BLACE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to exogenous dsRNA (GO:0071360)4.45262662
2DNA deamination (GO:0045006)4.35995088
3regulation of sarcomere organization (GO:0060297)4.11709908
4regulation of germinal center formation (GO:0002634)3.98906351
5response to pheromone (GO:0019236)3.85746341
6negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.77437229
7negative regulation of T-helper cell differentiation (GO:0045623)3.77437229
8regulation of vitamin D biosynthetic process (GO:0060556)3.75819498
9cellular response to ATP (GO:0071318)3.73407828
10regulation of penile erection (GO:0060405)3.58453240
11regulation of heat generation (GO:0031650)3.54426722
12negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.50651107
13regulation of interferon-alpha production (GO:0032647)3.34626506
14positive regulation of defense response to virus by host (GO:0002230)3.30750881
15positive regulation of prostaglandin secretion (GO:0032308)3.30423274
16neural tube formation (GO:0001841)3.25258579
17glial cell proliferation (GO:0014009)3.22337946
18behavioral response to nicotine (GO:0035095)3.14860909
19regulation of T cell cytokine production (GO:0002724)3.13030048
20positive regulation of heat generation (GO:0031652)3.10097094
21regulation of B cell apoptotic process (GO:0002902)3.09705594
22indolalkylamine metabolic process (GO:0006586)3.09125044
23tryptophan metabolic process (GO:0006568)3.08467651
24regulation of chronic inflammatory response (GO:0002676)3.07714771
25response to ATP (GO:0033198)3.07713169
26piRNA metabolic process (GO:0034587)3.02210384
27positive regulation of interferon-beta production (GO:0032728)3.01841383
28purinergic nucleotide receptor signaling pathway (GO:0035590)3.00135064
29positive regulation of interferon-alpha production (GO:0032727)2.98934024
30negative regulation of mast cell activation (GO:0033004)2.98169836
31regulation of T-helper 1 cell differentiation (GO:0045625)2.97484765
32regulation of vitamin metabolic process (GO:0030656)2.97372584
33replication fork processing (GO:0031297)2.93376652
34regulation of T cell tolerance induction (GO:0002664)2.92604331
35regulation of T-helper cell differentiation (GO:0045622)2.89541434
36positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.88578458
37positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.88508758
38regulation of prostaglandin secretion (GO:0032306)2.87031103
39indole-containing compound catabolic process (GO:0042436)2.84560826
40indolalkylamine catabolic process (GO:0046218)2.84560826
41tryptophan catabolic process (GO:0006569)2.84560826
42regulation of meiosis I (GO:0060631)2.84042851
43protein K11-linked deubiquitination (GO:0035871)2.81500361
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.80811115
45L-fucose catabolic process (GO:0042355)2.79450271
46fucose catabolic process (GO:0019317)2.79450271
47L-fucose metabolic process (GO:0042354)2.79450271
48negative regulation of telomere maintenance (GO:0032205)2.79043109
49ubiquinone biosynthetic process (GO:0006744)2.78451622
50adenosine metabolic process (GO:0046085)2.78348012
51positive regulation of cAMP-mediated signaling (GO:0043950)2.74126497
52positive regulation of interleukin-1 beta secretion (GO:0050718)2.73266107
53negative regulation of alpha-beta T cell differentiation (GO:0046639)2.70959269
54regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.70833973
55ubiquinone metabolic process (GO:0006743)2.70704461
56cellular response to dsRNA (GO:0071359)2.70259959
57regulation of interferon-beta production (GO:0032648)2.69157533
58positive regulation of chemokine biosynthetic process (GO:0045080)2.66448567
59positive regulation of natural killer cell differentiation (GO:0032825)2.66243521
60regulation of memory T cell differentiation (GO:0043380)2.65418618
61regulation of defense response to virus by host (GO:0050691)2.64901596
62germinal center formation (GO:0002467)2.64883451
63platelet dense granule organization (GO:0060155)2.61662864
64epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.59705988
65positive regulation of mast cell activation involved in immune response (GO:0033008)2.59527727
66positive regulation of mast cell degranulation (GO:0043306)2.59527727
67DNA methylation involved in gamete generation (GO:0043046)2.57967700
68negative regulation of monooxygenase activity (GO:0032769)2.57385129
69positive regulation of interleukin-1 secretion (GO:0050716)2.56976394
70regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.55018533
71cytokine biosynthetic process (GO:0042089)2.54510312
72imidazole-containing compound metabolic process (GO:0052803)2.54279646
73kynurenine metabolic process (GO:0070189)2.52829975
74regulation of interleukin-1 beta secretion (GO:0050706)2.49248705
75defense response to protozoan (GO:0042832)2.48427069
76mannosylation (GO:0097502)2.47963201
77positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.47898318
78DNA double-strand break processing (GO:0000729)2.47853727
79cellular biogenic amine biosynthetic process (GO:0042401)2.45967946
80positive regulation of fatty acid transport (GO:2000193)2.45620539
81adaptation of signaling pathway (GO:0023058)2.45543906
82regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.45155798
83positive regulation of DNA recombination (GO:0045911)2.43468418
84positive regulation of phosphatase activity (GO:0010922)2.41103232
85positive regulation of granulocyte differentiation (GO:0030854)2.40156190
86response to protozoan (GO:0001562)2.39581687
87positive regulation of T-helper 1 type immune response (GO:0002827)2.39466258
88regulation of T-helper 1 type immune response (GO:0002825)2.38668981
89regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.36835733
90negative regulation of thymocyte apoptotic process (GO:0070244)2.36573557
91DNA integration (GO:0015074)2.36329003
92amine biosynthetic process (GO:0009309)2.36052116
93histamine secretion (GO:0001821)2.35567915
94regulation of tolerance induction (GO:0002643)2.35348687
95regulation of MHC class I biosynthetic process (GO:0045343)2.34438988
96regulation of MHC class II biosynthetic process (GO:0045346)2.32939324
97negative regulation of interleukin-1 beta production (GO:0032691)2.32872761
98positive regulation of interleukin-1 beta production (GO:0032731)2.32284334
99positive regulation of calcium-mediated signaling (GO:0050850)2.31965026
100protein localization to cilium (GO:0061512)2.29374357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.60343097
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.07143823
3ZNF274_21170338_ChIP-Seq_K562_Hela3.96718420
4VDR_22108803_ChIP-Seq_LS180_Human3.67020426
5IGF1R_20145208_ChIP-Seq_DFB_Human2.96349728
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.66037301
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46886258
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36589799
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32986975
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24887892
11GBX2_23144817_ChIP-Seq_PC3_Human2.19242239
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.17276175
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04767622
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92879732
15ER_23166858_ChIP-Seq_MCF-7_Human1.90411776
16IRF8_21731497_ChIP-ChIP_J774_Mouse1.89348198
17EWS_26573619_Chip-Seq_HEK293_Human1.85675157
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.80456856
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72365966
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.71973211
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64453990
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63088833
23P300_19829295_ChIP-Seq_ESCs_Human1.60672417
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.60020471
25FUS_26573619_Chip-Seq_HEK293_Human1.57279522
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55444102
27NR3C1_21868756_ChIP-Seq_MCF10A_Human1.54720701
28VDR_24787735_ChIP-Seq_THP-1_Human1.53813130
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.52966570
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51717712
31CBP_20019798_ChIP-Seq_JUKART_Human1.51717712
32BCAT_22108803_ChIP-Seq_LS180_Human1.48711566
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48412649
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45356296
35GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41815590
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40475034
37TP53_22573176_ChIP-Seq_HFKS_Human1.38478588
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38199251
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.37176604
40SOX2_19829295_ChIP-Seq_ESCs_Human1.36506543
41NANOG_19829295_ChIP-Seq_ESCs_Human1.36506543
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35895920
43SCL_19346495_ChIP-Seq_HPC-7_Human1.35051990
44GATA3_26560356_Chip-Seq_TH2_Human1.34846152
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34261720
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.33538853
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32756192
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31649564
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29869365
50STAT3_23295773_ChIP-Seq_U87_Human1.26901627
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.26249028
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.26230717
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24969113
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24969113
55AR_25329375_ChIP-Seq_VCAP_Human1.23951443
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.22427041
57ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22000139
58TCF4_22108803_ChIP-Seq_LS180_Human1.20434218
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19672027
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19241546
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18325666
62TCF4_23295773_ChIP-Seq_U87_Human1.17038473
63MYC_18940864_ChIP-ChIP_HL60_Human1.13795571
64SMAD4_21799915_ChIP-Seq_A2780_Human1.13211148
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13153442
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12271535
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10346591
68RUNX2_22187159_ChIP-Seq_PCA_Human1.07534382
69IRF1_19129219_ChIP-ChIP_H3396_Human1.07529253
70NCOR_22424771_ChIP-Seq_293T_Human1.07506770
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06474081
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.06474081
73SMRT_27268052_Chip-Seq_Bcells_Human1.05554585
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05111513
75AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05019542
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04162861
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.03943139
78IRF8_27001747_Chip-Seq_BMDM_Mouse1.03888048
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.02854977
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00631514
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00508382
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.00408475
83ELK1_19687146_ChIP-ChIP_HELA_Human0.99943179
84TAF15_26573619_Chip-Seq_HEK293_Human0.99402568
85KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98066587
86GABP_17652178_ChIP-ChIP_JURKAT_Human0.97846615
87NANOG_18555785_Chip-Seq_ESCs_Mouse0.97152034
88TAF2_19829295_ChIP-Seq_ESCs_Human0.96856559
89TP53_16413492_ChIP-PET_HCT116_Human0.96591966
90CDX2_22108803_ChIP-Seq_LS180_Human0.96372668
91TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95816098
92SMAD4_21741376_ChIP-Seq_EPCs_Human0.95303315
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.95282940
94GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95275032
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95134152
96AR_20517297_ChIP-Seq_VCAP_Human0.95120747
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94967826
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.93967756
99MYB_26560356_Chip-Seq_TH2_Human0.93332549
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.92791201

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.49689533
2MP0008877_abnormal_DNA_methylation3.16769799
3MP0003195_calcinosis3.00523661
4MP0001835_abnormal_antigen_presentation2.86533085
5MP0002148_abnormal_hypersensitivity_rea2.64417490
6MP0003950_abnormal_plasma_membrane2.62995343
7MP0006082_CNS_inflammation2.44122345
8MP0003303_peritoneal_inflammation2.31480402
9MP0003646_muscle_fatigue2.24877996
10MP0002735_abnormal_chemical_nociception2.20453019
11MP0002254_reproductive_system_inflammat2.17207469
12MP0000372_irregular_coat_pigmentation2.16848356
13MP0005174_abnormal_tail_pigmentation2.11303539
14MP0003724_increased_susceptibility_to2.06523965
15MP0001501_abnormal_sleep_pattern2.05046054
16MP0009785_altered_susceptibility_to2.04845381
17MP0000015_abnormal_ear_pigmentation2.04721472
18MP0005084_abnormal_gallbladder_morpholo1.99010859
19MP0002138_abnormal_hepatobiliary_system1.93240225
20MP0003787_abnormal_imprinting1.90907103
21MP0009764_decreased_sensitivity_to1.85081169
22MP0006054_spinal_hemorrhage1.81726805
23MP0002876_abnormal_thyroid_physiology1.71603052
24MP0001968_abnormal_touch/_nociception1.70302812
25MP0001790_abnormal_immune_system1.65923251
26MP0005387_immune_system_phenotype1.65923251
27MP0005000_abnormal_immune_tolerance1.60912150
28MP0005167_abnormal_blood-brain_barrier1.58590061
29MP0005171_absent_coat_pigmentation1.58328913
30MP0008872_abnormal_physiological_respon1.57507051
31MP0002102_abnormal_ear_morphology1.56633910
32MP0005410_abnormal_fertilization1.50056315
33MP0001800_abnormal_humoral_immune1.49202420
34MP0002837_dystrophic_cardiac_calcinosis1.46878662
35MP0003718_maternal_effect1.43050204
36MP0005551_abnormal_eye_electrophysiolog1.41574263
37MP0002723_abnormal_immune_serum1.39805664
38MP0004043_abnormal_pH_regulation1.39725256
39MP0008057_abnormal_DNA_replication1.38784760
40MP0005671_abnormal_response_to1.36939275
41MP0002452_abnormal_antigen_presenting1.36248193
42MP0008058_abnormal_DNA_repair1.34729716
43MP0001545_abnormal_hematopoietic_system1.34398937
44MP0005397_hematopoietic_system_phenotyp1.34398937
45MP0001986_abnormal_taste_sensitivity1.29596254
46MP0005025_abnormal_response_to1.26133283
47MP0005075_abnormal_melanosome_morpholog1.25851373
48MP0002419_abnormal_innate_immunity1.25566672
49MP0005389_reproductive_system_phenotype1.25487996
50MP0004742_abnormal_vestibular_system1.24610661
51MP0008875_abnormal_xenobiotic_pharmacok1.20822898
52MP0005645_abnormal_hypothalamus_physiol1.20524280
53MP0005310_abnormal_salivary_gland1.18289632
54MP0000685_abnormal_immune_system1.14648548
55MP0002006_tumorigenesis1.14290862
56MP0002733_abnormal_thermal_nociception1.11807514
57MP0002736_abnormal_nociception_after1.10222243
58MP0003011_delayed_dark_adaptation1.09076580
59MP0005647_abnormal_sex_gland1.07307212
60MP0000427_abnormal_hair_cycle1.06450083
61MP0002139_abnormal_hepatobiliary_system1.06200839
62MP0001819_abnormal_immune_cell1.05783194
63MP0002420_abnormal_adaptive_immunity1.05269503
64MP0005646_abnormal_pituitary_gland1.03594818
65MP0001919_abnormal_reproductive_system1.03277022
66MP0003436_decreased_susceptibility_to1.01818857
67MP0002095_abnormal_skin_pigmentation1.01249582
68MP0009046_muscle_twitch1.00086546
69MP0009745_abnormal_behavioral_response0.98522706
70MP0008469_abnormal_protein_level0.97420419
71MP0005365_abnormal_bile_salt0.97332515
72MP0009697_abnormal_copulation0.96678818
73MP0001485_abnormal_pinna_reflex0.94821585
74MP0008995_early_reproductive_senescence0.94644505
75MP0005253_abnormal_eye_physiology0.94629181
76MP0009278_abnormal_bone_marrow0.94277835
77MP0002332_abnormal_exercise_endurance0.93170680
78MP0002160_abnormal_reproductive_system0.91645643
79MP0005386_behavior/neurological_phenoty0.89278894
80MP0004924_abnormal_behavior0.89278894
81MP0002405_respiratory_system_inflammati0.88535173
82MP0001845_abnormal_inflammatory_respons0.88438837
83MP0009765_abnormal_xenobiotic_induced0.87016867
84MP0001970_abnormal_pain_threshold0.86509088
85MP0005266_abnormal_metabolism0.85727244
86MP0004484_altered_response_of0.84283871
87MP0000716_abnormal_immune_system0.83616368
88MP0001873_stomach_inflammation0.80976636
89MP0003880_abnormal_central_pattern0.80191208
90MP0004147_increased_porphyrin_level0.79173839
91MP0004883_abnormal_blood_vessel0.77425379
92MP0001348_abnormal_lacrimal_gland0.74962345
93MP0001764_abnormal_homeostasis0.73851647
94MP0000230_abnormal_systemic_arterial0.73543901
95MP0009333_abnormal_splenocyte_physiolog0.73115305
96MP0000371_diluted_coat_color0.72115535
97MP0000383_abnormal_hair_follicle0.71817266
98MP0004381_abnormal_hair_follicle0.70891322
99MP0005448_abnormal_energy_balance0.70307910
100MP0000516_abnormal_urinary_system0.70281468

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of B cell number (HP:0010975)4.46805240
2B lymphocytopenia (HP:0010976)4.27973502
3Absent rod-and cone-mediated responses on ERG (HP:0007688)3.70379756
4Attenuation of retinal blood vessels (HP:0007843)3.69390983
5Hyperventilation (HP:0002883)3.58508964
6Panhypogammaglobulinemia (HP:0003139)3.48425375
7Hypoproteinemia (HP:0003075)3.42618655
8Autoimmune thrombocytopenia (HP:0001973)3.12532027
9Pancreatic cysts (HP:0001737)3.10244535
10Abolished electroretinogram (ERG) (HP:0000550)3.03713337
11Thyroiditis (HP:0100646)3.01377845
12Abnormal delayed hypersensitivity skin test (HP:0002963)2.94314383
13Abnormal rod and cone electroretinograms (HP:0008323)2.91559805
14Stomatitis (HP:0010280)2.89115930
15Pendular nystagmus (HP:0012043)2.86528250
16Congenital stationary night blindness (HP:0007642)2.86204899
17Absent speech (HP:0001344)2.85746496
18Type II lissencephaly (HP:0007260)2.81209215
19Retrobulbar optic neuritis (HP:0100654)2.73645735
20Optic neuritis (HP:0100653)2.73645735
21Pancreatic fibrosis (HP:0100732)2.67286768
22Molar tooth sign on MRI (HP:0002419)2.62990079
23Abnormality of midbrain morphology (HP:0002418)2.62990079
24Decreased central vision (HP:0007663)2.62027918
25Elevated erythrocyte sedimentation rate (HP:0003565)2.58102404
26Mesangial abnormality (HP:0001966)2.54923223
27Congenital sensorineural hearing impairment (HP:0008527)2.54564481
28Increased corneal curvature (HP:0100692)2.49067168
29Keratoconus (HP:0000563)2.49067168
30Severe combined immunodeficiency (HP:0004430)2.43295965
31Bony spicule pigmentary retinopathy (HP:0007737)2.40348039
32Type I transferrin isoform profile (HP:0003642)2.36553451
33True hermaphroditism (HP:0010459)2.28973327
34Recurrent cutaneous fungal infections (HP:0011370)2.28630227
35Chronic mucocutaneous candidiasis (HP:0002728)2.28630227
36Ketoacidosis (HP:0001993)2.27821960
37Abnormal albumin level (HP:0012116)2.26822141
38Hypoalbuminemia (HP:0003073)2.26822141
39Abnormality of the renal cortex (HP:0011035)2.26339633
40Abnormality of the pons (HP:0007361)2.25660918
41Orchitis (HP:0100796)2.23853500
42Small hand (HP:0200055)2.23841264
43Tubular atrophy (HP:0000092)2.23210550
44Abnormal drinking behavior (HP:0030082)2.22320078
45Polydipsia (HP:0001959)2.22320078
46Widely spaced teeth (HP:0000687)2.20780890
47Inability to walk (HP:0002540)2.15158094
48Reduced antithrombin III activity (HP:0001976)2.12522223
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12127350
50Keratoconjunctivitis (HP:0001096)2.11575321
51Hypoplasia of the pons (HP:0012110)2.09843017
52Progressive inability to walk (HP:0002505)2.09424972
53Renal cortical cysts (HP:0000803)2.03167127
54Myositis (HP:0100614)2.02463964
55Gaze-evoked nystagmus (HP:0000640)2.02462227
56IgG deficiency (HP:0004315)1.98922683
57Abnormal protein glycosylation (HP:0012346)1.98328586
58Abnormal glycosylation (HP:0012345)1.98328586
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98328586
60Abnormal protein N-linked glycosylation (HP:0012347)1.98328586
61Autoimmune hemolytic anemia (HP:0001890)1.98264712
62Recurrent fungal infections (HP:0002841)1.97078166
63Ketosis (HP:0001946)1.96499292
64Encephalitis (HP:0002383)1.94978750
65Type 2 muscle fiber atrophy (HP:0003554)1.94807471
66Retinal dysplasia (HP:0007973)1.92084857
67Decreased circulating renin level (HP:0003351)1.89654722
68Chronic otitis media (HP:0000389)1.88403225
69Congenital hepatic fibrosis (HP:0002612)1.87660851
70Cystic liver disease (HP:0006706)1.85398331
71Prolonged QT interval (HP:0001657)1.85017467
72Stomach cancer (HP:0012126)1.84375483
73Albinism (HP:0001022)1.84043870
74Clubbing of toes (HP:0100760)1.83657137
75Eosinophilia (HP:0001880)1.82975878
76Febrile seizures (HP:0002373)1.82566288
77Recurrent viral infections (HP:0004429)1.82047917
783-Methylglutaconic aciduria (HP:0003535)1.80544410
79Azoospermia (HP:0000027)1.79269379
80Polyuria (HP:0000103)1.78289797
81Combined immunodeficiency (HP:0005387)1.77755006
82Pancreatic islet-cell hyperplasia (HP:0004510)1.77097920
83Long clavicles (HP:0000890)1.76007666
84Chronic hepatic failure (HP:0100626)1.73307533
85Nephronophthisis (HP:0000090)1.72400407
86Abnormality of eosinophils (HP:0001879)1.72366319
87Agammaglobulinemia (HP:0004432)1.72017273
88Disproportionate short-trunk short stature (HP:0003521)1.70986616
89Abnormal biliary tract physiology (HP:0012439)1.68774836
90Bile duct proliferation (HP:0001408)1.68774836
91Abnormality of T cell physiology (HP:0011840)1.68041368
92Lissencephaly (HP:0001339)1.67674225
93Abnormality of the renal medulla (HP:0100957)1.66787215
94Neurodegeneration (HP:0002180)1.65669254
95Leukocytosis (HP:0001974)1.65410061
96Abnormality of chromosome stability (HP:0003220)1.63866428
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.63761634
98Medial flaring of the eyebrow (HP:0010747)1.63348112
99Hypoplasia of the thymus (HP:0000778)1.62890840
100Cerebellar dysplasia (HP:0007033)1.62072752

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.59742639
2MAP4K24.49203429
3INSRR4.39483454
4TRIM282.45132854
5NUAK12.40630162
6CCNB12.39054930
7ADRBK22.36579837
8EIF2AK32.32483330
9MAPK132.21170150
10TNIK2.17769289
11TAOK32.13495272
12BCKDK2.12193474
13MAPKAPK52.10684040
14BMPR1B1.88692963
15ACVR1B1.66737068
16ZAK1.63270405
17IRAK31.62555656
18TLK11.60052711
19CAMKK21.44878156
20FER1.39679750
21GRK11.38692965
22PAK31.34460850
23PINK11.32499970
24IKBKB1.30753376
25VRK21.30493649
26IKBKE1.22324854
27MARK31.18033568
28MARK11.17669217
29TRPM71.15425614
30MUSK1.13247854
31MAP3K41.12688716
32MAPKAPK31.10334373
33CASK1.08307335
34WNK31.08148534
35VRK11.07893275
36GRK71.06657886
37TNK21.06297420
38OXSR11.05648005
39CLK11.05589290
40CSNK1G31.01018087
41TEC1.00678455
42DAPK21.00468264
43PIK3CG0.98443839
44TBK10.95003292
45PKN10.92450859
46TXK0.92336493
47IRAK10.91812674
48CSNK1G20.87678062
49CSNK1A1L0.86364271
50CSNK1G10.85974416
51NTRK30.85779966
52MKNK20.84973727
53EPHA40.82784692
54SYK0.82007460
55GRK60.78431833
56KIT0.77135701
57BRSK20.77064720
58MATK0.76864690
59TGFBR20.75307328
60WNK40.74536682
61MKNK10.73982623
62EIF2AK20.70835110
63LYN0.69959047
64CHUK0.69180812
65STK390.62760344
66MAP2K70.56707071
67BLK0.56147858
68TYK20.53337382
69IRAK40.52517663
70PRKCQ0.50324924
71HIPK20.49655012
72PRKCE0.49433500
73PAK60.45177825
74BTK0.43722072
75PRKAA20.42633280
76PIK3CA0.42054846
77MAP4K10.40330133
78BCR0.39718242
79CSNK1A10.39713972
80ABL10.38082976
81ADRBK10.38057483
82STK160.37993370
83MAPK110.37560207
84TAF10.37481940
85BMPR20.36034883
86ERBB30.35349848
87MAP3K140.35158220
88RPS6KB20.34950599
89AKT30.32631409
90GSK3A0.32589722
91ITK0.32464307
92KSR10.31751311
93IGF1R0.31076762
94MST40.30602941
95JAK10.30255725
96PTK2B0.29368580
97CSNK1D0.29249862
98MAP2K10.28534419
99JAK30.28243723
100PRKACA0.27469252

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.47511454
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.99491564
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.68937580
4Allograft rejection_Homo sapiens_hsa053302.63212721
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.56534217
6Phototransduction_Homo sapiens_hsa047442.54514616
7Graft-versus-host disease_Homo sapiens_hsa053322.33670096
8Primary immunodeficiency_Homo sapiens_hsa053402.23828947
9Type I diabetes mellitus_Homo sapiens_hsa049402.16780151
10Autoimmune thyroid disease_Homo sapiens_hsa053202.10266231
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96619868
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91597648
13Nitrogen metabolism_Homo sapiens_hsa009101.84879079
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.71300821
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68093006
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64722040
17Linoleic acid metabolism_Homo sapiens_hsa005911.61584623
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.55900988
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55787010
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.49143413
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48917706
22Ether lipid metabolism_Homo sapiens_hsa005651.46135890
23Staphylococcus aureus infection_Homo sapiens_hsa051501.42572710
24Fanconi anemia pathway_Homo sapiens_hsa034601.39749070
25RNA polymerase_Homo sapiens_hsa030201.39748604
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39279912
27Rheumatoid arthritis_Homo sapiens_hsa053231.34943912
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33712887
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30123934
30Caffeine metabolism_Homo sapiens_hsa002321.27437246
31Sulfur metabolism_Homo sapiens_hsa009201.26251264
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20988231
33Systemic lupus erythematosus_Homo sapiens_hsa053221.18352521
34African trypanosomiasis_Homo sapiens_hsa051431.18126894
35Olfactory transduction_Homo sapiens_hsa047401.18124875
36Homologous recombination_Homo sapiens_hsa034401.15560843
37Selenocompound metabolism_Homo sapiens_hsa004501.13519566
38Hematopoietic cell lineage_Homo sapiens_hsa046401.13207998
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.12631517
40Butanoate metabolism_Homo sapiens_hsa006501.06108314
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.03903864
42Ovarian steroidogenesis_Homo sapiens_hsa049131.03854101
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03344873
44Histidine metabolism_Homo sapiens_hsa003401.02507547
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02166942
46Pertussis_Homo sapiens_hsa051330.99980429
47Taste transduction_Homo sapiens_hsa047420.98328417
48Dorso-ventral axis formation_Homo sapiens_hsa043200.96639095
49Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95065423
50ABC transporters_Homo sapiens_hsa020100.94745427
51Legionellosis_Homo sapiens_hsa051340.89325375
52Leishmaniasis_Homo sapiens_hsa051400.88137676
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.87143941
54Tryptophan metabolism_Homo sapiens_hsa003800.87104688
55Nicotine addiction_Homo sapiens_hsa050330.86938805
56Basal transcription factors_Homo sapiens_hsa030220.86210851
57Influenza A_Homo sapiens_hsa051640.84796196
58Sphingolipid metabolism_Homo sapiens_hsa006000.84180873
59Antigen processing and presentation_Homo sapiens_hsa046120.81342829
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80334923
61Malaria_Homo sapiens_hsa051440.79088282
62Peroxisome_Homo sapiens_hsa041460.74558278
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74398612
64Herpes simplex infection_Homo sapiens_hsa051680.73057982
65Tuberculosis_Homo sapiens_hsa051520.69573959
66Propanoate metabolism_Homo sapiens_hsa006400.69519567
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68799322
68Arachidonic acid metabolism_Homo sapiens_hsa005900.65802974
69RNA degradation_Homo sapiens_hsa030180.65355946
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.64384016
71Chemical carcinogenesis_Homo sapiens_hsa052040.63587734
72Osteoclast differentiation_Homo sapiens_hsa043800.62714035
73Lysosome_Homo sapiens_hsa041420.62146725
74TNF signaling pathway_Homo sapiens_hsa046680.61990300
75Measles_Homo sapiens_hsa051620.59796472
76Salivary secretion_Homo sapiens_hsa049700.58528423
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58246165
78Non-homologous end-joining_Homo sapiens_hsa034500.56842686
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54501556
80Long-term depression_Homo sapiens_hsa047300.51507593
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.50427730
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48582389
83Serotonergic synapse_Homo sapiens_hsa047260.46338158
84Circadian entrainment_Homo sapiens_hsa047130.45353313
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41960736
86Glycerolipid metabolism_Homo sapiens_hsa005610.41417972
87Calcium signaling pathway_Homo sapiens_hsa040200.41389302
88Pyrimidine metabolism_Homo sapiens_hsa002400.39752043
89Glutamatergic synapse_Homo sapiens_hsa047240.38836368
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38492995
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37436262
92Hepatitis C_Homo sapiens_hsa051600.36688946
93Morphine addiction_Homo sapiens_hsa050320.36513777
94Chemokine signaling pathway_Homo sapiens_hsa040620.36223096
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35344593
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34684191
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.34333186
98Dopaminergic synapse_Homo sapiens_hsa047280.33466886
99Regulation of autophagy_Homo sapiens_hsa041400.32568665
100Toxoplasmosis_Homo sapiens_hsa051450.30742454

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