BIN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.93263238
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.79754605
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.49869976
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.49869976
5neutrophil activation involved in immune response (GO:0002283)5.25355884
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.90629524
7antigen processing and presentation of endogenous antigen (GO:0019883)4.75055384
8ribosomal small subunit assembly (GO:0000028)4.71004086
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.64958781
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.64958781
11modulation by symbiont of host immune response (GO:0052553)4.64958781
12positive regulation by symbiont of host defense response (GO:0052509)4.64958781
13modulation by symbiont of host defense response (GO:0052031)4.64958781
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.64958781
15macrophage activation involved in immune response (GO:0002281)4.46767484
16regulation of gamma-delta T cell differentiation (GO:0045586)4.46610454
17antigen processing and presentation via MHC class Ib (GO:0002475)4.34748716
18microglial cell activation (GO:0001774)4.28833632
19DNA deamination (GO:0045006)4.24248152
20cellular extravasation (GO:0045123)4.23984483
21regulation of B cell receptor signaling pathway (GO:0050855)4.23932778
22regulation of gamma-delta T cell activation (GO:0046643)4.17666428
23detection of other organism (GO:0098543)4.15478739
24neutrophil activation (GO:0042119)4.14099200
25negative regulation of lymphocyte mediated immunity (GO:0002707)4.10048038
26negative regulation of interleukin-12 production (GO:0032695)4.03928550
27positive regulation of B cell differentiation (GO:0045579)4.01574914
28detection of bacterium (GO:0016045)4.01503985
29negative regulation of T cell mediated immunity (GO:0002710)3.99843470
30activated T cell proliferation (GO:0050798)3.86073888
31myeloid cell activation involved in immune response (GO:0002275)3.83293548
32regulation of B cell differentiation (GO:0045577)3.82508337
33immunoglobulin mediated immune response (GO:0016064)3.77492103
34leukocyte aggregation (GO:0070486)3.76208192
35granulocyte activation (GO:0036230)3.73451902
36response to peptidoglycan (GO:0032494)3.69523300
37regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.68378905
38negative T cell selection (GO:0043383)3.67743735
39respiratory burst (GO:0045730)3.66885327
40negative thymic T cell selection (GO:0045060)3.65996321
41mast cell activation (GO:0045576)3.65457557
42interferon-gamma production (GO:0032609)3.64738883
43negative regulation of leukocyte mediated immunity (GO:0002704)3.63811922
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.63525878
45viral transcription (GO:0019083)3.61687560
46response to interleukin-15 (GO:0070672)3.61290256
47negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.55640242
48negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.53812614
49negative regulation of cell killing (GO:0031342)3.53812614
50positive thymic T cell selection (GO:0045059)3.52526989
51regulation of alpha-beta T cell proliferation (GO:0046640)3.49156452
52Arp2/3 complex-mediated actin nucleation (GO:0034314)3.47800946
53leukocyte degranulation (GO:0043299)3.47468921
54translational termination (GO:0006415)3.46904820
55definitive hemopoiesis (GO:0060216)3.46422971
56regulation of T cell tolerance induction (GO:0002664)3.46418156
57T cell homeostasis (GO:0043029)3.45880858
58positive regulation of mast cell activation (GO:0033005)3.44955363
59detection of external biotic stimulus (GO:0098581)3.43245765
60response to interferon-beta (GO:0035456)3.42758988
61cellular response to interleukin-15 (GO:0071350)3.42730163
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.40790215
63negative regulation of erythrocyte differentiation (GO:0045647)3.40527448
64regulation of mast cell degranulation (GO:0043304)3.36260856
65response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.36177105
66response to host immune response (GO:0052572)3.36177105
67regulation of tolerance induction (GO:0002643)3.35461376
68T cell migration (GO:0072678)3.35366622
69leukocyte migration involved in inflammatory response (GO:0002523)3.32458201
70B cell mediated immunity (GO:0019724)3.32438842
71macrophage activation (GO:0042116)3.32179756
72regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.28459736
73regulation of interferon-beta biosynthetic process (GO:0045357)3.28080723
74regulation of T cell receptor signaling pathway (GO:0050856)3.23674514
75B cell receptor signaling pathway (GO:0050853)3.22834904
76megakaryocyte development (GO:0035855)3.22271885
77response to type I interferon (GO:0034340)3.19760353
78defense response to protozoan (GO:0042832)3.18980311
79type I interferon signaling pathway (GO:0060337)3.18494529
80cellular response to type I interferon (GO:0071357)3.18494529
81positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.15608614
82detection of biotic stimulus (GO:0009595)3.14426334
83response to protozoan (GO:0001562)3.13691881
84positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.13546179
85mature B cell differentiation involved in immune response (GO:0002313)3.13510785
86detection of molecule of bacterial origin (GO:0032490)3.12161509
87neutrophil mediated immunity (GO:0002446)3.11714807
88regulation of mast cell activation (GO:0033003)3.11342172
89regulation of mast cell activation involved in immune response (GO:0033006)3.11047327
90positive regulation of tolerance induction (GO:0002645)3.07987744
91production of molecular mediator involved in inflammatory response (GO:0002532)3.07499872
92dendritic cell chemotaxis (GO:0002407)3.06785801
93cellular response to interferon-beta (GO:0035458)3.06146924
94translational elongation (GO:0006414)3.05942514
95response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.05910337
96response to host (GO:0075136)3.05910337
97response to host defenses (GO:0052200)3.05910337
98positive regulation of alpha-beta T cell proliferation (GO:0046641)3.05607502
99negative regulation of T-helper cell differentiation (GO:0045623)3.05523820
100negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.05523820
101regulation of leukocyte mediated cytotoxicity (GO:0001910)3.04899750
102regulation of myeloid leukocyte mediated immunity (GO:0002886)3.02014326
103thymic T cell selection (GO:0045061)3.00692921
104ribosomal small subunit biogenesis (GO:0042274)3.00228938
105negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.97447334
106SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.96964515
107antigen receptor-mediated signaling pathway (GO:0050851)2.96588468
108mature B cell differentiation (GO:0002335)2.96310555
109positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.95829855
110telomere maintenance via semi-conservative replication (GO:0032201)2.95467337
111dendritic cell migration (GO:0036336)2.95344791
112regulation of isotype switching to IgG isotypes (GO:0048302)2.94978620
113myeloid dendritic cell activation (GO:0001773)2.93499359
114platelet dense granule organization (GO:0060155)2.93113373
115lymphocyte homeostasis (GO:0002260)2.91607972
116tolerance induction (GO:0002507)2.90935842
117mast cell degranulation (GO:0043303)2.90107267
118mast cell activation involved in immune response (GO:0002279)2.90107267
119positive regulation of granulocyte differentiation (GO:0030854)2.89894045
120cotranslational protein targeting to membrane (GO:0006613)2.88163595
121regulation of interleukin-12 biosynthetic process (GO:0045075)2.88113634
122maturation of SSU-rRNA (GO:0030490)2.87113287
123negative regulation of phagocytosis (GO:0050765)2.86257876
124protein targeting to ER (GO:0045047)2.86239258
125T cell receptor signaling pathway (GO:0050852)2.85393438
126regulation of type I interferon-mediated signaling pathway (GO:0060338)2.82778029
127positive T cell selection (GO:0043368)2.81868814
128regulation of response to interferon-gamma (GO:0060330)2.79393514
129lymphoid progenitor cell differentiation (GO:0002320)2.79360848
130regulation of T cell mediated cytotoxicity (GO:0001914)2.76643801
131T cell selection (GO:0045058)2.75599344
132leukocyte homeostasis (GO:0001776)2.75522131
133nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.74852702
134lymph node development (GO:0048535)2.74656337
135regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.74536618
136protein localization to endoplasmic reticulum (GO:0070972)2.74242642
137regulation of regulatory T cell differentiation (GO:0045589)2.73824606
138positive regulation of T cell mediated cytotoxicity (GO:0001916)2.72308155
139viral life cycle (GO:0019058)2.72066007
140establishment of protein localization to endoplasmic reticulum (GO:0072599)2.71152069
141DNA strand elongation involved in DNA replication (GO:0006271)2.69214735
142interferon-gamma-mediated signaling pathway (GO:0060333)2.65822602
143regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.64727487
144regulation of natural killer cell mediated immunity (GO:0002715)2.64727487
145positive regulation of isotype switching (GO:0045830)2.64353955
146DNA strand elongation (GO:0022616)2.62144149
147lymphocyte costimulation (GO:0031294)2.61980457
148NIK/NF-kappaB signaling (GO:0038061)2.61886219
149telomere maintenance via recombination (GO:0000722)2.61373874
150T cell costimulation (GO:0031295)2.61267057
151regulation of B cell mediated immunity (GO:0002712)2.61150476
152negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.59824477
153regulation of erythrocyte differentiation (GO:0045646)2.59513350
154response to interferon-alpha (GO:0035455)2.58523983
155natural killer cell activation (GO:0030101)2.56931992
156germinal center formation (GO:0002467)2.56646417

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.71634217
2* IRF8_22096565_ChIP-ChIP_GC-B_Human3.81105679
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.41267496
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.35046123
5SCL_19346495_ChIP-Seq_HPC-7_Human3.32523755
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.31161332
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.27310129
8SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.98100605
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.89205726
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.84837950
11MYC_22102868_ChIP-Seq_BL_Human2.81902748
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.79006333
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.63499495
14FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.58740765
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56056266
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.55508903
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.48458337
18VDR_21846776_ChIP-Seq_THP-1_Human2.44492507
19TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.42488624
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.42304490
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.41967895
22* SPI1_23547873_ChIP-Seq_NB4_Human2.37289307
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32297881
24MYB_26560356_Chip-Seq_TH2_Human2.32097094
25* MAF_26560356_Chip-Seq_TH1_Human2.11596832
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.07980872
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.07864127
28SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.05750427
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05653067
30RUNX_20019798_ChIP-Seq_JUKART_Human2.02632744
31* MYB_26560356_Chip-Seq_TH1_Human2.00996174
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.98694980
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.98192107
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97610119
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.95354007
36* UTX_26944678_Chip-Seq_JUKART_Human1.92621303
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.92373372
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91900267
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90275947
40ERG_20887958_ChIP-Seq_HPC-7_Mouse1.88898122
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88661152
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.86785576
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84526939
44VDR_23849224_ChIP-Seq_CD4+_Human1.81804293
45VDR_24763502_ChIP-Seq_THP-1_Human1.80522595
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80182523
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76461090
48CIITA_25753668_ChIP-Seq_RAJI_Human1.70647302
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.69486519
50FOXP3_21729870_ChIP-Seq_TREG_Human1.68065778
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66295986
52GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.65966752
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.65655188
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64266991
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64043007
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59400758
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58175077
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.57594219
59VDR_24787735_ChIP-Seq_THP-1_Human1.56753327
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.56289114
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55401063
62MYC_18358816_ChIP-ChIP_MESCs_Mouse1.54057106
63TCF7_22412390_ChIP-Seq_EML_Mouse1.53806224
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53206530
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50714982
66GATA1_19941826_ChIP-Seq_K562_Human1.48956215
67* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48573000
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.48405093
69MAF_26560356_Chip-Seq_TH2_Human1.48325895
70GATA1_22025678_ChIP-Seq_K562_Human1.44490478
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44442729
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40044518
73GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39369671
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38889169
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.38704218
76HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38304160
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34057243
78SPI1_23127762_ChIP-Seq_K562_Human1.33768071
79* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31861131
80KDM2B_26808549_Chip-Seq_DND41_Human1.29431652
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28372313
82GATA3_27048872_Chip-Seq_THYMUS_Human1.28278240
83MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27616354
84XRN2_22483619_ChIP-Seq_HELA_Human1.26576817
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25740072
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24417535
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24227213
88FOXM1_23109430_ChIP-Seq_U2OS_Human1.23039884
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21245451
90CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18780014
91MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18163025
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16018018
93BCL6_27268052_Chip-Seq_Bcells_Human1.15340825
94SRF_21415370_ChIP-Seq_HL-1_Mouse1.15029831
95GABP_19822575_ChIP-Seq_HepG2_Human1.13963072
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13850321
97GATA2_19941826_ChIP-Seq_K562_Human1.12178317
98KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10953472
99PU_27001747_Chip-Seq_BMDM_Mouse1.10539547
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10384256
101VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09983582
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09073495
103GATA2_21666600_ChIP-Seq_HMVEC_Human1.09017114
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07960178
105PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06992449
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.05234454
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04888019
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04800105
109* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02195834
110NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02194969
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02065634
112E2F1_21310950_ChIP-Seq_MCF-7_Human1.01946145
113ELK1_19687146_ChIP-ChIP_HELA_Human0.98300874
114HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96882282
115DCP1A_22483619_ChIP-Seq_HELA_Human0.96810248
116GATA3_26560356_Chip-Seq_TH2_Human0.96227049
117SPI1_20517297_ChIP-Seq_HL60_Human0.94345509
118E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93757255
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93334104
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92664120
121BCOR_27268052_Chip-Seq_Bcells_Human0.91061199
122KDM2B_26808549_Chip-Seq_JURKAT_Human0.90746461
123* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88894920
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88781195
125TTF2_22483619_ChIP-Seq_HELA_Human0.88515531
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88073152
127GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87990783
128ETS1_22383799_ChIP-Seq_G1ME_Mouse0.87920444
129ELK3_25401928_ChIP-Seq_HUVEC_Human0.87194846
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85749235
131NCOR1_26117541_ChIP-Seq_K562_Human0.85637220
132NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85073258
133ELF1_20517297_ChIP-Seq_JURKAT_Human0.79617608
134RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79597655
135STAT1_20625510_ChIP-Seq_HELA_Human0.78312256
136STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78250550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.89758353
2MP0005671_abnormal_response_to3.89073468
3MP0002396_abnormal_hematopoietic_system3.64718597
4MP0003763_abnormal_thymus_physiology3.64020521
5MP0000685_abnormal_immune_system3.37407900
6MP0009785_altered_susceptibility_to2.99557315
7MP0001800_abnormal_humoral_immune2.89666692
8MP0002398_abnormal_bone_marrow2.68651580
9MP0005025_abnormal_response_to2.66269201
10MP0002420_abnormal_adaptive_immunity2.64841515
11MP0002723_abnormal_immune_serum2.62380592
12MP0001819_abnormal_immune_cell2.61683463
13MP0005000_abnormal_immune_tolerance2.60119760
14MP0002452_abnormal_antigen_presenting2.58684085
15MP0005464_abnormal_platelet_physiology2.57283350
16MP0005387_immune_system_phenotype2.44874250
17MP0001790_abnormal_immune_system2.44874250
18MP0002166_altered_tumor_susceptibility2.44258445
19MP0004808_abnormal_hematopoietic_stem2.42953515
20MP0003436_decreased_susceptibility_to2.36036363
21MP0000716_abnormal_immune_system2.31666656
22MP0000689_abnormal_spleen_morphology2.25665472
23MP0002419_abnormal_innate_immunity2.24488334
24MP0002722_abnormal_immune_system2.21808425
25MP0009333_abnormal_splenocyte_physiolog2.21555926
26MP0003724_increased_susceptibility_to2.21135943
27MP0005397_hematopoietic_system_phenotyp2.12495311
28MP0001545_abnormal_hematopoietic_system2.12495311
29MP0001873_stomach_inflammation2.12332133
30MP0008260_abnormal_autophagy2.10098788
31MP0005174_abnormal_tail_pigmentation2.09264944
32MP0000465_gastrointestinal_hemorrhage2.08518351
33MP0002148_abnormal_hypersensitivity_rea2.08475826
34MP0002405_respiratory_system_inflammati2.07657961
35MP0005075_abnormal_melanosome_morpholog2.04406250
36MP0002429_abnormal_blood_cell2.03593592
37MP0010155_abnormal_intestine_physiology2.01302051
38MP0002006_tumorigenesis1.98927295
39MP0006082_CNS_inflammation1.97469235
40MP0000703_abnormal_thymus_morphology1.96307114
41MP0001853_heart_inflammation1.92609678
42MP0000490_abnormal_crypts_of1.89135507
43MP0003866_abnormal_defecation1.85556232
44MP0003693_abnormal_embryo_hatching1.75312658
45MP0001845_abnormal_inflammatory_respons1.66359050
46MP0010094_abnormal_chromosome_stability1.48536981
47MP0008058_abnormal_DNA_repair1.42602379
48MP0004947_skin_inflammation1.40650862
49MP0002095_abnormal_skin_pigmentation1.38419163
50MP0002933_joint_inflammation1.36452706
51MP0004883_abnormal_blood_vessel1.35952971
52MP0008469_abnormal_protein_level1.34887318
53MP0008007_abnormal_cellular_replicative1.34634104
54MP0004510_myositis1.33387845
55MP0009278_abnormal_bone_marrow1.31956425
56MP0003077_abnormal_cell_cycle1.30730144
57MP0008057_abnormal_DNA_replication1.29109735
58MP0000015_abnormal_ear_pigmentation1.24777905
59MP0002019_abnormal_tumor_incidence1.23782533
60MP0003303_peritoneal_inflammation1.22461583
61MP0003191_abnormal_cellular_cholesterol1.22322879
62MP0008004_abnormal_stomach_pH1.22249992
63MP0000858_altered_metastatic_potential1.21518682
64MP0003172_abnormal_lysosome_physiology1.14079100
65MP0003300_gastrointestinal_ulcer1.12037816
66MP0005310_abnormal_salivary_gland1.07935073
67MP0002132_abnormal_respiratory_system1.06504828
68MP0005166_decreased_susceptibility_to1.06503045
69MP0001986_abnormal_taste_sensitivity1.05125086
70MP0001533_abnormal_skeleton_physiology1.04223893
71MP0003111_abnormal_nucleus_morphology1.03690757
72MP0002277_abnormal_respiratory_mucosa1.02699642
73MP0003690_abnormal_glial_cell1.01392701
74MP0004957_abnormal_blastocyst_morpholog1.01070490
75MP0005451_abnormal_body_composition0.98184467
76MP0005164_abnormal_response_to0.94547758
77MP0005058_abnormal_lysosome_morphology0.94305244
78MP0003075_altered_response_to0.93577388
79MP0004147_increased_porphyrin_level0.90488005
80MP0001851_eye_inflammation0.87958910
81MP0000313_abnormal_cell_death0.86767986
82MP0000343_altered_response_to0.85494483
83MP0003448_altered_tumor_morphology0.84778632
84MP0004130_abnormal_muscle_cell0.82364852
85MP0003943_abnormal_hepatobiliary_system0.80246118
86MP0009763_increased_sensitivity_to0.80224792
87MP0006054_spinal_hemorrhage0.73910864
88MP0005390_skeleton_phenotype0.72802806
89MP0003045_fibrosis0.71831479
90MP0009764_decreased_sensitivity_to0.71457683
91MP0000477_abnormal_intestine_morphology0.67655401
92MP0004381_abnormal_hair_follicle0.67461158
93MP0005083_abnormal_biliary_tract0.66323836
94MP0003656_abnormal_erythrocyte_physiolo0.64821006
95MP0009765_abnormal_xenobiotic_induced0.64547380
96MP0000604_amyloidosis0.63212450
97MP0000371_diluted_coat_color0.62754332
98MP0003806_abnormal_nucleotide_metabolis0.62013378
99MP0003828_pulmonary_edema0.61256882
100MP0001663_abnormal_digestive_system0.60569752
101MP0005023_abnormal_wound_healing0.58052152
102MP0003183_abnormal_peptide_metabolism0.56881821
103MP0003786_premature_aging0.56827335
104MP0008873_increased_physiological_sensi0.56432084
105MP0008874_decreased_physiological_sensi0.56401109
106MP0010352_gastrointestinal_tract_polyps0.56188836
107MP0002998_abnormal_bone_remodeling0.55281524
108MP0002138_abnormal_hepatobiliary_system0.54311319
109MP0006292_abnormal_olfactory_placode0.52384775
110MP0002075_abnormal_coat/hair_pigmentati0.50969412
111MP0005381_digestive/alimentary_phenotyp0.49944673
112MP0000598_abnormal_liver_morphology0.49539423
113MP0002693_abnormal_pancreas_physiology0.49151607
114MP0010307_abnormal_tumor_latency0.47169359
115MP0002009_preneoplasia0.46135301
116MP0000350_abnormal_cell_proliferation0.46018544
117MP0008877_abnormal_DNA_methylation0.45801374
118MP0003795_abnormal_bone_structure0.45324803
119MP0004185_abnormal_adipocyte_glucose0.44922057
120MP0000249_abnormal_blood_vessel0.43784354
121MP0009642_abnormal_blood_homeostasis0.43386090
122MP0003638_abnormal_response/metabolism_0.42628740
123MP0005376_homeostasis/metabolism_phenot0.42197947
124MP0003787_abnormal_imprinting0.42132265

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.36768925
2IgM deficiency (HP:0002850)5.24049066
3Myositis (HP:0100614)4.58525093
4Chronic otitis media (HP:0000389)4.45843881
5Thrombocytosis (HP:0001894)4.45042743
6Recurrent abscess formation (HP:0002722)4.25164664
7Recurrent bronchitis (HP:0002837)4.16437987
8Petechiae (HP:0000967)3.77417948
9Recurrent fungal infections (HP:0002841)3.71506128
10Gastrointestinal infarctions (HP:0005244)3.70933549
11Abnormality of T cells (HP:0002843)3.70646768
12Prolonged bleeding time (HP:0003010)3.69370161
13Aplastic anemia (HP:0001915)3.68987946
14Increased IgM level (HP:0003496)3.65364855
15Abnormality of T cell physiology (HP:0011840)3.62399284
16Recurrent bacterial skin infections (HP:0005406)3.57217364
17Panhypogammaglobulinemia (HP:0003139)3.55127654
18Recurrent viral infections (HP:0004429)3.55122362
19Eczematoid dermatitis (HP:0000976)3.50346259
20IgG deficiency (HP:0004315)3.43269092
21T lymphocytopenia (HP:0005403)3.40809105
22Keratoconjunctivitis sicca (HP:0001097)3.38519875
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.38294953
24Chronic mucocutaneous candidiasis (HP:0002728)3.36829939
25Recurrent cutaneous fungal infections (HP:0011370)3.36829939
26Nasal polyposis (HP:0100582)3.28429392
27Abnormality of T cell number (HP:0011839)3.25916147
28Lymphopenia (HP:0001888)3.23007613
29Abnormality of the nasal mucosa (HP:0000433)3.19633959
30Abnormal platelet volume (HP:0011876)3.18741187
31Keratoconjunctivitis (HP:0001096)3.17195000
32Epistaxis (HP:0000421)3.14587470
33Severe combined immunodeficiency (HP:0004430)3.14375072
34Abnormality of cells of the lymphoid lineage (HP:0012140)3.11481254
35Meningitis (HP:0001287)3.11427060
36Abnormal number of erythroid precursors (HP:0012131)3.08777241
37Abnormality of cells of the erythroid lineage (HP:0012130)3.08222188
38Abnormality of B cell number (HP:0010975)3.07619492
39B lymphocytopenia (HP:0010976)3.07619492
40Recurrent skin infections (HP:0001581)3.03466130
41Pulmonary infiltrates (HP:0002113)3.01086759
42Urticaria (HP:0001025)2.99920108
43Gingivitis (HP:0000230)2.94818984
44Combined immunodeficiency (HP:0005387)2.85501583
45Gastrointestinal inflammation (HP:0004386)2.84453643
46Agammaglobulinemia (HP:0004432)2.83980756
47Inflammation of the large intestine (HP:0002037)2.83522205
48Reticulocytopenia (HP:0001896)2.81729779
49Thyroiditis (HP:0100646)2.81057527
50Orchitis (HP:0100796)2.80072636
51Episodic fever (HP:0001954)2.78133764
52Mediastinal lymphadenopathy (HP:0100721)2.77723562
53Hypochromic microcytic anemia (HP:0004840)2.77632367
54Spontaneous hematomas (HP:0007420)2.76521407
55Pustule (HP:0200039)2.76108991
56Menorrhagia (HP:0000132)2.71587752
57Hypochromic anemia (HP:0001931)2.71548709
58Optic neuritis (HP:0100653)2.71501869
59Retrobulbar optic neuritis (HP:0100654)2.71501869
60Vasculitis (HP:0002633)2.70412592
61Stomatitis (HP:0010280)2.69377169
62Chronic diarrhea (HP:0002028)2.67833108
63Lymphoma (HP:0002665)2.67451655
64Abnormality of macrophages (HP:0004311)2.65218180
65Leukocytosis (HP:0001974)2.61884900
66Abnormal platelet function (HP:0011869)2.61569519
67Impaired platelet aggregation (HP:0003540)2.61569519
68Pulmonary embolism (HP:0002204)2.61428385
69Obstructive lung disease (HP:0006536)2.61286900
70Chronic obstructive pulmonary disease (HP:0006510)2.61286900
71Abnormality of eosinophils (HP:0001879)2.58268219
72Increased mean platelet volume (HP:0011877)2.57926952
73Joint swelling (HP:0001386)2.53037303
74Cellulitis (HP:0100658)2.52338978
75Granulocytopenia (HP:0001913)2.51737616
76Encephalitis (HP:0002383)2.51522467
77Anorexia (HP:0002039)2.49743943
78Type 2 muscle fiber atrophy (HP:0003554)2.48571263
79Recurrent sinusitis (HP:0011108)2.46998710
80Muscle fiber atrophy (HP:0100295)2.44212193
81Poikiloderma (HP:0001029)2.44196488
82Gingival bleeding (HP:0000225)2.43799760
83Abnormality of the prostate (HP:0008775)2.42949004
84Amaurosis fugax (HP:0100576)2.41693295
85Hypoplasia of the thymus (HP:0000778)2.38123988
86Bronchitis (HP:0012387)2.36801292
87Reduced antithrombin III activity (HP:0001976)2.33928828
88Abnormality of the fingertips (HP:0001211)2.31991154
89Microcytic anemia (HP:0001935)2.31854168
90Autoimmune hemolytic anemia (HP:0001890)2.30870353
91Gastrointestinal stroma tumor (HP:0100723)2.29871393
92Gangrene (HP:0100758)2.29704806
93Myelodysplasia (HP:0002863)2.29613429
94Osteomyelitis (HP:0002754)2.28272049
95Type I transferrin isoform profile (HP:0003642)2.28119716
96Purpura (HP:0000979)2.28000715
97Hemoptysis (HP:0002105)2.27880979
98Pallor (HP:0000980)2.24755688
99Colitis (HP:0002583)2.23624178
100Increased IgE level (HP:0003212)2.22975551
101Hypergammaglobulinemia (HP:0010702)2.21857937
102IgA deficiency (HP:0002720)2.20496270
103Eosinophilia (HP:0001880)2.20405156
104Acute myeloid leukemia (HP:0004808)2.19528448
105Vertigo (HP:0002321)2.19229958
106Interstitial pulmonary disease (HP:0006530)2.17790410
107Arterial thrombosis (HP:0004420)2.17631524
108Sepsis (HP:0100806)2.16783770
109Autoimmune thrombocytopenia (HP:0001973)2.16574370
110Chest pain (HP:0100749)2.13646642
111Albinism (HP:0001022)2.12756056
112Abnormality of the pleura (HP:0002103)2.12122952
113Abnormality of iron homeostasis (HP:0011031)2.11453593
114Acute hepatic failure (HP:0006554)2.07839621
115Increased serum ferritin (HP:0003281)2.07778841
116Chronic sinusitis (HP:0011109)2.07074432
117Abnormality of the heme biosynthetic pathway (HP:0010472)2.05610839
118Hyperlipoproteinemia (HP:0010980)2.05239818
119Hepatosplenomegaly (HP:0001433)2.04120924
120Basal cell carcinoma (HP:0002671)2.03896247
121Polyneuropathy (HP:0001271)2.03427644
122Recurrent gram-negative bacterial infections (HP:0005420)2.02784320
123Glomerulopathy (HP:0100820)2.01501890
124Agnosia (HP:0010524)2.01422880
125Vacuolated lymphocytes (HP:0001922)2.00476700
126Pancytopenia (HP:0001876)2.00300371
127Entropion (HP:0000621)1.99292670
128Abnormality of DNA repair (HP:0003254)1.98796452
129Papilloma (HP:0012740)1.97673619
130Verrucae (HP:0200043)1.97673619
131Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91406283
132Skin ulcer (HP:0200042)1.91012348
133Keratitis (HP:0000491)1.90565187
134Skin rash (HP:0000988)1.89836601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.71630436
2TXK3.55832098
3KIT3.07410209
4ZAP702.58667968
5JAK32.45736992
6TEC2.40431447
7BTK2.36546472
8TYK22.15051180
9IKBKE2.14140099
10BLK2.06281617
11FLT32.06260499
12IRAK42.03814114
13NME22.03444636
14TGFBR22.03152933
15TBK12.03069158
16EEF2K1.95538876
17CSF1R1.92126661
18PRPF4B1.82321622
19ACVR1B1.80264386
20KDR1.79926875
21ITK1.69701015
22STK101.67771122
23SYK1.67551228
24STK161.62979732
25EPHB11.62212745
26TGFBR11.58305243
27FGR1.53511216
28MAP3K121.52205831
29LCK1.49574535
30PIK3CG1.42338975
31NLK1.38344905
32MAP2K31.37869839
33TNIK1.33504957
34IKBKB1.31003268
35WEE11.27906507
36FES1.25934126
37FGFR41.22267417
38MAP3K31.19530262
39GRK61.18252737
40TAOK11.16801912
41PIM21.14430594
42HCK1.14335933
43LYN1.11999175
44BMPR21.11748922
45MAP3K141.08980656
46JAK11.08624471
47RPS6KA41.05653066
48MUSK1.04630982
49CLK11.04342097
50TAOK31.03220141
51RPS6KB20.99944474
52PIM10.99397424
53MAP3K130.99371973
54CDK190.98505090
55LRRK20.97860858
56TNK20.96544854
57VRK10.91224783
58CSK0.88469237
59CAMKK20.88346429
60MAP3K10.85164709
61PRKCQ0.83871691
62SIK30.83611396
63MATK0.83086681
64CDC70.82685158
65TESK20.80036232
66PDK10.80006971
67BRSK20.78621716
68FGFR30.78353731
69IRAK10.77879744
70IRAK30.77586016
71PTK2B0.76943083
72NEK20.76132819
73BUB10.75491691
74MAP2K60.74946631
75AKT30.72619093
76YES10.72534092
77CDK40.70015773
78TAOK20.69509608
79SCYL20.69245169
80PKN20.68722529
81ATR0.67468173
82MAPKAPK30.67193111
83ADRBK20.66813643
84CDK80.65987814
85FYN0.65036515
86EIF2AK10.64263434
87CAMKK10.63209103
88SIK20.62629160
89EIF2AK30.62622589
90MARK30.62455255
91CCNB10.60517553
92ERN10.59920435
93MAPK110.59662426
94MAPK120.58080827
95PAK40.55324690
96EPHA30.54592266
97DYRK30.54434497
98PDPK10.53369243
99SGK20.52721602
100CDK70.52369367
101MAP3K50.51356156
102GRK70.51230033
103MAPKAPK50.49446563
104TSSK60.49072476
105RIPK40.48820484
106PASK0.48115520
107MARK20.47626488
108BMX0.47390092
109PRKD20.46949220
110CHUK0.46776682
111SGK30.46391464
112JAK20.46086168
113MAPK40.44961147
114MAP3K110.43686042
115IRAK20.43091504
116STK110.42417440
117RAF10.41237608
118TAF10.40708557
119TLK10.39102204
120MKNK10.39009707
121MAP3K100.38414172
122PRKG20.38332323
123HIPK20.38291410
124MAPKAPK20.38108884
125PTK60.38004657
126CAMK10.36752592
127MAP3K70.36249585
128DAPK10.36064461
129MAPK70.35360248
130RET0.35249732
131MAP3K60.34636650
132STK40.34592038
133KSR10.32793367
134MAP2K20.32473915
135ILK0.32349976
136RPS6KA60.31811611
137MAP3K80.31311830
138DYRK1B0.29622210
139KSR20.29044000
140PRKCD0.29011512
141MAP2K40.27508098
142ABL10.26940149
143GRK50.26883102
144RPS6KC10.26587729
145RPS6KL10.26587729
146RIPK10.26230645

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.01767616
2DNA replication_Homo sapiens_hsa030303.32324287
3Ribosome_Homo sapiens_hsa030102.93609347
4Mismatch repair_Homo sapiens_hsa034302.51015112
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.37748671
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.31061131
7Measles_Homo sapiens_hsa051622.26671604
8Base excision repair_Homo sapiens_hsa034102.20620404
9Antigen processing and presentation_Homo sapiens_hsa046122.20193150
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.13624312
11Leishmaniasis_Homo sapiens_hsa051402.12753356
12Hematopoietic cell lineage_Homo sapiens_hsa046402.11813463
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.07982115
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.07237343
15B cell receptor signaling pathway_Homo sapiens_hsa046622.00733928
16Type I diabetes mellitus_Homo sapiens_hsa049402.00269176
17T cell receptor signaling pathway_Homo sapiens_hsa046601.88817638
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.82592107
19Homologous recombination_Homo sapiens_hsa034401.80976989
20Herpes simplex infection_Homo sapiens_hsa051681.77589354
21Nucleotide excision repair_Homo sapiens_hsa034201.66117691
22Osteoclast differentiation_Homo sapiens_hsa043801.64765938
23Spliceosome_Homo sapiens_hsa030401.59397675
24Other glycan degradation_Homo sapiens_hsa005111.57770746
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.52257018
26Pyrimidine metabolism_Homo sapiens_hsa002401.45234737
27Non-homologous end-joining_Homo sapiens_hsa034501.44386678
28Allograft rejection_Homo sapiens_hsa053301.43426376
29Shigellosis_Homo sapiens_hsa051311.33474823
30RNA polymerase_Homo sapiens_hsa030201.32243554
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27497054
32Proteasome_Homo sapiens_hsa030501.26550451
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23427805
34Acute myeloid leukemia_Homo sapiens_hsa052211.22505174
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21453789
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17772242
37Influenza A_Homo sapiens_hsa051641.16666925
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14075137
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13585455
40Legionellosis_Homo sapiens_hsa051341.12939292
41Rheumatoid arthritis_Homo sapiens_hsa053231.12147256
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11517351
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11263402
44Hepatitis B_Homo sapiens_hsa051611.09525899
45Phagosome_Homo sapiens_hsa041451.08752832
46Platelet activation_Homo sapiens_hsa046111.08001152
47Graft-versus-host disease_Homo sapiens_hsa053321.07998736
48RNA degradation_Homo sapiens_hsa030181.07484306
49Fanconi anemia pathway_Homo sapiens_hsa034601.07121412
50African trypanosomiasis_Homo sapiens_hsa051431.03410602
51Epstein-Barr virus infection_Homo sapiens_hsa051691.02846395
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01569075
53Pertussis_Homo sapiens_hsa051331.01503203
54Toxoplasmosis_Homo sapiens_hsa051450.99964186
55Cell cycle_Homo sapiens_hsa041100.98627828
56Apoptosis_Homo sapiens_hsa042100.97990082
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94495343
58Malaria_Homo sapiens_hsa051440.93984552
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.92931545
60Asthma_Homo sapiens_hsa053100.91764672
61Staphylococcus aureus infection_Homo sapiens_hsa051500.90919595
62Viral myocarditis_Homo sapiens_hsa054160.88454830
63Chemokine signaling pathway_Homo sapiens_hsa040620.87450989
64Tuberculosis_Homo sapiens_hsa051520.87352697
65p53 signaling pathway_Homo sapiens_hsa041150.86510598
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85736519
67Basal transcription factors_Homo sapiens_hsa030220.84622441
68RNA transport_Homo sapiens_hsa030130.83128983
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.81954471
70Regulation of autophagy_Homo sapiens_hsa041400.79759034
71HTLV-I infection_Homo sapiens_hsa051660.78769860
72N-Glycan biosynthesis_Homo sapiens_hsa005100.76586678
73Viral carcinogenesis_Homo sapiens_hsa052030.74594017
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74532877
75Endocytosis_Homo sapiens_hsa041440.74250327
76VEGF signaling pathway_Homo sapiens_hsa043700.71984899
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71076448
78Sulfur relay system_Homo sapiens_hsa041220.70845683
79TNF signaling pathway_Homo sapiens_hsa046680.70567325
80Salmonella infection_Homo sapiens_hsa051320.68333963
81Pancreatic cancer_Homo sapiens_hsa052120.66723733
82Chronic myeloid leukemia_Homo sapiens_hsa052200.64788627
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64152214
84Autoimmune thyroid disease_Homo sapiens_hsa053200.63874835
85Purine metabolism_Homo sapiens_hsa002300.63711459
86Pentose phosphate pathway_Homo sapiens_hsa000300.63689353
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62584132
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61985306
89Hepatitis C_Homo sapiens_hsa051600.60956423
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60303640
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57894885
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.55796406
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55629699
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53950978
95FoxO signaling pathway_Homo sapiens_hsa040680.53639568
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52683417
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51804004
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.51699870
99Colorectal cancer_Homo sapiens_hsa052100.51271131
100Protein export_Homo sapiens_hsa030600.49846701
101Renal cell carcinoma_Homo sapiens_hsa052110.49705364
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48740875
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48501456
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48443944
105Folate biosynthesis_Homo sapiens_hsa007900.47450491
106Notch signaling pathway_Homo sapiens_hsa043300.46120601
107Choline metabolism in cancer_Homo sapiens_hsa052310.45521619
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45227749
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.43273959
110Caffeine metabolism_Homo sapiens_hsa002320.42664564
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42388124
112Thyroid cancer_Homo sapiens_hsa052160.42232769
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.40979612
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39614612
115Lysosome_Homo sapiens_hsa041420.39306208
116Endometrial cancer_Homo sapiens_hsa052130.39135066
117MAPK signaling pathway_Homo sapiens_hsa040100.38580656
118Arachidonic acid metabolism_Homo sapiens_hsa005900.38558959
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38387842
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.38276669
121One carbon pool by folate_Homo sapiens_hsa006700.38023521
122Systemic lupus erythematosus_Homo sapiens_hsa053220.37772553
123Amoebiasis_Homo sapiens_hsa051460.37350055
124Non-small cell lung cancer_Homo sapiens_hsa052230.36753215
125mTOR signaling pathway_Homo sapiens_hsa041500.35244807
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.35146514
127Rap1 signaling pathway_Homo sapiens_hsa040150.34963672
128Prolactin signaling pathway_Homo sapiens_hsa049170.34726360
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34163844
130Inositol phosphate metabolism_Homo sapiens_hsa005620.32883060
131Dorso-ventral axis formation_Homo sapiens_hsa043200.31128729
132GnRH signaling pathway_Homo sapiens_hsa049120.30396693
133Long-term potentiation_Homo sapiens_hsa047200.29054263
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27848745
135Insulin resistance_Homo sapiens_hsa049310.27602349
136HIF-1 signaling pathway_Homo sapiens_hsa040660.27268476

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »