BMF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.83415060
2positive regulation by organism of defense response of other organism involved in symbiotic interact4.83415060
3modulation by symbiont of host immune response (GO:0052553)4.83415060
4positive regulation by symbiont of host defense response (GO:0052509)4.83415060
5modulation by symbiont of host defense response (GO:0052031)4.83415060
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.83415060
7regulation of B cell receptor signaling pathway (GO:0050855)4.31503277
8response to peptidoglycan (GO:0032494)4.28237016
9positive regulation of gamma-delta T cell activation (GO:0046645)4.25561095
10immunoglobulin mediated immune response (GO:0016064)4.13706104
11detection of other organism (GO:0098543)4.10818350
12regulation of gamma-delta T cell differentiation (GO:0045586)4.08716095
13detection of bacterium (GO:0016045)4.05152286
14negative regulation of erythrocyte differentiation (GO:0045647)4.04981686
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.03124075
16negative regulation of cell killing (GO:0031342)4.03124075
17negative regulation of interleukin-12 production (GO:0032695)3.90540997
18hepatocyte apoptotic process (GO:0097284)3.87970109
19regulation of gamma-delta T cell activation (GO:0046643)3.71889386
20germ cell migration (GO:0008354)3.70211339
21positive regulation of B cell differentiation (GO:0045579)3.64124158
22regulation of dendritic cell antigen processing and presentation (GO:0002604)3.56921694
23germinal center formation (GO:0002467)3.51800682
24defense response to protozoan (GO:0042832)3.48230737
25regulation of antigen processing and presentation (GO:0002577)3.40512926
26B cell homeostasis (GO:0001782)3.37124018
27regulation of mast cell degranulation (GO:0043304)3.36504104
28serine transport (GO:0032329)3.35897436
29antigen processing and presentation of endogenous antigen (GO:0019883)3.33118215
30CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.33022358
31V(D)J recombination (GO:0033151)3.31878441
32positive thymic T cell selection (GO:0045059)3.31023680
33interferon-gamma-mediated signaling pathway (GO:0060333)3.29948307
34detection of external biotic stimulus (GO:0098581)3.29201032
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.28613412
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28613412
37regulation of T-helper 2 cell differentiation (GO:0045628)3.27959662
38regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.26947531
39regulation of leukocyte degranulation (GO:0043300)3.24594441
40natural killer cell differentiation (GO:0001779)3.23845698
41response to host immune response (GO:0052572)3.23506550
42response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.23506550
43growth hormone receptor signaling pathway (GO:0060396)3.23456272
44positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.23395463
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.22898272
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.21641734
47response to protozoan (GO:0001562)3.21168825
48regulation of T-helper 1 cell differentiation (GO:0045625)3.16215159
49response to host (GO:0075136)3.15681775
50response to host defenses (GO:0052200)3.15681775
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.15681775
52cellular extravasation (GO:0045123)3.14816087
53B cell receptor signaling pathway (GO:0050853)3.14512261
54L-serine transport (GO:0015825)3.14233147
55positive regulation of SMAD protein import into nucleus (GO:0060391)3.13705403
56response to type I interferon (GO:0034340)3.11498484
57cellular response to type I interferon (GO:0071357)3.11482465
58type I interferon signaling pathway (GO:0060337)3.11482465
59regulation of myeloid leukocyte mediated immunity (GO:0002886)3.07822670
60B cell mediated immunity (GO:0019724)3.07499035
61cellular hyperosmotic response (GO:0071474)3.07227230
62positive regulation of antigen processing and presentation (GO:0002579)3.07044885
63T-helper 1 type immune response (GO:0042088)3.04324276
64regulation of mast cell activation involved in immune response (GO:0033006)3.02316198
65detection of biotic stimulus (GO:0009595)3.01783844
66positive regulation of mast cell activation (GO:0033005)3.01477880
67positive regulation of type 2 immune response (GO:0002830)3.01292892
68regulation of extracellular matrix disassembly (GO:0010715)2.96687993
69positive regulation of interferon-alpha production (GO:0032727)2.96336622
70negative thymic T cell selection (GO:0045060)2.95182453
71production of molecular mediator involved in inflammatory response (GO:0002532)2.94540885
72T cell selection (GO:0045058)2.93096294
73detection of molecule of bacterial origin (GO:0032490)2.91609224
74positive regulation of histone deacetylation (GO:0031065)2.91436933
75thymic T cell selection (GO:0045061)2.90433170
76regulation of interferon-alpha production (GO:0032647)2.88805923
77myeloid dendritic cell differentiation (GO:0043011)2.87618890
78myeloid cell activation involved in immune response (GO:0002275)2.87374990
79regulation of SMAD protein import into nucleus (GO:0060390)2.84789367
80positive regulation of mast cell degranulation (GO:0043306)2.83560760
81positive regulation of mast cell activation involved in immune response (GO:0033008)2.83560760
82macrophage activation involved in immune response (GO:0002281)2.83122620
83regulation of histone H3-K9 methylation (GO:0051570)2.82215007
84cytoplasmic mRNA processing body assembly (GO:0033962)2.80378000
85response to laminar fluid shear stress (GO:0034616)2.79378216
86myeloid dendritic cell activation (GO:0001773)2.79150834
87lipopolysaccharide-mediated signaling pathway (GO:0031663)2.78906914
88cellular response to growth hormone stimulus (GO:0071378)2.78820612
89NIK/NF-kappaB signaling (GO:0038061)2.78816296
90epithelial cell differentiation involved in prostate gland development (GO:0060742)2.78390655
91N-acetylneuraminate metabolic process (GO:0006054)2.74973801
92endothelial tube morphogenesis (GO:0061154)2.72902085
93morphogenesis of an endothelium (GO:0003159)2.72902085
94regulation of B cell differentiation (GO:0045577)2.72862022
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.71731719
96T cell migration (GO:0072678)2.69841719
97macrophage activation (GO:0042116)2.69134588
98regulation of mast cell activation (GO:0033003)2.68841483
99regulation of hippo signaling (GO:0035330)2.68178468
100neutrophil activation (GO:0042119)2.67175496
101positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.65819599
102histone H3-K36 demethylation (GO:0070544)2.65190946
103positive regulation by host of viral transcription (GO:0043923)2.65103980
104surfactant homeostasis (GO:0043129)2.64804184
105negative regulation of cytokine production involved in immune response (GO:0002719)2.64702211
106negative T cell selection (GO:0043383)2.64108899
107negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.63943761
108negative regulation of T-helper cell differentiation (GO:0045623)2.63943761
109neutrophil activation involved in immune response (GO:0002283)2.63149047
110hippo signaling (GO:0035329)2.63031271
111T cell costimulation (GO:0031295)2.63008645
112negative regulation of granulocyte differentiation (GO:0030853)2.61836332
113positive regulation of Rap GTPase activity (GO:0032854)2.61051566
114positive regulation of B cell proliferation (GO:0030890)2.60713905
115positive regulation of B cell activation (GO:0050871)2.60651963
116regulation of type I interferon-mediated signaling pathway (GO:0060338)2.60399226
117positive regulation of cellular amide metabolic process (GO:0034250)2.59860033
118lymphocyte costimulation (GO:0031294)2.58419746
119granulocyte activation (GO:0036230)2.56685796
120histone H3-K9 demethylation (GO:0033169)2.47412694
121negative regulation of histone methylation (GO:0031061)2.47396925
122lymph vessel development (GO:0001945)2.44808527
123mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.44558738
124establishment of epithelial cell polarity (GO:0090162)2.43299633
125cellular response to osmotic stress (GO:0071470)2.43031212
126histone lysine demethylation (GO:0070076)2.40141245
127regulation of interferon-beta biosynthetic process (GO:0045357)2.39857940
128chromatin assembly (GO:0031497)2.34107713
129regulation of superoxide anion generation (GO:0032928)2.33158830
130myelin maintenance (GO:0043217)2.32093288
131establishment of apical/basal cell polarity (GO:0035089)2.32060216
132negative regulation of B cell proliferation (GO:0030889)2.28823930
133platelet-derived growth factor receptor signaling pathway (GO:0048008)2.27929502
134JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.27825983
135positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.26588344
136regulation of interleukin-12 biosynthetic process (GO:0045075)2.25504083
137receptor catabolic process (GO:0032801)2.25429973
138cortical actin cytoskeleton organization (GO:0030866)2.25374319
139positive regulation of leukocyte degranulation (GO:0043302)2.25099543
140positive regulation of toll-like receptor signaling pathway (GO:0034123)2.24766996
141response to muramyl dipeptide (GO:0032495)2.24581589
142maternal placenta development (GO:0001893)2.22477900
143dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.21448991
144histone demethylation (GO:0016577)2.19082049
145insulin-like growth factor receptor signaling pathway (GO:0048009)2.18187934
146negative regulation of toll-like receptor signaling pathway (GO:0034122)2.17732354
147lung lobe morphogenesis (GO:0060463)2.16558616
148negative regulation of thymocyte apoptotic process (GO:0070244)2.14417466
149vascular endothelial growth factor signaling pathway (GO:0038084)2.13447397
150response to fluid shear stress (GO:0034405)2.12547774
151regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.11521893
152mucosal-associated lymphoid tissue development (GO:0048537)2.10258586
153Peyers patch development (GO:0048541)2.10258586
154renal system development (GO:0072001)2.09267871
155cellular response to zinc ion (GO:0071294)2.07374452
156negative regulation of bone resorption (GO:0045779)2.06962347
157ruffle organization (GO:0031529)2.06687150
158positive regulation of gene expression, epigenetic (GO:0045815)2.05265706
159planar cell polarity pathway involved in neural tube closure (GO:0090179)2.05136992
160cell proliferation involved in metanephros development (GO:0072203)2.05032565
161lens fiber cell development (GO:0070307)2.03873515
162embryonic foregut morphogenesis (GO:0048617)2.02335915
163patterning of blood vessels (GO:0001569)2.02099222
164regulation of sister chromatid cohesion (GO:0007063)2.02066654
165pathway-restricted SMAD protein phosphorylation (GO:0060389)2.00628404
166regulation of RNA export from nucleus (GO:0046831)2.00443660
167apoptotic cell clearance (GO:0043277)2.00177099
168regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.00172207
169corticosteroid receptor signaling pathway (GO:0031958)1.99980301
170entry into host (GO:0044409)1.99935647
171entry into other organism involved in symbiotic interaction (GO:0051828)1.99935647
172movement in host environment (GO:0052126)1.99935647
173entry into host cell (GO:0030260)1.99935647
174movement in environment of other organism involved in symbiotic interaction (GO:0052192)1.99935647
175entry into cell of other organism involved in symbiotic interaction (GO:0051806)1.99935647
176negative regulation of fatty acid transport (GO:2000192)1.99684766
177regulation of toll-like receptor signaling pathway (GO:0034121)1.99207109
178regulation of T cell tolerance induction (GO:0002664)1.98415845
179mannose metabolic process (GO:0006013)1.97478211

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.52474600
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.05783360
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.68157734
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.39262720
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.18627367
6* MYC_22102868_ChIP-Seq_BL_Human3.16881016
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.15601396
8E2F7_22180533_ChIP-Seq_HELA_Human2.86255825
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.83869879
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.66205735
11VDR_21846776_ChIP-Seq_THP-1_Human2.52563821
12CLOCK_20551151_ChIP-Seq_293T_Human2.37292048
13TCF7_22412390_ChIP-Seq_EML_Mouse2.20364390
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.19109902
15* SPI1_23547873_ChIP-Seq_NB4_Human2.09022039
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05512821
17* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.02199098
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00215506
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.93298717
20* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.91415369
21STAT4_19710469_ChIP-ChIP_TH1__Mouse1.90618484
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.89971386
23* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89617783
24* MAF_26560356_Chip-Seq_TH1_Human1.89211974
25KDM2B_26808549_Chip-Seq_DND41_Human1.85581496
26RUNX_20019798_ChIP-Seq_JUKART_Human1.85071211
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.84491049
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.82010243
29* IRF8_27001747_Chip-Seq_BMDM_Mouse1.79144855
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79135859
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75660517
32VDR_24763502_ChIP-Seq_THP-1_Human1.75247947
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.74212415
34* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71408889
35* MAF_26560356_Chip-Seq_TH2_Human1.70111391
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69711326
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69706437
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67609649
39UTX_26944678_Chip-Seq_JUKART_Human1.66191632
40LXR_22292898_ChIP-Seq_THP-1_Human1.66086863
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64527159
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63872724
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62691371
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60733201
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.58322489
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58167419
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.56174870
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54477046
49* MYB_26560356_Chip-Seq_TH2_Human1.52783900
50* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.52362657
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51254769
52* LXR_22158963_ChIP-Seq_LIVER_Mouse1.50410737
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48721741
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44221338
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42505623
56SCL_19346495_ChIP-Seq_HPC-7_Human1.42155741
57* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41412322
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.39133454
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38195550
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.38169265
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38167217
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36902860
63* ESR1_21235772_ChIP-Seq_MCF-7_Human1.36892296
64MYB_26560356_Chip-Seq_TH1_Human1.36274497
65RXR_22158963_ChIP-Seq_LIVER_Mouse1.34735220
66* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33328488
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28617666
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28397256
69PU_27001747_Chip-Seq_BMDM_Mouse1.27713861
70* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27250325
71RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26794613
72* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25872138
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24595858
74* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24184992
75* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23186191
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21317426
77* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21014319
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20364644
79CIITA_25753668_ChIP-Seq_RAJI_Human1.19866648
80* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19644039
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19404301
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.19099057
83SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18875694
84* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18333970
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.18281500
86FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18249689
87* RACK7_27058665_Chip-Seq_MCF-7_Human1.16254996
88MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15787748
89GATA6_25053715_ChIP-Seq_YYC3_Human1.15577820
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15460940
91PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14983981
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14846445
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14625213
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14124671
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14004587
96GATA1_19941826_ChIP-Seq_K562_Human1.12930841
97* ESR2_21235772_ChIP-Seq_MCF-7_Human1.12806304
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11796584
99KDM2B_26808549_Chip-Seq_K562_Human1.11691847
100TRIM28_21343339_ChIP-Seq_HEK293_Human1.11573451
101SPI1_23127762_ChIP-Seq_K562_Human1.10778298
102VDR_24787735_ChIP-Seq_THP-1_Human1.10710153
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10170462
104LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10065167
105PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08962998
106* NCOR1_26117541_ChIP-Seq_K562_Human1.08712540
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08697778
108FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08375620
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07879227
110CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07674972
111TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06020669
112PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05769726
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04818675
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04611265
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03971963
116RUNX1_22412390_ChIP-Seq_EML_Mouse1.03260772
117CHD1_26751641_Chip-Seq_LNCaP_Human1.00384244
118GATA1_22025678_ChIP-Seq_K562_Human0.99979416
119* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99109501
120CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98101422
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.97850645
122PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97674108
123GATA3_27048872_Chip-Seq_THYMUS_Human0.97573625
124E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95905020
125SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95667519
126* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95352907
127UBF1/2_26484160_Chip-Seq_HMECs_Human0.94850619
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.94566218
129FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94255924
130* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93872389
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92450204
132CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91133560
133TFEB_21752829_ChIP-Seq_HELA_Human0.91106492
134TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90835280
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90059810
136CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89767231
137BCOR_27268052_Chip-Seq_Bcells_Human0.86815551
138* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86491803
139PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82629048
140GATA2_19941826_ChIP-Seq_K562_Human0.81841681
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80549379
142GATA2_21666600_ChIP-Seq_HMVEC_Human0.79597041
143LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79584711

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.06561776
2MP0002166_altered_tumor_susceptibility2.61047957
3MP0002138_abnormal_hepatobiliary_system2.59837831
4MP0002254_reproductive_system_inflammat2.55904213
5MP0003172_abnormal_lysosome_physiology2.55354615
6MP0003705_abnormal_hypodermis_morpholog2.44230854
7MP0003724_increased_susceptibility_to2.36803235
8MP0006054_spinal_hemorrhage2.22744633
9MP0009785_altered_susceptibility_to2.20706630
10MP0003300_gastrointestinal_ulcer2.16994822
11MP0005076_abnormal_cell_differentiation2.13476607
12MP0009278_abnormal_bone_marrow2.10901322
13MP0003191_abnormal_cellular_cholesterol2.08270737
14MP0001835_abnormal_antigen_presentation2.05207122
15MP0000685_abnormal_immune_system1.99779257
16MP0003183_abnormal_peptide_metabolism1.96091365
17MP0005451_abnormal_body_composition1.91635640
18MP0010352_gastrointestinal_tract_polyps1.88727722
19MP0003303_peritoneal_inflammation1.87232785
20MP0001879_abnormal_lymphatic_vessel1.85619129
21MP0002006_tumorigenesis1.82043111
22* MP0001800_abnormal_humoral_immune1.73592160
23MP0004510_myositis1.71753271
24MP0001790_abnormal_immune_system1.71272825
25MP0005387_immune_system_phenotype1.71272825
26MP0008260_abnormal_autophagy1.69777574
27MP0001849_ear_inflammation1.65866870
28MP0001533_abnormal_skeleton_physiology1.63108302
29MP0009333_abnormal_splenocyte_physiolog1.59526996
30MP0002009_preneoplasia1.54556772
31* MP0002452_abnormal_antigen_presenting1.53580515
32MP0003566_abnormal_cell_adhesion1.52256222
33MP0003828_pulmonary_edema1.51239896
34MP0003453_abnormal_keratinocyte_physiol1.50041168
35MP0002998_abnormal_bone_remodeling1.49245502
36MP0009840_abnormal_foam_cell1.49012571
37MP0001853_heart_inflammation1.48458494
38MP0004947_skin_inflammation1.47122836
39MP0000537_abnormal_urethra_morphology1.37251604
40MP0004185_abnormal_adipocyte_glucose1.31743155
41MP0008469_abnormal_protein_level1.31167467
42MP0010678_abnormal_skin_adnexa1.29680422
43MP0000767_abnormal_smooth_muscle1.28468337
44MP0001915_intracranial_hemorrhage1.25804131
45MP0008438_abnormal_cutaneous_collagen1.25564160
46MP0009053_abnormal_anal_canal1.24794036
47MP0010155_abnormal_intestine_physiology1.21666481
48MP0005671_abnormal_response_to1.20463182
49* MP0002420_abnormal_adaptive_immunity1.19181874
50* MP0001819_abnormal_immune_cell1.19091843
51MP0000858_altered_metastatic_potential1.18111225
52MP0000733_abnormal_muscle_development1.18038121
53MP0001958_emphysema1.17111403
54MP0003866_abnormal_defecation1.16711987
55* MP0002723_abnormal_immune_serum1.16149952
56MP0003252_abnormal_bile_duct1.16039947
57MP0003436_decreased_susceptibility_to1.15601941
58* MP0002398_abnormal_bone_marrow1.14465055
59MP0003091_abnormal_cell_migration1.12964398
60MP0010368_abnormal_lymphatic_system1.12646518
61* MP0000716_abnormal_immune_system1.12203090
62MP0000703_abnormal_thymus_morphology1.10271466
63MP0001873_stomach_inflammation1.07801052
64* MP0000689_abnormal_spleen_morphology1.07767442
65MP0002405_respiratory_system_inflammati1.07229297
66MP0005000_abnormal_immune_tolerance1.06058794
67MP0004264_abnormal_extraembryonic_tissu1.04836873
68MP0001663_abnormal_digestive_system1.03944292
69MP0009764_decreased_sensitivity_to1.03245658
70MP0000490_abnormal_crypts_of1.02359742
71MP0002092_abnormal_eye_morphology1.02263982
72MP0002396_abnormal_hematopoietic_system1.02257852
73MP0004808_abnormal_hematopoietic_stem1.01430934
74MP0005310_abnormal_salivary_gland1.01393494
75* MP0002722_abnormal_immune_system1.00460716
76MP0004381_abnormal_hair_follicle0.98328408
77MP0002925_abnormal_cardiovascular_devel0.95180487
78MP0005058_abnormal_lysosome_morphology0.94746987
79MP0003075_altered_response_to0.94613572
80MP0005023_abnormal_wound_healing0.94417512
81* MP0002429_abnormal_blood_cell0.93226623
82MP0003115_abnormal_respiratory_system0.93082840
83MP0004197_abnormal_fetal_growth/weight/0.92883846
84MP0006082_CNS_inflammation0.92568617
85MP0000604_amyloidosis0.90672571
86MP0005397_hematopoietic_system_phenotyp0.90511490
87MP0001545_abnormal_hematopoietic_system0.90511490
88MP0002419_abnormal_innate_immunity0.90251215
89MP0002928_abnormal_bile_duct0.90245091
90MP0001851_eye_inflammation0.89192690
91MP0003279_aneurysm0.88242824
92MP0000609_abnormal_liver_physiology0.86450390
93MP0004272_abnormal_basement_membrane0.85764100
94MP0001346_abnormal_lacrimal_gland0.85154664
95MP0000462_abnormal_digestive_system0.84791006
96MP0005025_abnormal_response_to0.83866233
97MP0002136_abnormal_kidney_physiology0.82585609
98MP0002086_abnormal_extraembryonic_tissu0.82450038
99MP0008004_abnormal_stomach_pH0.82077733
100MP0005666_abnormal_adipose_tissue0.81990887
101MP0003448_altered_tumor_morphology0.81836398
102MP0010030_abnormal_orbit_morphology0.81346170
103MP0000383_abnormal_hair_follicle0.81277102
104MP0002060_abnormal_skin_morphology0.81183164
105MP0002933_joint_inflammation0.80921865
106MP0001845_abnormal_inflammatory_respons0.80763778
107MP0010307_abnormal_tumor_latency0.80161506
108MP0003567_abnormal_fetal_cardiomyocyte0.79212501
109MP0003763_abnormal_thymus_physiology0.78843702
110MP0005166_decreased_susceptibility_to0.76705166
111MP0002088_abnormal_embryonic_growth/wei0.76007343
112MP0005167_abnormal_blood-brain_barrier0.75899422
113MP0004782_abnormal_surfactant_physiolog0.75576159
114MP0000249_abnormal_blood_vessel0.75347639
115MP0003984_embryonic_growth_retardation0.75145753
116MP0002132_abnormal_respiratory_system0.74639804
117MP0001614_abnormal_blood_vessel0.74183557
118MP0005075_abnormal_melanosome_morpholog0.73877430
119MP0002098_abnormal_vibrissa_morphology0.73703717
120MP0000350_abnormal_cell_proliferation0.73281204
121MP0002148_abnormal_hypersensitivity_rea0.72941228
122MP0000627_abnormal_mammary_gland0.72805881
123MP0002139_abnormal_hepatobiliary_system0.71900439
124MP0000465_gastrointestinal_hemorrhage0.71811607
125MP0005464_abnormal_platelet_physiology0.71128985
126MP0001175_abnormal_lung_morphology0.70823354
127MP0005390_skeleton_phenotype0.70746723
128MP0009115_abnormal_fat_cell0.70379172
129MP0005381_digestive/alimentary_phenotyp0.69132387
130MP0003656_abnormal_erythrocyte_physiolo0.68670705
131MP0000343_altered_response_to0.67328135
132MP0005409_darkened_coat_color0.65629576
133MP0001348_abnormal_lacrimal_gland0.62849037
134MP0003795_abnormal_bone_structure0.61843619
135MP0008057_abnormal_DNA_replication0.61811062
136MP0000371_diluted_coat_color0.61432871
137MP0004883_abnormal_blood_vessel0.60389585
138MP0009763_increased_sensitivity_to0.58409693
139MP0003690_abnormal_glial_cell0.58319336
140MP0000015_abnormal_ear_pigmentation0.57805437

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)4.32336953
2Recurrent abscess formation (HP:0002722)4.28867745
3Hematochezia (HP:0002573)3.93191876
4Mediastinal lymphadenopathy (HP:0100721)3.78366192
5Abnormality of liposaccharide metabolism (HP:0010968)3.78227539
6Abnormality of glycosphingolipid metabolism (HP:0004343)3.78227539
7Abnormality of glycolipid metabolism (HP:0010969)3.78227539
8Abnormality of B cell number (HP:0010975)3.48534997
9B lymphocytopenia (HP:0010976)3.48534997
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.46659974
11Thyroiditis (HP:0100646)3.45875518
12Papilloma (HP:0012740)3.38962335
13Verrucae (HP:0200043)3.38962335
14Increased cerebral lipofuscin (HP:0011813)3.35543887
15Recurrent viral infections (HP:0004429)3.33267959
16Vasculitis (HP:0002633)3.32649963
17Recurrent cutaneous fungal infections (HP:0011370)3.30853393
18Chronic mucocutaneous candidiasis (HP:0002728)3.30853393
19Colitis (HP:0002583)3.30216594
20Cellulitis (HP:0100658)3.29179239
21Recurrent gram-negative bacterial infections (HP:0005420)3.28325321
22Agammaglobulinemia (HP:0004432)3.23120426
23Recurrent skin infections (HP:0001581)3.22538051
24Ulnar bowing (HP:0003031)3.19258647
25Myositis (HP:0100614)3.16819037
26Orchitis (HP:0100796)3.14858536
27Cerebral aneurysm (HP:0004944)3.14487155
28Dysostosis multiplex (HP:0000943)3.11223893
29Retrobulbar optic neuritis (HP:0100654)2.97918577
30Optic neuritis (HP:0100653)2.97918577
31Recurrent sinusitis (HP:0011108)2.93926771
32Increased IgE level (HP:0003212)2.88325378
33Obstructive lung disease (HP:0006536)2.86987678
34Chronic obstructive pulmonary disease (HP:0006510)2.86987678
35Restrictive lung disease (HP:0002091)2.83761922
36Abnormality of the fingertips (HP:0001211)2.82528239
37Vacuolated lymphocytes (HP:0001922)2.82424520
38Panhypogammaglobulinemia (HP:0003139)2.81657232
39Eosinophilia (HP:0001880)2.81297079
40Interstitial pulmonary disease (HP:0006530)2.79592901
41T lymphocytopenia (HP:0005403)2.72882662
42Inflammation of the large intestine (HP:0002037)2.72534144
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.72087073
44Pulmonary infiltrates (HP:0002113)2.71399934
45Aortic aneurysm (HP:0004942)2.71283677
46Lymphopenia (HP:0001888)2.68104522
47Abnormality of T cell number (HP:0011839)2.66977071
48Esophageal varix (HP:0002040)2.66912940
49Gastrointestinal inflammation (HP:0004386)2.66840659
50Thoracic kyphosis (HP:0002942)2.62625648
51Vertebral arch anomaly (HP:0008438)2.60273256
52Loss of speech (HP:0002371)2.59776123
53Encephalitis (HP:0002383)2.58733919
54Spontaneous hematomas (HP:0007420)2.55584061
55Hypoplasia of the thymus (HP:0000778)2.51612871
56Mitral valve prolapse (HP:0001634)2.49790587
57Mitral stenosis (HP:0001718)2.47292694
58Gingivitis (HP:0000230)2.45904483
59Gastrointestinal infarctions (HP:0005244)2.45318614
60Stomatitis (HP:0010280)2.44966180
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.44524330
62Small epiphyses (HP:0010585)2.44130903
63Recurrent pneumonia (HP:0006532)2.44030042
64Recurrent fungal infections (HP:0002841)2.43531357
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.43087603
66Short 4th metacarpal (HP:0010044)2.43087603
67Severe combined immunodeficiency (HP:0004430)2.39371395
68IgM deficiency (HP:0002850)2.34433090
69Arterial tortuosity (HP:0005116)2.33056610
70Subacute progressive viral hepatitis (HP:0006572)2.32389384
71Urticaria (HP:0001025)2.31204146
72Chest pain (HP:0100749)2.30041964
73Hemoptysis (HP:0002105)2.29525094
74Combined immunodeficiency (HP:0005387)2.29267811
75Elevated erythrocyte sedimentation rate (HP:0003565)2.27917919
76Recurrent lower respiratory tract infections (HP:0002783)2.27543589
77Chronic diarrhea (HP:0002028)2.27058286
78Abnormality of mucopolysaccharide metabolism (HP:0011020)2.25905221
79Abnormality of polysaccharide metabolism (HP:0011012)2.25905221
80Abnormality of glycosaminoglycan metabolism (HP:0004371)2.25905221
81Mucopolysacchariduria (HP:0008155)2.25706915
82Urinary glycosaminoglycan excretion (HP:0003541)2.25706915
83Rectal prolapse (HP:0002035)2.25247003
84Osteomyelitis (HP:0002754)2.22190115
85Malnutrition (HP:0004395)2.19423527
86Disproportionate tall stature (HP:0001519)2.18778045
87Hyperacusis (HP:0010780)2.18730550
88Myocardial infarction (HP:0001658)2.17707755
89Abnormality of the intervertebral disk (HP:0005108)2.16448057
90Asymmetry of the thorax (HP:0001555)2.14965570
91Abnormality of the thoracic spine (HP:0100711)2.13261917
92Disinhibition (HP:0000734)2.10881901
93Bicuspid aortic valve (HP:0001647)2.09768474
94Granulocytopenia (HP:0001913)2.08354114
95Purpura (HP:0000979)2.08315012
96Epistaxis (HP:0000421)2.07865199
97Hemorrhage of the eye (HP:0011885)2.04688742
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04410538
99Aortic dissection (HP:0002647)2.03962481
100Arterial thrombosis (HP:0004420)2.03370756
101Pulmonary embolism (HP:0002204)2.03196197
102Abnormality of the 4th metacarpal (HP:0010012)2.02880066
103Abnormality of the lumbar spine (HP:0100712)2.02254796
104Spondylolisthesis (HP:0003302)2.01860239
105Prolonged bleeding time (HP:0003010)2.01840861
106Vascular tortuosity (HP:0004948)2.01757797
107Osteolytic defects of the hand bones (HP:0009699)2.00427272
108Osteolytic defects of the phalanges of the hand (HP:0009771)2.00427272
109Autoimmune thrombocytopenia (HP:0001973)1.98290160
110Keratoconjunctivitis sicca (HP:0001097)1.97515064
111Chronic otitis media (HP:0000389)1.96834451
112Pustule (HP:0200039)1.94480423
113Meningitis (HP:0001287)1.93118712
114Camptodactyly of toe (HP:0001836)1.92610854
115Abnormality of eosinophils (HP:0001879)1.92551573
116Amyloidosis (HP:0011034)1.92186290
117Abnormality of the pleura (HP:0002103)1.91802539
118Deep venous thrombosis (HP:0002625)1.91051741
119Hypoproteinemia (HP:0003075)1.90613395
120Bowing of the arm (HP:0006488)1.90523437
121Bowed forearm bones (HP:0003956)1.90523437
122Recurrent bronchitis (HP:0002837)1.88706745
123Abnormality of T cells (HP:0002843)1.88531744
124Cortical dysplasia (HP:0002539)1.88493271
125Abnormality of the peritoneum (HP:0002585)1.87664438
126Micronodular cirrhosis (HP:0001413)1.86654842
127Abnormality of T cell physiology (HP:0011840)1.86578287
128Complement deficiency (HP:0004431)1.86293236
129Systemic lupus erythematosus (HP:0002725)1.85129085
130Gingival bleeding (HP:0000225)1.85054465
131Visceral angiomatosis (HP:0100761)1.83911801
132Shallow orbits (HP:0000586)1.83694359
133Arthralgia (HP:0002829)1.83410042
134Lymphangioma (HP:0100764)1.82964586
135Hemangiomatosis (HP:0007461)1.82864372
136Neuronal loss in central nervous system (HP:0002529)1.82800330
137Viral hepatitis (HP:0006562)1.81819863
138Aneurysm (HP:0002617)1.81667719
139Polygenic inheritance (HP:0010982)1.80759562
140Premature loss of primary teeth (HP:0006323)1.80256251
141Recurrent bacterial skin infections (HP:0005406)1.80159230
142Polycythemia (HP:0001901)1.79709487
143Acrocyanosis (HP:0001063)1.79179191
144Pseudobulbar signs (HP:0002200)1.77836806
145Sepsis (HP:0100806)1.77729007
146Hallux valgus (HP:0001822)1.77287528
147Deviation of the hallux (HP:0010051)1.74886209
148Leukocytosis (HP:0001974)1.73020692
149Fatigue (HP:0012378)1.72774341
150Macroorchidism (HP:0000053)1.72742646
151Arnold-Chiari malformation (HP:0002308)1.71075161
152Broad metatarsal (HP:0001783)1.71021101
153Emphysema (HP:0002097)1.70423884
154Malignant gastrointestinal tract tumors (HP:0006749)1.70116702
155Gastrointestinal carcinoma (HP:0002672)1.70116702
156Renal duplication (HP:0000075)1.70101089
157Flattened epiphyses (HP:0003071)1.69435494
158Long eyelashes (HP:0000527)1.68760767
159Gastrointestinal stroma tumor (HP:0100723)1.67190386
160Periodontitis (HP:0000704)1.66879147
161Striae distensae (HP:0001065)1.66496086
162Limited elbow extension (HP:0001377)1.64925084
163Cutis marmorata (HP:0000965)1.64808777
164Glomerulonephritis (HP:0000099)1.64750484
165Elfin facies (HP:0004428)1.62671506
166Vertebral clefting (HP:0008428)1.62143720
167Ankle contracture (HP:0006466)1.59580557
168Eczematoid dermatitis (HP:0000976)1.58888270
169Back pain (HP:0003418)1.58643016
170Mitral regurgitation (HP:0001653)1.57353250
171Nephritis (HP:0000123)1.55965062
172Renovascular hypertension (HP:0100817)1.55159017
173Abnormality of the gastric mucosa (HP:0004295)1.54197498

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.14851016
2PRPF4B3.89140548
3RIPK43.71339037
4EEF2K2.76393978
5TRIB32.66217522
6TGFBR22.53391560
7PKN22.42366917
8ERN12.31122990
9SIK12.20716075
10CDK122.17942670
11IRAK42.11870705
12PTK62.11647430
13FGFR21.98619013
14LATS11.93752910
15MAP3K131.93405913
16STK101.90550025
17GRK61.84713412
18TYK21.82694270
19EPHB11.82491814
20CSF1R1.79184263
21SIK31.70956910
22IKBKE1.66048733
23LRRK21.65955419
24MAP4K11.64708615
25STK41.59725915
26SMG11.57368118
27TLK11.49543730
28FES1.44591112
29KIT1.42175137
30MATK1.34982520
31STK31.33824520
32RPS6KB21.33287268
33FRK1.33109726
34PAK41.32709685
35FGFR41.32515993
36CAMK1D1.32455886
37IRAK31.32261775
38FLT31.30768998
39FGR1.29192504
40MAP3K141.27677081
41PASK1.24780836
42CDC42BPA1.23139091
43ICK1.19300859
44CDK91.16583000
45CLK11.15387639
46CDK61.14600009
47TTN1.14013129
48FGFR31.10797035
49PDGFRB1.10655402
50MAP3K11.10439411
51ZAP701.08559038
52TNK21.08421959
53PDGFRA1.08209271
54MAP3K81.05757995
55MARK21.05142340
56CSK1.04614161
57MARK31.03919026
58CHUK1.03226020
59NME20.98506872
60MST40.98257529
61BRD40.96643988
62JAK10.96259921
63RIPK10.95348539
64BTK0.94788574
65TBK10.94160608
66DDR20.93217625
67IRAK20.91232879
68IRAK10.89897736
69IKBKB0.89846628
70PIM10.89379879
71TRPM70.89271954
72LMTK20.87441559
73EPHA30.86817876
74DYRK1B0.86638490
75ITK0.84354342
76JAK30.84121729
77CAMK1G0.83792819
78MAP2K20.83719437
79EPHA20.83443512
80CDK40.81882222
81MTOR0.81726679
82BMPR20.81554307
83TAOK10.81492717
84PRKD20.81466137
85MELK0.81228645
86NEK20.78918884
87TXK0.78619381
88MAP3K30.77474918
89RPS6KA40.74764438
90SGK30.74335562
91PDK10.73016650
92NLK0.71735477
93PDPK10.71007781
94MAP3K110.70490717
95WNK10.69942497
96STK240.66449916
97BMX0.66369771
98TAOK20.65163437
99HCK0.64292750
100JAK20.62932597
101RPS6KC10.62628712
102RPS6KL10.62628712
103SYK0.61648539
104MAPK70.61473570
105PRKD10.61106325
106CSNK1A1L0.60896144
107MAP3K70.59904290
108KSR20.58370573
109MAP2K30.57864869
110MAPK120.57853626
111TEC0.57517135
112SCYL20.56494176
113PAK20.56224914
114MAPK150.55613990
115SGK20.53893324
116INSR0.53729298
117PRKAA20.52632133
118NEK90.52253191
119BLK0.51314883
120LCK0.51286101
121PIK3CG0.50787513
122HIPK20.48842251
123TGFBR10.48301707
124MET0.47207587
125RPS6KA20.46816912
126GSK3A0.46332616
127EGFR0.45895905
128RPS6KA60.45549892
129DYRK30.44618597
130CDK190.43771130
131RET0.42927640
132TESK20.42109947
133PRKCQ0.42040164
134PKN10.41048030
135MAPKAPK20.40965529
136CSNK1D0.40040100
137MAPK110.39609419
138STK390.39217253
139TYRO30.37826615
140EPHB20.37428369
141CSNK1G10.36968481
142LYN0.36246357
143SIK20.35418958
144YES10.35118312

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053302.87404252
2Autoimmune thyroid disease_Homo sapiens_hsa053202.72469035
3Asthma_Homo sapiens_hsa053102.60473726
4B cell receptor signaling pathway_Homo sapiens_hsa046622.58759976
5Graft-versus-host disease_Homo sapiens_hsa053322.56020764
6Primary immunodeficiency_Homo sapiens_hsa053402.51983883
7Systemic lupus erythematosus_Homo sapiens_hsa053222.25632164
8Type I diabetes mellitus_Homo sapiens_hsa049402.07951665
9Chronic myeloid leukemia_Homo sapiens_hsa052202.07895050
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.90998183
11Small cell lung cancer_Homo sapiens_hsa052221.74509573
12Osteoclast differentiation_Homo sapiens_hsa043801.74371683
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.68986008
14Antigen processing and presentation_Homo sapiens_hsa046121.67760959
15Adherens junction_Homo sapiens_hsa045201.66283706
16Toxoplasmosis_Homo sapiens_hsa051451.63768467
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62528600
18Leishmaniasis_Homo sapiens_hsa051401.58036351
19Staphylococcus aureus infection_Homo sapiens_hsa051501.56517069
20Viral carcinogenesis_Homo sapiens_hsa052031.50498439
21Notch signaling pathway_Homo sapiens_hsa043301.41579628
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39740906
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.38167081
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.36229161
25Lysine degradation_Homo sapiens_hsa003101.35243550
26Pancreatic cancer_Homo sapiens_hsa052121.33063550
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27217692
28Rheumatoid arthritis_Homo sapiens_hsa053231.25848319
29Prostate cancer_Homo sapiens_hsa052151.24808004
30Proteoglycans in cancer_Homo sapiens_hsa052051.23432094
31Basal cell carcinoma_Homo sapiens_hsa052171.23238579
32Non-homologous end-joining_Homo sapiens_hsa034501.19667397
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18792042
34* MicroRNAs in cancer_Homo sapiens_hsa052061.17445293
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14920642
36Acute myeloid leukemia_Homo sapiens_hsa052211.13808299
37Hippo signaling pathway_Homo sapiens_hsa043901.12977319
38Non-small cell lung cancer_Homo sapiens_hsa052231.09399956
39Focal adhesion_Homo sapiens_hsa045101.08488535
40Apoptosis_Homo sapiens_hsa042101.08099644
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07926357
42HTLV-I infection_Homo sapiens_hsa051661.07625831
43T cell receptor signaling pathway_Homo sapiens_hsa046601.06217993
44Colorectal cancer_Homo sapiens_hsa052101.06141935
45Insulin resistance_Homo sapiens_hsa049311.06013421
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03448195
47Caffeine metabolism_Homo sapiens_hsa002321.02257063
48Endometrial cancer_Homo sapiens_hsa052131.00526779
49Measles_Homo sapiens_hsa051620.99358768
50Renal cell carcinoma_Homo sapiens_hsa052110.98608211
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98228009
52FoxO signaling pathway_Homo sapiens_hsa040680.95945116
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94870213
54Hematopoietic cell lineage_Homo sapiens_hsa046400.94673008
55Phagosome_Homo sapiens_hsa041450.94433233
56ECM-receptor interaction_Homo sapiens_hsa045120.94158854
57TNF signaling pathway_Homo sapiens_hsa046680.93376463
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92939900
59Nitrogen metabolism_Homo sapiens_hsa009100.92040210
60Complement and coagulation cascades_Homo sapiens_hsa046100.91434782
61Pathways in cancer_Homo sapiens_hsa052000.90038322
62Hepatitis B_Homo sapiens_hsa051610.88871683
63Chemokine signaling pathway_Homo sapiens_hsa040620.88769114
64Herpes simplex infection_Homo sapiens_hsa051680.86873653
65Viral myocarditis_Homo sapiens_hsa054160.86670222
66Platelet activation_Homo sapiens_hsa046110.85394953
67Legionellosis_Homo sapiens_hsa051340.84045873
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82562674
69mTOR signaling pathway_Homo sapiens_hsa041500.81500071
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80906297
71Influenza A_Homo sapiens_hsa051640.79621300
72TGF-beta signaling pathway_Homo sapiens_hsa043500.79473355
73Pertussis_Homo sapiens_hsa051330.74484129
74Shigellosis_Homo sapiens_hsa051310.73347221
75Amoebiasis_Homo sapiens_hsa051460.72994359
76Alcoholism_Homo sapiens_hsa050340.72475238
77Tuberculosis_Homo sapiens_hsa051520.72294029
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.72177762
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.71987680
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71848924
81Hepatitis C_Homo sapiens_hsa051600.70921124
82Bladder cancer_Homo sapiens_hsa052190.69627252
83Lysosome_Homo sapiens_hsa041420.68307806
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68299677
85Selenocompound metabolism_Homo sapiens_hsa004500.67190346
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65298105
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.65083532
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64566664
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64173615
90Other glycan degradation_Homo sapiens_hsa005110.63971314
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.63441114
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.62563751
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62482612
94Choline metabolism in cancer_Homo sapiens_hsa052310.61993108
95Epstein-Barr virus infection_Homo sapiens_hsa051690.61455543
96Salmonella infection_Homo sapiens_hsa051320.61330876
97Prolactin signaling pathway_Homo sapiens_hsa049170.61029246
98Tight junction_Homo sapiens_hsa045300.60754892
99Endocytosis_Homo sapiens_hsa041440.60234629
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59887727
101African trypanosomiasis_Homo sapiens_hsa051430.58754359
102ABC transporters_Homo sapiens_hsa020100.57918737
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57047496
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56924895
105HIF-1 signaling pathway_Homo sapiens_hsa040660.56091916
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55520911
107Glioma_Homo sapiens_hsa052140.54755928
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.53688738
109GnRH signaling pathway_Homo sapiens_hsa049120.53111578
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52665570
111Malaria_Homo sapiens_hsa051440.51736109
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50539145
113Fatty acid degradation_Homo sapiens_hsa000710.50177273
114Hedgehog signaling pathway_Homo sapiens_hsa043400.50058956
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49767030
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48105561
117AMPK signaling pathway_Homo sapiens_hsa041520.47542845
118Thyroid cancer_Homo sapiens_hsa052160.47539009
119Inositol phosphate metabolism_Homo sapiens_hsa005620.46832537
120VEGF signaling pathway_Homo sapiens_hsa043700.46446005
121Dorso-ventral axis formation_Homo sapiens_hsa043200.46150604
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46078607
123Type II diabetes mellitus_Homo sapiens_hsa049300.45911363
124Renin-angiotensin system_Homo sapiens_hsa046140.45821961
125ErbB signaling pathway_Homo sapiens_hsa040120.43433148
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43338314
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41197701
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.38463841
129MAPK signaling pathway_Homo sapiens_hsa040100.38460122
130Insulin signaling pathway_Homo sapiens_hsa049100.36607713
131Sphingolipid metabolism_Homo sapiens_hsa006000.31329810
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29555919

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