BLOC1S2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with multiple functions. The encoded protein has been found in association with the centrosome, shown to co-localize with gamma-tubulin, and also found to be one of the proteins in the BLOC-1 complex which functions in the formation of lysosome-related organelles. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.57820653
2ribosomal small subunit assembly (GO:0000028)5.57240447
3DNA deamination (GO:0045006)5.18604741
4protein neddylation (GO:0045116)5.13835107
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.12349026
6ATP synthesis coupled proton transport (GO:0015986)4.93168623
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.93168623
8mitochondrial respiratory chain complex I assembly (GO:0032981)4.82360069
9NADH dehydrogenase complex assembly (GO:0010257)4.82360069
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.82360069
11respiratory electron transport chain (GO:0022904)4.58918918
12protein complex biogenesis (GO:0070271)4.58632528
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.56917886
14electron transport chain (GO:0022900)4.52036313
15maturation of SSU-rRNA (GO:0030490)4.46920432
16formation of translation preinitiation complex (GO:0001731)4.37082963
17telomere maintenance via semi-conservative replication (GO:0032201)4.36110832
18DNA strand elongation involved in DNA replication (GO:0006271)4.34182914
19respiratory chain complex IV assembly (GO:0008535)4.25621495
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.20735658
21mitochondrial respiratory chain complex assembly (GO:0033108)4.20047968
22ribosomal small subunit biogenesis (GO:0042274)4.18813757
23proteasome assembly (GO:0043248)4.16555618
24viral transcription (GO:0019083)4.11955294
25DNA strand elongation (GO:0022616)4.10572099
26translational termination (GO:0006415)4.03795507
27telomere maintenance via recombination (GO:0000722)3.95272018
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.93214133
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.91382248
30nucleobase biosynthetic process (GO:0046112)3.84288778
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.84128364
32DNA replication initiation (GO:0006270)3.82998802
33anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.82519942
34DNA replication checkpoint (GO:0000076)3.81714159
35negative regulation of ligase activity (GO:0051352)3.79987357
36negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.79987357
37chaperone-mediated protein transport (GO:0072321)3.79687819
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.77598381
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.77598381
40ribosomal large subunit biogenesis (GO:0042273)3.77314467
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.77015876
42purine nucleobase biosynthetic process (GO:0009113)3.76876955
43signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.75574560
44signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.75574560
45signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.75574560
46sequestering of actin monomers (GO:0042989)3.74740271
47cotranslational protein targeting to membrane (GO:0006613)3.70133519
48translational elongation (GO:0006414)3.68681434
49cullin deneddylation (GO:0010388)3.68434825
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.68216436
51protein targeting to ER (GO:0045047)3.65127661
52signal transduction involved in DNA integrity checkpoint (GO:0072401)3.65113869
53signal transduction involved in DNA damage checkpoint (GO:0072422)3.65113869
54regulation of cellular amino acid metabolic process (GO:0006521)3.64407523
55ribonucleoprotein complex biogenesis (GO:0022613)3.62546802
56hydrogen ion transmembrane transport (GO:1902600)3.61843588
57mitotic recombination (GO:0006312)3.61490723
58translational initiation (GO:0006413)3.61196250
59protein-cofactor linkage (GO:0018065)3.60373590
60signal transduction involved in cell cycle checkpoint (GO:0072395)3.59267991
61CENP-A containing nucleosome assembly (GO:0034080)3.58396736
62protein deneddylation (GO:0000338)3.56153371
63termination of RNA polymerase III transcription (GO:0006386)3.54694632
64transcription elongation from RNA polymerase III promoter (GO:0006385)3.54694632
65cytochrome complex assembly (GO:0017004)3.51716516
66protein localization to endoplasmic reticulum (GO:0070972)3.49644770
67antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.49114255
68telomere maintenance via telomere lengthening (GO:0010833)3.46714245
69chromatin remodeling at centromere (GO:0031055)3.44572831
70spliceosomal snRNP assembly (GO:0000387)3.44427684
71establishment of protein localization to endoplasmic reticulum (GO:0072599)3.44383753
72positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.43173305
73energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.43103265
74ATP hydrolysis coupled proton transport (GO:0015991)3.43103265
75proton transport (GO:0015992)3.43024143
767-methylguanosine mRNA capping (GO:0006370)3.42468349
77translation (GO:0006412)3.42218387
78ribosome biogenesis (GO:0042254)3.41177069
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.39652948
80nucleotide-excision repair, DNA gap filling (GO:0006297)3.39106837
81hydrogen transport (GO:0006818)3.38686826
82transcription-coupled nucleotide-excision repair (GO:0006283)3.38017756
83rRNA processing (GO:0006364)3.36952907
847-methylguanosine RNA capping (GO:0009452)3.36075756
85RNA capping (GO:0036260)3.36075756
86rRNA modification (GO:0000154)3.34351379
87behavioral response to nicotine (GO:0035095)3.33933244
88cellular protein complex disassembly (GO:0043624)3.30738692
89positive regulation of ligase activity (GO:0051351)3.29550474
90G1/S transition of mitotic cell cycle (GO:0000082)3.29087796
91cell cycle G1/S phase transition (GO:0044843)3.29087796
92nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.28044181
93viral life cycle (GO:0019058)3.27271302
94rRNA metabolic process (GO:0016072)3.23191775
95pseudouridine synthesis (GO:0001522)3.21204689
96L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.19345818
97organelle disassembly (GO:1903008)3.17931515
98mitotic metaphase plate congression (GO:0007080)3.17661988
99ribosome assembly (GO:0042255)3.13552564
100water-soluble vitamin biosynthetic process (GO:0042364)3.13455572
101signal peptide processing (GO:0006465)3.13413035
102* platelet dense granule organization (GO:0060155)3.12304369
103DNA damage response, detection of DNA damage (GO:0042769)3.12078642
104protein localization to cilium (GO:0061512)3.10853054
105kinetochore assembly (GO:0051382)3.10595914
106kinetochore organization (GO:0051383)3.10461654
107exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10218807
108DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.10033203
109preassembly of GPI anchor in ER membrane (GO:0016254)3.07176253
110nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05489057
111positive regulation of cell cycle arrest (GO:0071158)3.04187891
112cellular component biogenesis (GO:0044085)3.02638169
113regulation of ubiquitin-protein transferase activity (GO:0051438)3.02152068
114establishment of integrated proviral latency (GO:0075713)3.01957918
115nucleobase-containing small molecule interconversion (GO:0015949)3.01578836
116transcription from RNA polymerase I promoter (GO:0006360)2.99945097
117regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.99819199
118regulation of mitotic spindle checkpoint (GO:1903504)2.99819199
119viral mRNA export from host cell nucleus (GO:0046784)2.96876808
120DNA replication-independent nucleosome organization (GO:0034724)2.96833785
121DNA replication-independent nucleosome assembly (GO:0006336)2.96833785
122deoxyribonucleotide biosynthetic process (GO:0009263)2.95496494
123spliceosomal complex assembly (GO:0000245)2.94454777
124kynurenine metabolic process (GO:0070189)2.94139255
125termination of RNA polymerase I transcription (GO:0006363)2.92695998
126regulation of ligase activity (GO:0051340)2.92520478
127protein complex disassembly (GO:0043241)2.91416539
128DNA double-strand break processing (GO:0000729)2.90948838
129protein targeting to mitochondrion (GO:0006626)2.89801882
130establishment of protein localization to mitochondrion (GO:0072655)2.89375682
131protein localization to mitochondrion (GO:0070585)2.88007648
132ribonucleoprotein complex disassembly (GO:0032988)2.87442466
133transcription elongation from RNA polymerase I promoter (GO:0006362)2.86854771
134mannosylation (GO:0097502)2.86564738
135negative regulation of mast cell activation (GO:0033004)2.86020932
136ATP biosynthetic process (GO:0006754)2.85778973
137antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.85405893
138negative regulation of membrane potential (GO:0045837)2.84091261
139L-methionine salvage (GO:0071267)2.84023670
140L-methionine biosynthetic process (GO:0071265)2.84023670
141amino acid salvage (GO:0043102)2.84023670
142protein localization to kinetochore (GO:0034501)2.83540015
143macromolecular complex disassembly (GO:0032984)2.82785331
144establishment of chromosome localization (GO:0051303)2.82439158
145intracellular protein transmembrane import (GO:0044743)2.82030178
146adenosine metabolic process (GO:0046085)2.81947407
147purine nucleoside triphosphate biosynthetic process (GO:0009145)2.81715477
148RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81668296
149tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81668296
150negative regulation of telomere maintenance (GO:0032205)2.78932581
151purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.76092885
152tryptophan catabolic process (GO:0006569)2.71148549
153indole-containing compound catabolic process (GO:0042436)2.71148549
154indolalkylamine catabolic process (GO:0046218)2.71148549
155C-terminal protein amino acid modification (GO:0018410)2.66156120
156C-terminal protein lipidation (GO:0006501)2.64534914
157GPI anchor metabolic process (GO:0006505)2.64487764
158tRNA processing (GO:0008033)2.63858117
159histone mRNA metabolic process (GO:0008334)2.62701483
160positive regulation of mitochondrial fission (GO:0090141)2.52648660
161mitochondrial transport (GO:0006839)2.51566992
162regulation of cellular amine metabolic process (GO:0033238)2.49939223
163aldehyde catabolic process (GO:0046185)2.48966148
164GPI anchor biosynthetic process (GO:0006506)2.48827179
165peptidyl-histidine modification (GO:0018202)2.46730957
166GTP biosynthetic process (GO:0006183)2.45420270
167oxidative phosphorylation (GO:0006119)2.44377905
168detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.42012163

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.12365863
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.25609850
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.01143460
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.79408375
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.79097611
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.69166015
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53072513
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.28125851
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.20259306
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.08193854
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03282915
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96844373
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.95741500
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.94658861
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86237767
16ZNF274_21170338_ChIP-Seq_K562_Hela2.84889856
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80986969
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.76556787
19VDR_22108803_ChIP-Seq_LS180_Human2.72663257
20VDR_23849224_ChIP-Seq_CD4+_Human2.59976553
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.58891229
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57776742
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51655590
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48918856
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39712254
26XRN2_22483619_ChIP-Seq_HELA_Human2.37511266
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25614238
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24978885
29DCP1A_22483619_ChIP-Seq_HELA_Human2.23679279
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23083474
31FOXM1_23109430_ChIP-Seq_U2OS_Human2.22770240
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21526584
33FOXP3_21729870_ChIP-Seq_TREG_Human2.20608050
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.19509933
35FLI1_27457419_Chip-Seq_LIVER_Mouse2.16857569
36IGF1R_20145208_ChIP-Seq_DFB_Human2.15446019
37TAF15_26573619_Chip-Seq_HEK293_Human2.14559232
38ELK1_19687146_ChIP-ChIP_HELA_Human2.10745434
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09101012
40* GABP_19822575_ChIP-Seq_HepG2_Human2.06665808
41FUS_26573619_Chip-Seq_HEK293_Human2.05049963
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03854211
43* SRF_21415370_ChIP-Seq_HL-1_Mouse1.99383843
44EWS_26573619_Chip-Seq_HEK293_Human1.97527688
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97204252
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.96485309
47TTF2_22483619_ChIP-Seq_HELA_Human1.92679174
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91629628
49P300_19829295_ChIP-Seq_ESCs_Human1.89540838
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87886113
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87368270
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83881311
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.83618962
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83061131
55GBX2_23144817_ChIP-Seq_PC3_Human1.82975531
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81466173
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75907677
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71217848
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70728260
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70726571
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70500491
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68718736
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61580039
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58723554
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58457905
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58110779
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55430894
68TP53_22573176_ChIP-Seq_HFKS_Human1.55202686
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54869738
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53414053
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.48810227
72CIITA_25753668_ChIP-Seq_RAJI_Human1.47640613
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45985721
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45379751
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44561714
76NANOG_19829295_ChIP-Seq_ESCs_Human1.43845726
77SOX2_19829295_ChIP-Seq_ESCs_Human1.43845726
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41661977
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40821758
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.40126144
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39105966
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37243435
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34423752
84AR_21909140_ChIP-Seq_LNCAP_Human1.33619731
85ER_23166858_ChIP-Seq_MCF-7_Human1.33597702
86IRF1_19129219_ChIP-ChIP_H3396_Human1.31374005
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.30094173
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29925180
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29853330
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.29853330
91SPI1_23547873_ChIP-Seq_NB4_Human1.29693094
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27982004
93KDM5A_27292631_Chip-Seq_BREAST_Human1.26046790
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.25987478
95ELK1_22589737_ChIP-Seq_MCF10A_Human1.25178335
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23986699
97* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21792677
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21683593
99IRF8_21731497_ChIP-ChIP_J774_Mouse1.20001672
100PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18938301
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.18785140
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18639705
103TFEB_21752829_ChIP-Seq_HELA_Human1.15085468
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14944452
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14849383
106CRX_20693478_ChIP-Seq_RETINA_Mouse1.14810031
107CBP_20019798_ChIP-Seq_JUKART_Human1.12620751
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12620751
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11641191
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11591914
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09705696
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08556455
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08087627
114NOTCH1_21737748_ChIP-Seq_TLL_Human1.07387858
115BCAT_22108803_ChIP-Seq_LS180_Human1.06690605
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05427932
117EZH2_22144423_ChIP-Seq_EOC_Human1.04867406
118MYC_18940864_ChIP-ChIP_HL60_Human1.04281331
119* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04122197
120AR_20517297_ChIP-Seq_VCAP_Human1.03491609
121POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03356396
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03028283
123FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02803128
124KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01256008
125AR_25329375_ChIP-Seq_VCAP_Human0.99897024
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99339838
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98876495
128NANOG_18555785_Chip-Seq_ESCs_Mouse0.98532368
129NCOR_22424771_ChIP-Seq_293T_Human0.98200871
130KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98180862
131STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97558732
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97158947
133STAT3_18555785_Chip-Seq_ESCs_Mouse0.97068552
134TCF4_22108803_ChIP-Seq_LS180_Human0.96781155
135P53_22387025_ChIP-Seq_ESCs_Mouse0.96487878
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95700726
137SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95522563
138BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95321370
139JUN_21703547_ChIP-Seq_K562_Human0.95194696
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94492996
141CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94353723
142KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94031333
143MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93155489
144KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92999339
145HTT_18923047_ChIP-ChIP_STHdh_Human0.92676323
146EGR1_19374776_ChIP-ChIP_THP-1_Human0.92174654
147AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92023603
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91741816
149ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90915763
150CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90472085
151P300_18555785_Chip-Seq_ESCs_Mouse0.90292620
152CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90219617
153TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90022359
154* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89847355
155SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89007004
156SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88784302
157MYC_22102868_ChIP-Seq_BL_Human0.88361104
158HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87408629
159RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84697841
160KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82785305
161RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81596420
162DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81424479
163STAT4_19710469_ChIP-ChIP_TH1__Mouse0.78267748
164CTCF_18555785_ChIP-Seq_MESCs_Mouse0.76509544
165SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.75742414
166OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75689093
167CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74510938
168DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73714270
169VDR_21846776_ChIP-Seq_THP-1_Human0.72598159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.30789061
2MP0004957_abnormal_blastocyst_morpholog4.27636280
3MP0010094_abnormal_chromosome_stability4.06270206
4MP0003077_abnormal_cell_cycle3.76163939
5MP0003111_abnormal_nucleus_morphology3.70810267
6MP0008057_abnormal_DNA_replication3.39478454
7MP0008058_abnormal_DNA_repair3.26538703
8MP0008007_abnormal_cellular_replicative2.98269221
9MP0002396_abnormal_hematopoietic_system2.98110245
10MP0003880_abnormal_central_pattern2.78965111
11MP0001835_abnormal_antigen_presentation2.69411600
12MP0003011_delayed_dark_adaptation2.65530701
13MP0008932_abnormal_embryonic_tissue2.48625283
14MP0003195_calcinosis2.36040604
15MP0002736_abnormal_nociception_after2.33831424
16MP0006072_abnormal_retinal_apoptosis2.30777267
17MP0002102_abnormal_ear_morphology2.30065656
18MP0003786_premature_aging2.22347537
19MP0009046_muscle_twitch2.22208974
20MP0008877_abnormal_DNA_methylation2.18403771
21MP0005084_abnormal_gallbladder_morpholo2.08913546
22MP0001968_abnormal_touch/_nociception2.05219100
23MP0003186_abnormal_redox_activity2.04673241
24MP0009745_abnormal_behavioral_response1.94212066
25MP0000569_abnormal_digit_pigmentation1.94032957
26MP0005253_abnormal_eye_physiology1.92847357
27MP0009333_abnormal_splenocyte_physiolog1.92607896
28MP0005551_abnormal_eye_electrophysiolog1.92166766
29MP0002837_dystrophic_cardiac_calcinosis1.90942303
30MP0000490_abnormal_crypts_of1.88081077
31MP0009785_altered_susceptibility_to1.85255032
32MP0005671_abnormal_response_to1.84880457
33MP0001984_abnormal_olfaction1.83561396
34MP0002638_abnormal_pupillary_reflex1.79819544
35MP0003806_abnormal_nucleotide_metabolis1.78153154
36MP0001545_abnormal_hematopoietic_system1.75413572
37MP0005397_hematopoietic_system_phenotyp1.75413572
38MP0002090_abnormal_vision1.75305987
39MP0002398_abnormal_bone_marrow1.74887850
40MP0010386_abnormal_urinary_bladder1.74692263
41MP0000350_abnormal_cell_proliferation1.73266626
42MP0001853_heart_inflammation1.71136778
43MP0004142_abnormal_muscle_tone1.70706710
44MP0001486_abnormal_startle_reflex1.67786607
45MP0002272_abnormal_nervous_system1.66511362
46MP0002132_abnormal_respiratory_system1.65486528
47MP0002735_abnormal_chemical_nociception1.63155271
48MP0001730_embryonic_growth_arrest1.62270402
49MP0003763_abnormal_thymus_physiology1.60383124
50MP0002148_abnormal_hypersensitivity_rea1.59698032
51MP0003718_maternal_effect1.58658454
52MP0000685_abnormal_immune_system1.58200006
53MP0000689_abnormal_spleen_morphology1.57277028
54MP0009379_abnormal_foot_pigmentation1.55142923
55MP0002019_abnormal_tumor_incidence1.53492302
56MP0004808_abnormal_hematopoietic_stem1.53338033
57MP0001800_abnormal_humoral_immune1.51919203
58MP0000313_abnormal_cell_death1.51662588
59MP0006276_abnormal_autonomic_nervous1.51565405
60MP0004742_abnormal_vestibular_system1.51056455
61MP0002722_abnormal_immune_system1.51033651
62MP0001819_abnormal_immune_cell1.50583857
63MP0002420_abnormal_adaptive_immunity1.50527380
64MP0005075_abnormal_melanosome_morpholog1.47896428
65MP0000858_altered_metastatic_potential1.47666893
66MP0000716_abnormal_immune_system1.46051626
67MP0002452_abnormal_antigen_presenting1.45785611
68MP0005379_endocrine/exocrine_gland_phen1.45526116
69MP0001986_abnormal_taste_sensitivity1.45256314
70MP0008875_abnormal_xenobiotic_pharmacok1.45047586
71MP0009764_decreased_sensitivity_to1.43788095
72MP0006082_CNS_inflammation1.43160335
73MP0002429_abnormal_blood_cell1.41902067
74MP0002064_seizures1.41576607
75MP0003123_paternal_imprinting1.41503960
76MP0008872_abnormal_physiological_respon1.41065507
77MP0010352_gastrointestinal_tract_polyps1.40352223
78MP0002723_abnormal_immune_serum1.39402222
79MP0002277_abnormal_respiratory_mucosa1.39369193
80MP0003787_abnormal_imprinting1.37313140
81MP0005000_abnormal_immune_tolerance1.34064884
82MP0005645_abnormal_hypothalamus_physiol1.33981516
83MP0003436_decreased_susceptibility_to1.33869671
84MP0005025_abnormal_response_to1.32093496
85MP0006035_abnormal_mitochondrial_morpho1.32017019
86MP0002572_abnormal_emotion/affect_behav1.31681488
87MP0000427_abnormal_hair_cycle1.29061196
88MP0001440_abnormal_grooming_behavior1.28527955
89MP0000703_abnormal_thymus_morphology1.27753311
90MP0010307_abnormal_tumor_latency1.26612670
91MP0002734_abnormal_mechanical_nocicepti1.25420012
92MP0005174_abnormal_tail_pigmentation1.25201741
93MP0004885_abnormal_endolymph1.24025499
94MP0006292_abnormal_olfactory_placode1.23028205
95MP0002405_respiratory_system_inflammati1.21438343
96MP0001501_abnormal_sleep_pattern1.21197140
97MP0001970_abnormal_pain_threshold1.21050040
98MP0006036_abnormal_mitochondrial_physio1.20969633
99MP0001529_abnormal_vocalization1.20530644
100MP0000647_abnormal_sebaceous_gland1.18622130
101MP0002160_abnormal_reproductive_system1.16167921
102MP0000358_abnormal_cell_content/1.16144456
103MP0005646_abnormal_pituitary_gland1.14920948
104MP0005423_abnormal_somatic_nervous1.14823464
105MP0000516_abnormal_urinary_system1.12124847
106MP0005367_renal/urinary_system_phenotyp1.12124847
107MP0005167_abnormal_blood-brain_barrier1.10746988
108MP0002080_prenatal_lethality1.10116642
109MP0001697_abnormal_embryo_size1.09732213
110MP0002095_abnormal_skin_pigmentation1.09574193
111MP0000015_abnormal_ear_pigmentation1.08903520
112MP0003635_abnormal_synaptic_transmissio1.07676675
113MP0002419_abnormal_innate_immunity1.06874515
114MP0002067_abnormal_sensory_capabilities1.06058845
115MP0008995_early_reproductive_senescence1.05892305
116MP0002210_abnormal_sex_determination1.03491112
117MP0002063_abnormal_learning/memory/cond0.99912515
118MP0002733_abnormal_thermal_nociception0.98368479
119MP0003567_abnormal_fetal_cardiomyocyte0.96637144
120MP0005387_immune_system_phenotype0.95400333
121MP0001790_abnormal_immune_system0.95400333
122MP0002751_abnormal_autonomic_nervous0.95029508
123MP0005380_embryogenesis_phenotype0.94128524
124MP0001672_abnormal_embryogenesis/_devel0.94128524
125MP0003122_maternal_imprinting0.93467432
126MP0003121_genomic_imprinting0.93082990
127MP0002163_abnormal_gland_morphology0.92905337
128MP0005195_abnormal_posterior_eye0.92050142
129MP0005386_behavior/neurological_phenoty0.91857103
130MP0004924_abnormal_behavior0.91857103
131MP0001145_abnormal_male_reproductive0.91193247
132MP0005085_abnormal_gallbladder_physiolo0.90182779
133MP0002229_neurodegeneration0.90002687
134MP0001324_abnormal_eye_pigmentation0.88570860
135MP0003315_abnormal_perineum_morphology0.88290518
136MP0001485_abnormal_pinna_reflex0.87051818
137MP0002557_abnormal_social/conspecific_i0.86625168
138MP0001542_abnormal_bone_strength0.86601568
139MP0001919_abnormal_reproductive_system0.86463185
140MP0004215_abnormal_myocardial_fiber0.85037859
141MP0001929_abnormal_gametogenesis0.84325738
142MP0005389_reproductive_system_phenotype0.83625934
143MP0002928_abnormal_bile_duct0.81703620
144MP0004133_heterotaxia0.81480373
145MP0003984_embryonic_growth_retardation0.79658832
146MP0002876_abnormal_thyroid_physiology0.79544866
147MP0002752_abnormal_somatic_nervous0.78844370
148MP0002234_abnormal_pharynx_morphology0.78791555
149MP0000372_irregular_coat_pigmentation0.78304525
150MP0000465_gastrointestinal_hemorrhage0.76783263
151MP0002909_abnormal_adrenal_gland0.76520359
152MP0002938_white_spotting0.76358995
153MP0001845_abnormal_inflammatory_respons0.76155791
154MP0003866_abnormal_defecation0.75948639
155MP0008789_abnormal_olfactory_epithelium0.75550626
156MP0002088_abnormal_embryonic_growth/wei0.75257203
157MP0005384_cellular_phenotype0.74327744
158MP0010155_abnormal_intestine_physiology0.73764219
159MP0009697_abnormal_copulation0.73610284
160MP0004270_analgesia0.73025095
161MP0000343_altered_response_to0.72997396
162MP0003633_abnormal_nervous_system0.72876377
163MP0000653_abnormal_sex_gland0.72741296
164MP0001873_stomach_inflammation0.72279372
165MP0001764_abnormal_homeostasis0.71975606
166MP0002006_tumorigenesis0.71076219
167MP0002085_abnormal_embryonic_tissue0.70875418
168MP0008260_abnormal_autophagy0.70783859
169MP0005464_abnormal_platelet_physiology0.70529289
170MP0000681_abnormal_thyroid_gland0.70273382
171MP0001905_abnormal_dopamine_level0.67959819
172MP0002166_altered_tumor_susceptibility0.67324940
173MP0004147_increased_porphyrin_level0.66278053
174MP0005266_abnormal_metabolism0.66059532
175MP0001119_abnormal_female_reproductive0.63980489

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.84284651
2Birth length less than 3rd percentile (HP:0003561)4.75338565
3Abnormality of cells of the erythroid lineage (HP:0012130)4.62489396
4Abnormal number of erythroid precursors (HP:0012131)4.50421056
5Aplastic anemia (HP:0001915)4.03933254
6Abnormality of the anterior horn cell (HP:0006802)3.58635161
7Degeneration of anterior horn cells (HP:0002398)3.58635161
8Breast hypoplasia (HP:0003187)3.58620852
9Cerebral hypomyelination (HP:0006808)3.36593349
10Oral leukoplakia (HP:0002745)3.24006635
11Chromsome breakage (HP:0040012)3.20861878
12Pancreatic cysts (HP:0001737)3.20052023
13Macrocytic anemia (HP:0001972)3.13998732
14Rough bone trabeculation (HP:0100670)3.09560917
15Hepatocellular necrosis (HP:0001404)3.09016910
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.07392433
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.07392433
183-Methylglutaconic aciduria (HP:0003535)3.06386563
19Type I transferrin isoform profile (HP:0003642)3.06126166
20Mitochondrial inheritance (HP:0001427)2.99985881
21Thrombocytosis (HP:0001894)2.99785998
22Abnormality of midbrain morphology (HP:0002418)2.99688387
23Molar tooth sign on MRI (HP:0002419)2.99688387
24Pallor (HP:0000980)2.95352897
25Carpal bone hypoplasia (HP:0001498)2.92620223
26Cerebral edema (HP:0002181)2.92510663
27Type II lissencephaly (HP:0007260)2.86827194
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.83810668
29Exertional dyspnea (HP:0002875)2.82704052
30Acute necrotizing encephalopathy (HP:0006965)2.82465645
3111 pairs of ribs (HP:0000878)2.82243737
32Medial flaring of the eyebrow (HP:0010747)2.79016498
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.77763851
34Increased CSF lactate (HP:0002490)2.76391632
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75650233
36Optic disc pallor (HP:0000543)2.72666260
37Pancreatic fibrosis (HP:0100732)2.71879501
38Generalized aminoaciduria (HP:0002909)2.71730240
39Increased serum lactate (HP:0002151)2.71223586
40Increased hepatocellular lipid droplets (HP:0006565)2.69143068
41True hermaphroditism (HP:0010459)2.68079520
42Agnosia (HP:0010524)2.65020952
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.61219489
44Absent thumb (HP:0009777)2.60989470
45Poor head control (HP:0002421)2.59968903
46Hepatic necrosis (HP:0002605)2.57350893
47Abnormal mitochondria in muscle tissue (HP:0008316)2.55184721
48Abnormality of the preputium (HP:0100587)2.54964067
49Respiratory failure (HP:0002878)2.54643316
50Premature graying of hair (HP:0002216)2.54021479
51Colon cancer (HP:0003003)2.53891103
52Type 2 muscle fiber atrophy (HP:0003554)2.50383954
53Abnormality of glycolysis (HP:0004366)2.46788636
54Increased serum pyruvate (HP:0003542)2.46788636
55Methylmalonic acidemia (HP:0002912)2.45425643
56Congenital, generalized hypertrichosis (HP:0004540)2.45293400
57IgM deficiency (HP:0002850)2.45180358
58Muscle fiber atrophy (HP:0100295)2.43349158
59Elevated erythrocyte sedimentation rate (HP:0003565)2.42847787
60Patellar aplasia (HP:0006443)2.41043835
61Bone marrow hypocellularity (HP:0005528)2.40425524
62Gait imbalance (HP:0002141)2.39035134
63Mutism (HP:0002300)2.38454844
64Meckel diverticulum (HP:0002245)2.37740377
65Leukodystrophy (HP:0002415)2.36611642
66Pancytopenia (HP:0001876)2.36400821
67Nephrogenic diabetes insipidus (HP:0009806)2.35165519
68Abnormal trabecular bone morphology (HP:0100671)2.34651268
69Abolished electroretinogram (ERG) (HP:0000550)2.34517105
70Reduced antithrombin III activity (HP:0001976)2.32046692
71Congenital primary aphakia (HP:0007707)2.31135427
72CNS demyelination (HP:0007305)2.29921611
73Aplasia/Hypoplasia of the patella (HP:0006498)2.29478504
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28369511
75Abnormality of alanine metabolism (HP:0010916)2.28369511
76Hyperalaninemia (HP:0003348)2.28369511
77Abnormality of the ileum (HP:0001549)2.28256422
78Abnormality of chromosome stability (HP:0003220)2.27186777
79Cellular immunodeficiency (HP:0005374)2.26273740
80Microretrognathia (HP:0000308)2.25719666
81Retinal dysplasia (HP:0007973)2.25063512
82Inability to walk (HP:0002540)2.23940268
83Myelodysplasia (HP:0002863)2.23900975
84Lipid accumulation in hepatocytes (HP:0006561)2.22789086
85Atrophy/Degeneration involving motor neurons (HP:0007373)2.19490077
86Pulmonary fibrosis (HP:0002206)2.17943684
87Microvesicular hepatic steatosis (HP:0001414)2.17410253
88Postnatal microcephaly (HP:0005484)2.17324072
89Polyphagia (HP:0002591)2.15702063
90Progressive macrocephaly (HP:0004481)2.15031760
91Lymphoma (HP:0002665)2.14691649
92Tongue fasciculations (HP:0001308)2.13118023
93Abnormality of glycolipid metabolism (HP:0010969)2.11651065
94Abnormality of liposaccharide metabolism (HP:0010968)2.11651065
95Abnormality of glycosphingolipid metabolism (HP:0004343)2.11651065
96Horseshoe kidney (HP:0000085)2.11114258
97Congenital stationary night blindness (HP:0007642)2.11069632
98Decreased electroretinogram (ERG) amplitude (HP:0000654)2.08315082
99Methylmalonic aciduria (HP:0012120)2.08145531
100Cleft eyelid (HP:0000625)2.07127129
101Lethargy (HP:0001254)2.06483655
102Hypothermia (HP:0002045)2.06106605
103Respiratory difficulties (HP:0002880)2.05546949
104Abnormality of the labia minora (HP:0012880)2.05395421
105Increased intramyocellular lipid droplets (HP:0012240)2.04537386
106Constricted visual fields (HP:0001133)2.04154383
107Trismus (HP:0000211)2.03967158
108CNS hypomyelination (HP:0003429)2.03444589
109Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03047245
110Abnormal protein N-linked glycosylation (HP:0012347)2.03047245
111Abnormal protein glycosylation (HP:0012346)2.03047245
112Abnormal glycosylation (HP:0012345)2.03047245
113Duplicated collecting system (HP:0000081)2.01784676
114Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01566498
115Febrile seizures (HP:0002373)1.99688021
116Acute encephalopathy (HP:0006846)1.99023498
117Aplasia/Hypoplasia of the uvula (HP:0010293)1.98952608
118Renal Fanconi syndrome (HP:0001994)1.98026917
119Abnormality of the renal collecting system (HP:0004742)1.97891566
120IgG deficiency (HP:0004315)1.97771649
121Petechiae (HP:0000967)1.96893619
122Lissencephaly (HP:0001339)1.96863184
123Nephronophthisis (HP:0000090)1.96706363
124Abnormality of serum amino acid levels (HP:0003112)1.95046003
125Exercise intolerance (HP:0003546)1.94835303
126Amyotrophic lateral sclerosis (HP:0007354)1.94813274
127Asplenia (HP:0001746)1.93720841
128Secondary amenorrhea (HP:0000869)1.92691874
129Atonic seizures (HP:0010819)1.92591055
130Recurrent abscess formation (HP:0002722)1.92393414
131Sclerocornea (HP:0000647)1.92282305
132Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92063403
133Neoplasm of the pancreas (HP:0002894)1.90196451
134Optic nerve coloboma (HP:0000588)1.89678140
135Irregular epiphyses (HP:0010582)1.88798810
136Parakeratosis (HP:0001036)1.87912532
137Lactic acidosis (HP:0003128)1.87841032
138X-linked dominant inheritance (HP:0001423)1.87771809
139Absent radius (HP:0003974)1.87751242
140Premature ovarian failure (HP:0008209)1.86567958
141Genital tract atresia (HP:0001827)1.85923127
142Prolonged neonatal jaundice (HP:0006579)1.83459827
143Stenosis of the external auditory canal (HP:0000402)1.82535855
144Renal cortical cysts (HP:0000803)1.82319426
145Pendular nystagmus (HP:0012043)1.81971212
146Neutropenia (HP:0001875)1.81967580
147Vaginal atresia (HP:0000148)1.81416484
148Dialeptic seizures (HP:0011146)1.77658440
149Vacuolated lymphocytes (HP:0001922)1.76422778
150Progressive inability to walk (HP:0002505)1.76171582
151Emotional lability (HP:0000712)1.74815021
152Increased muscle lipid content (HP:0009058)1.73219497
153Stomatitis (HP:0010280)1.72463046
154Bile duct proliferation (HP:0001408)1.72161407
155Abnormal biliary tract physiology (HP:0012439)1.72161407
156Blindness (HP:0000618)1.71165564
157Muscular hypotonia of the trunk (HP:0008936)1.70718594
158Abnormality of the renal cortex (HP:0011035)1.70713394
159Limb dystonia (HP:0002451)1.69298071
160Abnormality of the pons (HP:0007361)1.67639444
161Focal motor seizures (HP:0011153)1.67594130
162Nausea (HP:0002018)1.65093958
163Short tibia (HP:0005736)1.64298732
164Optic nerve hypoplasia (HP:0000609)1.63717303
165Hyperglycinemia (HP:0002154)1.62265259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.47172447
2EIF2AK13.74999431
3WEE13.38301262
4STK163.33182990
5TESK22.63424755
6WNK32.59177647
7MAP4K22.55937401
8BRSK22.53178046
9PIM22.45073050
10NME22.42204373
11SRPK12.37903714
12TRIM282.34271236
13EIF2AK32.33203877
14MAP3K122.21644911
15CDC72.07404034
16PINK12.06858153
17VRK11.94459337
18NUAK11.89957274
19ACVR1B1.84975935
20TESK11.83535099
21MAP2K71.82885053
22TSSK61.82697973
23CCNB11.82419600
24FRK1.80154646
25CASK1.73122301
26MAP3K41.71014136
27PLK41.70381620
28VRK21.65957029
29BRSK11.57172530
30GRK11.49922896
31LIMK11.43992016
32PLK11.42850790
33ARAF1.39707816
34PASK1.38916266
35TLK11.37914674
36SCYL21.37385355
37CSNK1G21.36687429
38PLK31.36113482
39INSRR1.33814593
40EPHA21.33641976
41MARK11.33137762
42DYRK31.31500565
43MAP4K11.30108681
44MKNK11.28983049
45RPS6KB21.26699861
46NEK21.25235051
47PBK1.23111576
48MST41.22341411
49CAMKK21.17494604
50NME11.16563228
51IRAK41.15777079
52ATR1.15429109
53CSNK1G11.15254102
54ZAK1.13588246
55SIK31.13437076
56AURKB1.12425569
57PRKCG1.06750921
58GRK71.05669065
59OXSR11.04511646
60AURKA1.04448032
61NEK11.03596008
62MAPK131.03446184
63CSNK1A1L1.00847501
64DYRK21.00839906
65BRAF1.00386746
66PIM10.99625063
67PRKCE0.99046686
68TAOK30.98848795
69PAK40.98418311
70TNIK0.97517339
71CDK190.97468289
72CDK70.96421735
73CHEK20.96052159
74TEC0.95823383
75MAP3K110.94833063
76DAPK20.93993489
77KIT0.92945060
78TAF10.92289098
79TTK0.90237082
80DAPK10.90179790
81RPS6KA40.90032442
82PLK20.90012128
83BLK0.88878853
84MAPKAPK30.88386548
85BCKDK0.82046599
86EIF2AK20.81704019
87CDK80.80054143
88MAP3K50.79914294
89MINK10.76877127
90ZAP700.75703072
91TGFBR10.74402336
92LRRK20.73589132
93MAP3K80.73092368
94MAP3K140.72882075
95IKBKB0.71780302
96KDR0.69463869
97BTK0.69065036
98STK40.68132246
99CSF1R0.68021739
100ERBB30.66696108
101MKNK20.66094189
102CSNK2A10.66054257
103BCR0.66041301
104TIE10.65604320
105CHEK10.65273413
106FLT30.63548567
107TXK0.63168385
108ADRBK10.62765377
109MARK30.62294833
110PAK30.61743368
111PDK20.61473280
112PRKCI0.61334217
113CSNK2A20.60494410
114ABL20.60491193
115SYK0.60044393
116MATK0.59881670
117CAMK2A0.59444425
118PAK10.59053522
119STK100.56281611
120CDK40.55850685
121ILK0.51435469
122MAP3K90.51379815
123RIPK40.50738863
124YES10.50567035
125LYN0.43843603
126CSNK1A10.42087406
127STK38L0.41728761
128CSNK1G30.40868130
129TAOK20.40827147
130BMPR1B0.40223439
131PRPF4B0.38705172
132ADRBK20.38375324
133EGFR0.37800279
134DAPK30.37256373
135RPS6KA50.37045332
136WNK40.36562679
137PKN10.36404147
138PRKACA0.35622271
139MAP2K60.35018576
140CDK20.34054604
141GRK60.33418043
142BMPR20.33075625
143ABL10.31607032
144PRKCQ0.31335376
145FGR0.29897603
146NTRK20.29754028
147GRK50.28253643
148PNCK0.28078042

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.82503420
2DNA replication_Homo sapiens_hsa030304.45396196
3Ribosome_Homo sapiens_hsa030104.28818306
4Mismatch repair_Homo sapiens_hsa034303.80374698
5RNA polymerase_Homo sapiens_hsa030203.57680086
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.23829561
7Spliceosome_Homo sapiens_hsa030402.89577783
8Base excision repair_Homo sapiens_hsa034102.85802344
9Nucleotide excision repair_Homo sapiens_hsa034202.71665858
10Homologous recombination_Homo sapiens_hsa034402.61664426
11Pyrimidine metabolism_Homo sapiens_hsa002402.58385774
12RNA transport_Homo sapiens_hsa030132.47888793
13Protein export_Homo sapiens_hsa030602.01528174
14Cell cycle_Homo sapiens_hsa041101.96451633
15Non-homologous end-joining_Homo sapiens_hsa034501.96116618
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90358419
17Basal transcription factors_Homo sapiens_hsa030221.86032499
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80674699
19Oxidative phosphorylation_Homo sapiens_hsa001901.76389355
20Fanconi anemia pathway_Homo sapiens_hsa034601.74096267
21Parkinsons disease_Homo sapiens_hsa050121.70328217
22Cardiac muscle contraction_Homo sapiens_hsa042601.70086102
23RNA degradation_Homo sapiens_hsa030181.69161799
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63593738
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60675407
26Phototransduction_Homo sapiens_hsa047441.59037377
27One carbon pool by folate_Homo sapiens_hsa006701.57082588
28Selenocompound metabolism_Homo sapiens_hsa004501.53503252
29Nicotine addiction_Homo sapiens_hsa050331.48951921
30p53 signaling pathway_Homo sapiens_hsa041151.48587774
31Huntingtons disease_Homo sapiens_hsa050161.45128823
32Purine metabolism_Homo sapiens_hsa002301.38313120
33Epstein-Barr virus infection_Homo sapiens_hsa051691.30286659
34Sulfur metabolism_Homo sapiens_hsa009201.27380554
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18901861
36mRNA surveillance pathway_Homo sapiens_hsa030151.10567880
37Primary immunodeficiency_Homo sapiens_hsa053401.08930545
38Steroid biosynthesis_Homo sapiens_hsa001001.06887861
39Synaptic vesicle cycle_Homo sapiens_hsa047211.05836753
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02662434
41Antigen processing and presentation_Homo sapiens_hsa046121.01905949
42Butanoate metabolism_Homo sapiens_hsa006500.99403411
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98111337
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97996247
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91459836
46Linoleic acid metabolism_Homo sapiens_hsa005910.91238029
47Ether lipid metabolism_Homo sapiens_hsa005650.88857552
48Alzheimers disease_Homo sapiens_hsa050100.88636509
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86052748
50GABAergic synapse_Homo sapiens_hsa047270.85894170
51Nitrogen metabolism_Homo sapiens_hsa009100.85186185
52Allograft rejection_Homo sapiens_hsa053300.84882115
53Herpes simplex infection_Homo sapiens_hsa051680.84789929
54Propanoate metabolism_Homo sapiens_hsa006400.84376340
55Pentose phosphate pathway_Homo sapiens_hsa000300.83812804
56Shigellosis_Homo sapiens_hsa051310.82820144
57Morphine addiction_Homo sapiens_hsa050320.81339370
58Fatty acid elongation_Homo sapiens_hsa000620.80897182
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80121986
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.80068046
61Folate biosynthesis_Homo sapiens_hsa007900.80058049
62Legionellosis_Homo sapiens_hsa051340.79194076
63Peroxisome_Homo sapiens_hsa041460.77588839
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76893213
65Lysosome_Homo sapiens_hsa041420.74308780
66Graft-versus-host disease_Homo sapiens_hsa053320.72677712
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71982013
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71926837
69Olfactory transduction_Homo sapiens_hsa047400.71737089
70Tryptophan metabolism_Homo sapiens_hsa003800.66981570
71Systemic lupus erythematosus_Homo sapiens_hsa053220.64587700
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.64246437
73Viral carcinogenesis_Homo sapiens_hsa052030.64070600
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63285537
75Taste transduction_Homo sapiens_hsa047420.62851602
76Glutathione metabolism_Homo sapiens_hsa004800.62782462
77Regulation of autophagy_Homo sapiens_hsa041400.62593806
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61636021
79Oocyte meiosis_Homo sapiens_hsa041140.60830138
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60775472
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.59309051
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.57586638
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56886456
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54703118
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.54545022
86Apoptosis_Homo sapiens_hsa042100.52485707
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.52212438
88Measles_Homo sapiens_hsa051620.52196306
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50741122
90N-Glycan biosynthesis_Homo sapiens_hsa005100.48918017
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47679076
92Staphylococcus aureus infection_Homo sapiens_hsa051500.45415844
93Vibrio cholerae infection_Homo sapiens_hsa051100.44935255
94Circadian rhythm_Homo sapiens_hsa047100.44405635
95Asthma_Homo sapiens_hsa053100.44388357
96Hematopoietic cell lineage_Homo sapiens_hsa046400.43662189
97Type I diabetes mellitus_Homo sapiens_hsa049400.42971384
98Autoimmune thyroid disease_Homo sapiens_hsa053200.42091728
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.41824279
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41719688
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40925033
102Phagosome_Homo sapiens_hsa041450.40696675
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40406203
104HTLV-I infection_Homo sapiens_hsa051660.39810125
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38694186
106Caffeine metabolism_Homo sapiens_hsa002320.38288308
107Serotonergic synapse_Homo sapiens_hsa047260.38025245
108Leishmaniasis_Homo sapiens_hsa051400.38021865
109Mineral absorption_Homo sapiens_hsa049780.37742700
110Chemical carcinogenesis_Homo sapiens_hsa052040.36232388
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36017818
112beta-Alanine metabolism_Homo sapiens_hsa004100.35359318
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35135418
114Metabolic pathways_Homo sapiens_hsa011000.34488568
115Pyruvate metabolism_Homo sapiens_hsa006200.34232650
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33311641
117Arachidonic acid metabolism_Homo sapiens_hsa005900.33000042
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32432212
119Biosynthesis of amino acids_Homo sapiens_hsa012300.32364727
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30032360
121Influenza A_Homo sapiens_hsa051640.29687828
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28602844
123Viral myocarditis_Homo sapiens_hsa054160.28484985
124Collecting duct acid secretion_Homo sapiens_hsa049660.27967589
125Hepatitis B_Homo sapiens_hsa051610.27089132
126Vitamin B6 metabolism_Homo sapiens_hsa007500.27049927
127Fructose and mannose metabolism_Homo sapiens_hsa000510.25393788
128Pertussis_Homo sapiens_hsa051330.22846555
129Rheumatoid arthritis_Homo sapiens_hsa053230.22052965
130Thyroid cancer_Homo sapiens_hsa052160.21869898
131Galactose metabolism_Homo sapiens_hsa000520.21769263
132Other glycan degradation_Homo sapiens_hsa005110.21193427
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19874411
134Alcoholism_Homo sapiens_hsa050340.19288059
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18922739
136B cell receptor signaling pathway_Homo sapiens_hsa046620.18693256
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18202430
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16075369
139Carbon metabolism_Homo sapiens_hsa012000.15649805
140Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15109039
141Salmonella infection_Homo sapiens_hsa051320.14919533
142Tuberculosis_Homo sapiens_hsa051520.14570671
143Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14150722
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13514734

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