BLK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* B cell receptor signaling pathway (GO:0050853)8.52840287
2positive regulation of gamma-delta T cell activation (GO:0046645)7.36027878
3antigen processing and presentation of endogenous antigen (GO:0019883)7.32192838
4regulation of B cell receptor signaling pathway (GO:0050855)6.98883216
5regulation of B cell differentiation (GO:0045577)6.27567486
6regulation of gamma-delta T cell differentiation (GO:0045586)6.00097516
7B cell proliferation (GO:0042100)5.80612270
8positive regulation of B cell differentiation (GO:0045579)5.78034880
9cellular response to zinc ion (GO:0071294)5.77513918
10regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.51019662
11regulation of gamma-delta T cell activation (GO:0046643)5.49426022
12positive thymic T cell selection (GO:0045059)5.47322950
13cellular response to interleukin-15 (GO:0071350)5.47274845
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.46303531
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.46303531
16CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.23336054
17response to interleukin-15 (GO:0070672)5.13063620
18regulation of interferon-beta biosynthetic process (GO:0045357)4.71367498
19mature B cell differentiation (GO:0002335)4.69197299
20negative regulation of cell killing (GO:0031342)4.46032672
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.46032672
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.43611060
23* antigen receptor-mediated signaling pathway (GO:0050851)4.39653971
24negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.39064566
25positive regulation by symbiont of host defense response (GO:0052509)4.37293612
26modulation by symbiont of host defense response (GO:0052031)4.37293612
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.37293612
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.37293612
29positive regulation by organism of defense response of other organism involved in symbiotic interact4.37293612
30modulation by symbiont of host immune response (GO:0052553)4.37293612
31detection of bacterium (GO:0016045)4.35073277
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.34534135
33regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.30570606
34regulation of B cell proliferation (GO:0030888)4.27222490
35regulation of antigen processing and presentation (GO:0002577)4.23483476
36negative regulation of B cell proliferation (GO:0030889)4.15121258
37detection of other organism (GO:0098543)4.08249096
38thymic T cell selection (GO:0045061)4.04418474
39regulation of B cell apoptotic process (GO:0002902)3.98936283
40positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.91167826
41T cell selection (GO:0045058)3.90112421
42lymph node development (GO:0048535)3.90098092
43B cell activation (GO:0042113)3.88633013
44positive T cell selection (GO:0043368)3.86127411
45* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.82576012
46positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.82378212
47response to type I interferon (GO:0034340)3.80693731
48regulation of interleukin-12 biosynthetic process (GO:0045075)3.80287866
49cellular response to type I interferon (GO:0071357)3.79796910
50type I interferon signaling pathway (GO:0060337)3.79796910
51B cell mediated immunity (GO:0019724)3.77500722
52negative thymic T cell selection (GO:0045060)3.76832535
53negative regulation of phagocytosis (GO:0050765)3.76452680
54defense response to protozoan (GO:0042832)3.73217288
55T cell lineage commitment (GO:0002360)3.72069947
56regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.71778819
57lymphocyte homeostasis (GO:0002260)3.70558275
58negative regulation of histone methylation (GO:0031061)3.69094301
59positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.68857816
60B cell homeostasis (GO:0001782)3.66420663
61production of molecular mediator involved in inflammatory response (GO:0002532)3.66315318
62regulation of alpha-beta T cell proliferation (GO:0046640)3.61586748
63regulation of superoxide anion generation (GO:0032928)3.61515908
64positive regulation of humoral immune response (GO:0002922)3.57043300
65T cell costimulation (GO:0031295)3.56923465
66positive regulation of B cell proliferation (GO:0030890)3.54968979
67tolerance induction (GO:0002507)3.49635895
68lymphocyte costimulation (GO:0031294)3.48789333
69negative T cell selection (GO:0043383)3.48190715
70neutrophil activation (GO:0042119)3.46870131
71positive regulation of Rap GTPase activity (GO:0032854)3.45253727
72lymphocyte proliferation (GO:0046651)3.44789529
73mononuclear cell proliferation (GO:0032943)3.44666481
74T cell homeostasis (GO:0043029)3.41973913
75negative regulation of B cell apoptotic process (GO:0002903)3.41895814
76serine transport (GO:0032329)3.41768641
77interferon-gamma-mediated signaling pathway (GO:0060333)3.40393555
78positive regulation of histone deacetylation (GO:0031065)3.38017536
79regulation of T-helper 1 cell differentiation (GO:0045625)3.37976895
80mature B cell differentiation involved in immune response (GO:0002313)3.37932870
81negative regulation of alpha-beta T cell activation (GO:0046636)3.36968465
82negative regulation of bone resorption (GO:0045779)3.36689280
83positive regulation of B cell activation (GO:0050871)3.33678655
84regulation of B cell activation (GO:0050864)3.31670720
85positive regulation of interferon-alpha production (GO:0032727)3.30813588
86NIK/NF-kappaB signaling (GO:0038061)3.26650528
87negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.24541031
88negative regulation of T-helper cell differentiation (GO:0045623)3.24541031
89T cell migration (GO:0072678)3.23560895
90B cell differentiation (GO:0030183)3.22544529
91regulation of histone H3-K9 methylation (GO:0051570)3.22442720
92response to muramyl dipeptide (GO:0032495)3.21224209
93positive regulation of interleukin-2 production (GO:0032743)3.21202110
94immunoglobulin mediated immune response (GO:0016064)3.20581402
95positive regulation of type 2 immune response (GO:0002830)3.20268754
96leukocyte aggregation (GO:0070486)3.19232504
97regulation of interferon-gamma biosynthetic process (GO:0045072)3.18568892
98leukocyte homeostasis (GO:0001776)3.18503983
99positive regulation of immunoglobulin production (GO:0002639)3.17387045
100detection of external biotic stimulus (GO:0098581)3.14289305
101negative regulation of calcium ion transport into cytosol (GO:0010523)3.14058053
102response to protozoan (GO:0001562)3.13797667
103histone H3-K36 demethylation (GO:0070544)3.12878527
104positive regulation of cell adhesion mediated by integrin (GO:0033630)3.12744251
105regulation of interferon-alpha production (GO:0032647)3.12172304
106negative regulation of lymphocyte mediated immunity (GO:0002707)3.12021335
107Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.11362849
108immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.11362849
109Fc-gamma receptor signaling pathway (GO:0038094)3.11362849
110germinal center formation (GO:0002467)3.08358821
111leukocyte proliferation (GO:0070661)3.07546456
112regulation of T cell receptor signaling pathway (GO:0050856)3.07354482
113Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.06288540
114granulocyte activation (GO:0036230)3.05619283
115JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.03025113
116positive regulation of granulocyte differentiation (GO:0030854)3.02822780
117regulation of dendritic cell antigen processing and presentation (GO:0002604)3.00699113
118cytidine deamination (GO:0009972)3.00628438
119cytidine metabolic process (GO:0046087)3.00628438
120cytidine catabolic process (GO:0006216)3.00628438
121negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.99911489
122macrophage activation involved in immune response (GO:0002281)2.96969099
123T-helper 1 type immune response (GO:0042088)2.96864692
124respiratory burst (GO:0045730)2.94521468
125cellular response to interferon-gamma (GO:0071346)2.94073003
126hepatocyte apoptotic process (GO:0097284)2.91613801
127T cell receptor signaling pathway (GO:0050852)2.91534738
128response to host immune response (GO:0052572)2.90957877
129response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.90957877
130regulation of type I interferon-mediated signaling pathway (GO:0060338)2.90837521
131positive regulation of immunoglobulin mediated immune response (GO:0002891)2.89483224
132positive regulation of B cell mediated immunity (GO:0002714)2.89483224
133positive regulation of antigen processing and presentation (GO:0002579)2.88038975
134regulation of germinal center formation (GO:0002634)2.87459749
135negative regulation of T cell mediated immunity (GO:0002710)2.87347500
136activation of JUN kinase activity (GO:0007257)2.87114531
137natural killer cell differentiation (GO:0001779)2.86686564
138negative regulation of T cell receptor signaling pathway (GO:0050860)2.83583617
139* immune response-activating signal transduction (GO:0002757)2.81537513
140positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.81414048
141regulation of Rap GTPase activity (GO:0032317)2.80892162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.73351105
2MYC_22102868_ChIP-Seq_BL_Human5.09421900
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.66850745
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.50081846
5* SPI1_22096565_ChIP-ChIP_GC-B_Mouse4.15638274
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.70024155
7E2F7_22180533_ChIP-Seq_HELA_Human3.67770451
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.66137130
9VDR_21846776_ChIP-Seq_THP-1_Human3.54552373
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13483591
11* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.08027614
12RUNX_20019798_ChIP-Seq_JUKART_Human2.89325512
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.78683519
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.76993608
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.72098433
16MAF_26560356_Chip-Seq_TH1_Human2.64200916
17MYB_26560356_Chip-Seq_TH1_Human2.59877935
18* MYB_26560356_Chip-Seq_TH2_Human2.55833722
19UTX_26944678_Chip-Seq_JUKART_Human2.51552784
20VDR_24763502_ChIP-Seq_THP-1_Human2.33224040
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.24028441
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.23869178
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22814623
24CIITA_25753668_ChIP-Seq_RAJI_Human2.21429337
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16518941
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12274381
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.12262093
28STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10310104
29* TCF7_22412390_ChIP-Seq_EML_Mouse2.08686980
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.06800884
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04203335
32BP1_19119308_ChIP-ChIP_Hs578T_Human2.02516507
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.01646819
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00448540
35SPI1_23547873_ChIP-Seq_NB4_Human1.98279818
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.90818508
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.90076552
38SCL_19346495_ChIP-Seq_HPC-7_Human1.87961032
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.80587902
40* KDM2B_26808549_Chip-Seq_DND41_Human1.79979346
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.78774089
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76308250
43MAF_26560356_Chip-Seq_TH2_Human1.71869225
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70935392
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67574133
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67362260
47GATA1_22025678_ChIP-Seq_K562_Human1.66923553
48SPI1_23127762_ChIP-Seq_K562_Human1.63087566
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56482173
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54705382
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51807659
52* GATA3_27048872_Chip-Seq_THYMUS_Human1.49749938
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46995270
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44313237
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44196990
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43340460
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41585974
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.41450045
59PU.1_20513432_ChIP-Seq_Bcells_Mouse1.41416362
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39623236
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26137768
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22384016
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21947863
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19228369
65VDR_24787735_ChIP-Seq_THP-1_Human1.17539203
66* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15503032
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12412948
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12038786
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11230020
70PU_27001747_Chip-Seq_BMDM_Mouse1.06626999
71* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06314312
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06073417
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05367890
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04679272
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03983880
76FOXP3_21729870_ChIP-Seq_TREG_Human1.02434770
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02231186
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.02151258
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02017934
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00113478
81GATA3_26560356_Chip-Seq_TH2_Human0.97493456
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95414511
83HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94655557
84KDM2B_26808549_Chip-Seq_JURKAT_Human0.93268837
85LXR_22292898_ChIP-Seq_THP-1_Human0.92393272
86VDR_23849224_ChIP-Seq_CD4+_Human0.92034367
87GATA1_19941827_ChIP-Seq_MEL_Mouse0.91497088
88P300_27268052_Chip-Seq_Bcells_Human0.91184168
89KDM5A_27292631_Chip-Seq_BREAST_Human0.89851309
90NCOR1_26117541_ChIP-Seq_K562_Human0.89329110
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88464652
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86580980
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84693348
94SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84445885
95EZH2_22144423_ChIP-Seq_EOC_Human0.84437148
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83205445
97SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82926844
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.82763535
99SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.81827622
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80589354
101* BCL6_27268052_Chip-Seq_Bcells_Human0.79646621
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79345174
103CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79259403
104GATA1_19941826_ChIP-Seq_K562_Human0.78206478
105CTCF_26484167_Chip-Seq_Bcells_Mouse0.77038306
106CTCF_21964334_ChIP-Seq_BJAB-B_Human0.77013314
107CTCF_27219007_Chip-Seq_ERYTHROID_Human0.74770984
108BCOR_27268052_Chip-Seq_Bcells_Human0.73862557
109FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.73665314
110SA1_27219007_Chip-Seq_ERYTHROID_Human0.73404473
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73204776
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72895864
113FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72437859
114E2F1_21310950_ChIP-Seq_MCF-7_Human0.71153587
115SPI1_20517297_ChIP-Seq_HL60_Human0.70207691
116* SMRT_27268052_Chip-Seq_Bcells_Human0.69997268

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.59241638
2MP0001800_abnormal_humoral_immune5.04773858
3MP0005387_immune_system_phenotype4.98458179
4MP0001790_abnormal_immune_system4.98458179
5MP0000685_abnormal_immune_system4.40448207
6MP0002452_abnormal_antigen_presenting3.76734285
7MP0005000_abnormal_immune_tolerance3.43837401
8MP0003303_peritoneal_inflammation3.34882201
9MP0002723_abnormal_immune_serum3.20983714
10MP0005671_abnormal_response_to3.18273285
11MP0002420_abnormal_adaptive_immunity3.17292348
12MP0001819_abnormal_immune_cell3.06304630
13* MP0002398_abnormal_bone_marrow3.02165623
14* MP0000716_abnormal_immune_system2.74692424
15MP0000689_abnormal_spleen_morphology2.73660450
16MP0003763_abnormal_thymus_physiology2.68459740
17MP0002722_abnormal_immune_system2.33868161
18MP0002166_altered_tumor_susceptibility2.31985979
19* MP0002429_abnormal_blood_cell2.24596248
20MP0005025_abnormal_response_to2.13080414
21MP0001873_stomach_inflammation2.09339712
22MP0002396_abnormal_hematopoietic_system2.08222231
23MP0004510_myositis2.05879926
24MP0009785_altered_susceptibility_to2.05671539
25MP0003300_gastrointestinal_ulcer1.89777297
26MP0002419_abnormal_innate_immunity1.87889238
27MP0002405_respiratory_system_inflammati1.84622219
28MP0000703_abnormal_thymus_morphology1.78628741
29MP0001845_abnormal_inflammatory_respons1.69900352
30MP0002148_abnormal_hypersensitivity_rea1.69226597
31MP0003436_decreased_susceptibility_to1.67909888
32MP0010155_abnormal_intestine_physiology1.67556957
33MP0003724_increased_susceptibility_to1.66140126
34MP0001853_heart_inflammation1.61820683
35MP0004808_abnormal_hematopoietic_stem1.60535735
36MP0004381_abnormal_hair_follicle1.58808668
37MP0004947_skin_inflammation1.58102884
38MP0001348_abnormal_lacrimal_gland1.55303485
39MP0002006_tumorigenesis1.53642787
40MP0003866_abnormal_defecation1.51340657
41MP0010234_abnormal_vibrissa_follicle1.50911248
42MP0008057_abnormal_DNA_replication1.48945682
43MP0002933_joint_inflammation1.47334021
44MP0005310_abnormal_salivary_gland1.35247061
45MP0009333_abnormal_splenocyte_physiolog1.33517310
46MP0003172_abnormal_lysosome_physiology1.30517141
47MP0005464_abnormal_platelet_physiology1.29886199
48MP0003183_abnormal_peptide_metabolism1.27998593
49MP0008260_abnormal_autophagy1.26655790
50MP0000465_gastrointestinal_hemorrhage1.20480319
51MP0002019_abnormal_tumor_incidence1.12643709
52MP0010352_gastrointestinal_tract_polyps1.05780560
53MP0006054_spinal_hemorrhage1.02460494
54MP0002136_abnormal_kidney_physiology1.02012805
55MP0005174_abnormal_tail_pigmentation1.00116285
56MP0001879_abnormal_lymphatic_vessel0.99030544
57MP0002132_abnormal_respiratory_system0.96607082
58MP0003077_abnormal_cell_cycle0.95965022
59MP0002909_abnormal_adrenal_gland0.95017736
60MP0008469_abnormal_protein_level0.94524635
61MP0010094_abnormal_chromosome_stability0.92543061
62MP0005645_abnormal_hypothalamus_physiol0.90524276
63MP0000015_abnormal_ear_pigmentation0.85434209
64MP0003091_abnormal_cell_migration0.85229292
65MP0002928_abnormal_bile_duct0.85068517
66MP0001986_abnormal_taste_sensitivity0.83163351
67MP0008961_abnormal_basal_metabolism0.82841615
68MP0003787_abnormal_imprinting0.82739605
69MP0002095_abnormal_skin_pigmentation0.82399122
70MP0003045_fibrosis0.81906766
71MP0000858_altered_metastatic_potential0.78252547
72MP0008874_decreased_physiological_sensi0.74510028
73MP0005076_abnormal_cell_differentiation0.73098304
74MP0002009_preneoplasia0.70128174
75MP0009278_abnormal_bone_marrow0.69692584
76MP0000372_irregular_coat_pigmentation0.68742638
77MP0002163_abnormal_gland_morphology0.68722068
78MP0002138_abnormal_hepatobiliary_system0.63917418
79MP0002998_abnormal_bone_remodeling0.62383196
80MP0000249_abnormal_blood_vessel0.60420486
81MP0000350_abnormal_cell_proliferation0.60307903
82MP0009764_decreased_sensitivity_to0.59670804
83MP0000490_abnormal_crypts_of0.59266064
84MP0001851_eye_inflammation0.56843717
85MP0003111_abnormal_nucleus_morphology0.56030680
86MP0004883_abnormal_blood_vessel0.55990721
87MP0005621_abnormal_cell_physiology0.54980047
88MP0003191_abnormal_cellular_cholesterol0.53939630
89MP0000767_abnormal_smooth_muscle0.53732894
90MP0001663_abnormal_digestive_system0.52632242
91MP0003453_abnormal_keratinocyte_physiol0.52478856
92MP0000313_abnormal_cell_death0.52299008
93MP0005397_hematopoietic_system_phenotyp0.51801550
94MP0001545_abnormal_hematopoietic_system0.51801550
95MP0003566_abnormal_cell_adhesion0.51552028
96MP0005166_decreased_susceptibility_to0.49426672
97MP0001533_abnormal_skeleton_physiology0.49365867
98MP0003693_abnormal_embryo_hatching0.48624148
99MP0003656_abnormal_erythrocyte_physiolo0.47568215
100MP0003221_abnormal_cardiomyocyte_apopto0.47499071
101MP0006082_CNS_inflammation0.47203700
102MP0005451_abnormal_body_composition0.46848587
103MP0005381_digestive/alimentary_phenotyp0.46689013
104MP0002693_abnormal_pancreas_physiology0.46616204
105MP0009115_abnormal_fat_cell0.46408689
106MP0003828_pulmonary_edema0.46406556
107MP0000569_abnormal_digit_pigmentation0.45292830
108MP0009763_increased_sensitivity_to0.45050471
109MP0002083_premature_death0.44134027
110MP0001730_embryonic_growth_arrest0.43842154
111MP0002168_other_aberrant_phenotype0.42689659
112MP0000609_abnormal_liver_physiology0.42209314
113MP0005379_endocrine/exocrine_gland_phen0.40001972
114MP0000371_diluted_coat_color0.39095660
115MP0005584_abnormal_enzyme/coenzyme_acti0.37971650
116MP0010630_abnormal_cardiac_muscle0.37707628
117MP0001784_abnormal_fluid_regulation0.37320893
118MP0002135_abnormal_kidney_morphology0.37152053
119MP0000477_abnormal_intestine_morphology0.36926883
120MP0005075_abnormal_melanosome_morpholog0.36739967
121MP0003252_abnormal_bile_duct0.35413590
122MP0005384_cellular_phenotype0.34666128

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)9.59512213
2Gastrointestinal stroma tumor (HP:0100723)7.89721242
3Recurrent bronchitis (HP:0002837)6.78257885
4Cellulitis (HP:0100658)6.29390197
5Recurrent sinusitis (HP:0011108)6.10451789
6Papilloma (HP:0012740)5.90997550
7Verrucae (HP:0200043)5.90997550
8Colitis (HP:0002583)5.69414166
9IgM deficiency (HP:0002850)5.53965312
10Lymphopenia (HP:0001888)5.10639021
11Inflammation of the large intestine (HP:0002037)4.91064785
12Emphysema (HP:0002097)4.87600173
13Abnormality of cells of the lymphoid lineage (HP:0012140)4.86137067
14Gastrointestinal inflammation (HP:0004386)4.74484362
15Panhypogammaglobulinemia (HP:0003139)4.74374759
16Recurrent viral infections (HP:0004429)4.72584293
17Meningitis (HP:0001287)4.64677548
18Chronic sinusitis (HP:0011109)4.51459441
19Abnormal delayed hypersensitivity skin test (HP:0002963)4.43981006
20IgA deficiency (HP:0002720)4.24416555
21Abnormality of B cell number (HP:0010975)4.20062585
22B lymphocytopenia (HP:0010976)4.20062585
23Thyroiditis (HP:0100646)4.18425847
24Small epiphyses (HP:0010585)4.18004649
25Vasculitis (HP:0002633)4.06694303
26Recurrent otitis media (HP:0000403)3.96639750
27Chronic otitis media (HP:0000389)3.93071608
28Bronchitis (HP:0012387)3.85010034
29Osteomyelitis (HP:0002754)3.83871294
30Recurrent pneumonia (HP:0006532)3.83692969
31Restrictive lung disease (HP:0002091)3.79353704
32Recurrent lower respiratory tract infections (HP:0002783)3.66665612
33Sepsis (HP:0100806)3.43347243
34Recurrent fungal infections (HP:0002841)3.42396504
35IgG deficiency (HP:0004315)3.39117982
36Recurrent cutaneous fungal infections (HP:0011370)3.38658368
37Chronic mucocutaneous candidiasis (HP:0002728)3.38658368
38Abnormality of macrophages (HP:0004311)3.25310407
39Chronic diarrhea (HP:0002028)3.22255798
40Mitral stenosis (HP:0001718)3.21192703
41T lymphocytopenia (HP:0005403)3.18006026
42Abnormality of T cells (HP:0002843)3.17100219
43Recurrent abscess formation (HP:0002722)3.16084851
44Recurrent bacterial skin infections (HP:0005406)3.08203425
45Abnormality of T cell number (HP:0011839)3.05526323
46Vertebral arch anomaly (HP:0008438)3.02277014
47Abnormality of T cell physiology (HP:0011840)3.02038835
48Abnormality of the fingertips (HP:0001211)2.93286137
49Mediastinal lymphadenopathy (HP:0100721)2.91633161
50Lymphoma (HP:0002665)2.89659563
51Abnormality of the prostate (HP:0008775)2.84154260
52Viral hepatitis (HP:0006562)2.83284341
53Leukopenia (HP:0001882)2.78651236
54Recurrent skin infections (HP:0001581)2.77519857
55Gastrointestinal infarctions (HP:0005244)2.76210036
56Combined immunodeficiency (HP:0005387)2.71111618
57Hypoplasia of the capital femoral epiphysis (HP:0003090)2.64741260
58Flattened epiphyses (HP:0003071)2.61020629
59Severe combined immunodeficiency (HP:0004430)2.60772729
60Urticaria (HP:0001025)2.51652509
61Retrobulbar optic neuritis (HP:0100654)2.51550092
62Optic neuritis (HP:0100653)2.51550092
63Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.39165216
64Skin rash (HP:0000988)2.36460686
65Eczematoid dermatitis (HP:0000976)2.34872790
66Autoimmune thrombocytopenia (HP:0001973)2.30401760
67Nasal polyposis (HP:0100582)2.29754664
68Irregular vertebral endplates (HP:0003301)2.29154113
69Orchitis (HP:0100796)2.28684657
70Abnormality of the pleura (HP:0002103)2.25204387
71Pustule (HP:0200039)2.23853644
72Skin ulcer (HP:0200042)2.23252513
73Encephalitis (HP:0002383)2.21929859
74Neutropenia (HP:0001875)2.21483110
75Pulmonary infiltrates (HP:0002113)2.19444066
76Thrombocytosis (HP:0001894)2.17865521
77Abnormality of the peritoneum (HP:0002585)2.13387609
78Increased IgM level (HP:0003496)2.13226905
79Obstructive lung disease (HP:0006536)2.11338980
80Chronic obstructive pulmonary disease (HP:0006510)2.11338980
81Ulnar bowing (HP:0003031)2.10951393
82Absent epiphyses (HP:0010577)2.08132771
83Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.08132771
84Prolonged bleeding time (HP:0003010)2.08097072
85Interstitial pulmonary disease (HP:0006530)2.06957989
86Abnormality of the intervertebral disk (HP:0005108)2.05914398
87Hemoptysis (HP:0002105)2.05569370
88Abnormality of male internal genitalia (HP:0000022)2.01830996
89Arthralgia (HP:0002829)2.00375772
90Epistaxis (HP:0000421)1.97891269
91Granulocytopenia (HP:0001913)1.97229218
92Gingivitis (HP:0000230)1.96192074
93Spontaneous hematomas (HP:0007420)1.96010348
94Increased IgE level (HP:0003212)1.95716109
95Hypoplasia of the thymus (HP:0000778)1.93266337
96Arthropathy (HP:0003040)1.91414331
97Basal cell carcinoma (HP:0002671)1.88711989
98Pulmonary fibrosis (HP:0002206)1.88357110
99Pulmonary embolism (HP:0002204)1.86828627
100Abnormality of the nasal mucosa (HP:0000433)1.85868467
101Teleangiectasia of the skin (HP:0100585)1.84926355
102Hematochezia (HP:0002573)1.83238502
103Xerostomia (HP:0000217)1.81291937
104Premature loss of primary teeth (HP:0006323)1.80940100
105Slow saccadic eye movements (HP:0000514)1.79412054
106Hypergammaglobulinemia (HP:0010702)1.79349804
107Keratoconjunctivitis sicca (HP:0001097)1.78692705
108Autoimmune hemolytic anemia (HP:0001890)1.78158172
109Deep palmar crease (HP:0006191)1.77063167
110Hepatitis (HP:0012115)1.75814739
111Abnormality of eosinophils (HP:0001879)1.72855492
112Barrel-shaped chest (HP:0001552)1.72568847
113Elevated erythrocyte sedimentation rate (HP:0003565)1.71392185
114Acrocyanosis (HP:0001063)1.70464851
115Abnormality of the vertebral endplates (HP:0005106)1.67964030
116Fatigue (HP:0012378)1.67485408
117Limited elbow extension (HP:0001377)1.66287239
118Papilledema (HP:0001085)1.64298494
119Chest pain (HP:0100749)1.61039341
120Eosinophilia (HP:0001880)1.59027212
121Myositis (HP:0100614)1.57831465
122Facial diplegia (HP:0001349)1.56497818
123Recurrent gram-negative bacterial infections (HP:0005420)1.53667509
124Hypertensive crisis (HP:0100735)1.52107483
125Villous atrophy (HP:0011473)1.50652993
126Abnormality of small intestinal villus morphology (HP:0011472)1.50652993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K17.19311944
2MAP3K104.41697896
3GRK63.90642674
4ERN13.60550649
5PRPF4B3.28268397
6BLK3.07186464
7CSF1R2.89179621
8SYK2.75849217
9BTK2.46016636
10MAP3K132.33094897
11JAK12.30870785
12RIPK42.27477894
13LRRK22.25787067
14STK102.16514474
15SIK22.14955109
16MAP3K141.90769342
17EEF2K1.80504781
18TYK21.70085311
19PASK1.65618500
20BMPR21.65169243
21LYN1.59919471
22CDK121.59358998
23SMG11.48150318
24EIF2AK31.45820864
25ZAP701.42733190
26CSK1.29966895
27MST41.29082259
28ITK1.23269164
29GRK11.20331825
30TBK11.18669933
31MARK31.18231369
32NME21.17441452
33IRAK31.17085289
34SIK31.15351430
35TXK1.14288814
36IKBKB1.13098314
37CLK11.12926043
38KIT1.12116993
39TEC1.09464288
40NEK91.08330121
41SIK11.06149854
42PIM11.02100361
43FES1.01780544
44JAK31.00690969
45LCK0.99987404
46PRKCQ0.96468156
47TNK20.94669385
48IRAK40.94275346
49TRIB30.90815669
50BRD40.90638857
51* HCK0.88202636
52SCYL20.86286014
53TLK10.84494641
54CDK190.82653616
55PRKCH0.78916697
56TESK20.78627664
57NEK20.77118300
58CDC42BPA0.76677390
59CDK40.76435996
60HIPK20.75770533
61STK40.75073944
62TGFBR20.75038876
63FGFR30.73678102
64IKBKE0.72698179
65ALK0.72450352
66IRAK20.71972999
67MATK0.71081404
68PRKD20.70245674
69CDK90.64786189
70MAP3K70.63428116
71MAPK70.61764315
72MELK0.59679090
73CHUK0.59073990
74PKN20.58785110
75MAPK120.58639651
76FGFR40.57984373
77EIF2AK10.55791657
78PDK10.55568204
79PDPK10.53133501
80PRKD10.52609692
81ABL10.52050811
82INSR0.51017797
83DYRK1B0.50903272
84KDR0.48817862
85IRAK10.48154708
86MAP3K10.48085581
87CAMKK10.48047699
88RPS6KA40.47471798
89FYN0.45736853
90MAP2K20.45340769
91WNK10.45003707
92KSR20.44003150
93TAOK20.42336073
94TAOK30.38759652
95MAP2K30.38423178
96MAP3K80.38133228
97ICK0.37825289
98YES10.35953442
99MAP3K110.33495239
100TAOK10.33115885
101FGR0.32443291
102MAPK40.32163261
103NLK0.32097321
104MAPKAPK20.31789042
105STK240.31145382
106RPS6KB20.30472615
107PRKCD0.29767808
108CAMK1G0.28608631
109JAK20.28251134
110EGFR0.27655912
111MARK20.26666203
112SGK20.25592745
113SGK30.25033087
114MAPK110.24430186
115FRK0.24299701
116CSNK1D0.24280649
117PTK60.23295120
118STK110.23001599
119CSNK1A1L0.22631975
120CHEK10.21999743
121CCNB10.21367915
122MAP3K90.20149179
123MAPK30.18776255
124CAMK1D0.18027053
125ATR0.17822605

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.93319960
2B cell receptor signaling pathway_Homo sapiens_hsa046626.32002308
3Autoimmune thyroid disease_Homo sapiens_hsa053203.98311442
4Graft-versus-host disease_Homo sapiens_hsa053323.81397458
5Asthma_Homo sapiens_hsa053103.76194823
6Hematopoietic cell lineage_Homo sapiens_hsa046403.43757101
7Type I diabetes mellitus_Homo sapiens_hsa049403.20795478
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.98906418
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.93354963
10Staphylococcus aureus infection_Homo sapiens_hsa051502.35008362
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.24629789
12Osteoclast differentiation_Homo sapiens_hsa043802.17371286
13Antigen processing and presentation_Homo sapiens_hsa046122.15609699
14T cell receptor signaling pathway_Homo sapiens_hsa046602.09287360
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.90690776
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.89339184
17Leishmaniasis_Homo sapiens_hsa051401.69037370
18Measles_Homo sapiens_hsa051621.58862881
19Base excision repair_Homo sapiens_hsa034101.58639863
20Non-homologous end-joining_Homo sapiens_hsa034501.56750983
21Chemokine signaling pathway_Homo sapiens_hsa040621.56490748
22Herpes simplex infection_Homo sapiens_hsa051681.53023683
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51922441
24Epstein-Barr virus infection_Homo sapiens_hsa051691.35847328
25Tuberculosis_Homo sapiens_hsa051521.28783610
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27065628
27Non-small cell lung cancer_Homo sapiens_hsa052231.25235063
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.22487935
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.19411841
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18980547
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17651453
32Rheumatoid arthritis_Homo sapiens_hsa053231.12257558
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09665030
34Chronic myeloid leukemia_Homo sapiens_hsa052201.09008367
35Ribosome_Homo sapiens_hsa030101.08775912
36Hepatitis B_Homo sapiens_hsa051611.07064317
37Platelet activation_Homo sapiens_hsa046111.06160586
38Viral carcinogenesis_Homo sapiens_hsa052031.04249778
39Apoptosis_Homo sapiens_hsa042101.03976408
40Mismatch repair_Homo sapiens_hsa034301.03477691
41Toxoplasmosis_Homo sapiens_hsa051451.02553509
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99752612
43Neurotrophin signaling pathway_Homo sapiens_hsa047220.98393165
44Acute myeloid leukemia_Homo sapiens_hsa052210.97864663
45Influenza A_Homo sapiens_hsa051640.97484651
46Viral myocarditis_Homo sapiens_hsa054160.96710741
47Shigellosis_Homo sapiens_hsa051310.94925073
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93305659
49Pancreatic cancer_Homo sapiens_hsa052120.92199742
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88990304
51HTLV-I infection_Homo sapiens_hsa051660.85586537
52Systemic lupus erythematosus_Homo sapiens_hsa053220.83406134
53DNA replication_Homo sapiens_hsa030300.83282797
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79220756
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77364729
56VEGF signaling pathway_Homo sapiens_hsa043700.74687461
57Phagosome_Homo sapiens_hsa041450.72991959
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72507660
59African trypanosomiasis_Homo sapiens_hsa051430.70329420
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69143568
61Malaria_Homo sapiens_hsa051440.63765811
62Spliceosome_Homo sapiens_hsa030400.63347642
63Lysine degradation_Homo sapiens_hsa003100.61345881
64FoxO signaling pathway_Homo sapiens_hsa040680.60426843
65Other glycan degradation_Homo sapiens_hsa005110.58719209
66TNF signaling pathway_Homo sapiens_hsa046680.58306642
67Hepatitis C_Homo sapiens_hsa051600.57934844
68MAPK signaling pathway_Homo sapiens_hsa040100.57499590
69MicroRNAs in cancer_Homo sapiens_hsa052060.57303183
70Inositol phosphate metabolism_Homo sapiens_hsa005620.56752203
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56544308
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56250223
73Insulin resistance_Homo sapiens_hsa049310.56226804
74Small cell lung cancer_Homo sapiens_hsa052220.54847795
75Glioma_Homo sapiens_hsa052140.52729253
76Notch signaling pathway_Homo sapiens_hsa043300.51339268
77mTOR signaling pathway_Homo sapiens_hsa041500.46124131
78Endocytosis_Homo sapiens_hsa041440.44773220
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44547089
80Salmonella infection_Homo sapiens_hsa051320.44236612
81p53 signaling pathway_Homo sapiens_hsa041150.44106154
82Colorectal cancer_Homo sapiens_hsa052100.42807209
83Homologous recombination_Homo sapiens_hsa034400.41770179
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.41401261
85GnRH signaling pathway_Homo sapiens_hsa049120.40550569
86Endometrial cancer_Homo sapiens_hsa052130.38910571
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37943685
88Legionellosis_Homo sapiens_hsa051340.36028169
89Prolactin signaling pathway_Homo sapiens_hsa049170.36010894
90Alcoholism_Homo sapiens_hsa050340.35689273
91Allograft rejection_Homo sapiens_hsa053300.34944351
92mRNA surveillance pathway_Homo sapiens_hsa030150.34230029
93Prostate cancer_Homo sapiens_hsa052150.33960503
94Pertussis_Homo sapiens_hsa051330.33802114
95Proteoglycans in cancer_Homo sapiens_hsa052050.32232201
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.31422323
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31224236
98Type II diabetes mellitus_Homo sapiens_hsa049300.30912522
99Renal cell carcinoma_Homo sapiens_hsa052110.30737467
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28673821
101Choline metabolism in cancer_Homo sapiens_hsa052310.27471767
102ErbB signaling pathway_Homo sapiens_hsa040120.25486483
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.23467982
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22567602
105HIF-1 signaling pathway_Homo sapiens_hsa040660.21617226
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21543885
107Long-term potentiation_Homo sapiens_hsa047200.21532017
108RNA degradation_Homo sapiens_hsa030180.21226947
109Fanconi anemia pathway_Homo sapiens_hsa034600.20777616
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20030777
111Nucleotide excision repair_Homo sapiens_hsa034200.19538111
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.19440721
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19041114
114Insulin signaling pathway_Homo sapiens_hsa049100.18261087
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17911016
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17779379
117Dorso-ventral axis formation_Homo sapiens_hsa043200.16710050
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.13708471
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.13667237
120ABC transporters_Homo sapiens_hsa020100.12966316

Most similar genes based on co-expression Upload to Enrichr

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