ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	5.00554314
2	COPI coating of Golgi vesicle (GO:0048205)	4.63389106
3	Golgi transport vesicle coating (GO:0048200)	4.63389106
4	hemidesmosome assembly (GO:0031581)	4.46490188
5	nuclear pore organization (GO:0006999)	4.01324640
6	cell adhesion mediated by integrin (GO:0033627)	3.94931538
7	cell-substrate junction assembly (GO:0007044)	3.86535143
8	embryonic process involved in female pregnancy (GO:0060136)	3.68186674
9	hypotonic response (GO:0006971)	3.63737609
10	pore complex assembly (GO:0046931)	3.52598432
11	COPII vesicle coating (GO:0048208)	3.51130534
12	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	3.43961001
13	regulation of RNA export from nucleus (GO:0046831)	3.40438921
14	protein localization to endosome (GO:0036010)	3.38312714
15	skin morphogenesis (GO:0043589)	3.38257092
16	regulation of nucleobase-containing compound transport (GO:0032239)	3.32721180
17	vesicle coating (GO:0006901)	3.15785965
18	pinocytosis (GO:0006907)	3.14600017
19	cell-substrate adherens junction assembly (GO:0007045)	3.11747027
20	focal adhesion assembly (GO:0048041)	3.11747027
21	negative regulation of erythrocyte differentiation (GO:0045647)	3.09015507
22	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.98227377
23	endodermal cell differentiation (GO:0035987)	2.91083624
24	negative regulation of anoikis (GO:2000811)	2.90087633
25	negative regulation of fatty acid transport (GO:2000192)	2.89192504
26	adherens junction assembly (GO:0034333)	2.87867106
27	definitive hemopoiesis (GO:0060216)	2.86110097
28	response to laminar fluid shear stress (GO:0034616)	2.83740409
29	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.76942440
30	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.74436516
31	cortical actin cytoskeleton organization (GO:0030866)	2.72751027
32	protein retention in ER lumen (GO:0006621)	2.66780677
33	regulation of histone H3-K27 methylation (GO:0061085)	2.66159033
34	basement membrane organization (GO:0071711)	2.64259742
35	collagen fibril organization (GO:0030199)	2.59570025
36	dosage compensation (GO:0007549)	2.56051863
37	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	2.55570504
38	barbed-end actin filament capping (GO:0051016)	2.53945588
39	desmosome organization (GO:0002934)	2.53099306
40	membrane protein ectodomain proteolysis (GO:0006509)	2.52276288
41	regulation of glucose import in response to insulin stimulus (GO:2001273)	2.50264957
42	regulation of NFAT protein import into nucleus (GO:0051532)	2.49689969
43	negative regulation of protein localization to plasma membrane (GO:1903077)	2.48036250
44	histone H3-K9 demethylation (GO:0033169)	2.46000886
45	membrane raft organization (GO:0031579)	2.45820259
46	stress fiber assembly (GO:0043149)	2.45619661
47	regulation of anoikis (GO:2000209)	2.43579317
48	peptidyl-threonine modification (GO:0018210)	2.41044836
49	coronary vasculature morphogenesis (GO:0060977)	2.38483387
50	corticosteroid receptor signaling pathway (GO:0031958)	2.34078950
51	positive regulation of blood vessel endothelial cell migration (GO:0043536)	2.33674182
52	positive regulation of endothelial cell apoptotic process (GO:2000353)	2.33642421
53	negative regulation of fibrinolysis (GO:0051918)	2.33390512
54	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	2.29710237
55	protein hydroxylation (GO:0018126)	2.29305658
56	iron ion import (GO:0097286)	2.28900627
57	cellular hyperosmotic response (GO:0071474)	2.28624362
58	mesodermal cell differentiation (GO:0048333)	2.28153333
59	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.26319645
60	cortical cytoskeleton organization (GO:0030865)	2.25993375
61	urea cycle (GO:0000050)	2.25702945
62	actin filament-based movement (GO:0030048)	2.24447268
63	regulation of transforming growth factor beta2 production (GO:0032909)	2.24211214
64	cytoplasmic mRNA processing body assembly (GO:0033962)	2.24095931
65	histone H3-K36 demethylation (GO:0070544)	2.22385100
66	cellular response to osmotic stress (GO:0071470)	2.21819158
67	regulation of extracellular matrix disassembly (GO:0010715)	2.21804559
68	regulation of transforming growth factor beta1 production (GO:0032908)	2.21424280
69	urea metabolic process (GO:0019627)	2.20071121
70	epithelial cell-cell adhesion (GO:0090136)	2.17836902
71	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	2.17577231
72	activation of signaling protein activity involved in unfolded protein response (GO:0006987)	2.17327419
73	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	2.17230122
74	peptidyl-threonine phosphorylation (GO:0018107)	2.16989924
75	regulation of response to osmotic stress (GO:0047484)	2.16555296
76	peptidyl-proline hydroxylation (GO:0019511)	2.16428259
77	regulation of integrin activation (GO:0033623)	2.15789418
78	negative regulation of DNA repair (GO:0045738)	2.15362867
79	histone lysine demethylation (GO:0070076)	2.14321124
80	apoptotic cell clearance (GO:0043277)	2.14122872
81	regulation of necroptotic process (GO:0060544)	2.13404338
82	embryonic eye morphogenesis (GO:0048048)	2.13231970
83	endoplasmic reticulum unfolded protein response (GO:0030968)	2.11591674
84	embryonic camera-type eye morphogenesis (GO:0048596)	2.11492647
85	positive regulation of cellular response to insulin stimulus (GO:1900078)	2.11391305
86	peptidyl-lysine dimethylation (GO:0018027)	2.11332438
87	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	2.11225555
88	negative regulation of necroptotic process (GO:0060546)	2.10722503
89	positive regulation of receptor recycling (GO:0001921)	2.10023550
90	alpha-linolenic acid metabolic process (GO:0036109)	2.09634829
91	very-low-density lipoprotein particle assembly (GO:0034379)	2.09472807
92	ER-nucleus signaling pathway (GO:0006984)	2.09132965
93	positive regulation of nuclease activity (GO:0032075)	2.08897385
94	RNA stabilization (GO:0043489)	2.08332892
95	mRNA stabilization (GO:0048255)	2.08332892
96	negative regulation of potassium ion transmembrane transport (GO:1901380)	2.08106296
97	tricarboxylic acid metabolic process (GO:0072350)	2.08061166
98	response to epidermal growth factor (GO:0070849)	2.07877889
99	protein export from nucleus (GO:0006611)	2.07758659
100	collagen metabolic process (GO:0032963)	2.06980559

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	4.84865659
2	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	4.79201256
3	EGR1_19374776_ChIP-ChIP_THP-1_Human	3.91301928
4	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.79554718
5	CLOCK_20551151_ChIP-Seq_293T_Human	2.70244108
6	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.44427877
7	GATA1_22025678_ChIP-Seq_K562_Human	2.32009490
8	MYB_21317192_ChIP-Seq_ERMYB_Mouse	2.25384673
9	WT1_19549856_ChIP-ChIP_CCG9911_Human	2.11938008
10	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.00452015
11	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	2.00343683
12	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	2.00005351
13	E2F7_22180533_ChIP-Seq_HELA_Human	1.94667630
14	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.94484816
15	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.94175655
16	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.92947480
17	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.92947480
18	AR_21909140_ChIP-Seq_LNCAP_Human	1.89078326
19	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.87590654
20	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.85277353
21	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.85197593
22	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.82491954
23	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.78431164
24	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.76654080
25	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.75651296
26	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.75199915
27	TCF7_22412390_ChIP-Seq_EML_Mouse	1.70763167
28	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.66018938
29	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.65703362
30	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.65568670
31	ZNF263_19887448_ChIP-Seq_K562_Human	1.62127839
32	MYC_22102868_ChIP-Seq_BL_Human	1.61228472
33	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.59805199
34	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.58326189
35	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.57896250
36	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.57592060
37	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.56655334
38	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.55505218
39	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.55127623
40	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.53801239
41	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.53026020
42	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.50521566
43	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.50521566
44	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.50008873
45	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.49482046
46	* BRD4_25478319_ChIP-Seq_HGPS_Human	1.48240956
47	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.47296718
48	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.47014692
49	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.45644119
50	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.45019497
51	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.43760295
52	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.43482806
53	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.42274804
54	GATA1_19941826_ChIP-Seq_K562_Human	1.41748008
55	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.40160550
56	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.39764007
57	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.39587315
58	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.38888656
59	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.37090081
60	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.36252928
61	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.35521550
62	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.33571714
63	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.33022118
64	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.32045367
65	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.31765328
66	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.29624094
67	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.28144940
68	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.25470366
69	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.23071880
70	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.21564581
71	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.21540598
72	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.18959241
73	GATA2_19941826_ChIP-Seq_K562_Human	1.18203811
74	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.15993803
75	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	1.15458209
76	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.12715669
77	SPI1_23127762_ChIP-Seq_K562_Human	1.12181627
78	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.11859232
79	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.10794901
80	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.10302905
81	KDM2B_26808549_Chip-Seq_DND41_Human	1.10204631
82	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.10062735
83	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.09532343
84	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.08375600
85	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.07458585
86	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.06493596
87	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.04711066
88	PU_27001747_Chip-Seq_BMDM_Mouse	1.04596587
89	RUNX_20019798_ChIP-Seq_JUKART_Human	1.04441822
90	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.04436361
91	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.03944180
92	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.03563306
93	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.02639294
94	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.02274380
95	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.01864839
96	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.00823195
97	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.00363133
98	MAF_26560356_Chip-Seq_TH1_Human	1.00000149
99	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.99602605
100	GATA4_21415370_ChIP-Seq_HL-1_Mouse	0.98428357

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008438_abnormal_cutaneous_collagen	4.60319672
2	MP0003705_abnormal_hypodermis_morpholog	3.77666076
3	MP0003566_abnormal_cell_adhesion	2.95423044
4	MP0010352_gastrointestinal_tract_polyps	2.87264917
5	MP0002877_abnormal_melanocyte_morpholog	2.83871468
6	MP0005451_abnormal_body_composition	2.73298311
7	MP0004272_abnormal_basement_membrane	2.65062397
8	MP0003300_gastrointestinal_ulcer	2.60416620
9	MP0005275_abnormal_skin_tensile	2.53067561
10	MP0003091_abnormal_cell_migration	2.30475237
11	MP0002009_preneoplasia	2.16381942
12	MP0004084_abnormal_cardiac_muscle	1.98642176
13	MP0000751_myopathy	1.79871209
14	MP0001958_emphysema	1.77383147
15	MP0002166_altered_tumor_susceptibility	1.71742566
16	MP0002060_abnormal_skin_morphology	1.64441719
17	MP0004036_abnormal_muscle_relaxation	1.63158028
18	MP0005023_abnormal_wound_healing	1.62827713
19	MP0002396_abnormal_hematopoietic_system	1.62571852
20	MP0003656_abnormal_erythrocyte_physiolo	1.59132977
21	MP0004233_abnormal_muscle_weight	1.59102918
22	MP0003279_aneurysm	1.55380267
23	MP0003191_abnormal_cellular_cholesterol	1.55206088
24	MP0005076_abnormal_cell_differentiation	1.54585244
25	MP0003828_pulmonary_edema	1.54467593
26	MP0005623_abnormal_meninges_morphology	1.53547947
27	MP0001915_intracranial_hemorrhage	1.51400194
28	MP0000733_abnormal_muscle_development	1.45227838
29	MP0005409_darkened_coat_color	1.41356936
30	MP0010234_abnormal_vibrissa_follicle	1.40387317
31	MP0004087_abnormal_muscle_fiber	1.39752478
32	MP0003221_abnormal_cardiomyocyte_apopto	1.38334656
33	MP0010368_abnormal_lymphatic_system	1.38298160
34	MP0005257_abnormal_intraocular_pressure	1.37905290
35	MP0005503_abnormal_tendon_morphology	1.32133521
36	MP0004808_abnormal_hematopoietic_stem	1.30074598
37	MP0004185_abnormal_adipocyte_glucose	1.28941626
38	MP0000759_abnormal_skeletal_muscle	1.28714179
39	MP0003868_abnormal_feces_composition	1.27275629
40	MP0008057_abnormal_DNA_replication	1.26956035
41	MP0002269_muscular_atrophy	1.24980219
42	MP0000465_gastrointestinal_hemorrhage	1.22633641
43	MP0008260_abnormal_autophagy	1.20851893
44	MP0002896_abnormal_bone_mineralization	1.20138140
45	MP0000013_abnormal_adipose_tissue	1.18381686
46	MP0010630_abnormal_cardiac_muscle	1.17396697
47	MP0005058_abnormal_lysosome_morphology	1.14474724
48	MP0001849_ear_inflammation	1.13546880
49	MP0002006_tumorigenesis	1.13156888
50	MP0006138_congestive_heart_failure	1.12913864
51	MP0001661_extended_life_span	1.10664765
52	MP0000747_muscle_weakness	1.09839315
53	MP0006054_spinal_hemorrhage	1.09241032
54	MP0005666_abnormal_adipose_tissue	1.09083548
55	MP0005464_abnormal_platelet_physiology	1.07814980
56	MP0000767_abnormal_smooth_muscle	1.07634505
57	MP0005621_abnormal_cell_physiology	1.06488378
58	MP0003950_abnormal_plasma_membrane	1.06083370
59	MP0003045_fibrosis	1.05802100
60	MP0000003_abnormal_adipose_tissue	1.05727356
61	MP0003763_abnormal_thymus_physiology	1.04914828
62	MP0001851_eye_inflammation	1.02384216
63	MP0003453_abnormal_keratinocyte_physiol	1.01591789
64	MP0003329_amyloid_beta_deposits	0.99660706
65	MP0009697_abnormal_copulation	0.98928359
66	MP0003183_abnormal_peptide_metabolism	0.98310782
67	MP0004947_skin_inflammation	0.97502417
68	MP0005375_adipose_tissue_phenotype	0.96452379
69	MP0004264_abnormal_extraembryonic_tissu	0.96190874
70	MP0000858_altered_metastatic_potential	0.94952038
71	MP0000569_abnormal_digit_pigmentation	0.94324352
72	MP0000749_muscle_degeneration	0.92198852
73	MP0003941_abnormal_skin_development	0.91870911
74	MP0001243_abnormal_dermal_layer	0.91637684
75	MP0002086_abnormal_extraembryonic_tissu	0.90527724
76	MP0005330_cardiomyopathy	0.89287010
77	MP0003385_abnormal_body_wall	0.88173945
78	MP0002998_abnormal_bone_remodeling	0.84649738
79	MP0003984_embryonic_growth_retardation	0.83013196
80	MP0001348_abnormal_lacrimal_gland	0.82133929
81	MP0002128_abnormal_blood_circulation	0.81599395
82	MP0010307_abnormal_tumor_latency	0.81493331
83	MP0005164_abnormal_response_to	0.80598085
84	MP0000428_abnormal_craniofacial_morphol	0.79384240
85	MP0009384_cardiac_valve_regurgitation	0.79160353
86	MP0002088_abnormal_embryonic_growth/wei	0.77035572
87	MP0002971_abnormal_brown_adipose	0.76599580
88	MP0003448_altered_tumor_morphology	0.74724826
89	MP0001730_embryonic_growth_arrest	0.74632405
90	MP0009840_abnormal_foam_cell	0.74596994
91	MP0004858_abnormal_nervous_system	0.74353603
92	MP0002925_abnormal_cardiovascular_devel	0.73615073
93	MP0001614_abnormal_blood_vessel	0.73346888
94	MP0005408_hypopigmentation	0.71610897
95	MP0004130_abnormal_muscle_cell	0.71515188
96	MP0009780_abnormal_chondrocyte_physiolo	0.70805248
97	MP0004134_abnormal_chest_morphology	0.70706587
98	MP0001545_abnormal_hematopoietic_system	0.70332814
99	MP0005397_hematopoietic_system_phenotyp	0.70332814
100	MP0003115_abnormal_respiratory_system	0.69648509

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Protrusio acetabuli (HP:0003179)	4.37029536
2	Premature rupture of membranes (HP:0001788)	3.85715265
3	Arterial tortuosity (HP:0005116)	3.41963201
4	Atrophic scars (HP:0001075)	3.33597757
5	Vascular tortuosity (HP:0004948)	3.32842906
6	Aortic dissection (HP:0002647)	3.16991453
7	Aortic aneurysm (HP:0004942)	3.01353980
8	Increased connective tissue (HP:0009025)	2.94290455
9	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.79424702
10	Osteolytic defects of the hand bones (HP:0009699)	2.79424702
11	Wormian bones (HP:0002645)	2.66088122
12	Fragile skin (HP:0001030)	2.64484064
13	Increased variability in muscle fiber diameter (HP:0003557)	2.59320865
14	Exercise-induced myalgia (HP:0003738)	2.52661602
15	Dilatation of the ascending aorta (HP:0005111)	2.51708530
16	Abnormality of skeletal muscle fiber size (HP:0012084)	2.49671890
17	Type 1 muscle fiber predominance (HP:0003803)	2.49545894
18	Distal lower limb amyotrophy (HP:0008944)	2.45149326
19	Insidious onset (HP:0003587)	2.41610561
20	Termporal pattern (HP:0011008)	2.41610561
21	Aneurysm (HP:0002617)	2.38486030
22	Peritonitis (HP:0002586)	2.38199963
23	Ankyloglossia (HP:0010296)	2.38040474
24	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.36777498
25	Flat acetabular roof (HP:0003180)	2.36050675
26	Vertebral compression fractures (HP:0002953)	2.33019866
27	Cerebral aneurysm (HP:0004944)	2.31161076
28	Subacute progressive viral hepatitis (HP:0006572)	2.27987879
29	Right ventricular cardiomyopathy (HP:0011663)	2.27429532
30	Back pain (HP:0003418)	2.27355083
31	Mitral valve prolapse (HP:0001634)	2.23105746
32	Vertebral arch anomaly (HP:0008438)	2.19407178
33	Ankle contracture (HP:0006466)	2.16494056
34	Spinal rigidity (HP:0003306)	2.16380619
35	Spondylolisthesis (HP:0003302)	2.12853599
36	Abnormality of oral frenula (HP:0000190)	2.12546058
37	Bladder diverticulum (HP:0000015)	2.10796167
38	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	2.08921205
39	Increased mean platelet volume (HP:0011877)	2.07279207
40	Mildly elevated creatine phosphokinase (HP:0008180)	2.05183993
41	Hyperacusis (HP:0010780)	2.03877499
42	Soft skin (HP:0000977)	2.00829310
43	Overgrowth (HP:0001548)	2.00072478
44	Abnormality of the acetabulum (HP:0003170)	2.00070682
45	Cervical subluxation (HP:0003308)	1.99381139
46	Short nail (HP:0001799)	1.99373039
47	Syringomyelia (HP:0003396)	1.98605154
48	Spinal cord lesions (HP:0100561)	1.98605154
49	Papillary thyroid carcinoma (HP:0002895)	1.97021813
50	Neonatal short-limb short stature (HP:0008921)	1.96298839
51	Asymmetry of the thorax (HP:0001555)	1.91523634
52	Abnormal platelet volume (HP:0011876)	1.91262499
53	Joint laxity (HP:0001388)	1.89818495
54	Abnormality of the left ventricular outflow tract (HP:0011103)	1.89090987
55	Subaortic stenosis (HP:0001682)	1.89090987
56	Abnormality of the common coagulation pathway (HP:0010990)	1.89056882
57	Broad face (HP:0000283)	1.86102375
58	Periodontitis (HP:0000704)	1.83418748
59	Abnormality of dentin (HP:0010299)	1.83298455
60	Thin bony cortex (HP:0002753)	1.82530920
61	Advanced eruption of teeth (HP:0006288)	1.82163070
62	Fatigue (HP:0012378)	1.81925383
63	Deep venous thrombosis (HP:0002625)	1.78793928
64	Milia (HP:0001056)	1.77733667
65	Achilles tendon contracture (HP:0001771)	1.76371041
66	Breech presentation (HP:0001623)	1.76049520
67	Mitral stenosis (HP:0001718)	1.76000325
68	Cupped ribs (HP:0000887)	1.75974845
69	Ventricular tachycardia (HP:0004756)	1.75529463
70	Blue sclerae (HP:0000592)	1.75068672
71	Natal tooth (HP:0000695)	1.73969186
72	Polycythemia (HP:0001901)	1.73919277
73	Upper limb amyotrophy (HP:0009129)	1.73000357
74	Distal upper limb amyotrophy (HP:0007149)	1.73000357
75	Gingival bleeding (HP:0000225)	1.71893609
76	Delayed closure of the anterior fontanelle (HP:0001476)	1.71520536
77	Lower limb amyotrophy (HP:0007210)	1.71208512
78	Abnormal delivery (HP:0001787)	1.71002744
79	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	1.70673149
80	Nemaline bodies (HP:0003798)	1.70055947
81	Mitral regurgitation (HP:0001653)	1.69489802
82	Relative macrocephaly (HP:0004482)	1.69433197
83	Disproportionate tall stature (HP:0001519)	1.69014057
84	Coarse hair (HP:0002208)	1.67573488
85	Ulnar bowing (HP:0003031)	1.67271286
86	Dysmetric saccades (HP:0000641)	1.66717943
87	Abnormality of the Achilles tendon (HP:0005109)	1.66120418
88	Absent frontal sinuses (HP:0002688)	1.64729700
89	Dislocated radial head (HP:0003083)	1.63870620
90	Hammertoe (HP:0001765)	1.63660774
91	Muscle fiber inclusion bodies (HP:0100299)	1.62908430
92	Heterotopia (HP:0002282)	1.62402023
93	Menorrhagia (HP:0000132)	1.61989229
94	Abnormality of the fingertips (HP:0001211)	1.61722233
95	Abnormal ossification of hand bones (HP:0005921)	1.61408404
96	Elbow flexion contracture (HP:0002987)	1.61272687
97	Abnormality of carpal bone ossification (HP:0006257)	1.61231215
98	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.60266868
99	Asymmetric septal hypertrophy (HP:0001670)	1.59416696
100	Myocardial infarction (HP:0001658)	1.58336821

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK12	3.46907740
2	PDGFRA	3.28427110
3	EEF2K	2.78647869
4	TTN	2.73716830
5	PRPF4B	2.64139600
6	NEK9	2.63014460
7	TRIB3	2.61091261
8	SCYL2	2.58868185
9	MST1R	2.42000231
10	RIPK1	2.31610817
11	FGFR4	2.13011716
12	ICK	1.96492386
13	LATS1	1.83360692
14	BRD4	1.76251264
15	TRPM7	1.76112109
16	FGFR3	1.65674429
17	MET	1.64446555
18	KSR2	1.58902296
19	JAK1	1.50056269
20	PKN2	1.47030498
21	CAMK1G	1.42974380
22	CDK6	1.42935262
23	PIK3CG	1.40532813
24	PDGFRB	1.39111697
25	TGFBR2	1.38933325
26	CAMK1D	1.36094978
27	ERN1	1.34876844
28	MAP3K14	1.33534646
29	MAP3K6	1.30460039
30	RET	1.29873583
31	NTRK1	1.29553374
32	LATS2	1.25372704
33	DDR2	1.24062031
34	PAK2	1.23231796
35	SMG1	1.22086331
36	MAP3K10	1.21461252
37	MTOR	1.20936966
38	MAP2K3	1.16123608
39	SIK1	1.15501153
40	WNK1	1.13361386
41	CDC42BPA	1.11547767
42	MAP3K2	1.11515544
43	AKT3	1.00384579
44	PTK2	0.91976442
45	BMPR2	0.91546299
46	JAK3	0.89700081
47	OBSCN	0.88768418
48	MOS	0.86724118
49	STK38	0.84132957
50	KSR1	0.83638275
51	ZAP70	0.82605775
52	MAPK11	0.81908476
53	EPHB1	0.81293178
54	RAF1	0.78548084
55	TYK2	0.76651605
56	JAK2	0.76334533
57	MAP3K13	0.75399231
58	SGK3	0.72970923
59	PAK4	0.71927085
60	EPHA3	0.71736498
61	CLK1	0.69723450
62	EIF2AK1	0.64391607
63	FLT3	0.62258864
64	MARK2	0.60401891
65	ERBB3	0.59931809
66	MAP3K7	0.59905767
67	PRKAA2	0.59744079
68	RIPK4	0.58474050
69	IRAK3	0.57672546
70	CDK4	0.57662999
71	YES1	0.56196749
72	MAP3K1	0.52595926
73	RPS6KA2	0.51336997
74	BTK	0.47638659
75	MAP3K5	0.47231713
76	MYLK	0.46883248
77	PDPK1	0.46623849
78	PTK6	0.46596578
79	BMX	0.44083949
80	MAP3K8	0.43835231
81	CSF1R	0.43598973
82	HCK	0.43355975
83	MAPK7	0.42700403
84	DMPK	0.42297648
85	RPS6KB2	0.42281630
86	MELK	0.42189714
87	MAPK10	0.42037477
88	STK10	0.41749817
89	MAP3K3	0.39992562
90	ROCK2	0.37704371
91	DYRK1B	0.36956680
92	LMTK2	0.35583277
93	CDK9	0.35465961
94	PDK1	0.34309907
95	CAMKK2	0.30615239
96	ERBB4	0.30526034
97	MAPK12	0.30148273
98	CHEK1	0.29542335
99	TEC	0.29530411
100	RPS6KB1	0.29422493

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.37186891
2	Chronic myeloid leukemia_Homo sapiens_hsa05220	2.04308808
3	ECM-receptor interaction_Homo sapiens_hsa04512	1.99457456
4	Focal adhesion_Homo sapiens_hsa04510	1.98804791
5	Non-small cell lung cancer_Homo sapiens_hsa05223	1.88346159
6	Pancreatic cancer_Homo sapiens_hsa05212	1.83868865
7	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.73828855
8	Small cell lung cancer_Homo sapiens_hsa05222	1.72255120
9	Adherens junction_Homo sapiens_hsa04520	1.63378057
10	Thyroid cancer_Homo sapiens_hsa05216	1.61280272
11	Endometrial cancer_Homo sapiens_hsa05213	1.61122894
12	Renal cell carcinoma_Homo sapiens_hsa05211	1.56121035
13	Acute myeloid leukemia_Homo sapiens_hsa05221	1.55848186
14	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.51976830
15	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.48240760
16	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.41175531
17	Proteoglycans in cancer_Homo sapiens_hsa05205	1.39955177
18	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.39950513
19	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.37027543
20	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.34128456
21	Amoebiasis_Homo sapiens_hsa05146	1.33582278
22	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.33023647
23	Glioma_Homo sapiens_hsa05214	1.27942840
24	Other glycan degradation_Homo sapiens_hsa00511	1.24878333
25	MicroRNAs in cancer_Homo sapiens_hsa05206	1.22264065
26	Platelet activation_Homo sapiens_hsa04611	1.22209728
27	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.22047787
28	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.21349975
29	ErbB signaling pathway_Homo sapiens_hsa04012	1.20566308
30	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.20240259
31	Prolactin signaling pathway_Homo sapiens_hsa04917	1.20035158
32	mTOR signaling pathway_Homo sapiens_hsa04150	1.20014421
33	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.18965519
34	Bladder cancer_Homo sapiens_hsa05219	1.18713978
35	Colorectal cancer_Homo sapiens_hsa05210	1.15121637
36	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.14300726
37	Prostate cancer_Homo sapiens_hsa05215	1.14186739
38	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	1.12840152
39	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.11251266
40	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.11134276
41	VEGF signaling pathway_Homo sapiens_hsa04370	1.07113850
42	Insulin signaling pathway_Homo sapiens_hsa04910	1.05852108
43	Hepatitis B_Homo sapiens_hsa05161	1.04520751
44	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.97293169
45	Insulin resistance_Homo sapiens_hsa04931	0.96293449
46	Choline metabolism in cancer_Homo sapiens_hsa05231	0.96061106
47	Toxoplasmosis_Homo sapiens_hsa05145	0.95991024
48	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.95170295
49	Viral carcinogenesis_Homo sapiens_hsa05203	0.91242628
50	Lysine degradation_Homo sapiens_hsa00310	0.87737714
51	Complement and coagulation cascades_Homo sapiens_hsa04610	0.87225281
52	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.86730015
53	AMPK signaling pathway_Homo sapiens_hsa04152	0.85980006
54	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.84827980
55	Renin-angiotensin system_Homo sapiens_hsa04614	0.84002057
56	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.83249036
57	GnRH signaling pathway_Homo sapiens_hsa04912	0.82667582
58	FoxO signaling pathway_Homo sapiens_hsa04068	0.79969165
59	Pentose phosphate pathway_Homo sapiens_hsa00030	0.79458528
60	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.78109062
61	Shigellosis_Homo sapiens_hsa05131	0.77205167
62	Apoptosis_Homo sapiens_hsa04210	0.75599116
63	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.74364140
64	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.73650423
65	Prion diseases_Homo sapiens_hsa05020	0.72910871
66	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.72101220
67	Protein digestion and absorption_Homo sapiens_hsa04974	0.71402544
68	Pathways in cancer_Homo sapiens_hsa05200	0.71297578
69	Measles_Homo sapiens_hsa05162	0.70583618
70	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.69786514
71	Hepatitis C_Homo sapiens_hsa05160	0.69505331
72	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.68939798
73	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.68876625
74	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.68340134
75	Estrogen signaling pathway_Homo sapiens_hsa04915	0.67952787
76	Osteoclast differentiation_Homo sapiens_hsa04380	0.66981053
77	TNF signaling pathway_Homo sapiens_hsa04668	0.66119069
78	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.65977816
79	Influenza A_Homo sapiens_hsa05164	0.65846887
80	Viral myocarditis_Homo sapiens_hsa05416	0.65603098
81	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.63015723
82	Long-term potentiation_Homo sapiens_hsa04720	0.61940921
83	Endocytosis_Homo sapiens_hsa04144	0.58262208
84	Galactose metabolism_Homo sapiens_hsa00052	0.57327812
85	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.55492793
86	Notch signaling pathway_Homo sapiens_hsa04330	0.55334902
87	Arginine biosynthesis_Homo sapiens_hsa00220	0.55170708
88	Leishmaniasis_Homo sapiens_hsa05140	0.55158287
89	Carbon metabolism_Homo sapiens_hsa01200	0.54493128
90	Gap junction_Homo sapiens_hsa04540	0.53497318
91	Glucagon signaling pathway_Homo sapiens_hsa04922	0.52144216
92	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.51745847
93	Melanoma_Homo sapiens_hsa05218	0.51378793
94	HTLV-I infection_Homo sapiens_hsa05166	0.51234853
95	Malaria_Homo sapiens_hsa05144	0.50728433
96	Type II diabetes mellitus_Homo sapiens_hsa04930	0.50555435
97	PPAR signaling pathway_Homo sapiens_hsa03320	0.49759748
98	Salmonella infection_Homo sapiens_hsa05132	0.46504901
99	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.46383080
100	Rap1 signaling pathway_Homo sapiens_hsa04015	0.44464573

BIVM-ERCC5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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