BLVRA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.07156976
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.62655654
3positive regulation by symbiont of host defense response (GO:0052509)4.66889015
4modulation by symbiont of host defense response (GO:0052031)4.66889015
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.66889015
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.66889015
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.66889015
8modulation by symbiont of host immune response (GO:0052553)4.66889015
9respiratory burst (GO:0045730)4.22786958
10immunoglobulin mediated immune response (GO:0016064)4.19496206
11eosinophil chemotaxis (GO:0048245)3.98448846
12negative regulation of interleukin-12 production (GO:0032695)3.86239785
13positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.84905343
14response to peptidoglycan (GO:0032494)3.82577491
15regulation of chronic inflammatory response (GO:0002676)3.79678520
16positive regulation of interferon-alpha production (GO:0032727)3.77799469
17regulation of interferon-beta biosynthetic process (GO:0045357)3.73045460
18neutrophil activation (GO:0042119)3.64925739
19macrophage activation involved in immune response (GO:0002281)3.64821570
20granulocyte activation (GO:0036230)3.61337417
21regulation of B cell receptor signaling pathway (GO:0050855)3.58724776
22regulation of interferon-alpha production (GO:0032647)3.56689620
23negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.56254652
24regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.56074799
25eosinophil migration (GO:0072677)3.49594573
26myeloid cell activation involved in immune response (GO:0002275)3.49223337
27superoxide anion generation (GO:0042554)3.46505812
28cellular response to interferon-beta (GO:0035458)3.42898681
29positive regulation of antigen processing and presentation (GO:0002579)3.42503084
30regulation of vitamin D biosynthetic process (GO:0060556)3.39903979
31phagosome maturation (GO:0090382)3.35830286
32cellular response to zinc ion (GO:0071294)3.33914788
33hydrogen peroxide biosynthetic process (GO:0050665)3.33715062
34defense response to protozoan (GO:0042832)3.31861205
35B cell mediated immunity (GO:0019724)3.30201967
36antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.30128354
37signal peptide processing (GO:0006465)3.29496949
38production of molecular mediator involved in inflammatory response (GO:0002532)3.25878359
39microglial cell activation (GO:0001774)3.20787704
40reactive oxygen species biosynthetic process (GO:1903409)3.17855839
41response to interferon-beta (GO:0035456)3.17822017
42positive regulation of gamma-delta T cell activation (GO:0046645)3.14585444
43response to type I interferon (GO:0034340)3.12777670
44purine nucleotide salvage (GO:0032261)3.10150486
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.08467058
46negative regulation of interleukin-17 production (GO:0032700)3.08130616
47positive regulation of type 2 immune response (GO:0002830)3.08015256
48Arp2/3 complex-mediated actin nucleation (GO:0034314)3.07863287
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.06458253
50response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.05516342
51response to host immune response (GO:0052572)3.05516342
52positive regulation of cellular amide metabolic process (GO:0034250)3.04983439
53cullin deneddylation (GO:0010388)3.04347338
54positive regulation of lymphocyte migration (GO:2000403)3.01814724
55negative regulation of mast cell activation (GO:0033004)3.01287687
56response to protozoan (GO:0001562)3.00383455
57regulation of podosome assembly (GO:0071801)3.00106560
58mast cell activation (GO:0045576)2.99940642
59proteasome assembly (GO:0043248)2.97224171
60positive regulation of monocyte chemotaxis (GO:0090026)2.95298511
61regulation of antigen processing and presentation (GO:0002577)2.93118043
62negative regulation of myeloid cell apoptotic process (GO:0033033)2.91720195
63regulation of inflammatory response to antigenic stimulus (GO:0002861)2.90322162
64positive regulation of macrophage differentiation (GO:0045651)2.89328007
65protein deneddylation (GO:0000338)2.89269069
66monocyte chemotaxis (GO:0002548)2.87706478
67positive regulation of T cell migration (GO:2000406)2.86075041
68regulation of immunoglobulin secretion (GO:0051023)2.85629933
69negative regulation of nitric oxide biosynthetic process (GO:0045019)2.84685542
70interferon-gamma-mediated signaling pathway (GO:0060333)2.82841368
71positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.81781291
72regulation of B cell differentiation (GO:0045577)2.81344166
73regulation of cellular amino acid metabolic process (GO:0006521)2.81071364
74positive regulation of B cell differentiation (GO:0045579)2.80306132
75regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.78642613
76NIK/NF-kappaB signaling (GO:0038061)2.78522716
77regulation of T cell migration (GO:2000404)2.77871980
78positive regulation of mast cell activation (GO:0033005)2.77822051
79myeloid dendritic cell activation (GO:0001773)2.76253296
80energy coupled proton transport, down electrochemical gradient (GO:0015985)2.76131203
81ATP synthesis coupled proton transport (GO:0015986)2.76131203
82T cell migration (GO:0072678)2.76046374
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75841866
84response to thyroid hormone (GO:0097066)2.75043333
85myeloid dendritic cell differentiation (GO:0043011)2.73974557
86regulation of mast cell activation (GO:0033003)2.73328662
87macrophage activation (GO:0042116)2.72522900
88antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.71869628
89regulation of lymphocyte migration (GO:2000401)2.71436543
90natural killer cell mediated cytotoxicity (GO:0042267)2.71234280
91natural killer cell mediated immunity (GO:0002228)2.71234280
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.71211657
93amino sugar catabolic process (GO:0046348)2.70636401
94positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.69897761
95regulation of mononuclear cell migration (GO:0071675)2.68924252
96positive regulation of chemokine biosynthetic process (GO:0045080)2.68624369
97T-helper 1 type immune response (GO:0042088)2.66898120
98positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.65176601
99glycosphingolipid catabolic process (GO:0046479)2.65095011
100antigen processing and presentation of endogenous antigen (GO:0019883)2.65084062
101lymphocyte chemotaxis (GO:0048247)2.64620912
102negative regulation of viral genome replication (GO:0045071)2.63571351
103leukocyte aggregation (GO:0070486)2.63287845
104myeloid leukocyte activation (GO:0002274)2.62878291
105leukocyte mediated cytotoxicity (GO:0001909)2.61712793
106signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.60449646
107intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.60449646
108regulation of interleukin-8 biosynthetic process (GO:0045414)2.60290477
109positive regulation of interleukin-10 production (GO:0032733)2.60283321
110positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60255604
111regulation of vitamin metabolic process (GO:0030656)2.59825112
112negative regulation of cytokine production involved in immune response (GO:0002719)2.59526228
113positive regulation of natural killer cell differentiation (GO:0032825)2.59414825
114lipopolysaccharide-mediated signaling pathway (GO:0031663)2.59003610
115positive regulation of prostaglandin secretion (GO:0032308)2.58481808
116positive regulation of alpha-beta T cell proliferation (GO:0046641)2.58469788
117pinocytosis (GO:0006907)2.57816065
118regulation of activation of Janus kinase activity (GO:0010533)2.57085603
119regulation of dendritic cell antigen processing and presentation (GO:0002604)2.56856731
120signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.56818960
121signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.56818960
122signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.56818960
123oligosaccharide catabolic process (GO:0009313)2.56398482
124cellular extravasation (GO:0045123)2.56360971
125respiratory electron transport chain (GO:0022904)2.55594693
126regulation of T-helper 1 cell differentiation (GO:0045625)2.54968737
127regulation of cytokine secretion involved in immune response (GO:0002739)2.54941427
128response to host (GO:0075136)2.54892602
129response to host defenses (GO:0052200)2.54892602
130response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.54892602
131negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.54829460
132negative regulation of ligase activity (GO:0051352)2.54829460
133regulation of interleukin-12 production (GO:0032655)2.54355614
134leukocyte degranulation (GO:0043299)2.53933474
135positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.53206613
136cellular response to thyroid hormone stimulus (GO:0097067)2.52297876
137type I interferon signaling pathway (GO:0060337)2.51678184
138cellular response to type I interferon (GO:0071357)2.51678184
139regulation of chemokine biosynthetic process (GO:0045073)2.51503592
140regulation of prostaglandin secretion (GO:0032306)2.50239173
141positive regulation of heat generation (GO:0031652)2.50099702
142platelet dense granule organization (GO:0060155)2.49831414
143deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.49488193
144electron transport chain (GO:0022900)2.49371241
145positive regulation of interferon-beta production (GO:0032728)2.49214580
146neutrophil mediated immunity (GO:0002446)2.49129196
147protein complex biogenesis (GO:0070271)2.48935785
148positive regulation of mast cell degranulation (GO:0043306)2.48656817
149positive regulation of mast cell activation involved in immune response (GO:0033008)2.48656817
150phagocytosis, engulfment (GO:0006911)2.48290249
151positive regulation of T-helper cell differentiation (GO:0045624)2.47477029
152signal transduction involved in DNA integrity checkpoint (GO:0072401)2.45511910
153signal transduction involved in DNA damage checkpoint (GO:0072422)2.45511910
154heme biosynthetic process (GO:0006783)2.45317449
155positive regulation of defense response to virus by host (GO:0002230)2.44090845
156positive regulation of NF-kappaB import into nucleus (GO:0042346)2.42464720
157regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.42357468
158dendritic cell differentiation (GO:0097028)2.42315434
159response to interferon-gamma (GO:0034341)2.41886076
160purine-containing compound salvage (GO:0043101)2.40744482
161chaperone-mediated protein transport (GO:0072321)2.39792726
162mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.39601536
163signal transduction involved in cell cycle checkpoint (GO:0072395)2.38968539
164positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.38696276
165cellular response to interferon-gamma (GO:0071346)2.38181836
166modulation of growth of symbiont involved in interaction with host (GO:0044144)2.38077167
167regulation of growth of symbiont in host (GO:0044126)2.38077167
168negative regulation of growth of symbiont in host (GO:0044130)2.38077167
169negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.38077167
170oxidative phosphorylation (GO:0006119)2.37424032

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.96864061
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.43242381
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.36838635
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.12017984
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.34561020
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.14362223
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.03379783
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02560321
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.85148795
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.79266939
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69765411
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69146195
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.60876180
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.53966429
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.52275179
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.47751379
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.44181978
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.43721330
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.40767945
20E2F7_22180533_ChIP-Seq_HELA_Human2.40068629
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.34107973
22SPI1_23547873_ChIP-Seq_NB4_Human2.33476085
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16290918
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.15302964
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12372583
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.09586248
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08242711
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06046449
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05489393
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.94729713
31* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.89523997
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81062865
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77423841
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75880650
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75432384
36ELK1_19687146_ChIP-ChIP_HELA_Human1.70268592
37VDR_23849224_ChIP-Seq_CD4+_Human1.66414485
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64223011
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63799870
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61668493
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61512570
42CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59945065
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57896011
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55003830
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51664342
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51390007
47* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50053189
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49896832
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49345609
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.48554708
51* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48109499
52* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.47373836
53MYB_26560356_Chip-Seq_TH2_Human1.43697288
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43512521
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42613045
56* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41455932
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40553199
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37802493
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37491034
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37209602
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37068723
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.35546868
63PU_27001747_Chip-Seq_BMDM_Mouse1.33650416
64DCP1A_22483619_ChIP-Seq_HELA_Human1.32019886
65TFEB_21752829_ChIP-Seq_HELA_Human1.28638894
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28502972
67SCL_19346495_ChIP-Seq_HPC-7_Human1.27211922
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26853127
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24419110
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22446281
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19502764
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19249371
73STAT1_20625510_ChIP-Seq_HELA_Human1.18732230
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17982511
75GATA3_26560356_Chip-Seq_TH2_Human1.17112612
76ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15758369
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15110112
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13310244
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12975996
80* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11770790
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10860531
82FOXP3_21729870_ChIP-Seq_TREG_Human1.10840249
83MYB_26560356_Chip-Seq_TH1_Human1.10736181
84RUNX_20019798_ChIP-Seq_JUKART_Human1.10222354
85XRN2_22483619_ChIP-Seq_HELA_Human1.09924029
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09891934
87VDR_24763502_ChIP-Seq_THP-1_Human1.08329993
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07951129
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06242405
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.05838015
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04944886
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04222968
93MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04000764
94GATA1_22025678_ChIP-Seq_K562_Human1.03837391
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.01394610
96CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00439989
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99833747
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99282991
99E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97172655
100ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97141697
101BCL6_27268052_Chip-Seq_Bcells_Human0.97039503
102HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97027289
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96703841
104ZNF263_19887448_ChIP-Seq_K562_Human0.96604111
105GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96269982
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94622781
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94329942
108* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94174026
109EGR1_19374776_ChIP-ChIP_THP-1_Human0.94083158
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93177026
111SPI1_23127762_ChIP-Seq_K562_Human0.88933231
112GABP_19822575_ChIP-Seq_HepG2_Human0.88401344
113VDR_24787735_ChIP-Seq_THP-1_Human0.87942570
114MYC_18555785_ChIP-Seq_MESCs_Mouse0.87242257
115PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86604974
116ELK1_22589737_ChIP-Seq_MCF10A_Human0.86452647
117FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.83687737
118MAF_26560356_Chip-Seq_TH1_Human0.83671338
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83132355
120PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.83013572
121EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82429771
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81362045
123HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81187851
124GATA3_27048872_Chip-Seq_THYMUS_Human0.80504557

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.77649775
2MP0009785_altered_susceptibility_to3.64690523
3MP0002148_abnormal_hypersensitivity_rea3.63278996
4MP0006082_CNS_inflammation3.41232136
5MP0005058_abnormal_lysosome_morphology3.36947298
6MP0003436_decreased_susceptibility_to3.22701709
7MP0003724_increased_susceptibility_to3.22549754
8MP0005671_abnormal_response_to3.22203370
9MP0002419_abnormal_innate_immunity3.06927216
10MP0005000_abnormal_immune_tolerance2.99937123
11MP0005025_abnormal_response_to2.80906934
12MP0001790_abnormal_immune_system2.59238151
13MP0005387_immune_system_phenotype2.59238151
14MP0002452_abnormal_antigen_presenting2.51008041
15MP0002723_abnormal_immune_serum2.42069093
16MP0001800_abnormal_humoral_immune2.34030813
17MP0000685_abnormal_immune_system2.30949303
18MP0001819_abnormal_immune_cell2.23833918
19MP0002420_abnormal_adaptive_immunity2.23522855
20MP0003191_abnormal_cellular_cholesterol2.19540364
21MP0005464_abnormal_platelet_physiology2.03406630
22MP0002405_respiratory_system_inflammati1.95624185
23MP0003186_abnormal_redox_activity1.94175208
24MP0004510_myositis1.93811052
25MP0009333_abnormal_splenocyte_physiolog1.92763461
26MP0002139_abnormal_hepatobiliary_system1.86160443
27MP0003172_abnormal_lysosome_physiology1.85143899
28MP0001853_heart_inflammation1.83355058
29MP0001533_abnormal_skeleton_physiology1.77163085
30MP0001845_abnormal_inflammatory_respons1.77059505
31MP0000343_altered_response_to1.74082709
32MP0009764_decreased_sensitivity_to1.69002101
33MP0008469_abnormal_protein_level1.68191048
34MP0003656_abnormal_erythrocyte_physiolo1.67969678
35MP0000716_abnormal_immune_system1.64347295
36MP0005310_abnormal_salivary_gland1.60094408
37MP0002398_abnormal_bone_marrow1.55690820
38MP0003300_gastrointestinal_ulcer1.50672692
39MP0000689_abnormal_spleen_morphology1.48400510
40MP0002006_tumorigenesis1.45592300
41MP0010155_abnormal_intestine_physiology1.43468658
42MP0003303_peritoneal_inflammation1.41090349
43MP0002429_abnormal_blood_cell1.40584949
44MP0002837_dystrophic_cardiac_calcinosis1.37175610
45MP0009840_abnormal_foam_cell1.37080844
46MP0003448_altered_tumor_morphology1.36591843
47MP0002166_altered_tumor_susceptibility1.35997889
48MP0003763_abnormal_thymus_physiology1.34889180
49MP0004782_abnormal_surfactant_physiolog1.33194525
50MP0005165_increased_susceptibility_to1.29620442
51MP0002722_abnormal_immune_system1.29340647
52MP0000858_altered_metastatic_potential1.28279975
53MP0002396_abnormal_hematopoietic_system1.24972279
54MP0000604_amyloidosis1.24860296
55MP0003195_calcinosis1.23177028
56MP0002998_abnormal_bone_remodeling1.22486518
57MP0008260_abnormal_autophagy1.18262941
58MP0005451_abnormal_body_composition1.14950575
59MP0004147_increased_porphyrin_level1.14818625
60MP0005174_abnormal_tail_pigmentation1.14239599
61MP0004947_skin_inflammation1.13838844
62MP0000015_abnormal_ear_pigmentation1.11839212
63MP0002254_reproductive_system_inflammat1.11333415
64MP0009765_abnormal_xenobiotic_induced1.10539485
65MP0003075_altered_response_to1.05916842
66MP0002933_joint_inflammation1.04713818
67MP0005397_hematopoietic_system_phenotyp1.04603682
68MP0001545_abnormal_hematopoietic_system1.04603682
69MP0010386_abnormal_urinary_bladder1.04187231
70MP0005164_abnormal_response_to1.02828597
71MP0003690_abnormal_glial_cell1.00452077
72MP0005166_decreased_susceptibility_to1.00141441
73MP0005319_abnormal_enzyme/_coenzyme0.98656900
74MP0001542_abnormal_bone_strength0.96747404
75MP0002876_abnormal_thyroid_physiology0.95190565
76MP0009763_increased_sensitivity_to0.95053950
77MP0001986_abnormal_taste_sensitivity0.94156444
78MP0003806_abnormal_nucleotide_metabolis0.91818778
79MP0000372_irregular_coat_pigmentation0.89750333
80MP0002132_abnormal_respiratory_system0.88884113
81MP0008004_abnormal_stomach_pH0.88146500
82MP0000490_abnormal_crypts_of0.87721895
83MP0001727_abnormal_embryo_implantation0.85537440
84MP0006035_abnormal_mitochondrial_morpho0.84997272
85MP0002877_abnormal_melanocyte_morpholog0.84347977
86MP0005379_endocrine/exocrine_gland_phen0.84268062
87MP0001764_abnormal_homeostasis0.82955522
88MP0005171_absent_coat_pigmentation0.82585263
89MP0005167_abnormal_blood-brain_barrier0.81854674
90MP0006036_abnormal_mitochondrial_physio0.80456892
91MP0009278_abnormal_bone_marrow0.80053375
92MP0002277_abnormal_respiratory_mucosa0.79832528
93MP0008875_abnormal_xenobiotic_pharmacok0.78918710
94MP0003646_muscle_fatigue0.78168282
95MP0006054_spinal_hemorrhage0.77368815
96MP0005408_hypopigmentation0.76452512
97MP0005584_abnormal_enzyme/coenzyme_acti0.75623579
98MP0000920_abnormal_myelination0.74451508
99MP0003866_abnormal_defecation0.73899742
100MP0005084_abnormal_gallbladder_morpholo0.73520142
101MP0005390_skeleton_phenotype0.73518978
102MP0000358_abnormal_cell_content/0.72891094
103MP0003950_abnormal_plasma_membrane0.71645866
104MP0001873_stomach_inflammation0.71618112
105MP0002136_abnormal_kidney_physiology0.70679898
106MP0000465_gastrointestinal_hemorrhage0.70636288
107MP0004883_abnormal_blood_vessel0.70625360
108MP0005266_abnormal_metabolism0.70287639
109MP0008058_abnormal_DNA_repair0.70275815
110MP0005075_abnormal_melanosome_morpholog0.70257060
111MP0003453_abnormal_keratinocyte_physiol0.69633552
112MP0001663_abnormal_digestive_system0.68363064
113MP0002163_abnormal_gland_morphology0.67972547
114MP0000609_abnormal_liver_physiology0.67163189
115MP0005535_abnormal_body_temperature0.65505559
116MP0003786_premature_aging0.65120968
117MP0009643_abnormal_urine_homeostasis0.64817129
118MP0001851_eye_inflammation0.63684197
119MP0000249_abnormal_blood_vessel0.62558410
120MP0000681_abnormal_thyroid_gland0.62557660
121MP0005636_abnormal_mineral_homeostasis0.61491254
122MP0001881_abnormal_mammary_gland0.61088247
123MP0003183_abnormal_peptide_metabolism0.60450106
124MP0005647_abnormal_sex_gland0.60232686
125MP0008873_increased_physiological_sensi0.59173212
126MP0003795_abnormal_bone_structure0.59064411
127MP0002332_abnormal_exercise_endurance0.57547814

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.40289999
2Recurrent bacterial skin infections (HP:0005406)5.68472047
3Vacuolated lymphocytes (HP:0001922)5.37922097
4Eczematoid dermatitis (HP:0000976)5.07347665
5Recurrent gram-negative bacterial infections (HP:0005420)4.45293184
6Abnormality of macrophages (HP:0004311)4.43560998
7Increased neuronal autofluorescent lipopigment (HP:0002074)3.84306277
8Elevated erythrocyte sedimentation rate (HP:0003565)3.77334378
9Increased cerebral lipofuscin (HP:0011813)3.75434863
10Recurrent skin infections (HP:0001581)3.59488685
11Systemic lupus erythematosus (HP:0002725)3.43538395
12Mediastinal lymphadenopathy (HP:0100721)3.40811513
13Myositis (HP:0100614)3.38385667
14Obstructive lung disease (HP:0006536)3.29946969
15Chronic obstructive pulmonary disease (HP:0006510)3.29946969
16Stomatitis (HP:0010280)3.21433509
17Gingivitis (HP:0000230)3.13994099
18Petechiae (HP:0000967)3.09499624
19Orchitis (HP:0100796)3.07677934
20Axonal loss (HP:0003447)3.07455453
21Dysostosis multiplex (HP:0000943)3.05684020
22Retrobulbar optic neuritis (HP:0100654)3.02719164
23Optic neuritis (HP:0100653)3.02719164
24Recurrent fungal infections (HP:0002841)2.97321961
25Hepatosplenomegaly (HP:0001433)2.93037619
26Basal ganglia calcification (HP:0002135)2.87336075
27Abnormality of glycolipid metabolism (HP:0010969)2.84195363
28Abnormality of liposaccharide metabolism (HP:0010968)2.84195363
29Abnormality of glycosphingolipid metabolism (HP:0004343)2.84195363
30Autoimmune thrombocytopenia (HP:0001973)2.80928957
31Increased serum ferritin (HP:0003281)2.75464247
32Acute necrotizing encephalopathy (HP:0006965)2.71439715
33Mitochondrial inheritance (HP:0001427)2.71378728
34Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.70500066
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.68949195
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.68949195
37Agnosia (HP:0010524)2.68483093
38Progressive neurologic deterioration (HP:0002344)2.68177967
39IgM deficiency (HP:0002850)2.60230650
40Mutism (HP:0002300)2.57940930
41Chronic mucocutaneous candidiasis (HP:0002728)2.57447667
42Recurrent cutaneous fungal infections (HP:0011370)2.57447667
43Increased IgM level (HP:0003496)2.57007106
44Abnormal mitochondria in muscle tissue (HP:0008316)2.56882978
45Recurrent viral infections (HP:0004429)2.53478501
46Purpura (HP:0000979)2.49897829
47Respiratory failure (HP:0002878)2.47794137
483-Methylglutaconic aciduria (HP:0003535)2.47640115
49Hepatocellular necrosis (HP:0001404)2.45862997
50Increased muscle lipid content (HP:0009058)2.45591006
51Urticaria (HP:0001025)2.44104123
52Prostate neoplasm (HP:0100787)2.43419162
53Poor head control (HP:0002421)2.42001169
54Hypertensive crisis (HP:0100735)2.41235096
55Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.40561971
56Vasculitis (HP:0002633)2.39947720
57Nuclear cataract (HP:0100018)2.36183702
58Increased hepatocellular lipid droplets (HP:0006565)2.36004954
59Exertional dyspnea (HP:0002875)2.35987084
60Meningitis (HP:0001287)2.35613601
61Increased CSF lactate (HP:0002490)2.33736817
62Hepatic necrosis (HP:0002605)2.31783298
63Cerebral edema (HP:0002181)2.31368075
64Acute encephalopathy (HP:0006846)2.30981521
65Abnormality of the prostate (HP:0008775)2.30344514
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29770671
67Abnormal protein N-linked glycosylation (HP:0012347)2.29770671
68Abnormal protein glycosylation (HP:0012346)2.29770671
69Abnormal glycosylation (HP:0012345)2.29770671
70Combined immunodeficiency (HP:0005387)2.29724390
71Lactic acidosis (HP:0003128)2.29600150
72Severe combined immunodeficiency (HP:0004430)2.29187257
73Nausea (HP:0002018)2.28641961
74Abnormality of aromatic amino acid family metabolism (HP:0004338)2.28295031
75Degeneration of anterior horn cells (HP:0002398)2.28176945
76Abnormality of the anterior horn cell (HP:0006802)2.28176945
77Generalized aminoaciduria (HP:0002909)2.27844871
78Abnormality of iron homeostasis (HP:0011031)2.26623005
79Recurrent pneumonia (HP:0006532)2.25040078
80Leukocytosis (HP:0001974)2.24622659
81Renal Fanconi syndrome (HP:0001994)2.24087787
82Increased serum pyruvate (HP:0003542)2.22880204
83Abnormality of T cell number (HP:0011839)2.22827035
84Pustule (HP:0200039)2.19727426
85Disinhibition (HP:0000734)2.18583881
86Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18215748
87Progressive macrocephaly (HP:0004481)2.14562865
88Reduced antithrombin III activity (HP:0001976)2.14504864
89CNS demyelination (HP:0007305)2.14378602
90Keratoconjunctivitis (HP:0001096)2.12039379
91Amyloidosis (HP:0011034)2.11973010
92Increased serum lactate (HP:0002151)2.11415423
93Glomerulonephritis (HP:0000099)2.11088085
94T lymphocytopenia (HP:0005403)2.10257822
95Lipid accumulation in hepatocytes (HP:0006561)2.08704322
96Exercise intolerance (HP:0003546)2.08038423
97Abnormal gallbladder physiology (HP:0012438)2.07998386
98Cholecystitis (HP:0001082)2.07998386
99Abnormality of the heme biosynthetic pathway (HP:0010472)2.07736689
100Periodontitis (HP:0000704)2.07029969
101Thyroiditis (HP:0100646)2.06656940
102Ragged-red muscle fibers (HP:0003200)2.05918592
103Abnormality of glycolysis (HP:0004366)2.05612889
104Pulmonary infiltrates (HP:0002113)2.04858052
105Anorexia (HP:0002039)2.04556264
106Pathologic fracture (HP:0002756)2.04442253
107Bone cyst (HP:0012062)2.04171100
108Osteomyelitis (HP:0002754)2.03516534
109Urinary glycosaminoglycan excretion (HP:0003541)2.02561028
110Mucopolysacchariduria (HP:0008155)2.02561028
111Esophageal neoplasm (HP:0100751)2.02078318
112Neoplasm of head and neck (HP:0012288)2.02078318
113Increased intramyocellular lipid droplets (HP:0012240)2.00872869
114Type I transferrin isoform profile (HP:0003642)1.99443885
115Chronic diarrhea (HP:0002028)1.98416457
116Gangrene (HP:0100758)1.96895269
117Abnormality of T cells (HP:0002843)1.95931846
118Polyneuropathy (HP:0001271)1.95561898
119Dicarboxylic aciduria (HP:0003215)1.95171832
120Abnormality of dicarboxylic acid metabolism (HP:0010995)1.95171832
121Recurrent lower respiratory tract infections (HP:0002783)1.95170161
122Abnormality of transition element cation homeostasis (HP:0011030)1.94067116
123IgG deficiency (HP:0004315)1.92539496
124Cellulitis (HP:0100658)1.92176750
125Vertebral compression fractures (HP:0002953)1.92049858
126Abnormality of eosinophils (HP:0001879)1.92017524
127Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91301144
128Thrombocytosis (HP:0001894)1.88478916
129Encephalitis (HP:0002383)1.88143533
130Loss of speech (HP:0002371)1.87589018
131Prolonged neonatal jaundice (HP:0006579)1.86729179
132Chronic otitis media (HP:0000389)1.86152156
133Keratoconjunctivitis sicca (HP:0001097)1.83344388
134Hypergammaglobulinemia (HP:0010702)1.82598197
135Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82222469
136Abnormality of polysaccharide metabolism (HP:0011012)1.82222469
137Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82222469

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.32033209
2BLK3.30540765
3MAP3K143.18673320
4MAP3K122.99517355
5NME22.93990590
6RIPK42.87058443
7PBK2.85946149
8IRAK42.84610508
9TXK2.68029618
10CAMKK22.67615863
11NEK92.66511816
12TBK12.51045934
13MAP4K12.48537637
14BCKDK2.35725922
15PDK22.24145543
16MST42.21479126
17PIM22.17428445
18KIT1.98821741
19IRAK31.85406283
20TYK21.82943075
21EIF2AK11.80832369
22TEC1.80112716
23JAK31.74908614
24IKBKE1.68511621
25EIF2AK31.65609822
26IKBKB1.61429106
27GRK71.58475547
28BMPR21.52010627
29SYK1.47072034
30NEK11.43148583
31ARAF1.42800814
32STK161.34131257
33CSF1R1.30089145
34LYN1.28479345
35BTK1.27478131
36ZAP701.25599169
37BUB11.25275594
38MAP3K31.19869684
39KDR1.17828562
40BMPR1B1.14660560
41CDK191.14614452
42MAP4K21.13168678
43ABL21.10967874
44LCK1.08481251
45MAP3K131.08283542
46CCNB11.08176354
47EIF2AK21.03221014
48MYLK1.03121939
49MAP3K110.98856826
50CAMK1D0.97109851
51CDK80.95871069
52SIK30.89321588
53MOS0.89159724
54DAPK10.85800595
55PIM10.85293292
56MAP3K50.84923711
57ADRBK20.83832440
58OXSR10.83048746
59MAP2K30.82113979
60YES10.81383933
61DDR20.77098174
62CASK0.77009763
63TRPM70.76752196
64CSK0.76712026
65ERN10.76485316
66CLK10.76019018
67TGFBR20.75739629
68TAOK30.74924346
69PRKCD0.74471331
70JAK10.73856184
71MUSK0.72867574
72CSNK1G30.72199973
73TESK20.70404668
74SCYL20.66971186
75FGR0.65552203
76ITK0.65230318
77TESK10.64956325
78STK40.64225946
79ZAK0.63975985
80TLK10.62691825
81HCK0.61917138
82MARK30.61854856
83VRK10.61666476
84ILK0.56503506
85ACVR1B0.55566178
86MATK0.52431621
87RPS6KA40.51927918
88JAK20.50551020
89PAK10.49349505
90TIE10.47411738
91BRSK20.47240737
92DAPK30.46263990
93LIMK10.46239056
94CAMKK10.45057628
95PRKCQ0.44833107
96TSSK60.44830048
97PAK40.43109164
98SRPK10.42878898
99TRIM280.41221046
100STK240.40920674
101STK100.40819439
102PRPF4B0.40082056
103FES0.39900467
104LRRK20.39588496
105PLK40.39047432
106TAOK20.38867056
107MAP2K60.38100833
108CSNK1G20.37881763
109CSNK1A1L0.37784520
110NME10.37241161
111CHUK0.36861811
112ABL10.36081691
113PLK20.34703512
114NUAK10.33940068
115CSNK2A10.33492192
116MAP3K10.33348876
117GRK60.33244542
118RPS6KA50.32426286
119AURKA0.32423951
120TAOK10.32263720
121MAPKAPK50.31170963
122GRK50.30934165
123MAPKAPK20.30531800
124IRAK20.30061889
125RPS6KA60.29971151
126CSNK2A20.29370785
127EGFR0.28652978

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.07525214
2Oxidative phosphorylation_Homo sapiens_hsa001902.82583789
3Graft-versus-host disease_Homo sapiens_hsa053322.61334725
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.56882525
5Rheumatoid arthritis_Homo sapiens_hsa053232.52074246
6Allograft rejection_Homo sapiens_hsa053302.51950192
7Other glycan degradation_Homo sapiens_hsa005112.50917165
8Staphylococcus aureus infection_Homo sapiens_hsa051502.41843071
9Lysosome_Homo sapiens_hsa041422.36163407
10Leishmaniasis_Homo sapiens_hsa051402.28331426
11Collecting duct acid secretion_Homo sapiens_hsa049662.27773702
12Phagosome_Homo sapiens_hsa041452.17116839
13Legionellosis_Homo sapiens_hsa051342.14047183
14Parkinsons disease_Homo sapiens_hsa050122.03738331
15Asthma_Homo sapiens_hsa053101.95257473
16Protein export_Homo sapiens_hsa030601.86543733
17Tuberculosis_Homo sapiens_hsa051521.76495996
18Malaria_Homo sapiens_hsa051441.74885851
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74863948
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.72530841
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70288755
22Primary immunodeficiency_Homo sapiens_hsa053401.68953939
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.65991353
24DNA replication_Homo sapiens_hsa030301.65567907
25Type I diabetes mellitus_Homo sapiens_hsa049401.65457263
26Pertussis_Homo sapiens_hsa051331.64555889
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.63019785
28Antigen processing and presentation_Homo sapiens_hsa046121.60424263
29Sulfur metabolism_Homo sapiens_hsa009201.59461191
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58671376
31Hematopoietic cell lineage_Homo sapiens_hsa046401.53246207
32Measles_Homo sapiens_hsa051621.52810943
33Ribosome_Homo sapiens_hsa030101.51879439
34Alzheimers disease_Homo sapiens_hsa050101.47560605
35Osteoclast differentiation_Homo sapiens_hsa043801.42358603
36Autoimmune thyroid disease_Homo sapiens_hsa053201.39554584
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38873348
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.38156527
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31907791
40Huntingtons disease_Homo sapiens_hsa050161.30546644
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24599171
42Salmonella infection_Homo sapiens_hsa051321.21137322
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19234370
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.18534400
45Vibrio cholerae infection_Homo sapiens_hsa051101.15441761
46* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12549558
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03788727
48Shigellosis_Homo sapiens_hsa051311.03661606
49Apoptosis_Homo sapiens_hsa042101.00202889
50Mismatch repair_Homo sapiens_hsa034300.99679812
51Influenza A_Homo sapiens_hsa051640.99470931
52Homologous recombination_Homo sapiens_hsa034400.94302220
53Herpes simplex infection_Homo sapiens_hsa051680.90631291
54Base excision repair_Homo sapiens_hsa034100.88597238
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86756118
56RNA polymerase_Homo sapiens_hsa030200.86364428
57Nucleotide excision repair_Homo sapiens_hsa034200.84616444
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84390981
59Chemokine signaling pathway_Homo sapiens_hsa040620.82164373
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82151094
61Pyrimidine metabolism_Homo sapiens_hsa002400.79542587
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76928299
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76746922
64Carbon metabolism_Homo sapiens_hsa012000.76253371
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73654474
66Sphingolipid metabolism_Homo sapiens_hsa006000.71605288
67B cell receptor signaling pathway_Homo sapiens_hsa046620.71054464
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70823787
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70201919
70Tryptophan metabolism_Homo sapiens_hsa003800.69490736
71Non-homologous end-joining_Homo sapiens_hsa034500.69240869
72Folate biosynthesis_Homo sapiens_hsa007900.68716097
73TNF signaling pathway_Homo sapiens_hsa046680.68572396
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67173167
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65055094
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64754996
77African trypanosomiasis_Homo sapiens_hsa051430.64346547
78Arachidonic acid metabolism_Homo sapiens_hsa005900.63917135
79Viral myocarditis_Homo sapiens_hsa054160.63754442
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63714049
81Pentose phosphate pathway_Homo sapiens_hsa000300.62840943
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.59751420
83Toxoplasmosis_Homo sapiens_hsa051450.59553729
84Regulation of autophagy_Homo sapiens_hsa041400.59115331
85Galactose metabolism_Homo sapiens_hsa000520.58946053
86Renin-angiotensin system_Homo sapiens_hsa046140.58388072
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57228668
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56631568
89Steroid biosynthesis_Homo sapiens_hsa001000.55521083
90Sulfur relay system_Homo sapiens_hsa041220.54809736
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54602837
92Pyruvate metabolism_Homo sapiens_hsa006200.54278214
93N-Glycan biosynthesis_Homo sapiens_hsa005100.53277192
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52871552
95Glutathione metabolism_Homo sapiens_hsa004800.51001670
96Fatty acid metabolism_Homo sapiens_hsa012120.48169653
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46935001
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46428918
99One carbon pool by folate_Homo sapiens_hsa006700.45122651
100Epstein-Barr virus infection_Homo sapiens_hsa051690.42642478
101Fatty acid elongation_Homo sapiens_hsa000620.42381116
102Hepatitis B_Homo sapiens_hsa051610.41256291
103Propanoate metabolism_Homo sapiens_hsa006400.41064443
104Peroxisome_Homo sapiens_hsa041460.41000913
105Complement and coagulation cascades_Homo sapiens_hsa046100.39665438
106Spliceosome_Homo sapiens_hsa030400.38620711
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.38564193
108Ether lipid metabolism_Homo sapiens_hsa005650.37857523
109Synaptic vesicle cycle_Homo sapiens_hsa047210.37769149
110Systemic lupus erythematosus_Homo sapiens_hsa053220.34361859
111Histidine metabolism_Homo sapiens_hsa003400.33851719
112Metabolic pathways_Homo sapiens_hsa011000.33716271
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.30915638
114Purine metabolism_Homo sapiens_hsa002300.30643447
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30212456
116Hepatitis C_Homo sapiens_hsa051600.30182205
117Vitamin digestion and absorption_Homo sapiens_hsa049770.24830541
118Mineral absorption_Homo sapiens_hsa049780.23311958
119T cell receptor signaling pathway_Homo sapiens_hsa046600.23044517
120Fructose and mannose metabolism_Homo sapiens_hsa000510.22512460

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