BLVRB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)8.20226405
2protoporphyrinogen IX biosynthetic process (GO:0006782)7.89407149
3oxygen transport (GO:0015671)7.31450070
4heme biosynthetic process (GO:0006783)6.92984832
5gas transport (GO:0015669)6.51791570
6porphyrin-containing compound biosynthetic process (GO:0006779)6.15839161
7* heme metabolic process (GO:0042168)5.80898457
8tetrapyrrole biosynthetic process (GO:0033014)5.47567095
9* porphyrin-containing compound metabolic process (GO:0006778)5.18338832
10negative regulation of erythrocyte differentiation (GO:0045647)4.51876403
11erythrocyte maturation (GO:0043249)4.12488884
12neutrophil activation involved in immune response (GO:0002283)3.61511135
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.60477962
14cellular response to arsenic-containing substance (GO:0071243)3.58963734
15hydrogen peroxide biosynthetic process (GO:0050665)3.56935136
16aldehyde catabolic process (GO:0046185)3.56615765
17negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.48757373
18* tetrapyrrole metabolic process (GO:0033013)3.42337719
19glycosphingolipid catabolic process (GO:0046479)3.40716509
20amino sugar catabolic process (GO:0046348)3.33428245
21hemoglobin metabolic process (GO:0020027)3.27185629
22pigment biosynthetic process (GO:0046148)3.21991912
23DNA deamination (GO:0045006)3.14482229
24erythrocyte development (GO:0048821)3.14466062
25ribosomal small subunit assembly (GO:0000028)3.12216382
26reactive oxygen species biosynthetic process (GO:1903409)3.10062835
27glycolipid catabolic process (GO:0019377)3.08141611
28positive regulation of interferon-alpha production (GO:0032727)3.06959257
29pentose-phosphate shunt (GO:0006098)3.05584129
30GDP-mannose metabolic process (GO:0019673)3.03580137
31oligosaccharide catabolic process (GO:0009313)3.03562245
32pentose metabolic process (GO:0019321)3.00414870
33myeloid cell development (GO:0061515)2.97638061
34very-low-density lipoprotein particle assembly (GO:0034379)2.96148375
35regulation of mast cell degranulation (GO:0043304)2.95909629
36negative regulation of interleukin-12 production (GO:0032695)2.91672504
37N-acetylneuraminate metabolic process (GO:0006054)2.90335013
38granulocyte differentiation (GO:0030851)2.90153902
39response to peptidoglycan (GO:0032494)2.89447870
40response to arsenic-containing substance (GO:0046685)2.87296148
41positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.87059771
42regulation of interferon-alpha production (GO:0032647)2.86747965
43proteasome assembly (GO:0043248)2.86381540
44* pigment metabolic process (GO:0042440)2.86013818
45triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.82967056
46hydrogen peroxide catabolic process (GO:0042744)2.81087134
47immunoglobulin mediated immune response (GO:0016064)2.80182917
48modulation by virus of host process (GO:0019054)2.77194062
49plasma lipoprotein particle assembly (GO:0034377)2.75967984
50modulation by symbiont of host defense response (GO:0052031)2.74385915
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.74385915
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.74385915
53positive regulation by organism of defense response of other organism involved in symbiotic interact2.74385915
54modulation by symbiont of host immune response (GO:0052553)2.74385915
55positive regulation by symbiont of host defense response (GO:0052509)2.74385915
56cysteine metabolic process (GO:0006534)2.73632976
57viral transcription (GO:0019083)2.73465200
58response to interferon-beta (GO:0035456)2.71516589
59natural killer cell mediated cytotoxicity (GO:0042267)2.71421414
60natural killer cell mediated immunity (GO:0002228)2.71421414
61hydrogen peroxide metabolic process (GO:0042743)2.71070088
62respiratory burst (GO:0045730)2.70610874
63NADPH regeneration (GO:0006740)2.69302310
64regulation of response to osmotic stress (GO:0047484)2.68230319
65plasma lipoprotein particle clearance (GO:0034381)2.67253307
66modulation by symbiont of host cellular process (GO:0044068)2.66296113
67ceramide catabolic process (GO:0046514)2.65732948
68regulation of superoxide anion generation (GO:0032928)2.64154171
69response to nitrosative stress (GO:0051409)2.63971543
70macrophage activation involved in immune response (GO:0002281)2.62853569
71positive regulation of gamma-delta T cell activation (GO:0046645)2.62756562
72positive regulation of triglyceride lipase activity (GO:0061365)2.62684335
73positive regulation of lipoprotein lipase activity (GO:0051006)2.62684335
74response to thyroid hormone (GO:0097066)2.62164064
75translational termination (GO:0006415)2.61960717
76regulation of mast cell activation involved in immune response (GO:0033006)2.61285539
77potassium ion export (GO:0071435)2.60826734
78cellular response to thyroid hormone stimulus (GO:0097067)2.59026110
79regulation of cholesterol storage (GO:0010885)2.58413879
80detection of other organism (GO:0098543)2.57585336
81lysine metabolic process (GO:0006553)2.57048154
82lysine catabolic process (GO:0006554)2.57048154
83cellular response to interferon-beta (GO:0035458)2.55890093
84protein autoprocessing (GO:0016540)2.55729262
85response to oxygen radical (GO:0000305)2.55607017
86negative regulation of fatty acid biosynthetic process (GO:0045717)2.55031957
87one-carbon compound transport (GO:0019755)2.54424768
88deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.54314785
89cellular response to oxygen radical (GO:0071450)2.54022634
90removal of superoxide radicals (GO:0019430)2.54022634
91cellular response to superoxide (GO:0071451)2.54022634
92NAD biosynthetic process (GO:0009435)2.53638620
93purine-containing compound salvage (GO:0043101)2.53556432
94detection of bacterium (GO:0016045)2.52430060
95superoxide anion generation (GO:0042554)2.52264219
96lipopolysaccharide-mediated signaling pathway (GO:0031663)2.52257612
97erythrocyte differentiation (GO:0030218)2.51164618
98L-alpha-amino acid transmembrane transport (GO:1902475)2.49055785
99positive regulation of megakaryocyte differentiation (GO:0045654)2.48326641
100cellular response to zinc ion (GO:0071294)2.47687247
101phospholipid efflux (GO:0033700)2.47622233
102deoxyribose phosphate biosynthetic process (GO:0046385)2.47116484
1032-deoxyribonucleotide biosynthetic process (GO:0009265)2.47116484
104blood coagulation, intrinsic pathway (GO:0007597)2.46315480
105regulation of cholesterol esterification (GO:0010872)2.45881962
106pyridine nucleotide biosynthetic process (GO:0019363)2.44722594
107nicotinamide nucleotide biosynthetic process (GO:0019359)2.44722594
108granulocyte activation (GO:0036230)2.43959885
109folic acid-containing compound biosynthetic process (GO:0009396)2.43782142
110low-density lipoprotein particle clearance (GO:0034383)2.43765467
111protein carboxylation (GO:0018214)2.42550021
112peptidyl-glutamic acid carboxylation (GO:0017187)2.42550021
113neutrophil activation (GO:0042119)2.42261784
114glucose 6-phosphate metabolic process (GO:0051156)2.42053458
115antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.40470743
116negative regulation of myeloid cell apoptotic process (GO:0033033)2.39872763
117protein-lipid complex assembly (GO:0065005)2.39551561
118regulation of cytokine secretion involved in immune response (GO:0002739)2.39264007
119positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.39154058
120telomere maintenance via semi-conservative replication (GO:0032201)2.38916815
121glucose catabolic process (GO:0006007)2.36927531
122iron ion transport (GO:0006826)2.36496775
123detection of external biotic stimulus (GO:0098581)2.36394178
124positive regulation of chemokine biosynthetic process (GO:0045080)2.35155848
125autophagic vacuole fusion (GO:0000046)2.33507831
126pyrimidine-containing compound salvage (GO:0008655)2.32792280
127pyrimidine nucleoside salvage (GO:0043097)2.32792280
128response to lead ion (GO:0010288)2.32191539
129oxaloacetate metabolic process (GO:0006107)2.31670326
130cofactor biosynthetic process (GO:0051188)2.31452134
131regulation of erythrocyte differentiation (GO:0045646)2.30514499
132translational elongation (GO:0006414)2.30400411
133response to superoxide (GO:0000303)2.29571562
134transferrin transport (GO:0033572)2.29550136
135negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.28816611
136detection of molecule of bacterial origin (GO:0032490)2.28773256
137B cell mediated immunity (GO:0019724)2.28561386
138regulation of superoxide metabolic process (GO:0090322)2.28420328
139plasma lipoprotein particle organization (GO:0071827)2.27669725
140glucuronate metabolic process (GO:0019585)2.27617981
141uronic acid metabolic process (GO:0006063)2.27617981
142iron ion import (GO:0097286)2.27539959
143heme transport (GO:0015886)2.27508506
144cellular iron ion homeostasis (GO:0006879)2.26458957
145response to methylmercury (GO:0051597)2.25609610
146DNA strand elongation involved in DNA replication (GO:0006271)2.25224650
147eosinophil chemotaxis (GO:0048245)2.25221822
148copper ion transport (GO:0006825)2.24965459
149negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.24879045
150regulation of leukocyte degranulation (GO:0043300)2.24863448
151iron ion homeostasis (GO:0055072)2.24796902
152SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.24779768
153phagosome maturation (GO:0090382)2.24672537
154proline biosynthetic process (GO:0006561)2.22920190
155nucleobase-containing small molecule interconversion (GO:0015949)2.22485735
156viral protein processing (GO:0019082)2.22302501
157myeloid cell activation involved in immune response (GO:0002275)2.22032435
158regulation of myeloid leukocyte mediated immunity (GO:0002886)2.21554395
159regulation of interferon-beta biosynthetic process (GO:0045357)2.17014843

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.67006057
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.11726111
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.77299158
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.68486537
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.43302112
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.10061539
7GATA1_22025678_ChIP-Seq_K562_Human2.60213572
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.53254234
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.40429088
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.34756805
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.34641470
12* RXR_22158963_ChIP-Seq_LIVER_Mouse2.34483829
13* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.22335157
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.18478033
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.13416727
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.04367015
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98303637
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96024999
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93329749
20* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.91649067
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.89799129
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.88581419
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.86133327
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.84766720
25SCL_19346495_ChIP-Seq_HPC-7_Human1.83461140
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80875271
27GATA1_22383799_ChIP-Seq_G1ME_Mouse1.80666389
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78571355
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77417514
30* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75589704
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.75001338
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.73454130
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71973922
34* NCOR1_26117541_ChIP-Seq_K562_Human1.71961627
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71812546
36* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71246153
37* GATA1_19941827_ChIP-Seq_MEL_Mouse1.71120597
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70426794
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69602481
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.63463334
41LXR_22292898_ChIP-Seq_THP-1_Human1.63456206
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62889081
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.60681971
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58282727
45* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.57690596
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56257298
47ZNF263_19887448_ChIP-Seq_K562_Human1.55874182
48* LXR_22158963_ChIP-Seq_LIVER_Mouse1.54753717
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54728364
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53115367
51DCP1A_22483619_ChIP-Seq_HELA_Human1.50984774
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.50482449
53SPI1_23127762_ChIP-Seq_K562_Human1.46394767
54* GATA1_19941826_ChIP-Seq_K562_Human1.45983296
55FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45589971
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45034210
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44804764
58VDR_23849224_ChIP-Seq_CD4+_Human1.44695410
59* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.43336191
60SPI1_23547873_ChIP-Seq_NB4_Human1.43036840
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41946921
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41892872
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41659811
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40751429
65* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39646415
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38460627
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38377817
68* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37745251
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35277630
70VDR_21846776_ChIP-Seq_THP-1_Human1.33284456
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32479158
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.31335380
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30281656
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29340348
75* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29145223
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28998581
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28131333
78BCOR_27268052_Chip-Seq_Bcells_Human1.28034493
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27713580
80BCL6_27268052_Chip-Seq_Bcells_Human1.26606400
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26588939
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25860729
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.25322679
84* RACK7_27058665_Chip-Seq_MCF-7_Human1.24069659
85XRN2_22483619_ChIP-Seq_HELA_Human1.23344077
86TFEB_21752829_ChIP-Seq_HELA_Human1.23256343
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22646392
88RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21988104
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21507242
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21130664
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20364301
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20288468
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19549266
94RUNX1_22412390_ChIP-Seq_EML_Mouse1.18732035
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17082357
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17006942
97UTX_26944678_Chip-Seq_JUKART_Human1.14336980
98* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14114142
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14106660
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12569887
101P68_20966046_ChIP-Seq_HELA_Human1.11532143
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10826362
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09626275
104MAF_26560356_Chip-Seq_TH2_Human1.09388258
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09261489
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07999493
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07774076
108GABP_19822575_ChIP-Seq_HepG2_Human1.07286822
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07055474
110SA1_27219007_Chip-Seq_ERYTHROID_Human1.06539726
111FOXP3_21729870_ChIP-Seq_TREG_Human1.06418199
112TCF7_22412390_ChIP-Seq_EML_Mouse1.05737969
113E2F1_21310950_ChIP-Seq_MCF-7_Human1.05341018
114LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04642807
115VDR_24763502_ChIP-Seq_THP-1_Human1.03813021
116MAF_26560356_Chip-Seq_TH1_Human1.03554809
117ELK1_19687146_ChIP-ChIP_HELA_Human1.01167366
118* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00276908
119MYC_22102868_ChIP-Seq_BL_Human0.99849841
120CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95325061
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93708455
122AR_21909140_ChIP-Seq_LNCAP_Human0.93423458
123TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93243988
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93105062
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92817151
126LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92389132
127CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90745649
128* GATA2_19941826_ChIP-Seq_K562_Human0.88559740

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.15136393
2MP0004147_increased_porphyrin_level4.47271337
3MP0003806_abnormal_nucleotide_metabolis3.05524755
4MP0002139_abnormal_hepatobiliary_system3.02405188
5MP0003186_abnormal_redox_activity2.99286578
6MP0001835_abnormal_antigen_presentation2.90786683
7MP0005451_abnormal_body_composition2.82339322
8MP0003436_decreased_susceptibility_to2.64305673
9MP0005397_hematopoietic_system_phenotyp2.54007439
10MP0001545_abnormal_hematopoietic_system2.54007439
11MP0009840_abnormal_foam_cell2.52095488
12MP0005360_urolithiasis2.51175459
13MP0009785_altered_susceptibility_to2.34191767
14MP0003191_abnormal_cellular_cholesterol2.20011331
15MP0008260_abnormal_autophagy2.19768410
16MP0002148_abnormal_hypersensitivity_rea2.17509034
17MP0005085_abnormal_gallbladder_physiolo2.17234694
18MP0005083_abnormal_biliary_tract2.13212668
19MP0003724_increased_susceptibility_to2.10515091
20MP0006082_CNS_inflammation2.09660332
21MP0005025_abnormal_response_to2.00229778
22MP0009764_decreased_sensitivity_to1.97196692
23MP0002419_abnormal_innate_immunity1.92690396
24MP0000685_abnormal_immune_system1.90747139
25MP0005000_abnormal_immune_tolerance1.89502542
26MP0002132_abnormal_respiratory_system1.85080302
27MP0008875_abnormal_xenobiotic_pharmacok1.77459120
28MP0001853_heart_inflammation1.77042044
29MP0005464_abnormal_platelet_physiology1.75454805
30MP0006054_spinal_hemorrhage1.71712481
31MP0008469_abnormal_protein_level1.59324488
32MP0002452_abnormal_antigen_presenting1.59089022
33MP0005671_abnormal_response_to1.58891039
34MP0003195_calcinosis1.58645928
35MP0005365_abnormal_bile_salt1.58467059
36MP0001800_abnormal_humoral_immune1.52482457
37MP0003303_peritoneal_inflammation1.52190447
38MP0002723_abnormal_immune_serum1.50450322
39MP0005387_immune_system_phenotype1.49432270
40MP0001790_abnormal_immune_system1.49432270
41MP0009333_abnormal_splenocyte_physiolog1.49404326
42MP0002405_respiratory_system_inflammati1.47824322
43MP0005058_abnormal_lysosome_morphology1.45320264
44MP0005636_abnormal_mineral_homeostasis1.44672663
45MP0000609_abnormal_liver_physiology1.37635012
46MP0002398_abnormal_bone_marrow1.34421692
47MP0002138_abnormal_hepatobiliary_system1.33277650
48MP0001845_abnormal_inflammatory_respons1.32995978
49MP0003693_abnormal_embryo_hatching1.32570793
50MP0005319_abnormal_enzyme/_coenzyme1.31911688
51MP0010329_abnormal_lipoprotein_level1.30208317
52MP0001819_abnormal_immune_cell1.29936647
53MP0003111_abnormal_nucleus_morphology1.28997353
54MP0002420_abnormal_adaptive_immunity1.28289482
55MP0000689_abnormal_spleen_morphology1.28279503
56MP0000343_altered_response_to1.26470065
57MP0001764_abnormal_homeostasis1.23866767
58MP0004947_skin_inflammation1.21820107
59MP0000015_abnormal_ear_pigmentation1.20200072
60MP0003453_abnormal_keratinocyte_physiol1.20184340
61MP0002722_abnormal_immune_system1.20146863
62MP0009763_increased_sensitivity_to1.19711978
63MP0001533_abnormal_skeleton_physiology1.19368190
64MP0000490_abnormal_crypts_of1.19274082
65MP0002429_abnormal_blood_cell1.18664628
66MP0003300_gastrointestinal_ulcer1.17897783
67MP0003075_altered_response_to1.16629014
68MP0006036_abnormal_mitochondrial_physio1.15919251
69MP0000858_altered_metastatic_potential1.12589610
70MP0005584_abnormal_enzyme/coenzyme_acti1.09639531
71MP0000716_abnormal_immune_system1.09449969
72MP0010307_abnormal_tumor_latency1.06908402
73MP0005377_hearing/vestibular/ear_phenot1.05423584
74MP0003878_abnormal_ear_physiology1.05423584
75MP0000598_abnormal_liver_morphology1.01394275
76MP0010155_abnormal_intestine_physiology0.97980381
77MP0002396_abnormal_hematopoietic_system0.97278762
78MP0003077_abnormal_cell_cycle0.97191321
79MP0003252_abnormal_bile_duct0.96179033
80MP0003011_delayed_dark_adaptation0.95311000
81MP0010094_abnormal_chromosome_stability0.93823520
82MP0006035_abnormal_mitochondrial_morpho0.93400034
83MP0005332_abnormal_amino_acid0.92548334
84MP0005166_decreased_susceptibility_to0.92002939
85MP0005164_abnormal_response_to0.90983111
86MP0005075_abnormal_melanosome_morpholog0.90274530
87MP0002006_tumorigenesis0.90019790
88MP0009643_abnormal_urine_homeostasis0.89884427
89MP0001727_abnormal_embryo_implantation0.87152629
90MP0003448_altered_tumor_morphology0.86503670
91MP0004957_abnormal_blastocyst_morpholog0.84303246
92MP0009278_abnormal_bone_marrow0.84221266
93MP0004510_myositis0.83827732
94MP0005310_abnormal_salivary_gland0.82822343
95MP0002332_abnormal_exercise_endurance0.80799300
96MP0008995_early_reproductive_senescence0.79082052
97MP0000371_diluted_coat_color0.78870618
98MP0004782_abnormal_surfactant_physiolog0.77266892
99MP0008057_abnormal_DNA_replication0.76615797
100MP0000747_muscle_weakness0.76168800
101MP0002019_abnormal_tumor_incidence0.75594567
102MP0005376_homeostasis/metabolism_phenot0.75472507
103MP0000604_amyloidosis0.75346044
104MP0009931_abnormal_skin_appearance0.74921220
105MP0003172_abnormal_lysosome_physiology0.74156739
106MP0000358_abnormal_cell_content/0.73007701
107MP0002254_reproductive_system_inflammat0.70261615
108MP0008004_abnormal_stomach_pH0.69460555
109MP0004185_abnormal_adipocyte_glucose0.69348747
110MP0004808_abnormal_hematopoietic_stem0.69293719
111MP0000313_abnormal_cell_death0.69074047
112MP0008873_increased_physiological_sensi0.69012452
113MP0002118_abnormal_lipid_homeostasis0.68991852
114MP0004019_abnormal_vitamin_homeostasis0.68585401
115MP0002136_abnormal_kidney_physiology0.68440525
116MP0001873_stomach_inflammation0.68409666
117MP0003828_pulmonary_edema0.68139245
118MP0002877_abnormal_melanocyte_morpholog0.67426770
119MP0002166_altered_tumor_susceptibility0.65887923
120MP0009765_abnormal_xenobiotic_induced0.65755057
121MP0005666_abnormal_adipose_tissue0.65344261
122MP0001666_abnormal_nutrient_absorption0.65106653
123MP0003879_abnormal_hair_cell0.65096175
124MP0008874_decreased_physiological_sensi0.63107753
125MP0003786_premature_aging0.63079852
126MP0001542_abnormal_bone_strength0.62922403

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)9.20173728
2Poikilocytosis (HP:0004447)5.86029301
3Abnormality of glycolipid metabolism (HP:0010969)5.52559106
4Abnormality of liposaccharide metabolism (HP:0010968)5.52559106
5Abnormality of glycosphingolipid metabolism (HP:0004343)5.52559106
6Reticulocytosis (HP:0001923)4.99366482
7Abnormal number of erythroid precursors (HP:0012131)4.81816546
8Acanthocytosis (HP:0001927)4.74919525
9Abnormal hemoglobin (HP:0011902)4.73854619
10Abnormality of cells of the erythroid lineage (HP:0012130)4.56718427
11Recurrent gram-negative bacterial infections (HP:0005420)4.15457246
12Recurrent abscess formation (HP:0002722)4.02992841
13Abnormality of reticulocytes (HP:0004312)3.94136685
14Hyperbilirubinemia (HP:0002904)3.93805310
15Increased serum ferritin (HP:0003281)3.89865615
16Petechiae (HP:0000967)3.81428110
17Recurrent bacterial skin infections (HP:0005406)3.78367818
18Eczematoid dermatitis (HP:0000976)3.68832115
19Autoimmune thrombocytopenia (HP:0001973)3.67217453
20Abnormality of iron homeostasis (HP:0011031)3.58505596
21Nausea (HP:0002018)3.55258914
22Systemic lupus erythematosus (HP:0002725)3.53651851
23Paralysis (HP:0003470)3.36164498
24Cholelithiasis (HP:0001081)3.33928310
25Abnormality of transition element cation homeostasis (HP:0011030)3.23816462
26Hypochromic microcytic anemia (HP:0004840)3.23461029
27Cutaneous photosensitivity (HP:0000992)3.06934011
28Polycythemia (HP:0001901)3.06514788
29Dysostosis multiplex (HP:0000943)3.05486441
30Abnormal gallbladder morphology (HP:0012437)3.04585175
31Hypertensive crisis (HP:0100735)2.99175117
32Diaphragmatic weakness (HP:0009113)2.96738546
33Urticaria (HP:0001025)2.96106410
34Pustule (HP:0200039)2.87825037
35Abnormality of monocarboxylic acid metabolism (HP:0010996)2.87374725
36Joint hemorrhage (HP:0005261)2.84892543
37Microcytic anemia (HP:0001935)2.80107801
38Prolonged partial thromboplastin time (HP:0003645)2.76287117
39Hypochromic anemia (HP:0001931)2.75551761
40Abnormality of macrophages (HP:0004311)2.73246436
41Pallor (HP:0000980)2.72460202
42Chronic obstructive pulmonary disease (HP:0006510)2.71269438
43Prolonged bleeding time (HP:0003010)2.69686298
44Abnormality of pyrimidine metabolism (HP:0004353)2.66356785
45Hepatocellular carcinoma (HP:0001402)2.65068753
46Axonal loss (HP:0003447)2.64663636
47Xanthomatosis (HP:0000991)2.64290254
48Mediastinal lymphadenopathy (HP:0100721)2.60319106
49Epistaxis (HP:0000421)2.52857724
50Abnormality of aromatic amino acid family metabolism (HP:0004338)2.49727479
51Loss of speech (HP:0002371)2.49533128
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.43120752
53Abnormality of polysaccharide metabolism (HP:0011012)2.43120752
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.43120752
55Complement deficiency (HP:0004431)2.42146984
56Purpura (HP:0000979)2.38822106
57Recurrent skin infections (HP:0001581)2.37905326
58Abnormality of complement system (HP:0005339)2.37531571
59Vacuolated lymphocytes (HP:0001922)2.34814175
60Deep venous thrombosis (HP:0002625)2.31671851
61Glomerulonephritis (HP:0000099)2.30731619
62Poor head control (HP:0002421)2.29804882
63Intrahepatic cholestasis (HP:0001406)2.24500035
64Disinhibition (HP:0000734)2.24239323
65Hypobetalipoproteinemia (HP:0003563)2.23224882
66Cholecystitis (HP:0001082)2.21650702
67Abnormal gallbladder physiology (HP:0012438)2.21650702
68Macrocytic anemia (HP:0001972)2.21597050
69Progressive neurologic deterioration (HP:0002344)2.19040312
70Abnormality of the gallbladder (HP:0005264)2.17653604
71Mucopolysacchariduria (HP:0008155)2.16601167
72Urinary glycosaminoglycan excretion (HP:0003541)2.16601167
73Pathologic fracture (HP:0002756)2.16362830
74Ileus (HP:0002595)2.14622518
75Elevated erythrocyte sedimentation rate (HP:0003565)2.14273846
76Tetraparesis (HP:0002273)2.09937322
77Albinism (HP:0001022)2.09889058
78Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.08944152
79Gingival bleeding (HP:0000225)2.07070210
80Reticulocytopenia (HP:0001896)2.07061491
81Birth length less than 3rd percentile (HP:0003561)2.05934522
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.05030736
83Exertional dyspnea (HP:0002875)2.04972492
84Myocardial infarction (HP:0001658)2.03128358
85Gingivitis (HP:0000230)2.00209336
86Cerebral palsy (HP:0100021)1.98681861
87Nonimmune hydrops fetalis (HP:0001790)1.98000387
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96531999
89Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96531999
90Hepatosplenomegaly (HP:0001433)1.96152436
91Basal ganglia calcification (HP:0002135)1.95005152
92Increased cerebral lipofuscin (HP:0011813)1.94055506
93Hypercholesterolemia (HP:0003124)1.93749711
94Impaired platelet aggregation (HP:0003540)1.92658445
95Abnormal platelet function (HP:0011869)1.92658445
96Hyperthyroidism (HP:0000836)1.91614790
97Abnormality of the common coagulation pathway (HP:0010990)1.91515704
98Cardiomegaly (HP:0001640)1.89913786
99Short middle phalanx of the 5th finger (HP:0004220)1.88749057
100Prostate neoplasm (HP:0100787)1.88312253
101Vertebral compression fractures (HP:0002953)1.87082354
102Increased IgM level (HP:0003496)1.86594165
103Cellulitis (HP:0100658)1.86105567
104Multiple enchondromatosis (HP:0005701)1.85880427
105Increased muscle lipid content (HP:0009058)1.84892038
106Anorexia (HP:0002039)1.84665895
107Vasculitis (HP:0002633)1.83763549
108Splenomegaly (HP:0001744)1.83058650
109Hyperlipoproteinemia (HP:0010980)1.81943524
110Hyperammonemia (HP:0001987)1.81368569
111Recurrent viral infections (HP:0004429)1.80653231
112Abnormal mitochondria in muscle tissue (HP:0008316)1.80580499
113Nuclear cataract (HP:0100018)1.80315674
114Ragged-red muscle fibers (HP:0003200)1.79703635
115Osteomalacia (HP:0002749)1.79121282
116Prolonged neonatal jaundice (HP:0006579)1.79062416
117Mutism (HP:0002300)1.78325481
118Recurrent fungal infections (HP:0002841)1.78036305
119Lower limb hyperreflexia (HP:0002395)1.77623966
1203-Methylglutaconic aciduria (HP:0003535)1.77084051
121Toxemia of pregnancy (HP:0100603)1.75405884
122Acute encephalopathy (HP:0006846)1.75293891
123Hypertriglyceridemia (HP:0002155)1.74442561
124Myositis (HP:0100614)1.74377239
125Esophageal neoplasm (HP:0100751)1.73500478
126Neoplasm of head and neck (HP:0012288)1.73500478
127Reduced antithrombin III activity (HP:0001976)1.73439260
128Increased intramyocellular lipid droplets (HP:0012240)1.72489159
129Hepatic necrosis (HP:0002605)1.70606343
130Obstructive lung disease (HP:0006536)1.70519744
131Slow saccadic eye movements (HP:0000514)1.70287667
132Upper motor neuron abnormality (HP:0002127)1.69909998
133Spontaneous hematomas (HP:0007420)1.69381701
134Gastrointestinal infarctions (HP:0005244)1.68614203
135Hepatocellular necrosis (HP:0001404)1.68167838
136Seborrheic dermatitis (HP:0001051)1.67383837
137Stomatitis (HP:0010280)1.66874792

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.60146034
2NME24.39198051
3EIF2AK13.90804397
4PIM22.96759429
5PRPF4B2.69101258
6BLK2.59207862
7TBK12.56889050
8MAP3K142.48736688
9TYK22.44413264
10TLK12.27930830
11IRAK32.14751371
12IKBKB2.02108354
13STK42.01580920
14TESK21.98062432
15ERN11.93047674
16ABL21.89454543
17MAP3K111.87335229
18MAP4K11.83781968
19RIPK41.80956976
20MST41.77014051
21IKBKE1.74453057
22PIM11.62966504
23BUB11.60330072
24RPS6KA41.59529543
25IRAK41.57277437
26SCYL21.52997708
27MAP3K101.49649625
28TRIB31.46839005
29STK101.42971110
30MAP3K11.38572762
31TESK11.33617303
32NEK91.33518821
33KDR1.28004197
34JAK31.25195587
35VRK11.19812058
36MAP2K31.18485512
37BCKDK1.17962120
38JAK21.16596176
39MST1R1.15493608
40SYK1.15401903
41LYN1.11617713
42KIT1.08368460
43SMG11.07923156
44ZAK1.03844827
45CDC71.02423191
46NEK21.00561510
47BMPR20.99578493
48VRK20.97566450
49WEE10.95849356
50SIK10.92016210
51DYRK30.91826818
52MAP3K30.91131684
53ACVR1B0.91111664
54KSR20.89962653
55CHUK0.89882094
56RAF10.89136549
57ZAP700.88248875
58FGR0.88206014
59BMX0.88178807
60EIF2AK20.88046797
61LRRK20.87598530
62MAP3K20.85971563
63MAPK110.85968394
64TGFBR20.85693737
65TAOK30.85669486
66MAP3K120.84316698
67TNK20.80256786
68BTK0.77820368
69MAP3K80.77678166
70PAK40.76700577
71CDK40.76300984
72TRPM70.74540237
73JAK10.72239304
74MATK0.71997848
75BRSK20.71843712
76BRSK10.71105332
77STK160.70849059
78CDK60.69967135
79TAOK20.69130192
80TXK0.68685760
81NME10.67624092
82AURKA0.65829323
83FLT30.65351247
84ARAF0.64641564
85CSF1R0.63406699
86AURKB0.63017000
87MAP3K50.62689874
88RPS6KA50.61988474
89PDK20.61552006
90GRK60.60540014
91GRK70.60198634
92IRAK20.58625637
93PRKCD0.56307649
94CCNB10.53509802
95BRAF0.53339601
96ILK0.52481637
97PDPK10.51945855
98RPS6KC10.51569229
99RPS6KL10.51569229
100ICK0.51419083
101HIPK20.51130454
102TEC0.50899171
103MAPKAPK20.50439687
104ATR0.49458910
105MAP2K60.48801979
106PLK10.47797565
107CSNK2A10.47777289
108EIF2AK30.47740285
109CAMK1D0.46324396
110CSK0.45839556
111LCK0.45491353
112DAPK30.44681883
113MAPKAPK30.44675700
114PAK10.44197143
115MAP3K60.42334647
116CLK10.41272525
117RPS6KA60.41219455
118MARK30.40762149
119PTK60.40383343
120FES0.40234169
121CDK70.39566143
122DYRK1B0.38409717
123TAOK10.38264285
124MAP2K10.37042620
125MAP2K20.36865113
126SIK30.35664939
127MAPK120.35141522
128RPS6KB20.34822508
129EPHA20.34568787
130YES10.34266412
131ABL10.33680656
132HCK0.33570252
133IRAK10.32631967
134DAPK20.31380701
135EGFR0.31310393
136PRKG20.30967350
137PIK3CG0.30559959
138CSNK2A20.30207402
139PRKAA20.29604207
140KSR10.28657200

Predicted pathways (KEGG)

RankGene SetZ-score
1* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008604.22810700
2Ribosome_Homo sapiens_hsa030102.56749341
3Staphylococcus aureus infection_Homo sapiens_hsa051502.46574475
4DNA replication_Homo sapiens_hsa030302.39979928
5Proteasome_Homo sapiens_hsa030502.20420940
6Sulfur relay system_Homo sapiens_hsa041222.13077363
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09567151
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.09201176
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.06939658
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.04848107
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96240536
12Collecting duct acid secretion_Homo sapiens_hsa049661.84785840
13Complement and coagulation cascades_Homo sapiens_hsa046101.80672317
14Fructose and mannose metabolism_Homo sapiens_hsa000511.79868951
15One carbon pool by folate_Homo sapiens_hsa006701.70245926
16Legionellosis_Homo sapiens_hsa051341.66821082
17Leishmaniasis_Homo sapiens_hsa051401.66523945
18Caffeine metabolism_Homo sapiens_hsa002321.65058182
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57112969
20Graft-versus-host disease_Homo sapiens_hsa053321.56906755
21Folate biosynthesis_Homo sapiens_hsa007901.56099555
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.51555258
23Malaria_Homo sapiens_hsa051441.43989780
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.43919393
25Galactose metabolism_Homo sapiens_hsa000521.37619064
26Systemic lupus erythematosus_Homo sapiens_hsa053221.36465960
27Pyrimidine metabolism_Homo sapiens_hsa002401.35054720
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33720336
29Chemical carcinogenesis_Homo sapiens_hsa052041.32494326
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31508884
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29952150
32Acute myeloid leukemia_Homo sapiens_hsa052211.28429629
33Mismatch repair_Homo sapiens_hsa034301.28007591
34Peroxisome_Homo sapiens_hsa041461.27770377
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26022481
36Glutathione metabolism_Homo sapiens_hsa004801.21084600
37Selenocompound metabolism_Homo sapiens_hsa004501.18747318
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17379766
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16135674
40Pertussis_Homo sapiens_hsa051331.16004633
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14771154
42Base excision repair_Homo sapiens_hsa034101.13573460
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12822439
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.12190892
45Hematopoietic cell lineage_Homo sapiens_hsa046401.11595400
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09779934
47Herpes simplex infection_Homo sapiens_hsa051681.09494866
48Asthma_Homo sapiens_hsa053101.07953336
49Fatty acid elongation_Homo sapiens_hsa000621.07796203
50Allograft rejection_Homo sapiens_hsa053301.04522108
51Oxidative phosphorylation_Homo sapiens_hsa001901.04390114
52Pentose phosphate pathway_Homo sapiens_hsa000301.04349503
53Measles_Homo sapiens_hsa051621.02368557
54ABC transporters_Homo sapiens_hsa020101.02052691
55Tuberculosis_Homo sapiens_hsa051521.01791246
56Bladder cancer_Homo sapiens_hsa052191.00971159
57Arginine biosynthesis_Homo sapiens_hsa002201.00922340
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.97931267
59Homologous recombination_Homo sapiens_hsa034400.97516823
60Nucleotide excision repair_Homo sapiens_hsa034200.94682133
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93827626
62Prion diseases_Homo sapiens_hsa050200.93666366
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93324054
64Vitamin B6 metabolism_Homo sapiens_hsa007500.93080009
65Parkinsons disease_Homo sapiens_hsa050120.92982496
66Fatty acid degradation_Homo sapiens_hsa000710.92555720
67Tryptophan metabolism_Homo sapiens_hsa003800.91852189
68Apoptosis_Homo sapiens_hsa042100.91468138
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.88144718
70Retinol metabolism_Homo sapiens_hsa008300.88075528
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.85750880
72Influenza A_Homo sapiens_hsa051640.84843589
73beta-Alanine metabolism_Homo sapiens_hsa004100.84356925
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82347269
75Lysosome_Homo sapiens_hsa041420.82124916
76RNA polymerase_Homo sapiens_hsa030200.81618835
77Rheumatoid arthritis_Homo sapiens_hsa053230.81574414
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.81399762
79Osteoclast differentiation_Homo sapiens_hsa043800.79879486
80Histidine metabolism_Homo sapiens_hsa003400.77702872
81Vibrio cholerae infection_Homo sapiens_hsa051100.76303656
82Alzheimers disease_Homo sapiens_hsa050100.75919812
83PPAR signaling pathway_Homo sapiens_hsa033200.75528470
84Pyruvate metabolism_Homo sapiens_hsa006200.75134209
85B cell receptor signaling pathway_Homo sapiens_hsa046620.74705811
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73918939
87Phagosome_Homo sapiens_hsa041450.71263174
88Phenylalanine metabolism_Homo sapiens_hsa003600.68822956
89p53 signaling pathway_Homo sapiens_hsa041150.68653090
90Hepatitis C_Homo sapiens_hsa051600.67954347
91Sulfur metabolism_Homo sapiens_hsa009200.67581441
92Epstein-Barr virus infection_Homo sapiens_hsa051690.67483159
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66548737
94Shigellosis_Homo sapiens_hsa051310.66188714
95Antigen processing and presentation_Homo sapiens_hsa046120.64305599
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63621875
97TNF signaling pathway_Homo sapiens_hsa046680.58789812
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58579520
99Chronic myeloid leukemia_Homo sapiens_hsa052200.58221688
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58110214
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57558251
102Starch and sucrose metabolism_Homo sapiens_hsa005000.56936415
103Huntingtons disease_Homo sapiens_hsa050160.55577492
104Spliceosome_Homo sapiens_hsa030400.54386629
105Carbon metabolism_Homo sapiens_hsa012000.54106014
106Autoimmune thyroid disease_Homo sapiens_hsa053200.54090473
107Hepatitis B_Homo sapiens_hsa051610.54022063
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53696275
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53663118
110Mineral absorption_Homo sapiens_hsa049780.50298354
111N-Glycan biosynthesis_Homo sapiens_hsa005100.50074313
112Pancreatic cancer_Homo sapiens_hsa052120.49966209
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49335443
114Salmonella infection_Homo sapiens_hsa051320.48724811
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.48674567
116Steroid biosynthesis_Homo sapiens_hsa001000.48021918
117HIF-1 signaling pathway_Homo sapiens_hsa040660.47919490
118Biosynthesis of amino acids_Homo sapiens_hsa012300.46795888
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46777139
120Sphingolipid metabolism_Homo sapiens_hsa006000.46339015
121Toxoplasmosis_Homo sapiens_hsa051450.45709323
122Metabolic pathways_Homo sapiens_hsa011000.45646770
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45454211
124Non-small cell lung cancer_Homo sapiens_hsa052230.44984535
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.43419824
126African trypanosomiasis_Homo sapiens_hsa051430.43389345
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42702936
128Tyrosine metabolism_Homo sapiens_hsa003500.42365424
129Cell cycle_Homo sapiens_hsa041100.42242714
130Other glycan degradation_Homo sapiens_hsa005110.42082654
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41943379
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40309698

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