BIN2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.38136275
2DNA deamination (GO:0045006)6.78311542
3cytidine deamination (GO:0009972)6.59909474
4cytidine metabolic process (GO:0046087)6.59909474
5cytidine catabolic process (GO:0006216)6.59909474
6Arp2/3 complex-mediated actin nucleation (GO:0034314)6.22302850
7pyrimidine ribonucleoside catabolic process (GO:0046133)5.85698379
8regulation of gamma-delta T cell differentiation (GO:0045586)5.54587381
9actin nucleation (GO:0045010)5.51846756
10positive regulation of natural killer cell mediated immunity (GO:0002717)5.41668179
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.35549453
12negative T cell selection (GO:0043383)5.33098493
13positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.23976884
14regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.02794208
15regulation of natural killer cell mediated immunity (GO:0002715)5.02794208
16positive regulation of gamma-delta T cell activation (GO:0046645)5.01317658
17regulation of B cell receptor signaling pathway (GO:0050855)4.91082243
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.80403407
19regulation of gamma-delta T cell activation (GO:0046643)4.72464390
20negative thymic T cell selection (GO:0045060)4.69973468
21negative regulation of T cell apoptotic process (GO:0070233)4.61400152
22positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.61057973
23positive T cell selection (GO:0043368)4.58817521
24positive thymic T cell selection (GO:0045059)4.45603426
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.29688921
26negative regulation of cell killing (GO:0031342)4.29688921
27regulation of leukocyte mediated cytotoxicity (GO:0001910)4.28378030
28thymic T cell selection (GO:0045061)4.27983815
29cellular response to interleukin-15 (GO:0071350)4.22984975
30T cell migration (GO:0072678)4.19720367
31positive regulation of B cell differentiation (GO:0045579)4.19626564
32regulation of regulatory T cell differentiation (GO:0045589)4.18572221
33negative regulation of stress fiber assembly (GO:0051497)4.12349557
34positive regulation of cell killing (GO:0031343)4.02399400
35regulation of T cell receptor signaling pathway (GO:0050856)3.98460346
36positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.97251739
37positive regulation of tolerance induction (GO:0002645)3.91928652
38regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.89689643
39T cell selection (GO:0045058)3.82941265
40ncRNA 3-end processing (GO:0043628)3.82787596
41regulation of cell killing (GO:0031341)3.79213278
42negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.78746113
43regulation of B cell differentiation (GO:0045577)3.78313724
44positive regulation of T cell mediated cytotoxicity (GO:0001916)3.74197619
45cytolysis (GO:0019835)3.73660722
46T cell receptor signaling pathway (GO:0050852)3.68806650
47negative regulation of viral genome replication (GO:0045071)3.65597578
48regulation of T cell tolerance induction (GO:0002664)3.64155918
49positive regulation of alpha-beta T cell proliferation (GO:0046641)3.58535781
50regulation of activation of Janus kinase activity (GO:0010533)3.56285288
51positive regulation of calcium-mediated signaling (GO:0050850)3.56026558
52sequestering of actin monomers (GO:0042989)3.48316614
53response to interleukin-15 (GO:0070672)3.42836611
54negative regulation of lymphocyte apoptotic process (GO:0070229)3.41430262
55deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.39382641
56regulation of T cell mediated cytotoxicity (GO:0001914)3.38264067
57T cell costimulation (GO:0031295)3.36649291
58pyrimidine nucleoside catabolic process (GO:0046135)3.33667764
59lymphocyte costimulation (GO:0031294)3.32706621
60regulation of alpha-beta T cell proliferation (GO:0046640)3.29225317
61antigen receptor-mediated signaling pathway (GO:0050851)3.27546755
62antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.27319930
63activated T cell proliferation (GO:0050798)3.26078212
64negative regulation of actin filament bundle assembly (GO:0032232)3.19322621
65positive regulation of defense response to virus by host (GO:0002230)3.18974268
66regulation of tolerance induction (GO:0002643)3.15349076
67negative regulation by host of viral transcription (GO:0043922)3.12702610
68antigen processing and presentation of endogenous antigen (GO:0019883)3.11885569
69positive regulation of granulocyte differentiation (GO:0030854)3.09470779
70positive regulation of interleukin-4 production (GO:0032753)3.07085036
71regulation of interleukin-2 biosynthetic process (GO:0045076)3.04662400
72immunoglobulin mediated immune response (GO:0016064)3.04502887
73regulation of interleukin-12 biosynthetic process (GO:0045075)3.04497024
74regulation of T cell apoptotic process (GO:0070232)3.01042890
75negative regulation of T cell receptor signaling pathway (GO:0050860)2.97451385
76antigen processing and presentation via MHC class Ib (GO:0002475)2.97367913
77leukocyte aggregation (GO:0070486)2.94980751
78mast cell activation (GO:0045576)2.94700746
79cellular defense response (GO:0006968)2.94592035
80response to interferon-beta (GO:0035456)2.93348058
81positive regulation of lymphocyte mediated immunity (GO:0002708)2.91635821
82lymphocyte migration (GO:0072676)2.90154221
83positive regulation of lamellipodium assembly (GO:0010592)2.88908859
84positive regulation of interleukin-8 secretion (GO:2000484)2.88458061
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.87239824
86dendritic cell chemotaxis (GO:0002407)2.86202060
87positive regulation of T cell chemotaxis (GO:0010820)2.81487826
88regulation of T cell chemotaxis (GO:0010819)2.81487826
89mucosal-associated lymphoid tissue development (GO:0048537)2.78103486
90Peyers patch development (GO:0048541)2.78103486
91negative regulation of leukocyte apoptotic process (GO:2000107)2.77804853
92adaptation of signaling pathway (GO:0023058)2.76907977
93positive regulation of T cell mediated immunity (GO:0002711)2.75930972
94production of molecular mediator involved in inflammatory response (GO:0002532)2.75574086
95positive regulation of chemokine secretion (GO:0090197)2.75473426
96ribosomal small subunit assembly (GO:0000028)2.74888728
97macrophage chemotaxis (GO:0048246)2.73771625
98chemokine-mediated signaling pathway (GO:0070098)2.70831378
99antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70086569
100positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.66601811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.47903742
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.01140957
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.67137533
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.65589785
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.43355113
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.55924157
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.39681874
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.08316994
9RUNX_20019798_ChIP-Seq_JUKART_Human2.87980058
10MYB_26560356_Chip-Seq_TH2_Human2.83381487
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.61583079
12LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.61545293
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.59124940
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58375120
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32517920
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26864571
17GATA3_27048872_Chip-Seq_THYMUS_Human2.24786518
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15635099
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.07991899
20GATA3_26560356_Chip-Seq_TH2_Human1.94751518
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.85325889
22MYB_26560356_Chip-Seq_TH1_Human1.83297495
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82900945
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81764871
25UTX_26944678_Chip-Seq_JUKART_Human1.76714210
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76662356
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.76563072
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.65806585
29MAF_26560356_Chip-Seq_TH1_Human1.63412311
30VDR_22108803_ChIP-Seq_LS180_Human1.62802838
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60484878
32GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.55598103
33SPI1_23547873_ChIP-Seq_NB4_Human1.54990467
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51661872
35BCL6_27268052_Chip-Seq_Bcells_Human1.50570543
36EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.48727605
37EZH2_22144423_ChIP-Seq_EOC_Human1.46778598
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.45102180
39MAF_26560356_Chip-Seq_TH2_Human1.41304959
40RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.36467768
41VDR_23849224_ChIP-Seq_CD4+_Human1.36238664
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31992299
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.29004794
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27887393
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24699238
46PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.24665630
47NANOG_20526341_ChIP-Seq_ESCs_Human1.24377409
48AR_20517297_ChIP-Seq_VCAP_Human1.23627961
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21014666
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20777315
51VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19550440
52TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19393736
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.17835664
54HTT_18923047_ChIP-ChIP_STHdh_Human1.13840755
55P300_27268052_Chip-Seq_Bcells_Human1.13727485
56EGR1_19032775_ChIP-ChIP_M12_Human1.12267211
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11700851
58SCL_19346495_ChIP-Seq_HPC-7_Human1.09827284
59TAF2_19829295_ChIP-Seq_ESCs_Human1.08945651
60RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04147110
61IGF1R_20145208_ChIP-Seq_DFB_Human1.03201647
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.02704665
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02704665
64RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02440144
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01054211
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00825625
67BCOR_27268052_Chip-Seq_Bcells_Human0.97027576
68GATA3_26560356_Chip-Seq_TH1_Human0.96945341
69ERA_21632823_ChIP-Seq_H3396_Human0.96798993
70SPI1_20517297_ChIP-Seq_HL60_Human0.96509480
71NCOR_22424771_ChIP-Seq_293T_Human0.95891909
72ELF1_20517297_ChIP-Seq_JURKAT_Human0.95261529
73RUNX1_22412390_ChIP-Seq_EML_Mouse0.95185706
74BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94128878
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93965516
76EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93599117
77TP53_22573176_ChIP-Seq_HFKS_Human0.92500650
78IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92159841
79CTCF_20526341_ChIP-Seq_ESCs_Human0.91611800
80GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91204501
81EST1_17652178_ChIP-ChIP_JURKAT_Human0.90922349
82SRF_21415370_ChIP-Seq_HL-1_Mouse0.90050516
83GATA3_21878914_ChIP-Seq_MCF-7_Human0.89872517
84YY1_22570637_ChIP-Seq_MALME-3M_Human0.89208277
85GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88499432
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88381347
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87479448
88TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86352545
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85768053
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85478574
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84089290
92GATA6_21074721_ChIP-Seq_CACO-2_Human0.83478365
93ERG_20517297_ChIP-Seq_VCAP_Human0.83265444
94SPI1_23127762_ChIP-Seq_K562_Human0.82687595
95PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82209647
96MYC_19829295_ChIP-Seq_ESCs_Human0.81682225
97TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.81593027
98STAT1_20625510_ChIP-Seq_HELA_Human0.81423266
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.80551935
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.80531651

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.50551040
2MP0009785_altered_susceptibility_to3.70545106
3MP0001835_abnormal_antigen_presentation3.48824365
4MP0003763_abnormal_thymus_physiology3.28737128
5MP0006082_CNS_inflammation3.27073369
6MP0001873_stomach_inflammation3.02201606
7MP0005000_abnormal_immune_tolerance2.86848869
8MP0001800_abnormal_humoral_immune2.75700578
9MP0009333_abnormal_splenocyte_physiolog2.61445547
10MP0002166_altered_tumor_susceptibility2.60881387
11MP0005025_abnormal_response_to2.51424847
12MP0002420_abnormal_adaptive_immunity2.49030082
13MP0002723_abnormal_immune_serum2.48814737
14MP0004510_myositis2.48355690
15MP0002933_joint_inflammation2.44337965
16MP0001819_abnormal_immune_cell2.42493263
17MP0003866_abnormal_defecation2.34282083
18MP0003724_increased_susceptibility_to2.34214319
19MP0000685_abnormal_immune_system2.33828355
20MP0002148_abnormal_hypersensitivity_rea2.32935808
21MP0003436_decreased_susceptibility_to2.26940208
22MP0002452_abnormal_antigen_presenting2.19316247
23MP0005387_immune_system_phenotype2.14139804
24MP0001790_abnormal_immune_system2.14139804
25MP0002006_tumorigenesis2.05749192
26MP0002405_respiratory_system_inflammati2.02157761
27MP0002398_abnormal_bone_marrow1.99781646
28MP0010155_abnormal_intestine_physiology1.98707906
29MP0005464_abnormal_platelet_physiology1.93635716
30MP0002419_abnormal_innate_immunity1.88137315
31MP0000716_abnormal_immune_system1.86912754
32MP0000689_abnormal_spleen_morphology1.80818150
33MP0004947_skin_inflammation1.77986817
34MP0000703_abnormal_thymus_morphology1.76966312
35MP0005377_hearing/vestibular/ear_phenot1.74353113
36MP0003878_abnormal_ear_physiology1.74353113
37MP0005075_abnormal_melanosome_morpholog1.73160968
38MP0003879_abnormal_hair_cell1.71792152
39MP0002722_abnormal_immune_system1.69598221
40MP0001845_abnormal_inflammatory_respons1.67771638
41MP0001533_abnormal_skeleton_physiology1.60478440
42MP0002429_abnormal_blood_cell1.45358402
43MP0008875_abnormal_xenobiotic_pharmacok1.30197150
44MP0009764_decreased_sensitivity_to1.28569987
45MP0002876_abnormal_thyroid_physiology1.28489598
46MP0008469_abnormal_protein_level1.18537964
47MP0005645_abnormal_hypothalamus_physiol1.16175088
48MP0002102_abnormal_ear_morphology1.14393622
49MP0001853_heart_inflammation1.11942641
50MP0002163_abnormal_gland_morphology1.11266935
51MP0001727_abnormal_embryo_implantation1.09137476
52MP0008872_abnormal_physiological_respon1.08538126
53MP0003448_altered_tumor_morphology1.05890666
54MP0005646_abnormal_pituitary_gland1.05497646
55MP0005084_abnormal_gallbladder_morpholo1.05195960
56MP0005551_abnormal_eye_electrophysiolog1.04289674
57MP0003195_calcinosis1.02954969
58MP0003252_abnormal_bile_duct1.02400690
59MP0001968_abnormal_touch/_nociception1.01312033
60MP0000015_abnormal_ear_pigmentation0.95613286
61MP0009763_increased_sensitivity_to0.95395147
62MP0001905_abnormal_dopamine_level0.92795002
63MP0002019_abnormal_tumor_incidence0.87536001
64MP0000465_gastrointestinal_hemorrhage0.87382934
65MP0001663_abnormal_digestive_system0.86628937
66MP0003806_abnormal_nucleotide_metabolis0.86260344
67MP0000858_altered_metastatic_potential0.85825487
68MP0003646_muscle_fatigue0.83691346
69MP0005166_decreased_susceptibility_to0.83225693
70MP0009765_abnormal_xenobiotic_induced0.80686893
71MP0005083_abnormal_biliary_tract0.79809352
72MP0001986_abnormal_taste_sensitivity0.79616844
73MP0005174_abnormal_tail_pigmentation0.79169765
74MP0000372_irregular_coat_pigmentation0.78436684
75MP0002736_abnormal_nociception_after0.77722004
76MP0005410_abnormal_fertilization0.76398256
77MP0003045_fibrosis0.76234610
78MP0001765_abnormal_ion_homeostasis0.75845320
79MP0001851_eye_inflammation0.75565427
80MP0002837_dystrophic_cardiac_calcinosis0.74161893
81MP0006072_abnormal_retinal_apoptosis0.74069787
82MP0003011_delayed_dark_adaptation0.73822710
83MP0002277_abnormal_respiratory_mucosa0.72806579
84MP0002138_abnormal_hepatobiliary_system0.71295437
85MP0001919_abnormal_reproductive_system0.71246329
86MP0001501_abnormal_sleep_pattern0.71116253
87MP0004381_abnormal_hair_follicle0.70655595
88MP0005310_abnormal_salivary_gland0.69245695
89MP0001764_abnormal_homeostasis0.69090594
90MP0002693_abnormal_pancreas_physiology0.68682668
91MP0005390_skeleton_phenotype0.67449052
92MP0005085_abnormal_gallbladder_physiolo0.64046387
93MP0009643_abnormal_urine_homeostasis0.63878388
94MP0002095_abnormal_skin_pigmentation0.62555942
95MP0010386_abnormal_urinary_bladder0.61805789
96MP0004885_abnormal_endolymph0.60339991
97MP0005379_endocrine/exocrine_gland_phen0.58148096
98MP0002136_abnormal_kidney_physiology0.57010280
99MP0002998_abnormal_bone_remodeling0.56892249
100MP0005389_reproductive_system_phenotype0.56053796

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)5.24374486
2IgG deficiency (HP:0004315)5.13981220
3Abnormality of T cell number (HP:0011839)5.07137221
4T lymphocytopenia (HP:0005403)5.04502896
5Aplastic anemia (HP:0001915)4.94060199
6Autoimmune hemolytic anemia (HP:0001890)4.73509945
7Severe combined immunodeficiency (HP:0004430)4.64564444
8Elevated erythrocyte sedimentation rate (HP:0003565)4.47529797
9Attenuation of retinal blood vessels (HP:0007843)4.34152484
10Hypoproteinemia (HP:0003075)4.20446086
11Stomatitis (HP:0010280)4.03757251
12Constricted visual fields (HP:0001133)4.03028033
13Decreased electroretinogram (ERG) amplitude (HP:0000654)3.85775153
14Abnormality of macular pigmentation (HP:0008002)3.78265624
15Abnormality of T cells (HP:0002843)3.67194071
16Striae distensae (HP:0001065)3.66968574
17Combined immunodeficiency (HP:0005387)3.66853275
18Abnormality of eosinophils (HP:0001879)3.50341346
19Abnormality of the prostate (HP:0008775)3.33491931
20Metaphyseal cupping (HP:0003021)3.30126908
21Thyroiditis (HP:0100646)3.25315276
22Absent rod-and cone-mediated responses on ERG (HP:0007688)3.15261406
23Eosinophilia (HP:0001880)3.13817023
24Myositis (HP:0100614)3.05017802
25Encephalitis (HP:0002383)3.04892340
26Round ear (HP:0100830)2.98484696
27Abnormality of B cell number (HP:0010975)2.95104011
28Toxemia of pregnancy (HP:0100603)2.92674076
29IgM deficiency (HP:0002850)2.90270894
30Leukocytosis (HP:0001974)2.83166294
31Severe visual impairment (HP:0001141)2.80079187
32Congenital stationary night blindness (HP:0007642)2.79844904
33Granulocytopenia (HP:0001913)2.77912121
34Cupped ribs (HP:0000887)2.75595140
35Autoimmune thrombocytopenia (HP:0001973)2.74833176
36Hypergammaglobulinemia (HP:0010702)2.71472668
37Cone-rod dystrophy (HP:0000548)2.68665135
38Chronic diarrhea (HP:0002028)2.68468098
39Decreased central vision (HP:0007663)2.64476984
40Pancytopenia (HP:0001876)2.63178413
41Recurrent otitis media (HP:0000403)2.61019150
42Lymphopenia (HP:0001888)2.58100839
43Meningitis (HP:0001287)2.56527088
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.55739685
45Abnormality of cells of the lymphoid lineage (HP:0012140)2.54135032
46Recurrent bronchitis (HP:0002837)2.53525466
47B lymphocytopenia (HP:0010976)2.53165927
48Obstructive lung disease (HP:0006536)2.38378690
49Chronic obstructive pulmonary disease (HP:0006510)2.38378690
50Prostate neoplasm (HP:0100787)2.34755217
51Recurrent fungal infections (HP:0002841)2.32554345
52Abnormal rod and cone electroretinograms (HP:0008323)2.31547834
53Optic disc pallor (HP:0000543)2.31281551
54Pustule (HP:0200039)2.30933600
55Pulmonary infiltrates (HP:0002113)2.30576819
56Joint swelling (HP:0001386)2.30563055
57Hemiplegia (HP:0002301)2.30041083
58Acute hepatic failure (HP:0006554)2.29353511
59Abnormality of macrophages (HP:0004311)2.28766840
60Volvulus (HP:0002580)2.27045774
61Abnormality of T cell physiology (HP:0011840)2.26185121
62Vasculitis (HP:0002633)2.24492295
63Retrobulbar optic neuritis (HP:0100654)2.21977198
64Optic neuritis (HP:0100653)2.21977198
65Abolished electroretinogram (ERG) (HP:0000550)2.20932161
66Amyotrophic lateral sclerosis (HP:0007354)2.20863283
67Mitochondrial inheritance (HP:0001427)2.20120778
68Oral leukoplakia (HP:0002745)2.12712763
69Panhypogammaglobulinemia (HP:0003139)2.08958126
70Gingival bleeding (HP:0000225)2.08925189
71Recurrent abscess formation (HP:0002722)2.07957164
72Agammaglobulinemia (HP:0004432)2.05778662
73Pulmonary fibrosis (HP:0002206)2.04710922
74Epistaxis (HP:0000421)2.04611470
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02930667
76Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02930667
77Prolonged bleeding time (HP:0003010)2.02636936
78Lymphoma (HP:0002665)2.00947502
79Gangrene (HP:0100758)2.00380250
80Mediastinal lymphadenopathy (HP:0100721)1.99707028
81Chest pain (HP:0100749)1.98004476
82Gastrointestinal infarctions (HP:0005244)1.97205177
83Abnormal albumin level (HP:0012116)1.96084673
84Hypoalbuminemia (HP:0003073)1.96084673
85Bronchitis (HP:0012387)1.95881057
86Keratoconjunctivitis sicca (HP:0001097)1.95372892
87Recurrent cutaneous fungal infections (HP:0011370)1.95319718
88Chronic mucocutaneous candidiasis (HP:0002728)1.95319718
89Recurrent viral infections (HP:0004429)1.92393592
90Orchitis (HP:0100796)1.92390160
91Abnormal mitochondria in muscle tissue (HP:0008316)1.91942551
92Pulmonary embolism (HP:0002204)1.89851322
93Acute necrotizing encephalopathy (HP:0006965)1.89497168
94Keratoconjunctivitis (HP:0001096)1.88714215
95Recurrent bacterial skin infections (HP:0005406)1.84475421
963-Methylglutaconic aciduria (HP:0003535)1.84013795
97Generalized aminoaciduria (HP:0002909)1.83797582
98Hemoptysis (HP:0002105)1.83423882
99Lack of skin elasticity (HP:0100679)1.82406471
100Abnormality of male internal genitalia (HP:0000022)1.76356185

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.17051747
2TXK4.74928092
3TESK24.69553854
4MAP4K13.61629649
5KIT3.55956942
6BCKDK3.36211636
7FES3.08481980
8TEC2.91640506
9TAOK32.65623724
10ITK2.34837471
11TESK12.22968776
12SYK2.08991333
13GRK62.01162977
14LIMK11.98337474
15TLK11.96790831
16MAPKAPK31.91329641
17BTK1.79409909
18ZAK1.65872542
19IKBKB1.58195252
20ADRBK21.56723276
21CSK1.52390234
22IKBKE1.50623359
23ZAP701.46775976
24CSF1R1.38654400
25LCK1.37664899
26MAP3K121.35293221
27SCYL21.30332559
28MAP3K111.22723614
29PRKCQ1.21131618
30TBK11.14817459
31LYN1.13077362
32MAP3K141.10859519
33PASK1.10056907
34GRK11.09268615
35VRK21.07166162
36MUSK1.02159182
37DAPK11.01760768
38MAP4K20.91489485
39VRK10.91117724
40GRK70.90322072
41JAK30.79499480
42TNK20.79126862
43RIPK40.75981109
44PIM10.73278355
45PIK3CG0.70633988
46MYLK0.70370139
47FRK0.69777386
48ADRBK10.69129121
49STK160.68402417
50NUAK10.67866046
51HCK0.67245872
52CAMKK10.66848223
53PIM20.65722874
54CDK190.63842859
55CAMKK20.62602401
56FYN0.60110122
57MAP2K20.57722213
58WNK40.55627670
59BMPR20.54737779
60GRK50.54146796
61NME10.53524592
62IGF1R0.52576894
63INSR0.50565716
64MATK0.49166457
65TYRO30.46866170
66MAP3K50.46018293
67ABL10.44998139
68INSRR0.44684081
69TRPM70.43536966
70RPS6KA50.41859583
71OBSCN0.41067346
72CLK10.40936012
73RPS6KA40.38410293
74TIE10.38293442
75MAP2K60.38161870
76PINK10.36449494
77PRKCA0.36402491
78JAK10.32661401
79MST40.32384002
80AURKA0.29811910
81PIK3CA0.29504674
82IRAK40.28321431
83MARK30.28317715
84PRKACA0.28258703
85ROCK10.28180693
86PRKCD0.27068553
87SRC0.26893983
88MAPKAPK20.26467919
89TGFBR20.25878090
90PAK10.25389023
91EGFR0.25353338
92OXSR10.24480090
93STK390.23143360
94FGR0.21720323
95SIK20.21223896
96RPS6KB20.21119411
97PRKCB0.19472485
98JAK20.19226509
99PHKG10.18149972
100PHKG20.18149972

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.00677347
2Graft-versus-host disease_Homo sapiens_hsa053323.61328942
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.24794650
4Antigen processing and presentation_Homo sapiens_hsa046123.13851284
5Autoimmune thyroid disease_Homo sapiens_hsa053203.08319167
6Hematopoietic cell lineage_Homo sapiens_hsa046402.98216282
7Allograft rejection_Homo sapiens_hsa053302.97272376
8Proteasome_Homo sapiens_hsa030502.96869627
9T cell receptor signaling pathway_Homo sapiens_hsa046602.67452537
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.51585142
11Phototransduction_Homo sapiens_hsa047442.37105413
12Type I diabetes mellitus_Homo sapiens_hsa049402.23599603
13Oxidative phosphorylation_Homo sapiens_hsa001902.21318910
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.89738141
15Measles_Homo sapiens_hsa051621.82652428
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75005846
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.70689801
18Parkinsons disease_Homo sapiens_hsa050121.66939819
19Shigellosis_Homo sapiens_hsa051311.60636706
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.60304425
21Rheumatoid arthritis_Homo sapiens_hsa053231.58403708
22Malaria_Homo sapiens_hsa051441.52696263
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43798331
24Nitrogen metabolism_Homo sapiens_hsa009101.41935162
25Ribosome_Homo sapiens_hsa030101.39193596
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36133755
27Asthma_Homo sapiens_hsa053101.29439249
28Viral myocarditis_Homo sapiens_hsa054161.27872608
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27191892
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23859141
31Staphylococcus aureus infection_Homo sapiens_hsa051501.12994320
32Alzheimers disease_Homo sapiens_hsa050101.09867718
33Linoleic acid metabolism_Homo sapiens_hsa005911.07118950
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00118876
35Caffeine metabolism_Homo sapiens_hsa002320.97476771
36Salmonella infection_Homo sapiens_hsa051320.94359137
37Olfactory transduction_Homo sapiens_hsa047400.94231677
38Arachidonic acid metabolism_Homo sapiens_hsa005900.92294353
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91788733
40Steroid hormone biosynthesis_Homo sapiens_hsa001400.89238612
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85619558
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84133769
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81307366
44Leishmaniasis_Homo sapiens_hsa051400.78036575
45Chemokine signaling pathway_Homo sapiens_hsa040620.76386299
46Systemic lupus erythematosus_Homo sapiens_hsa053220.72834339
47Herpes simplex infection_Homo sapiens_hsa051680.71947917
48Peroxisome_Homo sapiens_hsa041460.71914463
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70941857
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.68378380
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66597667
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.62936515
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62851751
54Huntingtons disease_Homo sapiens_hsa050160.62394853
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61277736
56Pertussis_Homo sapiens_hsa051330.60661019
57Cardiac muscle contraction_Homo sapiens_hsa042600.58886854
58African trypanosomiasis_Homo sapiens_hsa051430.57797500
59Chemical carcinogenesis_Homo sapiens_hsa052040.57368962
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.55499259
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55349849
62Retinol metabolism_Homo sapiens_hsa008300.54428112
63Homologous recombination_Homo sapiens_hsa034400.54299391
64Tryptophan metabolism_Homo sapiens_hsa003800.52120804
65Osteoclast differentiation_Homo sapiens_hsa043800.51766036
66Platelet activation_Homo sapiens_hsa046110.49428798
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48639669
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47714649
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46350557
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44912145
71Purine metabolism_Homo sapiens_hsa002300.44761965
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40969065
73Mismatch repair_Homo sapiens_hsa034300.40709499
74Legionellosis_Homo sapiens_hsa051340.39835418
75TNF signaling pathway_Homo sapiens_hsa046680.38604236
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38323038
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38171807
78Nucleotide excision repair_Homo sapiens_hsa034200.34634261
79Morphine addiction_Homo sapiens_hsa050320.33434390
80B cell receptor signaling pathway_Homo sapiens_hsa046620.33095802
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32983872
82Butanoate metabolism_Homo sapiens_hsa006500.30446349
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30392426
84Taste transduction_Homo sapiens_hsa047420.29526690
85RNA polymerase_Homo sapiens_hsa030200.29151801
86Serotonergic synapse_Homo sapiens_hsa047260.28123302
87Pyrimidine metabolism_Homo sapiens_hsa002400.26665514
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26517858
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.25334763
90Sulfur metabolism_Homo sapiens_hsa009200.24865261
91Salivary secretion_Homo sapiens_hsa049700.23937672
92Protein export_Homo sapiens_hsa030600.22923951
93Tuberculosis_Homo sapiens_hsa051520.22834973
94DNA replication_Homo sapiens_hsa030300.21660540
95Fanconi anemia pathway_Homo sapiens_hsa034600.21576881
96Apoptosis_Homo sapiens_hsa042100.21078494
97Alcoholism_Homo sapiens_hsa050340.20513660
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.20041166
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19372226
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18246936

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