BLOC1S5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of BLOC-1 (biogenesis of lysosome-related organelles complex 1). Components of this complex are involved in the biogenesis of organelles such as melanosomes and platelet-dense granules. A mouse model for Hermansky-Pudlak Syndrome is mutated in the murine version of this gene. Alternative splicing results in multiple transcript variants. Read-through transcription exists between this gene and the upstream EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1) gene, as well as with the downstream TXNDC5 (thioredoxin domain containing 5) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.21092889
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.21092889
3L-phenylalanine metabolic process (GO:0006558)6.18974366
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.18974366
5aromatic amino acid family catabolic process (GO:0009074)5.38188792
6glyoxylate metabolic process (GO:0046487)5.14976247
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.13534004
8cysteine metabolic process (GO:0006534)5.05231008
9alpha-linolenic acid metabolic process (GO:0036109)4.93927126
10lysine catabolic process (GO:0006554)4.88600519
11lysine metabolic process (GO:0006553)4.88600519
12bile acid biosynthetic process (GO:0006699)4.83114139
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.76840207
14negative regulation of fibrinolysis (GO:0051918)4.58885189
15indole-containing compound catabolic process (GO:0042436)4.57736611
16indolalkylamine catabolic process (GO:0046218)4.57736611
17tryptophan catabolic process (GO:0006569)4.57736611
18kynurenine metabolic process (GO:0070189)4.56935511
19amino-acid betaine metabolic process (GO:0006577)4.48311324
20protein neddylation (GO:0045116)4.46528092
21sulfur amino acid catabolic process (GO:0000098)4.41162977
22high-density lipoprotein particle remodeling (GO:0034375)4.40546316
23protein carboxylation (GO:0018214)4.34305005
24peptidyl-glutamic acid carboxylation (GO:0017187)4.34305005
25serine family amino acid catabolic process (GO:0009071)4.31286853
26cellular ketone body metabolic process (GO:0046950)4.31211527
27regulation of fibrinolysis (GO:0051917)4.30177702
28tryptophan metabolic process (GO:0006568)4.29239240
29proteasome assembly (GO:0043248)4.28185932
30urea cycle (GO:0000050)4.21822657
31urea metabolic process (GO:0019627)4.21822657
32glycine metabolic process (GO:0006544)4.21179477
33chromatin remodeling at centromere (GO:0031055)4.16870976
34DNA double-strand break processing (GO:0000729)4.16061371
35CENP-A containing nucleosome assembly (GO:0034080)4.10534765
36valine metabolic process (GO:0006573)4.09438835
37aromatic amino acid family metabolic process (GO:0009072)4.09194099
38regulation of protein activation cascade (GO:2000257)4.05730525
39cofactor catabolic process (GO:0051187)4.03131937
40alpha-amino acid catabolic process (GO:1901606)4.00907411
41bile acid metabolic process (GO:0008206)3.96624402
42complement activation, alternative pathway (GO:0006957)3.95784786
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.93054458
44serine family amino acid metabolic process (GO:0009069)3.90435490
45nitrogen cycle metabolic process (GO:0071941)3.88923751
46blood coagulation, intrinsic pathway (GO:0007597)3.87345748
47protein-lipid complex remodeling (GO:0034368)3.84916644
48macromolecular complex remodeling (GO:0034367)3.84916644
49plasma lipoprotein particle remodeling (GO:0034369)3.84916644
50tyrosine metabolic process (GO:0006570)3.83932789
51regulation of cholesterol esterification (GO:0010872)3.82016125
52reverse cholesterol transport (GO:0043691)3.81750956
53serine family amino acid biosynthetic process (GO:0009070)3.80395387
54regulation of complement activation (GO:0030449)3.79904798
55fatty acid beta-oxidation (GO:0006635)3.76378769
56mitochondrial respiratory chain complex I assembly (GO:0032981)3.75643364
57NADH dehydrogenase complex assembly (GO:0010257)3.75643364
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.75643364
59regulation of triglyceride catabolic process (GO:0010896)3.75062420
60cellular amino acid catabolic process (GO:0009063)3.74984493
61ketone body metabolic process (GO:1902224)3.73873062
62aldehyde catabolic process (GO:0046185)3.73355715
63coenzyme catabolic process (GO:0009109)3.71778464
64arginine metabolic process (GO:0006525)3.71481410
65triglyceride homeostasis (GO:0070328)3.70642942
66acylglycerol homeostasis (GO:0055090)3.70642942
67regulation of cilium movement (GO:0003352)3.68591993
68homocysteine metabolic process (GO:0050667)3.66266641
69protein complex biogenesis (GO:0070271)3.66257099
70fatty acid catabolic process (GO:0009062)3.63108144
71fatty acid oxidation (GO:0019395)3.62876481
72carnitine metabolic process (GO:0009437)3.60782933
73imidazole-containing compound metabolic process (GO:0052803)3.60331873
74energy coupled proton transport, down electrochemical gradient (GO:0015985)3.60315274
75ATP synthesis coupled proton transport (GO:0015986)3.60315274
76mitochondrial respiratory chain complex assembly (GO:0033108)3.60126628
77plasma lipoprotein particle clearance (GO:0034381)3.59821824
78aspartate family amino acid catabolic process (GO:0009068)3.58806522
79lipid oxidation (GO:0034440)3.57760175
80replication fork processing (GO:0031297)3.57287605
812-oxoglutarate metabolic process (GO:0006103)3.55799823
82carboxylic acid catabolic process (GO:0046395)3.53128440
83organic acid catabolic process (GO:0016054)3.53128440
84monocarboxylic acid catabolic process (GO:0072329)3.51364302
85telomere maintenance via semi-conservative replication (GO:0032201)3.50463828
86heme transport (GO:0015886)3.45890006
87acetyl-CoA metabolic process (GO:0006084)3.44678522
88histone exchange (GO:0043486)3.44288574
89deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.43283906
90phospholipid efflux (GO:0033700)3.40909566
91ethanol oxidation (GO:0006069)3.40710923
92somatic diversification of immune receptors via somatic mutation (GO:0002566)3.39820157
93somatic hypermutation of immunoglobulin genes (GO:0016446)3.39820157
94flavonoid metabolic process (GO:0009812)3.39489028
95DNA catabolic process, exonucleolytic (GO:0000738)3.39377685
96nucleotide-excision repair, DNA gap filling (GO:0006297)3.39104094
97bile acid and bile salt transport (GO:0015721)3.38989698
98nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38907673
99branched-chain amino acid catabolic process (GO:0009083)3.38543300
100short-chain fatty acid metabolic process (GO:0046459)3.37250862
101establishment of protein localization to mitochondrial membrane (GO:0090151)3.35731322
102RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.34654607
103tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.34654607
104exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33865094
105centriole replication (GO:0007099)3.33689225
106negative regulation of sterol transport (GO:0032372)3.32109473
107negative regulation of cholesterol transport (GO:0032375)3.32109473
108cellular biogenic amine catabolic process (GO:0042402)3.31517127
109amine catabolic process (GO:0009310)3.31517127
110cellular modified amino acid catabolic process (GO:0042219)3.30563837
111drug transmembrane transport (GO:0006855)3.29984670
112low-density lipoprotein particle remodeling (GO:0034374)3.29872391
113DNA ligation (GO:0006266)3.29868266
114mismatch repair (GO:0006298)3.29311601
115glutamate metabolic process (GO:0006536)3.27479484
116attachment of spindle microtubules to kinetochore (GO:0008608)3.26920137
117cholesterol efflux (GO:0033344)3.26191863
118very long-chain fatty acid metabolic process (GO:0000038)3.23054201
119histone mRNA metabolic process (GO:0008334)3.19976311
120negative regulation of DNA-dependent DNA replication (GO:2000104)3.18685050
121kinetochore assembly (GO:0051382)3.16902476
122benzene-containing compound metabolic process (GO:0042537)3.16845560
123mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.16775445
124branched-chain amino acid metabolic process (GO:0009081)3.16371511
125ubiquinone biosynthetic process (GO:0006744)3.16200189
126platelet dense granule organization (GO:0060155)3.16167568
127preassembly of GPI anchor in ER membrane (GO:0016254)3.15210421
128DNA strand elongation involved in DNA replication (GO:0006271)3.15069994
129indolalkylamine metabolic process (GO:0006586)3.15023165
130negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14807927
131oxaloacetate metabolic process (GO:0006107)3.14375059
132synapsis (GO:0007129)3.14012911
133NAD biosynthetic process (GO:0009435)3.13762473
134pyridine nucleotide biosynthetic process (GO:0019363)3.13444168
135nicotinamide nucleotide biosynthetic process (GO:0019359)3.13444168
136cullin deneddylation (GO:0010388)3.12454749
137telomere maintenance via recombination (GO:0000722)3.12375921
138purine nucleobase biosynthetic process (GO:0009113)3.11262793
139microtubule depolymerization (GO:0007019)3.10566954
140regulation of cholesterol metabolic process (GO:0090181)3.10412246
141recombinational repair (GO:0000725)3.09188761
142cholesterol homeostasis (GO:0042632)3.08590896
143fructose metabolic process (GO:0006000)3.07114463
144kinetochore organization (GO:0051383)3.05714811
145DNA replication-independent nucleosome organization (GO:0034724)3.05683995
146DNA replication-independent nucleosome assembly (GO:0006336)3.05683995
147response to mercury ion (GO:0046689)3.05512315
148plasma lipoprotein particle assembly (GO:0034377)3.03856929
149cellular glucuronidation (GO:0052695)3.03722194
150regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03500572
151mannosylation (GO:0097502)3.03268351
152ubiquinone metabolic process (GO:0006743)3.03033802
153histone H2A acetylation (GO:0043968)3.02627070
154mitotic recombination (GO:0006312)3.02469504
155respiratory chain complex IV assembly (GO:0008535)3.02164277
156double-strand break repair via homologous recombination (GO:0000724)3.01817702
157water-soluble vitamin biosynthetic process (GO:0042364)3.01467609
158respiratory electron transport chain (GO:0022904)3.00214526
159protein deneddylation (GO:0000338)2.99405053
160maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99350538
161resolution of meiotic recombination intermediates (GO:0000712)2.98866460
162electron transport chain (GO:0022900)2.98588092
163translesion synthesis (GO:0019985)2.94226135
164DNA strand elongation (GO:0022616)2.93718538
165positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.93450458
166postreplication repair (GO:0006301)2.93286167
167maturation of 5.8S rRNA (GO:0000460)2.91225023
168DNA deamination (GO:0045006)2.90602501
169meiotic chromosome segregation (GO:0045132)2.90414636
170adenosine metabolic process (GO:0046085)2.85891008
171DNA replication checkpoint (GO:0000076)2.85820219
172DNA-dependent DNA replication (GO:0006261)2.84769453
173regulation of acyl-CoA biosynthetic process (GO:0050812)2.81124632
174pseudouridine synthesis (GO:0001522)2.80945371
175pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.80892923
176nucleobase biosynthetic process (GO:0046112)2.80843904
177organelle disassembly (GO:1903008)2.80594221
178protein prenylation (GO:0018342)2.79876698
179prenylation (GO:0097354)2.79876698
180protein-cofactor linkage (GO:0018065)2.79787718
181negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.78357916
182negative regulation of ligase activity (GO:0051352)2.78357916
183telomere maintenance via telomere lengthening (GO:0010833)2.78003641
184mitochondrial RNA metabolic process (GO:0000959)2.77488647
185pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.77422614
186transcription elongation from RNA polymerase III promoter (GO:0006385)2.77065708
187termination of RNA polymerase III transcription (GO:0006386)2.77065708
188anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.76401469
189cytochrome complex assembly (GO:0017004)2.75299577
190regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.75022120
191purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.74971936
192signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.74815181
193signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74815181
194signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.74815181
195DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73750911
196GPI anchor metabolic process (GO:0006505)2.72512339
197mitotic G2/M transition checkpoint (GO:0044818)2.72106461
198regulation of mitochondrial translation (GO:0070129)2.72049749
199RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.71790146
200isotype switching (GO:0045190)2.70358432

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.97211869
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.09123792
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.86258119
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.09674726
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.76395067
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.41669442
7LXR_22158963_ChIP-Seq_LIVER_Mouse4.18059978
8E2F7_22180533_ChIP-Seq_HELA_Human4.12298690
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.61140325
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.46085982
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22456654
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.18995081
13ELK1_19687146_ChIP-ChIP_HELA_Human2.92845405
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84945316
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.62758451
16ZNF274_21170338_ChIP-Seq_K562_Hela2.51574116
17EWS_26573619_Chip-Seq_HEK293_Human2.12334396
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.12100464
19VDR_22108803_ChIP-Seq_LS180_Human2.11656157
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.09043855
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.07515104
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06987713
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03548931
24IGF1R_20145208_ChIP-Seq_DFB_Human1.99987243
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99935664
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99055082
27MYC_18940864_ChIP-ChIP_HL60_Human1.96230106
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.93094959
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.88796644
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87452706
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.86576740
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86573657
33FUS_26573619_Chip-Seq_HEK293_Human1.84623203
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.80881026
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76202712
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.74074772
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72348452
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71422496
39TAF15_26573619_Chip-Seq_HEK293_Human1.69610564
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.69535160
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.66639569
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66302090
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.60700271
44TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.59231155
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.51973335
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49432758
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.43662920
48IRF1_19129219_ChIP-ChIP_H3396_Human1.43397964
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39226645
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37546699
51DCP1A_22483619_ChIP-Seq_HELA_Human1.33879052
52GATA1_22025678_ChIP-Seq_K562_Human1.33046884
53CLOCK_20551151_ChIP-Seq_293T_Human1.30359426
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29108732
55TTF2_22483619_ChIP-Seq_HELA_Human1.28758225
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27734189
57P300_19829295_ChIP-Seq_ESCs_Human1.26791881
58ZNF263_19887448_ChIP-Seq_K562_Human1.24498870
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23865000
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23362373
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22339432
62ER_23166858_ChIP-Seq_MCF-7_Human1.20934882
63SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.20686672
64TP53_22573176_ChIP-Seq_HFKS_Human1.19830438
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18392126
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16633350
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16403697
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15181808
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14998635
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14611507
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14378723
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12366998
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.11714651
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11637618
75GBX2_23144817_ChIP-Seq_PC3_Human1.11605261
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10993043
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.08680019
78FOXP3_21729870_ChIP-Seq_TREG_Human1.06725513
79KDM5A_27292631_Chip-Seq_BREAST_Human1.06633224
80MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06519666
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06409029
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06136401
83XRN2_22483619_ChIP-Seq_HELA_Human1.05619709
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05108955
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05012651
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04216037
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03901890
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03878742
89GABP_19822575_ChIP-Seq_HepG2_Human1.03367724
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03318527
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03301843
92CIITA_25753668_ChIP-Seq_RAJI_Human1.02620791
93RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02458955
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02339457
95NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02163526
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01170486
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99485858
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.99158380
99SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98860354
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98738209
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98386881
102VDR_23849224_ChIP-Seq_CD4+_Human0.97141863
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96974415
104ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96696108
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96397834
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95965714
107CBP_20019798_ChIP-Seq_JUKART_Human0.95121168
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95121168
109FOXA1_25329375_ChIP-Seq_VCAP_Human0.95109166
110FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95109166
111HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94715864
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93518573
113HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93339363
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91305194
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90926481
116POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89894357
117CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89587918
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89479349
119HTT_18923047_ChIP-ChIP_STHdh_Human0.89128935
120MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88980149
121TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88712804
122AR_20517297_ChIP-Seq_VCAP_Human0.88496169
123SOX2_19829295_ChIP-Seq_ESCs_Human0.87945436
124NANOG_19829295_ChIP-Seq_ESCs_Human0.87945436
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87748088
126POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87715526
127YY1_21170310_ChIP-Seq_MESCs_Mouse0.87324735
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86298396
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85709687
130ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85698759
131PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85552988
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85067111
133GATA1_19941827_ChIP-Seq_MEL_Mouse0.84974453
134TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84956162
135POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84177083
136BCL6_27268052_Chip-Seq_Bcells_Human0.83996502
137CTCF_18555785_ChIP-Seq_MESCs_Mouse0.82077301
138SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81416769
139HNF4A_19822575_ChIP-Seq_HepG2_Human0.80437786
140LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.79847496
141GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78947943
142IRF8_22096565_ChIP-ChIP_GC-B_Human0.78107731
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77691854
144STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.77665869
145LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73767846
146MYC_19079543_ChIP-ChIP_MESCs_Mouse0.73644355
147HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73506827
148NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73498551
149RARA_24833708_ChIP-Seq_LIVER_Mouse0.72179936
150CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.71831333
151IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.71138026
152TBX5_21415370_ChIP-Seq_HL-1_Mouse0.70836757
153TET1_21451524_ChIP-Seq_MESCs_Mouse0.68307408
154RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68062134
155YY1_22570637_ChIP-Seq_MALME-3M_Human0.67613922
156RARB_24833708_ChIP-Seq_LIVER_Mouse0.67568103
157CTCF_26484167_Chip-Seq_Bcells_Mouse0.67500849
158BCOR_27268052_Chip-Seq_Bcells_Human0.66165789
159OCT4_18692474_ChIP-Seq_MEFs_Mouse0.66126873
160GATA2_22383799_ChIP-Seq_G1ME_Mouse0.65793724

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.38977501
2MP0005360_urolithiasis6.60396331
3MP0005085_abnormal_gallbladder_physiolo5.30000075
4MP0005365_abnormal_bile_salt5.17699858
5MP0003806_abnormal_nucleotide_metabolis5.04977068
6MP0008875_abnormal_xenobiotic_pharmacok4.16606261
7MP0008058_abnormal_DNA_repair3.98109667
8MP0009840_abnormal_foam_cell3.73255652
9MP0010094_abnormal_chromosome_stability3.58148505
10MP0010329_abnormal_lipoprotein_level3.21552916
11MP0000372_irregular_coat_pigmentation3.09808224
12MP0005083_abnormal_biliary_tract3.05532811
13MP0003252_abnormal_bile_duct3.00668620
14MP0006292_abnormal_olfactory_placode2.80790769
15MP0003191_abnormal_cellular_cholesterol2.65413070
16MP0005332_abnormal_amino_acid2.63219823
17MP0003195_calcinosis2.62850933
18MP0008877_abnormal_DNA_methylation2.56873657
19MP0003656_abnormal_erythrocyte_physiolo2.56538205
20MP0008057_abnormal_DNA_replication2.49325529
21MP0004957_abnormal_blastocyst_morpholog2.43706513
22MP0003111_abnormal_nucleus_morphology2.40169785
23MP0002102_abnormal_ear_morphology2.28438760
24MP0003077_abnormal_cell_cycle2.23594487
25MP0003693_abnormal_embryo_hatching2.16442644
26MP0004147_increased_porphyrin_level2.07442425
27MP0005319_abnormal_enzyme/_coenzyme2.07110711
28MP0001666_abnormal_nutrient_absorption2.03743923
29MP0000609_abnormal_liver_physiology2.03586696
30MP0001764_abnormal_homeostasis2.02261700
31MP0002118_abnormal_lipid_homeostasis2.01732876
32MP0006036_abnormal_mitochondrial_physio1.99401280
33MP0008932_abnormal_embryonic_tissue1.97185880
34MP0008007_abnormal_cellular_replicative1.90865575
35MP0003186_abnormal_redox_activity1.86745169
36MP0006072_abnormal_retinal_apoptosis1.85120517
37MP0005584_abnormal_enzyme/coenzyme_acti1.78597645
38MP0004019_abnormal_vitamin_homeostasis1.72050251
39MP0003136_yellow_coat_color1.66756633
40MP0008789_abnormal_olfactory_epithelium1.60870697
41MP0006035_abnormal_mitochondrial_morpho1.56567308
42MP0002938_white_spotting1.55375687
43MP0005551_abnormal_eye_electrophysiolog1.55094299
44MP0003868_abnormal_feces_composition1.51061727
45MP0001293_anophthalmia1.50964480
46MP0003890_abnormal_embryonic-extraembry1.48181840
47MP0003567_abnormal_fetal_cardiomyocyte1.45899069
48MP0002638_abnormal_pupillary_reflex1.45753561
49MP0005253_abnormal_eye_physiology1.44392383
50MP0002095_abnormal_skin_pigmentation1.43291325
51MP0005410_abnormal_fertilization1.39950889
52MP0009643_abnormal_urine_homeostasis1.38636442
53MP0009379_abnormal_foot_pigmentation1.38039443
54MP0001529_abnormal_vocalization1.37970529
55MP0003786_premature_aging1.36466316
56MP0004130_abnormal_muscle_cell1.36080384
57MP0001929_abnormal_gametogenesis1.34397550
58MP0005636_abnormal_mineral_homeostasis1.30995582
59MP0003011_delayed_dark_adaptation1.30828794
60MP0005367_renal/urinary_system_phenotyp1.30575084
61MP0000516_abnormal_urinary_system1.30575084
62MP0010368_abnormal_lymphatic_system1.30413804
63MP0000598_abnormal_liver_morphology1.28975234
64MP0001324_abnormal_eye_pigmentation1.26866475
65MP0000015_abnormal_ear_pigmentation1.23136676
66MP0009697_abnormal_copulation1.22281554
67MP0000569_abnormal_digit_pigmentation1.22082347
68MP0002876_abnormal_thyroid_physiology1.21896656
69MP0002138_abnormal_hepatobiliary_system1.21511636
70MP0003787_abnormal_imprinting1.21199434
71MP0005451_abnormal_body_composition1.19095287
72MP0009764_decreased_sensitivity_to1.17771071
73MP0005394_taste/olfaction_phenotype1.15073765
74MP0005499_abnormal_olfactory_system1.15073765
75MP0005670_abnormal_white_adipose1.13741948
76MP0008469_abnormal_protein_level1.13236057
77MP0002210_abnormal_sex_determination1.13081635
78MP0005389_reproductive_system_phenotype1.11835642
79MP0000631_abnormal_neuroendocrine_gland1.07902184
80MP0005174_abnormal_tail_pigmentation1.06198370
81MP0003121_genomic_imprinting1.05849736
82MP0002837_dystrophic_cardiac_calcinosis1.05837192
83MP0004142_abnormal_muscle_tone1.05600854
84MP0009763_increased_sensitivity_to1.04019197
85MP0005266_abnormal_metabolism1.03736411
86MP0001984_abnormal_olfaction1.03545443
87MP0001919_abnormal_reproductive_system1.03441454
88MP0001145_abnormal_male_reproductive1.01538003
89MP0000653_abnormal_sex_gland1.00245851
90MP0003698_abnormal_male_reproductive0.99576668
91MP0003724_increased_susceptibility_to0.99305158
92MP0005376_homeostasis/metabolism_phenot0.97039969
93MP0006054_spinal_hemorrhage0.92606866
94MP0003705_abnormal_hypodermis_morpholog0.91912390
95MP0009642_abnormal_blood_homeostasis0.90760269
96MP0005645_abnormal_hypothalamus_physiol0.90561606
97MP0005535_abnormal_body_temperature0.90110628
98MP0002019_abnormal_tumor_incidence0.89259820
99MP0001119_abnormal_female_reproductive0.89062121
100MP0000604_amyloidosis0.87941191
101MP0002160_abnormal_reproductive_system0.87263288
102MP0000427_abnormal_hair_cycle0.86135307
103MP0002332_abnormal_exercise_endurance0.83476208
104MP0002078_abnormal_glucose_homeostasis0.81736787
105MP0005646_abnormal_pituitary_gland0.81662515
106MP0002234_abnormal_pharynx_morphology0.81331474
107MP0005647_abnormal_sex_gland0.80099427
108MP0005058_abnormal_lysosome_morphology0.80032043
109MP0003221_abnormal_cardiomyocyte_apopto0.79317422
110MP0005464_abnormal_platelet_physiology0.78133545
111MP0002971_abnormal_brown_adipose0.77490403
112MP0001756_abnormal_urination0.77180181
113MP0000313_abnormal_cell_death0.75904144
114MP0001905_abnormal_dopamine_level0.75821633
115MP0000371_diluted_coat_color0.75262761
116MP0001697_abnormal_embryo_size0.74307259
117MP0008995_early_reproductive_senescence0.72793902
118MP0005195_abnormal_posterior_eye0.72583905
119MP0003937_abnormal_limbs/digits/tail_de0.70298486
120MP0005220_abnormal_exocrine_pancreas0.70015588
121MP0006276_abnormal_autonomic_nervous0.69869611
122MP0005084_abnormal_gallbladder_morpholo0.69323572
123MP0004782_abnormal_surfactant_physiolog0.68786006
124MP0005395_other_phenotype0.68595140
125MP0002751_abnormal_autonomic_nervous0.68088224
126MP0005391_vision/eye_phenotype0.67984647
127MP0001835_abnormal_antigen_presentation0.67786005
128MP0002277_abnormal_respiratory_mucosa0.67532590
129MP0003137_abnormal_impulse_conducting0.67452447
130MP0002653_abnormal_ependyma_morphology0.67352792
131MP0001286_abnormal_eye_development0.67276802
132MP0000647_abnormal_sebaceous_gland0.66633984
133MP0000358_abnormal_cell_content/0.65854928
134MP0002282_abnormal_trachea_morphology0.65480089
135MP0005408_hypopigmentation0.64646552
136MP0005334_abnormal_fat_pad0.64618228
137MP0009765_abnormal_xenobiotic_induced0.64479442
138MP0003718_maternal_effect0.61409574
139MP0002090_abnormal_vision0.58627830
140MP0003646_muscle_fatigue0.58606560
141MP0002269_muscular_atrophy0.58546727
142MP0005075_abnormal_melanosome_morpholog0.58176160
143MP0003436_decreased_susceptibility_to0.57718313
144MP0008260_abnormal_autophagy0.56574978
145MP0000230_abnormal_systemic_arterial0.55658000
146MP0003172_abnormal_lysosome_physiology0.55112466
147MP0002132_abnormal_respiratory_system0.55015403
148MP0008873_increased_physiological_sensi0.54820715
149MP0003329_amyloid_beta_deposits0.54693246
150MP0001661_extended_life_span0.54337069
151MP0002136_abnormal_kidney_physiology0.53448370
152MP0001853_heart_inflammation0.53425100
153MP0004043_abnormal_pH_regulation0.52160110
154MP0001545_abnormal_hematopoietic_system0.49385926
155MP0005397_hematopoietic_system_phenotyp0.49385926
156MP0005330_cardiomyopathy0.48116022
157MP0005448_abnormal_energy_balance0.47745170
158MP0000249_abnormal_blood_vessel0.47286298
159MP0002970_abnormal_white_adipose0.46588500
160MP0003638_abnormal_response/metabolism_0.46568607
161MP0003690_abnormal_glial_cell0.46244732
162MP0004215_abnormal_myocardial_fiber0.45429460
163MP0008872_abnormal_physiological_respon0.45122199
164MP0009785_altered_susceptibility_to0.45051387
165MP0001845_abnormal_inflammatory_respons0.44238966
166MP0008775_abnormal_heart_ventricle0.44208141
167MP0004036_abnormal_muscle_relaxation0.42921730
168MP0000749_muscle_degeneration0.42113493
169MP0005248_abnormal_Harderian_gland0.41413400
170MP0004084_abnormal_cardiac_muscle0.41288029
171MP0005167_abnormal_blood-brain_barrier0.39646207
172MP0001544_abnormal_cardiovascular_syste0.39555683

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.11787144
2Deep venous thrombosis (HP:0002625)5.50883413
3Intrahepatic cholestasis (HP:0001406)5.45124249
4Hypobetalipoproteinemia (HP:0003563)5.09346343
5Xanthomatosis (HP:0000991)4.91071986
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.88259614
7Hyperlipoproteinemia (HP:0010980)4.83482922
8Prolonged partial thromboplastin time (HP:0003645)4.82668972
9Hyperammonemia (HP:0001987)4.37586503
10Hypoglycemic coma (HP:0001325)3.99339987
11Abnormality of fatty-acid metabolism (HP:0004359)3.91945484
12Hypolipoproteinemia (HP:0010981)3.91416157
13Hyperglycinemia (HP:0002154)3.88279992
14Ketosis (HP:0001946)3.78103173
15Hyperglycinuria (HP:0003108)3.62848046
16Abnormality of serine family amino acid metabolism (HP:0010894)3.62026727
17Abnormality of glycine metabolism (HP:0010895)3.62026727
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.60818207
19Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.58637671
20Complement deficiency (HP:0004431)3.42347608
21Hypoalphalipoproteinemia (HP:0003233)3.41692922
22Joint hemorrhage (HP:0005261)3.39712243
23Hyperbilirubinemia (HP:0002904)3.39361443
24Abnormality of the heme biosynthetic pathway (HP:0010472)3.35888149
253-Methylglutaconic aciduria (HP:0003535)3.35837206
26Abnormality of methionine metabolism (HP:0010901)3.31768573
27Abnormality of the intrinsic pathway (HP:0010989)3.28512481
28Pancreatic cysts (HP:0001737)3.27603159
29Increased CSF lactate (HP:0002490)3.26697608
30Progressive macrocephaly (HP:0004481)3.26209865
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.25648174
32Dicarboxylic aciduria (HP:0003215)3.24327042
33Abnormality of dicarboxylic acid metabolism (HP:0010995)3.24327042
34Abnormality of the common coagulation pathway (HP:0010990)3.23323314
35Hypercholesterolemia (HP:0003124)3.19939906
36Cerebral edema (HP:0002181)3.19325745
37Abnormality of sulfur amino acid metabolism (HP:0004339)3.17684898
38Abnormality of alanine metabolism (HP:0010916)3.09937014
39Hyperalaninemia (HP:0003348)3.09937014
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.09937014
41Abnormality of serum amino acid levels (HP:0003112)3.09930874
42Abnormality of glutamine family amino acid metabolism (HP:0010902)3.09612028
43Generalized aminoaciduria (HP:0002909)3.05541630
44Hepatic necrosis (HP:0002605)3.02597924
45Medial flaring of the eyebrow (HP:0010747)2.94042453
46Lethargy (HP:0001254)2.91126717
47Abnormality of chromosome stability (HP:0003220)2.90694300
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.89356726
49Pancreatic fibrosis (HP:0100732)2.87941042
50Epidermoid cyst (HP:0200040)2.87478866
51Meckel diverticulum (HP:0002245)2.87465537
52Fat malabsorption (HP:0002630)2.86118577
53True hermaphroditism (HP:0010459)2.83657359
54Brushfield spots (HP:0001088)2.83130140
55Cholecystitis (HP:0001082)2.82641580
56Abnormal gallbladder physiology (HP:0012438)2.82641580
57Molar tooth sign on MRI (HP:0002419)2.81417200
58Abnormality of midbrain morphology (HP:0002418)2.81417200
59Abnormality of the ileum (HP:0001549)2.75635226
60Metabolic acidosis (HP:0001942)2.74857486
61Ketoacidosis (HP:0001993)2.70411701
62Gout (HP:0001997)2.69196160
63Colon cancer (HP:0003003)2.65774273
64Volvulus (HP:0002580)2.65422677
65Increased hepatocellular lipid droplets (HP:0006565)2.62148187
66Cholelithiasis (HP:0001081)2.60314519
67Nausea (HP:0002018)2.60293125
68Abnormal gallbladder morphology (HP:0012437)2.59254724
69Hepatocellular carcinoma (HP:0001402)2.58446974
70Increased muscle lipid content (HP:0009058)2.57236763
71Abnormality of pyrimidine metabolism (HP:0004353)2.55716881
72Abnormality of the preputium (HP:0100587)2.55597077
73Increased serum lactate (HP:0002151)2.53965978
74Acute encephalopathy (HP:0006846)2.51939350
75Abnormality of glycolysis (HP:0004366)2.49761691
76Increased serum pyruvate (HP:0003542)2.49761691
77Nephronophthisis (HP:0000090)2.48373447
78Degeneration of anterior horn cells (HP:0002398)2.48309145
79Abnormality of the anterior horn cell (HP:0006802)2.48309145
80Methylmalonic acidemia (HP:0002912)2.46474150
81Chromosomal breakage induced by crosslinking agents (HP:0003221)2.44815494
82Abnormality of nucleobase metabolism (HP:0010932)2.44748137
83Abolished electroretinogram (ERG) (HP:0000550)2.43113273
84Delayed CNS myelination (HP:0002188)2.42568937
85Chromsome breakage (HP:0040012)2.41557700
86Congenital primary aphakia (HP:0007707)2.39987756
87Abnormality of purine metabolism (HP:0004352)2.39263765
88Hepatocellular necrosis (HP:0001404)2.38715358
89Abnormality of complement system (HP:0005339)2.35167306
90Type I transferrin isoform profile (HP:0003642)2.34590638
91Vomiting (HP:0002013)2.34153294
92Lactic acidosis (HP:0003128)2.33834084
93Acanthocytosis (HP:0001927)2.33036315
94Spontaneous abortion (HP:0005268)2.31453460
95Renal Fanconi syndrome (HP:0001994)2.30687037
96Increased intramyocellular lipid droplets (HP:0012240)2.30506293
97Pancreatitis (HP:0001733)2.30274289
98Irritability (HP:0000737)2.28821890
99Decreased activity of mitochondrial respiratory chain (HP:0008972)2.28059988
100Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.28059988
101Birth length less than 3rd percentile (HP:0003561)2.24708212
102Gait imbalance (HP:0002141)2.23282137
103Abnormality of the labia minora (HP:0012880)2.22981340
104Spastic diplegia (HP:0001264)2.20791832
105Nephrogenic diabetes insipidus (HP:0009806)2.18730153
106Duodenal stenosis (HP:0100867)2.16816492
107Small intestinal stenosis (HP:0012848)2.16816492
108Steatorrhea (HP:0002570)2.16627552
109Aplasia/Hypoplasia of the tongue (HP:0010295)2.16275183
110Myelodysplasia (HP:0002863)2.16217765
111Sensorimotor neuropathy (HP:0007141)2.13964962
112Exertional dyspnea (HP:0002875)2.13154173
113Poikilocytosis (HP:0004447)2.11554333
114Abnormality of the renal cortex (HP:0011035)2.10229700
115Lipid accumulation in hepatocytes (HP:0006561)2.10076683
116Neonatal onset (HP:0003623)2.09600963
117Clubbing of toes (HP:0100760)2.09441244
118Ragged-red muscle fibers (HP:0003200)2.08939973
119Sloping forehead (HP:0000340)2.08741505
120Proximal tubulopathy (HP:0000114)2.08541413
121Renal cortical cysts (HP:0000803)2.08503265
122Hypertriglyceridemia (HP:0002155)2.06598598
123Abnormal mitochondria in muscle tissue (HP:0008316)2.06089488
124Abnormality of cells of the erythroid lineage (HP:0012130)2.05408567
125Cerebral hemorrhage (HP:0001342)2.04873766
126Reticulocytosis (HP:0001923)2.03902196
127Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03743302
128Abnormal protein N-linked glycosylation (HP:0012347)2.03743302
129Abnormal protein glycosylation (HP:0012346)2.03743302
130Abnormal glycosylation (HP:0012345)2.03743302
131Abnormal number of erythroid precursors (HP:0012131)2.03419945
132Abnormality of urine glucose concentration (HP:0011016)2.02715620
133Glycosuria (HP:0003076)2.02715620
134Methylmalonic aciduria (HP:0012120)2.01770528
135Conjugated hyperbilirubinemia (HP:0002908)2.01743379
136Abnormality of iron homeostasis (HP:0011031)2.01497443
137Congenital stationary night blindness (HP:0007642)2.01255476
138Abnormality of the gallbladder (HP:0005264)2.00169250
139Increased serum ferritin (HP:0003281)2.00151457
140Abnormal cartilage morphology (HP:0002763)1.99382965
141Optic disc pallor (HP:0000543)1.99002411
142Respiratory failure (HP:0002878)1.98000126
143Abnormality of the renal medulla (HP:0100957)1.97750232
144Polycythemia (HP:0001901)1.97240681
145Acute necrotizing encephalopathy (HP:0006965)1.96707772
146Acute hepatic failure (HP:0006554)1.95601784
147Congenital, generalized hypertrichosis (HP:0004540)1.94908942
148Systemic lupus erythematosus (HP:0002725)1.94790484
149Rhabdomyolysis (HP:0003201)1.94106742
150Sclerocornea (HP:0000647)1.92529297
151Mitochondrial inheritance (HP:0001427)1.91937825
152Abnormality of the duodenum (HP:0002246)1.91374502
153Myoglobinuria (HP:0002913)1.91000604
154Late onset (HP:0003584)1.90499155
155Astigmatism (HP:0000483)1.90081102
156Panhypogammaglobulinemia (HP:0003139)1.89325102
157Genital tract atresia (HP:0001827)1.86787835
158Exercise intolerance (HP:0003546)1.85168749
159Abnormality of renal resorption (HP:0011038)1.83550842
160Male pseudohermaphroditism (HP:0000037)1.82901476
161Vaginal atresia (HP:0000148)1.81768484
162Abnormality of the prostate (HP:0008775)1.75911784
163Absent thumb (HP:0009777)1.74381130
164Neoplasm of the adrenal gland (HP:0100631)1.73548839
165Hypothermia (HP:0002045)1.73296598
166Absent/shortened dynein arms (HP:0200106)1.73291652
167Dynein arm defect of respiratory motile cilia (HP:0012255)1.73291652
168Atrophy/Degeneration involving motor neurons (HP:0007373)1.72828159
169Reduced antithrombin III activity (HP:0001976)1.71968496
170Triphalangeal thumb (HP:0001199)1.70952522
171Type II lissencephaly (HP:0007260)1.69687400
172Abnormality of B cell number (HP:0010975)1.68734834
173Poor coordination (HP:0002370)1.66248636
174Leukodystrophy (HP:0002415)1.63099657
175Pancytopenia (HP:0001876)1.63094504

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.18974481
2TRIB33.14189158
3PKN23.11160704
4STK162.72639855
5ERN12.61434551
6ZAK2.57888545
7WNK32.50901728
8NME22.49321868
9MAP4K22.40108002
10FRK2.40082144
11PLK42.38954430
12VRK22.38150855
13TGFBR12.37500912
14TRIM282.31055088
15FGFR42.26359062
16MST42.22964906
17NEK12.18179215
18NUAK12.14560479
19SRPK12.01095426
20TYK21.98270977
21SIK11.95779414
22ARAF1.95145095
23CDC71.86657797
24KDR1.78957385
25PDK41.77952229
26PDK31.77952229
27TAOK21.77221874
28ACVR1B1.73131277
29VRK11.72730785
30INSRR1.71274116
31NEK21.65441195
32PLK31.60373356
33BRSK21.58962183
34TTK1.58819765
35TIE11.57852468
36MKNK11.54467982
37LRRK21.52754294
38MAP2K31.51588210
39EIF2AK31.47796808
40WEE11.47707360
41MAP3K111.42399450
42BUB11.40460262
43BCR1.40128496
44NEK91.39766690
45MAP2K61.39762316
46MKNK21.37675824
47PIM21.35642349
48ABL21.35215793
49MAP2K41.35023240
50EIF2AK11.34403647
51DYRK31.32507195
52TBK11.30553301
53MAP3K41.26305340
54TNIK1.25230239
55TLK11.23949251
56CSNK1G11.18520129
57FLT31.17388675
58ADRBK21.13360200
59ERBB31.12038556
60PLK21.11131575
61MAP2K71.08837788
62PLK11.08174584
63LIMK11.06527171
64PDK21.05219405
65TAF11.02270755
66DYRK21.02071559
67ATR0.99459977
68TNK20.95726375
69TESK10.94538813
70CSNK1G20.92944029
71NME10.89473001
72BMPR1B0.88797135
73MAPK130.86923876
74DYRK1B0.85276469
75ZAP700.84797513
76CSNK1A1L0.81929170
77STK30.81064660
78CDK80.80322991
79EIF2AK20.80115439
80BMPR20.78538384
81BLK0.78033055
82RPS6KA40.77243348
83ATM0.76654715
84PIK3CG0.75180703
85MAP3K60.75093554
86MAP3K130.74449791
87CHEK20.74360483
88BRAF0.74035057
89AURKB0.72629668
90EPHB10.71149666
91KIT0.70677009
92MAP3K50.69771466
93MAPK40.68794610
94CCNB10.68446149
95BRSK10.67746528
96JAK20.67668307
97TESK20.67239713
98DAPK10.66997138
99MAP2K10.60987623
100ILK0.60830982
101MAPK110.60600680
102SCYL20.60110532
103FER0.59538144
104MAP3K120.58919950
105MAP3K70.58508538
106PINK10.58290263
107MYLK0.58203535
108TAOK30.58196687
109PTK60.58030376
110EPHA30.57359820
111OBSCN0.56744565
112MAPK120.56247835
113STK40.56194870
114RPS6KA50.54681289
115CSNK2A20.54422700
116TXK0.53588844
117CDK190.50787231
118NLK0.48809114
119TEC0.47923416
120CAMKK20.47887288
121CAMKK10.47245722
122DAPK30.46228454
123CDK30.45442441
124PRKAA10.45409761
125PRKACG0.45382676
126PBK0.45151192
127AURKA0.44960422
128CDK70.44840995
129MATK0.44382542
130MAPKAPK30.43723527
131RPS6KB20.42805515
132SIK30.42405204
133MUSK0.41986334
134BTK0.41924055
135TGFBR20.41861068
136PASK0.40832195
137CSNK1G30.40625500
138TSSK60.40170509
139STK240.40137558
140SYK0.39077743
141ITK0.38437625
142MAP4K10.38163316
143CSNK2A10.36209589
144JAK30.35907298
145ADRBK10.35768183
146MAP3K80.35422176
147IKBKE0.35301175
148PRKACB0.35151515
149CSNK1A10.34040474
150RET0.33372326
151LYN0.33049988
152STK38L0.32539017
153ERBB20.31984460
154CHEK10.31487141
155PRKCG0.30543433
156PRKCE0.30459452
157PAK30.30442479
158PRKAA20.30182141
159MAPKAPK50.30132724
160OXSR10.29042461
161PIM10.28836385
162GRK10.28742420
163MARK30.27963955

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.69517920
2Mismatch repair_Homo sapiens_hsa034303.56567003
3Homologous recombination_Homo sapiens_hsa034403.43712439
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.17349575
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.82834059
6Fanconi anemia pathway_Homo sapiens_hsa034602.79098619
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.73723209
8Fatty acid degradation_Homo sapiens_hsa000712.66808745
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64894212
10Non-homologous end-joining_Homo sapiens_hsa034502.64763421
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47707324
12Nitrogen metabolism_Homo sapiens_hsa009102.44407609
13Propanoate metabolism_Homo sapiens_hsa006402.42810595
14Arginine biosynthesis_Homo sapiens_hsa002202.39544535
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34513072
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.31647338
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26607692
18Peroxisome_Homo sapiens_hsa041462.23813245
19Base excision repair_Homo sapiens_hsa034102.21660674
20Tryptophan metabolism_Homo sapiens_hsa003802.18453524
21Nucleotide excision repair_Homo sapiens_hsa034202.13307085
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11182498
23Complement and coagulation cascades_Homo sapiens_hsa046102.10409081
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.09747868
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08395329
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05317388
27Butanoate metabolism_Homo sapiens_hsa006502.03579921
28Fatty acid metabolism_Homo sapiens_hsa012122.01026831
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.93782228
30Pyruvate metabolism_Homo sapiens_hsa006201.91331462
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.88275512
32Basal transcription factors_Homo sapiens_hsa030221.88183720
33Carbon metabolism_Homo sapiens_hsa012001.80620928
34PPAR signaling pathway_Homo sapiens_hsa033201.78026845
35Folate biosynthesis_Homo sapiens_hsa007901.76124672
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.71517050
37RNA degradation_Homo sapiens_hsa030181.69351195
38Biosynthesis of amino acids_Homo sapiens_hsa012301.68386786
39Fatty acid elongation_Homo sapiens_hsa000621.64063249
40beta-Alanine metabolism_Homo sapiens_hsa004101.63477595
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.59088584
42Selenocompound metabolism_Homo sapiens_hsa004501.58642397
43Chemical carcinogenesis_Homo sapiens_hsa052041.57091948
44Spliceosome_Homo sapiens_hsa030401.56726354
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.56149233
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54066463
47Histidine metabolism_Homo sapiens_hsa003401.51747163
48RNA transport_Homo sapiens_hsa030131.51421003
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48729924
50Caffeine metabolism_Homo sapiens_hsa002321.44282098
51Pentose phosphate pathway_Homo sapiens_hsa000301.39506279
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39288820
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.33558008
54Asthma_Homo sapiens_hsa053101.28953376
55Phenylalanine metabolism_Homo sapiens_hsa003601.27904021
56Vitamin B6 metabolism_Homo sapiens_hsa007501.22797771
57Sulfur relay system_Homo sapiens_hsa041221.22499175
58Sulfur metabolism_Homo sapiens_hsa009201.19065513
59Staphylococcus aureus infection_Homo sapiens_hsa051501.18262466
60Tyrosine metabolism_Homo sapiens_hsa003501.17880748
61Cell cycle_Homo sapiens_hsa041101.17722627
62Retinol metabolism_Homo sapiens_hsa008301.16516344
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15006744
64Proteasome_Homo sapiens_hsa030501.13028118
65Bile secretion_Homo sapiens_hsa049761.10749633
66ABC transporters_Homo sapiens_hsa020101.08676251
67Starch and sucrose metabolism_Homo sapiens_hsa005001.04032286
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00383891
69Fat digestion and absorption_Homo sapiens_hsa049750.99342193
70Steroid biosynthesis_Homo sapiens_hsa001000.97266230
71Phototransduction_Homo sapiens_hsa047440.94718647
72Ribosome_Homo sapiens_hsa030100.93907920
73Arginine and proline metabolism_Homo sapiens_hsa003300.91873564
74Parkinsons disease_Homo sapiens_hsa050120.89139437
75One carbon pool by folate_Homo sapiens_hsa006700.88509668
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84977435
77Oxidative phosphorylation_Homo sapiens_hsa001900.82732826
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.82039313
79Glutathione metabolism_Homo sapiens_hsa004800.81743394
80Vitamin digestion and absorption_Homo sapiens_hsa049770.77609394
81Allograft rejection_Homo sapiens_hsa053300.75187703
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74252026
83Fructose and mannose metabolism_Homo sapiens_hsa000510.74192525
84Primary immunodeficiency_Homo sapiens_hsa053400.73505509
85Metabolic pathways_Homo sapiens_hsa011000.71562499
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.70439187
87Autoimmune thyroid disease_Homo sapiens_hsa053200.64916145
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.62696942
89Glycerolipid metabolism_Homo sapiens_hsa005610.62307375
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58110223
91Pyrimidine metabolism_Homo sapiens_hsa002400.55666511
92Galactose metabolism_Homo sapiens_hsa000520.53073968
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53017251
94Type I diabetes mellitus_Homo sapiens_hsa049400.52660882
95p53 signaling pathway_Homo sapiens_hsa041150.52607665
96Systemic lupus erythematosus_Homo sapiens_hsa053220.52118089
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51224007
98Oocyte meiosis_Homo sapiens_hsa041140.50614732
99Arachidonic acid metabolism_Homo sapiens_hsa005900.47002075
100Ether lipid metabolism_Homo sapiens_hsa005650.45915330
101Fatty acid biosynthesis_Homo sapiens_hsa000610.42939010
102mRNA surveillance pathway_Homo sapiens_hsa030150.42340878
103Graft-versus-host disease_Homo sapiens_hsa053320.41895333
104Huntingtons disease_Homo sapiens_hsa050160.40676382
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39785207
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39736322
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39435982
108Alzheimers disease_Homo sapiens_hsa050100.37505705
109Antigen processing and presentation_Homo sapiens_hsa046120.35504850
110Regulation of autophagy_Homo sapiens_hsa041400.31051735
111Olfactory transduction_Homo sapiens_hsa047400.30510402
112Hematopoietic cell lineage_Homo sapiens_hsa046400.29803959
113Epstein-Barr virus infection_Homo sapiens_hsa051690.27827998
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.26275239
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26094297
116Protein export_Homo sapiens_hsa030600.24443185
117Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.24006841
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.23648454
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21857887
120Lysine degradation_Homo sapiens_hsa003100.20941606
121Insulin resistance_Homo sapiens_hsa049310.14971996
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14176538
123Linoleic acid metabolism_Homo sapiens_hsa005910.11458352
124RNA polymerase_Homo sapiens_hsa030200.10182463
125Purine metabolism_Homo sapiens_hsa002300.08280577
126Prion diseases_Homo sapiens_hsa050200.05140265
127AMPK signaling pathway_Homo sapiens_hsa041520.04742601
128Cardiac muscle contraction_Homo sapiens_hsa042600.04400646
129N-Glycan biosynthesis_Homo sapiens_hsa005100.04046256
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.03308715
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.01131411
132Legionellosis_Homo sapiens_hsa051340.00107033
133DNA replication_Homo sapiens_hsa03030-0.0265959
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.0248913
135Insulin signaling pathway_Homo sapiens_hsa04910-0.0009265

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