BIN2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.91751107
2DNA deamination (GO:0045006)7.92801326
3cytidine metabolic process (GO:0046087)7.65922813
4cytidine catabolic process (GO:0006216)7.65922813
5cytidine deamination (GO:0009972)7.65922813
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.90430096
7mast cell activation involved in immune response (GO:0002279)5.05551063
8mast cell degranulation (GO:0043303)5.05551063
9sleep (GO:0030431)4.99608403
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.40578279
11regulation of B cell receptor signaling pathway (GO:0050855)4.26111190
12mast cell activation (GO:0045576)4.21235944
13negative regulation of T cell apoptotic process (GO:0070233)4.20104872
14response to interferon-beta (GO:0035456)4.10593967
15positive regulation of granulocyte differentiation (GO:0030854)3.87867560
16pyrimidine nucleoside catabolic process (GO:0046135)3.86621717
17regulation of T cell mediated cytotoxicity (GO:0001914)3.76823077
18response to gravity (GO:0009629)3.72523040
19CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.71450961
20T-helper cell differentiation (GO:0042093)3.71450961
21positive regulation of T cell mediated cytotoxicity (GO:0001916)3.70550951
22T cell migration (GO:0072678)3.60985534
23leukocyte degranulation (GO:0043299)3.55747116
24tolerance induction (GO:0002507)3.53153102
25positive regulation of alpha-beta T cell proliferation (GO:0046641)3.51586520
26positive thymic T cell selection (GO:0045059)3.50190938
27fusion of sperm to egg plasma membrane (GO:0007342)3.45998740
28negative T cell selection (GO:0043383)3.44298293
29negative thymic T cell selection (GO:0045060)3.41977356
30negative regulation of mast cell activation (GO:0033004)3.40963918
31negative regulation of viral genome replication (GO:0045071)3.35715974
32autophagic vacuole fusion (GO:0000046)3.33109676
33alpha-beta T cell differentiation involved in immune response (GO:0002293)3.31863856
34alpha-beta T cell activation involved in immune response (GO:0002287)3.31863856
35T cell differentiation involved in immune response (GO:0002292)3.31863856
36cellular response to interferon-beta (GO:0035458)3.31180404
37cellular response to interleukin-15 (GO:0071350)3.28986710
38rRNA methylation (GO:0031167)3.24129883
39regulation of leukocyte mediated cytotoxicity (GO:0001910)3.23698172
40positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.17129719
41lymphocyte chemotaxis (GO:0048247)3.15672828
42regulation of T cell apoptotic process (GO:0070232)3.15321179
43Arp2/3 complex-mediated actin nucleation (GO:0034314)3.15262236
44negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.13740561
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.13334205
46negative regulation of cell killing (GO:0031342)3.13334205
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12073849
48lymphocyte migration (GO:0072676)3.11975225
49actin nucleation (GO:0045010)3.11197724
50CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.10989934
51alpha-beta T cell differentiation (GO:0046632)3.10855433
52positive regulation of macrophage differentiation (GO:0045651)3.07208363
53regulation of alpha-beta T cell proliferation (GO:0046640)3.06580676
54regulation of defense response to virus by host (GO:0050691)3.06159009
55natural killer cell activation (GO:0030101)3.05116479
56negative regulation of interleukin-1 beta production (GO:0032691)3.04519157
57regulation of regulatory T cell differentiation (GO:0045589)3.02783481
58regulation of T cell receptor signaling pathway (GO:0050856)3.02696564
59lysosome localization (GO:0032418)3.01854734
60regulation of isotype switching to IgG isotypes (GO:0048302)3.00450754
61positive T cell selection (GO:0043368)2.97654912
62leukotriene biosynthetic process (GO:0019370)2.96614460
63neutrophil activation (GO:0042119)2.95822795
64piRNA metabolic process (GO:0034587)2.95281816
65regulation of cell killing (GO:0031341)2.94860648
66regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.93759705
67CD4-positive, alpha-beta T cell activation (GO:0035710)2.91740408
68arginine metabolic process (GO:0006525)2.91058765
69positive regulation of cell killing (GO:0031343)2.90414451
70regulation of chronic inflammatory response (GO:0002676)2.89896439
71purinergic nucleotide receptor signaling pathway (GO:0035590)2.89782552
72G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.88362513
73negative regulation of stress fiber assembly (GO:0051497)2.88046599
74urea cycle (GO:0000050)2.87331336
75positive regulation of T cell mediated immunity (GO:0002711)2.87135167
76positive regulation of NF-kappaB import into nucleus (GO:0042346)2.86462157
77adenosine metabolic process (GO:0046085)2.86282286
78negative regulation of lymphocyte apoptotic process (GO:0070229)2.83049656
79positive regulation of natural killer cell differentiation (GO:0032825)2.79553245
80positive regulation of mRNA catabolic process (GO:0061014)2.75908056
81positive regulation of T cell cytokine production (GO:0002726)2.74437471
82plasma membrane fusion (GO:0045026)2.74347533
83male meiosis I (GO:0007141)2.71796489
84negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.71536345
85multicellular organism reproduction (GO:0032504)2.71429582
86axoneme assembly (GO:0035082)2.70876275
87alpha-beta T cell activation (GO:0046631)2.70199151
88negative regulation of interleukin-1 production (GO:0032692)2.69151730
89positive regulation of T cell chemotaxis (GO:0010820)2.69035032
90regulation of T cell chemotaxis (GO:0010819)2.69035032
91regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.68876913
92thymic T cell selection (GO:0045061)2.67838402
93regulation of germinal center formation (GO:0002634)2.67217592
94negative regulation of actin filament bundle assembly (GO:0032232)2.66753526
95positive regulation of defense response to virus by host (GO:0002230)2.65972587
96dendritic cell chemotaxis (GO:0002407)2.64838345
97regulation of immunoglobulin secretion (GO:0051023)2.64268913
98positive regulation of B cell differentiation (GO:0045579)2.63972875
99positive regulation of T-helper 1 type immune response (GO:0002827)2.62862894
100regulation of cellular extravasation (GO:0002691)2.62729698

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.61163428
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.94146952
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.34702971
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.30665907
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.24391099
6RUNX_20019798_ChIP-Seq_JUKART_Human3.21190160
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.12717579
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.93180059
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.80735278
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.80190473
11MYB_26560356_Chip-Seq_TH2_Human2.78396936
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.63222931
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.41865397
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28780959
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.24045762
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.16854935
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.13478176
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.11358386
19GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.08394277
20GATA3_27048872_Chip-Seq_THYMUS_Human2.03946718
21GATA3_26560356_Chip-Seq_TH2_Human1.95944552
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85825322
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.80107392
24MYB_26560356_Chip-Seq_TH1_Human1.68580272
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67959588
26EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.63344746
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60040684
28BCL6_27268052_Chip-Seq_Bcells_Human1.59857134
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59208136
30UTX_26944678_Chip-Seq_JUKART_Human1.55788090
31SCL_19346495_ChIP-Seq_HPC-7_Human1.53518082
32TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.53190781
33VDR_23849224_ChIP-Seq_CD4+_Human1.49140958
34VDR_22108803_ChIP-Seq_LS180_Human1.49140677
35EZH2_22144423_ChIP-Seq_EOC_Human1.48138992
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46103750
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46061440
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44051718
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43474266
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42987188
41MAF_26560356_Chip-Seq_TH1_Human1.41687614
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38891754
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.37967437
44RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.35316655
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.31266229
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30654077
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29067080
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.29067080
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28659097
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.27777646
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.26869230
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26407368
53ZNF274_21170338_ChIP-Seq_K562_Hela1.25510646
54SPI1_23547873_ChIP-Seq_NB4_Human1.23767620
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.23235452
56RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.22659372
57NANOG_20526341_ChIP-Seq_ESCs_Human1.22267982
58TP53_22573176_ChIP-Seq_HFKS_Human1.21687817
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.21517760
60MYC_19829295_ChIP-Seq_ESCs_Human1.20731902
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19825687
62CBP_20019798_ChIP-Seq_JUKART_Human1.18476762
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18476762
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16192512
65ER_23166858_ChIP-Seq_MCF-7_Human1.14452496
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.14355389
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12920766
68HOXB7_26014856_ChIP-Seq_BT474_Human1.12836583
69NANOG_19829295_ChIP-Seq_ESCs_Human1.12173632
70SOX2_19829295_ChIP-Seq_ESCs_Human1.12173632
71MAF_26560356_Chip-Seq_TH2_Human1.11719321
72CTCF_20526341_ChIP-Seq_ESCs_Human1.10436314
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09961711
74ERA_21632823_ChIP-Seq_H3396_Human1.08295185
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07041443
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06938388
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06322955
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.05827207
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04530768
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04240741
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02459349
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02454810
83FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02304527
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99013767
85BCOR_27268052_Chip-Seq_Bcells_Human0.98175244
86GATA2_21666600_ChIP-Seq_HMVEC_Human0.97868671
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97556066
88SOX2_22085726_ChIP-Seq_NPCs_Mouse0.97246917
89IRF1_19129219_ChIP-ChIP_H3396_Human0.96427624
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95967478
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93480604
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93334342
93CRX_20693478_ChIP-Seq_RETINA_Mouse0.93231954
94P300_27268052_Chip-Seq_Bcells_Human0.91138029
95HTT_18923047_ChIP-ChIP_STHdh_Human0.91044357
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90664888
97E2F1_20622854_ChIP-Seq_HELA_Human0.90119243
98AR_20517297_ChIP-Seq_VCAP_Human0.90003494
99SALL4_22934838_ChIP-ChIP_CD34+_Human0.89374825
100GBX2_23144817_ChIP-Seq_PC3_Human0.88793932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.61489361
2MP0005671_abnormal_response_to3.91181920
3MP0003763_abnormal_thymus_physiology3.77332364
4MP0005000_abnormal_immune_tolerance2.87400633
5MP0005464_abnormal_platelet_physiology2.86719320
6MP0003436_decreased_susceptibility_to2.76022484
7MP0000685_abnormal_immune_system2.69674658
8MP0002933_joint_inflammation2.46302649
9MP0001835_abnormal_antigen_presentation2.35391963
10MP0009785_altered_susceptibility_to2.34519272
11MP0001800_abnormal_humoral_immune2.33476763
12MP0002723_abnormal_immune_serum2.31161910
13MP0002166_altered_tumor_susceptibility2.29579452
14MP0003646_muscle_fatigue2.26295156
15MP0002405_respiratory_system_inflammati2.13161220
16MP0002148_abnormal_hypersensitivity_rea2.12397792
17MP0002876_abnormal_thyroid_physiology2.10579208
18MP0001873_stomach_inflammation2.08890227
19MP0000465_gastrointestinal_hemorrhage2.03192451
20MP0002420_abnormal_adaptive_immunity2.02811757
21MP0001819_abnormal_immune_cell1.99770097
22MP0001501_abnormal_sleep_pattern1.97970874
23MP0002452_abnormal_antigen_presenting1.95899086
24MP0006072_abnormal_retinal_apoptosis1.95896893
25MP0005025_abnormal_response_to1.94634343
26MP0005387_immune_system_phenotype1.94228918
27MP0001790_abnormal_immune_system1.94228918
28MP0002006_tumorigenesis1.86218607
29MP0008872_abnormal_physiological_respon1.82837620
30MP0000858_altered_metastatic_potential1.77665079
31MP0005410_abnormal_fertilization1.76935961
32MP0002009_preneoplasia1.74623244
33MP0004147_increased_porphyrin_level1.69391425
34MP0009333_abnormal_splenocyte_physiolog1.68683920
35MP0004947_skin_inflammation1.67026071
36MP0002736_abnormal_nociception_after1.66365128
37MP0001533_abnormal_skeleton_physiology1.66176085
38MP0002398_abnormal_bone_marrow1.65378989
39MP0003866_abnormal_defecation1.63775710
40MP0002419_abnormal_innate_immunity1.60943397
41MP0002254_reproductive_system_inflammat1.53329387
42MP0000716_abnormal_immune_system1.52874918
43MP0005083_abnormal_biliary_tract1.51717754
44MP0002722_abnormal_immune_system1.45822308
45MP0002909_abnormal_adrenal_gland1.44564151
46MP0001919_abnormal_reproductive_system1.43486723
47MP0000689_abnormal_spleen_morphology1.42304957
48MP0001845_abnormal_inflammatory_respons1.38439260
49MP0000703_abnormal_thymus_morphology1.38235025
50MP0000569_abnormal_digit_pigmentation1.36355849
51MP0005646_abnormal_pituitary_gland1.34022091
52MP0002102_abnormal_ear_morphology1.29465171
53MP0010155_abnormal_intestine_physiology1.28079477
54MP0000015_abnormal_ear_pigmentation1.26255608
55MP0002429_abnormal_blood_cell1.20565115
56MP0005075_abnormal_melanosome_morpholog1.19455207
57MP0001765_abnormal_ion_homeostasis1.09640110
58MP0003045_fibrosis1.09135767
59MP0001853_heart_inflammation1.08769231
60MP0003656_abnormal_erythrocyte_physiolo1.07428594
61MP0002822_catalepsy1.07017626
62MP0001542_abnormal_bone_strength1.06188081
63MP0004381_abnormal_hair_follicle1.03612134
64MP0001879_abnormal_lymphatic_vessel1.03284675
65MP0008875_abnormal_xenobiotic_pharmacok1.00917368
66MP0009764_decreased_sensitivity_to1.00897752
67MP0005389_reproductive_system_phenotype0.99962326
68MP0004885_abnormal_endolymph0.99785076
69MP0000230_abnormal_systemic_arterial0.99673756
70MP0003448_altered_tumor_morphology0.98249307
71MP0005551_abnormal_eye_electrophysiolog0.97201313
72MP0001968_abnormal_touch/_nociception0.95717443
73MP0005166_decreased_susceptibility_to0.91660311
74MP0000604_amyloidosis0.91623548
75MP0005390_skeleton_phenotype0.91277648
76MP0003638_abnormal_response/metabolism_0.86633597
77MP0001243_abnormal_dermal_layer0.84828182
78MP0005084_abnormal_gallbladder_morpholo0.84175391
79MP0003329_amyloid_beta_deposits0.80640471
80MP0003195_calcinosis0.79568165
81MP0000383_abnormal_hair_follicle0.79567094
82MP0001851_eye_inflammation0.79399099
83MP0003075_altered_response_to0.78046811
84MP0003878_abnormal_ear_physiology0.77837271
85MP0005377_hearing/vestibular/ear_phenot0.77837271
86MP0008469_abnormal_protein_level0.77784712
87MP0003786_premature_aging0.77761643
88MP0005085_abnormal_gallbladder_physiolo0.77720648
89MP0006082_CNS_inflammation0.74972274
90MP0002277_abnormal_respiratory_mucosa0.73867523
91MP0000249_abnormal_blood_vessel0.73051113
92MP0004145_abnormal_muscle_electrophysio0.72575785
93MP0005253_abnormal_eye_physiology0.70289605
94MP0005409_darkened_coat_color0.69522797
95MP0005174_abnormal_tail_pigmentation0.67199073
96MP0008995_early_reproductive_senescence0.67198608
97MP0002136_abnormal_kidney_physiology0.64205525
98MP0003795_abnormal_bone_structure0.63494858
99MP0006054_spinal_hemorrhage0.63170540
100MP0009763_increased_sensitivity_to0.63071564

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.37806453
2Elevated erythrocyte sedimentation rate (HP:0003565)5.96216664
3IgG deficiency (HP:0004315)5.85226449
4Aplastic anemia (HP:0001915)4.64051566
5Confusion (HP:0001289)4.00205735
6Rib fusion (HP:0000902)3.79763355
7IgM deficiency (HP:0002850)3.52176079
8Severe combined immunodeficiency (HP:0004430)3.45561450
9Stomach cancer (HP:0012126)3.29018958
10Abnormality of alanine metabolism (HP:0010916)3.19133513
11Hyperalaninemia (HP:0003348)3.19133513
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.19133513
133-Methylglutaconic aciduria (HP:0003535)3.12492269
14Increased IgM level (HP:0003496)2.96590325
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.90104736
16T lymphocytopenia (HP:0005403)2.89785335
17Eczematoid dermatitis (HP:0000976)2.86244218
18Alkalosis (HP:0001948)2.79494653
19Congenital stationary night blindness (HP:0007642)2.77217469
20Congenital, generalized hypertrichosis (HP:0004540)2.76279457
21Abnormality of T cells (HP:0002843)2.74016720
22Hypokalemic alkalosis (HP:0001949)2.73472802
23Prolonged bleeding time (HP:0003010)2.66476818
24Prostate neoplasm (HP:0100787)2.65521406
25Abnormality of T cell physiology (HP:0011840)2.60153345
26Abnormality of T cell number (HP:0011839)2.55318362
27Combined immunodeficiency (HP:0005387)2.55064080
28Abnormality of the prostate (HP:0008775)2.53682501
29Abnormal spermatogenesis (HP:0008669)2.52758452
30Cerebral palsy (HP:0100021)2.46650974
31Joint swelling (HP:0001386)2.45663045
32Severe visual impairment (HP:0001141)2.44409178
33Metabolic alkalosis (HP:0200114)2.41367655
34Polyuria (HP:0000103)2.40644496
35Hypoplasia of the fovea (HP:0007750)2.36207090
36Aplasia/Hypoplasia of the fovea (HP:0008060)2.36207090
37Pancytopenia (HP:0001876)2.35812919
38Anomalous pulmonary venous return (HP:0010772)2.35112660
39Polydipsia (HP:0001959)2.32047121
40Abnormal drinking behavior (HP:0030082)2.32047121
41Diplopia (HP:0000651)2.26957057
42Abnormality of binocular vision (HP:0011514)2.26957057
43Erythroderma (HP:0001019)2.24695517
44Hypoplasia of the thymus (HP:0000778)2.21888213
45Abnormality of the phalanges of the 2nd finger (HP:0009541)2.20379170
46Cutaneous melanoma (HP:0012056)2.20348837
47Hypergammaglobulinemia (HP:0010702)2.18893206
48Long clavicles (HP:0000890)2.17384678
49Abnormality of dental color (HP:0011073)2.17143059
50Hypoplasia of the pons (HP:0012110)2.14023822
51Attenuation of retinal blood vessels (HP:0007843)2.13100285
52Pustule (HP:0200039)2.13035074
53Type II lissencephaly (HP:0007260)2.10150914
54Conical tooth (HP:0000698)2.07938483
55Hypomagnesemia (HP:0002917)2.06317310
56Pulmonary fibrosis (HP:0002206)2.04771250
57Abnormal urine output (HP:0012590)2.04292095
58Hepatocellular necrosis (HP:0001404)2.03919758
59Keratoconjunctivitis (HP:0001096)2.03819066
60Abnormality of the pulmonary veins (HP:0011718)2.03695272
61Acanthocytosis (HP:0001927)2.03044886
62Abnormality of the pons (HP:0007361)2.01826288
63Oligomenorrhea (HP:0000876)2.00192145
64Epistaxis (HP:0000421)1.98938629
65Albinism (HP:0001022)1.96658365
66Abnormality of eosinophils (HP:0001879)1.96491044
67Metaphyseal dysplasia (HP:0100255)1.94941357
68Abnormality of the fovea (HP:0000493)1.91885647
69Episodic fever (HP:0001954)1.91693074
70Chronic diarrhea (HP:0002028)1.90711855
71Growth hormone excess (HP:0000845)1.88835659
72Gastrointestinal stroma tumor (HP:0100723)1.88817638
73Increased IgE level (HP:0003212)1.88330868
74B lymphocytopenia (HP:0010976)1.87699892
75Tetany (HP:0001281)1.86083138
76Lymphoma (HP:0002665)1.85578761
77Lymphopenia (HP:0001888)1.85213602
78Absent thumb (HP:0009777)1.84208873
79Type I transferrin isoform profile (HP:0003642)1.83266790
80Fused cervical vertebrae (HP:0002949)1.82311619
81Decreased central vision (HP:0007663)1.80928377
82Absent/shortened dynein arms (HP:0200106)1.79338179
83Dynein arm defect of respiratory motile cilia (HP:0012255)1.79338179
84Abnormality of macrophages (HP:0004311)1.78681742
85Recurrent bronchitis (HP:0002837)1.78347784
86Abolished electroretinogram (ERG) (HP:0000550)1.78196921
87Leukocytosis (HP:0001974)1.78061558
88Molar tooth sign on MRI (HP:0002419)1.76755433
89Abnormality of midbrain morphology (HP:0002418)1.76755433
90Abnormality of the renal cortex (HP:0011035)1.75983309
91Myositis (HP:0100614)1.75336041
92Male infertility (HP:0003251)1.74314927
93Brittle hair (HP:0002299)1.70770424
94Abnormality of renal excretion (HP:0011036)1.70287497
95Palpebral edema (HP:0100540)1.70205190
96Gastrointestinal infarctions (HP:0005244)1.69450963
97Hepatic necrosis (HP:0002605)1.69231288
98Respiratory distress (HP:0002098)1.67337785
99Abnormality of B cell number (HP:0010975)1.67331949
100Abnormal number of erythroid precursors (HP:0012131)1.67249220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.14728162
2TXK3.57705698
3ZAP703.46946714
4TESK23.30514097
5ZAK3.20207192
6GRK62.98537689
7KDR2.85110230
8EPHA32.40100192
9MST42.37977789
10MAP4K12.34780214
11MAP2K22.16780433
12FES2.16199962
13TESK12.09983038
14TLK11.95092782
15NME11.83062808
16ITK1.80697593
17SYK1.80457577
18MAPKAPK31.64576680
19MAP4K21.60975296
20LIMK11.60258797
21IKBKE1.57285309
22MAP3K141.56942448
23IKBKB1.56856802
24PINK11.50476455
25BCKDK1.46688983
26CAMKK21.42996191
27DAPK11.37713510
28WNK41.35585217
29ACVR1B1.31840119
30RPS6KA41.29368784
31NUAK11.26019205
32MUSK1.25901307
33TBK11.22732447
34BTK1.22384290
35MAP3K111.19092254
36TEC1.18395897
37EPHB11.17970145
38CCNB11.15012138
39MAP3K121.14409930
40STK391.12268408
41STK38L1.03352583
42OXSR11.02569392
43JAK10.99267846
44PIM10.98963378
45VRK20.95782991
46BLK0.95736585
47CSK0.95507236
48DYRK30.92594630
49PLK40.90752717
50MELK0.89403077
51RIPK40.89100557
52DAPK20.89046642
53INSRR0.87975473
54ADRBK20.87788007
55LCK0.85552021
56LYN0.83868220
57FGR0.80455778
58CSF1R0.78065789
59PHKG20.75822877
60PHKG10.75822877
61TIE10.75590333
62HCK0.72482567
63PIK3CG0.71728884
64NLK0.69639018
65IRAK40.68337733
66IRAK10.68091286
67RPS6KA50.64735591
68JAK30.62743549
69MYLK0.61678409
70VRK10.61432432
71PLK20.60767699
72TNK20.56901901
73HIPK20.55615658
74ADRBK10.53916726
75GRK10.52578467
76MAPK110.52463875
77MAPK150.50072048
78FER0.48781067
79MAPKAPK20.47852590
80RPS6KA60.44706539
81PTK2B0.44361138
82PRKCQ0.42474807
83KIT0.41602547
84BMX0.41505017
85MAP3K50.41230898
86PDGFRB0.39527998
87GRK50.37301975
88MAPK30.37105971
89TRPM70.35031187
90MAPK70.34979580
91RET0.34805204
92RPS6KA20.33069483
93LRRK20.29986479
94DYRK20.29473575
95INSR0.28481474
96FGFR40.27640194
97PRKCI0.27029967
98IGF1R0.26864288
99ABL10.25694519
100MAPK40.24434386

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.31513213
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.98943219
3Graft-versus-host disease_Homo sapiens_hsa053322.65276980
4Allograft rejection_Homo sapiens_hsa053302.44564628
5Autoimmune thyroid disease_Homo sapiens_hsa053202.36835629
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.36685918
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.33977745
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.13998760
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.13885260
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.08774842
11T cell receptor signaling pathway_Homo sapiens_hsa046601.95125019
12Proteasome_Homo sapiens_hsa030501.87546855
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87110215
14Antigen processing and presentation_Homo sapiens_hsa046121.80353473
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72782588
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.72503325
17Hematopoietic cell lineage_Homo sapiens_hsa046401.72466859
18Linoleic acid metabolism_Homo sapiens_hsa005911.70487243
19Nitrogen metabolism_Homo sapiens_hsa009101.70088585
20Asthma_Homo sapiens_hsa053101.62754112
21Sulfur relay system_Homo sapiens_hsa041221.52684600
22Measles_Homo sapiens_hsa051621.45802950
23Type I diabetes mellitus_Homo sapiens_hsa049401.45199445
24Homologous recombination_Homo sapiens_hsa034401.42997837
25Shigellosis_Homo sapiens_hsa051311.41752655
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39270540
27Phototransduction_Homo sapiens_hsa047441.39116881
28Malaria_Homo sapiens_hsa051441.37022277
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.33045094
30Fanconi anemia pathway_Homo sapiens_hsa034601.32820051
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32182177
32Oxidative phosphorylation_Homo sapiens_hsa001901.31826983
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30585502
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30418246
35Olfactory transduction_Homo sapiens_hsa047401.30120524
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28213111
37Viral myocarditis_Homo sapiens_hsa054161.24748389
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16011121
39Herpes simplex infection_Homo sapiens_hsa051681.15971232
40Parkinsons disease_Homo sapiens_hsa050121.15892049
41Selenocompound metabolism_Homo sapiens_hsa004501.13461998
42Rheumatoid arthritis_Homo sapiens_hsa053231.08782313
43Regulation of autophagy_Homo sapiens_hsa041401.07980724
44Arachidonic acid metabolism_Homo sapiens_hsa005901.06983594
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06757659
46Basal transcription factors_Homo sapiens_hsa030221.05908586
47Arginine biosynthesis_Homo sapiens_hsa002201.00017178
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98013215
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94480695
50Chemical carcinogenesis_Homo sapiens_hsa052040.94098431
51Legionellosis_Homo sapiens_hsa051340.93824329
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93395702
53TNF signaling pathway_Homo sapiens_hsa046680.91921124
54Protein export_Homo sapiens_hsa030600.90326276
55Leishmaniasis_Homo sapiens_hsa051400.90032274
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89336254
57Tryptophan metabolism_Homo sapiens_hsa003800.88850438
58Fatty acid biosynthesis_Homo sapiens_hsa000610.84506258
59Glycerolipid metabolism_Homo sapiens_hsa005610.81157698
60Sulfur metabolism_Homo sapiens_hsa009200.80991342
61Platelet activation_Homo sapiens_hsa046110.80938637
62Taste transduction_Homo sapiens_hsa047420.79817293
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79669344
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79176511
65Huntingtons disease_Homo sapiens_hsa050160.76209893
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75892856
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71512440
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69897384
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67149586
70Alzheimers disease_Homo sapiens_hsa050100.66752452
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.63687323
72RNA degradation_Homo sapiens_hsa030180.60246160
73Fat digestion and absorption_Homo sapiens_hsa049750.59671810
74RNA polymerase_Homo sapiens_hsa030200.59504031
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57512944
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.56473838
77Pertussis_Homo sapiens_hsa051330.56421282
78Apoptosis_Homo sapiens_hsa042100.53018035
79Caffeine metabolism_Homo sapiens_hsa002320.52638062
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52589049
81Nicotine addiction_Homo sapiens_hsa050330.51774979
82Staphylococcus aureus infection_Homo sapiens_hsa051500.50209683
83B cell receptor signaling pathway_Homo sapiens_hsa046620.50122750
84Renin secretion_Homo sapiens_hsa049240.49950014
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.48862248
86Salivary secretion_Homo sapiens_hsa049700.48297254
87Purine metabolism_Homo sapiens_hsa002300.48132517
88Morphine addiction_Homo sapiens_hsa050320.47154063
89Ether lipid metabolism_Homo sapiens_hsa005650.46982785
90Ovarian steroidogenesis_Homo sapiens_hsa049130.42572905
91Cardiac muscle contraction_Homo sapiens_hsa042600.41300124
92Calcium signaling pathway_Homo sapiens_hsa040200.40776591
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.40662910
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38465348
95Amphetamine addiction_Homo sapiens_hsa050310.37238621
96Collecting duct acid secretion_Homo sapiens_hsa049660.37005608
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35439525
98African trypanosomiasis_Homo sapiens_hsa051430.34855535
99Serotonergic synapse_Homo sapiens_hsa047260.33628720
100Pyrimidine metabolism_Homo sapiens_hsa002400.32431558

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