BMI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosome assembly (GO:0042255)8.67929993
2definitive hemopoiesis (GO:0060216)7.56425115
3urate metabolic process (GO:0046415)7.30825480
4monoubiquitinated protein deubiquitination (GO:0035520)7.04983495
5stress granule assembly (GO:0034063)6.72758034
6mitotic chromosome condensation (GO:0007076)6.26216763
7cellular response to arsenic-containing substance (GO:0071243)6.08589787
8regulation of sarcomere organization (GO:0060297)5.80194114
9positive regulation of translational initiation (GO:0045948)5.75058198
10cartilage morphogenesis (GO:0060536)5.72522199
11thyroid gland development (GO:0030878)5.36735217
12positive regulation of protein homodimerization activity (GO:0090073)5.30369836
13cranial nerve morphogenesis (GO:0021602)5.29740813
14mitotic sister chromatid cohesion (GO:0007064)5.28412836
15heart field specification (GO:0003128)5.17546607
16secondary heart field specification (GO:0003139)5.17546607
17histone H2B ubiquitination (GO:0033523)5.15234289
18embryonic viscerocranium morphogenesis (GO:0048703)5.13239894
19cell morphogenesis involved in neuron differentiation (GO:0048667)5.11968989
20mitotic metaphase plate congression (GO:0007080)5.03127706
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.02317124
22cellular response to antibiotic (GO:0071236)4.94185255
23regulation of RNA export from nucleus (GO:0046831)4.91388182
24cytoplasmic mRNA processing body assembly (GO:0033962)4.90771716
25germinal center formation (GO:0002467)4.89334533
26positive regulation of muscle hypertrophy (GO:0014742)4.88851156
27positive regulation of cardiac muscle hypertrophy (GO:0010613)4.88851156
28regulation of establishment of cell polarity (GO:2000114)4.88490413
29peptidyl-lysine dimethylation (GO:0018027)4.88391125
30regulation of sister chromatid cohesion (GO:0007063)4.88303847
31mitochondrion distribution (GO:0048311)4.83322706
32epithelial cell differentiation involved in kidney development (GO:0035850)4.81896500
33regulation of DNA endoreduplication (GO:0032875)4.72387296
34regulation of hippo signaling (GO:0035330)4.63617097
35mitochondrial genome maintenance (GO:0000002)4.61111602
36cardiac ventricle formation (GO:0003211)4.59900722
37negative regulation of erythrocyte differentiation (GO:0045647)4.56204010
38histone H2A monoubiquitination (GO:0035518)4.55075900
39cellular response to fluid shear stress (GO:0071498)4.54035116
40face development (GO:0060324)4.49413183
41sister chromatid cohesion (GO:0007062)4.46426956
42carnitine shuttle (GO:0006853)4.41572179
43response to vitamin E (GO:0033197)4.40705383
44DNA unwinding involved in DNA replication (GO:0006268)4.40553679
45protein localization to chromosome, centromeric region (GO:0071459)4.32262266
46positive regulation of mitotic sister chromatid separation (GO:1901970)4.23704515
47positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.23704515
48positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.23704515
49positive regulation of cell size (GO:0045793)4.23441224
50regulation of spindle organization (GO:0090224)4.18230866
51regulation of alkaline phosphatase activity (GO:0010692)4.17619716
52snRNA transcription (GO:0009301)4.16793316
53negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.16453814
54regulation of nucleobase-containing compound transport (GO:0032239)4.16386541
55cellular response to osmotic stress (GO:0071470)4.15319387
56metaphase plate congression (GO:0051310)4.14920016
57cardiac chamber formation (GO:0003207)4.13702729
58DNA damage induced protein phosphorylation (GO:0006975)4.13389650
59regulation of germinal center formation (GO:0002634)4.13148174
60DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.12870766
61attachment of spindle microtubules to kinetochore (GO:0008608)4.08305792
62positive regulation of cardiac muscle cell differentiation (GO:2000727)4.07655543
63corticosteroid receptor signaling pathway (GO:0031958)4.07389071
64regulation of establishment or maintenance of cell polarity (GO:0032878)4.05644087
65growth hormone receptor signaling pathway (GO:0060396)4.03716049
66ncRNA catabolic process (GO:0034661)4.00464442
67DNA damage response, signal transduction resulting in transcription (GO:0042772)3.94156197
68purine nucleobase metabolic process (GO:0006144)3.88205575
69protein localization to chromosome (GO:0034502)3.85968338
70regulation of meiosis I (GO:0060631)3.85471455
71protein localization to kinetochore (GO:0034501)3.85167433
72ribosomal large subunit biogenesis (GO:0042273)3.83447869
73regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.81101447
74carnitine transmembrane transport (GO:1902603)3.79476188
75nuclear pore complex assembly (GO:0051292)3.78057374
76regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.75623438
77myoblast migration (GO:0051451)3.74168338
78histone lysine demethylation (GO:0070076)3.73011051
79cardiac muscle adaptation (GO:0014887)3.68951891
80cardiac muscle hypertrophy in response to stress (GO:0014898)3.68951891
81muscle hypertrophy in response to stress (GO:0003299)3.68951891
82histone H3-K9 demethylation (GO:0033169)3.68478589
83melanocyte differentiation (GO:0030318)3.67307899
84piRNA metabolic process (GO:0034587)3.63925361
85positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)3.61769815
86fatty acid transmembrane transport (GO:1902001)3.57347912
87histone demethylation (GO:0016577)3.52429011
88histone H2A ubiquitination (GO:0033522)3.49445626
89positive regulation of chromosome segregation (GO:0051984)3.48590415
90dentate gyrus development (GO:0021542)3.46727584
91regulation of protein homodimerization activity (GO:0043496)3.46311090
92gonadal mesoderm development (GO:0007506)3.45513923
93cellular response to growth hormone stimulus (GO:0071378)3.44616898
94amino-acid betaine transport (GO:0015838)3.43305516
95carnitine transport (GO:0015879)3.43305516
96oocyte maturation (GO:0001556)3.41467385
97meiotic chromosome segregation (GO:0045132)3.41165141
98establishment of chromosome localization (GO:0051303)3.39928677
99regulation of cardiac muscle hypertrophy (GO:0010611)3.39676639
100chromosome condensation (GO:0030261)3.39391517
101cellular zinc ion homeostasis (GO:0006882)3.39379041
102female gamete generation (GO:0007292)3.38654225
103histone H3-K9 methylation (GO:0051567)3.37592763
104meiotic cell cycle (GO:0051321)3.37472504
105response to arsenic-containing substance (GO:0046685)3.36841290
106regulation of mitotic spindle organization (GO:0060236)3.36503615
107glycoprotein catabolic process (GO:0006516)3.34775279
108protein dealkylation (GO:0008214)3.34520790
109protein demethylation (GO:0006482)3.34520790
110regulation of muscle hypertrophy (GO:0014743)3.34428671
111mitotic sister chromatid segregation (GO:0000070)3.34014254
112microtubule nucleation (GO:0007020)3.33852635
113sister chromatid segregation (GO:0000819)3.32762579
114histone phosphorylation (GO:0016572)3.30984948
115cardiac myofibril assembly (GO:0055003)3.30722610
116regulation of clathrin-mediated endocytosis (GO:2000369)3.30458863
117muscle organ morphogenesis (GO:0048644)3.29653124
118negative regulation of circadian rhythm (GO:0042754)3.26829672
119response to UV-C (GO:0010225)3.26767574
120negative regulation of hormone biosynthetic process (GO:0032353)3.23816540
121negative regulation of hormone metabolic process (GO:0032351)3.23816540
122type B pancreatic cell development (GO:0003323)3.20947430
123nuclear pore organization (GO:0006999)3.19235222
124male meiosis (GO:0007140)3.15564343
125regulation of retinoic acid receptor signaling pathway (GO:0048385)3.15076815
126synaptonemal complex assembly (GO:0007130)3.13150018
127protein localization to endosome (GO:0036010)3.11231229
128male meiosis I (GO:0007141)3.10653844
129chromosome segregation (GO:0007059)3.10084822
130AMP metabolic process (GO:0046033)3.08389252
131positive regulation of cell cycle G1/S phase transition (GO:1902808)3.07462030
132monocyte differentiation (GO:0030224)3.07393958
133cellular response to toxic substance (GO:0097237)3.07045373
134pigment cell differentiation (GO:0050931)3.06705928
135gene silencing by RNA (GO:0031047)3.05893610
136regulation of meiosis (GO:0040020)3.02164943
137regulation of chromosome segregation (GO:0051983)3.01520650
138interkinetic nuclear migration (GO:0022027)3.01459674
139cellular response to gamma radiation (GO:0071480)3.00816352
140Golgi to endosome transport (GO:0006895)2.98997997
141regulation of histone H3-K9 methylation (GO:0051570)2.98130400
142kinetochore organization (GO:0051383)2.97879992
143histone H3-K9 modification (GO:0061647)2.96450135
144poly(A)+ mRNA export from nucleus (GO:0016973)2.96067365
145paraxial mesoderm development (GO:0048339)2.92737747
146glucocorticoid receptor signaling pathway (GO:0042921)2.92702844
147maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92612589
148histone H3-K36 demethylation (GO:0070544)2.90588312
149synaptonemal complex organization (GO:0070193)2.90304092
150specification of organ identity (GO:0010092)2.89973033
151regulation of cardiac muscle cell differentiation (GO:2000725)2.89435760
152meiosis I (GO:0007127)2.88307277
153chromatin assembly or disassembly (GO:0006333)2.87525513
154pentose-phosphate shunt (GO:0006098)2.86797491
155negative regulation of JUN kinase activity (GO:0043508)2.86120779
156cardiac muscle hypertrophy (GO:0003300)2.84455837
157DNA packaging (GO:0006323)2.83413616
158platelet formation (GO:0030220)2.83053303
159regulation of megakaryocyte differentiation (GO:0045652)2.82862620
160cytoskeleton-dependent cytokinesis (GO:0061640)2.81233581
161extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)2.80421979
162negative regulation of cell aging (GO:0090344)2.78632129
163regulation of cytokine production involved in inflammatory response (GO:1900015)2.78061474
164regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.77259636
165kinetochore assembly (GO:0051382)2.76836584
166positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.76168507
167regulation of exit from mitosis (GO:0007096)2.75888068
168mitotic nuclear envelope disassembly (GO:0007077)2.75229303
169intracellular lipid transport (GO:0032365)2.75052213
170androgen receptor signaling pathway (GO:0030521)2.74073300
171formation of translation preinitiation complex (GO:0001731)2.73874468
172N-terminal protein amino acid acetylation (GO:0006474)2.73158799
173regulation of muscle adaptation (GO:0043502)2.73097327
174resolution of meiotic recombination intermediates (GO:0000712)2.72842586
175regulation of keratinocyte proliferation (GO:0010837)2.71886601
176spindle checkpoint (GO:0031577)2.71345072
177striated muscle hypertrophy (GO:0014897)2.69573922
178DNA replication-independent nucleosome organization (GO:0034724)2.69497381
179DNA replication-independent nucleosome assembly (GO:0006336)2.69497381
180negative regulation of potassium ion transmembrane transport (GO:1901380)2.69133581
181regulation of histone H3-K27 methylation (GO:0061085)2.68289205
182regulation of transcription from RNA polymerase I promoter (GO:0006356)2.68253259
183myofibril assembly (GO:0030239)2.67886135
184microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.66391877
185regulation of transforming growth factor beta2 production (GO:0032909)2.66181814
186nuclear envelope disassembly (GO:0051081)2.65610454
187membrane disassembly (GO:0030397)2.65610454
188negative regulation of fibroblast apoptotic process (GO:2000270)2.63828951
189negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.63615007
190ubiquinone biosynthetic process (GO:0006744)2.60876235
191neuroepithelial cell differentiation (GO:0060563)2.51464151
192neuron remodeling (GO:0016322)2.50338057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.89325698
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.14524899
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.87033439
4E2F7_22180533_ChIP-Seq_HELA_Human3.75429735
5ESR1_15608294_ChIP-ChIP_MCF-7_Human3.64368440
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.55802972
7AR_21909140_ChIP-Seq_LNCAP_Human3.02021498
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93054244
9TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.86531689
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.72941776
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.71395502
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.64785587
13* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.63069619
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.34429898
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21550017
16PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.15350902
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.14634269
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.11880131
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09937761
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.09429986
21* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.02559501
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01949335
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96086980
24SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.93229453
25RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.92385846
26* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91192708
27* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.89738565
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.85979602
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84849375
30SCL_19346495_ChIP-Seq_HPC-7_Human1.78832468
31PKCTHETA_26484144_Chip-Seq_BREAST_Human1.74131357
32KAP1_22055183_ChIP-Seq_ESCs_Mouse1.67568266
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.66280031
34FUS_26573619_Chip-Seq_HEK293_Human1.63155221
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57525560
36FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.56283731
37DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55066383
38GBX2_23144817_ChIP-Seq_PC3_Human1.53109919
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52160655
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49009701
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.48667689
42IGF1R_20145208_ChIP-Seq_DFB_Human1.48473233
43* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42670541
44ELK1_19687146_ChIP-ChIP_HELA_Human1.40901620
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40311259
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40088564
47TP53_16413492_ChIP-PET_HCT116_Human1.32864912
48FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.32613560
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31535405
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31319472
51RUNX1_26923725_Chip-Seq_HPCs_Mouse1.30018874
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29909110
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27764578
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.26095335
55TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25125295
56BRD4_25478319_ChIP-Seq_HGPS_Human1.24730845
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24665662
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24617618
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.23158696
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22319597
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22319597
62SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.22033221
63AR_21572438_ChIP-Seq_LNCaP_Human1.20611827
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20443204
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19268442
66MYC_22102868_ChIP-Seq_BL_Human1.19064888
67FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.17624664
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17460901
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17013680
70MYB_26560356_Chip-Seq_TH2_Human1.16843637
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.15495756
72TFEB_21752829_ChIP-Seq_HELA_Human1.14891312
73* TCF7_22412390_ChIP-Seq_EML_Mouse1.13946480
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13911421
75STAT3_23295773_ChIP-Seq_U87_Human1.13533276
76GATA1_22025678_ChIP-Seq_K562_Human1.13367969
77* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.13316704
78TBL1_22424771_ChIP-Seq_293T_Human1.12856139
79* UBF1/2_26484160_Chip-Seq_HMECs_Human1.11732614
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09981498
81FOXA1_25552417_ChIP-Seq_VCAP_Human1.09335446
82CHD1_26751641_Chip-Seq_LNCaP_Human1.07929595
83ER_23166858_ChIP-Seq_MCF-7_Human1.06267169
84ATF3_27146783_Chip-Seq_COLON_Human1.05908208
85CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05615569
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05599724
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04704891
88CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04485360
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04266901
90* NANOG_21062744_ChIP-ChIP_HESCs_Human1.04139660
91* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03945005
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03668418
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03614883
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03074292
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03074292
96MYB_26560356_Chip-Seq_TH1_Human1.02643650
97PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02564834
98CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02264518
99LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01997828
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01307655
101ETS1_22383799_ChIP-Seq_G1ME_Mouse1.01152244
102KDM5A_27292631_Chip-Seq_BREAST_Human1.00677899
103ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98498901
104SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98129671
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97845866
106CDX2_22108803_ChIP-Seq_LS180_Human0.97724165
107NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97358372
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97358372
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.97027144
110SMAD4_21799915_ChIP-Seq_A2780_Human0.96938866
111TCF4_18268006_ChIP-ChIP_LS174T_Human0.96791268
112NFYA_21822215_ChIP-Seq_K562_Human0.95029995
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94423266
114EWS_26573619_Chip-Seq_HEK293_Human0.94016368
115CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93951595
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93851286
117MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93662189
118CJUN_26792858_Chip-Seq_BT549_Human0.93415946
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92887407
120* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91990966
121DCP1A_22483619_ChIP-Seq_HELA_Human0.91506184
122* KDM2B_26808549_Chip-Seq_DND41_Human0.90666304
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90169701
124ISL1_27105846_Chip-Seq_CPCs_Mouse0.89552534
125CLOCK_20551151_ChIP-Seq_293T_Human0.89318372
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88767298
127NANOG_18555785_Chip-Seq_ESCs_Mouse0.88691536
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87981244
129* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87883714
130CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87465090
131E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87032830
132EGR1_19374776_ChIP-ChIP_THP-1_Human0.86520567
133TAL1_26923725_Chip-Seq_HPCs_Mouse0.85799861
134TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84448746
135ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84258859
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83643399
137FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.83102243
138WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82338815
139TP63_23658742_ChIP-Seq_EP156T_Human0.82119961
140ELF5_23300383_ChIP-Seq_T47D_Human0.81792754
141GF1B_26923725_Chip-Seq_HPCs_Mouse0.81563950
142VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81560517
143ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80069214

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.04029411
2MP0000681_abnormal_thyroid_gland3.66515900
3MP0000015_abnormal_ear_pigmentation3.34577834
4MP0004185_abnormal_adipocyte_glucose3.31054639
5MP0005451_abnormal_body_composition3.21471200
6MP0002166_altered_tumor_susceptibility2.97467303
7MP0004084_abnormal_cardiac_muscle2.91847451
8MP0005409_darkened_coat_color2.82457283
9MP0005408_hypopigmentation2.80290463
10MP0003172_abnormal_lysosome_physiology2.74726220
11MP0005174_abnormal_tail_pigmentation2.73881772
12MP0008877_abnormal_DNA_methylation2.70897659
13MP0002837_dystrophic_cardiac_calcinosis2.33749407
14MP0003693_abnormal_embryo_hatching2.29142072
15* MP0003077_abnormal_cell_cycle2.26815184
16MP0002102_abnormal_ear_morphology2.26471053
17MP0005076_abnormal_cell_differentiation2.21573985
18MP0010307_abnormal_tumor_latency2.20078633
19MP0002249_abnormal_larynx_morphology2.14647002
20MP0005670_abnormal_white_adipose2.12751926
21MP0003111_abnormal_nucleus_morphology2.11735292
22MP0008057_abnormal_DNA_replication2.08353794
23MP0010094_abnormal_chromosome_stability2.04140040
24MP0003787_abnormal_imprinting2.02773415
25MP0003705_abnormal_hypodermis_morpholog1.99638148
26MP0004264_abnormal_extraembryonic_tissu1.98501060
27MP0002653_abnormal_ependyma_morphology1.97702389
28MP0001849_ear_inflammation1.97322573
29MP0004036_abnormal_muscle_relaxation1.94560735
30MP0005187_abnormal_penis_morphology1.90230373
31MP0003718_maternal_effect1.82629456
32MP0002084_abnormal_developmental_patter1.81947156
33MP0004782_abnormal_surfactant_physiolog1.80208823
34MP0003221_abnormal_cardiomyocyte_apopto1.80146634
35* MP0000350_abnormal_cell_proliferation1.74322321
36MP0003890_abnormal_embryonic-extraembry1.71196134
37MP0004957_abnormal_blastocyst_morpholog1.70164095
38MP0001697_abnormal_embryo_size1.69288221
39MP0002971_abnormal_brown_adipose1.69099354
40MP0005380_embryogenesis_phenotype1.67955793
41MP0001672_abnormal_embryogenesis/_devel1.67955793
42MP0001929_abnormal_gametogenesis1.65912090
43MP0003646_muscle_fatigue1.65097911
44* MP0001730_embryonic_growth_arrest1.64495470
45* MP0003937_abnormal_limbs/digits/tail_de1.63286476
46MP0002009_preneoplasia1.60577050
47MP0005666_abnormal_adipose_tissue1.57523182
48MP0000733_abnormal_muscle_development1.56522557
49MP0003984_embryonic_growth_retardation1.53776886
50* MP0002085_abnormal_embryonic_tissue1.52097467
51MP0002088_abnormal_embryonic_growth/wei1.50157530
52MP0003699_abnormal_female_reproductive1.49952661
53MP0002210_abnormal_sex_determination1.49569964
54MP0003959_abnormal_lean_body1.48320921
55MP0002160_abnormal_reproductive_system1.45503976
56MP0010234_abnormal_vibrissa_follicle1.44122224
57MP0010368_abnormal_lymphatic_system1.41333287
58* MP0003763_abnormal_thymus_physiology1.41070728
59MP0009780_abnormal_chondrocyte_physiolo1.40521427
60MP0001299_abnormal_eye_distance/1.38151135
61MP0005266_abnormal_metabolism1.36948842
62MP0001119_abnormal_female_reproductive1.36326216
63MP0004233_abnormal_muscle_weight1.35995898
64MP0000653_abnormal_sex_gland1.34498997
65MP0001346_abnormal_lacrimal_gland1.33705208
66MP0003183_abnormal_peptide_metabolism1.33358229
67MP0005535_abnormal_body_temperature1.31530789
68MP0000013_abnormal_adipose_tissue1.29356250
69MP0008995_early_reproductive_senescence1.29228981
70MP0003300_gastrointestinal_ulcer1.29034677
71MP0008961_abnormal_basal_metabolism1.27972491
72MP0005464_abnormal_platelet_physiology1.27927660
73MP0002086_abnormal_extraembryonic_tissu1.27885280
74MP0002095_abnormal_skin_pigmentation1.23398005
75MP0009384_cardiac_valve_regurgitation1.22418162
76MP0000428_abnormal_craniofacial_morphol1.21307216
77MP0001873_stomach_inflammation1.19312652
78MP0005248_abnormal_Harderian_gland1.18540652
79MP0009697_abnormal_copulation1.18439599
80* MP0003935_abnormal_craniofacial_develop1.16268524
81MP0000003_abnormal_adipose_tissue1.15795675
82MP0006138_congestive_heart_failure1.15293891
83MP0002177_abnormal_outer_ear1.14422623
84MP0001502_abnormal_circadian_rhythm1.13962134
85MP0003121_genomic_imprinting1.13094416
86MP0005395_other_phenotype1.12376742
87MP0009672_abnormal_birth_weight1.12274646
88MP0001145_abnormal_male_reproductive1.12177417
89MP0003385_abnormal_body_wall1.09779861
90MP0004808_abnormal_hematopoietic_stem1.09459099
91MP0003656_abnormal_erythrocyte_physiolo1.09106989
92MP0005257_abnormal_intraocular_pressure1.07816616
93MP0001915_intracranial_hemorrhage1.07643513
94MP0005375_adipose_tissue_phenotype1.07467660
95MP0000432_abnormal_head_morphology1.07309454
96MP0010352_gastrointestinal_tract_polyps1.07305641
97MP0000566_synostosis1.07268712
98* MP0003755_abnormal_palate_morphology1.06363810
99MP0000639_abnormal_adrenal_gland1.05736883
100MP0004134_abnormal_chest_morphology1.05525776
101MP0009115_abnormal_fat_cell1.02832208
102* MP0008007_abnormal_cellular_replicative1.01033931
103MP0003091_abnormal_cell_migration1.00623194
104MP0004885_abnormal_endolymph0.99937566
105MP0001851_eye_inflammation0.99247696
106MP0002108_abnormal_muscle_morphology0.98880296
107MP0003123_paternal_imprinting0.97224871
108* MP0002080_prenatal_lethality0.95992349
109MP0003567_abnormal_fetal_cardiomyocyte0.95021682
110MP0000371_diluted_coat_color0.94769425
111MP0003950_abnormal_plasma_membrane0.93983098
112MP0002161_abnormal_fertility/fecundity0.92699448
113MP0000537_abnormal_urethra_morphology0.92336092
114MP0003868_abnormal_feces_composition0.91777702
115MP0009703_decreased_birth_body0.91479365
116MP0001545_abnormal_hematopoietic_system0.90107831
117MP0005397_hematopoietic_system_phenotyp0.90107831
118MP0001764_abnormal_homeostasis0.90038274
119MP0003315_abnormal_perineum_morphology0.89239855
120MP0001348_abnormal_lacrimal_gland0.87775741
121MP0005058_abnormal_lysosome_morphology0.87656048
122MP0003191_abnormal_cellular_cholesterol0.87586400
123MP0006292_abnormal_olfactory_placode0.86919699
124MP0000767_abnormal_smooth_muscle0.86611428
125MP0003115_abnormal_respiratory_system0.84664823
126MP0000462_abnormal_digestive_system0.83489910
127MP0000569_abnormal_digit_pigmentation0.82691342
128MP0003045_fibrosis0.82657884
129MP0005621_abnormal_cell_physiology0.82563841
130MP0002396_abnormal_hematopoietic_system0.81726574
131MP0002233_abnormal_nose_morphology0.81569965
132MP0002006_tumorigenesis0.80807393
133* MP0002925_abnormal_cardiovascular_devel0.80692755
134MP0003698_abnormal_male_reproductive0.79984922
135MP0003943_abnormal_hepatobiliary_system0.79891099
136MP0005220_abnormal_exocrine_pancreas0.79655253
137MP0005310_abnormal_salivary_gland0.79129111
138MP0003329_amyloid_beta_deposits0.77710008
139MP0001664_abnormal_digestion0.77643116
140MP0002932_abnormal_joint_morphology0.77206657
141MP0000627_abnormal_mammary_gland0.76984978
142MP0003453_abnormal_keratinocyte_physiol0.75737958
143* MP0003861_abnormal_nervous_system0.75128726
144MP0003828_pulmonary_edema0.75087232
145MP0003252_abnormal_bile_duct0.74873440
146MP0000678_abnormal_parathyroid_gland0.73383174
147MP0002269_muscular_atrophy0.70609059
148MP0005623_abnormal_meninges_morphology0.69772545
149MP0008569_lethality_at_weaning0.69770357
150MP0009379_abnormal_foot_pigmentation0.64675929
151MP0003806_abnormal_nucleotide_metabolis0.64500716
152MP0002970_abnormal_white_adipose0.63226462
153MP0004087_abnormal_muscle_fiber0.62309110
154MP0005334_abnormal_fat_pad0.58841104
155MP0000759_abnormal_skeletal_muscle0.58836091
156MP0000534_abnormal_ureter_morphology0.56693988
157MP0010155_abnormal_intestine_physiology0.56567258
158MP0002060_abnormal_skin_morphology0.55083404
159MP0002928_abnormal_bile_duct0.54986218
160MP0010630_abnormal_cardiac_muscle0.54894999
161* MP0000703_abnormal_thymus_morphology0.54642469
162MP0001340_abnormal_eyelid_morphology0.54443367
163MP0001765_abnormal_ion_homeostasis0.53945896
164MP0001944_abnormal_pancreas_morphology0.53509520
165MP0000598_abnormal_liver_morphology0.53508409
166MP0000470_abnormal_stomach_morphology0.53314820

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the intrinsic pathway (HP:0010989)6.58111083
2Papillary thyroid carcinoma (HP:0002895)6.31038635
3Facial hemangioma (HP:0000329)5.28530074
4Reduced antithrombin III activity (HP:0001976)5.12281593
5Male infertility (HP:0003251)4.96443214
6Ankyloglossia (HP:0010296)4.62940030
7Capillary hemangiomas (HP:0005306)4.03571952
8Broad face (HP:0000283)3.98873004
9Volvulus (HP:0002580)3.96745151
10Rhabdomyolysis (HP:0003201)3.83749250
11Abnormality of oral frenula (HP:0000190)3.78093433
12Myoglobinuria (HP:0002913)3.73150306
13Thyroid carcinoma (HP:0002890)3.67542324
14J-shaped sella turcica (HP:0002680)3.48367178
15Acute myeloid leukemia (HP:0004808)3.38812740
16Abnormality of the fingertips (HP:0001211)3.15055720
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.13369658
18Absent/shortened dynein arms (HP:0200106)3.13369658
19Menstrual irregularities (HP:0000858)3.11203690
20Microglossia (HP:0000171)3.09521185
21Metaphyseal dysplasia (HP:0100255)3.06475638
22Cheilitis (HP:0100825)3.03080170
23Fatigue (HP:0012378)3.01243129
24Spinal canal stenosis (HP:0003416)2.98414265
25Periodontitis (HP:0000704)2.98347439
26Polycythemia (HP:0001901)2.98105239
27Shawl scrotum (HP:0000049)2.97522627
28Spontaneous abortion (HP:0005268)2.94185086
29Amniotic constriction ring (HP:0009775)2.93738828
30Abnormality of placental membranes (HP:0011409)2.93738828
31Central scotoma (HP:0000603)2.92719400
32Xerostomia (HP:0000217)2.91149536
33Enlarged penis (HP:0000040)2.90130928
34Subacute progressive viral hepatitis (HP:0006572)2.87649943
35Exercise-induced myalgia (HP:0003738)2.86585050
36Osteomalacia (HP:0002749)2.79780118
37Lip pit (HP:0100267)2.77025727
38Horizontal nystagmus (HP:0000666)2.76119008
39Cortical dysplasia (HP:0002539)2.73644699
40Obstructive sleep apnea (HP:0002870)2.72729783
41Oligodactyly (hands) (HP:0001180)2.71782781
42Trismus (HP:0000211)2.71730560
43Autoimmune hemolytic anemia (HP:0001890)2.71717113
44Heterotopia (HP:0002282)2.65870787
45Prostate neoplasm (HP:0100787)2.62362371
46Oligodactyly (HP:0012165)2.61225860
47Cervical subluxation (HP:0003308)2.57003427
48Myocardial infarction (HP:0001658)2.55619358
49Deep philtrum (HP:0002002)2.52482319
50Peritonitis (HP:0002586)2.50909154
51Pustule (HP:0200039)2.50767662
52Posterior subcapsular cataract (HP:0007787)2.46141088
53Sandal gap (HP:0001852)2.41800295
54Type I transferrin isoform profile (HP:0003642)2.37135129
55Abnormality of chromosome segregation (HP:0002916)2.36721029
56Ridged nail (HP:0001807)2.36304434
57Dysmetric saccades (HP:0000641)2.35215556
58Poikiloderma (HP:0001029)2.33356836
59Abnormality of the gastric mucosa (HP:0004295)2.31623774
60Transitional cell carcinoma of the bladder (HP:0006740)2.29680182
61Patellar aplasia (HP:0006443)2.28814983
62Hyperglycemia (HP:0003074)2.28156081
63Termporal pattern (HP:0011008)2.27171214
64Insidious onset (HP:0003587)2.27171214
65Truncal obesity (HP:0001956)2.25202930
66Hyperkalemia (HP:0002153)2.25023243
67Deviation of the thumb (HP:0009603)2.24277001
68Insulin-resistant diabetes mellitus (HP:0000831)2.23744820
69Sparse lateral eyebrow (HP:0005338)2.23304014
70Proximal placement of thumb (HP:0009623)2.21746695
71Sensorimotor neuropathy (HP:0007141)2.21154001
72Abnormality of chromosome stability (HP:0003220)2.20160324
73Ankle contracture (HP:0006466)2.19551467
74Long eyelashes (HP:0000527)2.19445372
75Abnormality of the preputium (HP:0100587)2.18338229
76Abnormal biliary tract morphology (HP:0012440)2.12992586
77Biconcave vertebral bodies (HP:0004586)2.10989539
78Gastrointestinal infarctions (HP:0005244)2.10952436
79Gastrointestinal inflammation (HP:0004386)2.10571723
80Gingival bleeding (HP:0000225)2.10495339
81Deformed sella turcica (HP:0002681)2.09594922
82Inflammation of the large intestine (HP:0002037)2.09545168
83Aplasia/Hypoplasia of the patella (HP:0006498)2.08876766
84Overlapping toe (HP:0001845)2.08450113
85Thoracolumbar scoliosis (HP:0002944)2.08438346
86Short 4th metacarpal (HP:0010044)2.08152453
87Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.08152453
88Bladder carcinoma (HP:0002862)2.06836467
89Bladder neoplasm (HP:0009725)2.06836467
90Shallow orbits (HP:0000586)2.05947291
91Chromsome breakage (HP:0040012)2.04607070
92Arterial tortuosity (HP:0005116)2.03314485
93Birth length less than 3rd percentile (HP:0003561)2.02517525
94Asymmetry of the thorax (HP:0001555)2.01501315
95Adrenal hypoplasia (HP:0000835)2.01283822
96Fragile skin (HP:0001030)2.01064165
97Scotoma (HP:0000575)2.00147353
98Abnormality of lateral ventricle (HP:0030047)1.98460052
99Subcapsular cataract (HP:0000523)1.97518499
100Anterior segment dysgenesis (HP:0007700)1.96747327
101Abnormality of the labia minora (HP:0012880)1.96318797
102Mitral regurgitation (HP:0001653)1.94338322
103Cystic hygroma (HP:0000476)1.93658135
104Palpitations (HP:0001962)1.93151426
105Thick eyebrow (HP:0000574)1.92531209
106Prominent nose (HP:0000448)1.92094033
107Exostoses (HP:0100777)1.91630997
108Bell-shaped thorax (HP:0001591)1.91258773
109Tetraplegia (HP:0002445)1.91039149
110Poor eye contact (HP:0000817)1.90860711
111Lower limb hyperreflexia (HP:0002395)1.89951679
112Genetic anticipation (HP:0003743)1.89056568
113Hypercortisolism (HP:0001578)1.86715478
114Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.86260930
115Cafe-au-lait spot (HP:0000957)1.85977053
116Low anterior hairline (HP:0000294)1.85951468
117Abnormality of macular pigmentation (HP:0008002)1.85725397
118Ectopic kidney (HP:0000086)1.85046072
119Complete atrioventricular canal defect (HP:0001674)1.84234304
120Neuroendocrine neoplasm (HP:0100634)1.82185974
121Wrist flexion contracture (HP:0001239)1.81854555
122Aortic regurgitation (HP:0001659)1.81558285
123Vascular tortuosity (HP:0004948)1.81348002
124Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.80380609
125Long clavicles (HP:0000890)1.80350394
126Albinism (HP:0001022)1.80141933
127Atrioventricular block (HP:0001678)1.79480457
128Abnormal protein N-linked glycosylation (HP:0012347)1.79267271
129Abnormal protein glycosylation (HP:0012346)1.79267271
130Abnormal glycosylation (HP:0012345)1.79267271
131Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79267271
132Venous abnormality (HP:0002624)1.79051492
133Hyporeflexia of lower limbs (HP:0002600)1.78724901
134Bundle branch block (HP:0011710)1.78592416
135Myelodysplasia (HP:0002863)1.78254089
136Abnormal ciliary motility (HP:0012262)1.77886495
137Subaortic stenosis (HP:0001682)1.77572092
138Abnormality of the left ventricular outflow tract (HP:0011103)1.77572092
139Abnormality of salivation (HP:0100755)1.77409251
140Large earlobe (HP:0009748)1.77244895
141Abnormal hemoglobin (HP:0011902)1.76157175
142Abnormality of the 4th metacarpal (HP:0010012)1.76026060
143Acute lymphatic leukemia (HP:0006721)1.74915872
144Submucous cleft hard palate (HP:0000176)1.74126854
145Neoplasm of the thyroid gland (HP:0100031)1.72751390
146Exocrine pancreatic insufficiency (HP:0001738)1.71311001
147Arteriovenous malformation (HP:0100026)1.70852063
148Azoospermia (HP:0000027)1.70817194
149Long toe (HP:0010511)1.70731659
150Aneurysm (HP:0002617)1.69728977
151Macroorchidism (HP:0000053)1.68755139
152Abnormal foot bone ossification (HP:0010675)1.68201193
153Abnormal spermatogenesis (HP:0008669)1.67703743
154Disinhibition (HP:0000734)1.66607662
155Chorioretinal atrophy (HP:0000533)1.66592845
156Smooth philtrum (HP:0000319)1.66446149
157Leiomyosarcoma (HP:0100243)1.66136771
158Uterine leiomyosarcoma (HP:0002891)1.66136771
159Aortic valve stenosis (HP:0001650)1.65226516
160Neoplasm of the oral cavity (HP:0100649)1.64878212
161Narrow palate (HP:0000189)1.64192222
162Primary amenorrhea (HP:0000786)1.63299925
163Cubitus valgus (HP:0002967)1.62062767
164Neonatal respiratory distress (HP:0002643)1.61887152
165Glucose intolerance (HP:0000833)1.61493296
166Hyperparathyroidism (HP:0000843)1.61308694
167Curly hair (HP:0002212)1.61045173
168Broad thumb (HP:0011304)1.60423820
169Aplasia/Hypoplasia of the sternum (HP:0006714)1.60353384
170Thickened calvaria (HP:0002684)1.60321522
171Cerebral aneurysm (HP:0004944)1.60057726
172Blepharitis (HP:0000498)1.59855683
173Aplasia/Hypoplasia of the uvula (HP:0010293)1.59378452
174Striae distensae (HP:0001065)1.59107034
175Camptodactyly of toe (HP:0001836)1.57140231
176Aortic aneurysm (HP:0004942)1.56299488
177Increased nuchal translucency (HP:0010880)1.55128252
178Hypoplastic labia majora (HP:0000059)1.54877691
179Abnormality of the line of Schwalbe (HP:0008048)1.54227787
180Breast aplasia (HP:0100783)1.52912480
181Chromosomal breakage induced by crosslinking agents (HP:0003221)1.52814103
182Entropion (HP:0000621)1.52083646
183Hypochromic microcytic anemia (HP:0004840)1.52075353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS17.46121850
2LATS25.10077030
3STK38L4.49894758
4SCYL23.72830610
5EIF2AK33.12707197
6CDC73.09990750
7MAP3K62.85523940
8MAP3K132.82827982
9STK32.74518316
10MAP3K142.54506454
11IRAK22.44319544
12PNCK2.33879607
13MAPK122.27135541
14TRIB32.19602795
15TAOK12.14359135
16KSR22.08310859
17TAOK32.04248536
18PASK1.98814370
19NEK21.94554398
20ERBB31.94336057
21MAPK71.89209987
22PRKD31.88960265
23YES11.88597990
24ERBB41.84963972
25TYRO31.84813577
26CAMKK21.80363000
27BCKDK1.72743723
28STK381.71623936
29RPS6KB21.63152323
30FRK1.60792665
31RPS6KB11.60568445
32PDGFRA1.57318594
33PAK61.55968426
34PHKG11.55593440
35PHKG21.55593440
36IRAK11.53297751
37RAF11.50069326
38CHEK21.49287410
39CDK121.44325814
40CSF1R1.43292482
41CDK91.41088944
42SYK1.37555003
43PBK1.34849464
44ABL21.32814315
45PDGFRB1.31212589
46PRPF4B1.30522251
47EEF2K1.29932073
48DMPK1.27635196
49CAMK1D1.27139635
50MELK1.26350667
51PKN21.25616425
52TAF11.24290592
53TRPM71.23301387
54CDK81.22744297
55NTRK31.22027375
56PLK41.21002180
57MAP3K71.19173296
58VRK11.16536543
59CAMKK11.11799766
60DYRK31.11717401
61DYRK21.11715047
62RET1.11486992
63WNK11.11113758
64WEE11.07267988
65EIF2AK11.07106385
66ACVR1B1.05886809
67CLK11.05594945
68KSR11.04430495
69BRSK21.04041725
70MST1R1.01309766
71TNK20.98699162
72JAK30.95775614
73BMPR20.95705722
74TTK0.93279396
75CAMK1G0.91839561
76GRK60.87566608
77NEK10.86563917
78EIF2AK20.85079316
79PRKAA10.84665290
80INSRR0.83475487
81FGFR20.83417950
82HIPK20.82976062
83MOS0.82408768
84CSNK1G10.81941218
85PRKD20.80216120
86MAP3K40.79738884
87AKT20.79670210
88CSNK1G20.74919857
89BRD40.71672123
90MAP3K90.70960394
91CHEK10.70529931
92KIT0.69433409
93AURKB0.68179884
94NEK60.67624007
95PIK3CG0.66756488
96CDK60.66631050
97CDK40.65103026
98MAP3K50.64629597
99SGK30.64446299
100PLK10.64402027
101ATM0.62542989
102OBSCN0.62260572
103MAP2K10.62157938
104STK390.61582183
105ABL10.60868785
106FGFR30.60646818
107MUSK0.60582339
108AKT30.60503249
109IGF1R0.60483808
110CDK30.60425839
111DDR20.58351117
112MAP2K40.56781399
113PRKAA20.55876434
114CCNB10.55144279
115IRAK30.55030506
116MAP2K30.53921482
117PRKDC0.52407624
118HCK0.51256258
119STK100.49546755
120NUAK10.46510477
121MARK20.46192965
122MTOR0.44722607
123RPS6KA40.44239232
124STK40.44109348
125PRKCE0.44058893
126MAPK100.42996628
127SRPK10.42407030
128ICK0.42123712
129PDK40.40665711
130PDK30.40665711
131PRKCH0.39367346
132CDK20.38957049
133JAK20.38357006
134EPHA30.38194156
135BRSK10.38098708
136MAP3K80.37951217
137MAPK130.37568133
138WNK40.36667646
139CSNK1A1L0.36295727
140MARK30.35984012
141STK240.35318746
142CDK10.34708500
143TTN0.34195655
144NTRK20.33993110
145CSNK1G30.32414172
146GSK3B0.32378556
147UHMK10.32259208
148PAK30.30927285
149CDK70.28489804
150PLK30.28330217
151PAK20.28068864
152CSNK1D0.27921565
153NEK90.24001438
154PTK20.23644275
155ILK0.23536004
156MAPK140.21732799
157PTK60.21515992
158MAPK110.20465254
159PRKD10.19716009
160MAP3K20.18092225
161ATR0.17978639

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001305.02004789
2Cell cycle_Homo sapiens_hsa041102.95184921
3Selenocompound metabolism_Homo sapiens_hsa004502.61321569
4Pancreatic cancer_Homo sapiens_hsa052122.38448698
5Circadian rhythm_Homo sapiens_hsa047102.27729777
6Basal transcription factors_Homo sapiens_hsa030222.18354657
7Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.16760720
8N-Glycan biosynthesis_Homo sapiens_hsa005102.09292876
9p53 signaling pathway_Homo sapiens_hsa041151.95895122
10TGF-beta signaling pathway_Homo sapiens_hsa043501.92385246
11mTOR signaling pathway_Homo sapiens_hsa041501.91643280
12Dorso-ventral axis formation_Homo sapiens_hsa043201.89520412
13RNA degradation_Homo sapiens_hsa030181.88152320
14Renal cell carcinoma_Homo sapiens_hsa052111.87723073
15Prolactin signaling pathway_Homo sapiens_hsa049171.79753814
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74550532
17Oocyte meiosis_Homo sapiens_hsa041141.73932477
18* MicroRNAs in cancer_Homo sapiens_hsa052061.71336838
19Chronic myeloid leukemia_Homo sapiens_hsa052201.65172266
20Vitamin B6 metabolism_Homo sapiens_hsa007501.58301187
21mRNA surveillance pathway_Homo sapiens_hsa030151.58086739
22Renin secretion_Homo sapiens_hsa049241.57760597
23Lysine degradation_Homo sapiens_hsa003101.57653289
24Adherens junction_Homo sapiens_hsa045201.54484560
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51167585
26Colorectal cancer_Homo sapiens_hsa052101.51098240
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50632742
28Ovarian steroidogenesis_Homo sapiens_hsa049131.50014706
29Endometrial cancer_Homo sapiens_hsa052131.43633532
30Non-small cell lung cancer_Homo sapiens_hsa052231.43467965
31FoxO signaling pathway_Homo sapiens_hsa040681.35141687
32VEGF signaling pathway_Homo sapiens_hsa043701.34561004
33RNA transport_Homo sapiens_hsa030131.32411387
34Longevity regulating pathway - mammal_Homo sapiens_hsa042111.31264059
35Choline metabolism in cancer_Homo sapiens_hsa052311.30170267
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.29576670
37Small cell lung cancer_Homo sapiens_hsa052221.29562651
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28618727
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28551196
40B cell receptor signaling pathway_Homo sapiens_hsa046621.24826803
41Prostate cancer_Homo sapiens_hsa052151.20681257
42Glioma_Homo sapiens_hsa052141.19572251
43Acute myeloid leukemia_Homo sapiens_hsa052211.18683482
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14783126
45Hippo signaling pathway_Homo sapiens_hsa043901.13559087
46Thyroid cancer_Homo sapiens_hsa052161.10717535
47Viral myocarditis_Homo sapiens_hsa054161.08661153
48AMPK signaling pathway_Homo sapiens_hsa041521.08348059
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07067038
50* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06077359
51T cell receptor signaling pathway_Homo sapiens_hsa046601.04875517
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03228920
53ErbB signaling pathway_Homo sapiens_hsa040121.02760885
54Insulin resistance_Homo sapiens_hsa049311.02577288
55Long-term depression_Homo sapiens_hsa047300.99714865
56Fanconi anemia pathway_Homo sapiens_hsa034600.99461272
57GnRH signaling pathway_Homo sapiens_hsa049120.98209169
58Bladder cancer_Homo sapiens_hsa052190.97043208
59Pentose phosphate pathway_Homo sapiens_hsa000300.95116488
60Regulation of autophagy_Homo sapiens_hsa041400.93347917
61Focal adhesion_Homo sapiens_hsa045100.91353653
62Hepatitis B_Homo sapiens_hsa051610.90561405
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90092282
64Herpes simplex infection_Homo sapiens_hsa051680.89447180
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.87076595
66Proteoglycans in cancer_Homo sapiens_hsa052050.86647944
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.86206917
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86001037
69Purine metabolism_Homo sapiens_hsa002300.85395705
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84420026
71Pancreatic secretion_Homo sapiens_hsa049720.80924892
72Platelet activation_Homo sapiens_hsa046110.79460635
73Melanoma_Homo sapiens_hsa052180.79330511
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76936919
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76786173
76MAPK signaling pathway_Homo sapiens_hsa040100.76595919
77Ras signaling pathway_Homo sapiens_hsa040140.75875445
78Insulin signaling pathway_Homo sapiens_hsa049100.74344602
79Insulin secretion_Homo sapiens_hsa049110.73621036
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73442543
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72871129
82Glucagon signaling pathway_Homo sapiens_hsa049220.72787188
83Viral carcinogenesis_Homo sapiens_hsa052030.72779821
84Estrogen signaling pathway_Homo sapiens_hsa049150.72484189
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71622810
86HTLV-I infection_Homo sapiens_hsa051660.71600281
87Wnt signaling pathway_Homo sapiens_hsa043100.69321147
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.68623937
89Shigellosis_Homo sapiens_hsa051310.66980691
90Amphetamine addiction_Homo sapiens_hsa050310.66456169
91Inositol phosphate metabolism_Homo sapiens_hsa005620.66146866
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.64855303
93African trypanosomiasis_Homo sapiens_hsa051430.64608298
94Type II diabetes mellitus_Homo sapiens_hsa049300.64215741
95Calcium signaling pathway_Homo sapiens_hsa040200.63721719
96Pathways in cancer_Homo sapiens_hsa052000.63383415
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62719690
98Alcoholism_Homo sapiens_hsa050340.62596352
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61634953
100Tight junction_Homo sapiens_hsa045300.61169767
101Chemokine signaling pathway_Homo sapiens_hsa040620.60882255
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.60877387
103ABC transporters_Homo sapiens_hsa020100.60836556
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.60301573
105Cholinergic synapse_Homo sapiens_hsa047250.60011896
106Oxytocin signaling pathway_Homo sapiens_hsa049210.59516480
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.59450085
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58637777
109Measles_Homo sapiens_hsa051620.57716922
110cAMP signaling pathway_Homo sapiens_hsa040240.57563365
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55414489
112Toxoplasmosis_Homo sapiens_hsa051450.54585914
113Nucleotide excision repair_Homo sapiens_hsa034200.54488220
114RNA polymerase_Homo sapiens_hsa030200.53945509
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53730500
116Linoleic acid metabolism_Homo sapiens_hsa005910.53505673
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53416578
118* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52953977
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52644561
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52432886
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51833171
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.51660821
123Ether lipid metabolism_Homo sapiens_hsa005650.50196947
124Rap1 signaling pathway_Homo sapiens_hsa040150.49284992
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48457598
126Nitrogen metabolism_Homo sapiens_hsa009100.47158197
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46651221
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46257320
129Notch signaling pathway_Homo sapiens_hsa043300.46233212
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45682590
131Long-term potentiation_Homo sapiens_hsa047200.45441767
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.45439365
133Circadian entrainment_Homo sapiens_hsa047130.44319568
134Hedgehog signaling pathway_Homo sapiens_hsa043400.42665610
135TNF signaling pathway_Homo sapiens_hsa046680.42459686
136Homologous recombination_Homo sapiens_hsa034400.42179998
137Endocytosis_Homo sapiens_hsa041440.41817925

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