BLOC1S3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a component of the BLOC1 multi-subunit protein complex. This complex is necessary for the biogenesis of specialized organelles of the endosomal-lysosomal system, including platelet dense granules and melanosomes. Mutations in this gene cause Hermansky-Pudlak syndrome 8, a disease characterized by lysosomal storage defects, bleeding due to platelet storage pool deficiency, and oculocutaneous albinism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.33730873
2protein K6-linked ubiquitination (GO:0085020)4.39158283
3ribosomal small subunit assembly (GO:0000028)4.25007862
4water-soluble vitamin biosynthetic process (GO:0042364)4.08345884
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.06008420
6mitochondrial respiratory chain complex assembly (GO:0033108)3.89192059
7regulation of nuclear cell cycle DNA replication (GO:0033262)3.86419102
8intra-S DNA damage checkpoint (GO:0031573)3.80257922
9regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.80002214
10piRNA metabolic process (GO:0034587)3.78790584
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.73672323
12mitochondrial respiratory chain complex I assembly (GO:0032981)3.73672323
13NADH dehydrogenase complex assembly (GO:0010257)3.73672323
14tRNA methylation (GO:0030488)3.71871359
15telomere maintenance via semi-conservative replication (GO:0032201)3.55380769
16response to peptidoglycan (GO:0032494)3.54375154
17* platelet dense granule organization (GO:0060155)3.44233860
18ketone body metabolic process (GO:1902224)3.40896969
19superoxide anion generation (GO:0042554)3.40129471
20mannosylation (GO:0097502)3.33230708
21keratinocyte development (GO:0003334)3.32427560
22response to pheromone (GO:0019236)3.31581304
23cellular ketone body metabolic process (GO:0046950)3.30907622
24proteasome assembly (GO:0043248)3.27063049
25regulation of glucokinase activity (GO:0033131)3.26971519
26regulation of hexokinase activity (GO:1903299)3.26971519
27adaptation of signaling pathway (GO:0023058)3.22670173
28negative regulation of DNA-dependent DNA replication (GO:2000104)3.17534924
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.17345076
30termination of RNA polymerase III transcription (GO:0006386)3.17345076
31DNA methylation involved in gamete generation (GO:0043046)3.16650518
32negative regulation of mast cell activation (GO:0033004)3.13500088
33cullin deneddylation (GO:0010388)3.12773965
34negative regulation of transcription by competitive promoter binding (GO:0010944)3.12542887
35protein deneddylation (GO:0000338)3.12122620
36L-fucose catabolic process (GO:0042355)3.11427103
37fucose catabolic process (GO:0019317)3.11427103
38L-fucose metabolic process (GO:0042354)3.11427103
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.07738958
40telomere maintenance via recombination (GO:0000722)3.07532395
41detection of light stimulus involved in sensory perception (GO:0050962)3.04523965
42detection of light stimulus involved in visual perception (GO:0050908)3.04523965
43purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.01418864
443-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.01418864
45C-terminal protein lipidation (GO:0006501)3.00098582
46polyketide metabolic process (GO:0030638)2.97213220
47doxorubicin metabolic process (GO:0044598)2.97213220
48daunorubicin metabolic process (GO:0044597)2.97213220
49peptidyl-histidine modification (GO:0018202)2.96880270
50tryptophan catabolic process (GO:0006569)2.93643391
51indole-containing compound catabolic process (GO:0042436)2.93643391
52indolalkylamine catabolic process (GO:0046218)2.93643391
53indolalkylamine metabolic process (GO:0006586)2.93622611
54xenobiotic catabolic process (GO:0042178)2.92716701
55inositol phosphate catabolic process (GO:0071545)2.92194962
56tRNA modification (GO:0006400)2.91147017
57positive regulation of prostaglandin secretion (GO:0032308)2.86275432
58DNA strand elongation involved in DNA replication (GO:0006271)2.84398214
59DNA strand elongation (GO:0022616)2.82805644
60axoneme assembly (GO:0035082)2.82717128
61replication fork processing (GO:0031297)2.82341920
62tryptophan metabolic process (GO:0006568)2.82156581
63cytochrome complex assembly (GO:0017004)2.81904049
64lactate metabolic process (GO:0006089)2.81214720
65mitotic recombination (GO:0006312)2.80808778
66regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.79314372
67nucleotide transmembrane transport (GO:1901679)2.79164782
68interferon-gamma production (GO:0032609)2.77955056
69viral transcription (GO:0019083)2.76774750
70RNA methylation (GO:0001510)2.76497937
71rRNA modification (GO:0000154)2.75524906
72iron-sulfur cluster assembly (GO:0016226)2.74859382
73metallo-sulfur cluster assembly (GO:0031163)2.74859382
74protein polyglutamylation (GO:0018095)2.73981864
75telomere maintenance via telomere lengthening (GO:0010833)2.73088741
76behavioral response to nicotine (GO:0035095)2.72970157
77GPI anchor metabolic process (GO:0006505)2.72941158
78ribosomal large subunit biogenesis (GO:0042273)2.72201075
79CENP-A containing nucleosome assembly (GO:0034080)2.71958836
80regulation of B cell apoptotic process (GO:0002902)2.71787651
81pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.70325152
82C-terminal protein amino acid modification (GO:0018410)2.69839336
83respiratory chain complex IV assembly (GO:0008535)2.69717947
84protein-cofactor linkage (GO:0018065)2.68641698
85SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.67935559
86dopamine transport (GO:0015872)2.66686029
87translational termination (GO:0006415)2.66636342
88lymphoid progenitor cell differentiation (GO:0002320)2.66323427
89energy homeostasis (GO:0097009)2.65137731
90multicellular organism reproduction (GO:0032504)2.64571456
91amino sugar catabolic process (GO:0046348)2.62033677
92kinetochore assembly (GO:0051382)2.61066343
93inositol phosphate dephosphorylation (GO:0046855)2.59708762
94phosphorylated carbohydrate dephosphorylation (GO:0046838)2.59708762
95cotranslational protein targeting to membrane (GO:0006613)2.59382829
96polyol catabolic process (GO:0046174)2.58963267
97regulation of meiosis I (GO:0060631)2.58378114
98negative regulation of acute inflammatory response (GO:0002674)2.58242772
99maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.57840284
100dendritic cell chemotaxis (GO:0002407)2.57624402
101protein targeting to ER (GO:0045047)2.56927732
102neutrophil mediated immunity (GO:0002446)2.56904754
103amine catabolic process (GO:0009310)2.56508273
104cellular biogenic amine catabolic process (GO:0042402)2.56508273
105maturation of SSU-rRNA (GO:0030490)2.56469620
106regulation of mitochondrial translation (GO:0070129)2.55696625
107mitochondrial RNA metabolic process (GO:0000959)2.55532010
108tRNA processing (GO:0008033)2.55287866
109response to interferon-beta (GO:0035456)2.54781011
110DNA replication checkpoint (GO:0000076)2.54034970
111chromatin remodeling at centromere (GO:0031055)2.52820945
112dendritic cell migration (GO:0036336)2.52386215
113regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.51769042
114pseudouridine synthesis (GO:0001522)2.51698038
115protein localization to cilium (GO:0061512)2.51625052
116G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.50360316
117detection of other organism (GO:0098543)2.49869147
118regulation of antigen processing and presentation (GO:0002577)2.49656912
119DNA synthesis involved in DNA repair (GO:0000731)2.49563859
120lipoxygenase pathway (GO:0019372)2.49489077
121mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.49234326
122ubiquinone biosynthetic process (GO:0006744)2.49148092
123negative regulation of protein autophosphorylation (GO:0031953)2.49062721
124RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.48758717
125tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.48758717
126regulation of neurotransmitter uptake (GO:0051580)2.47898124
127negative regulation of phagocytosis (GO:0050765)2.44992380
128negative regulation of execution phase of apoptosis (GO:1900118)2.44957027
129defense response to protozoan (GO:0042832)2.44745203
130ribosomal small subunit biogenesis (GO:0042274)2.44625758
131negative regulation of telomere maintenance (GO:0032205)2.44523120
132S-adenosylmethionine metabolic process (GO:0046500)2.44504861
133GPI anchor biosynthetic process (GO:0006506)2.43787131
134nucleotide-excision repair, DNA gap filling (GO:0006297)2.43423768
135regulation of double-strand break repair via homologous recombination (GO:0010569)2.43127217
136protein localization to endoplasmic reticulum (GO:0070972)2.42448011
137protein K11-linked deubiquitination (GO:0035871)2.41316995
138DNA replication initiation (GO:0006270)2.41157147
139DNA catabolic process, exonucleolytic (GO:0000738)2.41067299
140base-excision repair, AP site formation (GO:0006285)2.40957063
141establishment of protein localization to endoplasmic reticulum (GO:0072599)2.40564772
142positive regulation of protein autophosphorylation (GO:0031954)2.39875945
143rRNA methylation (GO:0031167)2.39736558
144regulation of memory T cell differentiation (GO:0043380)2.39702396
145synapsis (GO:0007129)2.38611385
146phosphatidylinositol acyl-chain remodeling (GO:0036149)2.38496046
147pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.37900852
148immunoglobulin mediated immune response (GO:0016064)2.36165888
149regulation of mast cell activation (GO:0033003)2.36004862
150I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.35695569
151deoxyribonucleotide catabolic process (GO:0009264)2.35378634
152signal peptide processing (GO:0006465)2.35229816
153DNA-dependent DNA replication (GO:0006261)2.34076205
154nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.33432407
155sulfation (GO:0051923)2.32681624
156preassembly of GPI anchor in ER membrane (GO:0016254)2.32461921
157centriole assembly (GO:0098534)2.32440251
158purine deoxyribonucleotide catabolic process (GO:0009155)2.32423421
159negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.32286056
160positive regulation of meiosis (GO:0045836)2.31754769
161natural killer cell activation involved in immune response (GO:0002323)2.31726391
162mast cell activation (GO:0045576)2.31230087
163RNA modification (GO:0009451)2.31166165
164cornea development in camera-type eye (GO:0061303)2.30923961
165nitric oxide biosynthetic process (GO:0006809)2.30469099
166detection of bacterium (GO:0016045)2.30329411
167parental behavior (GO:0060746)2.30074568
168branched-chain amino acid catabolic process (GO:0009083)2.29488240
169deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.29486953
170protein complex biogenesis (GO:0070271)2.29360489
171positive regulation of antigen processing and presentation (GO:0002579)2.28326178
172glycosphingolipid catabolic process (GO:0046479)2.27802882
173ATP hydrolysis coupled proton transport (GO:0015991)2.27461047
174energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.27461047
175regulation of type B pancreatic cell apoptotic process (GO:2000674)2.27231347
176pyrimidine nucleotide catabolic process (GO:0006244)2.27110460
177establishment of protein localization to mitochondrial membrane (GO:0090151)2.27052708
178dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.26571945
179positive regulation of B cell differentiation (GO:0045579)2.25691324
180startle response (GO:0001964)2.25581898
181superoxide metabolic process (GO:0006801)2.25519962
182detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.24718798
183exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.24612801
184DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.23201844
185kynurenine metabolic process (GO:0070189)2.21977201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.90409266
2ZNF274_21170338_ChIP-Seq_K562_Hela3.75072403
3* ELF1_17652178_ChIP-ChIP_JURKAT_Human3.67530280
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26780041
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.05128500
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.04416096
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02960540
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.84779022
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.84671599
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.83805417
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81241837
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.75188062
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.71515546
14FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.67050676
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.65758045
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.59652686
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51795378
18VDR_22108803_ChIP-Seq_LS180_Human2.49219241
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.47580109
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42175325
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.40852356
22SCL_19346495_ChIP-Seq_HPC-7_Human2.32775571
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31137524
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27847105
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.22923694
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17558676
27* FOXP3_21729870_ChIP-Seq_TREG_Human2.16047684
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15585779
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15321848
30ETS1_20019798_ChIP-Seq_JURKAT_Human2.13947863
31VDR_23849224_ChIP-Seq_CD4+_Human2.12078529
32SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.12025051
33E2F4_17652178_ChIP-ChIP_JURKAT_Human2.06349686
34* SRF_21415370_ChIP-Seq_HL-1_Mouse2.05198517
35SPI1_23547873_ChIP-Seq_NB4_Human2.03546176
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.03024032
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02927285
38GBX2_23144817_ChIP-Seq_PC3_Human2.02630305
39ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01328918
40MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01165301
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96152253
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95771231
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.92956760
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.90748202
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89846212
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.88038967
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86525217
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.79981418
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78296568
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74886697
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74513083
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.71756633
53DCP1A_22483619_ChIP-Seq_HELA_Human1.69518538
54ER_23166858_ChIP-Seq_MCF-7_Human1.65515964
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64953121
56GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.62465551
57P300_19829295_ChIP-Seq_ESCs_Human1.62052735
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59855419
59BCAT_22108803_ChIP-Seq_LS180_Human1.58946214
60EWS_26573619_Chip-Seq_HEK293_Human1.57366256
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55194498
62ELK1_19687146_ChIP-ChIP_HELA_Human1.54993586
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.53159606
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.53159606
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53127310
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50751051
67TTF2_22483619_ChIP-Seq_HELA_Human1.50233570
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.48516820
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47441545
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.46783253
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46766479
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46248408
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46247891
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46152917
75TP53_22573176_ChIP-Seq_HFKS_Human1.45147049
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43832953
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42935809
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41200030
79GATA3_26560356_Chip-Seq_TH2_Human1.39704330
80NANOG_19829295_ChIP-Seq_ESCs_Human1.39349674
81SOX2_19829295_ChIP-Seq_ESCs_Human1.39349674
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36785782
83FUS_26573619_Chip-Seq_HEK293_Human1.36576142
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36500039
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35899347
86AR_20517297_ChIP-Seq_VCAP_Human1.34736297
87IGF1R_20145208_ChIP-Seq_DFB_Human1.34640683
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34338249
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33277034
90EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32977889
91IRF8_27001747_Chip-Seq_BMDM_Mouse1.32207453
92* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31755051
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29895510
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.29181756
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.28885458
96CBP_20019798_ChIP-Seq_JUKART_Human1.28657364
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28657364
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28290860
99NCOR_22424771_ChIP-Seq_293T_Human1.27416378
100MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27035610
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26458956
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.26196341
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25428886
104CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24858120
105* MYC_18940864_ChIP-ChIP_HL60_Human1.23306059
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.19207045
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18013302
108MYB_26560356_Chip-Seq_TH2_Human1.17971322
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17634131
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16762937
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16350670
112HOXB7_26014856_ChIP-Seq_BT474_Human1.15631437
113AR_25329375_ChIP-Seq_VCAP_Human1.15198023
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13568436
115GABP_19822575_ChIP-Seq_HepG2_Human1.12891246
116XRN2_22483619_ChIP-Seq_HELA_Human1.12845404
117CRX_20693478_ChIP-Seq_RETINA_Mouse1.12083827
118AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11505222
119THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11202815
120TCF4_22108803_ChIP-Seq_LS180_Human1.10913527
121RUNX1_22412390_ChIP-Seq_EML_Mouse1.10732102
122FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10615032
123IRF1_19129219_ChIP-ChIP_H3396_Human1.08611225
124CDX2_22108803_ChIP-Seq_LS180_Human1.08500693
125SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08493637
126CIITA_25753668_ChIP-Seq_RAJI_Human1.08203045
127NANOG_20526341_ChIP-Seq_ESCs_Human1.07890760
128MYB_26560356_Chip-Seq_TH1_Human1.07408458
129SMAD4_21799915_ChIP-Seq_A2780_Human1.06399173
130MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05894907
131PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05812348
132CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04300037
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04264314
134E2F1_21310950_ChIP-Seq_MCF-7_Human1.03336435
135TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03120781
136TCF4_23295773_ChIP-Seq_U87_Human1.01487798
137FOXH1_21741376_ChIP-Seq_EPCs_Human1.01257719
138STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01007433
139MYC_19829295_ChIP-Seq_ESCs_Human1.00525128
140PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00439813
141PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00033900
142ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99896993
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.98987078
144SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98252211
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98176753
146STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97950710
147CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97920093
148NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97905744
149GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97823496
150STAT3_23295773_ChIP-Seq_U87_Human0.97786040
151NELFA_20434984_ChIP-Seq_ESCs_Mouse0.96999770
152KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96770899
153ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95685589
154YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95053219
155CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94833093
156STAT3_18555785_Chip-Seq_ESCs_Mouse0.93811593
157SMAD4_21741376_ChIP-Seq_EPCs_Human0.93768896
158SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93659076
159NANOG_18555785_Chip-Seq_ESCs_Mouse0.93467863
160GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93337137
161VDR_24763502_ChIP-Seq_THP-1_Human0.88424325
162NMYC_18555785_Chip-Seq_ESCs_Mouse0.87769318
163CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85433640
164BRD4_27068464_Chip-Seq_AML-cells_Mouse0.85239819
165SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84988307
166SUZ12_18555785_Chip-Seq_ESCs_Mouse0.83322428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.32270598
2MP0006292_abnormal_olfactory_placode3.91102201
3MP0001835_abnormal_antigen_presentation3.11207120
4MP0001188_hyperpigmentation3.09388209
5MP0002837_dystrophic_cardiac_calcinosis2.91767889
6MP0002396_abnormal_hematopoietic_system2.84526730
7MP0002102_abnormal_ear_morphology2.71863864
8MP0008058_abnormal_DNA_repair2.65499936
9MP0009379_abnormal_foot_pigmentation2.59982583
10MP0009785_altered_susceptibility_to2.54148315
11* MP0005174_abnormal_tail_pigmentation2.48867999
12MP0008877_abnormal_DNA_methylation2.48190626
13MP0003646_muscle_fatigue2.31059154
14MP0005671_abnormal_response_to2.28163921
15MP0002163_abnormal_gland_morphology2.27833461
16MP0002132_abnormal_respiratory_system2.23716775
17MP0002148_abnormal_hypersensitivity_rea2.19065014
18MP0002138_abnormal_hepatobiliary_system2.18678987
19MP0003693_abnormal_embryo_hatching2.16145607
20* MP0000015_abnormal_ear_pigmentation2.10673365
21MP0005551_abnormal_eye_electrophysiolog2.08268016
22MP0005084_abnormal_gallbladder_morpholo2.02938607
23MP0008057_abnormal_DNA_replication2.00612856
24MP0000490_abnormal_crypts_of2.00006183
25MP0000516_abnormal_urinary_system1.99157796
26MP0005367_renal/urinary_system_phenotyp1.99157796
27MP0005025_abnormal_response_to1.98054490
28MP0002638_abnormal_pupillary_reflex1.97114180
29MP0005409_darkened_coat_color1.95707164
30MP0003436_decreased_susceptibility_to1.89209634
31MP0002277_abnormal_respiratory_mucosa1.88852205
32MP0002419_abnormal_innate_immunity1.87914824
33MP0003136_yellow_coat_color1.83682873
34MP0003724_increased_susceptibility_to1.83123594
35MP0005000_abnormal_immune_tolerance1.81428193
36MP0000566_synostosis1.80013548
37MP0005646_abnormal_pituitary_gland1.79824908
38MP0003011_delayed_dark_adaptation1.78804705
39MP0008872_abnormal_physiological_respon1.78213344
40MP0010094_abnormal_chromosome_stability1.77238920
41MP0003806_abnormal_nucleotide_metabolis1.76139458
42MP0001986_abnormal_taste_sensitivity1.75932627
43* MP0005075_abnormal_melanosome_morpholog1.73183582
44MP0002452_abnormal_antigen_presenting1.72605483
45MP0008007_abnormal_cellular_replicative1.71907990
46MP0001790_abnormal_immune_system1.70084764
47MP0005387_immune_system_phenotype1.70084764
48MP0002723_abnormal_immune_serum1.68906352
49MP0002139_abnormal_hepatobiliary_system1.68279200
50MP0001800_abnormal_humoral_immune1.67763402
51* MP0002420_abnormal_adaptive_immunity1.66656708
52* MP0001819_abnormal_immune_cell1.65877128
53MP0003763_abnormal_thymus_physiology1.64937903
54MP0001968_abnormal_touch/_nociception1.62790537
55MP0002928_abnormal_bile_duct1.59227477
56MP0003786_premature_aging1.59027461
57MP0006036_abnormal_mitochondrial_physio1.57834663
58MP0005408_hypopigmentation1.57267948
59MP0000685_abnormal_immune_system1.56695137
60MP0002398_abnormal_bone_marrow1.54943447
61MP0003111_abnormal_nucleus_morphology1.54895277
62* MP0002095_abnormal_skin_pigmentation1.54594050
63MP0002254_reproductive_system_inflammat1.50727813
64MP0000372_irregular_coat_pigmentation1.50723934
65MP0000427_abnormal_hair_cycle1.49453046
66MP0008995_early_reproductive_senescence1.44720772
67MP0009333_abnormal_splenocyte_physiolog1.43561578
68MP0005253_abnormal_eye_physiology1.43170722
69MP0000716_abnormal_immune_system1.42660467
70MP0008789_abnormal_olfactory_epithelium1.41059447
71MP0004142_abnormal_muscle_tone1.40771000
72MP0003787_abnormal_imprinting1.40395734
73MP0009046_muscle_twitch1.40143275
74MP0005464_abnormal_platelet_physiology1.39538694
75MP0002405_respiratory_system_inflammati1.38385032
76MP0006072_abnormal_retinal_apoptosis1.36201757
77MP0008260_abnormal_autophagy1.34120816
78MP0008875_abnormal_xenobiotic_pharmacok1.33546154
79MP0002693_abnormal_pancreas_physiology1.33207529
80MP0001853_heart_inflammation1.33123065
81MP0005410_abnormal_fertilization1.32365367
82MP0010155_abnormal_intestine_physiology1.32357353
83MP0004808_abnormal_hematopoietic_stem1.32030632
84MP0003941_abnormal_skin_development1.31647264
85MP0002736_abnormal_nociception_after1.29884696
86MP0000678_abnormal_parathyroid_gland1.29391677
87MP0000681_abnormal_thyroid_gland1.29133223
88MP0002090_abnormal_vision1.28830874
89MP0000689_abnormal_spleen_morphology1.28745387
90MP0004147_increased_porphyrin_level1.27904340
91MP0002722_abnormal_immune_system1.27719476
92MP0001545_abnormal_hematopoietic_system1.24650563
93MP0005397_hematopoietic_system_phenotyp1.24650563
94MP0001485_abnormal_pinna_reflex1.24209351
95MP0002429_abnormal_blood_cell1.23502604
96MP0003950_abnormal_plasma_membrane1.22980303
97MP0009840_abnormal_foam_cell1.21496065
98MP0003077_abnormal_cell_cycle1.21442040
99* MP0001324_abnormal_eye_pigmentation1.21090415
100MP0006035_abnormal_mitochondrial_morpho1.20066748
101MP0001905_abnormal_dopamine_level1.17910510
102MP0010386_abnormal_urinary_bladder1.17738947
103MP0006082_CNS_inflammation1.16569105
104MP0003186_abnormal_redox_activity1.15542881
105MP0005389_reproductive_system_phenotype1.14502273
106MP0000858_altered_metastatic_potential1.14338551
107MP0005310_abnormal_salivary_gland1.12590921
108MP0005332_abnormal_amino_acid1.11144290
109MP0000703_abnormal_thymus_morphology1.07618961
110MP0005499_abnormal_olfactory_system1.07314628
111MP0005394_taste/olfaction_phenotype1.07314628
112MP0003252_abnormal_bile_duct1.06332620
113MP0004782_abnormal_surfactant_physiolog1.04776690
114* MP0009745_abnormal_behavioral_response1.04555728
115MP0000465_gastrointestinal_hemorrhage1.04291370
116MP0001944_abnormal_pancreas_morphology1.03768875
117MP0001845_abnormal_inflammatory_respons1.03051047
118MP0000569_abnormal_digit_pigmentation1.02172787
119MP0000613_abnormal_salivary_gland1.01606840
120* MP0001186_pigmentation_phenotype1.01496790
121MP0002160_abnormal_reproductive_system1.00557306
122MP0002006_tumorigenesis0.98160529
123MP0004885_abnormal_endolymph0.97926506
124MP0002909_abnormal_adrenal_gland0.97124382
125MP0009764_decreased_sensitivity_to0.97014596
126MP0005379_endocrine/exocrine_gland_phen0.96892099
127MP0002272_abnormal_nervous_system0.95565142
128MP0003866_abnormal_defecation0.95290412
129MP0009780_abnormal_chondrocyte_physiolo0.94284201
130MP0000538_abnormal_urinary_bladder0.92225725
131MP0002229_neurodegeneration0.92200276
132MP0001756_abnormal_urination0.91700865
133MP0005171_absent_coat_pigmentation0.90644688
134MP0001501_abnormal_sleep_pattern0.89731207
135* MP0000371_diluted_coat_color0.87252444
136MP0008469_abnormal_protein_level0.85362700
137MP0000313_abnormal_cell_death0.85345552
138MP0010329_abnormal_lipoprotein_level0.85070914
139* MP0004381_abnormal_hair_follicle0.83871996
140MP0005377_hearing/vestibular/ear_phenot0.83725272
141MP0003878_abnormal_ear_physiology0.83725272
142MP0000230_abnormal_systemic_arterial0.82346411
143MP0001929_abnormal_gametogenesis0.82047700
144MP0000631_abnormal_neuroendocrine_gland0.81914989
145* MP0002075_abnormal_coat/hair_pigmentati0.79993699
146MP0000049_abnormal_middle_ear0.79321263
147MP0005636_abnormal_mineral_homeostasis0.79115051
148MP0002166_altered_tumor_susceptibility0.79007295
149MP0002751_abnormal_autonomic_nervous0.78863399
150MP0002019_abnormal_tumor_incidence0.78642506
151MP0001919_abnormal_reproductive_system0.78451985
152MP0003938_abnormal_ear_development0.76627856
153MP0003656_abnormal_erythrocyte_physiolo0.74717836
154MP0005395_other_phenotype0.73981552
155MP0002938_white_spotting0.73558283
156MP0005645_abnormal_hypothalamus_physiol0.73254205
157MP0003718_maternal_effect0.70480054
158MP0000026_abnormal_inner_ear0.67411425
159MP0001873_stomach_inflammation0.64704335
160MP0001764_abnormal_homeostasis0.64696163
161MP0002876_abnormal_thyroid_physiology0.64677713

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.46022883
2Type I transferrin isoform profile (HP:0003642)4.05320257
3Reticulocytopenia (HP:0001896)3.85119480
4Chromsome breakage (HP:0040012)3.83634645
5Reduced antithrombin III activity (HP:0001976)3.80930115
6Congenital stationary night blindness (HP:0007642)3.67747613
7Recurrent abscess formation (HP:0002722)3.38906334
8Acute necrotizing encephalopathy (HP:0006965)3.34293397
9Progressive macrocephaly (HP:0004481)3.21266021
10Abnormality of the renal collecting system (HP:0004742)3.19590681
11Myositis (HP:0100614)3.16050135
12Molar tooth sign on MRI (HP:0002419)3.14131577
13Abnormality of midbrain morphology (HP:0002418)3.14131577
14Retrobulbar optic neuritis (HP:0100654)3.05528124
15Optic neuritis (HP:0100653)3.05528124
16Methylmalonic acidemia (HP:0002912)3.01086681
17Duplicated collecting system (HP:0000081)3.01016994
18Chronic otitis media (HP:0000389)3.00284813
19Mitochondrial inheritance (HP:0001427)2.99917305
20Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.96950955
21Abnormal protein N-linked glycosylation (HP:0012347)2.96950955
22Abnormal protein glycosylation (HP:0012346)2.96950955
23Abnormal glycosylation (HP:0012345)2.96950955
24Abnormal mitochondria in muscle tissue (HP:0008316)2.95128877
25Increased CSF lactate (HP:0002490)2.95119109
26Ketoacidosis (HP:0001993)2.90728953
27Aplastic anemia (HP:0001915)2.89432513
28Abnormality of DNA repair (HP:0003254)2.87867996
29Acute encephalopathy (HP:0006846)2.86304245
30Stomatitis (HP:0010280)2.84400983
31Chronic obstructive pulmonary disease (HP:0006510)2.84106320
32Obstructive lung disease (HP:0006536)2.84106320
33Abnormality of the preputium (HP:0100587)2.80632913
34Methylmalonic aciduria (HP:0012120)2.79816700
35Recurrent bacterial skin infections (HP:0005406)2.77209912
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.77065177
37Clubbing of toes (HP:0100760)2.73467159
38Hepatic necrosis (HP:0002605)2.73454041
39Nephronophthisis (HP:0000090)2.71594988
40Abnormality of the renal cortex (HP:0011035)2.69830289
41Hepatocellular necrosis (HP:0001404)2.68776002
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.67689921
43Orchitis (HP:0100796)2.64063988
44Congenital sensorineural hearing impairment (HP:0008527)2.63241650
45Abnormal number of erythroid precursors (HP:0012131)2.58423679
46Eczematoid dermatitis (HP:0000976)2.57801216
47Large for gestational age (HP:0001520)2.56199909
48Ketosis (HP:0001946)2.55255672
49Meckel diverticulum (HP:0002245)2.54154855
50Petechiae (HP:0000967)2.53742277
51Abnormality of the ileum (HP:0001549)2.53303292
52Abnormality of macrophages (HP:0004311)2.52065298
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.51023431
54Hypothermia (HP:0002045)2.50909205
55Prolonged bleeding time (HP:0003010)2.49661371
56Microvesicular hepatic steatosis (HP:0001414)2.49577274
57Abnormal rod and cone electroretinograms (HP:0008323)2.48312665
58Abnormality of the fovea (HP:0000493)2.46535101
59Chronic hepatic failure (HP:0100626)2.46148546
60Pallor (HP:0000980)2.44616250
61IgM deficiency (HP:0002850)2.41342248
62Neoplasm of the adrenal cortex (HP:0100641)2.37113239
63Abnormal drinking behavior (HP:0030082)2.36454105
64Polydipsia (HP:0001959)2.36454105
65True hermaphroditism (HP:0010459)2.36003318
66Elevated erythrocyte sedimentation rate (HP:0003565)2.35888565
67Pendular nystagmus (HP:0012043)2.33948011
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33441012
69Abnormality of the prostate (HP:0008775)2.33333638
70Meningitis (HP:0001287)2.32932629
71Abnormality of the renal medulla (HP:0100957)2.31571020
72Bone marrow hypocellularity (HP:0005528)2.30732864
73Abnormality of cells of the erythroid lineage (HP:0012130)2.30278559
74Hypomagnesemia (HP:0002917)2.30213794
75Abnormality of chromosome stability (HP:0003220)2.30031461
76Decreased electroretinogram (ERG) amplitude (HP:0000654)2.29725425
77Exertional dyspnea (HP:0002875)2.27683935
78Abolished electroretinogram (ERG) (HP:0000550)2.22863529
79Pancreatic fibrosis (HP:0100732)2.21439574
80Aplasia/Hypoplasia of the macula (HP:0008059)2.20309432
81Prostate neoplasm (HP:0100787)2.20045973
82Hamartoma of the eye (HP:0010568)2.19504164
83Pancytopenia (HP:0001876)2.19461815
843-Methylglutaconic aciduria (HP:0003535)2.16778781
85Abnormality of vitamin B metabolism (HP:0004340)2.15493489
86Type 2 muscle fiber atrophy (HP:0003554)2.14838431
87Chronic mucocutaneous candidiasis (HP:0002728)2.14503740
88Recurrent cutaneous fungal infections (HP:0011370)2.14503740
89Decreased central vision (HP:0007663)2.14316861
90Myelodysplasia (HP:0002863)2.13351622
91Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13215040
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13215040
93Mediastinal lymphadenopathy (HP:0100721)2.12544214
94Cutaneous melanoma (HP:0012056)2.12431958
95Abnormal delayed hypersensitivity skin test (HP:0002963)2.12345917
96Abnormality of the columella (HP:0009929)2.11207150
97Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10750913
98Medial flaring of the eyebrow (HP:0010747)2.10263341
99Panhypogammaglobulinemia (HP:0003139)2.09862462
100Type II lissencephaly (HP:0007260)2.09501448
101Hypoproteinemia (HP:0003075)2.08905625
102Aplasia/hypoplasia of the uterus (HP:0008684)2.08644407
10311 pairs of ribs (HP:0000878)2.08305562
104Pancreatic cysts (HP:0001737)2.08074910
105Furrowed tongue (HP:0000221)2.06813030
106Encephalitis (HP:0002383)2.06698726
107Tubular atrophy (HP:0000092)2.06055593
108Recurrent fungal infections (HP:0002841)2.05886857
109Aplasia/Hypoplasia affecting the retina (HP:0008061)2.04567680
110Cheilitis (HP:0100825)2.00669950
111Optic disc pallor (HP:0000543)1.99502541
112Disproportionate short-trunk short stature (HP:0003521)1.96206948
113Severe visual impairment (HP:0001141)1.95999273
114Recurrent skin infections (HP:0001581)1.95576986
115* Albinism (HP:0001022)1.95187142
116Intestinal atresia (HP:0011100)1.93992659
117Renal Fanconi syndrome (HP:0001994)1.93145817
118Hypoplasia of the fovea (HP:0007750)1.92782829
119Aplasia/Hypoplasia of the fovea (HP:0008060)1.92782829
120Birth length less than 3rd percentile (HP:0003561)1.92641516
121Thrombocytosis (HP:0001894)1.92464014
122Meningioma (HP:0002858)1.92187599
123Increased serum lactate (HP:0002151)1.91735166
124Abnormality of the heme biosynthetic pathway (HP:0010472)1.90677193
125Thyroid-stimulating hormone excess (HP:0002925)1.90326967
126Patchy hypopigmentation of hair (HP:0011365)1.89772454
127Gaze-evoked nystagmus (HP:0000640)1.89699767
128Abnormal hair whorl (HP:0010721)1.87843289
129Muscle fiber atrophy (HP:0100295)1.87558007
130Increased hepatocellular lipid droplets (HP:0006565)1.87197256
131Attenuation of retinal blood vessels (HP:0007843)1.87044318
132Lethargy (HP:0001254)1.86822062
133Recurrent pneumonia (HP:0006532)1.86734728
134Hyperventilation (HP:0002883)1.86556436
135Hypoplasia of the uterus (HP:0000013)1.86468759
136Stomach cancer (HP:0012126)1.86307943
137Triphalangeal thumb (HP:0001199)1.86231170
138Acute lymphatic leukemia (HP:0006721)1.86131407
139Vacuolated lymphocytes (HP:0001922)1.85949171
140Macrocytic anemia (HP:0001972)1.85934769
141Lactic acidosis (HP:0003128)1.85427606
142Progressive microcephaly (HP:0000253)1.84873343
143Bile duct proliferation (HP:0001408)1.84830225
144Abnormal biliary tract physiology (HP:0012439)1.84830225
145Polyuria (HP:0000103)1.84754020
146Renal cortical cysts (HP:0000803)1.84196258
147Optic nerve coloboma (HP:0000588)1.82957097
148Abnormality of T cell physiology (HP:0011840)1.82867157
149Lymphoma (HP:0002665)1.82310797
150Absent thumb (HP:0009777)1.82009934
151Sclerocornea (HP:0000647)1.81478495
152Neoplasm of the adrenal gland (HP:0100631)1.80018856
153Gingivitis (HP:0000230)1.79760754
154Conjunctival hamartoma (HP:0100780)1.79612155
155Abnormality of urine glucose concentration (HP:0011016)1.78834494
156Glycosuria (HP:0003076)1.78834494
157Keratoconus (HP:0000563)1.77741303
158Increased corneal curvature (HP:0100692)1.77741303
159Cystic liver disease (HP:0006706)1.77393735
160Ectopic kidney (HP:0000086)1.77239433
161IgG deficiency (HP:0004315)1.76449222
162Cerebral edema (HP:0002181)1.75540433
163Abnormality of renal resorption (HP:0011038)1.74399852
164Abnormality of the vitamin B12 metabolism (HP:0004341)1.73544095
165Small intestinal stenosis (HP:0012848)1.73461641
166Duodenal stenosis (HP:0100867)1.73461641
167Keratoconjunctivitis sicca (HP:0001097)1.73402194
168White forelock (HP:0002211)1.72980136
169Severe muscular hypotonia (HP:0006829)1.72867728
170Hematochezia (HP:0002573)1.71881958
171Thyroiditis (HP:0100646)1.71481614
172Respiratory failure (HP:0002878)1.68670160
173Hyperglycemia (HP:0003074)1.68522847
174Parakeratosis (HP:0001036)1.67609338
175Lipid accumulation in hepatocytes (HP:0006561)1.67371333
176Aplasia/Hypoplasia of the tongue (HP:0010295)1.67229997
177Abnormality of magnesium homeostasis (HP:0004921)1.66705567
178Tongue fasciculations (HP:0001308)1.65970162
179Agitation (HP:0000713)1.65035243
180Tachypnea (HP:0002789)1.64495217
181Concave nail (HP:0001598)1.64171289
182Abnormality of the labia minora (HP:0012880)1.63442671

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.21534517
2STK164.33879489
3IRAK33.61261183
4IRAK43.60730693
5MAP4K23.23760871
6TNIK3.08338285
7TLK13.05480343
8MST42.94282020
9EIF2AK12.93349949
10ZAK2.89765947
11TRIM282.79588819
12TEC2.39452431
13VRK12.24460925
14TXK2.23567323
15PIM22.22528788
16PINK12.21853352
17BLK1.99900315
18SRPK11.97121909
19PLK41.94008469
20KIT1.88358739
21WNK31.87156655
22MAP3K141.86903150
23EIF2AK21.82785449
24MAPKAPK31.81787596
25BMPR1B1.80710568
26VRK21.76216957
27FLT31.75676479
28NME21.74137182
29CDK191.73902093
30PAK31.67650376
31PLK21.60609438
32WEE11.60543596
33MKNK21.56424852
34BTK1.55329091
35FGFR21.51985786
36ADRBK21.48227207
37MAP4K11.42673502
38NLK1.38001853
39BRSK21.34299579
40IKBKB1.33203795
41PRKCI1.28927439
42MKNK11.26191573
43FER1.26067429
44YES11.25017268
45IRAK11.22016857
46OXSR11.21971177
47IKBKE1.19984754
48JAK31.18849655
49STK241.17916271
50BCKDK1.16803877
51STK391.15263840
52CASK1.10745471
53BUB11.09519895
54INSRR1.09183760
55PRKD31.08214390
56CDK81.06218284
57DYRK31.04424333
58EIF2AK31.03910925
59WNK41.03612306
60SIK31.02705444
61PASK0.99936700
62MAP2K70.98386076
63MUSK0.98055098
64ADRBK10.97815775
65GRK10.96732610
66CLK10.96018461
67TYK20.92837994
68MARK30.92489843
69LIMK10.92015538
70PRKCE0.89315800
71PTK2B0.88130658
72ATR0.87644974
73LYN0.86949382
74SYK0.86273599
75STK100.85834669
76MAP2K60.81460349
77ZAP700.81436647
78PHKG10.80662498
79PHKG20.80662498
80BMPR20.80147868
81CDK70.78507530
82MAPK130.78201866
83CSF1R0.77556287
84CSNK1G20.76340735
85CSNK1G30.75494257
86GRK70.73852523
87PIM10.72784381
88STK30.70562386
89HIPK20.70422565
90PRKCG0.69561704
91CHUK0.67823458
92STK38L0.65893239
93EPHA30.65623074
94CSNK1G10.64329454
95BRAF0.63373094
96NME10.62932511
97FES0.62237652
98DYRK20.59532939
99PRKCQ0.59529239
100IRAK20.59382069
101ACVR1B0.58295967
102TAOK30.57244350
103LCK0.57134335
104NEK60.56944810
105CHEK20.56590748
106TNK20.55276621
107CAMKK20.54967452
108PDK20.54791409
109GRK50.54147120
110ERBB30.53821716
111MAP2K10.51446068
112PLK10.50139147
113TGFBR10.49508698
114NEK90.49246433
115MATK0.48909780
116DAPK20.48221317
117PRKCH0.47293903
118EPHA20.45541461
119MAP3K40.44812386
120TBK10.44489459
121MAPK150.44321384
122STK40.43290043
123CSNK1A1L0.43039061
124TAOK20.41843700
125HCK0.41342116
126TTK0.40566479
127ABL10.39335927
128CCNB10.38830896
129MAPK40.38642951
130RPS6KB20.38315963
131PLK30.38250952
132AURKA0.36474596
133MAP3K130.36392467
134RPS6KA50.35894045
135CSNK2A10.34875902
136PRKCD0.34616546
137DAPK10.34067645
138BRSK10.33953695
139CAMK10.33354953
140TRPM70.33097582
141NUAK10.32314071
142MAPKAPK50.32138772
143TAF10.31781616
144RPS6KA60.31358353
145RPS6KC10.29868503
146RPS6KL10.29868503
147CDK30.29619879
148PRKCZ0.29072861
149ITK0.28040660
150TIE10.27767636
151MAP3K120.27025144
152PRKAA20.26754300
153GRK60.26482641
154TSSK60.26370480

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.21513795
2Ribosome_Homo sapiens_hsa030103.19060277
3Homologous recombination_Homo sapiens_hsa034402.77926442
4Sulfur metabolism_Homo sapiens_hsa009202.76266813
5Oxidative phosphorylation_Homo sapiens_hsa001902.70843076
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.56287883
7Base excision repair_Homo sapiens_hsa034102.55550516
8Fanconi anemia pathway_Homo sapiens_hsa034602.53841489
9RNA polymerase_Homo sapiens_hsa030202.51682159
10Mismatch repair_Homo sapiens_hsa034302.44238215
11Phototransduction_Homo sapiens_hsa047442.36444810
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32627820
13Pyrimidine metabolism_Homo sapiens_hsa002402.08429563
14Butanoate metabolism_Homo sapiens_hsa006502.08267850
15Protein export_Homo sapiens_hsa030602.00350229
16Collecting duct acid secretion_Homo sapiens_hsa049661.98691992
17Parkinsons disease_Homo sapiens_hsa050121.94074722
18Nucleotide excision repair_Homo sapiens_hsa034201.82997409
19Selenocompound metabolism_Homo sapiens_hsa004501.81280499
20Type I diabetes mellitus_Homo sapiens_hsa049401.81226724
21Fatty acid elongation_Homo sapiens_hsa000621.75612005
22Non-homologous end-joining_Homo sapiens_hsa034501.73307235
23Proteasome_Homo sapiens_hsa030501.72605857
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69433332
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.68928800
26Other glycan degradation_Homo sapiens_hsa005111.67166201
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64758844
28Primary immunodeficiency_Homo sapiens_hsa053401.63430275
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56037455
30Peroxisome_Homo sapiens_hsa041461.52318818
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52038075
32Spliceosome_Homo sapiens_hsa030401.50941224
33Propanoate metabolism_Homo sapiens_hsa006401.46448511
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.45384032
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44406907
36Hematopoietic cell lineage_Homo sapiens_hsa046401.41698902
37Basal transcription factors_Homo sapiens_hsa030221.40684080
38Leishmaniasis_Homo sapiens_hsa051401.40233561
39Tryptophan metabolism_Homo sapiens_hsa003801.38770703
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38094695
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37015077
42Herpes simplex infection_Homo sapiens_hsa051681.35800998
43Measles_Homo sapiens_hsa051621.34405993
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31216939
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.31121937
46p53 signaling pathway_Homo sapiens_hsa041151.28821141
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26835816
48Purine metabolism_Homo sapiens_hsa002301.23736345
49Ether lipid metabolism_Homo sapiens_hsa005651.23722892
50Arachidonic acid metabolism_Homo sapiens_hsa005901.19847149
51Caffeine metabolism_Homo sapiens_hsa002321.18415932
52Alzheimers disease_Homo sapiens_hsa050101.16498269
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15962743
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15453805
55Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14262543
56Nitrogen metabolism_Homo sapiens_hsa009101.12859958
57Sphingolipid metabolism_Homo sapiens_hsa006001.11555518
58Graft-versus-host disease_Homo sapiens_hsa053321.11530903
59NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04593553
60Cell cycle_Homo sapiens_hsa041101.04185677
61One carbon pool by folate_Homo sapiens_hsa006701.04054366
62Allograft rejection_Homo sapiens_hsa053301.01986282
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00358917
64Autoimmune thyroid disease_Homo sapiens_hsa053200.99248435
65RNA degradation_Homo sapiens_hsa030180.99150703
66Pertussis_Homo sapiens_hsa051330.97501269
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94834006
68N-Glycan biosynthesis_Homo sapiens_hsa005100.94516498
69Vitamin B6 metabolism_Homo sapiens_hsa007500.92954510
70Glutathione metabolism_Homo sapiens_hsa004800.92791277
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91930006
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.91113954
73Sulfur relay system_Homo sapiens_hsa041220.88660167
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88188423
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87809415
76Chemical carcinogenesis_Homo sapiens_hsa052040.87599144
77Folate biosynthesis_Homo sapiens_hsa007900.86930032
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86896919
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85344840
80Influenza A_Homo sapiens_hsa051640.83191352
81Epstein-Barr virus infection_Homo sapiens_hsa051690.82551859
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82522373
83Regulation of autophagy_Homo sapiens_hsa041400.81168259
84Steroid biosynthesis_Homo sapiens_hsa001000.79442481
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78578599
86Legionellosis_Homo sapiens_hsa051340.77035654
87beta-Alanine metabolism_Homo sapiens_hsa004100.76188460
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.74972602
89RNA transport_Homo sapiens_hsa030130.73527026
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.73266298
91Antigen processing and presentation_Homo sapiens_hsa046120.73171955
92Tuberculosis_Homo sapiens_hsa051520.73124336
93Metabolic pathways_Homo sapiens_hsa011000.70830455
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70547949
95Systemic lupus erythematosus_Homo sapiens_hsa053220.70091884
96Rheumatoid arthritis_Homo sapiens_hsa053230.68122184
97Glycerolipid metabolism_Homo sapiens_hsa005610.67873597
98Mineral absorption_Homo sapiens_hsa049780.67373702
99Asthma_Homo sapiens_hsa053100.67178896
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67000359
101Osteoclast differentiation_Homo sapiens_hsa043800.65393972
102Apoptosis_Homo sapiens_hsa042100.65132772
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.64698380
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64057005
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63910786
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63825295
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61884334
108Malaria_Homo sapiens_hsa051440.61842970
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58913410
110ABC transporters_Homo sapiens_hsa020100.58296463
111B cell receptor signaling pathway_Homo sapiens_hsa046620.57893459
112Shigellosis_Homo sapiens_hsa051310.57448771
113Hepatitis B_Homo sapiens_hsa051610.54887332
114TNF signaling pathway_Homo sapiens_hsa046680.53176313
115Olfactory transduction_Homo sapiens_hsa047400.51975931
116Insulin secretion_Homo sapiens_hsa049110.51893353
117Fatty acid metabolism_Homo sapiens_hsa012120.49914884
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49439880
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49382646
120Acute myeloid leukemia_Homo sapiens_hsa052210.49328800
121Vitamin digestion and absorption_Homo sapiens_hsa049770.49054159
122Lysosome_Homo sapiens_hsa041420.48898882
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48785632
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47385511
125Fatty acid degradation_Homo sapiens_hsa000710.45914782
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45690214
127Linoleic acid metabolism_Homo sapiens_hsa005910.45443162
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45340161
129mRNA surveillance pathway_Homo sapiens_hsa030150.45263967
130Ovarian steroidogenesis_Homo sapiens_hsa049130.45057937
131Fat digestion and absorption_Homo sapiens_hsa049750.44832868
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44653036
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.41627492
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41386172
135Huntingtons disease_Homo sapiens_hsa050160.39881200
136Retinol metabolism_Homo sapiens_hsa008300.39736065
137Toxoplasmosis_Homo sapiens_hsa051450.39270932
138Hepatitis C_Homo sapiens_hsa051600.38632749
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38505286
140Renin-angiotensin system_Homo sapiens_hsa046140.35455567
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.35022339
142Phagosome_Homo sapiens_hsa041450.34912491
143Pentose phosphate pathway_Homo sapiens_hsa000300.34815499
144Staphylococcus aureus infection_Homo sapiens_hsa051500.34796735
145Chemokine signaling pathway_Homo sapiens_hsa040620.33979012
146Cardiac muscle contraction_Homo sapiens_hsa042600.33536574
147Dorso-ventral axis formation_Homo sapiens_hsa043200.32118081

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