BLOC1S4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and is a model for Hermansky-Pudlak syndrome. The encoded protein may play a role in intracellular vesicular trafficking. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.74474912
2ribosomal small subunit biogenesis (GO:0042274)6.13716325
3viral transcription (GO:0019083)5.94731466
4positive regulation of prostaglandin secretion (GO:0032308)5.92044211
5translational termination (GO:0006415)5.73706790
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.04923098
7regulation of prostaglandin secretion (GO:0032306)4.98595691
8protein targeting to ER (GO:0045047)4.95748421
9cotranslational protein targeting to membrane (GO:0006613)4.94948976
10translational elongation (GO:0006414)4.94807449
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.90702267
12ATP synthesis coupled proton transport (GO:0015986)4.90702267
13base-excision repair, AP site formation (GO:0006285)4.87097522
14protein localization to endoplasmic reticulum (GO:0070972)4.72679838
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.69420263
16ribosomal small subunit assembly (GO:0000028)4.66690041
17ribonucleoprotein complex biogenesis (GO:0022613)4.55934144
18translational initiation (GO:0006413)4.55298298
19protein neddylation (GO:0045116)4.53400298
20pyrimidine nucleotide catabolic process (GO:0006244)4.53014894
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.51577350
22viral life cycle (GO:0019058)4.50564324
23maturation of SSU-rRNA (GO:0030490)4.44239384
24ribosomal large subunit biogenesis (GO:0042273)4.43852688
25cellular protein complex disassembly (GO:0043624)4.30383716
26proteasome assembly (GO:0043248)4.29971774
27deoxyribonucleotide catabolic process (GO:0009264)4.13504639
28pseudouridine synthesis (GO:0001522)4.12362980
29ribosome biogenesis (GO:0042254)4.05268111
30deoxyribose phosphate catabolic process (GO:0046386)3.97242718
31metallo-sulfur cluster assembly (GO:0031163)3.95770670
32iron-sulfur cluster assembly (GO:0016226)3.95770670
33regulation of mitochondrial translation (GO:0070129)3.91193664
34rRNA modification (GO:0000154)3.84696501
35protein complex biogenesis (GO:0070271)3.83592589
36translation (GO:0006412)3.82219414
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.81611098
38NADH dehydrogenase complex assembly (GO:0010257)3.81611098
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.81611098
40rRNA processing (GO:0006364)3.80916619
41regulation of glucocorticoid secretion (GO:2000849)3.73932231
42electron transport chain (GO:0022900)3.72459430
43respiratory electron transport chain (GO:0022904)3.70798723
44formation of translation preinitiation complex (GO:0001731)3.70268378
45positive regulation of icosanoid secretion (GO:0032305)3.68921480
46protein complex disassembly (GO:0043241)3.68804279
47telomere maintenance via semi-conservative replication (GO:0032201)3.64264828
48DNA strand elongation involved in DNA replication (GO:0006271)3.63582683
49rRNA metabolic process (GO:0016072)3.63337455
50folic acid-containing compound biosynthetic process (GO:0009396)3.59278236
51mitochondrial respiratory chain complex assembly (GO:0033108)3.58687806
52cellular component biogenesis (GO:0044085)3.55879075
53folic acid metabolic process (GO:0046655)3.54335451
54pteridine-containing compound biosynthetic process (GO:0042559)3.48802955
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.48571420
56macromolecular complex disassembly (GO:0032984)3.47574070
572-deoxyribonucleotide metabolic process (GO:0009394)3.41473368
58DNA replication initiation (GO:0006270)3.37465922
59purine deoxyribonucleotide catabolic process (GO:0009155)3.36591555
60protein targeting to membrane (GO:0006612)3.36159219
61nuclear-transcribed mRNA catabolic process (GO:0000956)3.35880126
62DNA strand elongation (GO:0022616)3.35873439
63positive regulation of fatty acid transport (GO:2000193)3.31265373
64establishment of protein localization to mitochondrial membrane (GO:0090151)3.24547745
65spliceosomal snRNP assembly (GO:0000387)3.24540463
66pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.23588098
67deoxyribose phosphate metabolic process (GO:0019692)3.23374945
68GTP biosynthetic process (GO:0006183)3.22241441
69mRNA catabolic process (GO:0006402)3.19903544
70oxidative phosphorylation (GO:0006119)3.13345927
71protein targeting to mitochondrion (GO:0006626)3.13083225
72rRNA methylation (GO:0031167)3.11433097
73DNA replication checkpoint (GO:0000076)3.10385363
74RNA catabolic process (GO:0006401)3.09543078
75deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.09363481
76histone arginine methylation (GO:0034969)3.06322742
77establishment of protein localization to mitochondrion (GO:0072655)3.05253858
78cytochrome complex assembly (GO:0017004)3.04029194
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.02997571
80tRNA processing (GO:0008033)3.02781792
81L-serine metabolic process (GO:0006563)2.99376500
82regulation of appetite (GO:0032098)2.98747690
83peptidyl-arginine omega-N-methylation (GO:0035247)2.97916902
84UTP biosynthetic process (GO:0006228)2.97813833
85DNA replication-dependent nucleosome assembly (GO:0006335)2.97414446
86DNA replication-dependent nucleosome organization (GO:0034723)2.97414446
87ncRNA 3-end processing (GO:0043628)2.92408681
88purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.92216713
89purine nucleoside triphosphate biosynthetic process (GO:0009145)2.91382207
90respiratory chain complex IV assembly (GO:0008535)2.89796091
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86818652
92telomere maintenance via recombination (GO:0000722)2.86765245
93protein deneddylation (GO:0000338)2.86717721
94establishment of protein localization to membrane (GO:0090150)2.86140904
95transcription from mitochondrial promoter (GO:0006390)2.85398400
96transcription elongation from RNA polymerase III promoter (GO:0006385)2.85126568
97termination of RNA polymerase III transcription (GO:0006386)2.85126568
98tRNA modification (GO:0006400)2.83655073
99nucleobase biosynthetic process (GO:0046112)2.83198628
100ATP biosynthetic process (GO:0006754)2.82735220
101pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.81935731
102negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81488845
103nuclear envelope reassembly (GO:0031468)2.81338898
104mitotic nuclear envelope reassembly (GO:0007084)2.81338898
105negative regulation of ligase activity (GO:0051352)2.80721695
106negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.80721695
107protein-cofactor linkage (GO:0018065)2.80305857
108purine nucleobase biosynthetic process (GO:0009113)2.79999144
109regulation of corticosteroid hormone secretion (GO:2000846)2.79783990
110ribosome assembly (GO:0042255)2.78707545
111protein maturation by protein folding (GO:0022417)2.78610879
112pentose-phosphate shunt (GO:0006098)2.75980326
113heme biosynthetic process (GO:0006783)2.75803071
114protein localization to mitochondrion (GO:0070585)2.75083895
115mitotic recombination (GO:0006312)2.74205307
116nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73256230
117deoxyribonucleotide metabolic process (GO:0009262)2.72438717
118regulation of icosanoid secretion (GO:0032303)2.71253229
119guanosine-containing compound biosynthetic process (GO:1901070)2.70767514
120exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70694377
121mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.70594199
122DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69886182
123nucleobase-containing small molecule interconversion (GO:0015949)2.69791623
124tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69384204
125RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69384204
126deoxyribose phosphate biosynthetic process (GO:0046385)2.69377499
1272-deoxyribonucleotide biosynthetic process (GO:0009265)2.69377499
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.66000873
129protein localization to kinetochore (GO:0034501)2.65519693
130intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63366024
131signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.63366024
132chaperone-mediated protein transport (GO:0072321)2.63131864
133mitochondrial DNA metabolic process (GO:0032042)2.62681193
134ncRNA processing (GO:0034470)2.62427360
135pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.61872943
136serine family amino acid biosynthetic process (GO:0009070)2.59581291
137L-methionine salvage (GO:0071267)2.58582383
138L-methionine biosynthetic process (GO:0071265)2.58582383
139amino acid salvage (GO:0043102)2.58582383
140signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.58000623
141signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.58000623
142signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.58000623
143rRNA transcription (GO:0009303)2.56916572
144regulation of protein heterodimerization activity (GO:0043497)2.56901937
145pteridine-containing compound metabolic process (GO:0042558)2.56413405
146cullin deneddylation (GO:0010388)2.56249478
147antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.55630804
148protein targeting (GO:0006605)2.55188198
149interferon-gamma production (GO:0032609)2.53899092
150mitochondrial RNA metabolic process (GO:0000959)2.52771167
151signal transduction involved in DNA integrity checkpoint (GO:0072401)2.52392108
152signal transduction involved in DNA damage checkpoint (GO:0072422)2.52392108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.64713082
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.10946189
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.09803090
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.97782426
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.93108964
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91527992
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.84524862
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82378258
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78139146
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72367810
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.63132279
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.57762767
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49756930
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48427188
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.22951923
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17724949
17XRN2_22483619_ChIP-Seq_HELA_Human2.14496436
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13814543
19VDR_23849224_ChIP-Seq_CD4+_Human2.09754489
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08639299
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.02765556
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02386985
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01752669
24DCP1A_22483619_ChIP-Seq_HELA_Human1.94452115
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93692497
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85116135
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81301261
28GABP_19822575_ChIP-Seq_HepG2_Human1.74861875
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.74527310
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73529505
31MYC_22102868_ChIP-Seq_BL_Human1.72352673
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.69652718
33CIITA_25753668_ChIP-Seq_RAJI_Human1.69619664
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.68590474
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.68590474
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.68590474
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68308812
38VDR_21846776_ChIP-Seq_THP-1_Human1.66405157
39FOXP3_21729870_ChIP-Seq_TREG_Human1.66312294
40TTF2_22483619_ChIP-Seq_HELA_Human1.63100258
41ZNF263_19887448_ChIP-Seq_K562_Human1.60081643
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.60052260
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59998149
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53464794
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52849101
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51210284
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.48806174
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47571701
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46273609
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44854171
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44699529
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44673070
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41461619
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39829726
55CTCF_18555785_ChIP-Seq_MESCs_Mouse1.35889859
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34037548
57SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.31050771
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.30738112
59FOXP1_21924763_ChIP-Seq_HESCs_Human1.30515672
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29986970
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28934909
62SPI1_23547873_ChIP-Seq_NB4_Human1.26847638
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.25094594
64KDM5A_27292631_Chip-Seq_BREAST_Human1.23768958
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23051666
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22444128
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22358119
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21161092
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.20778692
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.19096058
71TFEB_21752829_ChIP-Seq_HELA_Human1.18857485
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18525113
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17874859
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17185492
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17176668
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15959227
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15899338
78CTCF_26484167_Chip-Seq_Bcells_Mouse1.15759662
79IRF8_22096565_ChIP-ChIP_GC-B_Human1.14938080
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.14776858
81ELK1_19687146_ChIP-ChIP_HELA_Human1.14158877
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13828789
83MYC_18940864_ChIP-ChIP_HL60_Human1.13729619
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12179737
85CTCF_21964334_Chip-Seq_Bcells_Human1.12022426
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11962278
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11586176
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10684772
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10433914
90BCL6_27268052_Chip-Seq_Bcells_Human1.10272216
91MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10106112
92EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09690245
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09511329
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09418550
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09273095
96P68_20966046_ChIP-Seq_HELA_Human1.09057807
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08870701
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08405193
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07797885
100IRF8_21731497_ChIP-ChIP_J774_Mouse1.06221610
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05762847
102RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05522947
103BP1_19119308_ChIP-ChIP_Hs578T_Human1.03351392
104* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03030112
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02846828
106E2F1_21310950_ChIP-Seq_MCF-7_Human1.02695249
107OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02164924
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01663461
109SA1_27219007_Chip-Seq_Bcells_Human1.00204729
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99853438
111RUNX1_22412390_ChIP-Seq_EML_Mouse0.99787747
112LXR_22292898_ChIP-Seq_THP-1_Human0.99446495
113GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99109827
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98838460
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98793505
116MAF_26560356_Chip-Seq_TH2_Human0.96966701
117CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96559046
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96515682
119YY1_22570637_ChIP-Seq_MALME-3M_Human0.95116326
120MAF_26560356_Chip-Seq_TH1_Human0.94936442
121STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94411440
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94131986
123VDR_24763502_ChIP-Seq_THP-1_Human0.94102398
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94054457
125UTX_26944678_Chip-Seq_JUKART_Human0.93771343
126TP63_19390658_ChIP-ChIP_HaCaT_Human0.93189013
127MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91894034
128STAT1_20625510_ChIP-Seq_HELA_Human0.90515035
129FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90066789
130SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89768545
131SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89429274

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology3.56329922
2MP0002102_abnormal_ear_morphology3.46412032
3MP0004957_abnormal_blastocyst_morpholog3.44036983
4MP0003693_abnormal_embryo_hatching3.13005385
5MP0009333_abnormal_splenocyte_physiolog2.74297585
6MP0008057_abnormal_DNA_replication2.55566630
7MP0003436_decreased_susceptibility_to2.54945329
8MP0003656_abnormal_erythrocyte_physiolo2.47313443
9MP0003806_abnormal_nucleotide_metabolis2.31633229
10MP0010094_abnormal_chromosome_stability2.30742008
11MP0010030_abnormal_orbit_morphology2.27256329
12MP0004858_abnormal_nervous_system2.24800662
13MP0006082_CNS_inflammation2.20889075
14MP0000685_abnormal_immune_system2.18987071
15MP0003111_abnormal_nucleus_morphology2.18929384
16MP0005379_endocrine/exocrine_gland_phen2.12899394
17MP0003077_abnormal_cell_cycle2.11550491
18MP0003186_abnormal_redox_activity2.03692114
19MP0009379_abnormal_foot_pigmentation2.02328190
20MP0003303_peritoneal_inflammation1.98070727
21MP0001905_abnormal_dopamine_level1.97447607
22MP0002396_abnormal_hematopoietic_system1.93255588
23MP0009785_altered_susceptibility_to1.91167262
24MP0005000_abnormal_immune_tolerance1.85930923
25MP0000490_abnormal_crypts_of1.82367328
26MP0008932_abnormal_embryonic_tissue1.82352256
27MP0002653_abnormal_ependyma_morphology1.81970150
28MP0002398_abnormal_bone_marrow1.77927529
29MP0000689_abnormal_spleen_morphology1.77627909
30MP0005025_abnormal_response_to1.72946435
31MP0003724_increased_susceptibility_to1.72311007
32MP0006036_abnormal_mitochondrial_physio1.70688020
33MP0001968_abnormal_touch/_nociception1.70261010
34MP0003011_delayed_dark_adaptation1.68968649
35MP0002722_abnormal_immune_system1.68820838
36MP0008007_abnormal_cellular_replicative1.68329292
37MP0001800_abnormal_humoral_immune1.65955527
38MP0001346_abnormal_lacrimal_gland1.65900797
39MP0005075_abnormal_melanosome_morpholog1.64200460
40MP0001835_abnormal_antigen_presentation1.63676057
41MP0008789_abnormal_olfactory_epithelium1.62937326
42MP0003763_abnormal_thymus_physiology1.61045343
43MP0001545_abnormal_hematopoietic_system1.60788357
44MP0005397_hematopoietic_system_phenotyp1.60788357
45MP0002723_abnormal_immune_serum1.60234341
46MP0005671_abnormal_response_to1.57764952
47MP0006035_abnormal_mitochondrial_morpho1.57580370
48MP0008058_abnormal_DNA_repair1.57488434
49MP0002452_abnormal_antigen_presenting1.56613523
50MP0009840_abnormal_foam_cell1.55178961
51MP0000350_abnormal_cell_proliferation1.54732486
52MP0002420_abnormal_adaptive_immunity1.53983258
53MP0002277_abnormal_respiratory_mucosa1.52975826
54MP0002429_abnormal_blood_cell1.52594168
55MP0001819_abnormal_immune_cell1.52109974
56MP0000716_abnormal_immune_system1.49942668
57MP0002405_respiratory_system_inflammati1.47297590
58MP0002909_abnormal_adrenal_gland1.44982598
59MP0002132_abnormal_respiratory_system1.44290707
60MP0005645_abnormal_hypothalamus_physiol1.43129237
61MP0001853_heart_inflammation1.42139698
62MP0002138_abnormal_hepatobiliary_system1.41930932
63MP0002019_abnormal_tumor_incidence1.40091924
64MP0000371_diluted_coat_color1.39064263
65MP0002148_abnormal_hypersensitivity_rea1.35422659
66MP0000703_abnormal_thymus_morphology1.33379095
67MP0000358_abnormal_cell_content/1.32349056
68MP0000858_altered_metastatic_potential1.31801699
69MP0001790_abnormal_immune_system1.28106916
70MP0005387_immune_system_phenotype1.28106916
71MP0000313_abnormal_cell_death1.27998537
72MP0000049_abnormal_middle_ear1.27193362
73MP0002419_abnormal_innate_immunity1.27113451
74MP0000465_gastrointestinal_hemorrhage1.26945735
75MP0005394_taste/olfaction_phenotype1.26934332
76MP0005499_abnormal_olfactory_system1.26934332
77MP0005084_abnormal_gallbladder_morpholo1.26818823
78MP0008995_early_reproductive_senescence1.25811057
79MP0008469_abnormal_protein_level1.24103851
80MP0003122_maternal_imprinting1.23844530
81MP0003718_maternal_effect1.22674071
82MP0003787_abnormal_imprinting1.18737903
83MP0001730_embryonic_growth_arrest1.18326087
84MP0010352_gastrointestinal_tract_polyps1.16924713
85MP0003121_genomic_imprinting1.14920203
86MP0005451_abnormal_body_composition1.14124170
87MP0002938_white_spotting1.12347863
88MP0000566_synostosis1.11356467
89MP0003221_abnormal_cardiomyocyte_apopto1.09443524
90MP0000639_abnormal_adrenal_gland1.08546323
91MP0005464_abnormal_platelet_physiology1.07813804
92MP0001845_abnormal_inflammatory_respons1.05624985
93MP0003136_yellow_coat_color1.05562650
94MP0001873_stomach_inflammation1.05385990
95MP0002080_prenatal_lethality1.04171422
96MP0001186_pigmentation_phenotype1.02678268
97MP0000343_altered_response_to1.01881990
98MP0002075_abnormal_coat/hair_pigmentati1.00673962
99MP0003786_premature_aging1.00445417
100MP0004133_heterotaxia0.99809630
101MP0003448_altered_tumor_morphology0.96717390
102MP0009765_abnormal_xenobiotic_induced0.96373780
103MP0002166_altered_tumor_susceptibility0.96130741
104MP0005174_abnormal_tail_pigmentation0.95929679
105MP0008873_increased_physiological_sensi0.95147872
106MP0001727_abnormal_embryo_implantation0.94298607
107MP0009764_decreased_sensitivity_to0.93569838
108MP0004808_abnormal_hematopoietic_stem0.93458815
109MP0002160_abnormal_reproductive_system0.92972088
110MP0000609_abnormal_liver_physiology0.92220047
111MP0000598_abnormal_liver_morphology0.92148380
112MP0001697_abnormal_embryo_size0.90886857
113MP0004142_abnormal_muscle_tone0.89577114
114MP0005058_abnormal_lysosome_morphology0.89150148
115MP0006292_abnormal_olfactory_placode0.88547409
116MP0005380_embryogenesis_phenotype0.87704290
117MP0001672_abnormal_embryogenesis/_devel0.87704290
118MP0005083_abnormal_biliary_tract0.86281481
119MP0005266_abnormal_metabolism0.86101531
120MP0000372_irregular_coat_pigmentation0.85987505
121MP0001533_abnormal_skeleton_physiology0.85802211
122MP0009763_increased_sensitivity_to0.85507763
123MP0001919_abnormal_reproductive_system0.85147118
124MP0005319_abnormal_enzyme/_coenzyme0.84632172
125MP0003315_abnormal_perineum_morphology0.84462414
126MP0009278_abnormal_bone_marrow0.84349950
127MP0004947_skin_inflammation0.84002610
128MP0003984_embryonic_growth_retardation0.83447487
129MP0002006_tumorigenesis0.82507888
130MP0002088_abnormal_embryonic_growth/wei0.81600617
131MP0003123_paternal_imprinting0.81513658
132MP0000604_amyloidosis0.81186224
133MP0002332_abnormal_exercise_endurance0.80828110
134MP0005389_reproductive_system_phenotype0.79575558
135MP0001529_abnormal_vocalization0.79191327
136MP0010155_abnormal_intestine_physiology0.77245114
137MP0005501_abnormal_skin_physiology0.76282658
138MP0000613_abnormal_salivary_gland0.76027017
139MP0002970_abnormal_white_adipose0.75620222
140MP0002234_abnormal_pharynx_morphology0.74675899
141MP0002085_abnormal_embryonic_tissue0.73580416
142MP0003329_amyloid_beta_deposits0.72008379
143MP0003453_abnormal_keratinocyte_physiol0.71676328
144MP0000470_abnormal_stomach_morphology0.71466223

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.60711803
2Abnormal number of erythroid precursors (HP:0012131)5.43886943
3Hypoglycemic seizures (HP:0002173)5.10013717
4Multiple enchondromatosis (HP:0005701)4.33701255
5Macrocytic anemia (HP:0001972)3.91177951
6Pallor (HP:0000980)3.61672781
7Symptomatic seizures (HP:0011145)3.54150459
8Progressive macrocephaly (HP:0004481)3.54016344
9Aplastic anemia (HP:0001915)3.47027579
10Elevated erythrocyte sedimentation rate (HP:0003565)3.46679384
11Trismus (HP:0000211)3.39466653
123-Methylglutaconic aciduria (HP:0003535)3.37109877
13Reticulocytopenia (HP:0001896)3.35624261
14Progressive muscle weakness (HP:0003323)3.16595781
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.09892000
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.09892000
17Aplasia/Hypoplasia of the sacrum (HP:0008517)3.03901648
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.98231339
19Microretrognathia (HP:0000308)2.96585545
20Reduced antithrombin III activity (HP:0001976)2.90665332
21Lactic acidosis (HP:0003128)2.85715027
22Hepatocellular necrosis (HP:0001404)2.77452850
23Abnormal hemoglobin (HP:0011902)2.76006156
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.71935706
25Exercise intolerance (HP:0003546)2.67376625
26Cerebral edema (HP:0002181)2.65142243
27Increased serum lactate (HP:0002151)2.61819115
28Abnormality of the heme biosynthetic pathway (HP:0010472)2.57709367
29Respiratory failure (HP:0002878)2.50318941
30Cerebral hypomyelination (HP:0006808)2.49295890
31Increased hepatocellular lipid droplets (HP:0006565)2.46082632
32Hepatic necrosis (HP:0002605)2.46073046
33Increased serum ferritin (HP:0003281)2.44955303
34Ragged-red muscle fibers (HP:0003200)2.42363856
35Increased intramyocellular lipid droplets (HP:0012240)2.39733194
36Abnormality of T cell physiology (HP:0011840)2.38243606
37Increased IgM level (HP:0003496)2.37873568
38Mitochondrial inheritance (HP:0001427)2.37737912
39Hypertensive crisis (HP:0100735)2.37717849
40Oral leukoplakia (HP:0002745)2.35064949
41Panhypogammaglobulinemia (HP:0003139)2.33860509
42Exertional dyspnea (HP:0002875)2.33714910
43Abnormality of glycolysis (HP:0004366)2.33411094
44Increased serum pyruvate (HP:0003542)2.33411094
45Chronic mucocutaneous candidiasis (HP:0002728)2.31259203
46Recurrent cutaneous fungal infections (HP:0011370)2.31259203
47Birth length less than 3rd percentile (HP:0003561)2.28590571
48Breast hypoplasia (HP:0003187)2.28467344
49Rough bone trabeculation (HP:0100670)2.28283929
50Poor head control (HP:0002421)2.27795804
51Respiratory difficulties (HP:0002880)2.26695404
52Broad distal phalanx of finger (HP:0009836)2.24888560
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23478330
54Abnormality of alanine metabolism (HP:0010916)2.23478330
55Hyperalaninemia (HP:0003348)2.23478330
56Abnormality of the anterior horn cell (HP:0006802)2.22049716
57Degeneration of anterior horn cells (HP:0002398)2.22049716
58Combined immunodeficiency (HP:0005387)2.20310254
59Dysphonia (HP:0001618)2.19748139
60Microvesicular hepatic steatosis (HP:0001414)2.19569058
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17822406
62Lipid accumulation in hepatocytes (HP:0006561)2.17396517
63Pancytopenia (HP:0001876)2.16172080
64Partial duplication of thumb phalanx (HP:0009944)2.15040325
65Severe visual impairment (HP:0001141)2.14585379
66Petechiae (HP:0000967)2.14409619
67Increased CSF lactate (HP:0002490)2.14153400
68Recurrent fungal infections (HP:0002841)2.13542060
69Abnormal cartilage morphology (HP:0002763)2.11425233
70Type I transferrin isoform profile (HP:0003642)2.09944637
71Cleft eyelid (HP:0000625)2.06966957
72Glossoptosis (HP:0000162)2.01451440
73Polyphagia (HP:0002591)2.01315213
74Increased muscle lipid content (HP:0009058)2.00804392
75Abnormal number of incisors (HP:0011064)2.00658402
76Optic disc pallor (HP:0000543)2.00541385
77Nasal polyposis (HP:0100582)1.99217506
78Acute necrotizing encephalopathy (HP:0006965)1.98057850
79Abnormality of T cells (HP:0002843)1.97877866
80Bilateral microphthalmos (HP:0007633)1.97769549
81Partial duplication of the phalanx of hand (HP:0009999)1.96768818
82Acute encephalopathy (HP:0006846)1.96763835
83Pendular nystagmus (HP:0012043)1.96705519
84Atrophy/Degeneration involving motor neurons (HP:0007373)1.96627049
85Testicular atrophy (HP:0000029)1.95934480
86Carpal bone hypoplasia (HP:0001498)1.95622983
87Abnormal mitochondria in muscle tissue (HP:0008316)1.92926922
88Sparse eyelashes (HP:0000653)1.92019441
89Abnormality of reticulocytes (HP:0004312)1.91247121
90Abnormality of iron homeostasis (HP:0011031)1.90359295
91Abnormal rod and cone electroretinograms (HP:0008323)1.89819309
92Aplasia/Hypoplasia of the thymus (HP:0010515)1.89646817
93IgM deficiency (HP:0002850)1.88554234
94Concave nail (HP:0001598)1.86186362
95Cheilitis (HP:0100825)1.85889702
96IgG deficiency (HP:0004315)1.84906941
97Colon cancer (HP:0003003)1.84638346
98Thoracic kyphosis (HP:0002942)1.84573063
99Hepatosplenomegaly (HP:0001433)1.83916408
100Hypochromic anemia (HP:0001931)1.82207554
101Renal Fanconi syndrome (HP:0001994)1.82204303
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81982612
103Abnormal protein N-linked glycosylation (HP:0012347)1.81982612
104Abnormal protein glycosylation (HP:0012346)1.81982612
105Abnormal glycosylation (HP:0012345)1.81982612
106Emotional lability (HP:0000712)1.80983177
107Rib fusion (HP:0000902)1.78916969
108Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78091096
109Dicarboxylic aciduria (HP:0003215)1.78091096
110Esotropia (HP:0000565)1.77907475
111Overlapping toe (HP:0001845)1.77379258
112Facial hemangioma (HP:0000329)1.77127049
113Recurrent viral infections (HP:0004429)1.76979564
114Paralysis (HP:0003470)1.76937611
115Thrombocytosis (HP:0001894)1.75758906
11611 pairs of ribs (HP:0000878)1.75748005
117Abnormality of renal resorption (HP:0011038)1.75644090
118Spastic paraparesis (HP:0002313)1.75169691
119Methylmalonic aciduria (HP:0012120)1.75139620
120Selective tooth agenesis (HP:0001592)1.74784906
121Leukodystrophy (HP:0002415)1.74475563
122Chronic obstructive pulmonary disease (HP:0006510)1.74469989
123Obstructive lung disease (HP:0006536)1.74469989
124Fused cervical vertebrae (HP:0002949)1.74246763
125Peritonitis (HP:0002586)1.74047156
126Rectovaginal fistula (HP:0000143)1.73230889
127Rectal fistula (HP:0100590)1.73230889
128Purpura (HP:0000979)1.73176506
129Recurrent skin infections (HP:0001581)1.72938746
130Stomatitis (HP:0010280)1.72791011
131Prolonged neonatal jaundice (HP:0006579)1.71656170
132Eczematoid dermatitis (HP:0000976)1.71401435
133Cutaneous photosensitivity (HP:0000992)1.71301970
134Abnormality of macrophages (HP:0004311)1.68794738
135Progressive microcephaly (HP:0000253)1.68108895
136Horseshoe kidney (HP:0000085)1.68075580
137Synostosis involving the elbow (HP:0003938)1.64517599
138Humeroradial synostosis (HP:0003041)1.64517599
139Lethargy (HP:0001254)1.62596061
140Septate vagina (HP:0001153)1.61678060
141Abnormality of the columella (HP:0009929)1.60431691
142Retinal dysplasia (HP:0007973)1.59279213
143Neutropenia (HP:0001875)1.59087768
144Abnormal delayed hypersensitivity skin test (HP:0002963)1.58879052
145Depressed nasal ridge (HP:0000457)1.58157582

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.54645193
2VRK24.29420318
3EIF2AK13.18430909
4TESK23.06046678
5ERN12.96163325
6BUB12.94325968
7PIM22.79684164
8WEE12.75160267
9GRK62.39626606
10TLK12.38620548
11MAP4K12.20025148
12STK162.12086249
13MOS2.03815213
14MAP3K112.02539006
15ZAK1.93598848
16STK101.81377031
17PASK1.72898620
18NUAK11.60434936
19VRK11.58397521
20BCKDK1.57230120
21CLK11.53024428
22KDR1.49264615
23DYRK31.43678392
24TAOK21.40535868
25CDK71.36975528
26TRIM281.35167447
27LIMK11.34675651
28RPS6KA41.32002244
29TTK1.31095085
30MATK1.30828390
31ARAF1.29343000
32NEK21.22689754
33ABL21.22633399
34LRRK21.15859962
35CSF1R1.14586587
36AURKA1.14510913
37MAP3K101.13899140
38CDK81.11750947
39PBK1.11131046
40BLK1.10883417
41MST41.09248361
42ADRBK21.08598142
43TRIB31.08334533
44TAF11.06264086
45CSK1.06103110
46PIM11.04715570
47EIF2AK31.03638437
48MAP3K31.02979768
49TBK11.02463676
50IKBKE1.02202533
51ZAP701.00943560
52MAP3K81.00368669
53FLT30.99731254
54RAF10.98749245
55PAK40.97741477
56PRKD20.97349265
57MAP2K70.97269619
58TSSK60.95531257
59CDK190.95392546
60GRK50.94604188
61SCYL20.94133196
62WNK40.93433802
63PLK10.91563448
64TYK20.90682858
65CDK120.90113811
66GRK10.89626958
67MAP2K30.89581270
68KIT0.88511270
69IKBKB0.88112248
70LMTK20.87297669
71CHEK20.86945835
72PAK10.86672061
73SMG10.82158994
74RPS6KB20.80477198
75PRKCQ0.79849141
76DYRK20.77038249
77TESK10.73294799
78FGR0.72907433
79DAPK30.72690077
80RPS6KA60.72386380
81CDC70.72082473
82DYRK1B0.71357921
83MAP3K90.68740691
84BRSK20.68181417
85IRAK40.67912711
86RPS6KL10.67078137
87RPS6KC10.67078137
88BRAF0.65533844
89CSNK1G30.65209707
90STK390.65071492
91MAPK150.62883887
92CDK40.62067663
93SYK0.61542115
94STK40.60486352
95SIK20.59725013
96RIPK40.58189495
97JAK30.57212497
98EPHA20.55986996
99LYN0.52931759
100HIPK20.52383483
101BTK0.52041570
102LCK0.51963516
103ADRBK10.51832953
104TGFBR20.50974558
105PRKCD0.50954290
106NEK10.49521391
107TEC0.49387418
108NME10.48975167
109TXK0.48969667
110PKN20.48807525
111RPS6KA50.46768333
112SIK10.46011853
113PAK20.45581403
114FES0.45303600
115SRPK10.44638830
116AURKB0.44547524
117GRK70.44377722
118CSNK2A20.44290150
119TYRO30.43710546
120IRAK30.42695115
121MAP3K60.41889936
122CDK140.41730020
123ACVR1B0.41257691
124PRKG20.41206152
125MARK30.41100082
126PRKCI0.40979966
127MAPKAPK20.39530934
128ATR0.38667539
129CSNK2A10.38598268
130ILK0.38361220
131MAP3K130.37988909
132BMX0.33561698
133PIK3CA0.31515743
134PTK60.31378787
135CSNK1G20.27404970
136MAP2K20.26118350
137MAP3K10.25415044
138CDK20.24368316
139TGFBR10.24220825
140CSNK1A10.23984081
141EPHB20.23248172

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.44798422
2DNA replication_Homo sapiens_hsa030303.90268465
3Proteasome_Homo sapiens_hsa030503.26244917
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.15958220
5Sulfur relay system_Homo sapiens_hsa041223.09265828
6RNA polymerase_Homo sapiens_hsa030202.90633335
7Mismatch repair_Homo sapiens_hsa034302.51210321
8Spliceosome_Homo sapiens_hsa030402.47056556
9Base excision repair_Homo sapiens_hsa034102.27960304
10Pyrimidine metabolism_Homo sapiens_hsa002402.27741958
11One carbon pool by folate_Homo sapiens_hsa006702.25701472
12Folate biosynthesis_Homo sapiens_hsa007902.19339220
13Nucleotide excision repair_Homo sapiens_hsa034202.07029561
14Vitamin B6 metabolism_Homo sapiens_hsa007501.97763747
15Homologous recombination_Homo sapiens_hsa034401.95274535
16RNA transport_Homo sapiens_hsa030131.82419839
17Oxidative phosphorylation_Homo sapiens_hsa001901.75281747
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74385810
19Protein export_Homo sapiens_hsa030601.54893123
20Parkinsons disease_Homo sapiens_hsa050121.53888695
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48317119
22Pentose phosphate pathway_Homo sapiens_hsa000301.34136021
23Primary immunodeficiency_Homo sapiens_hsa053401.33679087
24Antigen processing and presentation_Homo sapiens_hsa046121.33077216
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32362703
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.26604029
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26266857
28Cell cycle_Homo sapiens_hsa041101.25499121
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21486327
30Cardiac muscle contraction_Homo sapiens_hsa042601.19331095
31Basal transcription factors_Homo sapiens_hsa030221.18996298
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18801685
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17452294
34Huntingtons disease_Homo sapiens_hsa050161.17240619
35p53 signaling pathway_Homo sapiens_hsa041151.15622972
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09189848
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04300121
38Selenocompound metabolism_Homo sapiens_hsa004500.99925342
39Epstein-Barr virus infection_Homo sapiens_hsa051690.97504403
40Alzheimers disease_Homo sapiens_hsa050100.93792386
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93216739
42Fanconi anemia pathway_Homo sapiens_hsa034600.90516492
43Shigellosis_Homo sapiens_hsa051310.90094901
44Biosynthesis of amino acids_Homo sapiens_hsa012300.90084106
45RNA degradation_Homo sapiens_hsa030180.89641437
46Herpes simplex infection_Homo sapiens_hsa051680.88817678
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.88067072
48Collecting duct acid secretion_Homo sapiens_hsa049660.87995955
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86739128
50N-Glycan biosynthesis_Homo sapiens_hsa005100.86641293
51Purine metabolism_Homo sapiens_hsa002300.86350346
52Legionellosis_Homo sapiens_hsa051340.85187126
53Regulation of autophagy_Homo sapiens_hsa041400.83467459
54Steroid biosynthesis_Homo sapiens_hsa001000.83428210
55Glutathione metabolism_Homo sapiens_hsa004800.82107496
56Sulfur metabolism_Homo sapiens_hsa009200.78320694
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77369530
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77247243
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76212964
60Leishmaniasis_Homo sapiens_hsa051400.73630169
61Carbon metabolism_Homo sapiens_hsa012000.71317159
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.70396772
63Apoptosis_Homo sapiens_hsa042100.69810924
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.68257493
65Measles_Homo sapiens_hsa051620.66305884
66Systemic lupus erythematosus_Homo sapiens_hsa053220.65017619
67Alcoholism_Homo sapiens_hsa050340.64625982
68Acute myeloid leukemia_Homo sapiens_hsa052210.64263843
69Autoimmune thyroid disease_Homo sapiens_hsa053200.64091118
70B cell receptor signaling pathway_Homo sapiens_hsa046620.63522971
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62638748
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59564113
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59389873
74Thyroid cancer_Homo sapiens_hsa052160.58082488
75Viral carcinogenesis_Homo sapiens_hsa052030.53442038
76Metabolic pathways_Homo sapiens_hsa011000.52856863
77Rheumatoid arthritis_Homo sapiens_hsa053230.51664922
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51599846
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48737166
80Other glycan degradation_Homo sapiens_hsa005110.48665582
81Arginine and proline metabolism_Homo sapiens_hsa003300.45806440
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45636890
83Hematopoietic cell lineage_Homo sapiens_hsa046400.45157013
84Allograft rejection_Homo sapiens_hsa053300.42924567
85Fructose and mannose metabolism_Homo sapiens_hsa000510.42786641
86Arachidonic acid metabolism_Homo sapiens_hsa005900.42368345
87Malaria_Homo sapiens_hsa051440.41350641
88Fat digestion and absorption_Homo sapiens_hsa049750.40593785
89T cell receptor signaling pathway_Homo sapiens_hsa046600.40468636
90VEGF signaling pathway_Homo sapiens_hsa043700.40079609
91Graft-versus-host disease_Homo sapiens_hsa053320.39855001
92Linoleic acid metabolism_Homo sapiens_hsa005910.39783851
93Bladder cancer_Homo sapiens_hsa052190.39539525
94Non-homologous end-joining_Homo sapiens_hsa034500.38205509
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37757114
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37712446
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36560999
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36349220
99mRNA surveillance pathway_Homo sapiens_hsa030150.36138425
100Ether lipid metabolism_Homo sapiens_hsa005650.36137010
101Asthma_Homo sapiens_hsa053100.35722724
102Hepatitis B_Homo sapiens_hsa051610.33087598
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31494894
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.31493893
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30080515
106Fatty acid elongation_Homo sapiens_hsa000620.29795131
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29739187
108Tuberculosis_Homo sapiens_hsa051520.29617245
109Butanoate metabolism_Homo sapiens_hsa006500.28667403
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28147248
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28131820
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27646216
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.27540346
114Lysosome_Homo sapiens_hsa041420.26567608
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26504458
116Galactose metabolism_Homo sapiens_hsa000520.26342892
117HTLV-I infection_Homo sapiens_hsa051660.25619982
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24808775
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24664151
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23900262
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21632923
122Tyrosine metabolism_Homo sapiens_hsa003500.21443464
123Type I diabetes mellitus_Homo sapiens_hsa049400.20614067
124Influenza A_Homo sapiens_hsa051640.19634068
125Vitamin digestion and absorption_Homo sapiens_hsa049770.19452373
126Peroxisome_Homo sapiens_hsa041460.18886015
127Phototransduction_Homo sapiens_hsa047440.18555820
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18251299
129Viral myocarditis_Homo sapiens_hsa054160.18161323
130Vibrio cholerae infection_Homo sapiens_hsa051100.17964088
131Basal cell carcinoma_Homo sapiens_hsa052170.14907399

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »