BMP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1midgut development (GO:0007494)5.99041070
2regulation of cardioblast differentiation (GO:0051890)5.37754245
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.31777910
4L-phenylalanine catabolic process (GO:0006559)5.31777910
5sequestering of extracellular ligand from receptor (GO:0035581)5.30139137
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.85538314
7L-phenylalanine metabolic process (GO:0006558)4.85538314
8aromatic amino acid family catabolic process (GO:0009074)4.65761097
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.62070868
10lung vasculature development (GO:0060426)4.29513213
11protein carboxylation (GO:0018214)4.28405634
12peptidyl-glutamic acid carboxylation (GO:0017187)4.28405634
13embryonic foregut morphogenesis (GO:0048617)4.27131889
14indole-containing compound catabolic process (GO:0042436)4.22774348
15indolalkylamine catabolic process (GO:0046218)4.22774348
16tryptophan catabolic process (GO:0006569)4.22774348
17bundle of His cell to Purkinje myocyte communication (GO:0086069)4.19020106
18anterior/posterior axis specification, embryo (GO:0008595)4.12864500
19cellular glucuronidation (GO:0052695)4.08341192
20high-density lipoprotein particle remodeling (GO:0034375)4.07884412
21tryptophan metabolic process (GO:0006568)4.07301719
22bile acid biosynthetic process (GO:0006699)4.06078026
23regulation of transforming growth factor beta2 production (GO:0032909)4.02737335
24negative regulation of complement activation (GO:0045916)3.97931922
25bone trabecula formation (GO:0060346)3.94234850
26kynurenine metabolic process (GO:0070189)3.93837042
27regulation of cholesterol esterification (GO:0010872)3.90441556
28glucuronate metabolic process (GO:0019585)3.90326005
29uronic acid metabolic process (GO:0006063)3.90326005
30regulation of fibrinolysis (GO:0051917)3.88081724
31mesodermal cell differentiation (GO:0048333)3.85168951
32regulation of protein activation cascade (GO:2000257)3.84305757
33notochord development (GO:0030903)3.83680153
34alpha-linolenic acid metabolic process (GO:0036109)3.83559797
35cell adhesion mediated by integrin (GO:0033627)3.79453126
36phospholipid efflux (GO:0033700)3.79373899
37primitive streak formation (GO:0090009)3.79219068
38complement activation, alternative pathway (GO:0006957)3.78310480
39negative regulation of activin receptor signaling pathway (GO:0032926)3.73675806
40fatty acid elongation (GO:0030497)3.73084813
41reverse cholesterol transport (GO:0043691)3.71585240
42establishment of apical/basal cell polarity (GO:0035089)3.70532700
43sulfur amino acid catabolic process (GO:0000098)3.68783786
44negative regulation of fibrinolysis (GO:0051918)3.67592142
45fibrinolysis (GO:0042730)3.67261883
46glyoxylate metabolic process (GO:0046487)3.67240060
47regulation of complement activation (GO:0030449)3.64935807
48branching involved in salivary gland morphogenesis (GO:0060445)3.64516120
49regulation of relaxation of muscle (GO:1901077)3.61188471
50bile acid metabolic process (GO:0008206)3.59812783
51endodermal cell differentiation (GO:0035987)3.59595179
52cholesterol efflux (GO:0033344)3.59118525
53regulation of triglyceride catabolic process (GO:0010896)3.57546735
54triglyceride homeostasis (GO:0070328)3.56770088
55acylglycerol homeostasis (GO:0055090)3.56770088
56urea cycle (GO:0000050)3.50238499
57urea metabolic process (GO:0019627)3.50238499
58plasma lipoprotein particle clearance (GO:0034381)3.47992931
59retina vasculature morphogenesis in camera-type eye (GO:0061299)3.47406526
60negative regulation of lipase activity (GO:0060192)3.44186025
61plasma lipoprotein particle assembly (GO:0034377)3.44117423
62negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.42742485
63polarized epithelial cell differentiation (GO:0030859)3.41981677
64dorsal/ventral axis specification (GO:0009950)3.38183398
65plasma lipoprotein particle remodeling (GO:0034369)3.37588526
66protein-lipid complex remodeling (GO:0034368)3.37588526
67macromolecular complex remodeling (GO:0034367)3.37588526
68negative regulation of sterol transport (GO:0032372)3.34372286
69negative regulation of cholesterol transport (GO:0032375)3.34372286
70hepatocyte differentiation (GO:0070365)3.33291850
71very-low-density lipoprotein particle assembly (GO:0034379)3.32578280
72cellular response to sterol (GO:0036315)3.31282661
73regulation of cardiac muscle cell contraction (GO:0086004)3.28695639
74regulation of cholesterol homeostasis (GO:2000188)3.28308487
75bile acid and bile salt transport (GO:0015721)3.27815988
76hemidesmosome assembly (GO:0031581)3.25830701
77tyrosine metabolic process (GO:0006570)3.25574124
78nodal signaling pathway (GO:0038092)3.24467232
79chondrocyte development (GO:0002063)3.21916762
80chondrocyte proliferation (GO:0035988)3.20946998
81aromatic amino acid family metabolic process (GO:0009072)3.20920325
82protein-lipid complex assembly (GO:0065005)3.20287924
83cysteine metabolic process (GO:0006534)3.18634008
84very long-chain fatty acid metabolic process (GO:0000038)3.18134588
85epithelial tube branching involved in lung morphogenesis (GO:0060441)3.15964286
86gap junction assembly (GO:0016264)3.15218420
87nitrogen cycle metabolic process (GO:0071941)3.14710647
88fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.14592664
89positive regulation of cardiac muscle cell proliferation (GO:0060045)3.14540323
90paraxial mesoderm development (GO:0048339)3.13275277
91cellular biogenic amine catabolic process (GO:0042402)3.12971079
92amine catabolic process (GO:0009310)3.12971079
93morphogenesis of an epithelial sheet (GO:0002011)3.11269036
94establishment of monopolar cell polarity (GO:0061162)3.08995546
95establishment or maintenance of monopolar cell polarity (GO:0061339)3.08995546
96endocardial cushion development (GO:0003197)3.07864760
97amino-acid betaine metabolic process (GO:0006577)3.07244384
98cholesterol homeostasis (GO:0042632)3.06327618
99regulation of transforming growth factor beta1 production (GO:0032908)3.05931633
100* atrioventricular valve morphogenesis (GO:0003181)3.05313570
101regulation of bile acid biosynthetic process (GO:0070857)3.02199507
102indolalkylamine metabolic process (GO:0006586)3.01827504
103cell migration involved in gastrulation (GO:0042074)3.01292093
104sterol homeostasis (GO:0055092)3.00936680
105desmosome organization (GO:0002934)3.00041135
106ethanol oxidation (GO:0006069)2.99805028
107opsonization (GO:0008228)2.99646776
108positive regulation of fatty acid beta-oxidation (GO:0032000)2.98951680
109positive regulation of lipid catabolic process (GO:0050996)2.98081714
110neural crest cell development (GO:0014032)2.93748092
111lipoprotein metabolic process (GO:0042157)2.92167875
112regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.91101320
113positive regulation of cardiac muscle tissue development (GO:0055025)2.90647369
114regulation of phospholipase A2 activity (GO:0032429)2.90206873
115benzene-containing compound metabolic process (GO:0042537)2.89606959
116intestinal cholesterol absorption (GO:0030299)2.89440692
117iron ion import (GO:0097286)2.89213257
118outflow tract septum morphogenesis (GO:0003148)2.88229361
119negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.88133080
120regulation of activin receptor signaling pathway (GO:0032925)2.86655173
121* regulation of glucocorticoid metabolic process (GO:0031943)2.86231323
122lung lobe morphogenesis (GO:0060463)2.85334097
123low-density lipoprotein particle remodeling (GO:0034374)2.84682350
124cell migration involved in sprouting angiogenesis (GO:0002042)2.84480015
125complement activation (GO:0006956)2.83418507
126renal absorption (GO:0070293)2.82574582
127* regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.82013594
128cellular response to cholesterol (GO:0071397)2.81805373
129epithelial cell-cell adhesion (GO:0090136)2.81588648
130coenzyme catabolic process (GO:0009109)2.80912367
131positive regulation of triglyceride lipase activity (GO:0061365)2.80696773
132positive regulation of lipoprotein lipase activity (GO:0051006)2.80696773
133negative regulation of hemostasis (GO:1900047)2.80388869
134negative regulation of blood coagulation (GO:0030195)2.80388869
135endoderm formation (GO:0001706)2.80086626
136positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.79888746
137* negative regulation of hormone biosynthetic process (GO:0032353)2.79832074
138plasma lipoprotein particle organization (GO:0071827)2.79583590
139homocysteine metabolic process (GO:0050667)2.77757776
140alpha-amino acid catabolic process (GO:1901606)2.76886048
141protein activation cascade (GO:0072376)2.76811378
142regulation of plasminogen activation (GO:0010755)2.76795661
143extracellular negative regulation of signal transduction (GO:1900116)2.76156066
144extracellular regulation of signal transduction (GO:1900115)2.76156066
145drug catabolic process (GO:0042737)2.74263655
146cofactor catabolic process (GO:0051187)2.73887845
147uterus development (GO:0060065)2.73488277
148negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.72350415
149surfactant homeostasis (GO:0043129)2.71864378
150negative regulation of protein activation cascade (GO:2000258)2.71605411
151epoxygenase P450 pathway (GO:0019373)2.71018783
152negative regulation of wound healing (GO:0061045)2.70814095
153limb bud formation (GO:0060174)2.70755985
154positive regulation of steroid metabolic process (GO:0045940)2.70432626
155cholesterol biosynthetic process (GO:0006695)2.70316530
156mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.70026779
157protein-lipid complex subunit organization (GO:0071825)2.69910580
158cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.69892203
159complement activation, classical pathway (GO:0006958)2.69824336
160embryonic axis specification (GO:0000578)2.69660049
161aldehyde catabolic process (GO:0046185)2.68618415
162positive regulation of cardiac muscle tissue growth (GO:0055023)2.67925469
163negative regulation of chondrocyte differentiation (GO:0032331)2.67813198
164negative regulation of keratinocyte proliferation (GO:0010839)2.64846370
165wound healing, spreading of epidermal cells (GO:0035313)2.64756789
166* negative regulation of hormone metabolic process (GO:0032351)2.64699237
167negative regulation of humoral immune response (GO:0002921)2.63916930
168basement membrane organization (GO:0071711)2.62546650
169negative regulation of axon extension involved in axon guidance (GO:0048843)2.62220491
170ureteric bud development (GO:0001657)2.61783027
171genitalia morphogenesis (GO:0035112)2.60707372
172endothelial cell morphogenesis (GO:0001886)2.60550690
173* positive regulation of osteoblast proliferation (GO:0033690)2.60221597
174embryonic process involved in female pregnancy (GO:0060136)2.60178686
175cellular response to fluid shear stress (GO:0071498)2.59397157
176response to laminar fluid shear stress (GO:0034616)2.59325796
177positive regulation of catenin import into nucleus (GO:0035413)2.59121507
178* regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)2.58087387
179* cardiocyte differentiation (GO:0035051)2.57548454
180thyroid hormone generation (GO:0006590)2.57002580
181anterior/posterior axis specification (GO:0009948)2.56980159
182regulation of tight junction assembly (GO:2000810)2.54113821
183positive regulation of urine volume (GO:0035810)2.53939596
184mesenchymal-epithelial cell signaling (GO:0060638)2.53708380
185regulation of cardiac muscle cell proliferation (GO:0060043)2.53078837
186trophoblast giant cell differentiation (GO:0060707)2.51027710
187* cardiac muscle cell differentiation (GO:0055007)2.50978035
188regulation of actin filament-based movement (GO:1903115)2.50874841
189cardiac septum morphogenesis (GO:0060411)2.48064020
190Rap protein signal transduction (GO:0032486)2.47712378
191skin morphogenesis (GO:0043589)2.46148930
192regulation of mesoderm development (GO:2000380)2.45452308
193chemical homeostasis within a tissue (GO:0048875)2.45442038
194embryonic retina morphogenesis in camera-type eye (GO:0060059)2.44879305

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.45685375
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.70623009
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.22791699
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.61303330
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.47010510
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.41275503
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.36216613
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.15070306
9ZNF263_19887448_ChIP-Seq_K562_Human2.82940867
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.44867212
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.34434919
12* SMAD3_21741376_ChIP-Seq_HESCs_Human2.29437610
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.28281351
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25074617
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19251031
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.05029947
17AR_21909140_ChIP-Seq_LNCAP_Human2.01542891
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.91349381
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88292191
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87960320
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.84337741
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.78578459
23AR_21572438_ChIP-Seq_LNCaP_Human1.78542014
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71706019
25* ISL1_27105846_Chip-Seq_CPCs_Mouse1.70267626
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.66968290
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.60194483
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60194198
29* SMAD4_21741376_ChIP-Seq_HESCs_Human1.59374713
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57269128
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.54970501
32CLOCK_20551151_ChIP-Seq_293T_Human1.54965020
33SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.54773369
34BRD4_25478319_ChIP-Seq_HGPS_Human1.49363622
35CJUN_26792858_Chip-Seq_BT549_Human1.47718900
36* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46901607
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44939890
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44784341
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43735247
40* SOX2_20726797_ChIP-Seq_SW620_Human1.42604496
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42192721
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40434209
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.39441151
44UBF1/2_26484160_Chip-Seq_HMECs_Human1.38444393
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38143637
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38143637
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.36614030
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36408161
49TCF4_18268006_ChIP-ChIP_LS174T_Human1.30299356
50EOMES_21245162_ChIP-Seq_HESCs_Human1.30150668
51EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.28492572
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27138652
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25294373
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24821700
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24440403
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.24165848
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23903259
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22490794
59* TP53_18474530_ChIP-ChIP_U2OS_Human1.22090380
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.20701265
61* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20407224
62* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19928348
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19646800
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19129979
65FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18420361
66EGR1_19032775_ChIP-ChIP_M12_Human1.16762159
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16410863
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15874094
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15465310
70TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14962825
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.14738931
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14385878
73STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13748408
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11801762
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11702317
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11186931
77* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10765595
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09971673
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09524607
80* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09479684
81* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08905415
82FOXA2_19822575_ChIP-Seq_HepG2_Human1.08662718
83* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08198516
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07839959
85* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07798018
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06514908
87CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05652974
88* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05559214
89TBX20_22328084_ChIP-Seq_HEART_Mouse1.04678928
90TBX20_22080862_ChIP-Seq_HEART_Mouse1.04678928
91* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02851957
92* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01912901
93* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01912901
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01842029
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01318976
96HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99952067
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.99902151
98TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99720769
99TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99685421
100CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99573172
101TP63_23658742_ChIP-Seq_EP156T_Human0.99432307
102NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99161710
103NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98996249
104VDR_24787735_ChIP-Seq_THP-1_Human0.97343373
105AHR_22903824_ChIP-Seq_MCF-7_Human0.96422533
106GATA4_25053715_ChIP-Seq_YYC3_Human0.96130326
107EZH2_27304074_Chip-Seq_ESCs_Mouse0.96032949
108* RING1B_27294783_Chip-Seq_NPCs_Mouse0.95865626
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95569589
110WT1_19549856_ChIP-ChIP_CCG9911_Human0.95357659
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.94262513
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93425670
113* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92953420
114* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91174528
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91005248
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90424892
117* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89884978
118SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89149640
119SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89149640
120TP53_16413492_ChIP-PET_HCT116_Human0.88602707
121JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87302360
122HTT_18923047_ChIP-ChIP_STHdh_Human0.86694382
123ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85767509
124FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84249587
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83355555
126ERG_21242973_ChIP-ChIP_JURKAT_Human0.82981108
127* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.82674129
128KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82010011
129KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82010011
130KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82010011
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.81288893
132TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.80414509
133EZH2_27294783_Chip-Seq_ESCs_Mouse0.80186593
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.79845126
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79696003
136BCAT_22108803_ChIP-Seq_LS180_Human0.79523032
137* SMAD3_21741376_ChIP-Seq_EPCs_Human0.78646639
138BP1_19119308_ChIP-ChIP_Hs578T_Human0.78271255
139JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77662884
140RXR_22108803_ChIP-Seq_LS180_Human0.77337799
141SUZ12_27294783_Chip-Seq_ESCs_Mouse0.76669744
142AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.75815141
143* TP53_20018659_ChIP-ChIP_R1E_Mouse0.75611190
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74821327

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.50535859
2MP0005360_urolithiasis4.96269205
3MP0005085_abnormal_gallbladder_physiolo4.43181083
4MP0005365_abnormal_bile_salt3.71096509
5MP0003890_abnormal_embryonic-extraembry3.69862866
6MP0010234_abnormal_vibrissa_follicle3.61543452
7MP0008875_abnormal_xenobiotic_pharmacok3.48259558
8MP0005275_abnormal_skin_tensile3.03412903
9MP0009840_abnormal_foam_cell2.78287052
10MP0000462_abnormal_digestive_system2.69408807
11MP0003566_abnormal_cell_adhesion2.64541253
12MP0002254_reproductive_system_inflammat2.60336341
13MP0003283_abnormal_digestive_organ2.59912570
14MP0003252_abnormal_bile_duct2.51795839
15MP0010329_abnormal_lipoprotein_level2.33781762
16MP0001666_abnormal_nutrient_absorption2.32751480
17MP0002796_impaired_skin_barrier2.23277739
18MP0005083_abnormal_biliary_tract2.16438792
19MP0002098_abnormal_vibrissa_morphology2.13500197
20MP0000537_abnormal_urethra_morphology2.11619132
21MP0003806_abnormal_nucleotide_metabolis2.10648695
22MP0004134_abnormal_chest_morphology2.10555282
23MP0003950_abnormal_plasma_membrane2.03067588
24MP0004084_abnormal_cardiac_muscle1.97317758
25MP0008775_abnormal_heart_ventricle1.96617338
26MP0003195_calcinosis1.92925874
27MP0003119_abnormal_digestive_system1.91312459
28MP0009384_cardiac_valve_regurgitation1.86326316
29MP0000579_abnormal_nail_morphology1.85968047
30MP0002282_abnormal_trachea_morphology1.83026052
31MP0010678_abnormal_skin_adnexa1.82364476
32MP0004272_abnormal_basement_membrane1.80468062
33MP0010368_abnormal_lymphatic_system1.79695278
34MP0005451_abnormal_body_composition1.76805281
35* MP0003937_abnormal_limbs/digits/tail_de1.75544317
36MP0008438_abnormal_cutaneous_collagen1.75108225
37MP0004019_abnormal_vitamin_homeostasis1.73967039
38MP0010352_gastrointestinal_tract_polyps1.65473856
39MP0003705_abnormal_hypodermis_morpholog1.61869706
40MP0000762_abnormal_tongue_morphology1.57709206
41MP0004381_abnormal_hair_follicle1.57585957
42MP0004510_myositis1.55844027
43MP0002138_abnormal_hepatobiliary_system1.53856838
44MP0004133_heterotaxia1.53096720
45MP0002697_abnormal_eye_size1.52897316
46MP0002060_abnormal_skin_morphology1.52423013
47MP0003091_abnormal_cell_migration1.52347603
48MP0004145_abnormal_muscle_electrophysio1.48808284
49MP0005503_abnormal_tendon_morphology1.47403246
50MP0005257_abnormal_intraocular_pressure1.47153743
51MP0005332_abnormal_amino_acid1.42397724
52MP0000647_abnormal_sebaceous_gland1.40485172
53MP0004215_abnormal_myocardial_fiber1.40306004
54MP0009697_abnormal_copulation1.38443150
55MP0004264_abnormal_extraembryonic_tissu1.38159848
56MP0006054_spinal_hemorrhage1.38095616
57* MP0000163_abnormal_cartilage_morphology1.37752754
58MP0002118_abnormal_lipid_homeostasis1.37476600
59MP0002233_abnormal_nose_morphology1.37015692
60MP0009780_abnormal_chondrocyte_physiolo1.36276615
61* MP0009250_abnormal_appendicular_skeleto1.33068178
62MP0002933_joint_inflammation1.31809496
63MP0005197_abnormal_uvea_morphology1.29547227
64MP0003191_abnormal_cellular_cholesterol1.28708578
65MP0000013_abnormal_adipose_tissue1.25659455
66* MP0003984_embryonic_growth_retardation1.25423493
67MP0001661_extended_life_span1.23353646
68MP0009053_abnormal_anal_canal1.23284452
69MP0005330_cardiomyopathy1.23042193
70* MP0002088_abnormal_embryonic_growth/wei1.22694188
71* MP0002084_abnormal_developmental_patter1.22559578
72MP0000751_myopathy1.21937349
73MP0000609_abnormal_liver_physiology1.21682820
74MP0005187_abnormal_penis_morphology1.20108051
75MP0005076_abnormal_cell_differentiation1.17815850
76MP0003868_abnormal_feces_composition1.15727577
77MP0000428_abnormal_craniofacial_morphol1.14879067
78MP0002127_abnormal_cardiovascular_syste1.14796261
79* MP0005380_embryogenesis_phenotype1.13607151
80* MP0001672_abnormal_embryogenesis/_devel1.13607151
81MP0002972_abnormal_cardiac_muscle1.13160452
82MP0004085_abnormal_heartbeat1.11960872
83* MP0002925_abnormal_cardiovascular_devel1.11868197
84* MP0003935_abnormal_craniofacial_develop1.11682896
85MP0000377_abnormal_hair_follicle1.11241406
86MP0000383_abnormal_hair_follicle1.10874061
87MP0002089_abnormal_postnatal_growth/wei1.10794768
88MP0002249_abnormal_larynx_morphology1.10423006
89MP0009379_abnormal_foot_pigmentation1.10400732
90* MP0002111_abnormal_tail_morphology1.09749051
91MP0006138_congestive_heart_failure1.08549273
92* MP0002115_abnormal_skeleton_extremities1.07652781
93* MP0002086_abnormal_extraembryonic_tissu1.07648845
94MP0002896_abnormal_bone_mineralization1.07592646
95MP0003115_abnormal_respiratory_system1.06371855
96MP0001346_abnormal_lacrimal_gland1.05538193
97MP0001216_abnormal_epidermal_layer1.02182892
98MP0005508_abnormal_skeleton_morphology1.01665433
99MP0005220_abnormal_exocrine_pancreas1.00862355
100MP0010630_abnormal_cardiac_muscle1.00601387
101MP0003011_delayed_dark_adaptation0.99732415
102* MP0001614_abnormal_blood_vessel0.98728767
103MP0005248_abnormal_Harderian_gland0.98175848
104MP0000432_abnormal_head_morphology0.97615860
105MP0003690_abnormal_glial_cell0.96567939
106MP0005501_abnormal_skin_physiology0.96489446
107MP0000534_abnormal_ureter_morphology0.96006044
108MP0000003_abnormal_adipose_tissue0.95724852
109MP0005164_abnormal_response_to0.93658106
110MP0005623_abnormal_meninges_morphology0.91716788
111MP0003942_abnormal_urinary_system0.91154613
112MP0005023_abnormal_wound_healing0.91149868
113MP0004043_abnormal_pH_regulation0.90987345
114MP0005409_darkened_coat_color0.90824498
115MP0001243_abnormal_dermal_layer0.90533498
116MP0000733_abnormal_muscle_development0.88082415
117MP0003453_abnormal_keratinocyte_physiol0.86705436
118MP0010771_integument_phenotype0.86362163
119MP0005367_renal/urinary_system_phenotyp0.84549060
120MP0000516_abnormal_urinary_system0.84549060
121MP0005584_abnormal_enzyme/coenzyme_acti0.83949057
122MP0008004_abnormal_stomach_pH0.83786019
123MP0005167_abnormal_blood-brain_barrier0.83617256
124MP0005390_skeleton_phenotype0.83387802
125MP0000467_abnormal_esophagus_morphology0.83153942
126MP0001299_abnormal_eye_distance/0.81548491
127MP0005319_abnormal_enzyme/_coenzyme0.81405831
128MP0009672_abnormal_birth_weight0.81371983
129* MP0002932_abnormal_joint_morphology0.81217423
130MP0000427_abnormal_hair_cycle0.81130239
131MP0001533_abnormal_skeleton_physiology0.80784423
132MP0001340_abnormal_eyelid_morphology0.80012828
133MP0000343_altered_response_to0.79232937
134MP0010030_abnormal_orbit_morphology0.77981966
135MP0001542_abnormal_bone_strength0.77861296
136MP0001177_atelectasis0.77218856
137MP0009703_decreased_birth_body0.76728244
138MP0001915_intracranial_hemorrhage0.76539352
139MP0009643_abnormal_urine_homeostasis0.76078274
140MP0003279_aneurysm0.75469072
141MP0000750_abnormal_muscle_regeneration0.75225218
142MP0005595_abnormal_vascular_smooth0.75086666
143MP0001851_eye_inflammation0.74536608
144* MP0002085_abnormal_embryonic_tissue0.74214010
145* MP0003385_abnormal_body_wall0.74135695
146MP0003638_abnormal_response/metabolism_0.74052220
147MP0000604_amyloidosis0.72884113
148MP0009764_decreased_sensitivity_to0.72536955
149MP0002295_abnormal_pulmonary_circulatio0.72013658
150MP0000920_abnormal_myelination0.71458945
151MP0000639_abnormal_adrenal_gland0.69638958
152MP0003755_abnormal_palate_morphology0.68972288
153MP0004883_abnormal_blood_vessel0.67709105
154MP0003436_decreased_susceptibility_to0.67621534
155MP0005408_hypopigmentation0.67060295
156MP0001879_abnormal_lymphatic_vessel0.66857249
157* MP0002113_abnormal_skeleton_development0.63666649
158MP0003941_abnormal_skin_development0.63628187
159* MP0002109_abnormal_limb_morphology0.63355558
160MP0009763_increased_sensitivity_to0.62684363
161MP0003186_abnormal_redox_activity0.62518808
162MP0003724_increased_susceptibility_to0.58536681
163MP0004782_abnormal_surfactant_physiolog0.57263429
164MP0000767_abnormal_smooth_muscle0.56189346

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)5.56546800
2Intrahepatic cholestasis (HP:0001406)4.90092964
3Vitreoretinal degeneration (HP:0000655)4.75230957
4Deep venous thrombosis (HP:0002625)4.67475328
5Xanthomatosis (HP:0000991)4.63643438
6Abnormal tarsal ossification (HP:0008369)4.27695883
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.21448665
8Prolonged partial thromboplastin time (HP:0003645)4.18646620
9Irregular epiphyses (HP:0010582)4.16296213
10Complement deficiency (HP:0004431)4.10533777
11Abnormality of monocarboxylic acid metabolism (HP:0010996)4.01696573
12Hypobetalipoproteinemia (HP:0003563)3.88122962
13Abnormal pancreas size (HP:0012094)3.80072523
14Cupped ribs (HP:0000887)3.78739257
15Abnormality of the fetal cardiovascular system (HP:0010948)3.73521419
16Abnormal umbilical cord blood vessels (HP:0011403)3.73521419
17Single umbilical artery (HP:0001195)3.73521419
18Ankyloglossia (HP:0010296)3.57662915
19Abnormality of the nasal septum (HP:0000419)3.51865099
20Flat acetabular roof (HP:0003180)3.37616033
21Abnormality of complement system (HP:0005339)3.36019496
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.28450265
23Arterial tortuosity (HP:0005116)3.25204304
24Hypolipoproteinemia (HP:0010981)3.23034860
25Hypoplastic ischia (HP:0003175)3.17292863
26Hyperlipoproteinemia (HP:0010980)3.16270713
27Hypoalphalipoproteinemia (HP:0003233)3.11679698
28Elbow flexion contracture (HP:0002987)3.10496280
29Epidermoid cyst (HP:0200040)3.01286885
30Abnormal foot bone ossification (HP:0010675)2.97199468
31Abnormality of the common coagulation pathway (HP:0010990)2.95893988
32Abnormality of the ischium (HP:0003174)2.95837714
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.93461418
34Vascular tortuosity (HP:0004948)2.90347405
35Vascular calcification (HP:0004934)2.81769933
36Joint hemorrhage (HP:0005261)2.81587919
37Knee flexion contracture (HP:0006380)2.80339593
38Double outlet right ventricle (HP:0001719)2.80292738
39Congenital malformation of the right heart (HP:0011723)2.80292738
40Right ventricular cardiomyopathy (HP:0011663)2.75929146
41Delayed epiphyseal ossification (HP:0002663)2.75552199
42Fat malabsorption (HP:0002630)2.75181476
43Systemic lupus erythematosus (HP:0002725)2.71808083
44Neonatal short-limb short stature (HP:0008921)2.70372556
45Small epiphyses (HP:0010585)2.69778404
46Abnormality of the umbilical cord (HP:0010881)2.69589069
47Mitral valve prolapse (HP:0001634)2.65371788
48Arthropathy (HP:0003040)2.65337309
49Cardiovascular calcification (HP:0011915)2.63167074
50Myocardial infarction (HP:0001658)2.60854516
51Hydroxyprolinuria (HP:0003080)2.60391723
52Abnormality of proline metabolism (HP:0010907)2.60391723
53Genu varum (HP:0002970)2.60030790
54Overgrowth (HP:0001548)2.59916096
55Glomerulonephritis (HP:0000099)2.59866809
56Abnormality of oral frenula (HP:0000190)2.56144464
57Periauricular skin pits (HP:0100277)2.55443132
58Preauricular pit (HP:0004467)2.55443132
59Flat capital femoral epiphysis (HP:0003370)2.52524927
60Parakeratosis (HP:0001036)2.51988256
61Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.51793336
62Abnormality of carpal bone ossification (HP:0006257)2.51289685
63Protuberant abdomen (HP:0001538)2.50465660
64Neurofibrillary tangles (HP:0002185)2.50227279
65Follicular hyperkeratosis (HP:0007502)2.48410140
66Ventricular tachycardia (HP:0004756)2.46134998
67Metaphyseal dysplasia (HP:0100255)2.43869204
68Osteoarthritis (HP:0002758)2.40676332
69Protrusio acetabuli (HP:0003179)2.38695761
70Abnormal vertebral ossification (HP:0100569)2.37560376
71Myelomeningocele (HP:0002475)2.36932889
72Aortic dissection (HP:0002647)2.33627967
73Abnormality of incisor morphology (HP:0011063)2.29815181
74Abnormality of the intrinsic pathway (HP:0010989)2.29335351
75Onycholysis (HP:0001806)2.29093275
76Abnormality of methionine metabolism (HP:0010901)2.24832654
77Short middle phalanx of the 5th finger (HP:0004220)2.24256751
78Metaphyseal irregularity (HP:0003025)2.23899171
79Increased IgE level (HP:0003212)2.23750233
80Hypoplastic labia majora (HP:0000059)2.23470052
81Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20195577
82Limited hip movement (HP:0008800)2.19099447
83Hypercholesterolemia (HP:0003124)2.18473383
84Metaphyseal cupping (HP:0003021)2.18264723
85Abnormality of the vertebral endplates (HP:0005106)2.17230373
86Arnold-Chiari malformation (HP:0002308)2.16220117
87Abnormality of the lumbar spine (HP:0100712)2.14944545
88Skin pits (HP:0100276)2.13635303
89Hypophosphatemic rickets (HP:0004912)2.13557260
90Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.12065505
91Amyloidosis (HP:0011034)2.10995397
92Conjugated hyperbilirubinemia (HP:0002908)2.10552669
93Bell-shaped thorax (HP:0001591)2.09794177
94Abnormality of sulfur amino acid metabolism (HP:0004339)2.08732158
95Retinal atrophy (HP:0001105)2.08592698
96Hyperammonemia (HP:0001987)2.08377091
97Axonal loss (HP:0003447)2.07504669
98Bifid tongue (HP:0010297)2.06926920
99Steatorrhea (HP:0002570)2.05845905
100Abnormality of the calf musculature (HP:0001430)2.05702419
101Anal stenosis (HP:0002025)2.04302819
102Fragile skin (HP:0001030)2.03391273
103Abnormality of pyrimidine metabolism (HP:0004353)2.02095614
104Achilles tendon contracture (HP:0001771)2.01983884
105Vertebral clefting (HP:0008428)2.01746590
106Abnormality of the labia majora (HP:0012881)2.01132350
107Abnormal hand bone ossification (HP:0010660)2.00753461
108Fragile nails (HP:0001808)2.00626593
109Abnormalities of placenta or umbilical cord (HP:0001194)2.00139395
110Abnormality of the Achilles tendon (HP:0005109)2.00044929
111Shawl scrotum (HP:0000049)1.99679059
112Aplasia involving bones of the extremities (HP:0009825)1.99223997
113Aplasia involving bones of the upper limbs (HP:0009823)1.99223997
114Aplasia of the phalanges of the hand (HP:0009802)1.99223997
115Coxa vara (HP:0002812)1.98726638
116Abnormal ossification of hand bones (HP:0005921)1.98422003
117Abnormality of the distal phalanges of the toes (HP:0010182)1.97815752
118Malnutrition (HP:0004395)1.96586954
119Hepatocellular carcinoma (HP:0001402)1.96376055
120Short humerus (HP:0005792)1.96304513
121Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.95568857
122Abnormality of femoral epiphyses (HP:0006499)1.95568857
123Enlarged epiphyses (HP:0010580)1.94018009
124Premature rupture of membranes (HP:0001788)1.93502359
125Abnormality of the vitreous humor (HP:0004327)1.92376664
126Natal tooth (HP:0000695)1.90510840
127Coronal craniosynostosis (HP:0004440)1.90075056
128Skin nodule (HP:0200036)1.89060581
129Missing ribs (HP:0000921)1.89022374
130Enlarged kidneys (HP:0000105)1.88142535
131Disproportionate tall stature (HP:0001519)1.87459304
132Ulnar bowing (HP:0003031)1.87351376
133Congenital ichthyosiform erythroderma (HP:0007431)1.87078180
134Partial duplication of thumb phalanx (HP:0009944)1.86447683
135Intestinal atresia (HP:0011100)1.85906991
136Aplasia cutis congenita (HP:0001057)1.83615477
137Atrophic scars (HP:0001075)1.83299598
138Bronchomalacia (HP:0002780)1.83276663
139Patent foramen ovale (HP:0001655)1.83121038
140Ectopic anus (HP:0004397)1.81086862
141Labial hypoplasia (HP:0000066)1.80821222
142Thoracolumbar scoliosis (HP:0002944)1.80783119
143Mild short stature (HP:0003502)1.80700516
144Cervical subluxation (HP:0003308)1.79615825
145Transposition of the great arteries (HP:0001669)1.79312700
146Abnormal connection of the cardiac segments (HP:0011545)1.79312700
147Abnormal ventriculo-arterial connection (HP:0011563)1.79312700
148Concave nail (HP:0001598)1.79124329
149Wormian bones (HP:0002645)1.78952116
150Ovoid vertebral bodies (HP:0003300)1.77973468
151Beaking of vertebral bodies (HP:0004568)1.77727104
152Thick nail (HP:0001805)1.77672547
153Mixed hearing impairment (HP:0000410)1.76899497
154Ketosis (HP:0001946)1.76715530
155Deviation of the thumb (HP:0009603)1.76454241
156Pulmonic stenosis (HP:0001642)1.76331725
157Cerebral inclusion bodies (HP:0100314)1.76244326
158Bicuspid aortic valve (HP:0001647)1.76193444
159Nephritis (HP:0000123)1.75159202
160Abnormality of the right ventricle (HP:0001707)1.74791562
161Hepatoblastoma (HP:0002884)1.74746028
162Advanced eruption of teeth (HP:0006288)1.74550297
163Hip contracture (HP:0003273)1.74473415
164Aplasia/hypoplasia of the humerus (HP:0006507)1.74285186
165Flattened epiphyses (HP:0003071)1.74025940
166Pterygium (HP:0001059)1.73477046
167* Abnormality of the phalanges of the 2nd finger (HP:0009541)1.73076778
168Hypotrichosis (HP:0001006)1.70870031
169Irregular vertebral endplates (HP:0003301)1.70742018
170Spontaneous abortion (HP:0005268)1.70362638
171Erythroderma (HP:0001019)1.70214248
172Wide anterior fontanel (HP:0000260)1.69045101
173Vertebral compression fractures (HP:0002953)1.68594546
174Alkalosis (HP:0001948)1.67316297
175Hoarse voice (HP:0001609)1.66015121
176Soft skin (HP:0000977)1.65513193
177Midface retrusion (HP:0011800)1.64153071
178Partial duplication of the phalanx of hand (HP:0009999)1.63270127
179Sparse lateral eyebrow (HP:0005338)1.62636350
180Hypoplastic female external genitalia (HP:0012815)1.62022024
181Ankle contracture (HP:0006466)1.61979701

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK27.43143184
2MAP3K34.41419632
3LMTK23.29228822
4PKN23.24334221
5FLT33.07160358
6AKT32.91058980
7ACVR1B2.73756584
8MST1R2.70252677
9SIK12.55842039
10LATS12.50987823
11DMPK2.48934059
12MST42.36559602
13EPHB12.31330830
14DDR22.24921448
15OBSCN2.21394260
16EPHB22.19717720
17ERN12.17747151
18STK242.04854005
19ERBB42.02966748
20MET2.02466447
21TGFBR21.91861730
22STK38L1.87823047
23PDGFRA1.80325505
24BCR1.77769080
25MAP3K101.75490417
26FGFR41.73804136
27FRK1.73578453
28STK391.59266429
29MAP3K141.58806430
30NUAK11.52460291
31PBK1.50264043
32EPHA21.48234884
33MAPK151.47486526
34BMPR1B1.41746935
35STK31.34687059
36STK101.32336811
37PKN11.32144795
38PRKG21.28113486
39TIE11.27528468
40PAK41.24892042
41BMPR21.22373559
42MAP3K21.21938530
43MAPKAPK51.21388820
44GSK3A1.21053373
45BRSK21.20637175
46NEK61.20333848
47FGFR11.18631615
48PTK61.18203573
49FGFR21.15685103
50KDR1.15513822
51FER1.07911277
52MAP2K21.06246818
53MAPK71.03653849
54GRK11.03632371
55MAPK41.03226911
56MOS0.97625692
57BCKDK0.97418929
58TNIK0.97408257
59MAPK120.96005701
60PIK3CG0.92814779
61OXSR10.92401410
62PTK20.91139902
63INSRR0.90105491
64GRK70.89216666
65MKNK20.89001392
66ICK0.88765398
67PIK3CA0.86987762
68TAOK30.86584320
69NEK90.86319976
70MAP3K90.85847404
71CASK0.85432593
72CSNK1A1L0.84058269
73PLK40.83988545
74PIM20.83920945
75MELK0.83261242
76MYLK0.82907449
77WEE10.80015092
78MAP3K120.77987450
79BRD40.76053668
80CDK60.75692158
81IKBKB0.73463780
82MKNK10.72909685
83TRPM70.71304694
84EPHA30.71195157
85NME10.70202737
86RIPK10.68048775
87MAP2K10.67851997
88ERBB20.67211317
89ABL20.66439256
90ERBB30.65200016
91TGFBR10.65079393
92CSK0.65050773
93PRKCQ0.63856909
94PNCK0.62655311
95STK380.60678128
96CSNK1G10.59516486
97LRRK20.59466010
98MTOR0.58754587
99EPHA40.58103857
100LIMK10.57789260
101MAP3K110.57532965
102PRKAA20.57215603
103ROCK10.56994283
104PAK20.55655156
105PRKD10.55619543
106EIF2AK20.55555868
107RAF10.55548895
108TTK0.53729335
109TAOK20.52946514
110CAMK2G0.51787267
111ADRBK10.51010143
112DYRK1B0.50968899
113ROCK20.50106173
114IGF1R0.49894745
115PDGFRB0.49389357
116NEK10.48122674
117PTK2B0.47027127
118BRAF0.46951884
119CSNK1G30.46470907
120NTRK10.46448440
121MAP3K70.46170628
122TBK10.45198643
123DYRK1A0.43809231
124TYK20.43332360
125BLK0.42878089
126ARAF0.42174815
127PAK30.42132985
128CAMK2D0.42072689
129WNK40.42019733
130MAP2K60.41923633
131EGFR0.41744773
132MAPK110.41599798
133LATS20.41176555
134PRKG10.40831903
135PRKCE0.40335823
136CDK120.39120960
137NEK20.28322060
138RPS6KA20.26816242
139EIF2AK30.26814111
140AKT20.25969953
141RET0.24528897
142PDPK10.22049122
143NLK0.20428232
144TSSK60.20011684
145IRAK30.19939097
146MAPK100.18804051
147MAPK10.17781427
148BMX0.16645285
149MAP3K80.14450059

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.79929177
2Nitrogen metabolism_Homo sapiens_hsa009103.40862672
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.13909224
4Complement and coagulation cascades_Homo sapiens_hsa046102.85297773
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61642458
6Arginine biosynthesis_Homo sapiens_hsa002202.41296891
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.37380616
8Sulfur metabolism_Homo sapiens_hsa009202.30358926
9Steroid biosynthesis_Homo sapiens_hsa001002.25617253
10Tryptophan metabolism_Homo sapiens_hsa003802.23493562
11Histidine metabolism_Homo sapiens_hsa003402.18297469
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15080354
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.13710689
14Retinol metabolism_Homo sapiens_hsa008302.10771330
15Staphylococcus aureus infection_Homo sapiens_hsa051502.10452592
16Chemical carcinogenesis_Homo sapiens_hsa052042.09939021
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.09840780
18Fatty acid elongation_Homo sapiens_hsa000622.02211592
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.01470193
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.92806411
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.87240266
22Small cell lung cancer_Homo sapiens_hsa052221.86303226
23Fatty acid degradation_Homo sapiens_hsa000711.84012753
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79750145
25Thyroid cancer_Homo sapiens_hsa052161.78059338
26Butanoate metabolism_Homo sapiens_hsa006501.76545714
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74522794
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74024100
29PPAR signaling pathway_Homo sapiens_hsa033201.63497691
30Dilated cardiomyopathy_Homo sapiens_hsa054141.61104044
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60754795
32Peroxisome_Homo sapiens_hsa041461.59125228
33Phenylalanine metabolism_Homo sapiens_hsa003601.52935283
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.52765477
35Fat digestion and absorption_Homo sapiens_hsa049751.46063719
36Bladder cancer_Homo sapiens_hsa052191.45794310
37Caffeine metabolism_Homo sapiens_hsa002321.43753361
38Bile secretion_Homo sapiens_hsa049761.41762420
39Starch and sucrose metabolism_Homo sapiens_hsa005001.40034563
40Tyrosine metabolism_Homo sapiens_hsa003501.38767943
41Fatty acid metabolism_Homo sapiens_hsa012121.37557220
42beta-Alanine metabolism_Homo sapiens_hsa004101.37319965
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36871402
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36331386
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35103709
46Tight junction_Homo sapiens_hsa045301.30918021
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28674278
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.28271228
49ECM-receptor interaction_Homo sapiens_hsa045121.28089987
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23266702
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21052083
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18642915
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18175342
54Propanoate metabolism_Homo sapiens_hsa006401.15609432
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14638954
56MicroRNAs in cancer_Homo sapiens_hsa052061.11996681
57Vitamin digestion and absorption_Homo sapiens_hsa049771.11344575
58Arginine and proline metabolism_Homo sapiens_hsa003301.07666792
59Wnt signaling pathway_Homo sapiens_hsa043101.07583715
60Thyroid hormone synthesis_Homo sapiens_hsa049181.06669418
61* Pathways in cancer_Homo sapiens_hsa052001.03209235
62Folate biosynthesis_Homo sapiens_hsa007900.99150930
63Glutathione metabolism_Homo sapiens_hsa004800.98667231
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.98612030
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.96313608
66ABC transporters_Homo sapiens_hsa020100.93641225
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88302979
68Protein digestion and absorption_Homo sapiens_hsa049740.82212669
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81128200
70Circadian rhythm_Homo sapiens_hsa047100.80525783
71Selenocompound metabolism_Homo sapiens_hsa004500.79544047
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.78919644
73Melanogenesis_Homo sapiens_hsa049160.78128304
74Endometrial cancer_Homo sapiens_hsa052130.76781155
75Melanoma_Homo sapiens_hsa052180.76311283
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75616505
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75441903
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72336014
79N-Glycan biosynthesis_Homo sapiens_hsa005100.68999957
80Pyruvate metabolism_Homo sapiens_hsa006200.65231885
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64190571
82Other glycan degradation_Homo sapiens_hsa005110.61738410
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61161761
84Linoleic acid metabolism_Homo sapiens_hsa005910.59061563
85Arachidonic acid metabolism_Homo sapiens_hsa005900.58204548
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55993196
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55905845
88FoxO signaling pathway_Homo sapiens_hsa040680.55858377
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53232120
90Chronic myeloid leukemia_Homo sapiens_hsa052200.52452094
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.51695663
92Renal cell carcinoma_Homo sapiens_hsa052110.51551921
93p53 signaling pathway_Homo sapiens_hsa041150.51131924
94Mineral absorption_Homo sapiens_hsa049780.50976682
95Lysine degradation_Homo sapiens_hsa003100.50872206
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.49867147
97Sphingolipid metabolism_Homo sapiens_hsa006000.49588212
98Prostate cancer_Homo sapiens_hsa052150.49529210
99Prion diseases_Homo sapiens_hsa050200.49110015
100Glycerolipid metabolism_Homo sapiens_hsa005610.47020273
101* TGF-beta signaling pathway_Homo sapiens_hsa043500.46974034
102Fatty acid biosynthesis_Homo sapiens_hsa000610.46297447
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44720788
104Ovarian steroidogenesis_Homo sapiens_hsa049130.40505637
105Fructose and mannose metabolism_Homo sapiens_hsa000510.38738326
106Malaria_Homo sapiens_hsa051440.36874901
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34275116
108Ether lipid metabolism_Homo sapiens_hsa005650.32197389
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32176828
110Metabolic pathways_Homo sapiens_hsa011000.32037585
111Amoebiasis_Homo sapiens_hsa051460.31963139
112Biosynthesis of amino acids_Homo sapiens_hsa012300.31515088
113Focal adhesion_Homo sapiens_hsa045100.30637779
114* Basal cell carcinoma_Homo sapiens_hsa052170.30369718
115Galactose metabolism_Homo sapiens_hsa000520.28114403
116* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27944625
117Carbon metabolism_Homo sapiens_hsa012000.26823995
118Vitamin B6 metabolism_Homo sapiens_hsa007500.25504320
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23857918
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.20454034
121Proteoglycans in cancer_Homo sapiens_hsa052050.18669039
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.18390730
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18290007
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16244995
125Pertussis_Homo sapiens_hsa051330.15870380
126Axon guidance_Homo sapiens_hsa043600.13713965
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.11670831
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10255427
129* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.09858869
130Renin-angiotensin system_Homo sapiens_hsa046140.09399149
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09162455
132* Hippo signaling pathway_Homo sapiens_hsa043900.08718237
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.08070044
134Adherens junction_Homo sapiens_hsa045200.06567478
135Insulin resistance_Homo sapiens_hsa049310.06537067
136* Hedgehog signaling pathway_Homo sapiens_hsa043400.06221699

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