BLZF2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of interleukin-8 biosynthetic process (GO:0045416)6.56229211
2positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610815.78871970
3regulation of interleukin-8 biosynthetic process (GO:0045414)4.87915384
4neutrophil mediated immunity (GO:0002446)4.87544956
5activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.68671437
6endothelial cell morphogenesis (GO:0001886)4.57984324
7muscle cell fate commitment (GO:0042693)4.56221829
8response to redox state (GO:0051775)4.33551941
9proteasome assembly (GO:0043248)4.31810782
10regulation of cytokine secretion involved in immune response (GO:0002739)3.99639834
11myeloid leukocyte mediated immunity (GO:0002444)3.98803251
12cell migration involved in heart development (GO:0060973)3.98309492
13fibroblast migration (GO:0010761)3.94315477
14negative regulation of chemokine production (GO:0032682)3.80255358
15muscle organ morphogenesis (GO:0048644)3.78165960
16dopamine transport (GO:0015872)3.75445391
17membrane raft organization (GO:0031579)3.72440965
18disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.54956198
19killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.54956198
20detection of molecule of bacterial origin (GO:0032490)3.50254439
21DNA deamination (GO:0045006)3.43605856
22cellular extravasation (GO:0045123)3.42982793
23RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.39902546
24interleukin-6-mediated signaling pathway (GO:0070102)3.39321911
25positive regulation of macrophage cytokine production (GO:0060907)3.38417112
26platelet dense granule organization (GO:0060155)3.37061926
27negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.30105255
28regulation of interleukin-8 secretion (GO:2000482)3.26808657
29protein K11-linked deubiquitination (GO:0035871)3.20730120
30negative regulation of interleukin-8 production (GO:0032717)3.13290746
31mesenchymal-epithelial cell signaling (GO:0060638)3.09676091
32regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.03498753
33regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.01213206
34female genitalia development (GO:0030540)3.00814494
35negative regulation of cell aging (GO:0090344)3.00809821
36secretory granule organization (GO:0033363)2.99418470
37negative regulation of mast cell activation (GO:0033004)2.96744774
38negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.95603279
39protein heterotetramerization (GO:0051290)2.94013512
40establishment of protein localization to Golgi (GO:0072600)2.93024790
41anterior/posterior axis specification, embryo (GO:0008595)2.92360896
42purine deoxyribonucleotide catabolic process (GO:0009155)2.90050334
43regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.86398978
44glomerular visceral epithelial cell development (GO:0072015)2.86375949
45pericardium development (GO:0060039)2.86265066
46embryonic forelimb morphogenesis (GO:0035115)2.86212101
47aldehyde catabolic process (GO:0046185)2.85587888
48uterus development (GO:0060065)2.84228512
49protein targeting to Golgi (GO:0000042)2.83651195
50response to fungus (GO:0009620)2.83419445
51endocardial cushion development (GO:0003197)2.83188281
52activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.81851216
53ventricular septum development (GO:0003281)2.81304618
54positive regulation of protein autophosphorylation (GO:0031954)2.80091375
55peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.78630450
56protein K6-linked ubiquitination (GO:0085020)2.77897996
57anterograde synaptic vesicle transport (GO:0048490)2.75280777
58negative regulation of axon extension involved in axon guidance (GO:0048843)2.73949613
59deoxyribose phosphate catabolic process (GO:0046386)2.73398964
60negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.72888157
61nodal signaling pathway (GO:0038092)2.71790989
62blastocyst development (GO:0001824)2.71145064
63mitotic cell cycle arrest (GO:0071850)2.69212593
64regulation of macrophage cytokine production (GO:0010935)2.69005291
65indole-containing compound catabolic process (GO:0042436)2.65275817
66indolalkylamine catabolic process (GO:0046218)2.65275817
67tryptophan catabolic process (GO:0006569)2.65275817
68positive regulation of interleukin-8 secretion (GO:2000484)2.64411053
69regulation of chemokine biosynthetic process (GO:0045073)2.62705453
70branching involved in prostate gland morphogenesis (GO:0060442)2.62019760
71leukotriene biosynthetic process (GO:0019370)2.61836973
72regulation of establishment of cell polarity (GO:2000114)2.61283199
73muscle cell cellular homeostasis (GO:0046716)2.60594464
74tryptophan metabolic process (GO:0006568)2.60411773
75regulation of interleukin-1 beta secretion (GO:0050706)2.58585250
76negative regulation of growth of symbiont in host (GO:0044130)2.57884489
77negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.57884489
78modulation of growth of symbiont involved in interaction with host (GO:0044144)2.57884489
79regulation of growth of symbiont in host (GO:0044126)2.57884489
80negative regulation of cytokine secretion (GO:0050710)2.56197228
81glyoxylate metabolic process (GO:0046487)2.55935715
82regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.55034712
83positive regulation of toll-like receptor signaling pathway (GO:0034123)2.54820397
84killing of cells of other organism (GO:0031640)2.54507215
85disruption of cells of other organism (GO:0044364)2.54507215
86regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.54030658
87embryonic cranial skeleton morphogenesis (GO:0048701)2.52582158
88endocrine hormone secretion (GO:0060986)2.50963978
89kynurenine metabolic process (GO:0070189)2.49564383
90regulation of interferon-beta biosynthetic process (GO:0045357)2.48210095
91signal peptide processing (GO:0006465)2.48026715
92response to hyperoxia (GO:0055093)2.47934575
93response to increased oxygen levels (GO:0036296)2.47934575
94positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.45914100
95replicative senescence (GO:0090399)2.44816654
96hepatocyte apoptotic process (GO:0097284)2.44314807
97UDP-N-acetylglucosamine metabolic process (GO:0006047)2.43460032
98positive regulation of interleukin-8 production (GO:0032757)2.43057639
99neutrophil activation involved in immune response (GO:0002283)2.42274734
100retrograde transport, vesicle recycling within Golgi (GO:0000301)2.40235858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human4.60906445
2CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.24156902
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.09598635
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.03751574
5VDR_22108803_ChIP-Seq_LS180_Human3.00234819
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.97052947
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.91957628
8ELK1_19687146_ChIP-ChIP_HELA_Human2.57733812
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55944881
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51891858
11CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.41555934
12BRD4_25478319_ChIP-Seq_HGPS_Human2.35123724
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.31956724
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.21700712
15GBX2_23144817_ChIP-Seq_PC3_Human2.20030983
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.11621640
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11534892
18CJUN_26792858_Chip-Seq_BT549_Human2.02906630
19ZNF274_21170338_ChIP-Seq_K562_Hela2.01189935
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94009217
21P300_19829295_ChIP-Seq_ESCs_Human1.88753454
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.86594034
23TP53_16413492_ChIP-PET_HCT116_Human1.80018255
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79154738
25TAF15_26573619_Chip-Seq_HEK293_Human1.72497672
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.71418368
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.67971865
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.66623576
29FOXM1_26456572_ChIP-Seq_MCF-7_Human1.61105511
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60972531
31EWS_26573619_Chip-Seq_HEK293_Human1.57905865
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.57442981
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55631748
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54013255
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.52391278
36FUS_26573619_Chip-Seq_HEK293_Human1.50178342
37JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49039343
38ER_23166858_ChIP-Seq_MCF-7_Human1.46814570
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45773962
40CRX_20693478_ChIP-Seq_RETINA_Mouse1.44195047
41BCAT_22108803_ChIP-Seq_LS180_Human1.43798259
42CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.42657261
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.42515360
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42243010
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40057807
46CBP_20019798_ChIP-Seq_JUKART_Human1.39094632
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39094632
48TCF4_22108803_ChIP-Seq_LS180_Human1.37693523
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.36172928
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33881437
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31897854
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.31860373
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31356116
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26752266
55CDX2_22108803_ChIP-Seq_LS180_Human1.26645312
56SMAD4_21799915_ChIP-Seq_A2780_Human1.26175193
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25302178
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25302178
59SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.24008579
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22579509
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.22466386
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21696202
63OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20552052
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18584369
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.17662969
66TP53_18474530_ChIP-ChIP_U2OS_Human1.17602494
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16276349
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.16037345
69SOX2_19829295_ChIP-Seq_ESCs_Human1.15873649
70NANOG_19829295_ChIP-Seq_ESCs_Human1.15873649
71VDR_24787735_ChIP-Seq_THP-1_Human1.15365472
72RXR_22108803_ChIP-Seq_LS180_Human1.15002850
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14865837
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14309835
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13843492
76JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13807647
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.13456372
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12049250
79VDR_23849224_ChIP-Seq_CD4+_Human1.11968094
80SALL4_22934838_ChIP-ChIP_CD34+_Human1.11376972
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09936005
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.08435677
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07900968
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07759301
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07509319
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07419763
87STAT3_23295773_ChIP-Seq_U87_Human1.07208776
88GATA3_26560356_Chip-Seq_TH2_Human1.06358906
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05299604
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.05205597
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.04868046
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03852497
93SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02834777
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.02504524
95P53_22387025_ChIP-Seq_ESCs_Mouse1.02104162
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02058798
97POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00640317
98RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00084102
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98647876
100ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98092315

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane5.30397358
2MP0006054_spinal_hemorrhage4.88443973
3MP0005503_abnormal_tendon_morphology4.12990513
4MP0003195_calcinosis3.79912346
5MP0000569_abnormal_digit_pigmentation3.02628669
6MP0009780_abnormal_chondrocyte_physiolo2.88174736
7MP0000427_abnormal_hair_cycle2.86925766
8MP0003191_abnormal_cellular_cholesterol2.77711072
9MP0005367_renal/urinary_system_phenotyp2.73748878
10MP0000516_abnormal_urinary_system2.73748878
11MP0004883_abnormal_blood_vessel2.40708195
12MP0000537_abnormal_urethra_morphology2.35307585
13MP0008438_abnormal_cutaneous_collagen2.29952022
14MP0002234_abnormal_pharynx_morphology2.23460750
15MP0005164_abnormal_response_to2.21745332
16MP0003315_abnormal_perineum_morphology2.15520872
17MP0008260_abnormal_autophagy1.97895641
18MP0002108_abnormal_muscle_morphology1.81633955
19MP0005187_abnormal_penis_morphology1.79457522
20MP0003567_abnormal_fetal_cardiomyocyte1.77325624
21MP0004272_abnormal_basement_membrane1.68445201
22MP0003724_increased_susceptibility_to1.67908431
23MP0002102_abnormal_ear_morphology1.66520674
24MP0000538_abnormal_urinary_bladder1.64446508
25MP0003279_aneurysm1.62752556
26MP0003252_abnormal_bile_duct1.60844764
27MP0002332_abnormal_exercise_endurance1.55626953
28MP0009053_abnormal_anal_canal1.55401440
29MP0009697_abnormal_copulation1.50025928
30MP0002009_preneoplasia1.49222879
31MP0005174_abnormal_tail_pigmentation1.46370591
32MP0003828_pulmonary_edema1.45455415
33MP0008877_abnormal_DNA_methylation1.44759863
34MP0002160_abnormal_reproductive_system1.40380631
35MP0003011_delayed_dark_adaptation1.35620877
36MP0000639_abnormal_adrenal_gland1.35113661
37MP0002163_abnormal_gland_morphology1.34703779
38MP0000750_abnormal_muscle_regeneration1.29661231
39MP0010386_abnormal_urinary_bladder1.28965214
40MP0002166_altered_tumor_susceptibility1.26050443
41MP0005275_abnormal_skin_tensile1.23357987
42MP0000015_abnormal_ear_pigmentation1.20736141
43MP0004019_abnormal_vitamin_homeostasis1.19902948
44MP0008057_abnormal_DNA_replication1.15616584
45MP0002115_abnormal_skeleton_extremities1.15363680
46MP0001853_heart_inflammation1.11087110
47MP0009250_abnormal_appendicular_skeleto1.10887294
48MP0009764_decreased_sensitivity_to1.10085917
49MP0005023_abnormal_wound_healing1.08553118
50MP0001243_abnormal_dermal_layer1.06849973
51MP0003183_abnormal_peptide_metabolism1.06746366
52MP0002006_tumorigenesis1.05770888
53MP0002876_abnormal_thyroid_physiology1.05653953
54MP0000647_abnormal_sebaceous_gland1.04560865
55MP0005379_endocrine/exocrine_gland_phen1.01617335
56MP0002277_abnormal_respiratory_mucosa1.01305038
57MP0002282_abnormal_trachea_morphology1.00532117
58MP0000767_abnormal_smooth_muscle1.00421434
59MP0001756_abnormal_urination0.97447168
60MP0005551_abnormal_eye_electrophysiolog0.96887747
61MP0005508_abnormal_skeleton_morphology0.93282145
62MP0005376_homeostasis/metabolism_phenot0.90916097
63MP0003186_abnormal_redox_activity0.90516967
64MP0001958_emphysema0.90030984
65MP0005253_abnormal_eye_physiology0.89332654
66MP0005390_skeleton_phenotype0.87158311
67MP0001835_abnormal_antigen_presentation0.84474044
68MP0004084_abnormal_cardiac_muscle0.84155666
69MP0001119_abnormal_female_reproductive0.83128237
70MP0009384_cardiac_valve_regurgitation0.81605142
71MP0000733_abnormal_muscle_development0.81600310
72MP0005595_abnormal_vascular_smooth0.81205166
73MP0002109_abnormal_limb_morphology0.78802409
74MP0001542_abnormal_bone_strength0.75480368
75MP0002168_other_aberrant_phenotype0.75075041
76MP0000383_abnormal_hair_follicle0.74193807
77MP0005193_abnormal_anterior_eye0.72762156
78MP0005257_abnormal_intraocular_pressure0.71423032
79MP0006082_CNS_inflammation0.71317049
80MP0004484_altered_response_of0.71080135
81MP0008872_abnormal_physiological_respon0.70009603
82MP0002419_abnormal_innate_immunity0.69728620
83MP0002095_abnormal_skin_pigmentation0.69343536
84MP0003937_abnormal_limbs/digits/tail_de0.67740120
85MP0002113_abnormal_skeleton_development0.67712171
86MP0009785_altered_susceptibility_to0.67640761
87MP0001915_intracranial_hemorrhage0.67281741
88MP0002932_abnormal_joint_morphology0.66364950
89MP0001299_abnormal_eye_distance/0.66128794
90MP0009115_abnormal_fat_cell0.64120147
91MP0000749_muscle_degeneration0.63957095
92MP0005084_abnormal_gallbladder_morpholo0.63878948
93MP0003448_altered_tumor_morphology0.63469860
94MP0005397_hematopoietic_system_phenotyp0.61924905
95MP0001545_abnormal_hematopoietic_system0.61924905
96MP0003091_abnormal_cell_migration0.61790042
97MP0000372_irregular_coat_pigmentation0.60386913
98MP0003755_abnormal_palate_morphology0.60148549
99MP0005369_muscle_phenotype0.59209460
100MP0000230_abnormal_systemic_arterial0.56439238

Predicted human phenotypes

RankGene SetZ-score
1Aplasia of the musculature (HP:0100854)5.58803600
2Hyperventilation (HP:0002883)4.43758504
3Spontaneous abortion (HP:0005268)4.35068472
4Short middle phalanx of the 5th finger (HP:0004220)4.30534229
5Spondylolisthesis (HP:0003302)3.99055414
6Popliteal pterygium (HP:0009756)3.87475042
7Abnormality of the 2nd finger (HP:0004100)3.82374453
8Metaphyseal dysplasia (HP:0100255)3.79506423
9Aplasia/Hypoplasia involving the musculature (HP:0001460)3.78065146
10Increased number of teeth (HP:0011069)3.52038258
11Hypoplastic scapulae (HP:0000882)3.51469847
12Aplasia/Hypoplasia of the scapulae (HP:0006713)3.51469847
13Abnormality of placental membranes (HP:0011409)3.48285066
14Amniotic constriction ring (HP:0009775)3.48285066
15Short 5th finger (HP:0009237)3.45179112
16Spinal cord lesions (HP:0100561)3.41399896
17Syringomyelia (HP:0003396)3.41399896
18Abnormality of the phalanges of the 2nd finger (HP:0009541)3.18561647
19Aortic aneurysm (HP:0004942)3.11775798
20Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.10666169
21Abnormal foot bone ossification (HP:0010675)3.08954767
22Hypoplastic labia majora (HP:0000059)2.97402312
23Abnormal tarsal ossification (HP:0008369)2.93591313
24Severe visual impairment (HP:0001141)2.91495012
25Short 1st metacarpal (HP:0010034)2.80157524
26Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.80157524
27Type 2 muscle fiber atrophy (HP:0003554)2.78889684
28Abnormality of the labia majora (HP:0012881)2.74908494
29Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.72200744
30Follicular hyperkeratosis (HP:0007502)2.71864715
31Methylmalonic aciduria (HP:0012120)2.65818619
32Patchy hypopigmentation of hair (HP:0011365)2.58293564
33Absent frontal sinuses (HP:0002688)2.55639908
34Narrow palate (HP:0000189)2.54125468
35Febrile seizures (HP:0002373)2.51960754
36Hypoplastic ischia (HP:0003175)2.51576996
37White forelock (HP:0002211)2.51364138
38Mesomelia (HP:0003027)2.50204013
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.46656433
40Pancreatic cysts (HP:0001737)2.46525676
41Abnormality of the 1st metacarpal (HP:0010009)2.40794701
42Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.40764409
43Ureteral stenosis (HP:0000071)2.40358291
44Hypoalphalipoproteinemia (HP:0003233)2.32152414
45Ureteral obstruction (HP:0006000)2.28538067
46Small hand (HP:0200055)2.28060811
47Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.25236154
48Aplastic anemia (HP:0001915)2.24601773
49Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.21515590
50Hypothermia (HP:0002045)2.18727200
51Short middle phalanx of finger (HP:0005819)2.17218029
52Glucose intolerance (HP:0000833)2.16631721
53Aortic dissection (HP:0002647)2.16471711
54Bifid tongue (HP:0010297)2.14685037
55Decreased central vision (HP:0007663)2.14596532
56Abnormality of the ischium (HP:0003174)2.12382550
57Abnormality of incisor morphology (HP:0011063)2.11499119
58Albinism (HP:0001022)2.09523350
59Hypoplastic iliac wings (HP:0002866)2.08739436
60Wide intermamillary distance (HP:0006610)2.06685467
61Acute necrotizing encephalopathy (HP:0006965)2.04667240
62Attenuation of retinal blood vessels (HP:0007843)2.03246426
63Abnormality of the phalanges of the 5th finger (HP:0004213)2.01645337
64Disproportionate short-trunk short stature (HP:0003521)2.01484281
65Muscle fiber atrophy (HP:0100295)1.98375595
66Abnormality of secondary sexual hair (HP:0009888)1.95988203
67Abnormality of the axillary hair (HP:0100134)1.95988203
68Sensory axonal neuropathy (HP:0003390)1.94866078
69Dyschromatopsia (HP:0007641)1.93607456
70Breast hypoplasia (HP:0003187)1.88303464
71Pancreatic fibrosis (HP:0100732)1.88173242
72Gaze-evoked nystagmus (HP:0000640)1.85598829
73Acute encephalopathy (HP:0006846)1.85178797
74Atonic seizures (HP:0010819)1.85086138
75Abnormal hand bone ossification (HP:0010660)1.84439667
76Vascular tortuosity (HP:0004948)1.84426290
77Eosinophilia (HP:0001880)1.84335588
78Cystic hygroma (HP:0000476)1.82393701
79Abnormality of the parietal bone (HP:0002696)1.82083650
80Poor head control (HP:0002421)1.81116158
81Microretrognathia (HP:0000308)1.79357892
82Progressive macrocephaly (HP:0004481)1.78028370
83Short hallux (HP:0010109)1.77930077
84Septate vagina (HP:0001153)1.77573402
85Flared iliac wings (HP:0002869)1.76298633
86Nemaline bodies (HP:0003798)1.76022346
87Abnormality of carpal bone ossification (HP:0006257)1.76001702
88Coronal craniosynostosis (HP:0004440)1.74566864
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.73561716
90Abnormal rod and cone electroretinograms (HP:0008323)1.73480935
91Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.71593456
92Cardiovascular calcification (HP:0011915)1.68276992
93Hydroxyprolinuria (HP:0003080)1.67422904
94Abnormality of proline metabolism (HP:0010907)1.67422904
95Abnormality of midbrain morphology (HP:0002418)1.67115978
96Molar tooth sign on MRI (HP:0002419)1.67115978
97Abnormality of the frontal sinuses (HP:0002687)1.65992892
98Congenital stationary night blindness (HP:0007642)1.64649643
99Shawl scrotum (HP:0000049)1.64618789
100Aplasia/Hypoplasia of the hallux (HP:0008362)1.64542194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT36.17330800
2FRK3.71678091
3ACVR1B3.29897757
4STK162.96501309
5NUAK12.78329527
6MYLK2.66899197
7MAP3K122.50258876
8BMPR1B2.33829724
9BRSK22.23279602
10CDK82.21578288
11PIK3CG2.16895064
12MKNK22.02506317
13PTK2B1.98934544
14YES11.81862213
15MST41.77018407
16BUB11.66214245
17ERBB31.66040426
18TRPM71.65603931
19PDK21.56604759
20PAK31.55064790
21PBK1.46616021
22TRIM281.45823566
23EIF2AK31.44838846
24ILK1.40083171
25CAMKK21.38773814
26PLK21.37441604
27BMPR21.33937685
28MUSK1.30144724
29STK38L1.28625406
30GRK11.23841749
31TGFBR21.16944616
32RIPK41.13302483
33ADRBK11.08452541
34MELK1.05571462
35STK381.02124022
36PRKCE0.97919366
37MKNK10.93153899
38FER0.93023214
39MAP3K20.91525004
40ROCK10.89374968
41IRAK10.88010158
42VRK20.87277046
43PLK30.86946133
44TAOK30.85969882
45SIK30.85065023
46ABL20.83103516
47PTK20.80554763
48STK30.78715591
49MET0.77117294
50FGR0.75475049
51LIMK10.75452279
52FLT30.71462569
53TGFBR10.69043565
54IKBKB0.67185166
55DYRK30.63047459
56WNK30.62314716
57HIPK20.61034072
58ERBB40.60166622
59MAP3K140.59896376
60CSF1R0.59893059
61ABL10.59732941
62GRK50.57383089
63PRKD20.56022858
64EIF2AK10.55885069
65TXK0.55331400
66RAF10.54611991
67FGFR10.53978062
68TEC0.53476663
69CAMK40.52979112
70PRKG10.50640813
71NLK0.50431208
72NEK10.49999611
73BRSK10.47905796
74WNK40.47195959
75PRKD30.47048107
76IKBKE0.46723086
77ROCK20.46377734
78WEE10.43010133
79MAP2K30.42998929
80PDGFRB0.42094260
81TYK20.41770059
82BCR0.41582498
83PRKD10.40624348
84IGF1R0.40465716
85PAK20.38912802
86LATS10.38121253
87DYRK1B0.37302151
88GRK70.36322046
89HCK0.35629658
90MAP3K40.35245566
91MAP2K10.34048965
92EPHA20.32758614
93DDR20.32144687
94CAMK2D0.31742350
95VRK10.29824741
96EIF2AK20.29787316
97EGFR0.26938925
98KDR0.26582086
99CAMK10.25671041
100PDK10.25535726

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.17881270
2Protein export_Homo sapiens_hsa030603.97309715
3African trypanosomiasis_Homo sapiens_hsa051432.56621191
4Legionellosis_Homo sapiens_hsa051342.04931504
5Selenocompound metabolism_Homo sapiens_hsa004502.02590805
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01447078
7Oxidative phosphorylation_Homo sapiens_hsa001902.00003595
8Parkinsons disease_Homo sapiens_hsa050121.98541906
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88434128
10RNA polymerase_Homo sapiens_hsa030201.83990658
11Basal transcription factors_Homo sapiens_hsa030221.83312632
12SNARE interactions in vesicular transport_Homo sapiens_hsa041301.75561853
13Huntingtons disease_Homo sapiens_hsa050161.75552223
14Nitrogen metabolism_Homo sapiens_hsa009101.74342962
15One carbon pool by folate_Homo sapiens_hsa006701.66948118
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.59715687
17RNA degradation_Homo sapiens_hsa030181.54281640
18Alzheimers disease_Homo sapiens_hsa050101.52924501
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51157728
20Asthma_Homo sapiens_hsa053101.50274925
21Regulation of autophagy_Homo sapiens_hsa041401.50107406
22Malaria_Homo sapiens_hsa051441.49717449
23Homologous recombination_Homo sapiens_hsa034401.44319795
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39515773
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28601548
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27687471
27TGF-beta signaling pathway_Homo sapiens_hsa043501.26270951
28p53 signaling pathway_Homo sapiens_hsa041151.25609542
29Propanoate metabolism_Homo sapiens_hsa006401.25075194
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21073567
31Complement and coagulation cascades_Homo sapiens_hsa046101.20700733
32Small cell lung cancer_Homo sapiens_hsa052221.20623093
33Mineral absorption_Homo sapiens_hsa049781.11833258
34Mismatch repair_Homo sapiens_hsa034301.11686764
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10128849
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09840420
37Glutathione metabolism_Homo sapiens_hsa004801.07536658
38Sulfur metabolism_Homo sapiens_hsa009201.05926250
39RNA transport_Homo sapiens_hsa030131.04373407
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.03390197
41Tuberculosis_Homo sapiens_hsa051521.02626968
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00283597
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99989794
44Phototransduction_Homo sapiens_hsa047440.98455891
45Fanconi anemia pathway_Homo sapiens_hsa034600.93501798
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92420338
47Melanoma_Homo sapiens_hsa052180.92384749
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89209567
49Cell cycle_Homo sapiens_hsa041100.88760117
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87064104
51Olfactory transduction_Homo sapiens_hsa047400.86156591
52Dorso-ventral axis formation_Homo sapiens_hsa043200.85612312
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84319361
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83983155
55Hepatitis B_Homo sapiens_hsa051610.83833522
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83648122
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.82107154
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80218700
59PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79243891
60HIF-1 signaling pathway_Homo sapiens_hsa040660.74435192
61Arachidonic acid metabolism_Homo sapiens_hsa005900.74357991
62Rheumatoid arthritis_Homo sapiens_hsa053230.71809689
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69963777
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69085949
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68105134
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64807984
67Calcium signaling pathway_Homo sapiens_hsa040200.64112173
68Proteoglycans in cancer_Homo sapiens_hsa052050.64051091
69Osteoclast differentiation_Homo sapiens_hsa043800.63995030
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62839962
71FoxO signaling pathway_Homo sapiens_hsa040680.62226825
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.61909865
73Nucleotide excision repair_Homo sapiens_hsa034200.61640509
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60213095
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.59416723
76Hematopoietic cell lineage_Homo sapiens_hsa046400.59236330
77Prostate cancer_Homo sapiens_hsa052150.58595873
78Amoebiasis_Homo sapiens_hsa051460.56724531
79Pyrimidine metabolism_Homo sapiens_hsa002400.56360921
80Focal adhesion_Homo sapiens_hsa045100.55164146
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53617841
82Purine metabolism_Homo sapiens_hsa002300.53169800
83TNF signaling pathway_Homo sapiens_hsa046680.52364185
84Measles_Homo sapiens_hsa051620.51718015
85Adherens junction_Homo sapiens_hsa045200.51298812
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.50724870
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49501478
88Thyroid hormone synthesis_Homo sapiens_hsa049180.47311099
89Platelet activation_Homo sapiens_hsa046110.46298916
90Renin secretion_Homo sapiens_hsa049240.44940453
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.44592425
92Taste transduction_Homo sapiens_hsa047420.44298288
93Graft-versus-host disease_Homo sapiens_hsa053320.44193294
94mRNA surveillance pathway_Homo sapiens_hsa030150.41515117
95Sulfur relay system_Homo sapiens_hsa041220.40310091
96Pertussis_Homo sapiens_hsa051330.39203906
97Influenza A_Homo sapiens_hsa051640.38907364
98Tryptophan metabolism_Homo sapiens_hsa003800.38452194
99Systemic lupus erythematosus_Homo sapiens_hsa053220.36140803
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36065325

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