BLZF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)5.41747504
2fatty acid elongation (GO:0030497)4.96824072
3protein deneddylation (GO:0000338)4.86259880
4COPI coating of Golgi vesicle (GO:0048205)4.30575858
5Golgi transport vesicle coating (GO:0048200)4.30575858
6chondrocyte development (GO:0002063)4.06480412
7signal peptide processing (GO:0006465)4.04880292
8ER overload response (GO:0006983)3.79107005
9regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.78072064
10COPII vesicle coating (GO:0048208)3.65061486
11response to redox state (GO:0051775)3.48440727
12keratan sulfate catabolic process (GO:0042340)3.38164241
13photoreceptor cell differentiation (GO:0046530)3.35826825
14eye photoreceptor cell differentiation (GO:0001754)3.35826825
15cell wall macromolecule metabolic process (GO:0044036)3.35240213
16cell wall macromolecule catabolic process (GO:0016998)3.35240213
17interleukin-6-mediated signaling pathway (GO:0070102)3.31992754
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.31451327
19cellular response to interferon-alpha (GO:0035457)3.27006643
20positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.24957292
21cellular response to hepatocyte growth factor stimulus (GO:0035729)3.23747115
22response to hepatocyte growth factor (GO:0035728)3.23747115
23sphingosine metabolic process (GO:0006670)3.22730378
24nucleotide-sugar biosynthetic process (GO:0009226)3.19001586
25intraciliary transport (GO:0042073)3.15578692
26sphingoid metabolic process (GO:0046519)3.15286503
27regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.14704714
28regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.12128880
29ribosome assembly (GO:0042255)3.09928682
30rRNA methylation (GO:0031167)3.09047358
31fusion of sperm to egg plasma membrane (GO:0007342)3.08013511
32cell aggregation (GO:0098743)3.07860307
33cartilage condensation (GO:0001502)3.07860307
34spermatid nucleus differentiation (GO:0007289)3.06641928
35rRNA modification (GO:0000154)3.04956715
36positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.04538693
37regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.04538693
38positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.04020957
39detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.01413152
40multicellular organism reproduction (GO:0032504)2.95709095
41acrosome assembly (GO:0001675)2.94774284
42myelin assembly (GO:0032288)2.94592010
43regulation of acyl-CoA biosynthetic process (GO:0050812)2.94268603
44regulation of T-helper 1 cell differentiation (GO:0045625)2.93724328
45histone mRNA catabolic process (GO:0071044)2.92030770
46regulation of interleukin-8 biosynthetic process (GO:0045414)2.91963961
47prenylation (GO:0097354)2.91947898
48protein prenylation (GO:0018342)2.91947898
49regulation of chronic inflammatory response (GO:0002676)2.91848720
50platelet dense granule organization (GO:0060155)2.91330631
51protein neddylation (GO:0045116)2.89120678
52piRNA metabolic process (GO:0034587)2.88164478
53peroxisome fission (GO:0016559)2.87062550
54maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.85903513
55sperm-egg recognition (GO:0035036)2.85781116
56cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.85681996
57cell adhesion mediated by integrin (GO:0033627)2.84294763
58glycerophospholipid catabolic process (GO:0046475)2.84195333
59tRNA aminoacylation for protein translation (GO:0006418)2.84144571
60cholesterol biosynthetic process (GO:0006695)2.82227543
61positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.79959275
62negative regulation of mast cell activation (GO:0033004)2.79344886
63regulation of vitamin D biosynthetic process (GO:0060556)2.78861140
64proteasome assembly (GO:0043248)2.78213976
65amino acid activation (GO:0043038)2.76511523
66tRNA aminoacylation (GO:0043039)2.76511523
67diol metabolic process (GO:0034311)2.76089701
68long-chain fatty acid biosynthetic process (GO:0042759)2.76002951
69positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.74591802
70mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.74591802
71neutrophil activation involved in immune response (GO:0002283)2.74330886
72indole-containing compound catabolic process (GO:0042436)2.74043865
73indolalkylamine catabolic process (GO:0046218)2.74043865
74tryptophan catabolic process (GO:0006569)2.74043865
757-methylguanosine RNA capping (GO:0009452)2.73063194
76RNA capping (GO:0036260)2.73063194
77purine nucleobase biosynthetic process (GO:0009113)2.72789352
78DNA double-strand break processing (GO:0000729)2.72583357
79termination of RNA polymerase III transcription (GO:0006386)2.72472590
80transcription elongation from RNA polymerase III promoter (GO:0006385)2.72472590
817-methylguanosine mRNA capping (GO:0006370)2.72432586
82magnesium ion transport (GO:0015693)2.72162779
83regulation of cofactor metabolic process (GO:0051193)2.71441559
84regulation of coenzyme metabolic process (GO:0051196)2.71441559
85sterol biosynthetic process (GO:0016126)2.70681478
86peptidyl-histidine modification (GO:0018202)2.70318101
87binding of sperm to zona pellucida (GO:0007339)2.69934857
88tryptophan metabolic process (GO:0006568)2.69886814
89positive regulation of toll-like receptor signaling pathway (GO:0034123)2.67332104
90regulation of cilium movement (GO:0003352)2.67318304
91glycerol ether metabolic process (GO:0006662)2.66200620
92apical protein localization (GO:0045176)2.65757317
93intra-Golgi vesicle-mediated transport (GO:0006891)2.65451873
94regulation of meiosis I (GO:0060631)2.64009069
95long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.63917553
96L-methionine salvage (GO:0071267)2.63108678
97L-methionine biosynthetic process (GO:0071265)2.63108678
98amino acid salvage (GO:0043102)2.63108678
99synapsis (GO:0007129)2.62979096
100male meiosis (GO:0007140)2.62440084
101collagen fibril organization (GO:0030199)2.62170022
102N-terminal protein amino acid modification (GO:0031365)2.59062405
103negative regulation of neurotransmitter secretion (GO:0046929)2.59005482
104asymmetric protein localization (GO:0008105)2.58765003
105adenosine metabolic process (GO:0046085)2.58748650
106eosinophil chemotaxis (GO:0048245)2.58497045
107nucleoside diphosphate catabolic process (GO:0009134)2.57085586
108UDP-N-acetylglucosamine metabolic process (GO:0006047)2.55372022
109protein refolding (GO:0042026)2.54176680
110DNA replication-dependent nucleosome organization (GO:0034723)2.54004470
111DNA replication-dependent nucleosome assembly (GO:0006335)2.54004470
112regulation of spindle organization (GO:0090224)2.53782388
113long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.53381972
114regulation of interferon-alpha production (GO:0032647)2.53222493
115cellular response to gamma radiation (GO:0071480)2.53124894
116positive regulation of protein autophosphorylation (GO:0031954)2.52779575
117axon ensheathment in central nervous system (GO:0032291)2.52644092
118central nervous system myelination (GO:0022010)2.52644092
119regulation of hypersensitivity (GO:0002883)2.50286012
120natural killer cell activation involved in immune response (GO:0002323)2.49639852
121kynurenine metabolic process (GO:0070189)2.49281139
122establishment of protein localization to Golgi (GO:0072600)2.48732005
123protein targeting to Golgi (GO:0000042)2.48213721
124tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.48135430
125RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.48135430
126regulation of immunoglobulin secretion (GO:0051023)2.46945927
127ether lipid metabolic process (GO:0046485)2.46118254
128protein K63-linked deubiquitination (GO:0070536)2.44973899
129axonemal dynein complex assembly (GO:0070286)2.44672979
130branching involved in prostate gland morphogenesis (GO:0060442)2.44191420
131nucleobase biosynthetic process (GO:0046112)2.43662983
132regulation of metalloenzyme activity (GO:0048552)2.43319550
133IMP metabolic process (GO:0046040)2.43309899
134ER to Golgi vesicle-mediated transport (GO:0006888)2.42550121
135retinal metabolic process (GO:0042574)2.41234071
136nucleotide transmembrane transport (GO:1901679)2.40611808
137ATP hydrolysis coupled proton transport (GO:0015991)2.40524231
138energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.40524231
139transferrin transport (GO:0033572)2.39125963
140regulation of cell communication by electrical coupling (GO:0010649)2.38108249
141response to hydroperoxide (GO:0033194)2.38072138
142indolalkylamine metabolic process (GO:0006586)2.37463943
143negative regulation of DNA repair (GO:0045738)2.37337128
144nucleotide-sugar metabolic process (GO:0009225)2.35986544
145cell redox homeostasis (GO:0045454)2.35836940
146ferric iron transport (GO:0015682)2.35814471
147trivalent inorganic cation transport (GO:0072512)2.35814471
148protein maturation by protein folding (GO:0022417)2.35712689
149positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.35502586
150protein K11-linked deubiquitination (GO:0035871)2.35283673
151regulation of integrin-mediated signaling pathway (GO:2001044)2.33720067
152DNA methylation involved in gamete generation (GO:0043046)2.33289505
153ether metabolic process (GO:0018904)2.32462191
154positive regulation of mitochondrial fission (GO:0090141)2.32089397
155RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.31434224
156regulation of cytokine secretion involved in immune response (GO:0002739)2.31081983
157hepatocyte apoptotic process (GO:0097284)2.30607281
158regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.30365520
159cytokine biosynthetic process (GO:0042089)2.30342534
160negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.29537026
161regulation of MHC class I biosynthetic process (GO:0045343)2.28681834
162keratinocyte development (GO:0003334)2.28476735
163regulation of chemokine biosynthetic process (GO:0045073)2.27189623
164positive regulation of chemokine biosynthetic process (GO:0045080)2.26182803
165regulation of DNA endoreduplication (GO:0032875)2.25997068
166eosinophil migration (GO:0072677)2.25435958
167regulation of RIG-I signaling pathway (GO:0039535)2.25402151
168negative regulation of nitric oxide biosynthetic process (GO:0045019)2.23070857
169dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.23026056
170amine catabolic process (GO:0009310)2.21305419
171cellular biogenic amine catabolic process (GO:0042402)2.21305419
172positive regulation of response to biotic stimulus (GO:0002833)2.20323435
173DNA deamination (GO:0045006)2.20007987
174C-terminal protein lipidation (GO:0006501)2.19822584
175desmosome organization (GO:0002934)2.19506740
176retrograde transport, vesicle recycling within Golgi (GO:0000301)2.19324223
177regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.17921896
178cellular response to exogenous dsRNA (GO:0071360)2.17777478
179regulation of protein autophosphorylation (GO:0031952)2.17657752
180negative regulation of complement activation (GO:0045916)2.16729479
181negative regulation of cytokine secretion (GO:0050710)2.16340320
182positive regulation of interferon-beta production (GO:0032728)2.16268135
183retinal rod cell development (GO:0046548)2.15766059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.82253952
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.55865464
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.98981540
4* GABP_17652178_ChIP-ChIP_JURKAT_Human2.82011796
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.80786587
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71850030
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.52375395
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50564165
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43769886
10* EST1_17652178_ChIP-ChIP_JURKAT_Human2.36105049
11* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31886296
12PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29817806
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.26111618
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21654181
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.15635059
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.13459224
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.10711481
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.10427113
19* ELK1_19687146_ChIP-ChIP_HELA_Human2.08315548
20FUS_26573619_Chip-Seq_HEK293_Human2.07139657
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01669796
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01197828
23GBX2_23144817_ChIP-Seq_PC3_Human1.97069234
24AR_21909140_ChIP-Seq_LNCAP_Human1.94641657
25TAF15_26573619_Chip-Seq_HEK293_Human1.88429731
26* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.84736835
27* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84330314
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82929268
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79278897
30GATA1_22025678_ChIP-Seq_K562_Human1.78954116
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.75200050
32IGF1R_20145208_ChIP-Seq_DFB_Human1.75133285
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.74037153
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69548956
35* ETS1_20019798_ChIP-Seq_JURKAT_Human1.68986382
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.68882361
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66037767
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63908852
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62262708
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61554170
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60471963
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57737459
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.57250846
44DCP1A_22483619_ChIP-Seq_HELA_Human1.54418967
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.54348402
46ER_23166858_ChIP-Seq_MCF-7_Human1.54284198
47CJUN_26792858_Chip-Seq_BT549_Human1.53843332
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51611331
49* VDR_23849224_ChIP-Seq_CD4+_Human1.50259414
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50075284
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48651264
52BRD4_25478319_ChIP-Seq_HGPS_Human1.47866105
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47663702
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47397471
55CDX2_22108803_ChIP-Seq_LS180_Human1.44707927
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43534205
57EWS_26573619_Chip-Seq_HEK293_Human1.43507429
58* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39838454
59* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.39733848
60P300_19829295_ChIP-Seq_ESCs_Human1.36975968
61PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36217876
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36097706
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34285655
64* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34013807
65* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31926154
66* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31926154
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31191426
68* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29599164
69* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28058612
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27967756
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27234109
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.26837495
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24257967
74E2F7_22180533_ChIP-Seq_HELA_Human1.23767181
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23377673
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22710086
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22474479
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22404428
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19366908
80SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19298129
81JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19219474
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.18870630
83SALL4_22934838_ChIP-ChIP_CD34+_Human1.18589187
84* NANOG_18555785_Chip-Seq_ESCs_Mouse1.18409933
85IRF1_19129219_ChIP-ChIP_H3396_Human1.16057590
86VDR_22108803_ChIP-Seq_LS180_Human1.14493443
87SOX17_20123909_ChIP-Seq_XEN_Mouse1.14345750
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.13883493
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13599290
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.13322060
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12162203
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10967777
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10967777
94* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09429238
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08992900
96* CMYC_18555785_Chip-Seq_ESCs_Mouse1.07510245
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07494108
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07457674
99* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07423646
100* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07372511
101CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07084043
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06778360
103ELF5_23300383_ChIP-Seq_T47D_Human1.06461131
104SMAD4_21799915_ChIP-Seq_A2780_Human1.06068164
105* NMYC_18555785_Chip-Seq_ESCs_Mouse1.06028708
106CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05911444
107* P53_22387025_ChIP-Seq_ESCs_Mouse1.04826040
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04652661
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04237991
110* GATA3_26560356_Chip-Seq_TH2_Human1.03895197
111* OCT4_18555785_Chip-Seq_ESCs_Mouse1.03653923
112TP63_23658742_ChIP-Seq_EP156T_Human1.03482439
113SOX2_19829295_ChIP-Seq_ESCs_Human1.03435276
114NANOG_19829295_ChIP-Seq_ESCs_Human1.03435276
115E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03329631
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02904786
117* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02035257
118* STAT3_18555785_Chip-Seq_ESCs_Mouse1.01162016
119TRIM28_21343339_ChIP-Seq_HEK293_Human1.00144707
120ZNF274_21170338_ChIP-Seq_K562_Hela0.99419775
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98436781
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98281980
123MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97717533
124* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97169321
125* E2F1_18555785_Chip-Seq_ESCs_Mouse0.96108752
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95453752
127CBP_20019798_ChIP-Seq_JUKART_Human0.95453752
128* P300_18555785_Chip-Seq_ESCs_Mouse0.94287762
129ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94012187
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93627419
131TFEB_21752829_ChIP-Seq_HELA_Human0.92988085
132* SOX2_18555785_Chip-Seq_ESCs_Mouse0.92782398
133* CRX_20693478_ChIP-Seq_RETINA_Mouse0.92549174
134REST_19997604_ChIP-ChIP_NEURONS_Mouse0.92084187
135* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89673327
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89672785
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88560703
138PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88463065
139GABP_19822575_ChIP-Seq_HepG2_Human0.87661261

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane4.68657426
2MP0008438_abnormal_cutaneous_collagen3.66972156
3MP0000569_abnormal_digit_pigmentation3.07878643
4MP0003806_abnormal_nucleotide_metabolis3.03811173
5MP0010234_abnormal_vibrissa_follicle2.84467558
6MP0005275_abnormal_skin_tensile2.72541448
7MP0004134_abnormal_chest_morphology2.70054525
8MP0000749_muscle_degeneration2.60193901
9MP0000566_synostosis2.53011663
10MP0005503_abnormal_tendon_morphology2.37983807
11MP0003724_increased_susceptibility_to2.36571336
12MP0006054_spinal_hemorrhage2.31430824
13MP0005410_abnormal_fertilization2.30834566
14MP0009697_abnormal_copulation2.29839504
15MP0003646_muscle_fatigue2.26728745
16MP0005171_absent_coat_pigmentation2.24303377
17MP0002837_dystrophic_cardiac_calcinosis2.22946602
18MP0002148_abnormal_hypersensitivity_rea2.17616493
19MP0004272_abnormal_basement_membrane2.07732780
20MP0009785_altered_susceptibility_to2.07262912
21MP0002332_abnormal_exercise_endurance2.03517793
22MP0004036_abnormal_muscle_relaxation1.93556271
23MP0009780_abnormal_chondrocyte_physiolo1.92321469
24MP0008877_abnormal_DNA_methylation1.84495937
25MP0005464_abnormal_platelet_physiology1.83369105
26MP0004084_abnormal_cardiac_muscle1.82123671
27MP0006082_CNS_inflammation1.78724433
28MP0003693_abnormal_embryo_hatching1.78559601
29MP0003303_peritoneal_inflammation1.78333110
30MP0001299_abnormal_eye_distance/1.73066336
31MP0004957_abnormal_blastocyst_morpholog1.71542195
32MP0004145_abnormal_muscle_electrophysio1.62933346
33MP0000427_abnormal_hair_cycle1.59848564
34MP0000372_irregular_coat_pigmentation1.58435743
35MP0002877_abnormal_melanocyte_morpholog1.57903665
36MP0001661_extended_life_span1.57482451
37MP0003123_paternal_imprinting1.55675731
38MP0004043_abnormal_pH_regulation1.54208798
39MP0008057_abnormal_DNA_replication1.47497607
40MP0009764_decreased_sensitivity_to1.47290436
41MP0004147_increased_porphyrin_level1.47159528
42MP0000015_abnormal_ear_pigmentation1.44303343
43MP0003252_abnormal_bile_duct1.43969883
44MP0005360_urolithiasis1.42001729
45MP0002933_joint_inflammation1.38214703
46MP0003195_calcinosis1.38121124
47MP0008932_abnormal_embryonic_tissue1.38076909
48MP0001542_abnormal_bone_strength1.37567233
49MP0010352_gastrointestinal_tract_polyps1.35955176
50MP0003718_maternal_effect1.33535029
51MP0000383_abnormal_hair_follicle1.33346916
52MP0003656_abnormal_erythrocyte_physiolo1.32654173
53MP0000647_abnormal_sebaceous_gland1.32427611
54MP0002282_abnormal_trachea_morphology1.32297203
55MP0001191_abnormal_skin_condition1.31321658
56MP0005330_cardiomyopathy1.31025902
57MP0005164_abnormal_response_to1.30573600
58MP0000465_gastrointestinal_hemorrhage1.29660526
59MP0001216_abnormal_epidermal_layer1.28354053
60MP0002295_abnormal_pulmonary_circulatio1.27987975
61MP0003941_abnormal_skin_development1.25465955
62MP0002269_muscular_atrophy1.25177708
63MP0008004_abnormal_stomach_pH1.23541254
64MP0001764_abnormal_homeostasis1.23341870
65MP0003221_abnormal_cardiomyocyte_apopto1.23051720
66MP0010094_abnormal_chromosome_stability1.22569098
67MP0002108_abnormal_muscle_morphology1.21601118
68MP0003300_gastrointestinal_ulcer1.21070254
69MP0000163_abnormal_cartilage_morphology1.20732600
70MP0002006_tumorigenesis1.19203731
71MP0003183_abnormal_peptide_metabolism1.17981339
72MP0005623_abnormal_meninges_morphology1.17276636
73MP0001835_abnormal_antigen_presentation1.14229459
74MP0002166_altered_tumor_susceptibility1.13644929
75MP0004197_abnormal_fetal_growth/weight/1.13549831
76MP0000343_altered_response_to1.12913445
77MP0002095_abnormal_skin_pigmentation1.12562128
78MP0002060_abnormal_skin_morphology1.11949044
79MP0002796_impaired_skin_barrier1.11754748
80MP0003191_abnormal_cellular_cholesterol1.10882640
81MP0002876_abnormal_thyroid_physiology1.10337325
82MP0003786_premature_aging1.08901361
83MP0006072_abnormal_retinal_apoptosis1.08511885
84MP0000920_abnormal_myelination1.08506461
85MP0000013_abnormal_adipose_tissue1.08058004
86MP0000751_myopathy1.07860143
87MP0008775_abnormal_heart_ventricle1.07630720
88MP0005551_abnormal_eye_electrophysiolog1.07204104
89MP0005000_abnormal_immune_tolerance1.07173978
90MP0010678_abnormal_skin_adnexa1.06617306
91MP0001845_abnormal_inflammatory_respons1.05043987
92MP0000371_diluted_coat_color1.05011409
93MP0001929_abnormal_gametogenesis1.04691192
94MP0004215_abnormal_myocardial_fiber1.04281859
95MP0000358_abnormal_cell_content/1.03997147
96MP0004233_abnormal_muscle_weight1.03315302
97MP0005174_abnormal_tail_pigmentation1.02844626
98MP0003937_abnormal_limbs/digits/tail_de1.02023453
99MP0008007_abnormal_cellular_replicative1.01940497
100MP0003186_abnormal_redox_activity1.01714311
101MP0000747_muscle_weakness1.01163135
102MP0000462_abnormal_digestive_system1.01158757
103MP0005395_other_phenotype0.99809168
104MP0000762_abnormal_tongue_morphology0.99028955
105MP0002009_preneoplasia0.98757295
106MP0004484_altered_response_of0.98740176
107MP0005508_abnormal_skeleton_morphology0.98274843
108MP0003448_altered_tumor_morphology0.97727672
109MP0003453_abnormal_keratinocyte_physiol0.97112547
110MP0005408_hypopigmentation0.94811162
111MP0009384_cardiac_valve_regurgitation0.93343055
112MP0005501_abnormal_skin_physiology0.93064794
113MP0010386_abnormal_urinary_bladder0.92794812
114MP0005647_abnormal_sex_gland0.91911195
115MP0003121_genomic_imprinting0.91620785
116MP0005387_immune_system_phenotype0.91582544
117MP0001790_abnormal_immune_system0.91582544
118MP0006035_abnormal_mitochondrial_morpho0.90538148
119MP0001188_hyperpigmentation0.89869164
120MP0002115_abnormal_skeleton_extremities0.89506671
121MP0001485_abnormal_pinna_reflex0.86273822
122MP0002168_other_aberrant_phenotype0.86041691
123MP0003868_abnormal_feces_composition0.85791009
124MP0005620_abnormal_muscle_contractility0.85465424
125MP0009763_increased_sensitivity_to0.85282266
126MP0008875_abnormal_xenobiotic_pharmacok0.84842003
127MP0010155_abnormal_intestine_physiology0.84412229
128MP0005253_abnormal_eye_physiology0.83933631
129MP0005389_reproductive_system_phenotype0.83081139
130MP0003077_abnormal_cell_cycle0.82998519
131MP0003698_abnormal_male_reproductive0.82648803
132MP0005376_homeostasis/metabolism_phenot0.82633961
133MP0001177_atelectasis0.82118409
134MP0010771_integument_phenotype0.81412653
135MP0008469_abnormal_protein_level0.80504598
136MP0002452_abnormal_antigen_presenting0.80009105
137MP0001853_heart_inflammation0.79740422
138MP0002972_abnormal_cardiac_muscle0.79607687
139MP0006036_abnormal_mitochondrial_physio0.77353557
140MP0004883_abnormal_blood_vessel0.76681986
141MP0002723_abnormal_immune_serum0.76486198
142MP0001919_abnormal_reproductive_system0.76259600
143MP0005165_increased_susceptibility_to0.75577715
144MP0005023_abnormal_wound_healing0.75168351
145MP0005084_abnormal_gallbladder_morpholo0.74482037
146MP0008873_increased_physiological_sensi0.73930678
147MP0002210_abnormal_sex_determination0.73822840
148MP0003566_abnormal_cell_adhesion0.72725624
149MP0002127_abnormal_cardiovascular_syste0.72201301
150MP0005369_muscle_phenotype0.72184789
151MP0005266_abnormal_metabolism0.70218852
152MP0008058_abnormal_DNA_repair0.69567594
153MP0009250_abnormal_appendicular_skeleto0.69405115
154MP0003755_abnormal_palate_morphology0.68810583
155MP0001730_embryonic_growth_arrest0.67628379
156MP0001145_abnormal_male_reproductive0.66345025
157MP0002896_abnormal_bone_mineralization0.66331261
158MP0001697_abnormal_embryo_size0.62943119
159MP0001243_abnormal_dermal_layer0.62938596

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)7.34380304
2Epiphyseal dysplasia (HP:0002656)5.70466778
3Vitreoretinal degeneration (HP:0000655)5.60127174
4Hypoplastic ischia (HP:0003175)4.79453012
5Small epiphyses (HP:0010585)4.51014694
6Abnormality of the ischium (HP:0003174)4.31350430
7Increased serum pyruvate (HP:0003542)4.08728358
8Abnormality of glycolysis (HP:0004366)4.08728358
9Absent epiphyses (HP:0010577)3.90129070
10Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.90129070
11Flat capital femoral epiphysis (HP:0003370)3.65625250
12Cupped ribs (HP:0000887)3.61662638
13Follicular hyperkeratosis (HP:0007502)3.31620531
14Autoimmune hemolytic anemia (HP:0001890)3.26342052
15Abnormality of the vertebral endplates (HP:0005106)3.25955404
16Mild short stature (HP:0003502)3.22498553
17Abnormality of femoral epiphyses (HP:0006499)3.19376470
18Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.19376470
19Flattened epiphyses (HP:0003071)3.14844252
20Delayed epiphyseal ossification (HP:0002663)3.12178316
21Irregular vertebral endplates (HP:0003301)3.10000984
22Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.08779672
23Protuberant abdomen (HP:0001538)3.06781629
24Abnormal tarsal ossification (HP:0008369)3.04298088
25Barrel-shaped chest (HP:0001552)3.01808174
26Azoospermia (HP:0000027)2.95939439
27Fair hair (HP:0002286)2.90926984
28Abnormality of the epiphysis of the femoral head (HP:0010574)2.90342617
29Abnormality of the femoral head (HP:0003368)2.88731489
30Fibular hypoplasia (HP:0003038)2.88506582
31Abnormality of incisor morphology (HP:0011063)2.87944396
32Genu varum (HP:0002970)2.87669817
33Short femoral neck (HP:0100864)2.82065977
34Abnormal spermatogenesis (HP:0008669)2.76710441
35Autoamputation (HP:0001218)2.75451317
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.75210848
37Hypoplastic pelvis (HP:0008839)2.69589632
38Vacuolated lymphocytes (HP:0001922)2.69288588
39Loss of speech (HP:0002371)2.69046592
40Osteoarthritis (HP:0002758)2.68107152
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.66380079
42Abnormality of alanine metabolism (HP:0010916)2.66380079
43Hyperalaninemia (HP:0003348)2.66380079
44Arthropathy (HP:0003040)2.66306042
45Thick nail (HP:0001805)2.61615903
46Abnormal foot bone ossification (HP:0010675)2.60144179
47Hypoplasia of the capital femoral epiphysis (HP:0003090)2.59768363
48Albinism (HP:0001022)2.56907783
49Dyschromatopsia (HP:0007641)2.56112762
50Metaphyseal dysplasia (HP:0100255)2.55678411
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51109757
52Abnormal protein N-linked glycosylation (HP:0012347)2.51109757
53Abnormal protein glycosylation (HP:0012346)2.51109757
54Abnormal glycosylation (HP:0012345)2.51109757
55Abnormality of the phalanges of the 2nd finger (HP:0009541)2.50388557
56Abnormality of the renal cortex (HP:0011035)2.44183087
57Cervical subluxation (HP:0003308)2.43985946
58Flat acetabular roof (HP:0003180)2.43626650
59Metaphyseal cupping (HP:0003021)2.42946878
60Relative macrocephaly (HP:0004482)2.39351669
61Disproportionate short-trunk short stature (HP:0003521)2.38815673
62Parakeratosis (HP:0001036)2.34737634
63Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.32457247
64Type I transferrin isoform profile (HP:0003642)2.32087771
65Hypoplasia of the odontoid process (HP:0003311)2.31943934
66Abnormality of methionine metabolism (HP:0010901)2.31940171
67Carpal bone hypoplasia (HP:0001498)2.30495925
68Generalized aminoaciduria (HP:0002909)2.29502621
69Stillbirth (HP:0003826)2.28928805
70Generalized hypopigmentation of hair (HP:0011358)2.27495040
71Patent foramen ovale (HP:0001655)2.27368003
72Onycholysis (HP:0001806)2.25717447
73Renal cortical cysts (HP:0000803)2.25706525
74Petechiae (HP:0000967)2.25369065
75Ectropion (HP:0000656)2.23909662
76Pancreatic cysts (HP:0001737)2.22708998
77Sensory axonal neuropathy (HP:0003390)2.20347788
78Degeneration of the lateral corticospinal tracts (HP:0002314)2.18722504
79Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.18722504
80Increased mean platelet volume (HP:0011877)2.17735073
81Exercise-induced muscle cramps (HP:0003710)2.14517474
82Thyroiditis (HP:0100646)2.14220275
83Hypothermia (HP:0002045)2.13160321
84Curly hair (HP:0002212)2.12917429
85Palmoplantar hyperkeratosis (HP:0000972)2.12064732
86Birth length less than 3rd percentile (HP:0003561)2.11113072
87Palmar hyperkeratosis (HP:0010765)2.10932246
88Aplasia/Hypoplasia of the fibula (HP:0006492)2.10735308
89Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10678816
90Tetraparesis (HP:0002273)2.09828337
91Hypokinesia (HP:0002375)2.09702841
92Plantar hyperkeratosis (HP:0007556)2.08849704
93Abnormality of the proximal phalanges of the hand (HP:0009834)2.06778355
94Premature rupture of membranes (HP:0001788)2.05800823
95Abnormality of macular pigmentation (HP:0008002)2.05690132
96Beaking of vertebral bodies (HP:0004568)2.05009309
97Papillary thyroid carcinoma (HP:0002895)2.04539910
98Spondylolisthesis (HP:0003302)2.02861254
99Horizontal nystagmus (HP:0000666)2.02745569
100Erythema (HP:0010783)2.01664349
101Platyspondyly (HP:0000926)2.01496922
102Medial flaring of the eyebrow (HP:0010747)2.01254466
103Abnormality of the vitreous humor (HP:0004327)1.99178132
104Congenital, generalized hypertrichosis (HP:0004540)1.98133886
105Postnatal microcephaly (HP:0005484)1.97484273
106Patchy hypopigmentation of hair (HP:0011365)1.96496286
107Abnormality of glycolipid metabolism (HP:0010969)1.95824810
108Abnormality of liposaccharide metabolism (HP:0010968)1.95824810
109Abnormality of glycosphingolipid metabolism (HP:0004343)1.95824810
110Sparse eyelashes (HP:0000653)1.94501251
111Abnormality of chromosome stability (HP:0003220)1.93999292
112Aplasia/hypoplasia of the femur (HP:0005613)1.92977865
113Neonatal respiratory distress (HP:0002643)1.92959806
114Chorioretinal atrophy (HP:0000533)1.92944391
115Eosinophilia (HP:0001880)1.91023698
116Coxa vara (HP:0002812)1.90838704
117Bell-shaped thorax (HP:0001591)1.89296566
118Widely spaced teeth (HP:0000687)1.89207293
119Alopecia of scalp (HP:0002293)1.88735840
120Submucous cleft hard palate (HP:0000176)1.88341770
121Stomatitis (HP:0010280)1.87311327
122Thoracolumbar scoliosis (HP:0002944)1.86694232
123Reduced antithrombin III activity (HP:0001976)1.86612776
124Thyroid carcinoma (HP:0002890)1.85926178
125Abnormality of secondary sexual hair (HP:0009888)1.85733984
126Abnormality of the axillary hair (HP:0100134)1.85733984
127True hermaphroditism (HP:0010459)1.85589801
128Anhidrosis (HP:0000970)1.85447866
129Congenital ichthyosiform erythroderma (HP:0007431)1.85304014
130Abnormal biliary tract physiology (HP:0012439)1.84976452
131Bile duct proliferation (HP:0001408)1.84976452
132Prolonged bleeding time (HP:0003010)1.84690336
133Tongue fasciculations (HP:0001308)1.83786572
134Gonadotropin excess (HP:0000837)1.83214422
135Nausea (HP:0002018)1.82009269
136Abnormality of the basal ganglia (HP:0002134)1.81673268
137Absent speech (HP:0001344)1.81625416
138Glossoptosis (HP:0000162)1.79432736
139Autoimmune thrombocytopenia (HP:0001973)1.78944786
140Periodontitis (HP:0000704)1.78573119
141Proximal tubulopathy (HP:0000114)1.78002417
142Degeneration of anterior horn cells (HP:0002398)1.77954130
143Abnormality of the anterior horn cell (HP:0006802)1.77954130
144Congenital primary aphakia (HP:0007707)1.76886772
145Hypoplasia of the uterus (HP:0000013)1.76859976
146Abnormality of dentin (HP:0010299)1.76725419
147Steatorrhea (HP:0002570)1.76689294
148Central scotoma (HP:0000603)1.76487456
149Abnormality of the labia minora (HP:0012880)1.75959818
150Metaphyseal irregularity (HP:0003025)1.75107876
151Insulin-resistant diabetes mellitus (HP:0000831)1.74796252
152Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.74499062
153Exocrine pancreatic insufficiency (HP:0001738)1.73616776
154Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.71833223
155Cerebral hypomyelination (HP:0006808)1.71709372
156Short middle phalanx of the 5th finger (HP:0004220)1.71321276
157Abnormal platelet volume (HP:0011876)1.71315276
158Nephrogenic diabetes insipidus (HP:0009806)1.71081100
159Abnormality of the odontoid process (HP:0003310)1.70997993
160Erythroderma (HP:0001019)1.70160758
161Ureteral duplication (HP:0000073)1.70072271
162Glucose intolerance (HP:0000833)1.69526410
163Methylmalonic acidemia (HP:0002912)1.69321561
164Abnormality of eosinophils (HP:0001879)1.68916337
165Prostate neoplasm (HP:0100787)1.68632109
166Neonatal short-limb short stature (HP:0008921)1.68543800
167Stenosis of the external auditory canal (HP:0000402)1.68394195
168Long clavicles (HP:0000890)1.68049518
169Abnormal auditory evoked potentials (HP:0006958)1.67664319
170Hematochezia (HP:0002573)1.65691319
171Muscle fiber splitting (HP:0003555)1.65600693
172Abnormality of the renal medulla (HP:0100957)1.65592599
173Freckling (HP:0001480)1.65581549
174Abnormal vertebral ossification (HP:0100569)1.65564429
175Pancreatic fibrosis (HP:0100732)1.65460700
176Posterior subcapsular cataract (HP:0007787)1.64971232
177Progressive inability to walk (HP:0002505)1.64124250
178Waddling gait (HP:0002515)1.63544324
179Gait imbalance (HP:0002141)1.63395013
180Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.63079900
181Hypoplasia of the fovea (HP:0007750)1.62610074
182Aplasia/Hypoplasia of the fovea (HP:0008060)1.62610074
183Cone-rod dystrophy (HP:0000548)1.62381999
184Acute necrotizing encephalopathy (HP:0006965)1.61869926
185Hypoplastic labia majora (HP:0000059)1.60950926
186Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.58277252
187Genital tract atresia (HP:0001827)1.58264227

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.75343493
2PDK33.61577398
3PDK43.61577398
4MST43.32607107
5STK393.30180027
6PDK22.99324844
7PBK2.97626719
8CASK2.65825102
9TRIM282.54565604
10STK38L2.32681926
11ZAK2.32106578
12MAP3K122.30121681
13BMPR22.14110054
14EIF2AK12.12735428
15FRK2.10926952
16MET2.10814384
17PIK3CA2.10063020
18OXSR12.06995860
19LIMK11.91299602
20BCR1.86270747
21EIF2AK31.83623596
22BUB11.82621739
23BMPR1B1.74116681
24STK161.68731148
25TSSK61.66657339
26NEK61.63001797
27WNK41.58400824
28MAP3K31.57467726
29PLK21.53222910
30ERBB41.51545232
31TAOK31.42920168
32EPHA21.42395860
33NEK91.34085193
34MAP3K141.33432358
35STK241.32705098
36ACVR1B1.25446253
37IKBKB1.21137642
38NME11.19689653
39EPHA31.17138853
40PLK31.16120248
41BRSK21.16084331
42TEC1.11523346
43VRK11.11497634
44MAP4K21.09864511
45MYLK1.06854270
46WEE11.05702275
47PLK41.05130828
48LATS11.02826192
49TTK1.01137982
50FLT31.00979098
51SRPK10.99168132
52OBSCN0.96881418
53TGFBR20.96246071
54EIF2AK20.95666319
55DDR20.95135242
56MKNK20.94843561
57PIM20.94673754
58SIK30.94096569
59IRAK20.93377581
60GRK70.90804064
61FER0.90133585
62TXK0.89541811
63PIK3CG0.89090170
64FGFR20.86816472
65NUAK10.86291239
66STK380.86068336
67IKBKE0.82973740
68WNK30.82710986
69MST1R0.81676605
70ERBB30.78294392
71MKNK10.76282581
72ADRBK20.76037853
73INSRR0.74719857
74LMTK20.72045372
75STK30.71787687
76IRAK10.71447963
77IRAK30.69554673
78TBK10.68383692
79TRPM70.67235023
80TESK10.66710924
81IRAK40.65760883
82SCYL20.65642998
83MAP3K50.65245336
84PRKCI0.63228636
85ABL20.62598213
86PTK2B0.62246513
87JAK10.61519906
88SGK2230.61287330
89SGK4940.61287330
90YES10.57325090
91BRD40.56110556
92CLK10.55073666
93BRAF0.54855145
94TAOK20.54288027
95ABL10.53602463
96BCKDK0.52200828
97CSNK1A1L0.51211877
98GRK10.50948192
99TLK10.50810923
100MARK30.49806448
101PASK0.49504012
102JAK30.49158993
103MELK0.48830749
104RPS6KB20.48188708
105MAP3K40.47949750
106EGFR0.47891365
107STK100.45491009
108CSNK1G30.44742828
109EPHB10.44369777
110TNIK0.43555311
111WNK10.43262312
112IGF1R0.43120797
113PRKCE0.42274750
114PKN10.41922227
115CAMK2D0.41704002
116RPS6KA50.40666842
117PAK30.40552365
118CHEK20.40271128
119CDK190.40094457
120ILK0.39374337
121SGK20.38725823
122KSR10.37979855
123ROCK10.37515832
124CSNK1G10.37059623
125CCNB10.36730022
126ATR0.36388005
127PLK10.34907587
128AURKA0.34377697
129RPS6KB10.34175149
130TGFBR10.33987366
131PAK40.32941862
132ROCK20.32645652
133PAK10.32500454
134CDC70.32156351
135AURKB0.32114496
136CSNK1G20.32012570
137MUSK0.31931753
138MAPKAPK30.29600752
139NEK10.26920767
140MAP3K20.26457126
141ADRBK10.26431805
142CHEK10.24331329
143MAP3K80.24239485
144ATM0.24147562
145TTN0.24116823

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.31443400
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.15165765
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.06960032
4Proteasome_Homo sapiens_hsa030502.95729063
5Non-homologous end-joining_Homo sapiens_hsa034502.76715321
6RNA polymerase_Homo sapiens_hsa030202.63233534
7Fatty acid elongation_Homo sapiens_hsa000622.48825626
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39318116
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.28900896
10Vibrio cholerae infection_Homo sapiens_hsa051102.19732858
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.18368647
12Basal transcription factors_Homo sapiens_hsa030222.15716833
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.13273105
14Sulfur metabolism_Homo sapiens_hsa009202.05291294
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.92103035
16Steroid biosynthesis_Homo sapiens_hsa001001.90672107
17Collecting duct acid secretion_Homo sapiens_hsa049661.87118103
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.79601999
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74629102
20Sphingolipid metabolism_Homo sapiens_hsa006001.69151512
21Oxidative phosphorylation_Homo sapiens_hsa001901.60783014
22Pyruvate metabolism_Homo sapiens_hsa006201.56574996
23Nucleotide excision repair_Homo sapiens_hsa034201.56098128
24ECM-receptor interaction_Homo sapiens_hsa045121.54380440
25Caffeine metabolism_Homo sapiens_hsa002321.53687569
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49672458
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.47309641
28Systemic lupus erythematosus_Homo sapiens_hsa053221.46012503
29Propanoate metabolism_Homo sapiens_hsa006401.45078807
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44352769
31Homologous recombination_Homo sapiens_hsa034401.41463013
32African trypanosomiasis_Homo sapiens_hsa051431.41066734
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34106793
34Ether lipid metabolism_Homo sapiens_hsa005651.33656027
35Selenocompound metabolism_Homo sapiens_hsa004501.32450279
36Measles_Homo sapiens_hsa051621.29907828
37RNA transport_Homo sapiens_hsa030131.29795019
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28975407
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28086620
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26744602
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26247378
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.26036458
43p53 signaling pathway_Homo sapiens_hsa041151.21568863
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21136376
45Linoleic acid metabolism_Homo sapiens_hsa005911.18000816
46TNF signaling pathway_Homo sapiens_hsa046681.17333465
47Purine metabolism_Homo sapiens_hsa002301.16437825
48Tryptophan metabolism_Homo sapiens_hsa003801.15321662
49Phagosome_Homo sapiens_hsa041451.11596608
50Vitamin B6 metabolism_Homo sapiens_hsa007501.11114643
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08640667
52Shigellosis_Homo sapiens_hsa051311.08382328
53Arachidonic acid metabolism_Homo sapiens_hsa005901.07190122
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.06822356
55RNA degradation_Homo sapiens_hsa030181.06049407
56Cell cycle_Homo sapiens_hsa041101.05636984
57Nitrogen metabolism_Homo sapiens_hsa009101.03731080
58Protein digestion and absorption_Homo sapiens_hsa049741.03439990
59One carbon pool by folate_Homo sapiens_hsa006701.00107363
60Folate biosynthesis_Homo sapiens_hsa007900.99858957
61Mineral absorption_Homo sapiens_hsa049780.99301024
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99260359
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.98551246
64Pyrimidine metabolism_Homo sapiens_hsa002400.97079501
65Lysosome_Homo sapiens_hsa041420.96523183
66Carbon metabolism_Homo sapiens_hsa012000.95791741
67Pentose phosphate pathway_Homo sapiens_hsa000300.95080169
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93700959
69Fatty acid metabolism_Homo sapiens_hsa012120.92957530
70Regulation of autophagy_Homo sapiens_hsa041400.92723316
71Huntingtons disease_Homo sapiens_hsa050160.92075669
72Mismatch repair_Homo sapiens_hsa034300.91195561
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.90830132
74Influenza A_Homo sapiens_hsa051640.90722554
75Rheumatoid arthritis_Homo sapiens_hsa053230.89416160
76Fatty acid biosynthesis_Homo sapiens_hsa000610.89186822
77Fructose and mannose metabolism_Homo sapiens_hsa000510.88325648
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87370312
79Hematopoietic cell lineage_Homo sapiens_hsa046400.85371885
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84602274
81Asthma_Homo sapiens_hsa053100.83599865
82Glutathione metabolism_Homo sapiens_hsa004800.81802664
83Salmonella infection_Homo sapiens_hsa051320.78937365
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78496692
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76807512
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76706330
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76510671
88Pertussis_Homo sapiens_hsa051330.75427984
89Other glycan degradation_Homo sapiens_hsa005110.74978185
90Alcoholism_Homo sapiens_hsa050340.74211125
91Metabolic pathways_Homo sapiens_hsa011000.74054068
92Vitamin digestion and absorption_Homo sapiens_hsa049770.73905136
93Herpes simplex infection_Homo sapiens_hsa051680.73099549
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71061055
95N-Glycan biosynthesis_Homo sapiens_hsa005100.70660076
96Fanconi anemia pathway_Homo sapiens_hsa034600.69992020
97Chemical carcinogenesis_Homo sapiens_hsa052040.69782451
98Small cell lung cancer_Homo sapiens_hsa052220.68645682
99DNA replication_Homo sapiens_hsa030300.68342934
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68271826
101Phototransduction_Homo sapiens_hsa047440.68171915
102Biosynthesis of amino acids_Homo sapiens_hsa012300.67213755
103Renin-angiotensin system_Homo sapiens_hsa046140.66422021
104Spliceosome_Homo sapiens_hsa030400.66010647
105Platelet activation_Homo sapiens_hsa046110.64890863
106Synaptic vesicle cycle_Homo sapiens_hsa047210.61957653
107Parkinsons disease_Homo sapiens_hsa050120.58874579
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.58587448
109Peroxisome_Homo sapiens_hsa041460.57871936
110beta-Alanine metabolism_Homo sapiens_hsa004100.57796825
111Hepatitis C_Homo sapiens_hsa051600.57778943
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56759391
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56468158
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55073860
115Tuberculosis_Homo sapiens_hsa051520.54974809
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53558223
117Hepatitis B_Homo sapiens_hsa051610.52689712
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51712684
119Arginine and proline metabolism_Homo sapiens_hsa003300.49477676
120Toxoplasmosis_Homo sapiens_hsa051450.48541998
121Viral carcinogenesis_Homo sapiens_hsa052030.47961219
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47253804
123Alzheimers disease_Homo sapiens_hsa050100.47212822
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47126300
125Circadian rhythm_Homo sapiens_hsa047100.46656207
126Legionellosis_Homo sapiens_hsa051340.45852486
127TGF-beta signaling pathway_Homo sapiens_hsa043500.45481774
128Tight junction_Homo sapiens_hsa045300.42007281
129Fatty acid degradation_Homo sapiens_hsa000710.41348516
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40876139
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40486267
132Epstein-Barr virus infection_Homo sapiens_hsa051690.39375880
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37492798
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35797836
135Focal adhesion_Homo sapiens_hsa045100.35693483
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.35012834
137Complement and coagulation cascades_Homo sapiens_hsa046100.34120681
138Oocyte meiosis_Homo sapiens_hsa041140.33862586
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31767638
140Prostate cancer_Homo sapiens_hsa052150.29518110
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24935323
142Malaria_Homo sapiens_hsa051440.24219238
143Butanoate metabolism_Homo sapiens_hsa006500.22531087

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