BLOC1S1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004 [PubMed 15102850]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.04555798
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.03598187
3axon ensheathment in central nervous system (GO:0032291)6.99781820
4central nervous system myelination (GO:0022010)6.99781820
5ATP synthesis coupled proton transport (GO:0015986)6.94240233
6energy coupled proton transport, down electrochemical gradient (GO:0015985)6.94240233
7respiratory electron transport chain (GO:0022904)6.02940801
8electron transport chain (GO:0022900)5.87865247
9fatty acid elongation (GO:0030497)5.11057307
10protein neddylation (GO:0045116)4.73611244
11sequestering of actin monomers (GO:0042989)4.34194627
12regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.11008632
13negative regulation of protein localization to cell surface (GO:2000009)4.09480743
14chaperone-mediated protein transport (GO:0072321)4.07723842
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.91010823
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.91010823
17NADH dehydrogenase complex assembly (GO:0010257)3.91010823
18ribosomal small subunit biogenesis (GO:0042274)3.77568707
19long-chain fatty acid biosynthetic process (GO:0042759)3.76200875
20protein complex biogenesis (GO:0070271)3.68097490
21myelination (GO:0042552)3.67825515
22cytochrome complex assembly (GO:0017004)3.66851663
23ensheathment of neurons (GO:0007272)3.64778456
24axon ensheathment (GO:0008366)3.64778456
25proteasome assembly (GO:0043248)3.60118151
26cholesterol biosynthetic process (GO:0006695)3.59857568
27hydrogen ion transmembrane transport (GO:1902600)3.57146562
28immunoglobulin mediated immune response (GO:0016064)3.55904854
29ATP biosynthetic process (GO:0006754)3.53007128
30purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.47951793
31purine nucleoside triphosphate biosynthetic process (GO:0009145)3.43834315
32deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.35080635
33aldehyde catabolic process (GO:0046185)3.32990181
34proton transport (GO:0015992)3.32701610
35viral transcription (GO:0019083)3.30687280
36response to interferon-beta (GO:0035456)3.30364815
37GTP biosynthetic process (GO:0006183)3.30258118
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.29052151
39hydrogen transport (GO:0006818)3.28060377
40antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.27659220
41cellular response to interferon-beta (GO:0035458)3.24199371
42regulation of mitochondrial translation (GO:0070129)3.23198299
43sterol biosynthetic process (GO:0016126)3.21631761
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.19618831
45termination of RNA polymerase III transcription (GO:0006386)3.19618831
46substantia nigra development (GO:0021762)3.11953189
47isoprenoid biosynthetic process (GO:0008299)3.11933021
48mitochondrial respiratory chain complex assembly (GO:0033108)3.11314460
49positive regulation of antigen processing and presentation (GO:0002579)3.09648208
50translational termination (GO:0006415)3.08305824
51regulation of cellular amino acid metabolic process (GO:0006521)3.08046216
52purine nucleotide salvage (GO:0032261)3.06530340
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04464145
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02260277
55protein targeting to mitochondrion (GO:0006626)3.01561241
56DNA deamination (GO:0045006)3.00886919
57positive regulation of cellular amine metabolic process (GO:0033240)3.00658231
58response to redox state (GO:0051775)2.98562052
59cotranslational protein targeting to membrane (GO:0006613)2.95784652
60establishment of protein localization to mitochondrion (GO:0072655)2.95036668
61translation (GO:0006412)2.93316766
62purine deoxyribonucleotide catabolic process (GO:0009155)2.92907040
63nucleotide transmembrane transport (GO:1901679)2.92438251
64GPI anchor biosynthetic process (GO:0006506)2.91533295
65ribonucleoside triphosphate biosynthetic process (GO:0009201)2.90852879
66ATP hydrolysis coupled proton transport (GO:0015991)2.89534733
67energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.89534733
68DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88934722
69protein targeting to ER (GO:0045047)2.87371931
70creatine metabolic process (GO:0006600)2.84159236
71translational initiation (GO:0006413)2.83956181
72protein targeting to membrane (GO:0006612)2.83740483
73mannosylation (GO:0097502)2.83390926
74amyloid precursor protein metabolic process (GO:0042982)2.82922319
75protein localization to mitochondrion (GO:0070585)2.82556815
76SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.81693751
77establishment of protein localization to mitochondrial membrane (GO:0090151)2.81173616
78regulation of oxidative phosphorylation (GO:0002082)2.80830887
79neutrophil activation involved in immune response (GO:0002283)2.80759450
80cytidine deamination (GO:0009972)2.80574971
81cytidine metabolic process (GO:0046087)2.80574971
82cytidine catabolic process (GO:0006216)2.80574971
83protein localization to endoplasmic reticulum (GO:0070972)2.79169423
84hydrogen peroxide metabolic process (GO:0042743)2.77834513
85cellular response to zinc ion (GO:0071294)2.77498303
86negative regulation of ligase activity (GO:0051352)2.76260490
87negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.76260490
88erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.75214433
89L-phenylalanine catabolic process (GO:0006559)2.75214433
90establishment of protein localization to endoplasmic reticulum (GO:0072599)2.75011653
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74082560
92signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74082560
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73850133
94signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.73242184
95signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.73242184
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.73242184
97B cell mediated immunity (GO:0019724)2.67787015
98dopamine transport (GO:0015872)2.67784025
99GPI anchor metabolic process (GO:0006505)2.67444291
100protein complex disassembly (GO:0043241)2.66738703
101very long-chain fatty acid metabolic process (GO:0000038)2.66390717
102hydrogen peroxide catabolic process (GO:0042744)2.65854973
103limb bud formation (GO:0060174)2.64911785
104purine nucleoside monophosphate biosynthetic process (GO:0009127)2.64852391
105purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.64852391
106deoxyribonucleotide catabolic process (GO:0009264)2.64220255
107purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.61603914
108regulation of antigen processing and presentation (GO:0002577)2.60445986
109oligodendrocyte differentiation (GO:0048709)2.60047794
110maturation of SSU-rRNA (GO:0030490)2.59427711
111negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.59147866
112signal transduction involved in DNA damage checkpoint (GO:0072422)2.57121523
113signal transduction involved in DNA integrity checkpoint (GO:0072401)2.57121523
114purine-containing compound salvage (GO:0043101)2.54021267
115dopamine biosynthetic process (GO:0042416)2.53925900
116regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.53542366
117glutathione derivative biosynthetic process (GO:1901687)2.50573550
118glutathione derivative metabolic process (GO:1901685)2.50573550
119respiratory chain complex IV assembly (GO:0008535)2.43740942
120UTP biosynthetic process (GO:0006228)2.39896947
121amyloid precursor protein catabolic process (GO:0042987)2.39811273
122regulation of collateral sprouting (GO:0048670)2.38376233
123ribosomal small subunit assembly (GO:0000028)2.38272146
124fatty-acyl-CoA metabolic process (GO:0035337)2.37869402
125positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.37613001
126viral life cycle (GO:0019058)2.36683538
127inner mitochondrial membrane organization (GO:0007007)2.36505823
128nucleoside triphosphate biosynthetic process (GO:0009142)2.35665057
129neurotransmitter uptake (GO:0001504)2.35491339
130glycerophospholipid catabolic process (GO:0046475)2.35404676
131cellular protein complex disassembly (GO:0043624)2.34998803
132preassembly of GPI anchor in ER membrane (GO:0016254)2.34425487
133erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.33787205
134L-phenylalanine metabolic process (GO:0006558)2.33787205
135import into cell (GO:0098657)2.32779723
136glutathione metabolic process (GO:0006749)2.31270587
137cofactor catabolic process (GO:0051187)2.29693790
138mitochondrial transport (GO:0006839)2.29017486
139astrocyte development (GO:0014002)2.29014436
140negative regulation of acute inflammatory response (GO:0002674)2.28992196
141translational elongation (GO:0006414)2.28716901
142regulation of dopamine metabolic process (GO:0042053)2.28713595
143regulation of catecholamine metabolic process (GO:0042069)2.28713595
144oxidative phosphorylation (GO:0006119)2.27614017
145long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.26943363
146response to epinephrine (GO:0071871)2.26372724
147cellular response to epinephrine stimulus (GO:0071872)2.25885863
148enteric nervous system development (GO:0048484)2.25135163
149intracellular protein transmembrane import (GO:0044743)2.23141356
150positive regulation of action potential (GO:0045760)2.21858114
151nonribosomal peptide biosynthetic process (GO:0019184)2.21021482
152UTP metabolic process (GO:0046051)2.19670186
153acyl-CoA metabolic process (GO:0006637)2.19508701
154thioester metabolic process (GO:0035383)2.19508701
155lateral sprouting from an epithelium (GO:0060601)2.19258904
156long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.18416107
157glutathione biosynthetic process (GO:0006750)2.18175809
158tissue regeneration (GO:0042246)2.15299727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.43783066
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.54558557
3* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.28691300
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.12252366
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.05230313
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.04397741
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.69707796
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.58886494
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55677239
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32814192
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.24439507
12VDR_22108803_ChIP-Seq_LS180_Human2.23554880
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22978687
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17977035
15FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.17144386
16TAF15_26573619_Chip-Seq_HEK293_Human2.14974098
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14088091
18VDR_23849224_ChIP-Seq_CD4+_Human2.00696814
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.99564314
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99506470
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97951196
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.96863414
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.92985462
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.91878727
25* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90522715
26GBX2_23144817_ChIP-Seq_PC3_Human1.87663355
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86107913
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83066519
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83044279
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.82741975
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82394167
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81945397
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.79665144
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79417539
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.79262924
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.79027148
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76722436
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76511571
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.74019431
40FOXP3_21729870_ChIP-Seq_TREG_Human1.71955487
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70108578
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68918741
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67062866
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65374898
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.64439821
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60478562
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60040376
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.58569419
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58012855
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54667146
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53450097
52* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53042761
53BCL6_27268052_Chip-Seq_Bcells_Human1.49268239
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48477059
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48477059
56CTCF_18555785_ChIP-Seq_MESCs_Mouse1.47252701
57SPI1_23547873_ChIP-Seq_NB4_Human1.46874213
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46389142
59* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46002642
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.43851899
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40766052
62EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.39364028
63* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38792846
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38747117
65EZH2_22144423_ChIP-Seq_EOC_Human1.38636371
66* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37485255
67CTCF_26484167_Chip-Seq_Bcells_Mouse1.37114351
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.36384389
69ER_23166858_ChIP-Seq_MCF-7_Human1.35166366
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32973416
71HTT_18923047_ChIP-ChIP_STHdh_Human1.32460077
72XRN2_22483619_ChIP-Seq_HELA_Human1.31462357
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31129259
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30189774
75IRF1_19129219_ChIP-ChIP_H3396_Human1.28606385
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.27996207
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27893964
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26835118
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26699168
80* ELF1_20517297_ChIP-Seq_JURKAT_Human1.26189244
81BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.26026839
82* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25114709
83* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24731832
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23361424
85P300_19829295_ChIP-Seq_ESCs_Human1.20805791
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20293314
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20293314
88DCP1A_22483619_ChIP-Seq_HELA_Human1.19614390
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.19356230
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18818547
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18739812
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18547635
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18354995
94CTCF_20526341_ChIP-Seq_ESCs_Human1.18271415
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18065714
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17926137
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17875165
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17731068
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17501405
100* ELK1_19687146_ChIP-ChIP_HELA_Human1.17388695
101* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16621118
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15981029
103BCOR_27268052_Chip-Seq_Bcells_Human1.15215262
104IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14653659
105MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14626532
106GABP_19822575_ChIP-Seq_HepG2_Human1.14458549
107POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13951545
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10409703
109FUS_26573619_Chip-Seq_HEK293_Human1.10134510
110SA1_27219007_Chip-Seq_Bcells_Human1.09734737
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09239455
112SRF_21415370_ChIP-Seq_HL-1_Mouse1.06770139
113ERG_20517297_ChIP-Seq_VCAP_Human1.05674336
114STAT1_20625510_ChIP-Seq_HELA_Human1.05366983
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04910472
116POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04645192
117TET1_21451524_ChIP-Seq_MESCs_Mouse1.03855974
118FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03137197
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03073970
120* TTF2_22483619_ChIP-Seq_HELA_Human1.02881462
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02662469
122* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01603442
123P300_27268052_Chip-Seq_Bcells_Human1.01043779
124EST1_17652178_ChIP-ChIP_JURKAT_Human1.00993235
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00116547
126WT1_19549856_ChIP-ChIP_CCG9911_Human0.99963563
127* TAF2_19829295_ChIP-Seq_ESCs_Human0.99384392
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97909101
129TAL1_26923725_Chip-Seq_HPCs_Mouse0.97843697
130RNF2_27304074_Chip-Seq_ESCs_Mouse0.97623971
131* E2F1_20622854_ChIP-Seq_HELA_Human0.96602342
132CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96057823
133CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95500357
134SMAD3_21741376_ChIP-Seq_EPCs_Human0.94918483
135CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94819666
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94306484
137MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94118738
138TP53_18474530_ChIP-ChIP_U2OS_Human0.93874053
139PIAS1_25552417_ChIP-Seq_VCAP_Human0.92795831
140VDR_24763502_ChIP-Seq_THP-1_Human0.92742625
141PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92366250
142* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92341620
143RNF2_27304074_Chip-Seq_NSC_Mouse0.92307613
144TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91290023
145POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90983061
146SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90583428
147LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90396537
148IRF8_27001747_Chip-Seq_BMDM_Mouse0.89977125
149VDR_21846776_ChIP-Seq_THP-1_Human0.89896884
150SOX2_19829295_ChIP-Seq_ESCs_Human0.89843201
151NANOG_19829295_ChIP-Seq_ESCs_Human0.89843201
152CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89830214
153EP300_21415370_ChIP-Seq_HL-1_Mouse0.89524721
154PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89306867
155CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88738175
156CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88585472
157* NANOG_20526341_ChIP-Seq_ESCs_Human0.88066950
158CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87838488
159GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87527917
160RAD21_21589869_ChIP-Seq_MESCs_Mouse0.83867989
161ELK1_22589737_ChIP-Seq_MCF10A_Human0.83736368
162TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82894059
163SA1_22415368_ChIP-Seq_MEFs_Mouse0.81587999
164SMC3_22415368_ChIP-Seq_MEFs_Mouse0.80738998
165MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80559800
166AR_21572438_ChIP-Seq_LNCaP_Human0.79334028
167CREB1_15753290_ChIP-ChIP_HEK293T_Human0.79132243
168PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78097457
169EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.77827646
170PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77774446
171ETV2_25802403_ChIP-Seq_MESCs_Mouse0.77429243
172ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75747665
173EGR1_19032775_ChIP-ChIP_M12_Human0.75719010
174PRDM14_20953172_ChIP-Seq_ESCs_Human0.75420260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.36820391
2MP0009379_abnormal_foot_pigmentation3.31647371
3MP0001905_abnormal_dopamine_level3.13916484
4MP0005671_abnormal_response_to3.13047096
5MP0003136_yellow_coat_color3.07385352
6MP0001529_abnormal_vocalization2.97099183
7MP0001835_abnormal_antigen_presentation2.87870033
8MP0003806_abnormal_nucleotide_metabolis2.41195801
9MP0002139_abnormal_hepatobiliary_system2.34119700
10MP0005058_abnormal_lysosome_morphology2.33321833
11MP0003011_delayed_dark_adaptation2.29288104
12MP0003950_abnormal_plasma_membrane2.23714744
13MP0005451_abnormal_body_composition2.18876671
14MP0002277_abnormal_respiratory_mucosa2.17910835
15MP0003880_abnormal_central_pattern2.15416746
16MP0005171_absent_coat_pigmentation2.10797236
17MP0000685_abnormal_immune_system2.07466113
18MP0005025_abnormal_response_to2.05730218
19MP0005409_darkened_coat_color1.99255101
20MP0003690_abnormal_glial_cell1.97769444
21MP0004142_abnormal_muscle_tone1.93693868
22MP0001790_abnormal_immune_system1.91663438
23MP0005387_immune_system_phenotype1.91663438
24MP0002837_dystrophic_cardiac_calcinosis1.87075091
25MP0004381_abnormal_hair_follicle1.86501391
26MP0009764_decreased_sensitivity_to1.77797666
27MP0001853_heart_inflammation1.76587206
28MP0006276_abnormal_autonomic_nervous1.70902139
29MP0005000_abnormal_immune_tolerance1.70751997
30MP0003186_abnormal_redox_activity1.70078705
31MP0002419_abnormal_innate_immunity1.69717017
32MP0000372_irregular_coat_pigmentation1.68707405
33MP0002653_abnormal_ependyma_morphology1.68420674
34MP0005365_abnormal_bile_salt1.59666981
35MP0003075_altered_response_to1.58815873
36MP0004742_abnormal_vestibular_system1.58521183
37MP0008875_abnormal_xenobiotic_pharmacok1.57214527
38MP0003436_decreased_susceptibility_to1.54191903
39MP0004019_abnormal_vitamin_homeostasis1.53432297
40MP0000749_muscle_degeneration1.52434374
41MP0009840_abnormal_foam_cell1.52285458
42MP0001800_abnormal_humoral_immune1.50955273
43MP0001845_abnormal_inflammatory_respons1.50777835
44MP0005464_abnormal_platelet_physiology1.49959556
45MP0002272_abnormal_nervous_system1.47426065
46MP0002723_abnormal_immune_serum1.47192126
47MP0008469_abnormal_protein_level1.46570313
48MP0002452_abnormal_antigen_presenting1.44350546
49MP0002938_white_spotting1.41392879
50MP0002638_abnormal_pupillary_reflex1.40937682
51MP0001764_abnormal_homeostasis1.40181975
52MP0002876_abnormal_thyroid_physiology1.39317794
53MP0003879_abnormal_hair_cell1.38771258
54MP0002295_abnormal_pulmonary_circulatio1.37179448
55MP0002420_abnormal_adaptive_immunity1.36473882
56MP0003303_peritoneal_inflammation1.35594857
57MP0001819_abnormal_immune_cell1.34744644
58MP0003634_abnormal_glial_cell1.33157226
59MP0009333_abnormal_splenocyte_physiolog1.32942456
60MP0006036_abnormal_mitochondrial_physio1.31424370
61MP0004147_increased_porphyrin_level1.31199661
62MP0010155_abnormal_intestine_physiology1.29762959
63MP0006082_CNS_inflammation1.29124365
64MP0003724_increased_susceptibility_to1.28102974
65MP0005332_abnormal_amino_acid1.25141206
66MP0001440_abnormal_grooming_behavior1.25053249
67MP0005423_abnormal_somatic_nervous1.24696377
68MP0001486_abnormal_startle_reflex1.20896397
69MP0002148_abnormal_hypersensitivity_rea1.19918472
70MP0003329_amyloid_beta_deposits1.18588795
71MP0003866_abnormal_defecation1.17519702
72MP0001485_abnormal_pinna_reflex1.16512735
73MP0004510_myositis1.16512105
74MP0010386_abnormal_urinary_bladder1.16243245
75MP0000566_synostosis1.13627920
76MP0005075_abnormal_melanosome_morpholog1.13295545
77MP0005408_hypopigmentation1.12690488
78MP0000751_myopathy1.11148872
79MP0001346_abnormal_lacrimal_gland1.09970737
80MP0005166_decreased_susceptibility_to1.09494498
81MP0000778_abnormal_nervous_system1.09197685
82MP0001533_abnormal_skeleton_physiology1.08548202
83MP0005551_abnormal_eye_electrophysiolog1.06819915
84MP0001984_abnormal_olfaction1.05935046
85MP0005330_cardiomyopathy1.05522134
86MP0003638_abnormal_response/metabolism_1.05251005
87MP0001663_abnormal_digestive_system1.05244968
88MP0006072_abnormal_retinal_apoptosis1.05093605
89MP0002064_seizures1.04617408
90MP0005319_abnormal_enzyme/_coenzyme1.04048364
91MP0002405_respiratory_system_inflammati1.02702413
92MP0005164_abnormal_response_to1.01346484
93MP0005083_abnormal_biliary_tract1.01047950
94MP0003195_calcinosis1.00891746
95MP0003137_abnormal_impulse_conducting0.99919411
96MP0004043_abnormal_pH_regulation0.99907590
97MP0000026_abnormal_inner_ear0.98625756
98MP0005360_urolithiasis0.98376577
99MP0006035_abnormal_mitochondrial_morpho0.98254639
100MP0009643_abnormal_urine_homeostasis0.98130164
101MP0002736_abnormal_nociception_after0.97828906
102MP0001542_abnormal_bone_strength0.95281206
103MP0004036_abnormal_muscle_relaxation0.94905608
104MP0004134_abnormal_chest_morphology0.93319605
105MP0003172_abnormal_lysosome_physiology0.92999528
106MP0009250_abnormal_appendicular_skeleto0.92948543
107MP0009745_abnormal_behavioral_response0.92328176
108MP0002734_abnormal_mechanical_nocicepti0.91640612
109MP0000716_abnormal_immune_system0.91131277
110MP0005085_abnormal_gallbladder_physiolo0.90657356
111MP0001756_abnormal_urination0.90590862
112MP0001970_abnormal_pain_threshold0.88679127
113MP0003938_abnormal_ear_development0.87263037
114MP0001873_stomach_inflammation0.86142128
115MP0001727_abnormal_embryo_implantation0.84789189
116MP0005584_abnormal_enzyme/coenzyme_acti0.84777282
117MP0002229_neurodegeneration0.84110197
118MP0009697_abnormal_copulation0.83786854
119MP0009763_increased_sensitivity_to0.83402740
120MP0000762_abnormal_tongue_morphology0.82771882
121MP0008438_abnormal_cutaneous_collagen0.81814577
122MP0001963_abnormal_hearing_physiology0.81656675
123MP0003191_abnormal_cellular_cholesterol0.80789599
124MP0002972_abnormal_cardiac_muscle0.80167565
125MP0004270_analgesia0.79647110
126MP0002693_abnormal_pancreas_physiology0.79515971
127MP0002933_joint_inflammation0.78394500
128MP0002752_abnormal_somatic_nervous0.78223870
129MP0004883_abnormal_blood_vessel0.77788511
130MP0000343_altered_response_to0.77725798
131MP0005167_abnormal_blood-brain_barrier0.76482926
132MP0005381_digestive/alimentary_phenotyp0.75761070
133MP0003878_abnormal_ear_physiology0.75649260
134MP0005377_hearing/vestibular/ear_phenot0.75649260
135MP0005636_abnormal_mineral_homeostasis0.74887665
136MP0002132_abnormal_respiratory_system0.73905184
137MP0000230_abnormal_systemic_arterial0.73839422
138MP0002138_abnormal_hepatobiliary_system0.73563522
139MP0005595_abnormal_vascular_smooth0.73544439
140MP0000490_abnormal_crypts_of0.73280531
141MP0001661_extended_life_span0.73043391
142MP0001968_abnormal_touch/_nociception0.72954036
143MP0002102_abnormal_ear_morphology0.72856190
144MP0005379_endocrine/exocrine_gland_phen0.72490525
145MP0008872_abnormal_physiological_respon0.72376584
146MP0005620_abnormal_muscle_contractility0.72220194
147MP0002822_catalepsy0.72030615
148MP0002254_reproductive_system_inflammat0.71477210
149MP0000689_abnormal_spleen_morphology0.71444363
150MP0005084_abnormal_gallbladder_morpholo0.71395059
151MP0005253_abnormal_eye_physiology0.71278797
152MP0005535_abnormal_body_temperature0.70418514
153MP0009765_abnormal_xenobiotic_induced0.70345571
154MP0009785_altered_susceptibility_to0.69828017
155MP0002332_abnormal_exercise_endurance0.69687984
156MP0002163_abnormal_gland_morphology0.69066394
157MP0002067_abnormal_sensory_capabilities0.68988785
158MP0005410_abnormal_fertilization0.68423910
159MP0002572_abnormal_emotion/affect_behav0.67372542
160MP0003632_abnormal_nervous_system0.67260798
161MP0005165_increased_susceptibility_to0.66117137
162MP0005503_abnormal_tendon_morphology0.65996864

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.25369855
2Abnormal mitochondria in muscle tissue (HP:0008316)5.43539366
3Acute encephalopathy (HP:0006846)5.35575540
4Mitochondrial inheritance (HP:0001427)5.28962930
5Progressive macrocephaly (HP:0004481)5.26144734
6Renal Fanconi syndrome (HP:0001994)4.58375403
7Hepatocellular necrosis (HP:0001404)4.33339326
8Increased CSF lactate (HP:0002490)4.30205447
9Increased hepatocellular lipid droplets (HP:0006565)4.25626510
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.14859013
11Parakeratosis (HP:0001036)4.08005577
12Lipid accumulation in hepatocytes (HP:0006561)3.99407314
13Hepatic necrosis (HP:0002605)3.94273549
14Cerebral edema (HP:0002181)3.91178820
153-Methylglutaconic aciduria (HP:0003535)3.87759349
16Increased serum pyruvate (HP:0003542)3.74362577
17Abnormality of glycolysis (HP:0004366)3.74362577
18Leukodystrophy (HP:0002415)3.72338736
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.54644154
20Increased intramyocellular lipid droplets (HP:0012240)3.39195716
21Respiratory failure (HP:0002878)3.35590775
22Optic disc pallor (HP:0000543)3.30742783
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.25181356
24Neurofibrillary tangles (HP:0002185)3.08268702
25Exercise intolerance (HP:0003546)3.07847845
26Increased muscle lipid content (HP:0009058)3.07105257
27Congenital ichthyosiform erythroderma (HP:0007431)2.99978254
28Abnormality of renal resorption (HP:0011038)2.98803016
29Abnormality of liposaccharide metabolism (HP:0010968)2.94539966
30Abnormality of glycosphingolipid metabolism (HP:0004343)2.94539966
31Abnormality of glycolipid metabolism (HP:0010969)2.94539966
32Sensory axonal neuropathy (HP:0003390)2.92005110
33Elevated erythrocyte sedimentation rate (HP:0003565)2.90867529
34Vacuolated lymphocytes (HP:0001922)2.90440124
35Exertional dyspnea (HP:0002875)2.90409407
36Lactic acidosis (HP:0003128)2.82321517
37Systemic lupus erythematosus (HP:0002725)2.72035116
38Abnormality of macrophages (HP:0004311)2.71071717
39Abnormality of cells of the erythroid lineage (HP:0012130)2.68401043
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.62633529
41Degeneration of the lateral corticospinal tracts (HP:0002314)2.62633529
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.55420953
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.55420953
44Nasal polyposis (HP:0100582)2.52198767
45X-linked dominant inheritance (HP:0001423)2.46243384
46Abnormality of urine glucose concentration (HP:0011016)2.44081744
47Glycosuria (HP:0003076)2.44081744
48Abnormality of the nasal mucosa (HP:0000433)2.41586490
49Petechiae (HP:0000967)2.37566124
50Increased serum lactate (HP:0002151)2.33340177
51Aplastic anemia (HP:0001915)2.33095402
52Nausea (HP:0002018)2.32872311
53Recurrent abscess formation (HP:0002722)2.32549426
54Abnormality of the axillary hair (HP:0100134)2.30419884
55Abnormality of secondary sexual hair (HP:0009888)2.30419884
56Chronic obstructive pulmonary disease (HP:0006510)2.29854515
57Obstructive lung disease (HP:0006536)2.29854515
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29351492
59Hypothermia (HP:0002045)2.29202066
60Recurrent bacterial skin infections (HP:0005406)2.28187006
61Chronic sinusitis (HP:0011109)2.22145114
62Cerebral hemorrhage (HP:0001342)2.21764672
63Muscle fiber atrophy (HP:0100295)2.20763398
64Muscle hypertrophy of the lower extremities (HP:0008968)2.19950224
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19641069
66Patchy hypopigmentation of hair (HP:0011365)2.18481342
67Partial duplication of thumb phalanx (HP:0009944)2.17456235
68Recurrent gram-negative bacterial infections (HP:0005420)2.14382769
69Chronic otitis media (HP:0000389)2.14093901
70Respiratory difficulties (HP:0002880)2.13837915
71Abnormal number of erythroid precursors (HP:0012131)2.13157135
72Lethargy (HP:0001254)2.10569033
73Macrocytic anemia (HP:0001972)2.08289505
74Renal tubular dysfunction (HP:0000124)2.06675774
75Methylmalonic acidemia (HP:0002912)2.06488045
76Stenosis of the external auditory canal (HP:0000402)2.04728118
77Abnormal ciliary motility (HP:0012262)2.04677604
78Abnormality of aromatic amino acid family metabolism (HP:0004338)2.04337576
79Calf muscle hypertrophy (HP:0008981)2.01859387
80Progressive neurologic deterioration (HP:0002344)1.99710461
81Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.99497262
82Amniotic constriction ring (HP:0009775)1.98061950
83Abnormality of placental membranes (HP:0011409)1.98061950
84Hypoplastic left heart (HP:0004383)1.96788986
85Hypomagnesemia (HP:0002917)1.96436086
86Oral leukoplakia (HP:0002745)1.96002277
87White forelock (HP:0002211)1.95310785
88Peripheral hypomyelination (HP:0007182)1.94986072
89Increased IgM level (HP:0003496)1.94931403
90Purpura (HP:0000979)1.94896801
91Muscle fiber splitting (HP:0003555)1.94149122
92Spastic paraparesis (HP:0002313)1.93787062
93Stomatitis (HP:0010280)1.93302211
94Type I transferrin isoform profile (HP:0003642)1.90383774
95Congenital, generalized hypertrichosis (HP:0004540)1.90009081
96Pulmonary artery stenosis (HP:0004415)1.89853252
97Hepatosplenomegaly (HP:0001433)1.88914515
98Hyperphosphaturia (HP:0003109)1.88420276
99Erythroderma (HP:0001019)1.87182462
100Eczematoid dermatitis (HP:0000976)1.85685180
101Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85372673
102Pallor (HP:0000980)1.85342035
103Abnormal hemoglobin (HP:0011902)1.85235753
104Partial duplication of the phalanx of hand (HP:0009999)1.84610547
105IgM deficiency (HP:0002850)1.84355900
106Abnormal urine phosphate concentration (HP:0012599)1.82377936
107Emotional lability (HP:0000712)1.81036664
108Abnormality of the phalanges of the 2nd finger (HP:0009541)1.79818223
109CNS demyelination (HP:0007305)1.79193622
110Neuroendocrine neoplasm (HP:0100634)1.77937002
111Aplasia involving bones of the extremities (HP:0009825)1.77800056
112Aplasia involving bones of the upper limbs (HP:0009823)1.77800056
113Aplasia of the phalanges of the hand (HP:0009802)1.77800056
114Increased cerebral lipofuscin (HP:0011813)1.75287665
115Cerebral inclusion bodies (HP:0100314)1.74323290
116Increased serum ferritin (HP:0003281)1.73989652
117Prolonged neonatal jaundice (HP:0006579)1.73328100
118Abnormality of magnesium homeostasis (HP:0004921)1.72046639
119Axonal loss (HP:0003447)1.71846318
120Degeneration of anterior horn cells (HP:0002398)1.71409641
121Abnormality of the anterior horn cell (HP:0006802)1.71409641
122Methylmalonic aciduria (HP:0012120)1.70664966
123Mutism (HP:0002300)1.69957448
124Nasolacrimal duct obstruction (HP:0000579)1.69805365
125Pheochromocytoma (HP:0002666)1.68855601
126Vomiting (HP:0002013)1.68206971
127Cerebral palsy (HP:0100021)1.67659619
128Myokymia (HP:0002411)1.67327601
129Abnormal pupillary function (HP:0007686)1.66994815
130Hypoplastic heart (HP:0001961)1.66429955
131Reticulocytopenia (HP:0001896)1.65151485
132Meningitis (HP:0001287)1.64673362
133Gliosis (HP:0002171)1.63803348
134Metaphyseal dysplasia (HP:0100255)1.63524141
135Metabolic alkalosis (HP:0200114)1.62542944
136Pancytopenia (HP:0001876)1.61427222
137Mediastinal lymphadenopathy (HP:0100721)1.60954676
138Generalized aminoaciduria (HP:0002909)1.60542816
139Increased neuronal autofluorescent lipopigment (HP:0002074)1.59577843
140Dicarboxylic aciduria (HP:0003215)1.58850373
141Abnormality of dicarboxylic acid metabolism (HP:0010995)1.58850373
142Abnormal respiratory motile cilium physiology (HP:0012261)1.58057672
143Abnormal respiratory motile cilium morphology (HP:0005938)1.57122171
144Abnormal respiratory epithelium morphology (HP:0012253)1.57122171
145Infantile muscular hypotonia (HP:0008947)1.55056111
146Blindness (HP:0000618)1.53723863
147Recurrent skin infections (HP:0001581)1.53252148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.57942686
2STK394.43211867
3PBK3.24031773
4OXSR12.97748959
5TLK12.95540010
6NME22.83157900
7MST42.54412249
8TESK12.50488719
9MYLK2.47162695
10BCR2.42966562
11TNIK2.23920339
12MAP3K112.23690282
13WNK42.12781357
14PKN12.07965820
15STK162.07084590
16LIMK11.92817939
17CASK1.89305481
18MAPKAPK51.87544958
19MUSK1.85613322
20ARAF1.69742860
21BMPR1B1.64940131
22NME11.63798663
23GRK71.59338307
24BCKDK1.47551984
25EPHB11.47201812
26PIM21.45328590
27ADRBK21.43877412
28MAP4K11.43552664
29RIPK41.43158847
30PINK11.41503020
31OBSCN1.39651460
32ROCK21.38555389
33CSNK1G31.36779866
34CDK191.31185431
35LRRK21.27139884
36DYRK21.25029114
37IRAK21.20804083
38MET1.20380853
39TAOK21.20139665
40MAP4K21.19039108
41CAMK2B1.18914826
42TAOK11.12603882
43TBK11.08545790
44TYK21.08431251
45CAMK2D1.08039035
46UHMK11.05989141
47TNK21.03753552
48PHKG11.03663654
49PHKG21.03663654
50CSNK1G11.02680800
51BLK1.02423117
52SYK1.00250821
53CAMK2G0.98967487
54DAPK10.94758985
55NUAK10.92126565
56LYN0.91787895
57MST1R0.91595158
58CSK0.91357948
59ABL20.90523029
60ILK0.90144481
61GRK50.89965481
62FGR0.89001709
63FGFR20.88106366
64PRKCQ0.87017626
65BMPR20.86910225
66MAP3K120.86689892
67WNK10.86371662
68CAMK2A0.84821786
69TIE10.84704834
70PRKCE0.84627784
71MAPK150.82725898
72CSNK1G20.81869361
73PRKG20.81124625
74GRK10.80315871
75RPS6KA50.79953307
76IKBKE0.79271964
77TGFBR20.78626725
78FES0.78467764
79CSNK1A1L0.76821030
80KIT0.76796475
81PDK20.76719383
82INSRR0.76060186
83TRPM70.74502707
84MAPK130.73104075
85ADRBK10.72826402
86ZAP700.71812967
87DAPK30.71140497
88GRK60.69526964
89NEK60.69464130
90VRK10.68163100
91PAK30.67044869
92MAPKAPK30.65785398
93KDR0.64978765
94ROCK10.64137973
95MOS0.62338518
96WNK30.62088899
97MAP2K30.60486094
98IRAK40.60120130
99PAK10.59366798
100PTK2B0.59174149
101MARK10.58702353
102YES10.57927071
103MAP3K30.57233133
104BUB10.57021201
105CLK10.56908048
106MAPK120.56505772
107TESK20.56427811
108PIK3CA0.54994864
109PRKACA0.54931917
110MAP2K60.54264646
111TXK0.54216740
112PRKD10.54018844
113ERN10.53699245
114CSF1R0.52769624
115MAPK40.52291591
116PRPF4B0.50810394
117AURKA0.50723316
118EIF2AK10.50234928
119EPHB20.50198151
120BTK0.49253841
121CSNK2A10.48872946
122IRAK10.48611806
123ZAK0.47857598
124SGK4940.46754295
125SGK2230.46754295
126EPHA40.45027963
127PAK40.44739071
128DAPK20.44266057
129PRKG10.44153467
130TEC0.44060123
131CCNB10.43915870
132ERBB40.43754773
133LCK0.41621632
134CDK140.41130106
135ACVR1B0.39710997
136NTRK10.39483973
137MATK0.39475394
138PIK3CG0.39294246
139PIM10.39189948
140ITK0.38805810
141PRKCA0.38733379
142PASK0.38502908
143PRKCG0.38118288
144IKBKB0.38089390
145CSNK2A20.38085851
146DYRK30.37933902
147PNCK0.37114294
148STK100.36647552
149PRKACB0.36394575
150MAP2K20.36299308
151PRKCD0.35939701

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.40010045
2Parkinsons disease_Homo sapiens_hsa050124.53486344
3Alzheimers disease_Homo sapiens_hsa050103.45193308
4Fatty acid elongation_Homo sapiens_hsa000623.23691377
5Ribosome_Homo sapiens_hsa030103.11748018
6Huntingtons disease_Homo sapiens_hsa050163.00180561
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.00062698
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.88698249
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.78302506
10Steroid biosynthesis_Homo sapiens_hsa001002.47211020
11Protein export_Homo sapiens_hsa030602.33286999
12Cardiac muscle contraction_Homo sapiens_hsa042602.23819378
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02938233
14Sulfur metabolism_Homo sapiens_hsa009201.99499592
15Proteasome_Homo sapiens_hsa030501.96977698
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83529855
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61332254
18Propanoate metabolism_Homo sapiens_hsa006401.53953533
19Histidine metabolism_Homo sapiens_hsa003401.53662675
20Ether lipid metabolism_Homo sapiens_hsa005651.52909321
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52302146
22Type I diabetes mellitus_Homo sapiens_hsa049401.52041923
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46331169
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44607581
25Peroxisome_Homo sapiens_hsa041461.42874986
26Chemical carcinogenesis_Homo sapiens_hsa052041.40514390
27Antigen processing and presentation_Homo sapiens_hsa046121.38901826
28RNA polymerase_Homo sapiens_hsa030201.35172950
29Glutathione metabolism_Homo sapiens_hsa004801.33677962
30Butanoate metabolism_Homo sapiens_hsa006501.29608608
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26209201
32Arachidonic acid metabolism_Homo sapiens_hsa005901.22711108
33Linoleic acid metabolism_Homo sapiens_hsa005911.22449242
34Tyrosine metabolism_Homo sapiens_hsa003501.21954737
35Collecting duct acid secretion_Homo sapiens_hsa049661.19268664
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12558465
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08474179
38Fatty acid metabolism_Homo sapiens_hsa012121.05095793
39Retinol metabolism_Homo sapiens_hsa008301.03532347
40Rheumatoid arthritis_Homo sapiens_hsa053231.02415240
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.00087923
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00031841
43Mismatch repair_Homo sapiens_hsa034300.98945803
44Homologous recombination_Homo sapiens_hsa034400.96145723
45Arginine and proline metabolism_Homo sapiens_hsa003300.95811471
46Phenylalanine metabolism_Homo sapiens_hsa003600.95210691
47Fatty acid degradation_Homo sapiens_hsa000710.92523219
48Graft-versus-host disease_Homo sapiens_hsa053320.88646061
49Metabolic pathways_Homo sapiens_hsa011000.87994618
50Autoimmune thyroid disease_Homo sapiens_hsa053200.87688244
51Lysosome_Homo sapiens_hsa041420.86375085
52Pyruvate metabolism_Homo sapiens_hsa006200.86207695
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85352629
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.82821694
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82278440
56DNA replication_Homo sapiens_hsa030300.82016152
57Systemic lupus erythematosus_Homo sapiens_hsa053220.81232365
58Other glycan degradation_Homo sapiens_hsa005110.80779759
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80176752
60Sphingolipid metabolism_Homo sapiens_hsa006000.78481924
61Base excision repair_Homo sapiens_hsa034100.77563109
62Hematopoietic cell lineage_Homo sapiens_hsa046400.75538418
63Leishmaniasis_Homo sapiens_hsa051400.74653589
64Vitamin B6 metabolism_Homo sapiens_hsa007500.73570699
65PPAR signaling pathway_Homo sapiens_hsa033200.71416692
66Tryptophan metabolism_Homo sapiens_hsa003800.68699804
67Allograft rejection_Homo sapiens_hsa053300.66313587
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66167417
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.65094388
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64890445
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61991393
72beta-Alanine metabolism_Homo sapiens_hsa004100.60057699
73Caffeine metabolism_Homo sapiens_hsa002320.60037174
74Vibrio cholerae infection_Homo sapiens_hsa051100.59428268
75Fructose and mannose metabolism_Homo sapiens_hsa000510.59070514
76Malaria_Homo sapiens_hsa051440.57761819
77Folate biosynthesis_Homo sapiens_hsa007900.55335139
78Viral myocarditis_Homo sapiens_hsa054160.54633014
79Complement and coagulation cascades_Homo sapiens_hsa046100.53350626
80Phagosome_Homo sapiens_hsa041450.50427680
81Pertussis_Homo sapiens_hsa051330.50200641
82Serotonergic synapse_Homo sapiens_hsa047260.49813181
83Sulfur relay system_Homo sapiens_hsa041220.49735572
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49182346
85Tuberculosis_Homo sapiens_hsa051520.48864878
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48387606
87Asthma_Homo sapiens_hsa053100.48305919
88Galactose metabolism_Homo sapiens_hsa000520.45327065
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43778822
90Synaptic vesicle cycle_Homo sapiens_hsa047210.42805233
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42479471
92Staphylococcus aureus infection_Homo sapiens_hsa051500.40589632
93Spliceosome_Homo sapiens_hsa030400.38851462
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37544998
95Nucleotide excision repair_Homo sapiens_hsa034200.36750973
96Phototransduction_Homo sapiens_hsa047440.35469562
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35384461
98Nitrogen metabolism_Homo sapiens_hsa009100.34769014
99Salmonella infection_Homo sapiens_hsa051320.34398345
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32986798
101Mineral absorption_Homo sapiens_hsa049780.32449390
102Axon guidance_Homo sapiens_hsa043600.32424792
103Carbon metabolism_Homo sapiens_hsa012000.31686185
104Osteoclast differentiation_Homo sapiens_hsa043800.31634300
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31352251
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29568136
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29324222
108Pyrimidine metabolism_Homo sapiens_hsa002400.28735149
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28515463
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.27909511
111Vitamin digestion and absorption_Homo sapiens_hsa049770.27142500
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24820022
113Purine metabolism_Homo sapiens_hsa002300.23332811
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22793188
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.20786988
116Dilated cardiomyopathy_Homo sapiens_hsa054140.18828844
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18400716
118Starch and sucrose metabolism_Homo sapiens_hsa005000.17263568
119Fatty acid biosynthesis_Homo sapiens_hsa000610.16685162
120African trypanosomiasis_Homo sapiens_hsa051430.15422752
121GABAergic synapse_Homo sapiens_hsa047270.13914946
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.12851380
123Regulation of autophagy_Homo sapiens_hsa041400.12543711
124Fat digestion and absorption_Homo sapiens_hsa049750.12244566
125Ovarian steroidogenesis_Homo sapiens_hsa049130.09201590
126Glycerolipid metabolism_Homo sapiens_hsa005610.08857580
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.07496429
128Primary immunodeficiency_Homo sapiens_hsa053400.07461524
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.07213199

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