoring at plasma membrane (GO:0007016)2.93009346
83negative regulation of inclusion body assembly (GO:0090084)2.93004644
84cerebellar granule cell differentiation (GO:0021707)2.90702663
85regulation of striated muscle contraction (GO:0006942)2.90145588
86muscle cell cellular homeostasis (GO:0046716)2.90086036
87regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.89889152
88muscle hypertrophy (GO:0014896)2.89180891
89dendritic spine morphogenesis (GO:0060997)2.88883146
90glycogen biosynthetic process (GO:0005978)2.87013658
91glucan biosynthetic process (GO:0009250)2.87013658
92actin-mediated cell contraction (GO:0070252)2.86994711
93neuromuscular process controlling balance (GO:0050885)2.86155451
94regulation of cell communication by electrical coupling (GO:0010649)2.85999613
95myelin maintenance (GO:0043217)2.85855971
96muscle cell fate commitment (GO:0042693)2.84060303
97skeletal muscle tissue regeneration (GO:0043403)2.83966208
98transmission of nerve impulse (GO:0019226)2.83753347
99exploration behavior (GO:0035640)2.82850872
100cardiac muscle hypertrophy in response to stress (GO:0014898)2.82168518
101muscle hypertrophy in response to stress (GO:0003299)2.82168518
102cardiac muscle adaptation (GO:0014887)2.82168518
103neuron cell-cell adhesion (GO:0007158)2.82047137
104regulation of glutamate receptor signaling pathway (GO:1900449)2.81984042
105regulation of synapse maturation (GO:0090128)2.81955875
106myotube differentiation (GO:0014902)2.81932429
107synaptic vesicle docking involved in exocytosis (GO:0016081)2.81341960
108regulation of skeletal muscle contraction (GO:0014819)2.79818977
109establishment of mitochondrion localization (GO:0051654)2.79294956
110negative regulation of axonogenesis (GO:0050771)2.79242264
111neurotransmitter secretion (GO:0007269)2.77109842
112negative regulation of potassium ion transmembrane transport (GO:1901380)2.76635315
113muscle organ development (GO:0007517)2.76570973
114presynaptic membrane organization (GO:0097090)2.76547671
115myoblast fusion (GO:0007520)2.76539240
116positive regulation of myoblast differentiation (GO:0045663)2.74983637
117protein localization to endosome (GO:0036010)2.74224308
118neuromuscular junction development (GO:0007528)2.74212350
119regulation of dendritic spine morphogenesis (GO:0061001)2.73305762
120regulation of membrane repolarization (GO:0060306)2.72300112
121striated muscle atrophy (GO:0014891)2.71794720
122muscle structure development (GO:0061061)2.71786423
123regulation of long-term neuronal synaptic plasticity (GO:0048169)2.70875234
124muscle adaptation (GO:0043500)2.70403406
125synaptic vesicle endocytosis (GO:0048488)2.70072875
126positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68092504
127long-term memory (GO:0007616)2.67992856
128membrane depolarization during action potential (GO:0086010)2.67710069
129negative regulation of muscle contraction (GO:0045932)2.67357378
130regulation of excitatory postsynaptic membrane potential (GO:0060079)2.65912260
131activation of protein kinase A activity (GO:0034199)2.65722357
132regulation of calcium ion transmembrane transport (GO:1903169)2.64859210
133regulation of calcium ion transmembrane transporter activity (GO:1901019)2.64859210
134neuron recognition (GO:0008038)2.64813015
135long-chain fatty acid biosynthetic process (GO:0042759)2.63837444
136myotube cell development (GO:0014904)2.63602566
137regulation of female receptivity (GO:0045924)2.62981529
138regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.62748894
139polysaccharide catabolic process (GO:0000272)2.62615532
140synaptic transmission, glutamatergic (GO:0035249)2.61837400
141glutamate receptor signaling pathway (GO:0007215)2.60045238
142positive regulation of membrane potential (GO:0045838)2.58913556
143response to inactivity (GO:0014854)2.57727300
144regulation of dendritic spine development (GO:0060998)2.57699745
145amino acid import (GO:0043090)2.57629408
146negative regulation of protein localization to cell surface (GO:2000009)2.56501330
147neuromuscular process controlling posture (GO:0050884)2.56443000
148cerebellar Purkinje cell differentiation (GO:0021702)2.55848044
149gamma-aminobutyric acid signaling pathway (GO:0007214)2.54846001
150vesicle transport along microtubule (GO:0047496)2.53581043
151cortical actin cytoskeleton organization (GO:0030866)2.53531197
152potassium ion homeostasis (GO:0055075)2.53150046
153oligodendrocyte differentiation (GO:0048709)2.52505028
154negative regulation of neurotransmitter secretion (GO:0046929)2.51646251
155regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.51502862
156neuron-neuron synaptic transmission (GO:0007270)2.50929176
157gamma-aminobutyric acid transport (GO:0015812)2.50513996
158substantia nigra development (GO:0021762)2.48342908
159organelle transport along microtubule (GO:0072384)2.47890304
160regulation of Rap GTPase activity (GO:0032317)2.45740207
161negative regulation of neurotransmitter transport (GO:0051589)2.45518819
162regulation of postsynaptic membrane potential (GO:0060078)2.45498618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.32171771
2EZH2_22144423_ChIP-Seq_EOC_Human3.63257884
3DROSHA_22980978_ChIP-Seq_HELA_Human2.75377384
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68595546
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60256003
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.52474117
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49676683
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49676683
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45884982
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43542622
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35831283
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.29623160
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.29177296
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27894399
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22967061
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15705013
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13213190
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09231672
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08685668
20GBX2_23144817_ChIP-Seq_PC3_Human2.08464637
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.04340721
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.98362243
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97863230
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88939040
25REST_21632747_ChIP-Seq_MESCs_Mouse1.86113288
26AR_21572438_ChIP-Seq_LNCaP_Human1.79239391
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74886017
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.73500222
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.72540351
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.67316070
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65886424
32* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61128655
33KDM2B_26808549_Chip-Seq_K562_Human1.60035044
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.58257339
35* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56115123
36* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52589714
37TCF7_22412390_ChIP-Seq_EML_Mouse1.49614285
38* TBX20_22080862_ChIP-Seq_HEART_Mouse1.47606003
39* TBX20_22328084_ChIP-Seq_HEART_Mouse1.47606003
40KDM2B_26808549_Chip-Seq_DND41_Human1.45783317
41* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44517697
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44481199
43* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32773487
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31966731
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30885751
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30165763
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27471825
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27257330
49* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27231963
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27106781
51GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25831071
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.24457087
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.23540561
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.23276584
55LXR_22292898_ChIP-Seq_THP-1_Human1.21629353
56VDR_21846776_ChIP-Seq_THP-1_Human1.21283961
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20337710
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.19725319
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.19498878
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.18708922
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18470562
62* P68_20966046_ChIP-Seq_HELA_Human1.18294359
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18148735
64SA1_27219007_Chip-Seq_Bcells_Human1.16673543
65* ERG_21242973_ChIP-ChIP_JURKAT_Human1.15842594
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15535251
67* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13596546
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.13075896
69* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12616271
70* OCT4_19829295_ChIP-Seq_ESCs_Human1.11651230
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10992908
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10143808
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09027638
74* CTCF_27219007_Chip-Seq_Bcells_Human1.08659188
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08611682
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05401623
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04773791
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03866609
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.03805234
80* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03786997
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03104312
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.02787430
83OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02223142
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01286330
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00098379
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98581018
87SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98181051
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97794313
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97686941
90RACK7_27058665_Chip-Seq_MCF-7_Human0.97001635
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96840594
92SOX2_21211035_ChIP-Seq_LN229_Gbm0.96750397
93* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96491706
94* TET1_21490601_ChIP-Seq_MESCs_Mouse0.96433923
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96319607
96SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96001602
97* ELK3_25401928_ChIP-Seq_HUVEC_Human0.95227628
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94673020
99CREB1_26743006_Chip-Seq_LNCaP_Human0.94399264
100AR_19668381_ChIP-Seq_PC3_Human0.94211269
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94187568
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93591886
103EGR1_19032775_ChIP-ChIP_M12_Human0.92097740
104SPI1_23127762_ChIP-Seq_K562_Human0.91733394
105ELF1_20517297_ChIP-Seq_JURKAT_Human0.91362801
106CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91020276
107SMAD_19615063_ChIP-ChIP_OVARY_Human0.90700384
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90642774
109DPY_21335234_ChIP-Seq_ESCs_Mouse0.90268672
110* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90115236
111SPI1_20517297_ChIP-Seq_HL60_Human0.89330259
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89303459
113* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88863081
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86491460
115MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86429741
116STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86204563
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86096893
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86061238
119AHR_22903824_ChIP-Seq_MCF-7_Human0.85905989
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.84790164
121KLF4_19829295_ChIP-Seq_ESCs_Human0.84394550
122ZNF274_21170338_ChIP-Seq_K562_Hela0.84167662
123SMC4_20622854_ChIP-Seq_HELA_Human0.84140146
124RUNX_20019798_ChIP-Seq_JUKART_Human0.83954867
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83364002
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83018299
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81863679
128CTBP1_25329375_ChIP-Seq_LNCAP_Human0.80941108
129SMAD4_21799915_ChIP-Seq_A2780_Human0.80004525
130ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79820990
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79707537
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.79449807
133TP53_16413492_ChIP-PET_HCT116_Human0.79195072
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78514347
135EP300_21415370_ChIP-Seq_HL-1_Mouse0.78065036
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77457153
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.77284749
138SMAD3_21741376_ChIP-Seq_EPCs_Human0.75887218
139TP53_23651856_ChIP-Seq_MEFs_Mouse0.75862512
140* SMAD4_21741376_ChIP-Seq_ESCs_Human0.75763772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.18345540
2MP0004270_analgesia4.34585961
3MP0004145_abnormal_muscle_electrophysio3.92395809
4MP0003880_abnormal_central_pattern3.67696816
5MP0000751_myopathy3.16666672
6MP0003635_abnormal_synaptic_transmissio3.09087870
7MP0000920_abnormal_myelination2.98814057
8MP0000749_muscle_degeneration2.96697344
9MP0000747_muscle_weakness2.96172778
10MP0002064_seizures2.63305497
11MP0005451_abnormal_body_composition2.38803999
12MP0009745_abnormal_behavioral_response2.37850313
13MP0002332_abnormal_exercise_endurance2.37078204
14MP0005423_abnormal_somatic_nervous2.34558003
15MP0002272_abnormal_nervous_system2.25302938
16MP0002734_abnormal_mechanical_nocicepti2.20624252
17MP0009046_muscle_twitch2.17513976
18MP0002063_abnormal_learning/memory/cond2.15968947
19MP0003329_amyloid_beta_deposits2.15583281
20MP0001486_abnormal_startle_reflex2.12012088
21MP0008569_lethality_at_weaning2.10857053
22MP0003690_abnormal_glial_cell1.95122811
23MP0000759_abnormal_skeletal_muscle1.85018240
24MP0000733_abnormal_muscle_development1.81233086
25MP0004084_abnormal_cardiac_muscle1.75528589
26MP0002106_abnormal_muscle_physiology1.74921462
27MP0004885_abnormal_endolymph1.74725386
28MP0002572_abnormal_emotion/affect_behav1.74402735
29MP0000955_abnormal_spinal_cord1.68057163
30MP0003634_abnormal_glial_cell1.67593996
31MP0001440_abnormal_grooming_behavior1.66636070
32MP0001968_abnormal_touch/_nociception1.64076307
33MP0004142_abnormal_muscle_tone1.60386503
34MP0001299_abnormal_eye_distance/1.54388131
35MP0000778_abnormal_nervous_system1.53054874
36MP0005369_muscle_phenotype1.52682363
37MP0002067_abnormal_sensory_capabilities1.51559596
38* MP0004087_abnormal_muscle_fiber1.50452933
39MP0003950_abnormal_plasma_membrane1.49910153
40MP0002269_muscular_atrophy1.46473391
41MP0004233_abnormal_muscle_weight1.46472320
42MP0004811_abnormal_neuron_physiology1.45224015
43MP0001970_abnormal_pain_threshold1.44999168
44MP0004036_abnormal_muscle_relaxation1.44681804
45MP0002882_abnormal_neuron_morphology1.42639389
46* MP0005330_cardiomyopathy1.39015859
47MP0002066_abnormal_motor_capabilities/c1.38805437
48MP0002972_abnormal_cardiac_muscle1.38510585
49MP0009780_abnormal_chondrocyte_physiolo1.37764746
50MP0002229_neurodegeneration1.36742475
51MP0003633_abnormal_nervous_system1.36442353
52MP0005623_abnormal_meninges_morphology1.35499497
53MP0002184_abnormal_innervation1.35151155
54MP0002733_abnormal_thermal_nociception1.32092405
55MP0002822_catalepsy1.31125445
56MP0000013_abnormal_adipose_tissue1.26678524
57MP0000750_abnormal_muscle_regeneration1.24640790
58MP0001905_abnormal_dopamine_level1.23432909
59MP0001501_abnormal_sleep_pattern1.21910268
60MP0004858_abnormal_nervous_system1.18899951
61MP0003075_altered_response_to1.18847901
62MP0006036_abnormal_mitochondrial_physio1.18447236
63MP0003631_nervous_system_phenotype1.17656849
64MP0002736_abnormal_nociception_after1.16968307
65MP0005620_abnormal_muscle_contractility1.16168871
66MP0004742_abnormal_vestibular_system1.16147719
67MP0005551_abnormal_eye_electrophysiolog1.15780684
68MP0002971_abnormal_brown_adipose1.12910136
69MP0000604_amyloidosis1.12797683
70MP0005386_behavior/neurological_phenoty1.12574794
71MP0004924_abnormal_behavior1.12574794
72MP0004130_abnormal_muscle_cell1.11763342
73MP0002090_abnormal_vision1.10501622
74MP0001502_abnormal_circadian_rhythm1.07244321
75MP0003172_abnormal_lysosome_physiology1.06314685
76MP0005058_abnormal_lysosome_morphology1.06245502
77MP0002909_abnormal_adrenal_gland1.03634313
78MP0002108_abnormal_muscle_morphology1.03268670
79MP0003632_abnormal_nervous_system1.01432650
80MP0002735_abnormal_chemical_nociception1.01381947
81MP0002557_abnormal_social/conspecific_i1.00976321
82MP0001529_abnormal_vocalization0.98742203
83MP0004215_abnormal_myocardial_fiber0.98009545
84MP0005166_decreased_susceptibility_to0.96802147
85MP0005167_abnormal_blood-brain_barrier0.96472656
86MP0004510_myositis0.95136808
87MP0005666_abnormal_adipose_tissue0.93255120
88* MP0010630_abnormal_cardiac_muscle0.92001934
89MP0002752_abnormal_somatic_nervous0.87940438
90MP0004134_abnormal_chest_morphology0.87678427
91MP0002152_abnormal_brain_morphology0.87154206
92MP0008874_decreased_physiological_sensi0.86298184
93MP0000003_abnormal_adipose_tissue0.85821564
94MP0001348_abnormal_lacrimal_gland0.84056035
95MP0003303_peritoneal_inflammation0.82607831
96MP0005535_abnormal_body_temperature0.81989507
97MP0006138_congestive_heart_failure0.80338871
98MP0003045_fibrosis0.80264141
99MP0005266_abnormal_metabolism0.78486459
100MP0006276_abnormal_autonomic_nervous0.78069389
101MP0005670_abnormal_white_adipose0.76960726
102MP0001544_abnormal_cardiovascular_syste0.76854509
103MP0005385_cardiovascular_system_phenoty0.76854509
104MP0003646_muscle_fatigue0.76360829
105MP0003879_abnormal_hair_cell0.75925453
106MP0005645_abnormal_hypothalamus_physiol0.75421406
107MP0008961_abnormal_basal_metabolism0.74940436
108MP0002127_abnormal_cardiovascular_syste0.74862617
109MP0002837_dystrophic_cardiac_calcinosis0.74130031
110MP0003137_abnormal_impulse_conducting0.73568111
111MP0005171_absent_coat_pigmentation0.68750564
112MP0001943_abnormal_respiration0.67319359
113MP0001346_abnormal_lacrimal_gland0.65999667
114MP0003828_pulmonary_edema0.65559711
115MP0003091_abnormal_cell_migration0.64943498
116MP0008438_abnormal_cutaneous_collagen0.64389129
117MP0003705_abnormal_hypodermis_morpholog0.60747097
118MP0001963_abnormal_hearing_physiology0.59749932
119MP0001986_abnormal_taste_sensitivity0.59657300
120* MP0002069_abnormal_eating/drinking_beha0.59319585
121MP0004484_altered_response_of0.59037288
122MP0001177_atelectasis0.58397511
123MP0008260_abnormal_autophagy0.58211370
124MP0004185_abnormal_adipocyte_glucose0.58186231
125MP0001485_abnormal_pinna_reflex0.56767487
126MP0005375_adipose_tissue_phenotype0.56576628
127MP0003191_abnormal_cellular_cholesterol0.56365392
128MP0009840_abnormal_foam_cell0.53568735

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.36958539
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.34812076
3Nemaline bodies (HP:0003798)6.21049316
4Type 1 muscle fiber predominance (HP:0003803)4.98998015
5Distal arthrogryposis (HP:0005684)4.95331027
6Round ear (HP:0100830)4.81437172
7Fetal akinesia sequence (HP:0001989)4.70778216
8Exercise-induced myalgia (HP:0003738)4.25515609
9Myopathic facies (HP:0002058)4.07333836
10Myokymia (HP:0002411)3.97926269
11Akinesia (HP:0002304)3.91418458
12Rhabdomyolysis (HP:0003201)3.90479010
13Difficulty running (HP:0009046)3.86868942
14Myoglobinuria (HP:0002913)3.68329924
15Calcaneovalgus deformity (HP:0001848)3.61494026
16Supranuclear gaze palsy (HP:0000605)3.60955807
17Ulnar deviation of the wrist (HP:0003049)3.59494482
18Muscle fiber splitting (HP:0003555)3.48425520
19Distal lower limb muscle weakness (HP:0009053)3.44080748
20Increased connective tissue (HP:0009025)3.40921055
21Muscle hypertrophy of the lower extremities (HP:0008968)3.37444249
22Hyporeflexia of lower limbs (HP:0002600)3.35630192
23* Centrally nucleated skeletal muscle fibers (HP:0003687)3.35468743
24Deformed tarsal bones (HP:0008119)3.34750910
25Ankle clonus (HP:0011448)3.30294687
26Subaortic stenosis (HP:0001682)3.28071172
27Abnormality of the left ventricular outflow tract (HP:0011103)3.28071172
28Neurofibrillary tangles (HP:0002185)3.27831772
29Exercise-induced muscle cramps (HP:0003710)3.25834234
30Abnormality of skeletal muscle fiber size (HP:0012084)3.20805101
31Focal motor seizures (HP:0011153)3.11561389
32Malignant hyperthermia (HP:0002047)3.11181079
33Increased variability in muscle fiber diameter (HP:0003557)3.02303737
34Rimmed vacuoles (HP:0003805)3.00628680
35Sudden death (HP:0001699)3.00252123
36Asymmetric septal hypertrophy (HP:0001670)2.99675543
37Calf muscle hypertrophy (HP:0008981)2.94842754
38Bundle branch block (HP:0011710)2.80827638
39Absent phalangeal crease (HP:0006109)2.79263478
40* EMG: myopathic abnormalities (HP:0003458)2.77028195
41Areflexia of lower limbs (HP:0002522)2.73051601
42Cerebral inclusion bodies (HP:0100314)2.71935917
43Spastic gait (HP:0002064)2.67751301
44Dysmetria (HP:0001310)2.60657237
45Focal seizures (HP:0007359)2.59670485
46Abnormality of the calf musculature (HP:0001430)2.58027117
47Frequent falls (HP:0002359)2.54913113
48Generalized muscle weakness (HP:0003324)2.52697959
49Mutism (HP:0002300)2.52472176
50Visual hallucinations (HP:0002367)2.51142035
51Action tremor (HP:0002345)2.47896290
52* Gowers sign (HP:0003391)2.46391444
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.45887096
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.45887096
55Onion bulb formation (HP:0003383)2.44023483
56Myotonia (HP:0002486)2.43623590
57Neck muscle weakness (HP:0000467)2.39530335
58Muscle stiffness (HP:0003552)2.37773014
59Urinary urgency (HP:0000012)2.37135945
60Lower limb amyotrophy (HP:0007210)2.36697694
61Popliteal pterygium (HP:0009756)2.35238433
62Peripheral hypomyelination (HP:0007182)2.35177022
63Intention tremor (HP:0002080)2.33730250
64Atonic seizures (HP:0010819)2.30181299
65Fatigable weakness (HP:0003473)2.29887502
66Abnormality of the neuromuscular junction (HP:0003398)2.29887502
67Difficulty climbing stairs (HP:0003551)2.29730120
68Abnormal finger flexion creases (HP:0006143)2.29004100
69Weak cry (HP:0001612)2.27918120
70Postural instability (HP:0002172)2.26582681
71Abnormality of the corticospinal tract (HP:0002492)2.26470173
72Slender build (HP:0001533)2.19279516
73Rapidly progressive (HP:0003678)2.17648949
74Lower limb muscle weakness (HP:0007340)2.16382480
75Distal lower limb amyotrophy (HP:0008944)2.11725155
76Achilles tendon contracture (HP:0001771)2.09109269
77Epileptic encephalopathy (HP:0200134)2.08635321
78Bulbar palsy (HP:0001283)2.07418305
79Aplasia of the musculature (HP:0100854)2.06605570
80Foot dorsiflexor weakness (HP:0009027)2.06564989
81Cerebral hypomyelination (HP:0006808)2.06468814
82Heart block (HP:0012722)2.03578416
83Hip contracture (HP:0003273)2.02999642
84Depression (HP:0000716)2.02468594
85Type 2 muscle fiber atrophy (HP:0003554)2.01767830
86Abnormal auditory evoked potentials (HP:0006958)2.01187048
87Urinary bladder sphincter dysfunction (HP:0002839)2.00441436
88Abnormality of the calcaneus (HP:0008364)1.98592057
89Abnormal atrioventricular conduction (HP:0005150)1.96167169
90Abnormality of placental membranes (HP:0011409)1.95236790
91Amniotic constriction ring (HP:0009775)1.95236790
92Muscle fiber atrophy (HP:0100295)1.95035942
93Rigidity (HP:0002063)1.93626314
94Spinal rigidity (HP:0003306)1.93124446
95Limb-girdle muscle atrophy (HP:0003797)1.92188387
96Neuronal loss in central nervous system (HP:0002529)1.91759566
97Mildly elevated creatine phosphokinase (HP:0008180)1.91728523
98Termporal pattern (HP:0011008)1.91176674
99Insidious onset (HP:0003587)1.91176674
100Metatarsus adductus (HP:0001840)1.89099203
101Easy fatigability (HP:0003388)1.88929927
102* Scapular winging (HP:0003691)1.88714564
103Obstructive sleep apnea (HP:0002870)1.88714216
104Abnormality of the foot musculature (HP:0001436)1.87648953
105Diplopia (HP:0000651)1.85845689
106Abnormality of binocular vision (HP:0011514)1.85845689
107Broad-based gait (HP:0002136)1.84713641
108Absence seizures (HP:0002121)1.79990169
109Impaired vibration sensation in the lower limbs (HP:0002166)1.79838270
110Scanning speech (HP:0002168)1.79532021
111Upper limb amyotrophy (HP:0009129)1.78800650
112Distal upper limb amyotrophy (HP:0007149)1.78800650
113Generalized tonic-clonic seizures (HP:0002069)1.78629250
114* Waddling gait (HP:0002515)1.78261043
115Dilated cardiomyopathy (HP:0001644)1.77705435
116EMG: neuropathic changes (HP:0003445)1.77662237
117Megalencephaly (HP:0001355)1.77051940
118Abnormality of the Achilles tendon (HP:0005109)1.74993685
119Ulnar deviation of finger (HP:0009465)1.74882795
120Nonprogressive disorder (HP:0003680)1.74391037
121Arterial tortuosity (HP:0005116)1.73424742
122Dialeptic seizures (HP:0011146)1.72821362
123Dysdiadochokinesis (HP:0002075)1.72732565
124Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72059548
125Ventricular tachycardia (HP:0004756)1.71573305
126Insomnia (HP:0100785)1.71495215
127Progressive cerebellar ataxia (HP:0002073)1.71019744
128Abnormality of the musculature of the pelvis (HP:0001469)1.70974430
129Febrile seizures (HP:0002373)1.66830287
130Hyperkalemia (HP:0002153)1.65756402
131Stridor (HP:0010307)1.65140153
132Muscular dystrophy (HP:0003560)1.64244871
133Thin ribs (HP:0000883)1.63276291
134Lipoatrophy (HP:0100578)1.60638247
135* Respiratory insufficiency due to muscle weakness (HP:0002747)1.59713215
136Progressive muscle weakness (HP:0003323)1.55287760
137Hemiplegia (HP:0002301)1.54810676

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K92.71157859
2PAK62.59830963
3PHKG12.35664629
4PHKG22.35664629
5OBSCN2.34293066
6EPHA42.23201637
7STK392.14310560
8NTRK32.13301321
9PRPF4B2.04028157
10LIMK11.96855306
11CDK191.96207599
12KSR21.90149209
13OXSR11.89610903
14MARK11.80319164
15NTRK11.77063524
16PKN11.75221938
17TTN1.65446276
18PRKD31.62032753
19ICK1.60491666
20EPHB11.59596249
21MINK11.55295674
22PIK3CG1.53512787
23TYRO31.50155323
24UHMK11.48213210
25MAP2K31.47481776
26CAMKK11.44409183
27MOS1.39231717
28ROCK21.36243394
29CDK51.35048569
30MAP3K131.34283421
31WNK11.31927409
32MAP3K111.30714453
33FES1.29985559
34CDK141.27037989
35CDK151.26325733
36MAP3K41.25171465
37TRIB31.23736329
38MAP3K71.23025373
39DMPK1.20840299
40CDK181.20516762
41PRKCH1.18739081
42CDK11A1.13361342
43NTRK21.11710253
44MUSK1.10994093
45MARK21.09205970
46SIK21.09082202
47CAMK1G1.05293178
48NME11.04449515
49ARAF1.03885620
50DAPK21.03525521
51CAMK2B1.01678445
52MAPK121.01140440
53CSNK1G21.00167392
54PINK10.95162938
55RIPK40.94090125
56PDPK10.92447931
57CLK10.91192755
58CAMK2G0.90550270
59SGK4940.89316121
60SGK2230.89316121
61STK110.89285147
62NEK60.89096899
63CSNK1A1L0.88592332
64CSNK1G30.88105492
65FGFR20.87457911
66MAPKAPK50.87224422
67ALK0.86751111
68MAP2K40.86345220
69KSR10.84954597
70TESK10.83017960
71PDK10.82256150
72FGR0.81236844
73LATS20.79062244
74CAMK2D0.78850180
75DYRK1B0.77540808
76PRKD10.76097332
77PNCK0.75865680
78MAPK70.75242856
79MAP4K10.74239320
80SCYL20.73296599
81DDR20.73017767
82PAK30.71783626
83CAMK40.71633865
84TAOK20.70950840
85CCNB10.70784383
86RET0.70710762
87FYN0.70707289
88SGK30.69523843
89TNIK0.69345566
90CAMK2A0.69263287
91DAPK30.66642986
92MAP2K60.65963624
93MAPK40.64561463
94TESK20.64558485
95EEF2K0.64253234
96CAMKK20.64063286
97MAPK130.63927869
98BMX0.61567221
99ZAP700.61528188
100KDR0.59983028
101MAPKAPK30.59358463
102ILK0.58439214
103BCR0.57733388
104PTK2B0.55988072
105RIPK10.54646377
106SGK20.54242104
107CAMK10.53178562
108TBK10.52795721
109CSF1R0.52439599
110TNK20.52070237
111TAOK10.50953362
112ROCK10.50666332
113MAP3K20.48099278
114SGK10.47738929
115MAPK110.47091850
116GRK50.46672126
117CSNK1G10.46535094
118MAPK100.46025674
119STK380.45854821
120ERN10.44721592
121RPS6KA30.44636941
122PRKG10.43577201
123MAP2K10.43536177
124HCK0.43414543
125MAP3K10.43132995
126PRKAA10.41781188
127AKT20.41695502
128SYK0.39827421
129CDC42BPA0.38192375
130JAK10.38111327
131PRKAA20.35586212
132JAK20.35585360
133BRAF0.34340065
134TRPM70.33114808

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.37800684
2GABAergic synapse_Homo sapiens_hsa047272.16563721
3Olfactory transduction_Homo sapiens_hsa047402.10693186
4Circadian entrainment_Homo sapiens_hsa047132.02727286
5Nicotine addiction_Homo sapiens_hsa050331.91864211
6Glutamatergic synapse_Homo sapiens_hsa047241.90932562
7Morphine addiction_Homo sapiens_hsa050321.90003813
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.89188944
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87612128
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87199618
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.83574854
12Nitrogen metabolism_Homo sapiens_hsa009101.80132191
13Oxytocin signaling pathway_Homo sapiens_hsa049211.77915540
14Salivary secretion_Homo sapiens_hsa049701.71591436
15Long-term potentiation_Homo sapiens_hsa047201.70360065
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70013446
17Gastric acid secretion_Homo sapiens_hsa049711.69904847
18Cholinergic synapse_Homo sapiens_hsa047251.63769364
19Dopaminergic synapse_Homo sapiens_hsa047281.56700458
20Glucagon signaling pathway_Homo sapiens_hsa049221.54792267
21Dilated cardiomyopathy_Homo sapiens_hsa054141.54585481
22Axon guidance_Homo sapiens_hsa043601.51309651
23Long-term depression_Homo sapiens_hsa047301.44629806
24Amphetamine addiction_Homo sapiens_hsa050311.43544052
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42726433
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42613919
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38013187
28Insulin secretion_Homo sapiens_hsa049111.36927104
29Circadian rhythm_Homo sapiens_hsa047101.35415455
30GnRH signaling pathway_Homo sapiens_hsa049121.34297739
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33884514
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.31088299
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.30596034
34Cocaine addiction_Homo sapiens_hsa050301.29962121
35Renin secretion_Homo sapiens_hsa049241.29091090
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28648063
37Calcium signaling pathway_Homo sapiens_hsa040201.26046671
38Serotonergic synapse_Homo sapiens_hsa047261.22603531
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22057607
40Gap junction_Homo sapiens_hsa045401.21330396
41Renal cell carcinoma_Homo sapiens_hsa052111.19639877
42* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17301206
43Cardiac muscle contraction_Homo sapiens_hsa042601.17241334
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.17044545
45Arginine and proline metabolism_Homo sapiens_hsa003301.16334950
46* Endocytosis_Homo sapiens_hsa041441.15593787
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13181640
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12300178
49ErbB signaling pathway_Homo sapiens_hsa040121.12259814
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.08998109
51Glioma_Homo sapiens_hsa052141.07949428
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06740034
53cAMP signaling pathway_Homo sapiens_hsa040241.06058331
54MAPK signaling pathway_Homo sapiens_hsa040101.03924417
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02942140
56Phototransduction_Homo sapiens_hsa047441.02751171
57Pentose phosphate pathway_Homo sapiens_hsa000301.00863100
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00381843
59B cell receptor signaling pathway_Homo sapiens_hsa046620.99922459
60Estrogen signaling pathway_Homo sapiens_hsa049150.97065623
61VEGF signaling pathway_Homo sapiens_hsa043700.96205554
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.93286520
63Type II diabetes mellitus_Homo sapiens_hsa049300.91125345
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.88892899
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.88609735
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86650343
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85367375
68AMPK signaling pathway_Homo sapiens_hsa041520.85313281
69Arginine biosynthesis_Homo sapiens_hsa002200.84890721
70Dorso-ventral axis formation_Homo sapiens_hsa043200.84434120
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82822088
72Chemokine signaling pathway_Homo sapiens_hsa040620.82754391
73Carbon metabolism_Homo sapiens_hsa012000.82603486
74Tight junction_Homo sapiens_hsa045300.81854169
75Viral myocarditis_Homo sapiens_hsa054160.80505506
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80094121
77Pancreatic secretion_Homo sapiens_hsa049720.80061171
78Ras signaling pathway_Homo sapiens_hsa040140.79824207
79Lysosome_Homo sapiens_hsa041420.79340689
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78332662
81Choline metabolism in cancer_Homo sapiens_hsa052310.77982675
82Insulin resistance_Homo sapiens_hsa049310.76422708
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73803970
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73302790
85Taste transduction_Homo sapiens_hsa047420.72656066
86Prion diseases_Homo sapiens_hsa050200.71790864
87Salmonella infection_Homo sapiens_hsa051320.71536326
88Melanogenesis_Homo sapiens_hsa049160.71161827
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69874890
90Platelet activation_Homo sapiens_hsa046110.69567615
91Vibrio cholerae infection_Homo sapiens_hsa051100.69330278
92Rap1 signaling pathway_Homo sapiens_hsa040150.67418834
93Focal adhesion_Homo sapiens_hsa045100.66531941
94Fructose and mannose metabolism_Homo sapiens_hsa000510.65617635
95Collecting duct acid secretion_Homo sapiens_hsa049660.64463652
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62201081
97T cell receptor signaling pathway_Homo sapiens_hsa046600.62071183
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61001633
99Ether lipid metabolism_Homo sapiens_hsa005650.60346705
100Inositol phosphate metabolism_Homo sapiens_hsa005620.59478473
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58048670
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56685033
103Non-small cell lung cancer_Homo sapiens_hsa052230.56367315
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55053432
105Proteoglycans in cancer_Homo sapiens_hsa052050.54940890
106Alzheimers disease_Homo sapiens_hsa050100.54477513
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53975283
108Osteoclast differentiation_Homo sapiens_hsa043800.53915786
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53771995
110Insulin signaling pathway_Homo sapiens_hsa049100.53287531
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.52460501
112mTOR signaling pathway_Homo sapiens_hsa041500.52403558
113Bile secretion_Homo sapiens_hsa049760.52267241
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51777947
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51415545
116Chronic myeloid leukemia_Homo sapiens_hsa052200.47675611
117Shigellosis_Homo sapiens_hsa051310.47142800
118Histidine metabolism_Homo sapiens_hsa003400.46728119
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45065151
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44387921
121Thyroid hormone synthesis_Homo sapiens_hsa049180.42795507
122Tuberculosis_Homo sapiens_hsa051520.42408635
123Amoebiasis_Homo sapiens_hsa051460.40977960
124Phagosome_Homo sapiens_hsa041450.40618083
125Biosynthesis of amino acids_Homo sapiens_hsa012300.39075951
126HIF-1 signaling pathway_Homo sapiens_hsa040660.37677570

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