ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	5.56971012
2	auditory behavior (GO:0031223)	4.93131813
3	presynaptic membrane organization (GO:0097090)	4.60832167
4	presynaptic membrane assembly (GO:0097105)	4.51141729
5	muscle organ morphogenesis (GO:0048644)	4.38543572
6	negative regulation of mast cell activation (GO:0033004)	4.29646341
7	photoreceptor cell differentiation (GO:0046530)	4.26953913
8	eye photoreceptor cell differentiation (GO:0001754)	4.26953913
9	righting reflex (GO:0060013)	4.12389906
10	protein localization to synapse (GO:0035418)	3.91919992
11	fucose catabolic process (GO:0019317)	3.90636370
12	L-fucose metabolic process (GO:0042354)	3.90636370
13	L-fucose catabolic process (GO:0042355)	3.90636370
14	positive regulation of synapse assembly (GO:0051965)	3.68015752
15	postsynaptic membrane organization (GO:0001941)	3.67271633
16	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.63354801
17	dopaminergic neuron differentiation (GO:0071542)	3.59668816
18	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	3.59257534
19	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.51216262
20	mechanosensory behavior (GO:0007638)	3.51095262
21	interleukin-6-mediated signaling pathway (GO:0070102)	3.50203428
22	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.49861969
23	smooth muscle tissue development (GO:0048745)	3.46531804
24	startle response (GO:0001964)	3.38944939
25	neuronal action potential propagation (GO:0019227)	3.37742225
26	lens fiber cell differentiation (GO:0070306)	3.33049480
27	establishment of protein localization to Golgi (GO:0072600)	3.29965143
28	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.26482007
29	glycosphingolipid biosynthetic process (GO:0006688)	3.24308108
30	glutamate receptor signaling pathway (GO:0007215)	3.21938993
31	retina layer formation (GO:0010842)	3.16483297
32	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.14906345
33	regulation of respiratory system process (GO:0044065)	3.14818693
34	negative regulation of neurotransmitter transport (GO:0051589)	3.10752069
35	astrocyte development (GO:0014002)	3.05958137
36	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.98587791
37	synapse assembly (GO:0007416)	2.98278577
38	negative regulation of fibroblast apoptotic process (GO:2000270)	2.96807183
39	dopamine transport (GO:0015872)	2.96269928
40	response to inactivity (GO:0014854)	2.96011989
41	regulation of synapse assembly (GO:0051963)	2.95054862
42	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	2.92595959
43	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	2.92595959
44	axonal fasciculation (GO:0007413)	2.91269402
45	protein localization to Golgi apparatus (GO:0034067)	2.90687251
46	protein targeting to Golgi (GO:0000042)	2.87595085
47	catecholamine transport (GO:0051937)	2.87527818
48	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.87498721
49	interkinetic nuclear migration (GO:0022027)	2.85590277
50	gamma-aminobutyric acid transport (GO:0015812)	2.80048317
51	cerebral cortex radially oriented cell migration (GO:0021799)	2.75593472
52	synaptic transmission, glutamatergic (GO:0035249)	2.75406384
53	atrial cardiac muscle cell action potential (GO:0086014)	2.75084999
54	tyrosine phosphorylation of STAT protein (GO:0007260)	2.74226021
55	response to auditory stimulus (GO:0010996)	2.73540626
56	dorsal/ventral axis specification (GO:0009950)	2.73280123
57	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.71951136
58	neurotransmitter-gated ion channel clustering (GO:0072578)	2.71678634
59	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.70238723
60	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.70238723
61	regulation of translation, ncRNA-mediated (GO:0045974)	2.70238723
62	calcium ion import (GO:0070509)	2.70144875
63	nucleus localization (GO:0051647)	2.67920872
64	intra-Golgi vesicle-mediated transport (GO:0006891)	2.67386686
65	membrane depolarization during action potential (GO:0086010)	2.66063272
66	regulation of cAMP-dependent protein kinase activity (GO:2000479)	2.65790783
67	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.65109356
68	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.63641770
69	neuron-neuron synaptic transmission (GO:0007270)	2.62953184
70	regulation of cell communication by electrical coupling (GO:0010649)	2.62335032
71	regulation of hexokinase activity (GO:1903299)	2.61861206
72	regulation of glucokinase activity (GO:0033131)	2.61861206
73	SMAD protein complex assembly (GO:0007183)	2.60558868
74	regulation of potassium ion transmembrane transporter activity (GO:1901016)	2.59888648
75	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.59232612
76	dermatan sulfate biosynthetic process (GO:0030208)	2.56678115
77	multicellular organism reproduction (GO:0032504)	2.56665010
78	positive regulation of sodium ion transport (GO:0010765)	2.53762726
79	prostate gland growth (GO:0060736)	2.51697098
80	ADP metabolic process (GO:0046031)	2.51685788
81	chemosensory behavior (GO:0007635)	2.51563989
82	nucleobase catabolic process (GO:0046113)	2.50745190
83	estrogen biosynthetic process (GO:0006703)	2.50724327
84	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	2.50349707
85	regulation of respiratory gaseous exchange (GO:0043576)	2.49214911
86	peristalsis (GO:0030432)	2.48815909
87	nerve growth factor signaling pathway (GO:0038180)	2.48601587
88	membrane assembly (GO:0071709)	2.47411126
89	early endosome to late endosome transport (GO:0045022)	2.46604426
90	sialylation (GO:0097503)	2.44696735
91	urinary tract smooth muscle contraction (GO:0014848)	2.44366225
92	neuron recognition (GO:0008038)	2.43635894
93	reflex (GO:0060004)	2.43276795
94	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.42031904
95	ubiquinone metabolic process (GO:0006743)	2.41901849
96	cochlea development (GO:0090102)	2.41260134
97	protein-chromophore linkage (GO:0018298)	2.41025126
98	action potential (GO:0001508)	2.40605020
99	lens morphogenesis in camera-type eye (GO:0002089)	2.40302830
100	positive regulation of muscle hypertrophy (GO:0014742)	2.39491723

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.50415587
2	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	3.26824129
3	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.92593082
4	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.84158957
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.80690253
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.67803768
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.54093747
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.35701322
9	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.32069692
10	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.26498962
11	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.26264803
12	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.18423213
13	SMAD4_21799915_ChIP-Seq_A2780_Human	2.15191898
14	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.11569946
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10996436
16	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.08719823
17	EZH2_22144423_ChIP-Seq_EOC_Human	2.05482171
18	P300_19829295_ChIP-Seq_ESCs_Human	2.01512288
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.90890123
20	FUS_26573619_Chip-Seq_HEK293_Human	1.85936923
21	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.84975265
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.81446048
23	STAT3_23295773_ChIP-Seq_U87_Human	1.78116446
24	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.75152524
25	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.74334448
26	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.72679448
27	EWS_26573619_Chip-Seq_HEK293_Human	1.67717396
28	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.65815612
29	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.64776502
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.64442092
31	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.64329873
32	IGF1R_20145208_ChIP-Seq_DFB_Human	1.63131839
33	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.63127197
34	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.61925202
35	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.61644668
36	ZNF274_21170338_ChIP-Seq_K562_Hela	1.61309546
37	TCF4_23295773_ChIP-Seq_U87_Human	1.61275550
38	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.59767653
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.57217548
40	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.56039022
41	AR_25329375_ChIP-Seq_VCAP_Human	1.54783676
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.53657273
43	AHR_22903824_ChIP-Seq_MCF-7_Human	1.51188780
44	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.49983982
45	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.49402700
46	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.49402700
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.47755120
48	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.45274737
49	AR_21572438_ChIP-Seq_LNCaP_Human	1.44801543
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44064181
51	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.43386856
52	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.43007290
53	VDR_22108803_ChIP-Seq_LS180_Human	1.42711204
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42658810
55	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.42312196
56	TP53_18474530_ChIP-ChIP_U2OS_Human	1.42271048
57	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.41650625
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40352750
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39531916
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.39531916
61	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.38942025
62	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.34306696
63	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.34259250
64	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.34230071
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.34084080
66	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32982738
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30449653
68	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.29353292
69	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28537848
70	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28145102
71	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28145102
72	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.27734292
73	P53_22387025_ChIP-Seq_ESCs_Mouse	1.27660979
74	CJUN_26792858_Chip-Seq_BT549_Human	1.27452907
75	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.26027855
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24229860
77	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.22049196
78	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.18997675
79	REST_21632747_ChIP-Seq_MESCs_Mouse	1.18985791
80	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.18960052
81	KDM2B_26808549_Chip-Seq_REH_Human	1.18635843
82	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.18457035
83	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.18305096
84	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.17083454
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.15850366
86	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.15185533
87	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.14741125
88	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.14200410
89	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13558394
90	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.13194431
91	TP53_16413492_ChIP-PET_HCT116_Human	1.12028792
92	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.11955092
93	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.10997053
94	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.10799944
95	DROSHA_22980978_ChIP-Seq_HELA_Human	1.09923505
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09571626
97	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.09001892
98	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.08984660
99	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08637870
100	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07860851

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	6.94422482
2	MP0002638_abnormal_pupillary_reflex	3.09764833
3	MP0004270_analgesia	2.99238202
4	MP0002735_abnormal_chemical_nociception	2.95977289
5	MP0003646_muscle_fatigue	2.82538098
6	MP0004859_abnormal_synaptic_plasticity	2.76695462
7	MP0009046_muscle_twitch	2.60816908
8	MP0001968_abnormal_touch/_nociception	2.56149672
9	MP0002736_abnormal_nociception_after	2.50143007
10	MP0005423_abnormal_somatic_nervous	2.45068262
11	MP0008057_abnormal_DNA_replication	2.39050199
12	MP0001346_abnormal_lacrimal_gland	2.26936505
13	MP0001905_abnormal_dopamine_level	2.24665931
14	MP0002734_abnormal_mechanical_nocicepti	2.12863931
15	MP0010386_abnormal_urinary_bladder	1.94643923
16	MP0002909_abnormal_adrenal_gland	1.91704024
17	MP0003635_abnormal_synaptic_transmissio	1.87581322
18	MP0001486_abnormal_startle_reflex	1.87093102
19	MP0002733_abnormal_thermal_nociception	1.84108601
20	MP0006276_abnormal_autonomic_nervous	1.83552594
21	MP0001984_abnormal_olfaction	1.82367850
22	MP0004145_abnormal_muscle_electrophysio	1.81211244
23	MP0005386_behavior/neurological_phenoty	1.81072644
24	MP0004924_abnormal_behavior	1.81072644
25	MP0005187_abnormal_penis_morphology	1.80009799
26	MP0001529_abnormal_vocalization	1.70863191
27	MP0002272_abnormal_nervous_system	1.67811474
28	MP0002063_abnormal_learning/memory/cond	1.64762281
29	MP0003787_abnormal_imprinting	1.64277874
30	MP0002837_dystrophic_cardiac_calcinosis	1.63827874
31	MP0002067_abnormal_sensory_capabilities	1.62297912
32	MP0001299_abnormal_eye_distance/	1.60474360
33	MP0003195_calcinosis	1.60214147
34	MP0002572_abnormal_emotion/affect_behav	1.58687794
35	MP0000013_abnormal_adipose_tissue	1.49774512
36	MP0001502_abnormal_circadian_rhythm	1.47499494
37	MP0001970_abnormal_pain_threshold	1.46385858
38	MP0009697_abnormal_copulation	1.45094862
39	MP0003879_abnormal_hair_cell	1.45057581
40	MP0001440_abnormal_grooming_behavior	1.44844738
41	MP0004215_abnormal_myocardial_fiber	1.44826687
42	MP0003045_fibrosis	1.41459197
43	MP0001501_abnormal_sleep_pattern	1.39299922
44	MP0002168_other_aberrant_phenotype	1.37106383
45	MP0003123_paternal_imprinting	1.30541172
46	MP0002557_abnormal_social/conspecific_i	1.24748168
47	MP0003137_abnormal_impulse_conducting	1.24514278
48	MP0002064_seizures	1.24337324
49	MP0009745_abnormal_behavioral_response	1.23822074
50	MP0003950_abnormal_plasma_membrane	1.18060127
51	MP0003880_abnormal_central_pattern	1.17774197
52	MP0003121_genomic_imprinting	1.15701553
53	MP0003890_abnormal_embryonic-extraembry	1.15424817
54	MP0000751_myopathy	1.13100835
55	MP0005551_abnormal_eye_electrophysiolog	1.12995258
56	MP0002971_abnormal_brown_adipose	1.12371341
57	MP0003633_abnormal_nervous_system	1.11975805
58	MP0004036_abnormal_muscle_relaxation	1.11109936
59	MP0005670_abnormal_white_adipose	1.10509012
60	MP0000747_muscle_weakness	1.07451055
61	MP0000778_abnormal_nervous_system	1.07418478
62	MP0004130_abnormal_muscle_cell	1.06329984
63	MP0003959_abnormal_lean_body	1.04692845
64	MP0000749_muscle_degeneration	1.04220442
65	MP0000566_synostosis	1.03903086
66	MP0000003_abnormal_adipose_tissue	1.01657034
67	MP0005253_abnormal_eye_physiology	1.00245772
68	MP0003122_maternal_imprinting	0.99107551
69	MP0004084_abnormal_cardiac_muscle	0.98992256
70	MP0003283_abnormal_digestive_organ	0.98138941
71	MP0005620_abnormal_muscle_contractility	0.95617759
72	MP0005645_abnormal_hypothalamus_physiol	0.95024133
73	MP0002876_abnormal_thyroid_physiology	0.94475500
74	MP0002229_neurodegeneration	0.91252684
75	MP0002184_abnormal_innervation	0.90430946
76	MP0002882_abnormal_neuron_morphology	0.89098850
77	MP0004085_abnormal_heartbeat	0.87981931
78	MP0002822_catalepsy	0.87761014
79	MP0004811_abnormal_neuron_physiology	0.84241370
80	MP0003631_nervous_system_phenotype	0.82468916
81	MP0002066_abnormal_motor_capabilities/c	0.81570818
82	MP0000427_abnormal_hair_cycle	0.81079384
83	MP0002938_white_spotting	0.78423806
84	MP0004134_abnormal_chest_morphology	0.76265416
85	MP0000383_abnormal_hair_follicle	0.76137904
86	MP0005266_abnormal_metabolism	0.76135645
87	MP0005448_abnormal_energy_balance	0.75809577
88	MP0002106_abnormal_muscle_physiology	0.75372992
89	MP0001485_abnormal_pinna_reflex	0.74680447
90	MP0000750_abnormal_muscle_regeneration	0.73444935
91	MP0005535_abnormal_body_temperature	0.71243195
92	MP0004142_abnormal_muscle_tone	0.71050724
93	MP0003937_abnormal_limbs/digits/tail_de	0.69531720
94	MP0000639_abnormal_adrenal_gland	0.69346774
95	MP0000372_irregular_coat_pigmentation	0.69011703
96	MP0004510_myositis	0.68028398
97	MP0005595_abnormal_vascular_smooth	0.64745861
98	MP0005395_other_phenotype	0.64244794
99	MP0004885_abnormal_endolymph	0.64168091
100	MP0003279_aneurysm	0.63644514

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	5.53072512
2	Focal motor seizures (HP:0011153)	4.23214206
3	Absent speech (HP:0001344)	4.16021374
4	Broad-based gait (HP:0002136)	4.01283247
5	Difficulty running (HP:0009046)	3.79167983
6	Pheochromocytoma (HP:0002666)	3.46085069
7	Nephronophthisis (HP:0000090)	3.40284518
8	Hypothermia (HP:0002045)	3.39941348
9	Anterior segment dysgenesis (HP:0007700)	3.35485124
10	EEG with generalized epileptiform discharges (HP:0011198)	3.22977881
11	Epileptiform EEG discharges (HP:0011182)	3.15412317
12	Hypsarrhythmia (HP:0002521)	3.12866737
13	Fair hair (HP:0002286)	3.12673828
14	Abnormality of the renal medulla (HP:0100957)	2.99663664
15	Pancreatic cysts (HP:0001737)	2.99436534
16	Distal arthrogryposis (HP:0005684)	2.97440631
17	Limb dystonia (HP:0002451)	2.90902075
18	Drooling (HP:0002307)	2.86984786
19	Poor eye contact (HP:0000817)	2.83490860
20	Nemaline bodies (HP:0003798)	2.80333760
21	Pancreatic fibrosis (HP:0100732)	2.76895003
22	Neuroendocrine neoplasm (HP:0100634)	2.76834745
23	Decreased circulating renin level (HP:0003351)	2.69096943
24	Biliary tract neoplasm (HP:0100574)	2.64696016
25	Abnormality of the anterior chamber (HP:0000593)	2.63248213
26	Rimmed vacuoles (HP:0003805)	2.62427717
27	Excessive salivation (HP:0003781)	2.60881241
28	Tracheomalacia (HP:0002779)	2.60244196
29	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.59683830
30	Increased density of long bones (HP:0006392)	2.57559802
31	Bifid tongue (HP:0010297)	2.57347754
32	Generalized hypopigmentation of hair (HP:0011358)	2.53215419
33	Febrile seizures (HP:0002373)	2.52101684
34	Muscle fiber inclusion bodies (HP:0100299)	2.52100675
35	Gaze-evoked nystagmus (HP:0000640)	2.51722929
36	Tented upper lip vermilion (HP:0010804)	2.51164367
37	Protruding tongue (HP:0010808)	2.50065335
38	Focal seizures (HP:0007359)	2.47308671
39	Epileptic encephalopathy (HP:0200134)	2.46380958
40	Overgrowth (HP:0001548)	2.41334685
41	Exotropia (HP:0000577)	2.31481292
42	Hypoplastic labia majora (HP:0000059)	2.29706150
43	True hermaphroditism (HP:0010459)	2.28141865
44	Upper limb muscle weakness (HP:0003484)	2.27256323
45	Stomach cancer (HP:0012126)	2.27242742
46	Neoplasm of the small intestine (HP:0100833)	2.24769733
47	Gait imbalance (HP:0002141)	2.24756925
48	Abnormality of the labia majora (HP:0012881)	2.22064428
49	Dyskinesia (HP:0100660)	2.13292352
50	Short chin (HP:0000331)	2.13274003
51	Abnormal social behavior (HP:0012433)	2.12367558
52	Impaired social interactions (HP:0000735)	2.12367558
53	Genital tract atresia (HP:0001827)	2.10987150
54	Vaginal atresia (HP:0000148)	2.10860725
55	Hamartoma of the eye (HP:0010568)	2.08349294
56	Congenital primary aphakia (HP:0007707)	2.07769373
57	Dialeptic seizures (HP:0011146)	2.06939414
58	Medial flaring of the eyebrow (HP:0010747)	2.05212981
59	Postnatal microcephaly (HP:0005484)	2.04803197
60	Astrocytoma (HP:0009592)	2.03918673
61	Abnormality of the astrocytes (HP:0100707)	2.03918673
62	Hypoplastic iliac wings (HP:0002866)	2.02222801
63	Furrowed tongue (HP:0000221)	2.01713021
64	Smooth philtrum (HP:0000319)	2.01538715
65	Truncal obesity (HP:0001956)	1.98192738
66	Insulin-resistant diabetes mellitus (HP:0000831)	1.97528997
67	Abnormality of the renal cortex (HP:0011035)	1.96344642
68	Widely spaced teeth (HP:0000687)	1.95639080
69	Fibular aplasia (HP:0002990)	1.95627730
70	Volvulus (HP:0002580)	1.94424815
71	Diastasis recti (HP:0001540)	1.93703930
72	Poor coordination (HP:0002370)	1.93104132
73	Cone-rod dystrophy (HP:0000548)	1.92998684
74	Menstrual irregularities (HP:0000858)	1.92028832
75	Neoplasm of the rectum (HP:0100743)	1.91978164
76	Blue irides (HP:0000635)	1.91513838
77	Absence seizures (HP:0002121)	1.90022497
78	Nephrogenic diabetes insipidus (HP:0009806)	1.89789605
79	Tubular atrophy (HP:0000092)	1.89700421
80	Abnormality of midbrain morphology (HP:0002418)	1.89280139
81	Molar tooth sign on MRI (HP:0002419)	1.89280139
82	Prominent supraorbital ridges (HP:0000336)	1.87662568
83	Abnormality of the left ventricular outflow tract (HP:0011103)	1.86360632
84	Subaortic stenosis (HP:0001682)	1.86360632
85	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.83617294
86	Soft skin (HP:0000977)	1.81909618
87	Generalized tonic-clonic seizures (HP:0002069)	1.80361189
88	Neoplasm of the heart (HP:0100544)	1.79660604
89	Thin upper lip vermilion (HP:0000219)	1.78792145
90	Neoplasm of the peripheral nervous system (HP:0100007)	1.76998553
91	Chorioretinal atrophy (HP:0000533)	1.75613710
92	Abnormality of the ischium (HP:0003174)	1.75062400
93	Tubulointerstitial nephritis (HP:0001970)	1.74488684
94	Muscular hypotonia of the trunk (HP:0008936)	1.71542451
95	Attenuation of retinal blood vessels (HP:0007843)	1.69639614
96	Left ventricular hypertrophy (HP:0001712)	1.69228139
97	Papillary thyroid carcinoma (HP:0002895)	1.69059572
98	Highly arched eyebrow (HP:0002553)	1.68437950
99	Cystic liver disease (HP:0006706)	1.68069817
100	Progressive cerebellar ataxia (HP:0002073)	1.67685748

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	7.44278314
2	ACVR1B	3.57316384
3	MARK1	3.48178758
4	FRK	3.30495093
5	OBSCN	3.13420121
6	WNK3	2.89416135
7	MAP3K4	2.43687302
8	BMPR1B	2.28951251
9	FER	2.22480532
10	PHKG2	1.87349413
11	PHKG1	1.87349413
12	CSNK1G2	1.86921063
13	CSNK1G3	1.85955113
14	NTRK3	1.72469628
15	MAPK13	1.69166319
16	CSNK1G1	1.59922924
17	PIK3CG	1.50998204
18	PAK3	1.48440504
19	NTRK2	1.45251581
20	MAP3K2	1.41446033
21	MAP2K7	1.36968355
22	NEK1	1.34522173
23	SGK2	1.32277374
24	PBK	1.28942915
25	MAPKAPK5	1.24401200
26	MST4	1.16265866
27	CAMK2D	1.16214456
28	DMPK	1.15560183
29	LATS1	1.15517334
30	TNIK	1.12269188
31	MAP2K4	1.10146056
32	ERBB3	1.06854758
33	CSNK1A1L	1.05690186
34	NUAK1	1.02943798
35	PIK3CA	1.01589132
36	MAP3K7	0.99023378
37	SGK494	0.98281759
38	SGK223	0.98281759
39	OXSR1	0.94339080
40	CAMK2B	0.92249505
41	ADRBK2	0.91698643
42	CAMKK2	0.87328942
43	GRK1	0.86218119
44	AKT3	0.85909722
45	MYLK	0.84017698
46	CDK12	0.82465780
47	SGK3	0.79135709
48	TGFBR1	0.78266297
49	PRKCE	0.74284488
50	PRKAA2	0.71881893
51	MAP2K6	0.71704669
52	TRPM7	0.70778740
53	MAP3K12	0.70117561
54	CAMK2A	0.68871779
55	DAPK2	0.66973912
56	MET	0.66202790
57	CAMK4	0.65012015
58	MKNK2	0.63981741
59	CCNB1	0.61565914
60	SGK1	0.61417125
61	PDK2	0.61353355
62	PRKAA1	0.60933524
63	CAMK2G	0.59545017
64	MST1R	0.57125509
65	MELK	0.56931784
66	EPHA4	0.56810102
67	PINK1	0.54885506
68	MINK1	0.53633329
69	STK38	0.53605390
70	CSNK1E	0.49036520
71	PRKCG	0.47739668
72	CDK3	0.47648494
73	PRKG1	0.46333587
74	PRKACA	0.45947722
75	MAP4K2	0.43827195
76	NEK9	0.43363746
77	ROCK1	0.42990360
78	ADRBK1	0.42810530
79	CDK19	0.42539359
80	MAPK10	0.42405137
81	MAP2K1	0.42295643
82	CSNK1D	0.41078540
83	CAMK1	0.39739480
84	ZAK	0.39473789
85	CSNK1A1	0.39376930
86	CDK5	0.38108302
87	MARK2	0.37712713
88	BCR	0.36256481
89	PKN1	0.35782807
90	PRKACB	0.33890421
91	STK39	0.33735551
92	RPS6KA3	0.33714489
93	MUSK	0.29052606
94	PDGFRB	0.28746939
95	MAPK8	0.28628572
96	BRD4	0.28546829
97	TGFBR2	0.28036646
98	STK11	0.27285457
99	DYRK2	0.27152130
100	DYRK3	0.25972023

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.39821628
2	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.32661293
3	Circadian rhythm_Homo sapiens_hsa04710	2.90335662
4	Glutamatergic synapse_Homo sapiens_hsa04724	2.39651035
5	Amphetamine addiction_Homo sapiens_hsa05031	2.39493174
6	Cocaine addiction_Homo sapiens_hsa05030	2.29477628
7	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.23881765
8	Circadian entrainment_Homo sapiens_hsa04713	2.18010263
9	Taste transduction_Homo sapiens_hsa04742	1.99950364
10	Dopaminergic synapse_Homo sapiens_hsa04728	1.94003998
11	Long-term depression_Homo sapiens_hsa04730	1.85542091
12	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.84427565
13	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.78601413
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.77170798
15	GABAergic synapse_Homo sapiens_hsa04727	1.70762087
16	Insulin secretion_Homo sapiens_hsa04911	1.67261431
17	Serotonergic synapse_Homo sapiens_hsa04726	1.60131276
18	Adherens junction_Homo sapiens_hsa04520	1.55712082
19	Renin secretion_Homo sapiens_hsa04924	1.49213925
20	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.44751971
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.37638978
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.37016049
23	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.36874512
24	Butanoate metabolism_Homo sapiens_hsa00650	1.35255668
25	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.34692507
26	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.33665630
27	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.32303151
28	Morphine addiction_Homo sapiens_hsa05032	1.31272803
29	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.29923732
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.29296594
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.28883303
32	Salivary secretion_Homo sapiens_hsa04970	1.25775317
33	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.25432813
34	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.17493290
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.16803226
36	Calcium signaling pathway_Homo sapiens_hsa04020	1.11625204
37	Type II diabetes mellitus_Homo sapiens_hsa04930	1.10228400
38	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.09217136
39	Phototransduction_Homo sapiens_hsa04744	1.05189675
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.04129069
41	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.01662346
42	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00064598
43	ABC transporters_Homo sapiens_hsa02010	0.98905619
44	Tight junction_Homo sapiens_hsa04530	0.97813577
45	Lysine degradation_Homo sapiens_hsa00310	0.92208415
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.91962906
47	Cardiac muscle contraction_Homo sapiens_hsa04260	0.91864270
48	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.90070636
49	cAMP signaling pathway_Homo sapiens_hsa04024	0.90028216
50	Linoleic acid metabolism_Homo sapiens_hsa00591	0.89333941
51	Long-term potentiation_Homo sapiens_hsa04720	0.88610174
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.84828102
53	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.82901774
54	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.82839834
55	Cholinergic synapse_Homo sapiens_hsa04725	0.82755754
56	Regulation of autophagy_Homo sapiens_hsa04140	0.82491698
57	Gastric acid secretion_Homo sapiens_hsa04971	0.80543745
58	Selenocompound metabolism_Homo sapiens_hsa00450	0.79350937
59	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.79346683
60	Gap junction_Homo sapiens_hsa04540	0.78013452
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.77011000
62	Hippo signaling pathway_Homo sapiens_hsa04390	0.74359657
63	Olfactory transduction_Homo sapiens_hsa04740	0.70848731
64	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.68647077
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68392209
66	Basal transcription factors_Homo sapiens_hsa03022	0.67591245
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67030909
68	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.64891230
69	Oocyte meiosis_Homo sapiens_hsa04114	0.64350571
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.64276046
71	FoxO signaling pathway_Homo sapiens_hsa04068	0.63730816
72	ECM-receptor interaction_Homo sapiens_hsa04512	0.61367049
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60046680
74	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.59669654
75	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.59656311
76	Fanconi anemia pathway_Homo sapiens_hsa03460	0.58028934
77	Histidine metabolism_Homo sapiens_hsa00340	0.57068912
78	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.56531707
79	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.55429344
80	Alcoholism_Homo sapiens_hsa05034	0.51680660
81	GnRH signaling pathway_Homo sapiens_hsa04912	0.50484021
82	Focal adhesion_Homo sapiens_hsa04510	0.49828365
83	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.49412283
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47272965
85	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.46254170
86	mTOR signaling pathway_Homo sapiens_hsa04150	0.45964893
87	Ras signaling pathway_Homo sapiens_hsa04014	0.42861333
88	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.42162622
89	Axon guidance_Homo sapiens_hsa04360	0.40899291
90	Wnt signaling pathway_Homo sapiens_hsa04310	0.40524317
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40235567
92	Fatty acid degradation_Homo sapiens_hsa00071	0.36593124
93	Pancreatic secretion_Homo sapiens_hsa04972	0.36405680
94	Platelet activation_Homo sapiens_hsa04611	0.35590582
95	Insulin resistance_Homo sapiens_hsa04931	0.35185292
96	MAPK signaling pathway_Homo sapiens_hsa04010	0.34098213
97	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.33711903
98	AMPK signaling pathway_Homo sapiens_hsa04152	0.33104018
99	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.32983280
100	Melanoma_Homo sapiens_hsa05218	0.29855826

BMP2KL

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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