BIRC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.52696562
2mitotic sister chromatid cohesion (GO:0007064)4.94653084
3positive regulation of gamma-delta T cell activation (GO:0046645)4.87615590
4cellular response to ethanol (GO:0071361)4.70582541
5histone H3-K4 trimethylation (GO:0080182)4.67911817
6nuclear pore organization (GO:0006999)4.62794352
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.47232890
8pore complex assembly (GO:0046931)4.25135164
9cytoplasmic mRNA processing body assembly (GO:0033962)4.20579367
10regulation of DNA endoreduplication (GO:0032875)4.00988455
11histone H3-K4 methylation (GO:0051568)3.97540770
12regulation of translation, ncRNA-mediated (GO:0045974)3.94096812
13negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.94096812
14negative regulation of translation, ncRNA-mediated (GO:0040033)3.94096812
15phospholipid translocation (GO:0045332)3.92059248
16lipid translocation (GO:0034204)3.92059248
17regulation of gamma-delta T cell differentiation (GO:0045586)3.75901487
18regulation of establishment of cell polarity (GO:2000114)3.62712107
19regulation of gamma-delta T cell activation (GO:0046643)3.62014189
20establishment of protein localization to Golgi (GO:0072600)3.53284083
21protein K48-linked deubiquitination (GO:0071108)3.53011419
22regulation of pigment cell differentiation (GO:0050932)3.52904916
23nucleus localization (GO:0051647)3.51981981
24histone H3-K36 demethylation (GO:0070544)3.51381503
25peptidyl-lysine trimethylation (GO:0018023)3.49522091
26negative regulation of cell killing (GO:0031342)3.43542714
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.43542714
28Golgi to endosome transport (GO:0006895)3.43500789
29positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.39019938
30positive T cell selection (GO:0043368)3.35793929
31regulation of RNA export from nucleus (GO:0046831)3.34463132
32positive regulation of developmental pigmentation (GO:0048087)3.32982699
33negative T cell selection (GO:0043383)3.32771290
34prenylation (GO:0097354)3.32459008
35protein prenylation (GO:0018342)3.32459008
36peptidyl-lysine dimethylation (GO:0018027)3.25441086
37phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.18496919
38embryonic process involved in female pregnancy (GO:0060136)3.17571399
39pre-miRNA processing (GO:0031054)3.15785743
40histone lysine methylation (GO:0034968)3.15734260
41regulation of protein polyubiquitination (GO:1902914)3.14901828
42establishment of nucleus localization (GO:0040023)3.14612534
43protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)3.14557526
44protein targeting to Golgi (GO:0000042)3.14051073
45histone mRNA catabolic process (GO:0071044)3.12823925
46positive thymic T cell selection (GO:0045059)3.11070032
47negative thymic T cell selection (GO:0045060)3.10544360
48glucocorticoid receptor signaling pathway (GO:0042921)3.08470090
49NLS-bearing protein import into nucleus (GO:0006607)3.08333086
50pericardium development (GO:0060039)3.08175473
51histone H3-K9 demethylation (GO:0033169)3.06536867
52hepatocyte apoptotic process (GO:0097284)3.04522219
53regulation of histone H3-K9 methylation (GO:0051570)3.04480377
54regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.04180814
55negative regulation of histone methylation (GO:0031061)3.02980526
56regulation of establishment or maintenance of cell polarity (GO:0032878)2.98918255
57positive regulation of granulocyte differentiation (GO:0030854)2.98872468
58histone lysine demethylation (GO:0070076)2.96798820
59protein targeting to vacuole (GO:0006623)2.91522109
60protein targeting to lysosome (GO:0006622)2.91522109
61establishment of protein localization to vacuole (GO:0072666)2.91522109
62histone-serine phosphorylation (GO:0035404)2.87900050
63peptidyl-threonine phosphorylation (GO:0018107)2.87237082
64peptidyl-lysine methylation (GO:0018022)2.86491567
65T cell selection (GO:0045058)2.85287479
66histone demethylation (GO:0016577)2.85259020
67regulation of mRNA catabolic process (GO:0061013)2.83303073
68dosage compensation (GO:0007549)2.80910413
69corticosteroid receptor signaling pathway (GO:0031958)2.80062472
70COPII vesicle coating (GO:0048208)2.79218183
71regulation of nucleobase-containing compound transport (GO:0032239)2.78142258
72genitalia morphogenesis (GO:0035112)2.76802028
73B cell receptor signaling pathway (GO:0050853)2.76322918
74peptidyl-threonine modification (GO:0018210)2.76124493
75interferon-gamma production (GO:0032609)2.73663958
76oocyte development (GO:0048599)2.70825354
77microtubule anchoring (GO:0034453)2.68775953
78mitotic chromosome condensation (GO:0007076)2.66210534
79histone H3-K9 methylation (GO:0051567)2.64752379
80positive regulation of histone deacetylation (GO:0031065)2.64734332
81DNA geometric change (GO:0032392)2.64174253
82positive regulation of natural killer cell differentiation (GO:0032825)2.63055202
83DNA duplex unwinding (GO:0032508)2.61428221
84positive regulation of mRNA catabolic process (GO:0061014)2.61409689
85sister chromatid cohesion (GO:0007062)2.60785128
86regulation of interleukin-12 biosynthetic process (GO:0045075)2.60328336
87snRNA transcription (GO:0009301)2.60067273
88thymic T cell selection (GO:0045061)2.59343468
89positive regulation of mitotic sister chromatid separation (GO:1901970)2.58788776
90positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.58788776
91positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.58788776
92monoubiquitinated protein deubiquitination (GO:0035520)2.58592668
93translesion synthesis (GO:0019985)2.57111777
94regulation of sister chromatid cohesion (GO:0007063)2.56548174
95negative regulation of DNA-dependent DNA replication (GO:2000104)2.56386611
96histone methylation (GO:0016571)2.55373871
97insulin-like growth factor receptor signaling pathway (GO:0048009)2.53985096
98protein K11-linked deubiquitination (GO:0035871)2.53781155
99peptidyl-serine phosphorylation (GO:0018105)2.52950235
100interkinetic nuclear migration (GO:0022027)2.51084209
101regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.50407356
102positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.50407356
103positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.50354874
104regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.50354874
105B cell homeostasis (GO:0001782)2.49286223
106embryonic retina morphogenesis in camera-type eye (GO:0060059)2.48420095
107response to interleukin-15 (GO:0070672)2.47845873
108early endosome to late endosome transport (GO:0045022)2.47694124
109positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.47685299
110regulation of transforming growth factor beta2 production (GO:0032909)2.47291219
111phosphatidylinositol phosphorylation (GO:0046854)2.46875063
112coronary vasculature morphogenesis (GO:0060977)2.46260343
113negative regulation of DNA repair (GO:0045738)2.45549120
114histone H3-K9 modification (GO:0061647)2.45526490
115nucleus organization (GO:0006997)2.45382743
116protein demethylation (GO:0006482)2.44175991
117protein dealkylation (GO:0008214)2.44175991
118regulation of mitotic spindle organization (GO:0060236)2.42809216
119regulation of histone methylation (GO:0031060)2.42219342
120negative regulation of granulocyte differentiation (GO:0030853)2.41564226
121positive regulation of B cell differentiation (GO:0045579)2.41211439
122TOR signaling (GO:0031929)2.41173464
123positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.40559009
124stress granule assembly (GO:0034063)2.40433373
125regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.38858164
126retrograde transport, vesicle recycling within Golgi (GO:0000301)2.37849932
127embryonic camera-type eye morphogenesis (GO:0048596)2.37836244
128definitive hemopoiesis (GO:0060216)2.37495300
129Golgi organization (GO:0007030)2.37261314
130centrosome localization (GO:0051642)2.36348550
131regulation of histone H3-K4 methylation (GO:0051569)2.35024320
132response to UV-C (GO:0010225)2.34421500
133CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.34242891
134T-helper cell differentiation (GO:0042093)2.34242891
135protein K63-linked deubiquitination (GO:0070536)2.33400425
136negative regulation of neurotransmitter secretion (GO:0046929)2.32958213
137striated muscle atrophy (GO:0014891)2.32888455
138positive regulation of DNA-templated transcription, initiation (GO:2000144)2.32129567
139sister chromatid segregation (GO:0000819)2.31788092
140regulation of skeletal muscle cell differentiation (GO:2001014)2.30923139
141histone H4-K16 acetylation (GO:0043984)2.30895066
142regulation of B cell differentiation (GO:0045577)2.30245434
143regulation of membrane lipid distribution (GO:0097035)2.30241839
144CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.27503628
145regulation of histone H3-K27 methylation (GO:0061085)2.26928329
146negative regulation of B cell proliferation (GO:0030889)2.26702402
147replicative senescence (GO:0090399)2.26348443
148positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.24598981
149JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.24290705
150regulation of B cell receptor signaling pathway (GO:0050855)2.24000965
151I-kappaB phosphorylation (GO:0007252)2.21534268

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.48871826
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.53864974
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.41030317
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.84469495
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.69438357
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.39044419
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.34955921
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.28543183
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.00231594
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.85579336
11GATA1_22025678_ChIP-Seq_K562_Human2.63734346
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59121958
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.55789370
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46861379
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.21539379
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07737275
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04596282
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02321818
19RUNX_20019798_ChIP-Seq_JUKART_Human2.02240391
20MYC_22102868_ChIP-Seq_BL_Human1.91876721
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80670803
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77268832
23GBX2_23144817_ChIP-Seq_PC3_Human1.75587794
24AR_21572438_ChIP-Seq_LNCaP_Human1.73747453
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70594959
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.65372235
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.65327367
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63954828
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62410199
30MYB_26560356_Chip-Seq_TH1_Human1.60803557
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57149548
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56910148
33MYB_26560356_Chip-Seq_TH2_Human1.54047370
34RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.53827513
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51870960
36TP53_16413492_ChIP-PET_HCT116_Human1.51226143
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.48329510
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.46751212
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46495303
40SMAD4_21799915_ChIP-Seq_A2780_Human1.46394262
41TAF15_26573619_Chip-Seq_HEK293_Human1.45857716
42FOXM1_26456572_ChIP-Seq_MCF-7_Human1.45536912
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45262106
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44907402
45FUS_26573619_Chip-Seq_HEK293_Human1.41936434
46FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.41852939
47* TCF7_22412390_ChIP-Seq_EML_Mouse1.40884039
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39486975
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38487193
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37153288
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36028322
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35696741
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35573796
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34386204
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31895638
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31285290
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30974394
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28806969
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28806969
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26930656
61* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26697299
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26672741
63IRF8_27001747_Chip-Seq_BMDM_Mouse1.26635652
64IGF1R_20145208_ChIP-Seq_DFB_Human1.26092625
65PKCTHETA_26484144_Chip-Seq_BREAST_Human1.25545574
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23698246
67* BRD4_25478319_ChIP-Seq_HGPS_Human1.23465250
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23301927
69ER_23166858_ChIP-Seq_MCF-7_Human1.22881021
70SCL_19346495_ChIP-Seq_HPC-7_Human1.22274622
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.21407197
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.20286700
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19573008
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.19499998
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18827774
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17341117
77SPI1_23127762_ChIP-Seq_K562_Human1.16321207
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14570749
79TCF4_18268006_ChIP-ChIP_LS174T_Human1.13953554
80CIITA_25753668_ChIP-Seq_RAJI_Human1.12954591
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11438894
82MAF_26560356_Chip-Seq_TH1_Human1.10415801
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10374573
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09060245
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08699773
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.07290346
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07190594
88AHR_22903824_ChIP-Seq_MCF-7_Human1.07178181
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.06850678
90PU_27001747_Chip-Seq_BMDM_Mouse1.06731711
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06064249
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.05910949
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05597576
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05597576
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05595897
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.04577098
97PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04286203
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03631040
99* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03467497
100UTX_26944678_Chip-Seq_JUKART_Human1.03262272
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01735771
102P300_19829295_ChIP-Seq_ESCs_Human1.01459171
103VDR_21846776_ChIP-Seq_THP-1_Human1.01390782
104* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00898271
105FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99915083
106GATA3_27048872_Chip-Seq_THYMUS_Human0.99557289
107TP63_23658742_ChIP-Seq_EP156T_Human0.99525964
108FLI1_21867929_ChIP-Seq_TH2_Mouse0.98857001
109SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98632742
110OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98066334
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98051800
112WT1_19549856_ChIP-ChIP_CCG9911_Human0.97779685
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97233479
114ARNT_22903824_ChIP-Seq_MCF-7_Human0.96466365
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95988705
116P53_22387025_ChIP-Seq_ESCs_Mouse0.94874555
117* STAT3_23295773_ChIP-Seq_U87_Human0.94572375
118VDR_24787735_ChIP-Seq_THP-1_Human0.92952549
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.92815362
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.91322657
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90705627
122* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90570435
123TCF4_23295773_ChIP-Seq_U87_Human0.90524505
124CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90122194
125IRF8_21731497_ChIP-ChIP_J774_Mouse0.89187936
126VDR_24763502_ChIP-Seq_THP-1_Human0.88751739
127NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86716500
128* EWS_26573619_Chip-Seq_HEK293_Human0.85836635
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81480396
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81039617
131* FOXA2_19822575_ChIP-Seq_HepG2_Human0.80437228
132PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80408710
133TBX3_20139965_ChIP-Seq_ESCs_Mouse0.78561661
134FLI1_27457419_Chip-Seq_LIVER_Mouse0.78225386
135SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.77947427
136* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77597794
137KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77337373
138TBX3_20139965_ChIP-Seq_MESCs_Mouse0.76922451
139PIAS1_25552417_ChIP-Seq_VCAP_Human0.76460856
140RUNX1_22412390_ChIP-Seq_EML_Mouse0.76277415
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.75977398
142SOX9_24532713_ChIP-Seq_HFSC_Mouse0.75952836

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.70654853
2MP0002166_altered_tumor_susceptibility3.34543037
3MP0003300_gastrointestinal_ulcer3.08446630
4MP0005076_abnormal_cell_differentiation2.74616284
5MP0010352_gastrointestinal_tract_polyps2.70834625
6MP0002006_tumorigenesis2.67254943
7MP0003787_abnormal_imprinting2.61844707
8MP0002396_abnormal_hematopoietic_system2.57783666
9MP0002009_preneoplasia2.54087853
10MP0010307_abnormal_tumor_latency2.47671545
11MP0004808_abnormal_hematopoietic_stem2.27014609
12MP0003763_abnormal_thymus_physiology2.23990598
13MP0008057_abnormal_DNA_replication2.22656220
14MP0000015_abnormal_ear_pigmentation2.06206072
15MP0005174_abnormal_tail_pigmentation2.03980594
16MP0010094_abnormal_chromosome_stability2.01954184
17MP0000371_diluted_coat_color1.88136874
18MP0005409_darkened_coat_color1.86152356
19MP0003045_fibrosis1.79266467
20MP0001835_abnormal_antigen_presentation1.72691105
21MP0003121_genomic_imprinting1.67680953
22MP0001873_stomach_inflammation1.65944209
23MP0001800_abnormal_humoral_immune1.62433127
24MP0002877_abnormal_melanocyte_morpholog1.60587016
25MP0003950_abnormal_plasma_membrane1.58110419
26MP0003868_abnormal_feces_composition1.57175681
27MP0000703_abnormal_thymus_morphology1.56414859
28MP0009278_abnormal_bone_marrow1.54660324
29MP0003111_abnormal_nucleus_morphology1.47175709
30MP0001661_extended_life_span1.46503588
31MP0003183_abnormal_peptide_metabolism1.46255451
32MP0002398_abnormal_bone_marrow1.45961444
33MP0005671_abnormal_response_to1.45157584
34MP0003566_abnormal_cell_adhesion1.42707332
35MP0008877_abnormal_DNA_methylation1.41713117
36MP0004381_abnormal_hair_follicle1.38300232
37MP0010234_abnormal_vibrissa_follicle1.37862234
38MP0002095_abnormal_skin_pigmentation1.37853984
39MP0003091_abnormal_cell_migration1.34112652
40MP0001790_abnormal_immune_system1.33612699
41MP0005387_immune_system_phenotype1.33612699
42MP0002452_abnormal_antigen_presenting1.28051751
43MP0003890_abnormal_embryonic-extraembry1.26948605
44MP0006054_spinal_hemorrhage1.25343734
45MP0001545_abnormal_hematopoietic_system1.20998887
46MP0005397_hematopoietic_system_phenotyp1.20998887
47MP0003828_pulmonary_edema1.20468459
48MP0002420_abnormal_adaptive_immunity1.20385376
49MP0009697_abnormal_copulation1.20047237
50MP0000383_abnormal_hair_follicle1.19829507
51MP0001819_abnormal_immune_cell1.19328350
52MP0004084_abnormal_cardiac_muscle1.19203524
53MP0010155_abnormal_intestine_physiology1.18383769
54MP0008058_abnormal_DNA_repair1.16948480
55* MP0003077_abnormal_cell_cycle1.15051452
56MP0002075_abnormal_coat/hair_pigmentati1.14624028
57MP0005451_abnormal_body_composition1.13633291
58MP0000685_abnormal_immune_system1.11946539
59MP0002723_abnormal_immune_serum1.11665886
60MP0004134_abnormal_chest_morphology1.09501752
61* MP0001915_intracranial_hemorrhage1.08930890
62MP0000716_abnormal_immune_system1.08921131
63MP0002722_abnormal_immune_system1.08044034
64MP0002088_abnormal_embryonic_growth/wei1.08005528
65MP0000689_abnormal_spleen_morphology1.07821943
66MP0000427_abnormal_hair_cycle1.07699805
67MP0009703_decreased_birth_body1.07627210
68MP0003984_embryonic_growth_retardation1.07504115
69MP0005187_abnormal_penis_morphology1.05927215
70MP0001879_abnormal_lymphatic_vessel1.05750724
71MP0010678_abnormal_skin_adnexa1.04792086
72* MP0002086_abnormal_extraembryonic_tissu1.04464925
73MP0004947_skin_inflammation1.03877382
74MP0003941_abnormal_skin_development1.03692746
75MP0004264_abnormal_extraembryonic_tissu1.03449872
76MP0000733_abnormal_muscle_development1.03287086
77MP0005275_abnormal_skin_tensile1.02769984
78MP0003866_abnormal_defecation1.02357643
79MP0002928_abnormal_bile_duct1.01611764
80MP0008007_abnormal_cellular_replicative1.01345020
81MP0003705_abnormal_hypodermis_morpholog1.01296309
82MP0005380_embryogenesis_phenotype1.00931350
83MP0001672_abnormal_embryogenesis/_devel1.00931350
84MP0005220_abnormal_exocrine_pancreas1.00275382
85MP0004036_abnormal_muscle_relaxation0.99711769
86MP0004185_abnormal_adipocyte_glucose0.98288751
87* MP0000350_abnormal_cell_proliferation0.98283171
88* MP0004197_abnormal_fetal_growth/weight/0.98192862
89MP0003943_abnormal_hepatobiliary_system0.95972845
90MP0003656_abnormal_erythrocyte_physiolo0.95191666
91MP0005000_abnormal_immune_tolerance0.92786175
92MP0001186_pigmentation_phenotype0.89556163
93MP0003935_abnormal_craniofacial_develop0.88635732
94MP0003221_abnormal_cardiomyocyte_apopto0.87411740
95MP0009115_abnormal_fat_cell0.86898201
96MP0001299_abnormal_eye_distance/0.86526662
97MP0005310_abnormal_salivary_gland0.86310619
98MP0003453_abnormal_keratinocyte_physiol0.86070216
99MP0003632_abnormal_nervous_system0.86060929
100MP0000490_abnormal_crypts_of0.85296243
101MP0000465_gastrointestinal_hemorrhage0.85207271
102MP0005621_abnormal_cell_physiology0.85135840
103MP0001851_eye_inflammation0.84513963
104* MP0002429_abnormal_blood_cell0.84394541
105MP0002405_respiratory_system_inflammati0.84248381
106MP0005023_abnormal_wound_healing0.83659485
107MP0003436_decreased_susceptibility_to0.83221792
108MP0004484_altered_response_of0.83085889
109MP0003115_abnormal_respiratory_system0.82823167
110MP0002084_abnormal_developmental_patter0.80463506
111MP0004130_abnormal_muscle_cell0.79353277
112MP0008961_abnormal_basal_metabolism0.79345970
113MP0004233_abnormal_muscle_weight0.76101563
114* MP0002925_abnormal_cardiovascular_devel0.75892782
115MP0002019_abnormal_tumor_incidence0.75364533
116MP0003303_peritoneal_inflammation0.75178753
117MP0003693_abnormal_embryo_hatching0.75113211
118MP0005408_hypopigmentation0.74228368
119MP0008438_abnormal_cutaneous_collagen0.73359914
120MP0002168_other_aberrant_phenotype0.72066842
121MP0002419_abnormal_innate_immunity0.71813782
122MP0000428_abnormal_craniofacial_morphol0.71480942
123MP0010630_abnormal_cardiac_muscle0.70991436
124MP0000432_abnormal_head_morphology0.70936048
125MP0005075_abnormal_melanosome_morpholog0.70914996
126MP0000627_abnormal_mammary_gland0.70745604
127MP0000377_abnormal_hair_follicle0.70300250
128MP0003172_abnormal_lysosome_physiology0.69758379
129MP0009780_abnormal_chondrocyte_physiolo0.68795900
130MP0002332_abnormal_exercise_endurance0.68567185
131MP0010368_abnormal_lymphatic_system0.67923753
132MP0001730_embryonic_growth_arrest0.66351796
133MP0001697_abnormal_embryo_size0.65866664
134MP0002269_muscular_atrophy0.65712245
135MP0003448_altered_tumor_morphology0.65443597
136MP0005384_cellular_phenotype0.64962013
137MP0009672_abnormal_birth_weight0.64693628
138MP0000013_abnormal_adipose_tissue0.64114745
139MP0002108_abnormal_muscle_morphology0.62683432
140MP0003937_abnormal_limbs/digits/tail_de0.61992595
141* MP0001784_abnormal_fluid_regulation0.60996165

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)5.14190402
2Volvulus (HP:0002580)3.52096655
3Absent frontal sinuses (HP:0002688)3.23101702
4Macroorchidism (HP:0000053)3.16392169
5Long eyelashes (HP:0000527)3.00190411
6Short 4th metacarpal (HP:0010044)2.92387441
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.92387441
8T lymphocytopenia (HP:0005403)2.91199269
9Abnormality of the nasal septum (HP:0000419)2.78921629
10Narrow palate (HP:0000189)2.77655919
11Colitis (HP:0002583)2.76660490
12Lip pit (HP:0100267)2.76424370
13Truncal obesity (HP:0001956)2.73485187
14Abnormality of T cell number (HP:0011839)2.67884734
15Urethral obstruction (HP:0000796)2.67217730
16Overgrowth (HP:0001548)2.63042004
17Dysmetric saccades (HP:0000641)2.61047349
18Chromsome breakage (HP:0040012)2.59876861
19Short chin (HP:0000331)2.56925633
20Ectopic kidney (HP:0000086)2.56420487
21Acute myeloid leukemia (HP:0004808)2.55134000
22Thyroid carcinoma (HP:0002890)2.52254472
23Thyroiditis (HP:0100646)2.48631672
24Deep philtrum (HP:0002002)2.48263123
25Neonatal hypoglycemia (HP:0001998)2.44916023
26Recurrent viral infections (HP:0004429)2.38957674
27Heterotopia (HP:0002282)2.36852849
28Fair hair (HP:0002286)2.35913369
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34529302
30Anal stenosis (HP:0002025)2.29623868
31Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.26296060
32Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.24897623
33Subacute progressive viral hepatitis (HP:0006572)2.20039861
34Viral hepatitis (HP:0006562)2.19726054
35Prominent nose (HP:0000448)2.18100086
36Menstrual irregularities (HP:0000858)2.17673392
37Spinal cord lesions (HP:0100561)2.12660372
38Syringomyelia (HP:0003396)2.12660372
39Recurrent fungal infections (HP:0002841)2.12274617
40IgA deficiency (HP:0002720)2.08438306
41IgM deficiency (HP:0002850)2.06692820
42Periodontitis (HP:0000704)2.06250988
43Abnormality of chromosome stability (HP:0003220)2.05598954
44Abnormality of the epiphyses of the hand (HP:0005924)2.04593100
45Acute lymphatic leukemia (HP:0006721)2.03683003
46Chronic diarrhea (HP:0002028)2.02904283
47Hypoplasia of the thymus (HP:0000778)2.02542418
48Aortic aneurysm (HP:0004942)2.00579245
49Trigonocephaly (HP:0000243)1.99319322
50Aqueductal stenosis (HP:0002410)1.98839077
51Nephroblastoma (Wilms tumor) (HP:0002667)1.98002504
52Scanning speech (HP:0002168)1.97985577
53Sparse lateral eyebrow (HP:0005338)1.97744419
54Curly hair (HP:0002212)1.97050596
55Thick eyebrow (HP:0000574)1.95725001
56Smooth philtrum (HP:0000319)1.95066583
57Relative macrocephaly (HP:0004482)1.93716241
58Rhabdomyosarcoma (HP:0002859)1.93393201
59Germ cell neoplasia (HP:0100728)1.92979801
60Obsessive-compulsive behavior (HP:0000722)1.92554479
61Generalized hypopigmentation of hair (HP:0011358)1.92338518
62Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.91085622
63Neoplasm of the adrenal cortex (HP:0100641)1.90820187
64Abnormality of the frontal sinuses (HP:0002687)1.90205913
65Bladder neoplasm (HP:0009725)1.89944030
66Cubitus valgus (HP:0002967)1.89704655
67Medulloblastoma (HP:0002885)1.89385125
68Embryonal renal neoplasm (HP:0011794)1.89373994
69Ureteral obstruction (HP:0006000)1.88130715
70Abnormality of the astrocytes (HP:0100707)1.86897561
71Astrocytoma (HP:0009592)1.86897561
72Asymmetry of the thorax (HP:0001555)1.86643120
73Genetic anticipation (HP:0003743)1.86239731
74Autoimmune hemolytic anemia (HP:0001890)1.85943579
75Limited elbow extension (HP:0001377)1.85905111
76Hepatoblastoma (HP:0002884)1.82951973
77Flat acetabular roof (HP:0003180)1.82939257
78Conjunctival telangiectasia (HP:0000524)1.82015972
79Thoracolumbar scoliosis (HP:0002944)1.81821466
80Hematochezia (HP:0002573)1.81808545
81Skull defect (HP:0001362)1.79074582
82Abnormal glucose tolerance (HP:0001952)1.78549559
83Cystic hygroma (HP:0000476)1.78547301
84Glioma (HP:0009733)1.78533102
85Biliary tract neoplasm (HP:0100574)1.77756747
86Vertebral arch anomaly (HP:0008438)1.77717481
87Difficulty running (HP:0009046)1.77670016
88Spondylolisthesis (HP:0003302)1.77370604
89Abnormality of the 4th metacarpal (HP:0010012)1.75896889
90Persistence of primary teeth (HP:0006335)1.75622609
91Mitral valve prolapse (HP:0001634)1.75355838
92Papillary thyroid carcinoma (HP:0002895)1.75299439
93Widely spaced teeth (HP:0000687)1.74642880
94Chronic hepatic failure (HP:0100626)1.73950483
95Cerebral aneurysm (HP:0004944)1.73765630
96Cutis marmorata (HP:0000965)1.73638590
97Neoplasm of the small intestine (HP:0100833)1.73296191
98Coarse hair (HP:0002208)1.73225718
99Severe combined immunodeficiency (HP:0004430)1.72651817
100Ankyloglossia (HP:0010296)1.72282615
101Depressed nasal tip (HP:0000437)1.72028385
102Dislocated radial head (HP:0003083)1.71969500
103Spontaneous hematomas (HP:0007420)1.71815246
104Ureteral stenosis (HP:0000071)1.71638338
105Broad thumb (HP:0011304)1.71439014
106Abnormal pancreas size (HP:0012094)1.71037177
107Low anterior hairline (HP:0000294)1.70724209
108Sandal gap (HP:0001852)1.70132724
109Overlapping toe (HP:0001845)1.69610314
110Hyperkalemia (HP:0002153)1.69589896
111Transitional cell carcinoma of the bladder (HP:0006740)1.69568701
112Hypoplasia of the maxilla (HP:0000327)1.69481049
113Abnormal delayed hypersensitivity skin test (HP:0002963)1.68997173
114Autoimmune thrombocytopenia (HP:0001973)1.68626765
115Midline defect of the nose (HP:0004122)1.68589266
116Leiomyosarcoma (HP:0100243)1.68095286
117Uterine leiomyosarcoma (HP:0002891)1.68095286
118Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.66825040
119Tapered finger (HP:0001182)1.66445840
120Hypoplastic labia majora (HP:0000059)1.66294945
121Neoplasm of the oral cavity (HP:0100649)1.65887146
122Hypoplastic ischia (HP:0003175)1.65613378
123Abnormal hair whorl (HP:0010721)1.65476411
124Increased density of long bones (HP:0006392)1.65220122
125Prostate neoplasm (HP:0100787)1.64692257
126B lymphocytopenia (HP:0010976)1.62772717
127Abnormality of B cell number (HP:0010975)1.62772717
128Progressive hearing impairment (HP:0001730)1.61520454
129Impulsivity (HP:0100710)1.61369056
130Chronic mucocutaneous candidiasis (HP:0002728)1.60995625
131Recurrent cutaneous fungal infections (HP:0011370)1.60995625
132Abnormality of the columella (HP:0009929)1.60317482
133Panhypogammaglobulinemia (HP:0003139)1.60267694
134Myelodysplasia (HP:0002863)1.59960395
135Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.59783624
136Malignant gastrointestinal tract tumors (HP:0006749)1.59231296
137Gastrointestinal carcinoma (HP:0002672)1.59231296
138Submucous cleft hard palate (HP:0000176)1.58693550
139Deviation of the thumb (HP:0009603)1.57932709
140Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.57166632
141Abnormality of the radial head (HP:0003995)1.56039970
142Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.54582929
143Cafe-au-lait spot (HP:0000957)1.53456938
144Long clavicles (HP:0000890)1.52580520
145Large earlobe (HP:0009748)1.52342071
146Osteolytic defects of the hand bones (HP:0009699)1.51859480
147Osteolytic defects of the phalanges of the hand (HP:0009771)1.51859480
148Abnormality of the ischium (HP:0003174)1.51757228
149High pitched voice (HP:0001620)1.51234903
150Bladder carcinoma (HP:0002862)1.51035300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.11210149
2CAMK1D3.01351863
3BRD42.58443988
4CAMK1G2.50920515
5FRK2.49466355
6FGFR32.22214766
7JAK32.20953271
8LATS12.19184570
9MAP3K142.01879074
10SGK21.97893132
11ACVR1B1.96771806
12NUAK11.92766053
13MAP4K11.89880133
14INSRR1.88632143
15TXK1.88328099
16ZAK1.88204200
17JAK11.84491275
18SGK31.78750061
19PIK3CG1.62225052
20CDC71.59060823
21MAP3K21.49950291
22EPHA31.45901528
23AKT31.43907742
24TTN1.43042134
25TAOK31.39944663
26EEF2K1.37888499
27FGFR21.37125606
28MAP3K101.35495123
29CHUK1.34174010
30SCYL21.34080365
31ATR1.32890648
32SIK11.29225114
33CAMKK21.27915018
34STK31.22083505
35OBSCN1.21945163
36CDK61.19657010
37ITK1.19081661
38TYK21.17344197
39MELK1.16968475
40MTOR1.13571691
41RET1.12768483
42BLK1.12538566
43MKNK21.10350483
44PIM11.10328706
45TRPM71.09147060
46STK41.06136050
47FGFR41.05414929
48MAP2K31.04740462
49PDGFRB1.04348901
50EIF2AK31.04322855
51ATM1.02371936
52SRPK10.96624924
53STK100.95654798
54CDK90.95255118
55STK390.94954132
56ICK0.94797507
57PTK60.93874250
58TEC0.92525397
59BRSK20.92514446
60CSF1R0.90872751
61NLK0.90439466
62NEK60.90050658
63NEK90.87553976
64MAP3K70.87537339
65YES10.87168745
66NEK20.85094369
67MARK20.82337055
68CDK40.81324594
69RPS6KB10.80992763
70PRKAA20.80408947
71MAP3K60.79723002
72BMPR1B0.79393317
73SGK10.79356759
74HCK0.77495859
75IKBKE0.77195147
76CHEK10.76582671
77LCK0.76331168
78CASK0.75985389
79STK38L0.75575948
80PRKCH0.73910652
81MKNK10.73446996
82EIF2AK20.72905485
83SIK20.72637525
84MAP3K40.72351082
85SGK2230.71880157
86SGK4940.71880157
87HIPK20.71777103
88WNK10.71530179
89DMPK0.71522303
90JAK20.70926158
91MARK30.70168010
92FER0.69608008
93MAPK110.69306598
94RIPK10.68847885
95MAP3K130.67674481
96MST1R0.66466638
97KIT0.65967256
98IKBKB0.65254291
99CAMK40.63984029
100BMPR20.63531598
101TRIB30.63183181
102FLT30.63087432
103PDGFRA0.61837831
104TLK10.61495408
105PASK0.60169817
106BTK0.59422265
107CDC42BPA0.59367968
108CSK0.58453303
109IRAK40.57477497
110ZAP700.56897148
111RPS6KB20.55866520
112MAPK140.55117494
113CDK20.54881076
114AURKB0.53525639
115CLK10.52537439
116PRKDC0.52446662
117CHEK20.52238445
118EGFR0.50736024
119FGFR10.49972424
120DYRK1A0.49323798
121AKT10.49217470
122PRPF4B0.48729047
123PRKCQ0.48567148
124RPS6KA40.48548532
125STK380.48263424
126CDK10.48131619
127SYK0.47970620
128PDK10.47360419
129KSR10.47126647
130CSNK1D0.46705413
131PIK3CA0.46342032
132PKN20.46185110
133MET0.44675753
134TAOK10.44073189
135ERBB20.44042953
136PRKAA10.43499120
137STK240.42470891
138MAPK100.41707848
139STK110.40543977
140ERBB30.39786588

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.09488153
2Primary immunodeficiency_Homo sapiens_hsa053402.06861599
3NF-kappa B signaling pathway_Homo sapiens_hsa040641.89696576
4Non-homologous end-joining_Homo sapiens_hsa034501.78248561
5Systemic lupus erythematosus_Homo sapiens_hsa053221.65481793
6T cell receptor signaling pathway_Homo sapiens_hsa046601.60304409
7Measles_Homo sapiens_hsa051621.56774146
8MicroRNAs in cancer_Homo sapiens_hsa052061.52441529
9B cell receptor signaling pathway_Homo sapiens_hsa046621.49301964
10Chronic myeloid leukemia_Homo sapiens_hsa052201.45628403
11Transcriptional misregulation in cancer_Homo sapiens_hsa052021.44330915
12Type II diabetes mellitus_Homo sapiens_hsa049301.40753605
13Small cell lung cancer_Homo sapiens_hsa052221.38294329
14Thyroid cancer_Homo sapiens_hsa052161.37911941
15Phosphatidylinositol signaling system_Homo sapiens_hsa040701.37131780
16Fanconi anemia pathway_Homo sapiens_hsa034601.33696033
17Viral carcinogenesis_Homo sapiens_hsa052031.32896057
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32795486
19Adherens junction_Homo sapiens_hsa045201.30930556
20Prostate cancer_Homo sapiens_hsa052151.30896979
21Renal cell carcinoma_Homo sapiens_hsa052111.28402299
22mTOR signaling pathway_Homo sapiens_hsa041501.27483054
23Osteoclast differentiation_Homo sapiens_hsa043801.25437498
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23966573
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20298698
26Antigen processing and presentation_Homo sapiens_hsa046121.20065223
27Acute myeloid leukemia_Homo sapiens_hsa052211.19938178
28One carbon pool by folate_Homo sapiens_hsa006701.19372794
29Hematopoietic cell lineage_Homo sapiens_hsa046401.18954950
30Hepatitis B_Homo sapiens_hsa051611.17437499
31Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17190099
32Herpes simplex infection_Homo sapiens_hsa051681.17083327
33Endometrial cancer_Homo sapiens_hsa052131.16607976
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.15678193
35Inositol phosphate metabolism_Homo sapiens_hsa005621.15368024
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.15353674
37Influenza A_Homo sapiens_hsa051641.12728187
38Toxoplasmosis_Homo sapiens_hsa051451.11867470
39Pancreatic cancer_Homo sapiens_hsa052121.09364237
40HTLV-I infection_Homo sapiens_hsa051661.08862990
41Cell cycle_Homo sapiens_hsa041101.07489569
42Circadian rhythm_Homo sapiens_hsa047101.06972023
43Viral myocarditis_Homo sapiens_hsa054161.06957297
44Leishmaniasis_Homo sapiens_hsa051401.06005361
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05928050
46Non-small cell lung cancer_Homo sapiens_hsa052231.02009732
47FoxO signaling pathway_Homo sapiens_hsa040681.01856502
48TNF signaling pathway_Homo sapiens_hsa046681.00436291
49Insulin resistance_Homo sapiens_hsa049310.99852449
50Colorectal cancer_Homo sapiens_hsa052100.97910177
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93384521
52Prolactin signaling pathway_Homo sapiens_hsa049170.93144579
53Proteoglycans in cancer_Homo sapiens_hsa052050.93026274
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.92994216
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91297746
56Platelet activation_Homo sapiens_hsa046110.89547345
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.89115274
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.88527795
59mRNA surveillance pathway_Homo sapiens_hsa030150.88101565
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87588585
61Focal adhesion_Homo sapiens_hsa045100.86571433
62Fatty acid biosynthesis_Homo sapiens_hsa000610.85272298
63Chemokine signaling pathway_Homo sapiens_hsa040620.85255635
64Apoptosis_Homo sapiens_hsa042100.83872075
65GnRH signaling pathway_Homo sapiens_hsa049120.83647293
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83196137
67Long-term potentiation_Homo sapiens_hsa047200.82833890
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82516680
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81943299
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81245835
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81022312
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79317869
73VEGF signaling pathway_Homo sapiens_hsa043700.78087922
74* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77755400
75Dorso-ventral axis formation_Homo sapiens_hsa043200.77221845
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75769980
77Glioma_Homo sapiens_hsa052140.74813261
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74401902
79Estrogen signaling pathway_Homo sapiens_hsa049150.73297916
80Hepatitis C_Homo sapiens_hsa051600.72956740
81ErbB signaling pathway_Homo sapiens_hsa040120.72413342
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.71250633
83Alcoholism_Homo sapiens_hsa050340.71202545
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71069550
85Pathways in cancer_Homo sapiens_hsa052000.68669750
86Notch signaling pathway_Homo sapiens_hsa043300.67947225
87p53 signaling pathway_Homo sapiens_hsa041150.67937129
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67415207
89Allograft rejection_Homo sapiens_hsa053300.67109147
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66310209
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66112889
92ECM-receptor interaction_Homo sapiens_hsa045120.65911705
93Graft-versus-host disease_Homo sapiens_hsa053320.64425127
94Epstein-Barr virus infection_Homo sapiens_hsa051690.62722317
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62389754
96Amoebiasis_Homo sapiens_hsa051460.62096076
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61351311
98Mismatch repair_Homo sapiens_hsa034300.59946558
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.59449645
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59349839
101MAPK signaling pathway_Homo sapiens_hsa040100.58809359
102Tuberculosis_Homo sapiens_hsa051520.58569235
103Homologous recombination_Homo sapiens_hsa034400.57969496
104TGF-beta signaling pathway_Homo sapiens_hsa043500.57719069
105Long-term depression_Homo sapiens_hsa047300.56974681
106Renin-angiotensin system_Homo sapiens_hsa046140.56464785
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.55780701
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.55610739
109Insulin signaling pathway_Homo sapiens_hsa049100.55175511
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53732472
111Renin secretion_Homo sapiens_hsa049240.53470127
112Cholinergic synapse_Homo sapiens_hsa047250.52961723
113Glucagon signaling pathway_Homo sapiens_hsa049220.52818900
114HIF-1 signaling pathway_Homo sapiens_hsa040660.52597995
115Choline metabolism in cancer_Homo sapiens_hsa052310.52303767
116Melanoma_Homo sapiens_hsa052180.51522405
117Autoimmune thyroid disease_Homo sapiens_hsa053200.50952105
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50725599
119ABC transporters_Homo sapiens_hsa020100.50152460
120AMPK signaling pathway_Homo sapiens_hsa041520.49912005

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