BIRC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.57395220
2protein localization to kinetochore (GO:0034501)5.35367187
3kinetochore organization (GO:0051383)5.16098265
4CENP-A containing nucleosome assembly (GO:0034080)4.97932171
5protein localization to chromosome, centromeric region (GO:0071459)4.94705885
6kinetochore assembly (GO:0051382)4.86882803
7metaphase plate congression (GO:0051310)4.84485012
8chromatin remodeling at centromere (GO:0031055)4.82645755
9mitotic sister chromatid segregation (GO:0000070)4.82034095
10attachment of spindle microtubules to kinetochore (GO:0008608)4.66724769
11DNA strand elongation involved in DNA replication (GO:0006271)4.57039224
12DNA ligation (GO:0006266)4.53085645
13telomere maintenance via semi-conservative replication (GO:0032201)4.45967031
14mitotic chromosome condensation (GO:0007076)4.44391440
15establishment of integrated proviral latency (GO:0075713)4.40667714
16DNA replication-independent nucleosome assembly (GO:0006336)4.39471521
17DNA replication-independent nucleosome organization (GO:0034724)4.39471521
18DNA replication checkpoint (GO:0000076)4.37960115
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.37934409
20DNA strand elongation (GO:0022616)4.34498782
21sister chromatid segregation (GO:0000819)4.33705468
22DNA replication initiation (GO:0006270)4.30145768
23regulation of spindle organization (GO:0090224)4.25136815
24* establishment of chromosome localization (GO:0051303)4.22517591
25telomere maintenance via recombination (GO:0000722)4.12934338
26histone exchange (GO:0043486)4.12904203
27DNA topological change (GO:0006265)4.03591971
28mitotic recombination (GO:0006312)4.03080225
29mitotic nuclear envelope disassembly (GO:0007077)3.97075519
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.92927270
31meiotic chromosome segregation (GO:0045132)3.91786485
32DNA replication-dependent nucleosome organization (GO:0034723)3.83941384
33DNA replication-dependent nucleosome assembly (GO:0006335)3.83941384
34nuclear pore complex assembly (GO:0051292)3.83579649
35DNA unwinding involved in DNA replication (GO:0006268)3.76275800
36* spindle checkpoint (GO:0031577)3.73566065
37telomere maintenance via telomere lengthening (GO:0010833)3.71487627
38regulation of chromosome segregation (GO:0051983)3.71484827
39negative regulation of chromosome segregation (GO:0051985)3.69462001
40negative regulation of mitotic sister chromatid segregation (GO:0033048)3.69093442
41negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.69093442
42negative regulation of sister chromatid segregation (GO:0033046)3.69093442
43negative regulation of mitotic sister chromatid separation (GO:2000816)3.69093442
44spindle assembly checkpoint (GO:0071173)3.67820404
45ribosomal small subunit assembly (GO:0000028)3.65019848
46membrane disassembly (GO:0030397)3.64502321
47nuclear envelope disassembly (GO:0051081)3.64502321
48maturation of SSU-rRNA (GO:0030490)3.64057638
49negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.62769356
50mitotic spindle assembly checkpoint (GO:0007094)3.60066398
51protein localization to chromosome (GO:0034502)3.59351283
52regulation of mitotic spindle organization (GO:0060236)3.58841660
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.58650753
54DNA deamination (GO:0045006)3.57144815
55mitotic spindle checkpoint (GO:0071174)3.55685455
56regulation of mitotic metaphase/anaphase transition (GO:0030071)3.55152725
57protein K6-linked ubiquitination (GO:0085020)3.55070159
58positive regulation of chromosome segregation (GO:0051984)3.54857960
59* chromosome segregation (GO:0007059)3.52367453
60regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.50582766
61mitotic sister chromatid cohesion (GO:0007064)3.46558200
62nucleotide-excision repair, DNA gap filling (GO:0006297)3.46211568
63nucleobase biosynthetic process (GO:0046112)3.40760543
64regulation of sister chromatid segregation (GO:0033045)3.39721591
65regulation of mitotic sister chromatid separation (GO:0010965)3.39721591
66regulation of mitotic sister chromatid segregation (GO:0033047)3.39721591
67establishment of viral latency (GO:0019043)3.37846978
68regulation of centriole replication (GO:0046599)3.37738262
69formation of translation preinitiation complex (GO:0001731)3.35903586
70regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.34238176
71double-strand break repair via nonhomologous end joining (GO:0006303)3.30644307
72non-recombinational repair (GO:0000726)3.30644307
73regulation of sister chromatid cohesion (GO:0007063)3.30172988
74ventricular cardiac muscle cell development (GO:0055015)3.29717545
75regulation of double-strand break repair via homologous recombination (GO:0010569)3.28177143
76chromatin assembly or disassembly (GO:0006333)3.27904499
77proteasome assembly (GO:0043248)3.27293046
78ribosomal large subunit biogenesis (GO:0042273)3.27145735
79replication fork processing (GO:0031297)3.25198841
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24739019
81regulation of centrosome cycle (GO:0046605)3.24665427
82ribosome assembly (GO:0042255)3.24448453
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.22584325
84purine nucleobase biosynthetic process (GO:0009113)3.22226581
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.20203355
86DNA packaging (GO:0006323)3.20177702
87microtubule depolymerization (GO:0007019)3.19047360
88ATP-dependent chromatin remodeling (GO:0043044)3.18789450
89spliceosomal snRNP assembly (GO:0000387)3.17032180
90viral transcription (GO:0019083)3.15227907
91transcription-coupled nucleotide-excision repair (GO:0006283)3.15099321
92IMP biosynthetic process (GO:0006188)3.14729548
93rRNA modification (GO:0000154)3.14121131
94translational termination (GO:0006415)3.13557773
95positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.13000579
96positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.13000579
97positive regulation of mitotic sister chromatid separation (GO:1901970)3.13000579
98nuclear pore organization (GO:0006999)3.10940900
99* mitotic cell cycle (GO:0000278)3.10079806
100ribosomal small subunit biogenesis (GO:0042274)3.08419672
101ribonucleoprotein complex biogenesis (GO:0022613)3.07312248
102ribosome biogenesis (GO:0042254)3.04859660
103positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04753544
104negative regulation of mitosis (GO:0045839)3.01228176
105regulation of ubiquitin-protein transferase activity (GO:0051438)3.01113950
106G1/S transition of mitotic cell cycle (GO:0000082)3.00851945
107cell cycle G1/S phase transition (GO:0044843)3.00851945
108chromosome condensation (GO:0030261)3.00272233
109DNA strand renaturation (GO:0000733)3.00110792
110translational initiation (GO:0006413)2.98354576
111rRNA processing (GO:0006364)2.97215925
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94819321
113negative regulation of ligase activity (GO:0051352)2.94819321
114telomere maintenance (GO:0000723)2.94125311
115telomere organization (GO:0032200)2.93891732
116maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93537200
117mismatch repair (GO:0006298)2.92980042
118positive regulation of ligase activity (GO:0051351)2.92050483
119negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.91177331
120regulation of ligase activity (GO:0051340)2.90480487
121regulation of nuclear cell cycle DNA replication (GO:0033262)2.90168715

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.90431679
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.12361166
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.29680298
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.12080139
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.07948876
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.53967503
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.40259334
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.00341052
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83726568
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.82994402
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.75941036
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74015482
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.72773247
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72573035
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71937736
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70069967
17AR_21909140_ChIP-Seq_LNCAP_Human2.60836531
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37302813
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32570162
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30400556
21* XRN2_22483619_ChIP-Seq_HELA_Human2.27952837
22VDR_23849224_ChIP-Seq_CD4+_Human2.17377705
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17205008
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12798418
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.12078206
26DCP1A_22483619_ChIP-Seq_HELA_Human2.00670633
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97438424
28FOXP3_21729870_ChIP-Seq_TREG_Human1.94272421
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93304246
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89818902
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88254462
32* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83611433
33TTF2_22483619_ChIP-Seq_HELA_Human1.82729004
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81448991
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81215420
36GABP_19822575_ChIP-Seq_HepG2_Human1.79128083
37* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71283291
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69451400
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69401866
40ELK1_19687146_ChIP-ChIP_HELA_Human1.65114733
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63313177
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60782628
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60285657
44CIITA_25753668_ChIP-Seq_RAJI_Human1.53249075
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53158060
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51738496
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.50188892
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45991540
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.45717826
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42598384
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.40709385
52KDM5A_27292631_Chip-Seq_BREAST_Human1.39621502
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38235020
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37315261
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.34162088
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32078513
57* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31192061
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29864626
59* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25657282
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22798239
61MYC_22102868_ChIP-Seq_BL_Human1.13197141
62* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12604418
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12105417
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12060713
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10322706
66MYC_18940864_ChIP-ChIP_HL60_Human1.10303067
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10136870
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10116212
69* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09976376
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09705865
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08461183
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08020220
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06300864
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03111696
75* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02390538
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.01912286
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01459243
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01119649
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00603582
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98269854
81SOX2_16153702_ChIP-ChIP_HESCs_Human0.96855896
82TFEB_21752829_ChIP-Seq_HELA_Human0.94321606
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93829978
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89655860
85* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89558851
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88837901
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88420999
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88101121
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87357570
90NANOG_21062744_ChIP-ChIP_HESCs_Human0.86473564
91RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86393974
92ELK1_22589737_ChIP-Seq_MCF10A_Human0.83410585
93SPI1_23547873_ChIP-Seq_NB4_Human0.81186234
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80068202
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76707642
96EWS_26573619_Chip-Seq_HEK293_Human0.75048151
97* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74811107
98VDR_21846776_ChIP-Seq_THP-1_Human0.74546812
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.74047935
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.73793991
101* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73551764
102TCF3_18692474_ChIP-Seq_MEFs_Mouse0.72253904
103SOX17_20123909_ChIP-Seq_XEN_Mouse0.71814943
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.71590894
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71526328
106NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.70838164
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70793914
108ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70682723
109SALL1_21062744_ChIP-ChIP_HESCs_Human0.69632693
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.69577548
111TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.69081399
112OCT4_18692474_ChIP-Seq_MEFs_Mouse0.67959902
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.66578472
114CHD1_26751641_Chip-Seq_LNCaP_Human0.65889479
115* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.65705646

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003693_abnormal_embryo_hatching5.87867746
2* MP0003111_abnormal_nucleus_morphology5.17840446
3MP0010094_abnormal_chromosome_stability4.98579102
4* MP0004957_abnormal_blastocyst_morpholog4.56803988
5* MP0003077_abnormal_cell_cycle4.46983027
6MP0008057_abnormal_DNA_replication3.79303201
7MP0008058_abnormal_DNA_repair3.36853573
8MP0008007_abnormal_cellular_replicative3.03115112
9MP0008932_abnormal_embryonic_tissue3.00796266
10MP0003718_maternal_effect2.52642654
11MP0003123_paternal_imprinting2.43613657
12MP0003136_yellow_coat_color2.33863487
13MP0001730_embryonic_growth_arrest2.30275939
14MP0000372_irregular_coat_pigmentation2.29715522
15MP0000350_abnormal_cell_proliferation2.19490255
16MP0002396_abnormal_hematopoietic_system2.07203369
17MP0008877_abnormal_DNA_methylation2.06250217
18MP0005171_absent_coat_pigmentation1.98723123
19MP0003786_premature_aging1.94503965
20MP0005380_embryogenesis_phenotype1.75177593
21MP0001672_abnormal_embryogenesis/_devel1.75177593
22MP0001697_abnormal_embryo_size1.73584208
23MP0000490_abnormal_crypts_of1.70798562
24MP0010307_abnormal_tumor_latency1.65263316
25MP0010030_abnormal_orbit_morphology1.57008186
26* MP0002085_abnormal_embryonic_tissue1.53627797
27* MP0002080_prenatal_lethality1.52388743
28MP0003984_embryonic_growth_retardation1.49476250
29MP0003315_abnormal_perineum_morphology1.49121966
30MP0002088_abnormal_embryonic_growth/wei1.45713644
31MP0002019_abnormal_tumor_incidence1.43606646
32* MP0000313_abnormal_cell_death1.43300875
33MP0010352_gastrointestinal_tract_polyps1.41679290
34MP0002210_abnormal_sex_determination1.40224339
35MP0006292_abnormal_olfactory_placode1.38793282
36MP0002877_abnormal_melanocyte_morpholog1.34992641
37MP0002084_abnormal_developmental_patter1.29226582
38* MP0002086_abnormal_extraembryonic_tissu1.27509210
39MP0004808_abnormal_hematopoietic_stem1.25597429
40MP0003121_genomic_imprinting1.25265588
41MP0002102_abnormal_ear_morphology1.24537470
42MP0001929_abnormal_gametogenesis1.19243536
43MP0003567_abnormal_fetal_cardiomyocyte1.17965736
44MP0006035_abnormal_mitochondrial_morpho1.17926553
45MP0001145_abnormal_male_reproductive1.17672192
46MP0002697_abnormal_eye_size1.17351724
47MP0009333_abnormal_splenocyte_physiolog1.17176961
48MP0001346_abnormal_lacrimal_gland1.16714530
49MP0001119_abnormal_female_reproductive1.13959865
50MP0004197_abnormal_fetal_growth/weight/1.10898532
51MP0000653_abnormal_sex_gland1.09569250
52MP0001529_abnormal_vocalization1.06926387
53MP0001545_abnormal_hematopoietic_system1.05851129
54MP0005397_hematopoietic_system_phenotyp1.05851129
55MP0003937_abnormal_limbs/digits/tail_de1.03164361
56MP0001293_anophthalmia1.02555127
57MP0005076_abnormal_cell_differentiation1.01656992
58MP0000015_abnormal_ear_pigmentation1.00010761
59MP0002233_abnormal_nose_morphology0.94901180
60MP0003186_abnormal_redox_activity0.94644131
61MP0000566_synostosis0.94315286
62* MP0000703_abnormal_thymus_morphology0.93752821
63MP0005389_reproductive_system_phenotype0.93334554
64MP0002234_abnormal_pharynx_morphology0.93117601
65MP0003890_abnormal_embryonic-extraembry0.91912512
66MP0009053_abnormal_anal_canal0.90555071
67MP0008789_abnormal_olfactory_epithelium0.89631435
68MP0003941_abnormal_skin_development0.89370112
69MP0003763_abnormal_thymus_physiology0.89344832
70MP0002160_abnormal_reproductive_system0.89061415
71MP0002132_abnormal_respiratory_system0.88252743
72MP0000858_altered_metastatic_potential0.87680667
73* MP0002398_abnormal_bone_marrow0.87100859
74* MP0002722_abnormal_immune_system0.84928131
75MP0003755_abnormal_palate_morphology0.82545451
76MP0000689_abnormal_spleen_morphology0.81817042
77MP0006054_spinal_hemorrhage0.81747770
78MP0002111_abnormal_tail_morphology0.81082861
79MP0001919_abnormal_reproductive_system0.80830105
80MP0003806_abnormal_nucleotide_metabolis0.80418137
81* MP0006036_abnormal_mitochondrial_physio0.78373724
82MP0005174_abnormal_tail_pigmentation0.77934567
83MP0005384_cellular_phenotype0.77875604
84MP0003861_abnormal_nervous_system0.76624765
85MP0000358_abnormal_cell_content/0.76618821
86MP0003950_abnormal_plasma_membrane0.75828239
87MP0005621_abnormal_cell_physiology0.75215650
88MP0005395_other_phenotype0.75214932
89MP0003119_abnormal_digestive_system0.75020754
90MP0003699_abnormal_female_reproductive0.75011754
91MP0002653_abnormal_ependyma_morphology0.72567120
92MP0004233_abnormal_muscle_weight0.70389021
93MP0000647_abnormal_sebaceous_gland0.68827433
94* MP0002429_abnormal_blood_cell0.67673132
95MP0009703_decreased_birth_body0.67517275
96MP0005623_abnormal_meninges_morphology0.66988629
97MP0001324_abnormal_eye_pigmentation0.66817493
98MP0001286_abnormal_eye_development0.65879143
99MP0009672_abnormal_birth_weight0.65575654
100MP0005075_abnormal_melanosome_morpholog0.65292882
101MP0003943_abnormal_hepatobiliary_system0.64496951
102MP0005391_vision/eye_phenotype0.64354933
103MP0003385_abnormal_body_wall0.64339062
104MP0002751_abnormal_autonomic_nervous0.63156934
105MP0000428_abnormal_craniofacial_morphol0.62938075
106MP0001727_abnormal_embryo_implantation0.62715176
107MP0003935_abnormal_craniofacial_develop0.62649322
108MP0009379_abnormal_foot_pigmentation0.62079760
109MP0003698_abnormal_male_reproductive0.61909539
110MP0001915_intracranial_hemorrhage0.61771521
111MP0008260_abnormal_autophagy0.61528725
112MP0002095_abnormal_skin_pigmentation0.61226462
113MP0004133_heterotaxia0.60786076
114MP0002938_white_spotting0.59053752
115MP0006072_abnormal_retinal_apoptosis0.58938660
116MP0005023_abnormal_wound_healing0.58758467
117MP0003656_abnormal_erythrocyte_physiolo0.58248521
118MP0000049_abnormal_middle_ear0.58158783
119MP0004147_increased_porphyrin_level0.57857474
120MP0003938_abnormal_ear_development0.57597529
121MP0002161_abnormal_fertility/fecundity0.57390085
122MP0009250_abnormal_appendicular_skeleto0.57041696
123MP0002177_abnormal_outer_ear0.56645443
124MP0009278_abnormal_bone_marrow0.56049831
125MP0005408_hypopigmentation0.55591376
126MP0000432_abnormal_head_morphology0.55064929
127MP0000537_abnormal_urethra_morphology0.54995433
128MP0009697_abnormal_copulation0.54676695
129MP0003221_abnormal_cardiomyocyte_apopto0.54480301
130MP0000477_abnormal_intestine_morphology0.53202774
131MP0001853_heart_inflammation0.52963625
132MP0002092_abnormal_eye_morphology0.52837223

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.08778231
2Chromsome breakage (HP:0040012)4.75449488
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.69009697
4Breast hypoplasia (HP:0003187)4.43099783
5Reticulocytopenia (HP:0001896)4.36471049
6Patellar aplasia (HP:0006443)3.91876442
7Meckel diverticulum (HP:0002245)3.89230564
8Aplasia/Hypoplasia of the patella (HP:0006498)3.69920820
9Abnormality of the ileum (HP:0001549)3.67767601
10Abnormality of the preputium (HP:0100587)3.63907969
11Carpal bone hypoplasia (HP:0001498)3.63425958
12Abnormality of chromosome stability (HP:0003220)3.61630410
13Oral leukoplakia (HP:0002745)3.58677793
14Abnormality of cells of the erythroid lineage (HP:0012130)3.49684863
15Aplasia/Hypoplasia of the uvula (HP:0010293)3.42490547
16Abnormal number of erythroid precursors (HP:0012131)3.40335408
17Small intestinal stenosis (HP:0012848)3.26260038
18Duodenal stenosis (HP:0100867)3.26260038
19Absent radius (HP:0003974)3.10947453
20Colon cancer (HP:0003003)3.07581024
21Rough bone trabeculation (HP:0100670)2.99487343
22Myelodysplasia (HP:0002863)2.91171624
23Impulsivity (HP:0100710)2.90237962
24Absent forearm bone (HP:0003953)2.89881093
25Aplasia involving forearm bones (HP:0009822)2.89881093
26Selective tooth agenesis (HP:0001592)2.89815067
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.89730540
28Absent thumb (HP:0009777)2.88515226
29Aplastic anemia (HP:0001915)2.88094058
30Duplicated collecting system (HP:0000081)2.85575630
31Medulloblastoma (HP:0002885)2.81648762
32Abnormality of the anterior horn cell (HP:0006802)2.81408111
33Degeneration of anterior horn cells (HP:0002398)2.81408111
34Abnormal lung lobation (HP:0002101)2.78448772
35Abnormality of glycolysis (HP:0004366)2.74890109
36Bone marrow hypocellularity (HP:0005528)2.74763056
37Microretrognathia (HP:0000308)2.70525709
38Sloping forehead (HP:0000340)2.64894334
39Abnormality of the duodenum (HP:0002246)2.60469558
40Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.56371765
41Ectopic kidney (HP:0000086)2.55992298
42Pallor (HP:0000980)2.55685595
43Macrocytic anemia (HP:0001972)2.54629910
44Cortical dysplasia (HP:0002539)2.52100515
45Increased serum pyruvate (HP:0003542)2.49986756
46Triphalangeal thumb (HP:0001199)2.49832870
47Premature graying of hair (HP:0002216)2.47384260
48Abnormality of the renal collecting system (HP:0004742)2.47096269
49Premature ovarian failure (HP:0008209)2.46282122
50Hypoplastic pelvis (HP:0008839)2.45731905
51Horseshoe kidney (HP:0000085)2.43719760
52Acute necrotizing encephalopathy (HP:0006965)2.43200082
53Hypoplasia of the capital femoral epiphysis (HP:0003090)2.41082277
54Acute encephalopathy (HP:0006846)2.40995040
5511 pairs of ribs (HP:0000878)2.40806237
56Volvulus (HP:0002580)2.39889437
57Nephroblastoma (Wilms tumor) (HP:0002667)2.37726274
58Cerebral hypomyelination (HP:0006808)2.36751222
59Neoplasm of the pancreas (HP:0002894)2.36104026
60Tracheoesophageal fistula (HP:0002575)2.34912365
61Secondary amenorrhea (HP:0000869)2.34766594
62Clubbing of toes (HP:0100760)2.26299711
63Abnormality of the carotid arteries (HP:0005344)2.26120345
64Abnormal mitochondria in muscle tissue (HP:0008316)2.25292416
65Increased nuchal translucency (HP:0010880)2.22342081
66Supernumerary spleens (HP:0009799)2.22014781
67Agnosia (HP:0010524)2.22002525
68Abnormal trabecular bone morphology (HP:0100671)2.21583356
69Embryonal renal neoplasm (HP:0011794)2.20366152
70Abnormality of the labia minora (HP:0012880)2.18849338
71Cellular immunodeficiency (HP:0005374)2.18500810
72Short thumb (HP:0009778)2.18412569
73Increased CSF lactate (HP:0002490)2.18405787
74Abnormal number of incisors (HP:0011064)2.14243476
75Facial cleft (HP:0002006)2.13543677
76Rhabdomyosarcoma (HP:0002859)2.12377064
77Cleft eyelid (HP:0000625)2.11781314
78Increased hepatocellular lipid droplets (HP:0006565)2.11330589
79Atresia of the external auditory canal (HP:0000413)2.10191320
80Glioma (HP:0009733)2.09427228
81Trismus (HP:0000211)2.07033528
82Abnormality of DNA repair (HP:0003254)2.05067547
83Mitochondrial inheritance (HP:0001427)2.02124042
84Hepatocellular necrosis (HP:0001404)1.99987454
85Ureteral duplication (HP:0000073)1.98427421
86Microvesicular hepatic steatosis (HP:0001414)1.97383102
87Cafe-au-lait spot (HP:0000957)1.97333290
88Abnormality of the fetal cardiovascular system (HP:0010948)1.97212172
89Abnormal umbilical cord blood vessels (HP:0011403)1.97212172
90Single umbilical artery (HP:0001195)1.97212172
91Abnormality of the umbilical cord (HP:0010881)1.94951778
92Neoplasm of the colon (HP:0100273)1.93349149
93Increased serum lactate (HP:0002151)1.92300451
94Ependymoma (HP:0002888)1.91302671
95Choanal atresia (HP:0000453)1.89432441
96Astrocytoma (HP:0009592)1.87761007
97Abnormality of the astrocytes (HP:0100707)1.87761007
98Lipid accumulation in hepatocytes (HP:0006561)1.86939932
99Multiple enchondromatosis (HP:0005701)1.86657315
100Broad distal phalanx of finger (HP:0009836)1.86224990
101Aplasia/Hypoplasia of the sternum (HP:0006714)1.85966031
102Abnormality of methionine metabolism (HP:0010901)1.85123210
103Abnormality of the heme biosynthetic pathway (HP:0010472)1.85064276
104Embryonal neoplasm (HP:0002898)1.84702755
105Squamous cell carcinoma (HP:0002860)1.83720874
106Type I transferrin isoform profile (HP:0003642)1.83075270
107Progressive macrocephaly (HP:0004481)1.81029991
108Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79907315
109Absent epiphyses (HP:0010577)1.79907315
110Pancytopenia (HP:0001876)1.78358940
111Duplication of thumb phalanx (HP:0009942)1.77678933
112Aplasia/Hypoplasia of the breasts (HP:0010311)1.76058196
113Abnormality of reticulocytes (HP:0004312)1.75982863
114Cerebral edema (HP:0002181)1.74300224
115Abnormality of pyrimidine metabolism (HP:0004353)1.73758922
116High anterior hairline (HP:0009890)1.73435356
117Breast aplasia (HP:0100783)1.72763256
118Hypoplasia of the radius (HP:0002984)1.72427425
119Irregular epiphyses (HP:0010582)1.72268702
120Abdominal situs inversus (HP:0003363)1.72202390
121Abnormality of abdominal situs (HP:0011620)1.72202390
122Slender long bone (HP:0003100)1.71228125
123High pitched voice (HP:0001620)1.71011521
124Hepatic necrosis (HP:0002605)1.70168051
125Preaxial hand polydactyly (HP:0001177)1.69800542
126Abnormal spermatogenesis (HP:0008669)1.68360488
127Short middle phalanx of the 5th finger (HP:0004220)1.68271711
128Facial hemangioma (HP:0000329)1.68151390
129Aplasia/Hypoplasia of the earlobes (HP:0009906)1.67417632
130Proximal placement of thumb (HP:0009623)1.67247659
131Lymphoma (HP:0002665)1.66184509
132Cutaneous melanoma (HP:0012056)1.64723309
133Deviation of the thumb (HP:0009603)1.62820099
134Arteriovenous malformation (HP:0100026)1.62767068
135Basal cell carcinoma (HP:0002671)1.60969385
136Abnormal gallbladder physiology (HP:0012438)1.59118799
137Cholecystitis (HP:0001082)1.59118799
138Reduced antithrombin III activity (HP:0001976)1.58434633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.30276798
2WEE14.56473162
3CDC73.85618846
4NEK23.37194761
5EIF2AK13.15639767
6VRK23.02108133
7TTK3.01313286
8PLK42.99307425
9SRPK12.69929173
10BRSK22.44731888
11NEK12.26523885
12STK162.21240991
13* PLK12.20787358
14TRIM282.12076142
15VRK11.98915314
16ACVR1B1.94150374
17NME21.91404911
18* AURKB1.90385889
19BRSK11.88083759
20TLK11.79519812
21CCNB11.68636218
22PLK31.68500056
23TESK21.66139720
24CHEK21.64737895
25EIF2AK31.62255605
26CDK71.55558374
27AURKA1.54434286
28TAF11.53291525
29MKNK11.49023434
30ATR1.47599456
31RPS6KA41.46677408
32MAP3K81.45843205
33STK41.39258532
34DYRK31.37262916
35STK101.36424615
36RPS6KB21.34810609
37ZAK1.34731390
38EPHA21.30939470
39TSSK61.27065555
40CDK41.22643631
41BRAF1.17137562
42MKNK21.16664782
43CHEK11.13979436
44PBK1.07895123
45EIF2AK21.06974301
46MELK1.01499700
47CDK120.98160382
48PASK0.98147158
49CDK80.97983226
50SMG10.96549041
51EEF2K0.91464705
52PAK40.87571822
53ATM0.81498362
54STK38L0.81466561
55MST1R0.80411705
56PDK20.79181097
57PLK20.77493472
58STK30.73174298
59PAK10.72330317
60PIM10.71921141
61* CDK20.71396396
62BMPR1B0.69468901
63KDR0.69185993
64* CDK10.62842051
65* CSNK2A10.59168507
66CLK10.57414104
67BCR0.56529149
68LATS20.55045397
69WNK30.54282736
70RPS6KA50.53986379
71TESK10.53595092
72TGFBR10.53143775
73CDK60.51177167
74TNIK0.50324741
75CSNK2A20.50111808
76SIK30.49910739
77PRKCI0.48871143
78MAPKAPK30.48232673
79DYRK20.48151861
80ERBB40.46630756
81ERBB30.45758935
82CSNK1G30.45679494
83BRD40.44852133
84SCYL20.43791566
85CDK180.43606499
86CSNK1G10.42227875
87PIM20.41620446
88MET0.40153891
89MAP3K100.39841721
90MAP4K10.39787170
91NUAK10.37446669
92LRRK20.36537492
93MAP3K110.35829277
94CDK140.35511116
95MINK10.34024511
96MARK30.33792426
97CSNK1A1L0.32910855
98LIMK10.32785896
99ABL20.32228643
100BCKDK0.31966483
101PNCK0.30945710
102FGFR10.30387630
103AKT20.28640392
104NEK90.28136420
105DAPK10.26301825
106BLK0.25129882
107LATS10.24295277
108ILK0.24228130
109IRAK40.23309337
110IRAK30.22979404
111MAP3K60.22862834
112PRKDC0.22557783
113CSNK1G20.21927124
114NME10.21857614
115RAF10.21288338
116TAOK20.18449609
117MAPKAPK20.18428135
118ALK0.18017617
119TIE10.17128898
120CDK11A0.17103757
121MST40.16743766
122UHMK10.16224516
123MAPKAPK50.16114502
124MAPK110.15571838
125AKT10.15023697
126CDK150.14251345
127CSNK1E0.13955368
128AKT30.13901295
129FLT30.13539911

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.98101293
2Mismatch repair_Homo sapiens_hsa034304.27002495
3Ribosome_Homo sapiens_hsa030103.41965246
4Proteasome_Homo sapiens_hsa030503.40859329
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.38961012
6Homologous recombination_Homo sapiens_hsa034403.38950153
7Spliceosome_Homo sapiens_hsa030403.28006111
8RNA polymerase_Homo sapiens_hsa030203.27939261
9Cell cycle_Homo sapiens_hsa041103.22805115
10Base excision repair_Homo sapiens_hsa034103.19731218
11RNA transport_Homo sapiens_hsa030133.08295829
12Nucleotide excision repair_Homo sapiens_hsa034202.99974648
13Fanconi anemia pathway_Homo sapiens_hsa034602.71605570
14Pyrimidine metabolism_Homo sapiens_hsa002402.57666329
15One carbon pool by folate_Homo sapiens_hsa006702.37550879
16Non-homologous end-joining_Homo sapiens_hsa034502.16783931
17Basal transcription factors_Homo sapiens_hsa030222.14096968
18RNA degradation_Homo sapiens_hsa030182.08716329
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06091216
20p53 signaling pathway_Homo sapiens_hsa041151.85599148
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66565997
22mRNA surveillance pathway_Homo sapiens_hsa030151.65849864
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45822751
24Pyruvate metabolism_Homo sapiens_hsa006201.40473845
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36935184
26Purine metabolism_Homo sapiens_hsa002301.36216382
27Systemic lupus erythematosus_Homo sapiens_hsa053221.35675302
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30407467
29Oocyte meiosis_Homo sapiens_hsa041141.27650337
30Epstein-Barr virus infection_Homo sapiens_hsa051691.20852897
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19418051
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14741556
33Fatty acid elongation_Homo sapiens_hsa000621.09449613
34Steroid biosynthesis_Homo sapiens_hsa001001.07345566
35Vitamin B6 metabolism_Homo sapiens_hsa007501.06612388
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04416112
37Propanoate metabolism_Homo sapiens_hsa006401.01046389
38Herpes simplex infection_Homo sapiens_hsa051680.91094744
39Viral carcinogenesis_Homo sapiens_hsa052030.87540368
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78991563
41Alzheimers disease_Homo sapiens_hsa050100.78395912
42HTLV-I infection_Homo sapiens_hsa051660.75718215
43Pentose phosphate pathway_Homo sapiens_hsa000300.75516385
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74425840
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71771121
46Protein export_Homo sapiens_hsa030600.71192884
47Folate biosynthesis_Homo sapiens_hsa007900.69210151
48Antigen processing and presentation_Homo sapiens_hsa046120.68473441
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68004246
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67970659
51MicroRNAs in cancer_Homo sapiens_hsa052060.66655097
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66648559
53Huntingtons disease_Homo sapiens_hsa050160.66570217
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65218466
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.64408125
56Small cell lung cancer_Homo sapiens_hsa052220.62893856
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.60745370
58Lysine degradation_Homo sapiens_hsa003100.54874933
59Glutathione metabolism_Homo sapiens_hsa004800.54734103
60Biosynthesis of amino acids_Homo sapiens_hsa012300.49381261
61TGF-beta signaling pathway_Homo sapiens_hsa043500.46139108
62Primary immunodeficiency_Homo sapiens_hsa053400.46013270
63Selenocompound metabolism_Homo sapiens_hsa004500.45707137
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44424848
65Arginine and proline metabolism_Homo sapiens_hsa003300.42021730
66Alcoholism_Homo sapiens_hsa050340.41869899
67Parkinsons disease_Homo sapiens_hsa050120.39144838
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.37142164
69Thyroid cancer_Homo sapiens_hsa052160.37006032
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36678624
71Legionellosis_Homo sapiens_hsa051340.36571414
72Fatty acid metabolism_Homo sapiens_hsa012120.35790370
73* Apoptosis_Homo sapiens_hsa042100.34666634
74Basal cell carcinoma_Homo sapiens_hsa052170.34193953
75Sulfur relay system_Homo sapiens_hsa041220.33482814
76Shigellosis_Homo sapiens_hsa051310.33410196
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32175002
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32162890
79Wnt signaling pathway_Homo sapiens_hsa043100.31611074
80* Hippo signaling pathway_Homo sapiens_hsa043900.31439474
81Arachidonic acid metabolism_Homo sapiens_hsa005900.30474631
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.28234508
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27860079
84Measles_Homo sapiens_hsa051620.27798200
85Sulfur metabolism_Homo sapiens_hsa009200.27571288
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27252018
87Bladder cancer_Homo sapiens_hsa052190.27185952
88Notch signaling pathway_Homo sapiens_hsa043300.26429294
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24776329
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23170382
91* Hepatitis B_Homo sapiens_hsa051610.23091517
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.23078669
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22278732
94Fructose and mannose metabolism_Homo sapiens_hsa000510.22113570
95Hematopoietic cell lineage_Homo sapiens_hsa046400.22106103
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21971025
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21725493
98N-Glycan biosynthesis_Homo sapiens_hsa005100.21452651
99Metabolic pathways_Homo sapiens_hsa011000.21112602
100Hedgehog signaling pathway_Homo sapiens_hsa043400.20359803
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20191811
102Regulation of autophagy_Homo sapiens_hsa041400.19969402
103Carbon metabolism_Homo sapiens_hsa012000.19808793
104Influenza A_Homo sapiens_hsa051640.18402018
105* Pathways in cancer_Homo sapiens_hsa052000.17604305
106Oxidative phosphorylation_Homo sapiens_hsa001900.17585504
107Asthma_Homo sapiens_hsa053100.16968009
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.16078708
109HIF-1 signaling pathway_Homo sapiens_hsa040660.15267708
110Peroxisome_Homo sapiens_hsa041460.14986674
111Chronic myeloid leukemia_Homo sapiens_hsa052200.14347085
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14315030
113Butanoate metabolism_Homo sapiens_hsa006500.14122647
114Tyrosine metabolism_Homo sapiens_hsa003500.13386016
115Melanoma_Homo sapiens_hsa052180.13097969
116Linoleic acid metabolism_Homo sapiens_hsa005910.12578853
117* Colorectal cancer_Homo sapiens_hsa052100.12391490
118FoxO signaling pathway_Homo sapiens_hsa040680.12215520
119Adherens junction_Homo sapiens_hsa045200.12129580
120Cardiac muscle contraction_Homo sapiens_hsa042600.11160578
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11136503
122Prostate cancer_Homo sapiens_hsa052150.11082969
123beta-Alanine metabolism_Homo sapiens_hsa004100.10965485
124Pancreatic cancer_Homo sapiens_hsa052120.10311840
125Fatty acid degradation_Homo sapiens_hsa000710.09238621
126Renin-angiotensin system_Homo sapiens_hsa046140.08604426
127Viral myocarditis_Homo sapiens_hsa054160.08227307
128Tight junction_Homo sapiens_hsa045300.07171702
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.06493777
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06192594
131Galactose metabolism_Homo sapiens_hsa000520.05640116

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »