BMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.50239519
2negative regulation of fibrinolysis (GO:0051918)4.58211859
3L-phenylalanine catabolic process (GO:0006559)4.53128095
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.53128095
5cell-substrate junction assembly (GO:0007044)4.47216361
6L-phenylalanine metabolic process (GO:0006558)4.26341342
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.26341342
8regulation of fibrinolysis (GO:0051917)4.21185342
9protein carboxylation (GO:0018214)3.98384794
10peptidyl-glutamic acid carboxylation (GO:0017187)3.98384794
11wound healing, spreading of epidermal cells (GO:0035313)3.95977241
12vascular endothelial growth factor signaling pathway (GO:0038084)3.95787231
13extracellular fibril organization (GO:0043206)3.94391875
14cell migration involved in heart development (GO:0060973)3.86032485
15negative regulation of chondrocyte differentiation (GO:0032331)3.79489549
16collagen fibril organization (GO:0030199)3.77351172
17alpha-linolenic acid metabolic process (GO:0036109)3.75299810
18desmosome organization (GO:0002934)3.67369544
19aromatic amino acid family catabolic process (GO:0009074)3.64155617
20regulation of plasminogen activation (GO:0010755)3.63801312
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.59822993
22type B pancreatic cell proliferation (GO:0044342)3.59639030
23protein heterotrimerization (GO:0070208)3.56200541
24substrate-dependent cell migration (GO:0006929)3.52070725
25regulation of protein activation cascade (GO:2000257)3.51884397
26Golgi transport vesicle coating (GO:0048200)3.50819115
27COPI coating of Golgi vesicle (GO:0048205)3.50819115
28positive regulation of fatty acid beta-oxidation (GO:0032000)3.47102251
29fibril organization (GO:0097435)3.46738858
30kidney mesenchyme development (GO:0072074)3.42878472
31glomerular basement membrane development (GO:0032836)3.42393609
32bile acid biosynthetic process (GO:0006699)3.42246011
33glyoxylate metabolic process (GO:0046487)3.40712162
34protein retention in ER lumen (GO:0006621)3.39300226
35regulation of complement activation (GO:0030449)3.34122089
36positive regulation of blood vessel endothelial cell migration (GO:0043536)3.34016334
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.33498580
38skin morphogenesis (GO:0043589)3.32543155
39regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.30850874
40vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.28307074
41extracellular matrix assembly (GO:0085029)3.27900938
42epoxygenase P450 pathway (GO:0019373)3.26202983
43midgut development (GO:0007494)3.25696298
44peptidyl-proline hydroxylation (GO:0019511)3.23116356
45fibrinolysis (GO:0042730)3.22504357
46high-density lipoprotein particle remodeling (GO:0034375)3.22350973
47* extracellular matrix organization (GO:0030198)3.21668835
48planar cell polarity pathway involved in neural tube closure (GO:0090179)3.21444180
49* extracellular structure organization (GO:0043062)3.20392988
50complement activation, alternative pathway (GO:0006957)3.19373784
51metanephric mesenchyme development (GO:0072075)3.19350863
52wound healing, spreading of cells (GO:0044319)3.19230407
53renal filtration (GO:0097205)3.17528930
54sulfur amino acid catabolic process (GO:0000098)3.17141113
55regulation of cholesterol homeostasis (GO:2000188)3.16167079
56positive regulation of osteoblast proliferation (GO:0033690)3.14039321
57adhesion of symbiont to host cell (GO:0044650)3.10603309
58virion attachment to host cell (GO:0019062)3.10603309
59endodermal cell differentiation (GO:0035987)3.07435559
60regulation of apoptotic process involved in morphogenesis (GO:1902337)3.06541422
61dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.04684575
62adherens junction assembly (GO:0034333)3.02352387
63kynurenine metabolic process (GO:0070189)3.02298232
64cellular response to vitamin (GO:0071295)3.02155262
65semaphorin-plexin signaling pathway (GO:0071526)3.00712753
66plasma lipoprotein particle clearance (GO:0034381)3.00234479
67protein localization to endosome (GO:0036010)2.99610772
68negative regulation of smooth muscle cell migration (GO:0014912)2.98071710
69heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.98012632
70retina vasculature morphogenesis in camera-type eye (GO:0061299)2.97308575
71bone trabecula formation (GO:0060346)2.97073008
72regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.96936842
73atrioventricular valve morphogenesis (GO:0003181)2.96529132
74regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.96196530
75barbed-end actin filament capping (GO:0051016)2.96190793
76chondrocyte proliferation (GO:0035988)2.96095727
77negative regulation of protein activation cascade (GO:2000258)2.96000007
78positive regulation of endothelial cell apoptotic process (GO:2000353)2.95552472
79mesodermal cell differentiation (GO:0048333)2.95339352
80apoptotic cell clearance (GO:0043277)2.94957206
81glial cell migration (GO:0008347)2.94704089
82adhesion of symbiont to host (GO:0044406)2.93380390
83reverse cholesterol transport (GO:0043691)2.93380037
84venous blood vessel morphogenesis (GO:0048845)2.92944476
85substrate adhesion-dependent cell spreading (GO:0034446)2.92681933
86regulation of fatty acid beta-oxidation (GO:0031998)2.92387579
87dermatan sulfate metabolic process (GO:0030205)2.91781554
88focal adhesion assembly (GO:0048041)2.91007268
89cell-substrate adherens junction assembly (GO:0007045)2.91007268
90bile acid metabolic process (GO:0008206)2.89921067
91negative regulation of cartilage development (GO:0061037)2.89423056
92chondroitin sulfate biosynthetic process (GO:0030206)2.88828018
93cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.87519244
94indole-containing compound catabolic process (GO:0042436)2.87088283
95indolalkylamine catabolic process (GO:0046218)2.87088283
96tryptophan catabolic process (GO:0006569)2.87088283
97neuron projection extension involved in neuron projection guidance (GO:1902284)2.86984747
98axon extension involved in axon guidance (GO:0048846)2.86984747
99regulation of triglyceride catabolic process (GO:0010896)2.86531932
100urea cycle (GO:0000050)2.86380177
101urea metabolic process (GO:0019627)2.86380177
102cysteine metabolic process (GO:0006534)2.85335324
103protein hydroxylation (GO:0018126)2.83852598
104epithelial cell-cell adhesion (GO:0090136)2.83170887
105stress fiber assembly (GO:0043149)2.82698329
106triglyceride homeostasis (GO:0070328)2.82082090
107acylglycerol homeostasis (GO:0055090)2.82082090
108opsonization (GO:0008228)2.81195121
109actin filament depolymerization (GO:0030042)2.80611415
110positive regulation of fatty acid oxidation (GO:0046321)2.80086314
111keratan sulfate catabolic process (GO:0042340)2.76866877
112tyrosine metabolic process (GO:0006570)2.76354365
113tryptophan metabolic process (GO:0006568)2.74763874
114collagen metabolic process (GO:0032963)2.74117611
115negative regulation of axon extension involved in axon guidance (GO:0048843)2.72003977
116dermatan sulfate biosynthetic process (GO:0030208)2.71331218
117lymphangiogenesis (GO:0001946)2.69168369
118collagen catabolic process (GO:0030574)2.68768405
119lysine metabolic process (GO:0006553)2.68707042
120lysine catabolic process (GO:0006554)2.68707042
121mesenchymal-epithelial cell signaling (GO:0060638)2.65850442
122cellular response to vitamin D (GO:0071305)2.64872567
123smooth muscle tissue development (GO:0048745)2.64206900
124protein-lipid complex remodeling (GO:0034368)2.63396180
125macromolecular complex remodeling (GO:0034367)2.63396180
126plasma lipoprotein particle remodeling (GO:0034369)2.63396180
127positive regulation of lipid catabolic process (GO:0050996)2.63148979
128homocysteine metabolic process (GO:0050667)2.63065678
129cell adhesion mediated by integrin (GO:0033627)2.62808473
130fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.62437673
131cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.61486127
132cholesterol efflux (GO:0033344)2.60896227
133chondrocyte development (GO:0002063)2.60530701
134regulation of extracellular matrix disassembly (GO:0010715)2.60397490
135nitrogen cycle metabolic process (GO:0071941)2.60146361
136coenzyme catabolic process (GO:0009109)2.59695420
137multicellular organismal macromolecule metabolic process (GO:0044259)2.59027487
138negative regulation of fatty acid transport (GO:2000192)2.58485061
139regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.58149362
140hyaluronan catabolic process (GO:0030214)2.57901750
141extracellular negative regulation of signal transduction (GO:1900116)2.57380885
142extracellular regulation of signal transduction (GO:1900115)2.57380885
143negative regulation of cholesterol transport (GO:0032375)2.57174288
144negative regulation of sterol transport (GO:0032372)2.57174288
145cellular glucuronidation (GO:0052695)2.56289992
146cell-matrix adhesion (GO:0007160)2.55798986
147cellular modified amino acid catabolic process (GO:0042219)2.55631870
148positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.54435289
149cell-substrate adhesion (GO:0031589)2.53609943
150Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.52677645
151positive regulation of glycogen biosynthetic process (GO:0045725)2.52375105
152negative regulation of complement activation (GO:0045916)2.51824381
153regulation of cholesterol esterification (GO:0010872)2.50743451
154positive regulation of fatty acid biosynthetic process (GO:0045723)2.50485031
155cellular ketone body metabolic process (GO:0046950)2.49908457
156multicellular organismal catabolic process (GO:0044243)2.48622787
157multicellular organismal metabolic process (GO:0044236)2.48212341
158negative regulation of lipase activity (GO:0060192)2.47671249
159aromatic amino acid family metabolic process (GO:0009072)2.46423757
160glutamate metabolic process (GO:0006536)2.46259216
161basement membrane organization (GO:0071711)2.45242323
162* extracellular matrix disassembly (GO:0022617)2.44203093
163positive regulation of fatty acid metabolic process (GO:0045923)2.44179522
164amino-acid betaine metabolic process (GO:0006577)2.42968730
1654-hydroxyproline metabolic process (GO:0019471)2.40759294
166phospholipid efflux (GO:0033700)2.38020249
167negative regulation of lipid transport (GO:0032369)2.36146389
168endothelial cell morphogenesis (GO:0001886)2.36134401
169tooth mineralization (GO:0034505)2.35968098
170sequestering of extracellular ligand from receptor (GO:0035581)2.35601782
171positive regulation of glycogen metabolic process (GO:0070875)2.35225076
172alpha-amino acid catabolic process (GO:1901606)2.34903168
173cholesterol homeostasis (GO:0042632)2.34825229
174* lipoprotein metabolic process (GO:0042157)2.31898371
175positive regulation of blood coagulation (GO:0030194)2.31324562
176positive regulation of hemostasis (GO:1900048)2.31324562
177sterol homeostasis (GO:0055092)2.31298054
178regulation of bile acid biosynthetic process (GO:0070857)2.30170201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.54279320
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.03000882
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.79409848
4* LXR_22158963_ChIP-Seq_LIVER_Mouse3.46667534
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.34859522
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.00635155
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.99366602
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.67878051
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.63130870
10CLOCK_20551151_ChIP-Seq_293T_Human2.60313628
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.57022733
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.53589714
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.19804512
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.05236346
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.05220198
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.00075538
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.75898159
18SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.75524815
19SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.75524815
20TP53_22127205_ChIP-Seq_IMR90_Human1.73215966
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.72409098
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70449417
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.67884455
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64963497
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63880314
26ZNF263_19887448_ChIP-Seq_K562_Human1.62363172
27P63_26484246_Chip-Seq_KERATINOCYTES_Human1.62315709
28* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60993931
29* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60993931
30UBF1/2_26484160_Chip-Seq_HMECs_Human1.60639570
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.60512431
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57948588
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57543230
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56299809
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.52121330
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.52121330
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50742592
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49263437
39EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47520182
40JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46221522
41* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44735938
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44521889
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44380326
44FOXA2_19822575_ChIP-Seq_HepG2_Human1.44012533
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41812362
46CJUN_26792858_Chip-Seq_BT549_Human1.40546446
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.39530122
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.38212513
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37888229
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37773365
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.36206275
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34911571
53* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34211980
54* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.33961901
55JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33298878
56* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33117218
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.32016160
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31359179
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30500871
60ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.30002550
61* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29038000
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26386749
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25592568
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25258753
65CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22560933
66* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21893971
67ATF3_27146783_Chip-Seq_COLON_Human1.21290277
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20933780
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.17790092
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16165238
71DROSHA_22980978_ChIP-Seq_HELA_Human1.15791395
72* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.15207693
73* SA1_22415368_ChIP-Seq_MEFs_Mouse1.14874284
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13888200
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.13869352
76* EZH2_27294783_Chip-Seq_ESCs_Mouse1.13778773
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.13091526
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12660111
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10026832
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09866665
81KDM2B_26808549_Chip-Seq_K562_Human1.09632364
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08778088
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08346823
84TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.06798928
85* TET1_21490601_ChIP-Seq_MESCs_Mouse1.06794030
86* TBX20_22080862_ChIP-Seq_HEART_Mouse1.05720894
87* TBX20_22328084_ChIP-Seq_HEART_Mouse1.05720894
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04804629
89LXR_22292898_ChIP-Seq_THP-1_Human1.04340061
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03715447
91EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03711045
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03100546
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03098500
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02653258
95TP53_16413492_ChIP-PET_HCT116_Human1.01923628
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.01891544
97* EZH2_27304074_Chip-Seq_ESCs_Mouse1.01850050
98SOX2_20726797_ChIP-Seq_SW620_Human1.01636270
99SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00979932
100TP63_22573176_ChIP-Seq_HFKS_Human1.00590837
101* RNF2_27304074_Chip-Seq_ESCs_Mouse0.99845873
102SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99673803
103NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99588143
104* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99345825
105SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98222187
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97778583
107* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96489059
108BRD4_25478319_ChIP-Seq_HGPS_Human0.95944677
109CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95463475
110TP53_18474530_ChIP-ChIP_U2OS_Human0.95220119
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95106014
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95039964
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94678439
114KDM2B_26808549_Chip-Seq_DND41_Human0.93495033
115SA1_27219007_Chip-Seq_ERYTHROID_Human0.92270237
116RACK7_27058665_Chip-Seq_MCF-7_Human0.92250398
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91985576
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90570967
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89924406
120SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89796113
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89447697
122ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89102796
123ELK3_25401928_ChIP-Seq_HUVEC_Human0.88828694
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.86413581
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85973858
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85952008
127* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84588890
128AHR_22903824_ChIP-Seq_MCF-7_Human0.83960525
129* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.83862836
130GATA2_21666600_ChIP-Seq_HMVEC_Human0.82650118
131SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82608874
132KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81015434
133HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80483175
134RING1B_27294783_Chip-Seq_ESCs_Mouse0.79833608
135RING1B_27294783_Chip-Seq_NPCs_Mouse0.78652616
136TP53_23651856_ChIP-Seq_MEFs_Mouse0.76827942
137AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76402238
138SMAD4_21741376_ChIP-Seq_HESCs_Human0.75772118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.20296970
2MP0002139_abnormal_hepatobiliary_system4.02376742
3MP0005275_abnormal_skin_tensile3.88547836
4MP0005503_abnormal_tendon_morphology3.67681632
5MP0003705_abnormal_hypodermis_morpholog3.64897178
6MP0005360_urolithiasis3.35994073
7MP0005085_abnormal_gallbladder_physiolo3.09037794
8MP0005365_abnormal_bile_salt2.84909480
9MP0003252_abnormal_bile_duct2.63630227
10MP0003279_aneurysm2.51306446
11MP0004272_abnormal_basement_membrane2.34862144
12MP0009384_cardiac_valve_regurgitation2.33125852
13MP0005083_abnormal_biliary_tract2.15754585
14MP0008875_abnormal_xenobiotic_pharmacok2.10215402
15MP0001958_emphysema2.04395309
16MP0003195_calcinosis1.99097638
17MP0005623_abnormal_meninges_morphology1.95473915
18MP0003950_abnormal_plasma_membrane1.80629468
19MP0010329_abnormal_lipoprotein_level1.79301409
20MP0010368_abnormal_lymphatic_system1.75037020
21MP0002295_abnormal_pulmonary_circulatio1.72737141
22MP0009840_abnormal_foam_cell1.71287132
23MP0009053_abnormal_anal_canal1.70994378
24MP0001849_ear_inflammation1.69034773
25MP0002877_abnormal_melanocyte_morpholog1.68894606
26MP0002060_abnormal_skin_morphology1.64636908
27MP0005257_abnormal_intraocular_pressure1.63261744
28MP0003806_abnormal_nucleotide_metabolis1.62472308
29MP0009780_abnormal_chondrocyte_physiolo1.58791148
30MP0003283_abnormal_digestive_organ1.50582732
31MP0002896_abnormal_bone_mineralization1.48857772
32MP0005508_abnormal_skeleton_morphology1.47594890
33MP0006054_spinal_hemorrhage1.47566550
34MP0005409_darkened_coat_color1.46426321
35MP0003941_abnormal_skin_development1.43380589
36MP0002108_abnormal_muscle_morphology1.37092886
37MP0005058_abnormal_lysosome_morphology1.34167304
38MP0005023_abnormal_wound_healing1.28827087
39MP0001299_abnormal_eye_distance/1.26545297
40MP0001879_abnormal_lymphatic_vessel1.25171052
41MP0001243_abnormal_dermal_layer1.24417659
42MP0010030_abnormal_orbit_morphology1.22115594
43MP0003566_abnormal_cell_adhesion1.21800393
44MP0001666_abnormal_nutrient_absorption1.21192876
45MP0000013_abnormal_adipose_tissue1.17274223
46MP0009250_abnormal_appendicular_skeleto1.17217117
47MP0005332_abnormal_amino_acid1.17029236
48MP0003115_abnormal_respiratory_system1.16514497
49MP0002118_abnormal_lipid_homeostasis1.15702711
50MP0000534_abnormal_ureter_morphology1.15014841
51MP0003300_gastrointestinal_ulcer1.13087852
52MP0003942_abnormal_urinary_system1.10159926
53MP0000462_abnormal_digestive_system1.06670150
54* MP0003385_abnormal_body_wall1.06147540
55MP0002168_other_aberrant_phenotype1.06087333
56MP0003453_abnormal_keratinocyte_physiol1.05921853
57MP0003091_abnormal_cell_migration1.05738838
58MP0005220_abnormal_exocrine_pancreas1.05091912
59MP0010352_gastrointestinal_tract_polyps1.01587588
60MP0002282_abnormal_trachea_morphology1.00935235
61MP0000579_abnormal_nail_morphology0.99784481
62MP0000163_abnormal_cartilage_morphology0.99479236
63MP0000733_abnormal_muscle_development0.99413154
64MP0001542_abnormal_bone_strength0.98824413
65MP0003329_amyloid_beta_deposits0.98251365
66MP0000751_myopathy0.97968815
67MP0005197_abnormal_uvea_morphology0.97327219
68MP0005164_abnormal_response_to0.96095957
69MP0002932_abnormal_joint_morphology0.95192602
70MP0003868_abnormal_feces_composition0.95143438
71MP0000767_abnormal_smooth_muscle0.93549530
72MP0001915_intracranial_hemorrhage0.92554428
73MP0000537_abnormal_urethra_morphology0.92478656
74MP0005171_absent_coat_pigmentation0.91269339
75MP0000467_abnormal_esophagus_morphology0.90208640
76MP0000003_abnormal_adipose_tissue0.87344048
77MP0002837_dystrophic_cardiac_calcinosis0.86958662
78MP0002115_abnormal_skeleton_extremities0.86430440
79MP0000609_abnormal_liver_physiology0.86236081
80MP0000750_abnormal_muscle_regeneration0.85882756
81MP0003045_fibrosis0.84191809
82MP0000759_abnormal_skeletal_muscle0.83333042
83MP0000428_abnormal_craniofacial_morphol0.83150132
84* MP0001614_abnormal_blood_vessel0.81389798
85MP0010771_integument_phenotype0.81015763
86MP0002254_reproductive_system_inflammat0.80595519
87MP0005165_increased_susceptibility_to0.80221518
88MP0003448_altered_tumor_morphology0.80147402
89MP0004134_abnormal_chest_morphology0.78729857
90MP0004233_abnormal_muscle_weight0.78255386
91MP0002249_abnormal_larynx_morphology0.77892026
92MP0001177_atelectasis0.75909911
93MP0000538_abnormal_urinary_bladder0.75669376
94MP0005193_abnormal_anterior_eye0.74937740
95MP0003191_abnormal_cellular_cholesterol0.73590549
96MP0005595_abnormal_vascular_smooth0.73016464
97MP0002128_abnormal_blood_circulation0.72293845
98MP0000762_abnormal_tongue_morphology0.71650402
99MP0002998_abnormal_bone_remodeling0.71596849
100MP0005076_abnormal_cell_differentiation0.71024818
101MP0000858_altered_metastatic_potential0.70118467
102MP0000604_amyloidosis0.69483893
103MP0004185_abnormal_adipocyte_glucose0.68878301
104MP0000566_synostosis0.68870900
105MP0002089_abnormal_postnatal_growth/wei0.68802377
106MP0005375_adipose_tissue_phenotype0.68050864
107MP0002234_abnormal_pharynx_morphology0.67284888
108MP0001216_abnormal_epidermal_layer0.67012228
109MP0000749_muscle_degeneration0.66975587
110MP0004858_abnormal_nervous_system0.64721473
111MP0001348_abnormal_lacrimal_gland0.64307252
112MP0000343_altered_response_to0.63895603
113MP0003755_abnormal_palate_morphology0.63835826
114MP0000678_abnormal_parathyroid_gland0.63436909
115MP0001661_extended_life_span0.62188571
116MP0004087_abnormal_muscle_fiber0.61795170
117MP0003937_abnormal_limbs/digits/tail_de0.61340115
118MP0002925_abnormal_cardiovascular_devel0.61181674
119MP0005390_skeleton_phenotype0.60621619
120MP0005330_cardiomyopathy0.60476386
121MP0005319_abnormal_enzyme/_coenzyme0.60148108
122MP0004084_abnormal_cardiac_muscle0.59976216
123MP0001533_abnormal_skeleton_physiology0.59758871
124MP0005187_abnormal_penis_morphology0.59527070
125MP0002233_abnormal_nose_morphology0.59443449
126MP0000432_abnormal_head_morphology0.59028162
127MP0003795_abnormal_bone_structure0.58357633
128MP0003690_abnormal_glial_cell0.58200086
129MP0001340_abnormal_eyelid_morphology0.58149438
130MP0003935_abnormal_craniofacial_develop0.57607383
131MP0000747_muscle_weakness0.57547847
132MP0005388_respiratory_system_phenotype0.57152027
133MP0002133_abnormal_respiratory_system0.57152027
134MP0005666_abnormal_adipose_tissue0.56925075
135MP0001944_abnormal_pancreas_morphology0.56778567
136MP0002933_joint_inflammation0.56232489
137MP0002697_abnormal_eye_size0.56156727
138MP0002113_abnormal_skeleton_development0.56095918

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.29090827
2Premature rupture of membranes (HP:0001788)6.08333760
3Deep venous thrombosis (HP:0002625)4.71963800
4Broad metatarsal (HP:0001783)4.30018449
5Shallow orbits (HP:0000586)4.14492322
6Peritonitis (HP:0002586)3.98191893
7Atrophic scars (HP:0001075)3.90144672
8Intrahepatic cholestasis (HP:0001406)3.69940129
9Xanthomatosis (HP:0000991)3.57670246
10Aortic dissection (HP:0002647)3.54906263
11Ankle contracture (HP:0006466)3.41858164
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.27697958
13Soft skin (HP:0000977)3.21066063
14Bladder diverticulum (HP:0000015)3.15591636
15Fragile skin (HP:0001030)3.12126330
16Spondylolisthesis (HP:0003302)3.05606476
17Cerebral aneurysm (HP:0004944)3.05398816
18Abnormality of monocarboxylic acid metabolism (HP:0010996)2.98899950
19Abnormality of dentin (HP:0010299)2.91706614
20Mitral valve prolapse (HP:0001634)2.89747738
21Turricephaly (HP:0000262)2.83841493
22Infantile muscular hypotonia (HP:0008947)2.76518963
23Aortic regurgitation (HP:0001659)2.76223769
24Hyperlipoproteinemia (HP:0010980)2.75022527
25Follicular hyperkeratosis (HP:0007502)2.74759121
26Prolonged partial thromboplastin time (HP:0003645)2.72833537
27Coronal craniosynostosis (HP:0004440)2.65901960
28Type 1 muscle fiber predominance (HP:0003803)2.65311131
29Abnormality of the common coagulation pathway (HP:0010990)2.63629439
30Mitral regurgitation (HP:0001653)2.62950444
31Complement deficiency (HP:0004431)2.59175635
32* Blue sclerae (HP:0000592)2.58206974
33Hypobetalipoproteinemia (HP:0003563)2.57991868
34Spinal rigidity (HP:0003306)2.56399224
35Joint stiffness (HP:0001387)2.54163186
36Dilatation of the ascending aorta (HP:0005111)2.54002752
37Mitral stenosis (HP:0001718)2.53845670
38Buphthalmos (HP:0000557)2.50444844
39Short nail (HP:0001799)2.49353508
40Aortic aneurysm (HP:0004942)2.48518617
41Biconcave vertebral bodies (HP:0004586)2.47128942
42Skin nodule (HP:0200036)2.47016911
43Ectopia lentis (HP:0001083)2.45410812
44Abnormal delivery (HP:0001787)2.45055431
45Neonatal short-limb short stature (HP:0008921)2.40216934
46Hypoalphalipoproteinemia (HP:0003233)2.37930373
47Natal tooth (HP:0000695)2.37170276
48Wide anterior fontanel (HP:0000260)2.33876773
49Hyperextensible skin (HP:0000974)2.33313027
50Osteolytic defects of the phalanges of the hand (HP:0009771)2.31791235
51Osteolytic defects of the hand bones (HP:0009699)2.31791235
52Genu recurvatum (HP:0002816)2.30030433
53Milia (HP:0001056)2.30014406
54Abnormality of the intrinsic pathway (HP:0010989)2.27903078
55Hypolipoproteinemia (HP:0010981)2.27578189
56Aneurysm (HP:0002617)2.26991833
57Epidermoid cyst (HP:0200040)2.24277960
58Wrist flexion contracture (HP:0001239)2.24123839
59Cervical subluxation (HP:0003308)2.22293859
60Aortic valve stenosis (HP:0001650)2.21219925
61Broad face (HP:0000283)2.19307855
62Increased variability in muscle fiber diameter (HP:0003557)2.18858410
63Hypoglycemic coma (HP:0001325)2.18401628
64* Wormian bones (HP:0002645)2.16420603
65Increased connective tissue (HP:0009025)2.15684430
66Overgrowth (HP:0001548)2.12436610
67Ulnar bowing (HP:0003031)2.11317561
68Vertebral compression fractures (HP:0002953)2.11260046
69Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.06293915
70Ketosis (HP:0001946)2.04915722
71Upper limb amyotrophy (HP:0009129)2.04870704
72Distal upper limb amyotrophy (HP:0007149)2.04870704
73Mildly elevated creatine phosphokinase (HP:0008180)2.04398679
74Bronchomalacia (HP:0002780)2.03853018
75Deviation of the hallux (HP:0010051)2.02996856
76Cardiovascular calcification (HP:0011915)2.02600741
77Venous abnormality (HP:0002624)2.01668166
78Back pain (HP:0003418)2.00529868
79Hyperacusis (HP:0010780)2.00096323
80Lymphangioma (HP:0100764)1.99454966
81Congenital glaucoma (HP:0001087)1.99423198
82Abnormality of glutamine family amino acid metabolism (HP:0010902)1.98835790
83Abnormality of the Achilles tendon (HP:0005109)1.96639585
84Osteoarthritis (HP:0002758)1.96024201
85Hallux valgus (HP:0001822)1.94524815
86Myocardial infarction (HP:0001658)1.94293865
87Venous insufficiency (HP:0005293)1.93709784
88Vascular tortuosity (HP:0004948)1.91563831
89Fragile nails (HP:0001808)1.91309985
90Hypoplasia of the iris (HP:0007676)1.89918994
91Bowel diverticulosis (HP:0005222)1.89445475
92Abnormality of complement system (HP:0005339)1.88820093
93Right ventricular cardiomyopathy (HP:0011663)1.87801370
94Thin bony cortex (HP:0002753)1.86081772
95Neurofibrillary tangles (HP:0002185)1.85537178
96Inguinal hernia (HP:0000023)1.84767914
97Renal duplication (HP:0000075)1.83739584
98Femoral bowing (HP:0002980)1.83380790
99Slender build (HP:0001533)1.83195618
100Bowing of the arm (HP:0006488)1.82344869
101Bowed forearm bones (HP:0003956)1.82344869
102Nonimmune hydrops fetalis (HP:0001790)1.82282008
103Flat cornea (HP:0007720)1.81679506
104Bell-shaped thorax (HP:0001591)1.81631114
105Alopecia of scalp (HP:0002293)1.80894480
106Pulmonary artery stenosis (HP:0004415)1.80156157
107Generalized amyotrophy (HP:0003700)1.80155359
108Pterygium (HP:0001059)1.79611632
109Abnormality of skeletal muscle fiber size (HP:0012084)1.78460889
110Long toe (HP:0010511)1.77287371
111Ketoacidosis (HP:0001993)1.75773375
112Coxa vara (HP:0002812)1.75536421
113Premature skin wrinkling (HP:0100678)1.75321371
114Breech presentation (HP:0001623)1.74901576
115Tibial bowing (HP:0002982)1.74735380
116Elbow flexion contracture (HP:0002987)1.74551282
117Broad ribs (HP:0000885)1.73642329
118Cerebral inclusion bodies (HP:0100314)1.73314815
119Arterial tortuosity (HP:0005116)1.73054648
120Ovoid vertebral bodies (HP:0003300)1.72783370
121Tarsal synostosis (HP:0008368)1.72336430
122Distal lower limb amyotrophy (HP:0008944)1.72329330
123Camptodactyly of toe (HP:0001836)1.71853049
124Hypoventilation (HP:0002791)1.71232554
125Thin skin (HP:0000963)1.71177334
126Disproportionate tall stature (HP:0001519)1.70651000
127Abnormality of the acetabulum (HP:0003170)1.69508201
128Ulnar deviation of the wrist (HP:0003049)1.68925133
129Achilles tendon contracture (HP:0001771)1.68503370
130Hepatocellular carcinoma (HP:0001402)1.68020226
131Joint laxity (HP:0001388)1.67862878
132Fat malabsorption (HP:0002630)1.67652427
133Round ear (HP:0100830)1.67564082
134Knee flexion contracture (HP:0006380)1.65365890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.12350829
2DDR23.47707053
3SIK13.34264790
4ERN13.10100402
5PDGFRA3.01732657
6LATS12.77049734
7TTN2.58250370
8PKN22.38866062
9EPHB12.35442009
10RIPK12.33090054
11PTK62.27378183
12FGFR22.12494886
13PTK22.11023901
14MET2.05953440
15FGFR42.01092419
16TESK11.99668418
17EPHB21.89814466
18PAK31.89679742
19IRAK31.85455744
20INSRR1.84235395
21EPHA31.71006072
22PIK3CG1.68558419
23LATS21.60469282
24PIM21.59894700
25FER1.56897462
26BCKDK1.53055740
27NTRK11.47087393
28BMX1.47072493
29ERBB41.44896859
30LMTK21.42358808
31ICK1.36782355
32PAK21.35932352
33PAK61.35014536
34RPS6KA21.34265190
35MAP3K61.28213270
36PDGFRB1.26317215
37STK381.19172829
38TIE11.17180905
39FGFR11.16349148
40NME21.10981937
41ARAF1.08666779
42EPHA21.07813993
43CAMK1G1.01238987
44PIK3CA1.00044485
45MAP3K100.96123038
46PRKG20.95711887
47TYRO30.95376871
48RET0.95190818
49MAPK150.93394526
50PAK40.92138743
51MTOR0.91292197
52SMG10.89631986
53MAP2K30.88945841
54ERBB20.88087711
55FLT30.87522413
56PTK2B0.87173584
57PRKD30.86249898
58DAPK30.85497523
59DMPK0.83735307
60ROCK20.83566435
61ROCK10.82029028
62PRKD10.81528000
63PRKCH0.80575171
64DYRK1B0.80454559
65MAPKAPK30.77164824
66MAP3K70.76121579
67KDR0.75515687
68MST1R0.75077275
69CDC42BPA0.74987044
70RPS6KL10.72065340
71RPS6KC10.72065340
72MAP3K20.71558001
73KIT0.71497627
74FRK0.70923943
75MAP2K10.69439666
76CAMK1D0.68325730
77EEF2K0.66936453
78STK390.66787465
79LIMK10.66708727
80CDK120.65808530
81MUSK0.64862811
82WNK10.64418716
83LRRK20.63948803
84PRPF4B0.63661099
85TGFBR20.63305780
86ILK0.61784096
87CSNK1A1L0.60775782
88CAMKK10.59808587
89ADRBK10.59248082
90ABL20.59154598
91TRPM70.57630134
92RPS6KA60.57260630
93PRKD20.55258015
94MOS0.54213313
95GSK3A0.53700167
96MARK20.52759552
97TAOK20.52100564
98TBK10.51839549
99STK30.50719119
100INSR0.50643942
101PDPK10.49098522
102ZAP700.47216523
103AKT30.46607331
104SRC0.45420578
105CDK60.45387239
106CAMK2G0.44954653
107JAK30.44610373
108KSR10.43279959
109DAPK20.42234930
110PKN10.42072249
111PRKAA20.41392442
112CAMK2D0.40851624
113CDK80.40502028
114KSR20.40440174
115WNK40.38753565
116HIPK20.38349289
117PRKCE0.37754556
118JAK10.37185047
119MAP3K30.37068729
120CLK10.36025255
121IGF1R0.36016900
122BCR0.35341940
123NEK90.35250979
124MAP3K130.35100148
125MAP2K20.34748689
126GRK70.34293053
127CSNK1G10.34065322
128MYLK0.34009021
129TGFBR10.33680311
130CDK90.32585273
131TYK20.32423172
132FYN0.30872278
133MAPK40.30768616
134MAP2K40.30648519
135CDK150.30394198
136STK38L0.29929475
137OXSR10.29073331
138MAPKAPK20.29013736
139MAPK70.28955806

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.55190430
2Nitrogen metabolism_Homo sapiens_hsa009103.36722091
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.88686257
4Other glycan degradation_Homo sapiens_hsa005112.65431370
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.51233891
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44291301
7Complement and coagulation cascades_Homo sapiens_hsa046102.43757818
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.36025693
9Arginine biosynthesis_Homo sapiens_hsa002202.24104651
10Tryptophan metabolism_Homo sapiens_hsa003802.20728472
11Fatty acid degradation_Homo sapiens_hsa000712.15522259
12ECM-receptor interaction_Homo sapiens_hsa045122.05808872
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87695316
14Butanoate metabolism_Homo sapiens_hsa006501.84701602
15Fatty acid metabolism_Homo sapiens_hsa012121.75117846
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74271118
17PPAR signaling pathway_Homo sapiens_hsa033201.73660750
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.71053845
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.63153018
20Bile secretion_Homo sapiens_hsa049761.53949262
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.52545366
22Sulfur metabolism_Homo sapiens_hsa009201.51456995
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48696497
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46443982
25Chemical carcinogenesis_Homo sapiens_hsa052041.44662867
26Steroid biosynthesis_Homo sapiens_hsa001001.35529838
27Regulation of actin cytoskeleton_Homo sapiens_hsa048101.34348805
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.34113759
29Peroxisome_Homo sapiens_hsa041461.33964931
30Histidine metabolism_Homo sapiens_hsa003401.33645106
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.32092520
32Notch signaling pathway_Homo sapiens_hsa043301.26013660
33Focal adhesion_Homo sapiens_hsa045101.25688118
34Fatty acid elongation_Homo sapiens_hsa000621.23976191
35Propanoate metabolism_Homo sapiens_hsa006401.21122644
36Chronic myeloid leukemia_Homo sapiens_hsa052201.17981477
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17569264
38Lysosome_Homo sapiens_hsa041421.17506457
39Protein digestion and absorption_Homo sapiens_hsa049741.15694745
40Selenocompound metabolism_Homo sapiens_hsa004501.15388200
41Retinol metabolism_Homo sapiens_hsa008301.09155736
42Galactose metabolism_Homo sapiens_hsa000521.05274731
43Lysine degradation_Homo sapiens_hsa003101.03900205
44Pathways in cancer_Homo sapiens_hsa052001.02644843
45Starch and sucrose metabolism_Homo sapiens_hsa005001.02450072
46beta-Alanine metabolism_Homo sapiens_hsa004101.01219966
47MicroRNAs in cancer_Homo sapiens_hsa052061.00462005
48Amoebiasis_Homo sapiens_hsa051460.99397414
49Phenylalanine metabolism_Homo sapiens_hsa003600.98259457
50Caffeine metabolism_Homo sapiens_hsa002320.98253144
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97858912
52Arginine and proline metabolism_Homo sapiens_hsa003300.94539263
53N-Glycan biosynthesis_Homo sapiens_hsa005100.93955219
54Proteoglycans in cancer_Homo sapiens_hsa052050.93208042
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91720902
56Tyrosine metabolism_Homo sapiens_hsa003500.91657395
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90683607
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88312298
59Staphylococcus aureus infection_Homo sapiens_hsa051500.86957325
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86047200
61ABC transporters_Homo sapiens_hsa020100.85972677
62Fat digestion and absorption_Homo sapiens_hsa049750.85894179
63Melanoma_Homo sapiens_hsa052180.85407316
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84785438
65Sphingolipid metabolism_Homo sapiens_hsa006000.84130152
66TNF signaling pathway_Homo sapiens_hsa046680.83933783
67Bladder cancer_Homo sapiens_hsa052190.83409051
68Pertussis_Homo sapiens_hsa051330.83290250
69Toxoplasmosis_Homo sapiens_hsa051450.83280869
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.82780162
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.77403641
72VEGF signaling pathway_Homo sapiens_hsa043700.77273702
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76655521
74Dilated cardiomyopathy_Homo sapiens_hsa054140.76316841
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75100819
76Basal cell carcinoma_Homo sapiens_hsa052170.74315135
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.74174836
78Pancreatic cancer_Homo sapiens_hsa052120.73869409
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73113281
80Pyruvate metabolism_Homo sapiens_hsa006200.72039943
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.70302502
82Prion diseases_Homo sapiens_hsa050200.69732818
83Shigellosis_Homo sapiens_hsa051310.68831577
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67894835
85Insulin resistance_Homo sapiens_hsa049310.66924804
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66623812
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.65770963
88Hedgehog signaling pathway_Homo sapiens_hsa043400.65719506
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65155192
90Vibrio cholerae infection_Homo sapiens_hsa051100.65144314
91Sulfur relay system_Homo sapiens_hsa041220.64249687
92Endocytosis_Homo sapiens_hsa041440.63655920
93GnRH signaling pathway_Homo sapiens_hsa049120.62559638
94Salmonella infection_Homo sapiens_hsa051320.62425136
95Rap1 signaling pathway_Homo sapiens_hsa040150.61241709
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59991317
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59256235
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.58504134
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58424351
100Gap junction_Homo sapiens_hsa045400.57563622
101Axon guidance_Homo sapiens_hsa043600.56691584
102Hippo signaling pathway_Homo sapiens_hsa043900.56004492
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55867427
104Fructose and mannose metabolism_Homo sapiens_hsa000510.54917034
105Ovarian steroidogenesis_Homo sapiens_hsa049130.54467719
106Fatty acid biosynthesis_Homo sapiens_hsa000610.53599567
107p53 signaling pathway_Homo sapiens_hsa041150.53120555
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53072520
109Adherens junction_Homo sapiens_hsa045200.51881878
110Biosynthesis of amino acids_Homo sapiens_hsa012300.51397546
111Platelet activation_Homo sapiens_hsa046110.51114667
112Carbon metabolism_Homo sapiens_hsa012000.50281393
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.50223217
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50073301
115Pentose phosphate pathway_Homo sapiens_hsa000300.49992235
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49936981
117Renin-angiotensin system_Homo sapiens_hsa046140.49832934
118Acute myeloid leukemia_Homo sapiens_hsa052210.48619308
119Prostate cancer_Homo sapiens_hsa052150.48546704
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48117765
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44012888
122TGF-beta signaling pathway_Homo sapiens_hsa043500.43860937
123ErbB signaling pathway_Homo sapiens_hsa040120.43581592
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.43185044
125Small cell lung cancer_Homo sapiens_hsa052220.42905444
126Thyroid hormone synthesis_Homo sapiens_hsa049180.42869996
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41511518
128Hepatitis C_Homo sapiens_hsa051600.40980057
129Type II diabetes mellitus_Homo sapiens_hsa049300.40257017
130Insulin signaling pathway_Homo sapiens_hsa049100.39846992
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39755780
132mTOR signaling pathway_Homo sapiens_hsa041500.39249652
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39158676
134AMPK signaling pathway_Homo sapiens_hsa041520.39050811
135Vitamin digestion and absorption_Homo sapiens_hsa049770.38445930
136Mineral absorption_Homo sapiens_hsa049780.37366999
137Dorso-ventral axis formation_Homo sapiens_hsa043200.37327506
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37230981
139Thyroid cancer_Homo sapiens_hsa052160.36656317
140Glycerolipid metabolism_Homo sapiens_hsa005610.36339170
141Tight junction_Homo sapiens_hsa045300.36102083
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.35917145
143Folate biosynthesis_Homo sapiens_hsa007900.35111088
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.35009869
145Malaria_Homo sapiens_hsa051440.34315458
146Prolactin signaling pathway_Homo sapiens_hsa049170.34272118
147Ras signaling pathway_Homo sapiens_hsa040140.34265310
148Glutathione metabolism_Homo sapiens_hsa004800.33813506
149Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33495895
150Glucagon signaling pathway_Homo sapiens_hsa049220.32352600
151Glioma_Homo sapiens_hsa052140.31372360
152Melanogenesis_Homo sapiens_hsa049160.30887448
153Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29524716
154Estrogen signaling pathway_Homo sapiens_hsa049150.28041771
155Renal cell carcinoma_Homo sapiens_hsa052110.27667604
156Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25992115

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