ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitotic metaphase plate congression (GO:0007080)	5.57395220
2	protein localization to kinetochore (GO:0034501)	5.35367187
3	kinetochore organization (GO:0051383)	5.16098265
4	CENP-A containing nucleosome assembly (GO:0034080)	4.97932171
5	protein localization to chromosome, centromeric region (GO:0071459)	4.94705885
6	kinetochore assembly (GO:0051382)	4.86882803
7	metaphase plate congression (GO:0051310)	4.84485012
8	chromatin remodeling at centromere (GO:0031055)	4.82645755
9	mitotic sister chromatid segregation (GO:0000070)	4.82034095
10	attachment of spindle microtubules to kinetochore (GO:0008608)	4.66724769
11	DNA strand elongation involved in DNA replication (GO:0006271)	4.57039224
12	DNA ligation (GO:0006266)	4.53085645
13	telomere maintenance via semi-conservative replication (GO:0032201)	4.45967031
14	mitotic chromosome condensation (GO:0007076)	4.44391440
15	establishment of integrated proviral latency (GO:0075713)	4.40667714
16	DNA replication-independent nucleosome assembly (GO:0006336)	4.39471521
17	DNA replication-independent nucleosome organization (GO:0034724)	4.39471521
18	DNA replication checkpoint (GO:0000076)	4.37960115
19	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.37934409
20	DNA strand elongation (GO:0022616)	4.34498782
21	sister chromatid segregation (GO:0000819)	4.33705468
22	DNA replication initiation (GO:0006270)	4.30145768
23	regulation of spindle organization (GO:0090224)	4.25136815
24	* establishment of chromosome localization (GO:0051303)	4.22517591
25	telomere maintenance via recombination (GO:0000722)	4.12934338
26	histone exchange (GO:0043486)	4.12904203
27	DNA topological change (GO:0006265)	4.03591971
28	mitotic recombination (GO:0006312)	4.03080225
29	mitotic nuclear envelope disassembly (GO:0007077)	3.97075519
30	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.92927270
31	meiotic chromosome segregation (GO:0045132)	3.91786485
32	DNA replication-dependent nucleosome organization (GO:0034723)	3.83941384
33	DNA replication-dependent nucleosome assembly (GO:0006335)	3.83941384
34	nuclear pore complex assembly (GO:0051292)	3.83579649
35	DNA unwinding involved in DNA replication (GO:0006268)	3.76275800
36	* spindle checkpoint (GO:0031577)	3.73566065
37	telomere maintenance via telomere lengthening (GO:0010833)	3.71487627
38	regulation of chromosome segregation (GO:0051983)	3.71484827
39	negative regulation of chromosome segregation (GO:0051985)	3.69462001
40	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.69093442
41	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.69093442
42	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.69093442
43	negative regulation of sister chromatid segregation (GO:0033046)	3.69093442
44	spindle assembly checkpoint (GO:0071173)	3.67820404
45	ribosomal small subunit assembly (GO:0000028)	3.65019848
46	nuclear envelope disassembly (GO:0051081)	3.64502321
47	membrane disassembly (GO:0030397)	3.64502321
48	maturation of SSU-rRNA (GO:0030490)	3.64057638
49	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.62769356
50	mitotic spindle assembly checkpoint (GO:0007094)	3.60066398
51	protein localization to chromosome (GO:0034502)	3.59351283
52	regulation of mitotic spindle organization (GO:0060236)	3.58841660
53	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.58650753
54	DNA deamination (GO:0045006)	3.57144815
55	mitotic spindle checkpoint (GO:0071174)	3.55685455
56	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.55152725
57	protein K6-linked ubiquitination (GO:0085020)	3.55070159
58	positive regulation of chromosome segregation (GO:0051984)	3.54857960
59	* chromosome segregation (GO:0007059)	3.52367453
60	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	3.50582766
61	mitotic sister chromatid cohesion (GO:0007064)	3.46558200
62	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.46211568
63	nucleobase biosynthetic process (GO:0046112)	3.40760543
64	regulation of mitotic sister chromatid segregation (GO:0033047)	3.39721591
65	regulation of sister chromatid segregation (GO:0033045)	3.39721591
66	regulation of mitotic sister chromatid separation (GO:0010965)	3.39721591
67	establishment of viral latency (GO:0019043)	3.37846978
68	regulation of centriole replication (GO:0046599)	3.37738262
69	formation of translation preinitiation complex (GO:0001731)	3.35903586
70	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.34238176
71	non-recombinational repair (GO:0000726)	3.30644307
72	double-strand break repair via nonhomologous end joining (GO:0006303)	3.30644307
73	regulation of sister chromatid cohesion (GO:0007063)	3.30172988
74	ventricular cardiac muscle cell development (GO:0055015)	3.29717545
75	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.28177143
76	chromatin assembly or disassembly (GO:0006333)	3.27904499
77	proteasome assembly (GO:0043248)	3.27293046
78	ribosomal large subunit biogenesis (GO:0042273)	3.27145735
79	replication fork processing (GO:0031297)	3.25198841
80	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.24739019
81	regulation of centrosome cycle (GO:0046605)	3.24665427
82	ribosome assembly (GO:0042255)	3.24448453
83	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.22584325
84	purine nucleobase biosynthetic process (GO:0009113)	3.22226581
85	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.20203355
86	DNA packaging (GO:0006323)	3.20177702
87	microtubule depolymerization (GO:0007019)	3.19047360
88	ATP-dependent chromatin remodeling (GO:0043044)	3.18789450
89	spliceosomal snRNP assembly (GO:0000387)	3.17032180
90	viral transcription (GO:0019083)	3.15227907
91	transcription-coupled nucleotide-excision repair (GO:0006283)	3.15099321
92	IMP biosynthetic process (GO:0006188)	3.14729548
93	rRNA modification (GO:0000154)	3.14121131
94	translational termination (GO:0006415)	3.13557773
95	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.13000579
96	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.13000579
97	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.13000579
98	nuclear pore organization (GO:0006999)	3.10940900
99	* mitotic cell cycle (GO:0000278)	3.10079806
100	ribosomal small subunit biogenesis (GO:0042274)	3.08419672
101	ribonucleoprotein complex biogenesis (GO:0022613)	3.07312248
102	ribosome biogenesis (GO:0042254)	3.04859660
103	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.04753544
104	negative regulation of mitosis (GO:0045839)	3.01228176
105	regulation of ubiquitin-protein transferase activity (GO:0051438)	3.01113950
106	cell cycle G1/S phase transition (GO:0044843)	3.00851945
107	G1/S transition of mitotic cell cycle (GO:0000082)	3.00851945
108	chromosome condensation (GO:0030261)	3.00272233
109	DNA strand renaturation (GO:0000733)	3.00110792
110	translational initiation (GO:0006413)	2.98354576
111	rRNA processing (GO:0006364)	2.97215925
112	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.94819321
113	negative regulation of ligase activity (GO:0051352)	2.94819321
114	telomere maintenance (GO:0000723)	2.94125311
115	telomere organization (GO:0032200)	2.93891732
116	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.93537200
117	mismatch repair (GO:0006298)	2.92980042
118	positive regulation of ligase activity (GO:0051351)	2.92050483
119	negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)	2.91177331
120	regulation of ligase activity (GO:0051340)	2.90480487
121	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.90168715

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	8.90431679
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	6.12361166
3	* E2F4_17652178_ChIP-ChIP_JURKAT_Human	4.29680298
4	* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	4.12080139
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.07948876
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.53967503
7	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.40259334
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.00341052
9	* MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.83726568
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.82994402
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.75941036
12	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.74015482
13	* ETS1_20019798_ChIP-Seq_JURKAT_Human	2.72773247
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.72573035
15	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.71937736
16	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.70069967
17	AR_21909140_ChIP-Seq_LNCAP_Human	2.60836531
18	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.37302813
19	* NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.32570162
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.30400556
21	* XRN2_22483619_ChIP-Seq_HELA_Human	2.27952837
22	VDR_23849224_ChIP-Seq_CD4+_Human	2.17377705
23	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	2.17205008
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.12798418
25	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.12078206
26	DCP1A_22483619_ChIP-Seq_HELA_Human	2.00670633
27	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.97438424
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.94272421
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93304246
30	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.89818902
31	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.88254462
32	* MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.83611433
33	TTF2_22483619_ChIP-Seq_HELA_Human	1.82729004
34	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.81448991
35	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.81215420
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.79128083
37	* KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.71283291
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.69451400
39	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.69401866
40	ELK1_19687146_ChIP-ChIP_HELA_Human	1.65114733
41	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.63313177
42	* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.60782628
43	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.60285657
44	CIITA_25753668_ChIP-Seq_RAJI_Human	1.53249075
45	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.53158060
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.51738496
47	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.50188892
48	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.45991540
49	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.45717826
50	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.42598384
51	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.40709385
52	KDM5A_27292631_Chip-Seq_BREAST_Human	1.39621502
53	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.38235020
54	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.37315261
55	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.34162088
56	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.32078513
57	* TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.31192061
58	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.29864626
59	* CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.25657282
60	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.22798239
61	MYC_22102868_ChIP-Seq_BL_Human	1.13197141
62	* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.12604418
63	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.12105417
64	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.12060713
65	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.10322706
66	MYC_18940864_ChIP-ChIP_HL60_Human	1.10303067
67	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.10136870
68	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.10116212
69	* KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.09976376
70	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.09705865
71	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.08461183
72	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.08020220
73	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.06300864
74	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.03111696
75	* KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.02390538
76	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.01912286
77	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.01459243
78	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.01119649
79	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.00603582
80	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.98269854
81	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.96855896
82	TFEB_21752829_ChIP-Seq_HELA_Human	0.94321606
83	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.93829978
84	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.89655860
85	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.89558851
86	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.88837901
87	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.88420999
88	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.88101121
89	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.87357570
90	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.86473564
91	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.86393974
92	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.83410585
93	SPI1_23547873_ChIP-Seq_NB4_Human	0.81186234
94	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.80068202
95	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.76707642
96	EWS_26573619_Chip-Seq_HEK293_Human	0.75048151
97	* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.74811107
98	VDR_21846776_ChIP-Seq_THP-1_Human	0.74546812
99	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.74047935
100	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.73793991
101	* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.73551764
102	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.72253904
103	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.71814943
104	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.71590894
105	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.71526328
106	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.70838164
107	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.70793914
108	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.70682723
109	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.69632693
110	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.69577548
111	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.69081399
112	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.67959902
113	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.66578472
114	CHD1_26751641_Chip-Seq_LNCaP_Human	0.65889479
115	* TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.65705646

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	* MP0003693_abnormal_embryo_hatching	5.87867746
2	* MP0003111_abnormal_nucleus_morphology	5.17840446
3	MP0010094_abnormal_chromosome_stability	4.98579102
4	* MP0004957_abnormal_blastocyst_morpholog	4.56803988
5	* MP0003077_abnormal_cell_cycle	4.46983027
6	MP0008057_abnormal_DNA_replication	3.79303201
7	MP0008058_abnormal_DNA_repair	3.36853573
8	MP0008007_abnormal_cellular_replicative	3.03115112
9	MP0008932_abnormal_embryonic_tissue	3.00796266
10	MP0003718_maternal_effect	2.52642654
11	MP0003123_paternal_imprinting	2.43613657
12	MP0003136_yellow_coat_color	2.33863487
13	MP0001730_embryonic_growth_arrest	2.30275939
14	MP0000372_irregular_coat_pigmentation	2.29715522
15	MP0000350_abnormal_cell_proliferation	2.19490255
16	MP0002396_abnormal_hematopoietic_system	2.07203369
17	MP0008877_abnormal_DNA_methylation	2.06250217
18	MP0005171_absent_coat_pigmentation	1.98723123
19	MP0003786_premature_aging	1.94503965
20	MP0005380_embryogenesis_phenotype	1.75177593
21	MP0001672_abnormal_embryogenesis/_devel	1.75177593
22	MP0001697_abnormal_embryo_size	1.73584208
23	MP0000490_abnormal_crypts_of	1.70798562
24	MP0010307_abnormal_tumor_latency	1.65263316
25	MP0010030_abnormal_orbit_morphology	1.57008186
26	* MP0002085_abnormal_embryonic_tissue	1.53627797
27	* MP0002080_prenatal_lethality	1.52388743
28	MP0003984_embryonic_growth_retardation	1.49476250
29	MP0003315_abnormal_perineum_morphology	1.49121966
30	MP0002088_abnormal_embryonic_growth/wei	1.45713644
31	MP0002019_abnormal_tumor_incidence	1.43606646
32	* MP0000313_abnormal_cell_death	1.43300875
33	MP0010352_gastrointestinal_tract_polyps	1.41679290
34	MP0002210_abnormal_sex_determination	1.40224339
35	MP0006292_abnormal_olfactory_placode	1.38793282
36	MP0002877_abnormal_melanocyte_morpholog	1.34992641
37	MP0002084_abnormal_developmental_patter	1.29226582
38	* MP0002086_abnormal_extraembryonic_tissu	1.27509210
39	MP0004808_abnormal_hematopoietic_stem	1.25597429
40	MP0003121_genomic_imprinting	1.25265588
41	MP0002102_abnormal_ear_morphology	1.24537470
42	MP0001929_abnormal_gametogenesis	1.19243536
43	MP0003567_abnormal_fetal_cardiomyocyte	1.17965736
44	MP0006035_abnormal_mitochondrial_morpho	1.17926553
45	MP0001145_abnormal_male_reproductive	1.17672192
46	MP0002697_abnormal_eye_size	1.17351724
47	MP0009333_abnormal_splenocyte_physiolog	1.17176961
48	MP0001346_abnormal_lacrimal_gland	1.16714530
49	MP0001119_abnormal_female_reproductive	1.13959865
50	MP0004197_abnormal_fetal_growth/weight/	1.10898532
51	MP0000653_abnormal_sex_gland	1.09569250
52	MP0001529_abnormal_vocalization	1.06926387
53	MP0001545_abnormal_hematopoietic_system	1.05851129
54	MP0005397_hematopoietic_system_phenotyp	1.05851129
55	MP0003937_abnormal_limbs/digits/tail_de	1.03164361
56	MP0001293_anophthalmia	1.02555127
57	MP0005076_abnormal_cell_differentiation	1.01656992
58	MP0000015_abnormal_ear_pigmentation	1.00010761
59	MP0002233_abnormal_nose_morphology	0.94901180
60	MP0003186_abnormal_redox_activity	0.94644131
61	MP0000566_synostosis	0.94315286
62	* MP0000703_abnormal_thymus_morphology	0.93752821
63	MP0005389_reproductive_system_phenotype	0.93334554
64	MP0002234_abnormal_pharynx_morphology	0.93117601
65	MP0003890_abnormal_embryonic-extraembry	0.91912512
66	MP0009053_abnormal_anal_canal	0.90555071
67	MP0008789_abnormal_olfactory_epithelium	0.89631435
68	MP0003941_abnormal_skin_development	0.89370112
69	MP0003763_abnormal_thymus_physiology	0.89344832
70	MP0002160_abnormal_reproductive_system	0.89061415
71	MP0002132_abnormal_respiratory_system	0.88252743
72	MP0000858_altered_metastatic_potential	0.87680667
73	* MP0002398_abnormal_bone_marrow	0.87100859
74	* MP0002722_abnormal_immune_system	0.84928131
75	MP0003755_abnormal_palate_morphology	0.82545451
76	MP0000689_abnormal_spleen_morphology	0.81817042
77	MP0006054_spinal_hemorrhage	0.81747770
78	MP0002111_abnormal_tail_morphology	0.81082861
79	MP0001919_abnormal_reproductive_system	0.80830105
80	MP0003806_abnormal_nucleotide_metabolis	0.80418137
81	* MP0006036_abnormal_mitochondrial_physio	0.78373724
82	MP0005174_abnormal_tail_pigmentation	0.77934567
83	MP0005384_cellular_phenotype	0.77875604
84	MP0003861_abnormal_nervous_system	0.76624765
85	MP0000358_abnormal_cell_content/	0.76618821
86	MP0003950_abnormal_plasma_membrane	0.75828239
87	MP0005621_abnormal_cell_physiology	0.75215650
88	MP0005395_other_phenotype	0.75214932
89	MP0003119_abnormal_digestive_system	0.75020754
90	MP0003699_abnormal_female_reproductive	0.75011754
91	MP0002653_abnormal_ependyma_morphology	0.72567120
92	MP0004233_abnormal_muscle_weight	0.70389021
93	MP0000647_abnormal_sebaceous_gland	0.68827433
94	* MP0002429_abnormal_blood_cell	0.67673132
95	MP0009703_decreased_birth_body	0.67517275
96	MP0005623_abnormal_meninges_morphology	0.66988629
97	MP0001324_abnormal_eye_pigmentation	0.66817493
98	MP0001286_abnormal_eye_development	0.65879143
99	MP0009672_abnormal_birth_weight	0.65575654
100	MP0005075_abnormal_melanosome_morpholog	0.65292882
101	MP0003943_abnormal_hepatobiliary_system	0.64496951
102	MP0005391_vision/eye_phenotype	0.64354933
103	MP0003385_abnormal_body_wall	0.64339062
104	MP0002751_abnormal_autonomic_nervous	0.63156934
105	MP0000428_abnormal_craniofacial_morphol	0.62938075
106	MP0001727_abnormal_embryo_implantation	0.62715176
107	MP0003935_abnormal_craniofacial_develop	0.62649322
108	MP0009379_abnormal_foot_pigmentation	0.62079760
109	MP0003698_abnormal_male_reproductive	0.61909539
110	MP0001915_intracranial_hemorrhage	0.61771521
111	MP0008260_abnormal_autophagy	0.61528725
112	MP0002095_abnormal_skin_pigmentation	0.61226462
113	MP0004133_heterotaxia	0.60786076
114	MP0002938_white_spotting	0.59053752
115	MP0006072_abnormal_retinal_apoptosis	0.58938660
116	MP0005023_abnormal_wound_healing	0.58758467
117	MP0003656_abnormal_erythrocyte_physiolo	0.58248521
118	MP0000049_abnormal_middle_ear	0.58158783
119	MP0004147_increased_porphyrin_level	0.57857474
120	MP0003938_abnormal_ear_development	0.57597529
121	MP0002161_abnormal_fertility/fecundity	0.57390085
122	MP0009250_abnormal_appendicular_skeleto	0.57041696
123	MP0002177_abnormal_outer_ear	0.56645443
124	MP0009278_abnormal_bone_marrow	0.56049831
125	MP0005408_hypopigmentation	0.55591376
126	MP0000432_abnormal_head_morphology	0.55064929
127	MP0000537_abnormal_urethra_morphology	0.54995433
128	MP0009697_abnormal_copulation	0.54676695
129	MP0003221_abnormal_cardiomyocyte_apopto	0.54480301
130	MP0000477_abnormal_intestine_morphology	0.53202774
131	MP0001853_heart_inflammation	0.52963625
132	MP0002092_abnormal_eye_morphology	0.52837223

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Birth length less than 3rd percentile (HP:0003561)	5.08778231
2	Chromsome breakage (HP:0040012)	4.75449488
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.69009697
4	Breast hypoplasia (HP:0003187)	4.43099783
5	Reticulocytopenia (HP:0001896)	4.36471049
6	Patellar aplasia (HP:0006443)	3.91876442
7	Meckel diverticulum (HP:0002245)	3.89230564
8	Aplasia/Hypoplasia of the patella (HP:0006498)	3.69920820
9	Abnormality of the ileum (HP:0001549)	3.67767601
10	Abnormality of the preputium (HP:0100587)	3.63907969
11	Carpal bone hypoplasia (HP:0001498)	3.63425958
12	Abnormality of chromosome stability (HP:0003220)	3.61630410
13	Oral leukoplakia (HP:0002745)	3.58677793
14	Abnormality of cells of the erythroid lineage (HP:0012130)	3.49684863
15	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.42490547
16	Abnormal number of erythroid precursors (HP:0012131)	3.40335408
17	Duodenal stenosis (HP:0100867)	3.26260038
18	Small intestinal stenosis (HP:0012848)	3.26260038
19	Absent radius (HP:0003974)	3.10947453
20	Colon cancer (HP:0003003)	3.07581024
21	Rough bone trabeculation (HP:0100670)	2.99487343
22	Myelodysplasia (HP:0002863)	2.91171624
23	Impulsivity (HP:0100710)	2.90237962
24	Aplasia involving forearm bones (HP:0009822)	2.89881093
25	Absent forearm bone (HP:0003953)	2.89881093
26	Selective tooth agenesis (HP:0001592)	2.89815067
27	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.89730540
28	Absent thumb (HP:0009777)	2.88515226
29	Aplastic anemia (HP:0001915)	2.88094058
30	Duplicated collecting system (HP:0000081)	2.85575630
31	Medulloblastoma (HP:0002885)	2.81648762
32	Degeneration of anterior horn cells (HP:0002398)	2.81408111
33	Abnormality of the anterior horn cell (HP:0006802)	2.81408111
34	Abnormal lung lobation (HP:0002101)	2.78448772
35	Abnormality of glycolysis (HP:0004366)	2.74890109
36	Bone marrow hypocellularity (HP:0005528)	2.74763056
37	Microretrognathia (HP:0000308)	2.70525709
38	Sloping forehead (HP:0000340)	2.64894334
39	Abnormality of the duodenum (HP:0002246)	2.60469558
40	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.56371765
41	Ectopic kidney (HP:0000086)	2.55992298
42	Pallor (HP:0000980)	2.55685595
43	Macrocytic anemia (HP:0001972)	2.54629910
44	Cortical dysplasia (HP:0002539)	2.52100515
45	Increased serum pyruvate (HP:0003542)	2.49986756
46	Triphalangeal thumb (HP:0001199)	2.49832870
47	Premature graying of hair (HP:0002216)	2.47384260
48	Abnormality of the renal collecting system (HP:0004742)	2.47096269
49	Premature ovarian failure (HP:0008209)	2.46282122
50	Hypoplastic pelvis (HP:0008839)	2.45731905
51	Horseshoe kidney (HP:0000085)	2.43719760
52	Acute necrotizing encephalopathy (HP:0006965)	2.43200082
53	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.41082277
54	Acute encephalopathy (HP:0006846)	2.40995040
55	11 pairs of ribs (HP:0000878)	2.40806237
56	Volvulus (HP:0002580)	2.39889437
57	Nephroblastoma (Wilms tumor) (HP:0002667)	2.37726274
58	Cerebral hypomyelination (HP:0006808)	2.36751222
59	Neoplasm of the pancreas (HP:0002894)	2.36104026
60	Tracheoesophageal fistula (HP:0002575)	2.34912365
61	Secondary amenorrhea (HP:0000869)	2.34766594
62	Clubbing of toes (HP:0100760)	2.26299711
63	Abnormality of the carotid arteries (HP:0005344)	2.26120345
64	Abnormal mitochondria in muscle tissue (HP:0008316)	2.25292416
65	Increased nuchal translucency (HP:0010880)	2.22342081
66	Supernumerary spleens (HP:0009799)	2.22014781
67	Agnosia (HP:0010524)	2.22002525
68	Abnormal trabecular bone morphology (HP:0100671)	2.21583356
69	Embryonal renal neoplasm (HP:0011794)	2.20366152
70	Abnormality of the labia minora (HP:0012880)	2.18849338
71	Cellular immunodeficiency (HP:0005374)	2.18500810
72	Short thumb (HP:0009778)	2.18412569
73	Increased CSF lactate (HP:0002490)	2.18405787
74	Abnormal number of incisors (HP:0011064)	2.14243476
75	Facial cleft (HP:0002006)	2.13543677
76	Rhabdomyosarcoma (HP:0002859)	2.12377064
77	Cleft eyelid (HP:0000625)	2.11781314
78	Increased hepatocellular lipid droplets (HP:0006565)	2.11330589
79	Atresia of the external auditory canal (HP:0000413)	2.10191320
80	Glioma (HP:0009733)	2.09427228
81	Trismus (HP:0000211)	2.07033528
82	Abnormality of DNA repair (HP:0003254)	2.05067547
83	Mitochondrial inheritance (HP:0001427)	2.02124042
84	Hepatocellular necrosis (HP:0001404)	1.99987454
85	Ureteral duplication (HP:0000073)	1.98427421
86	Microvesicular hepatic steatosis (HP:0001414)	1.97383102
87	Cafe-au-lait spot (HP:0000957)	1.97333290
88	Abnormal umbilical cord blood vessels (HP:0011403)	1.97212172
89	Single umbilical artery (HP:0001195)	1.97212172
90	Abnormality of the fetal cardiovascular system (HP:0010948)	1.97212172
91	Abnormality of the umbilical cord (HP:0010881)	1.94951778
92	Neoplasm of the colon (HP:0100273)	1.93349149
93	Increased serum lactate (HP:0002151)	1.92300451
94	Ependymoma (HP:0002888)	1.91302671
95	Choanal atresia (HP:0000453)	1.89432441
96	Abnormality of the astrocytes (HP:0100707)	1.87761007
97	Astrocytoma (HP:0009592)	1.87761007
98	Lipid accumulation in hepatocytes (HP:0006561)	1.86939932
99	Multiple enchondromatosis (HP:0005701)	1.86657315
100	Broad distal phalanx of finger (HP:0009836)	1.86224990
101	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.85966031
102	Abnormality of methionine metabolism (HP:0010901)	1.85123210
103	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.85064276
104	Embryonal neoplasm (HP:0002898)	1.84702755
105	Squamous cell carcinoma (HP:0002860)	1.83720874
106	Type I transferrin isoform profile (HP:0003642)	1.83075270
107	Progressive macrocephaly (HP:0004481)	1.81029991
108	Absent epiphyses (HP:0010577)	1.79907315
109	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.79907315
110	Pancytopenia (HP:0001876)	1.78358940
111	Duplication of thumb phalanx (HP:0009942)	1.77678933
112	Aplasia/Hypoplasia of the breasts (HP:0010311)	1.76058196
113	Abnormality of reticulocytes (HP:0004312)	1.75982863
114	Cerebral edema (HP:0002181)	1.74300224
115	Abnormality of pyrimidine metabolism (HP:0004353)	1.73758922
116	High anterior hairline (HP:0009890)	1.73435356
117	Breast aplasia (HP:0100783)	1.72763256
118	Hypoplasia of the radius (HP:0002984)	1.72427425
119	Irregular epiphyses (HP:0010582)	1.72268702
120	Abnormality of abdominal situs (HP:0011620)	1.72202390
121	Abdominal situs inversus (HP:0003363)	1.72202390
122	Slender long bone (HP:0003100)	1.71228125
123	High pitched voice (HP:0001620)	1.71011521
124	Hepatic necrosis (HP:0002605)	1.70168051
125	Preaxial hand polydactyly (HP:0001177)	1.69800542
126	Abnormal spermatogenesis (HP:0008669)	1.68360488
127	Short middle phalanx of the 5th finger (HP:0004220)	1.68271711
128	Facial hemangioma (HP:0000329)	1.68151390
129	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.67417632
130	Proximal placement of thumb (HP:0009623)	1.67247659
131	Lymphoma (HP:0002665)	1.66184509
132	Cutaneous melanoma (HP:0012056)	1.64723309
133	Deviation of the thumb (HP:0009603)	1.62820099
134	Arteriovenous malformation (HP:0100026)	1.62767068
135	Basal cell carcinoma (HP:0002671)	1.60969385
136	Cholecystitis (HP:0001082)	1.59118799
137	Abnormal gallbladder physiology (HP:0012438)	1.59118799
138	Reduced antithrombin III activity (HP:0001976)	1.58434633

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	6.30276798
2	WEE1	4.56473162
3	CDC7	3.85618846
4	NEK2	3.37194761
5	EIF2AK1	3.15639767
6	VRK2	3.02108133
7	TTK	3.01313286
8	PLK4	2.99307425
9	SRPK1	2.69929173
10	BRSK2	2.44731888
11	NEK1	2.26523885
12	STK16	2.21240991
13	* PLK1	2.20787358
14	TRIM28	2.12076142
15	VRK1	1.98915314
16	ACVR1B	1.94150374
17	NME2	1.91404911
18	* AURKB	1.90385889
19	BRSK1	1.88083759
20	TLK1	1.79519812
21	CCNB1	1.68636218
22	PLK3	1.68500056
23	TESK2	1.66139720
24	CHEK2	1.64737895
25	EIF2AK3	1.62255605
26	CDK7	1.55558374
27	AURKA	1.54434286
28	TAF1	1.53291525
29	MKNK1	1.49023434
30	ATR	1.47599456
31	RPS6KA4	1.46677408
32	MAP3K8	1.45843205
33	STK4	1.39258532
34	DYRK3	1.37262916
35	STK10	1.36424615
36	RPS6KB2	1.34810609
37	ZAK	1.34731390
38	EPHA2	1.30939470
39	TSSK6	1.27065555
40	CDK4	1.22643631
41	BRAF	1.17137562
42	MKNK2	1.16664782
43	CHEK1	1.13979436
44	PBK	1.07895123
45	EIF2AK2	1.06974301
46	MELK	1.01499700
47	CDK12	0.98160382
48	PASK	0.98147158
49	CDK8	0.97983226
50	SMG1	0.96549041
51	EEF2K	0.91464705
52	PAK4	0.87571822
53	ATM	0.81498362
54	STK38L	0.81466561
55	MST1R	0.80411705
56	PDK2	0.79181097
57	PLK2	0.77493472
58	STK3	0.73174298
59	PAK1	0.72330317
60	PIM1	0.71921141
61	* CDK2	0.71396396
62	BMPR1B	0.69468901
63	KDR	0.69185993
64	* CDK1	0.62842051
65	* CSNK2A1	0.59168507
66	CLK1	0.57414104
67	BCR	0.56529149
68	LATS2	0.55045397
69	WNK3	0.54282736
70	RPS6KA5	0.53986379
71	TESK1	0.53595092
72	TGFBR1	0.53143775
73	CDK6	0.51177167
74	TNIK	0.50324741
75	CSNK2A2	0.50111808
76	SIK3	0.49910739
77	PRKCI	0.48871143
78	MAPKAPK3	0.48232673
79	DYRK2	0.48151861
80	ERBB4	0.46630756
81	ERBB3	0.45758935
82	CSNK1G3	0.45679494
83	BRD4	0.44852133
84	SCYL2	0.43791566
85	CDK18	0.43606499
86	CSNK1G1	0.42227875
87	PIM2	0.41620446
88	MET	0.40153891
89	MAP3K10	0.39841721
90	MAP4K1	0.39787170
91	NUAK1	0.37446669
92	LRRK2	0.36537492
93	MAP3K11	0.35829277
94	CDK14	0.35511116
95	MINK1	0.34024511
96	MARK3	0.33792426
97	CSNK1A1L	0.32910855
98	LIMK1	0.32785896
99	ABL2	0.32228643
100	BCKDK	0.31966483
101	PNCK	0.30945710
102	FGFR1	0.30387630
103	AKT2	0.28640392
104	NEK9	0.28136420
105	DAPK1	0.26301825
106	BLK	0.25129882
107	LATS1	0.24295277
108	ILK	0.24228130
109	IRAK4	0.23309337
110	IRAK3	0.22979404
111	MAP3K6	0.22862834
112	PRKDC	0.22557783
113	CSNK1G2	0.21927124
114	NME1	0.21857614
115	RAF1	0.21288338
116	TAOK2	0.18449609
117	MAPKAPK2	0.18428135
118	ALK	0.18017617
119	TIE1	0.17128898
120	CDK11A	0.17103757
121	MST4	0.16743766
122	UHMK1	0.16224516
123	MAPKAPK5	0.16114502
124	MAPK11	0.15571838
125	AKT1	0.15023697
126	CDK15	0.14251345
127	CSNK1E	0.13955368
128	AKT3	0.13901295
129	FLT3	0.13539911

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	4.98101293
2	Mismatch repair_Homo sapiens_hsa03430	4.27002495
3	Ribosome_Homo sapiens_hsa03010	3.41965246
4	Proteasome_Homo sapiens_hsa03050	3.40859329
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.38961012
6	Homologous recombination_Homo sapiens_hsa03440	3.38950153
7	Spliceosome_Homo sapiens_hsa03040	3.28006111
8	RNA polymerase_Homo sapiens_hsa03020	3.27939261
9	Cell cycle_Homo sapiens_hsa04110	3.22805115
10	Base excision repair_Homo sapiens_hsa03410	3.19731218
11	RNA transport_Homo sapiens_hsa03013	3.08295829
12	Nucleotide excision repair_Homo sapiens_hsa03420	2.99974648
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.71605570
14	Pyrimidine metabolism_Homo sapiens_hsa00240	2.57666329
15	One carbon pool by folate_Homo sapiens_hsa00670	2.37550879
16	Non-homologous end-joining_Homo sapiens_hsa03450	2.16783931
17	Basal transcription factors_Homo sapiens_hsa03022	2.14096968
18	RNA degradation_Homo sapiens_hsa03018	2.08716329
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.06091216
20	p53 signaling pathway_Homo sapiens_hsa04115	1.85599148
21	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.66565997
22	mRNA surveillance pathway_Homo sapiens_hsa03015	1.65849864
23	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.45822751
24	Pyruvate metabolism_Homo sapiens_hsa00620	1.40473845
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.36935184
26	Purine metabolism_Homo sapiens_hsa00230	1.36216382
27	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.35675302
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.30407467
29	Oocyte meiosis_Homo sapiens_hsa04114	1.27650337
30	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.20852897
31	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.19418051
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.14741556
33	Fatty acid elongation_Homo sapiens_hsa00062	1.09449613
34	Steroid biosynthesis_Homo sapiens_hsa00100	1.07345566
35	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.06612388
36	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.04416112
37	Propanoate metabolism_Homo sapiens_hsa00640	1.01046389
38	Herpes simplex infection_Homo sapiens_hsa05168	0.91094744
39	Viral carcinogenesis_Homo sapiens_hsa05203	0.87540368
40	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.78991563
41	Alzheimers disease_Homo sapiens_hsa05010	0.78395912
42	HTLV-I infection_Homo sapiens_hsa05166	0.75718215
43	Pentose phosphate pathway_Homo sapiens_hsa00030	0.75516385
44	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.74425840
45	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.71771121
46	Protein export_Homo sapiens_hsa03060	0.71192884
47	Folate biosynthesis_Homo sapiens_hsa00790	0.69210151
48	Antigen processing and presentation_Homo sapiens_hsa04612	0.68473441
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.68004246
50	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.67970659
51	MicroRNAs in cancer_Homo sapiens_hsa05206	0.66655097
52	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.66648559
53	Huntingtons disease_Homo sapiens_hsa05016	0.66570217
54	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.65218466
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64408125
56	Small cell lung cancer_Homo sapiens_hsa05222	0.62893856
57	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.60745370
58	Lysine degradation_Homo sapiens_hsa00310	0.54874933
59	Glutathione metabolism_Homo sapiens_hsa00480	0.54734103
60	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.49381261
61	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.46139108
62	Primary immunodeficiency_Homo sapiens_hsa05340	0.46013270
63	Selenocompound metabolism_Homo sapiens_hsa00450	0.45707137
64	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.44424848
65	Arginine and proline metabolism_Homo sapiens_hsa00330	0.42021730
66	Alcoholism_Homo sapiens_hsa05034	0.41869899
67	Parkinsons disease_Homo sapiens_hsa05012	0.39144838
68	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.37142164
69	Thyroid cancer_Homo sapiens_hsa05216	0.37006032
70	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.36678624
71	Legionellosis_Homo sapiens_hsa05134	0.36571414
72	Fatty acid metabolism_Homo sapiens_hsa01212	0.35790370
73	* Apoptosis_Homo sapiens_hsa04210	0.34666634
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.34193953
75	Sulfur relay system_Homo sapiens_hsa04122	0.33482814
76	Shigellosis_Homo sapiens_hsa05131	0.33410196
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.32175002
78	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.32162890
79	Wnt signaling pathway_Homo sapiens_hsa04310	0.31611074
80	* Hippo signaling pathway_Homo sapiens_hsa04390	0.31439474
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.30474631
82	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.28234508
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.27860079
84	Measles_Homo sapiens_hsa05162	0.27798200
85	Sulfur metabolism_Homo sapiens_hsa00920	0.27571288
86	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.27252018
87	Bladder cancer_Homo sapiens_hsa05219	0.27185952
88	Notch signaling pathway_Homo sapiens_hsa04330	0.26429294
89	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.24776329
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.23170382
91	* Hepatitis B_Homo sapiens_hsa05161	0.23091517
92	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.23078669
93	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.22278732
94	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.22113570
95	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.22106103
96	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.21971025
97	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.21725493
98	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.21452651
99	Metabolic pathways_Homo sapiens_hsa01100	0.21112602
100	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.20359803
101	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.20191811
102	Regulation of autophagy_Homo sapiens_hsa04140	0.19969402
103	Carbon metabolism_Homo sapiens_hsa01200	0.19808793
104	Influenza A_Homo sapiens_hsa05164	0.18402018
105	* Pathways in cancer_Homo sapiens_hsa05200	0.17604305
106	Oxidative phosphorylation_Homo sapiens_hsa00190	0.17585504
107	Asthma_Homo sapiens_hsa05310	0.16968009
108	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.16078708
109	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.15267708
110	Peroxisome_Homo sapiens_hsa04146	0.14986674
111	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.14347085
112	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.14315030
113	Butanoate metabolism_Homo sapiens_hsa00650	0.14122647
114	Tyrosine metabolism_Homo sapiens_hsa00350	0.13386016
115	Melanoma_Homo sapiens_hsa05218	0.13097969
116	Linoleic acid metabolism_Homo sapiens_hsa00591	0.12578853
117	* Colorectal cancer_Homo sapiens_hsa05210	0.12391490
118	FoxO signaling pathway_Homo sapiens_hsa04068	0.12215520
119	Adherens junction_Homo sapiens_hsa04520	0.12129580
120	Cardiac muscle contraction_Homo sapiens_hsa04260	0.11160578
121	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.11136503
122	Prostate cancer_Homo sapiens_hsa05215	0.11082969
123	beta-Alanine metabolism_Homo sapiens_hsa00410	0.10965485
124	Pancreatic cancer_Homo sapiens_hsa05212	0.10311840
125	Fatty acid degradation_Homo sapiens_hsa00071	0.09238621
126	Renin-angiotensin system_Homo sapiens_hsa04614	0.08604426
127	Viral myocarditis_Homo sapiens_hsa05416	0.08227307
128	Tight junction_Homo sapiens_hsa04530	0.07171702
129	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.06493777
130	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.06192594
131	Galactose metabolism_Homo sapiens_hsa00052	0.05640116

BIRC5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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