BMP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gamma-aminobutyric acid transport (GO:0015812)8.12808652
2pyrimidine nucleobase catabolic process (GO:0006208)6.27478400
3polyketide metabolic process (GO:0030638)5.74646821
4doxorubicin metabolic process (GO:0044598)5.74646821
5daunorubicin metabolic process (GO:0044597)5.74646821
6nucleobase catabolic process (GO:0046113)5.57404401
7mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.80018836
8positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.80018836
9negative regulation of oligodendrocyte differentiation (GO:0048715)4.61063183
10head development (GO:0060322)4.03229310
11reflex (GO:0060004)3.94238374
12glycosphingolipid biosynthetic process (GO:0006688)3.93500105
13protein K11-linked deubiquitination (GO:0035871)3.91955610
14positive regulation of mitochondrial fission (GO:0090141)3.88453589
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.88202821
16vocalization behavior (GO:0071625)3.74759985
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.74622879
18cornea development in camera-type eye (GO:0061303)3.68516262
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.67971206
20calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.61969874
21negative regulation of synaptic transmission, GABAergic (GO:0032229)3.61032614
22establishment of mitochondrion localization (GO:0051654)3.52398115
23protein-cofactor linkage (GO:0018065)3.47621981
24sequestering of extracellular ligand from receptor (GO:0035581)3.45850794
25aminoglycoside antibiotic metabolic process (GO:0030647)3.43715571
26positive regulation of amino acid transport (GO:0051957)3.39007112
27regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.36559186
28regulation of oligodendrocyte differentiation (GO:0048713)3.35484240
29regulation of non-canonical Wnt signaling pathway (GO:2000050)3.32694695
30synapse assembly (GO:0007416)3.32249414
31L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.31907911
32regulation of feeding behavior (GO:0060259)3.31511519
33auditory receptor cell stereocilium organization (GO:0060088)3.30940287
34regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.27988964
35positive regulation of oligodendrocyte differentiation (GO:0048714)3.27329884
36protein localization to cilium (GO:0061512)3.27217132
37regulation of glutamate receptor signaling pathway (GO:1900449)3.27145506
38water-soluble vitamin biosynthetic process (GO:0042364)3.26590484
39behavioral response to nicotine (GO:0035095)3.26086302
40lateral sprouting from an epithelium (GO:0060601)3.25870219
41positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21568688
42mesenchymal-epithelial cell signaling (GO:0060638)3.21411779
43retinal cone cell development (GO:0046549)3.19739026
44positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.19387648
45succinate metabolic process (GO:0006105)3.17681989
46regulation of alkaline phosphatase activity (GO:0010692)3.14274080
47synaptic vesicle exocytosis (GO:0016079)3.12752836
48behavioral response to ethanol (GO:0048149)3.10368183
49cell proliferation involved in kidney development (GO:0072111)3.08815048
50presynaptic membrane assembly (GO:0097105)3.08213614
51neurotransmitter secretion (GO:0007269)3.07681022
52extracellular regulation of signal transduction (GO:1900115)3.06032835
53extracellular negative regulation of signal transduction (GO:1900116)3.06032835
54positive regulation of developmental pigmentation (GO:0048087)3.05688192
55cilium or flagellum-dependent cell motility (GO:0001539)3.04854282
56prostate gland growth (GO:0060736)3.03439422
57limb bud formation (GO:0060174)3.02625526
58cell proliferation involved in metanephros development (GO:0072203)3.02286539
59proline transport (GO:0015824)3.00613620
60fucose catabolic process (GO:0019317)3.00602175
61L-fucose metabolic process (GO:0042354)3.00602175
62L-fucose catabolic process (GO:0042355)3.00602175
63glycine transport (GO:0015816)2.98275450
64detection of molecule of bacterial origin (GO:0032490)2.97834512
65axoneme assembly (GO:0035082)2.97256403
66hippocampus development (GO:0021766)2.96941261
67inner ear receptor stereocilium organization (GO:0060122)2.95195794
68mesenchymal cell differentiation (GO:0048762)2.94081748
69DNA integration (GO:0015074)2.93734156
70negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.90135175
71epithelial cell differentiation involved in kidney development (GO:0035850)2.89472973
72cellular response to leptin stimulus (GO:0044320)2.88824574
73positive regulation of synapse maturation (GO:0090129)2.87138615
74startle response (GO:0001964)2.86817355
75regulation of pigment cell differentiation (GO:0050932)2.86657658
76positive regulation of phosphatase activity (GO:0010922)2.86255623
77bone trabecula formation (GO:0060346)2.85784353
78regulation of synapse maturation (GO:0090128)2.83382710
79regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.81678508
80neural tube formation (GO:0001841)2.80684168
81regulation of cilium movement (GO:0003352)2.80589360
82olfactory bulb development (GO:0021772)2.79892028
83axonemal dynein complex assembly (GO:0070286)2.79037448
84axon extension involved in axon guidance (GO:0048846)2.79031239
85neuron projection extension involved in neuron projection guidance (GO:1902284)2.79031239
86neurotransmitter biosynthetic process (GO:0042136)2.78979903
87sulfation (GO:0051923)2.76994537
88amino acid salvage (GO:0043102)2.76432686
89L-methionine salvage (GO:0071267)2.76432686
90L-methionine biosynthetic process (GO:0071265)2.76432686
91regulation of synaptic vesicle exocytosis (GO:2000300)2.76367890
92regulation of mitochondrial fission (GO:0090140)2.74785392
93axonal fasciculation (GO:0007413)2.73650841
94epithelial cilium movement (GO:0003351)2.72880827
95negative regulation of keratinocyte proliferation (GO:0010839)2.72465040
96positive regulation of heat generation (GO:0031652)2.71503629
97serotonin receptor signaling pathway (GO:0007210)2.69837086
98glomerulus development (GO:0032835)2.69749082
99neuron cell-cell adhesion (GO:0007158)2.69381228
100gamma-aminobutyric acid signaling pathway (GO:0007214)2.68837373
101neurotransmitter metabolic process (GO:0042133)2.68814265
102long term synaptic depression (GO:0060292)2.68494699
103regulation of neurotransmitter levels (GO:0001505)2.67400705
104ionotropic glutamate receptor signaling pathway (GO:0035235)2.65674526
105sialylation (GO:0097503)2.64238140
106negative regulation of axon extension involved in axon guidance (GO:0048843)2.63628550
107adult feeding behavior (GO:0008343)2.63612374
108detection of calcium ion (GO:0005513)2.63007135
109cilium organization (GO:0044782)2.62472435
110mesonephros development (GO:0001823)2.62164530
111protein polyglutamylation (GO:0018095)2.60932928
112positive regulation of synapse assembly (GO:0051965)2.60788949
113somite development (GO:0061053)2.60123328
114ganglion development (GO:0061548)2.60021406
115negative regulation of stem cell proliferation (GO:2000647)2.58977921
116C4-dicarboxylate transport (GO:0015740)2.58952798
117primary amino compound metabolic process (GO:1901160)2.58346677
118positive regulation of mitochondrial membrane permeability (GO:0035794)2.58235630
119postsynaptic membrane organization (GO:0001941)2.57811300
120serotonin metabolic process (GO:0042428)2.57810160
121adaptation of signaling pathway (GO:0023058)2.57761105
122regulation of sarcomere organization (GO:0060297)2.57551367
123cilium movement (GO:0003341)2.57144442
124regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.56169382
125positive regulation of neurotransmitter secretion (GO:0001956)2.55295075
126sulfate transmembrane transport (GO:1902358)2.55169043
127kidney morphogenesis (GO:0060993)2.54883945
128homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.54241110
129cilium assembly (GO:0042384)2.54073583
130positive regulation of potassium ion transmembrane transport (GO:1901381)2.53499070
131glutamate secretion (GO:0014047)2.53175842
132presynaptic membrane organization (GO:0097090)2.52941917
133glial cell proliferation (GO:0014009)2.52885783
134cellular ketone body metabolic process (GO:0046950)2.52634275
135regulation of keratinocyte proliferation (GO:0010837)2.52423977
136negative regulation of mast cell activation (GO:0033004)2.49981067
137ribonucleoprotein complex disassembly (GO:0032988)2.49501843
138neuron recognition (GO:0008038)2.49329334
139negative regulation of systemic arterial blood pressure (GO:0003085)2.49265164
140craniofacial suture morphogenesis (GO:0097094)2.48916365
141mesenchymal cell differentiation involved in kidney development (GO:0072161)2.48653948
142mesenchymal cell differentiation involved in renal system development (GO:2001012)2.48653948
143neuron-neuron synaptic transmission (GO:0007270)2.48272045
144neurotransmitter-gated ion channel clustering (GO:0072578)2.47568211
145urinary tract smooth muscle contraction (GO:0014848)2.45890137
146dicarboxylic acid catabolic process (GO:0043649)2.45391566
147short-term memory (GO:0007614)2.45191786
148regulation of collateral sprouting (GO:0048670)2.44587300
149glycolipid biosynthetic process (GO:0009247)2.44424658
150positive regulation of uterine smooth muscle contraction (GO:0070474)2.44381346
151positive regulation of organic acid transport (GO:0032892)2.43739016
152negative regulation of axon guidance (GO:1902668)2.43378925
153long-term synaptic potentiation (GO:0060291)2.43016253
154protein localization to synapse (GO:0035418)2.42557348
155glutamate receptor signaling pathway (GO:0007215)2.41787760
156neuron remodeling (GO:0016322)2.38265827
157positive regulation of cardiac muscle cell differentiation (GO:2000727)2.37893327
158synaptic transmission, glutamatergic (GO:0035249)2.37485580
159response to pheromone (GO:0019236)2.37342576
160regulation of cell communication by electrical coupling (GO:0010649)2.36805977
161regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.36486865
162regulation of neurotransmitter secretion (GO:0046928)2.35117018
163negative chemotaxis (GO:0050919)2.33908689
164opioid receptor signaling pathway (GO:0038003)2.33766531
165regulation of short-term neuronal synaptic plasticity (GO:0048172)2.33280410
166cell differentiation involved in kidney development (GO:0061005)2.32879865
167positive regulation of vascular permeability (GO:0043117)2.31795866
168regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.30554892
169cAMP catabolic process (GO:0006198)2.29670536
170regulation of synaptic vesicle transport (GO:1902803)2.29296727
171negative regulation of synaptic transmission (GO:0050805)2.29126803
172regulation of fever generation (GO:0031620)2.28776523
173central nervous system projection neuron axonogenesis (GO:0021952)2.28713940
174G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.25642609
175regulation of cardiac muscle cell differentiation (GO:2000725)2.25215992
176bicarbonate transport (GO:0015701)2.24015225
177regulation of axon extension involved in axon guidance (GO:0048841)2.23957353
178exogenous drug catabolic process (GO:0042738)2.23167331
179mesenchymal cell proliferation (GO:0010463)2.22491072
180regulation of excitatory postsynaptic membrane potential (GO:0060079)2.21624578
181positive regulation of synaptic transmission, GABAergic (GO:0032230)2.21559894
182cerebral cortex radially oriented cell migration (GO:0021799)2.20912096
183positive regulation of neurotransmitter transport (GO:0051590)2.19851932
184regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.18754219
185synaptic vesicle endocytosis (GO:0048488)2.18235091

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.50621870
2GBX2_23144817_ChIP-Seq_PC3_Human3.95008251
3ZNF274_21170338_ChIP-Seq_K562_Hela3.90412661
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.50593054
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09831709
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.00407347
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.69679718
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62920407
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52282391
10* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50837768
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47389337
12* EED_16625203_ChIP-ChIP_MESCs_Mouse2.44567600
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.43759112
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41754742
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40026295
16* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37040973
17* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37040973
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.23962744
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23452296
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22121352
21* EZH2_27304074_Chip-Seq_ESCs_Mouse2.18569446
22* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18024736
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.93466511
24* P300_19829295_ChIP-Seq_ESCs_Human1.92477299
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91762346
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.89163190
27AR_21572438_ChIP-Seq_LNCaP_Human1.88439287
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87315678
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84856429
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84394883
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84354156
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84084160
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81543678
34SMAD4_21799915_ChIP-Seq_A2780_Human1.80076902
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79932233
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76325373
37DROSHA_22980978_ChIP-Seq_HELA_Human1.75358546
38* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.74632792
39CBP_20019798_ChIP-Seq_JUKART_Human1.74148418
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.74148418
41TAF15_26573619_Chip-Seq_HEK293_Human1.73772598
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71156487
43* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71035081
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.67195142
45TP53_18474530_ChIP-ChIP_U2OS_Human1.66701177
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66210264
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.62054551
48* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61694630
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59318777
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58933067
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58842868
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.55903986
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54864648
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51640088
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51062933
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50676705
57AR_25329375_ChIP-Seq_VCAP_Human1.48222872
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47359592
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.46336195
60FUS_26573619_Chip-Seq_HEK293_Human1.44221440
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43933552
62* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40261375
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39023082
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38410020
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36469367
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35778017
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.35082924
68IRF1_19129219_ChIP-ChIP_H3396_Human1.34764382
69RXR_22108803_ChIP-Seq_LS180_Human1.33123408
70* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33019548
71ER_23166858_ChIP-Seq_MCF-7_Human1.32126318
72* NANOG_18555785_Chip-Seq_ESCs_Mouse1.32119982
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30544839
74STAT3_23295773_ChIP-Seq_U87_Human1.29935365
75REST_21632747_ChIP-Seq_MESCs_Mouse1.28185211
76BCAT_22108803_ChIP-Seq_LS180_Human1.27829872
77* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26689532
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26532157
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26526973
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26465562
81TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.26396225
82TRIM28_21343339_ChIP-Seq_HEK293_Human1.24087701
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.22885954
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22159672
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.22003880
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21578867
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.21287399
88* RUNX2_22187159_ChIP-Seq_PCA_Human1.20836292
89TP53_22573176_ChIP-Seq_HFKS_Human1.20778039
90TP53_16413492_ChIP-PET_HCT116_Human1.20638529
91RNF2_27304074_Chip-Seq_NSC_Mouse1.19936462
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17716205
93TCF4_23295773_ChIP-Seq_U87_Human1.17567799
94VDR_22108803_ChIP-Seq_LS180_Human1.17326768
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.16650948
96P53_22387025_ChIP-Seq_ESCs_Mouse1.16617133
97IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15972959
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15749874
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15749874
100AHR_22903824_ChIP-Seq_MCF-7_Human1.15669475
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14976113
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.14950763
103TAL1_26923725_Chip-Seq_HPCs_Mouse1.14596284
104ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13555739
105EWS_26573619_Chip-Seq_HEK293_Human1.13051908
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11717689
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11261084
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08965641
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.07929234
110FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07884119
111NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07830202
112SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07369944
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06851321
114TCF4_18268006_ChIP-ChIP_LS174T_Human1.06814984
115CMYC_18555785_Chip-Seq_ESCs_Mouse1.06389168
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.06161337
117CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05636880
118* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05485859
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03574320
120SMAD3_21741376_ChIP-Seq_HESCs_Human1.02505225
121NCOR_22424771_ChIP-Seq_293T_Human1.02325569
122TCF4_22108803_ChIP-Seq_LS180_Human1.02068041
123EZH2_27294783_Chip-Seq_NPCs_Mouse1.01784830
124FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01598875
125P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01072206
126KDM2B_26808549_Chip-Seq_REH_Human1.00689195
127IGF1R_20145208_ChIP-Seq_DFB_Human0.99850322
128CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99845473
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99407529
130* JUN_21703547_ChIP-Seq_K562_Human0.98568501
131POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98299914
132FOXA1_25329375_ChIP-Seq_VCAP_Human0.97073100
133FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97073100
134FLI1_21867929_ChIP-Seq_TH2_Mouse0.95292350
135NANOG_19829295_ChIP-Seq_ESCs_Human0.94402839
136SOX2_19829295_ChIP-Seq_ESCs_Human0.94402839
137CDX2_22108803_ChIP-Seq_LS180_Human0.93723697
138SMAD4_21741376_ChIP-Seq_EPCs_Human0.91485642

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity5.13279007
2MP0002102_abnormal_ear_morphology4.15567941
3MP0008004_abnormal_stomach_pH3.35343418
4MP0005645_abnormal_hypothalamus_physiol3.02697079
5MP0004270_analgesia2.99325629
6MP0010386_abnormal_urinary_bladder2.93967169
7MP0000566_synostosis2.91293265
8MP0005503_abnormal_tendon_morphology2.83605658
9MP0002876_abnormal_thyroid_physiology2.76621976
10MP0004859_abnormal_synaptic_plasticity2.40695863
11MP0002822_catalepsy2.29861700
12MP0005367_renal/urinary_system_phenotyp2.22420078
13MP0000516_abnormal_urinary_system2.22420078
14MP0001968_abnormal_touch/_nociception2.04581474
15MP0004043_abnormal_pH_regulation2.04139052
16MP0005257_abnormal_intraocular_pressure1.99435794
17MP0002277_abnormal_respiratory_mucosa1.95305514
18MP0001188_hyperpigmentation1.95277978
19MP0001501_abnormal_sleep_pattern1.94571224
20MP0002735_abnormal_chemical_nociception1.93483149
21MP0002736_abnormal_nociception_after1.93388726
22MP0003635_abnormal_synaptic_transmissio1.90698973
23MP0004147_increased_porphyrin_level1.88401002
24MP0003941_abnormal_skin_development1.87639748
25MP0005394_taste/olfaction_phenotype1.87180861
26MP0005499_abnormal_olfactory_system1.87180861
27MP0009250_abnormal_appendicular_skeleto1.80802244
28MP0008877_abnormal_DNA_methylation1.78072401
29MP0009046_muscle_twitch1.76850415
30MP0008789_abnormal_olfactory_epithelium1.75392154
31MP0008995_early_reproductive_senescence1.75137961
32MP0003878_abnormal_ear_physiology1.74452163
33MP0005377_hearing/vestibular/ear_phenot1.74452163
34MP0008875_abnormal_xenobiotic_pharmacok1.74189420
35MP0001177_atelectasis1.71487917
36MP0009745_abnormal_behavioral_response1.69070289
37MP0003879_abnormal_hair_cell1.68175755
38MP0000013_abnormal_adipose_tissue1.67287265
39MP0002572_abnormal_emotion/affect_behav1.66138121
40MP0004142_abnormal_muscle_tone1.62498080
41MP0005551_abnormal_eye_electrophysiolog1.61079959
42MP0003938_abnormal_ear_development1.60268613
43MP0001664_abnormal_digestion1.59613715
44MP0000465_gastrointestinal_hemorrhage1.59538547
45MP0006276_abnormal_autonomic_nervous1.57357974
46MP0001486_abnormal_startle_reflex1.55988982
47MP0001346_abnormal_lacrimal_gland1.55675995
48MP0002734_abnormal_mechanical_nocicepti1.51444643
49MP0002063_abnormal_learning/memory/cond1.49159869
50MP0005646_abnormal_pituitary_gland1.47075851
51MP0002064_seizures1.46907702
52MP0002938_white_spotting1.46661320
53MP0003385_abnormal_body_wall1.45929247
54MP0002638_abnormal_pupillary_reflex1.45360905
55MP0000538_abnormal_urinary_bladder1.44912890
56MP0004272_abnormal_basement_membrane1.44662387
57MP0003880_abnormal_central_pattern1.43439852
58MP0002909_abnormal_adrenal_gland1.37202833
59MP0000631_abnormal_neuroendocrine_gland1.35406265
60MP0008438_abnormal_cutaneous_collagen1.35304787
61MP0005187_abnormal_penis_morphology1.34599508
62MP0000537_abnormal_urethra_morphology1.33741631
63MP0002234_abnormal_pharynx_morphology1.33534312
64MP0002751_abnormal_autonomic_nervous1.33304505
65MP0003122_maternal_imprinting1.30400303
66MP0001542_abnormal_bone_strength1.28848292
67MP0003221_abnormal_cardiomyocyte_apopto1.26331102
68MP0004484_altered_response_of1.25640117
69MP0001299_abnormal_eye_distance/1.24997105
70MP0003195_calcinosis1.24651823
71MP0002557_abnormal_social/conspecific_i1.24511032
72MP0001440_abnormal_grooming_behavior1.22860554
73MP0000427_abnormal_hair_cycle1.22032648
74MP0000762_abnormal_tongue_morphology1.21320537
75MP0004134_abnormal_chest_morphology1.21247524
76MP0004133_heterotaxia1.21172453
77MP0002184_abnormal_innervation1.20843060
78MP0002272_abnormal_nervous_system1.19939176
79MP0000678_abnormal_parathyroid_gland1.19052368
80MP0009697_abnormal_copulation1.18742764
81MP0005275_abnormal_skin_tensile1.18472190
82MP0005253_abnormal_eye_physiology1.17985066
83MP0001905_abnormal_dopamine_level1.17560518
84MP0001919_abnormal_reproductive_system1.17220217
85MP0004782_abnormal_surfactant_physiolog1.16966201
86MP0002108_abnormal_muscle_morphology1.15833298
87MP0005379_endocrine/exocrine_gland_phen1.13917066
88MP0009384_cardiac_valve_regurgitation1.13236955
89MP0003646_muscle_fatigue1.12485055
90MP0009780_abnormal_chondrocyte_physiolo1.11854592
91MP0005171_absent_coat_pigmentation1.11207385
92MP0003045_fibrosis1.10507841
93MP0002163_abnormal_gland_morphology1.09878805
94MP0002249_abnormal_larynx_morphology1.09592007
95MP0000681_abnormal_thyroid_gland1.09421450
96MP0001970_abnormal_pain_threshold1.09260280
97MP0004924_abnormal_behavior1.08811711
98MP0005386_behavior/neurological_phenoty1.08811711
99MP0001529_abnormal_vocalization1.08676157
100MP0000778_abnormal_nervous_system1.07699469
101MP0002998_abnormal_bone_remodeling1.07129443
102MP0002896_abnormal_bone_mineralization1.06940972
103MP0001984_abnormal_olfaction1.06807940
104MP0000163_abnormal_cartilage_morphology1.06459636
105MP0005508_abnormal_skeleton_morphology1.04129860
106MP0006292_abnormal_olfactory_placode1.04097658
107MP0002109_abnormal_limb_morphology1.03964240
108MP0003119_abnormal_digestive_system1.03800628
109MP0004811_abnormal_neuron_physiology1.03654695
110MP0000049_abnormal_middle_ear1.03637245
111MP0002069_abnormal_eating/drinking_beha1.02732207
112MP0002115_abnormal_skeleton_extremities1.02355115
113MP0002067_abnormal_sensory_capabilities0.99968202
114MP0000383_abnormal_hair_follicle0.99543548
115MP0002254_reproductive_system_inflammat0.99292828
116MP0002116_abnormal_craniofacial_bone0.99210964
117MP0008872_abnormal_physiological_respon0.99162317
118MP0002882_abnormal_neuron_morphology0.98907541
119MP0002752_abnormal_somatic_nervous0.97846526
120MP0003755_abnormal_palate_morphology0.96762244
121MP0005248_abnormal_Harderian_gland0.96702712
122MP0004858_abnormal_nervous_system0.95842238
123MP0003935_abnormal_craniofacial_develop0.93258635
124MP0005389_reproductive_system_phenotype0.91907387
125MP0000372_irregular_coat_pigmentation0.91235362
126MP0000955_abnormal_spinal_cord0.90579503
127MP0003137_abnormal_impulse_conducting0.90541336
128MP0003787_abnormal_imprinting0.89266612
129MP0001502_abnormal_circadian_rhythm0.89222866
130MP0002233_abnormal_nose_morphology0.88108354
131MP0001270_distended_abdomen0.87017147
132MP0002113_abnormal_skeleton_development0.86357893
133MP0004742_abnormal_vestibular_system0.85275571
134MP0002733_abnormal_thermal_nociception0.85126805
135MP0004885_abnormal_endolymph0.84472710
136MP0002098_abnormal_vibrissa_morphology0.83990324
137MP0005084_abnormal_gallbladder_morpholo0.83712251
138MP0004085_abnormal_heartbeat0.83567918
139MP0000534_abnormal_ureter_morphology0.83283886
140MP0000462_abnormal_digestive_system0.81371377
141MP0001963_abnormal_hearing_physiology0.79154665
142MP0000026_abnormal_inner_ear0.78877995
143MP0005423_abnormal_somatic_nervous0.78432581
144MP0005195_abnormal_posterior_eye0.78051491
145MP0002282_abnormal_trachea_morphology0.77829387
146MP0000569_abnormal_digit_pigmentation0.77541297
147MP0006072_abnormal_retinal_apoptosis0.76069345
148MP0002066_abnormal_motor_capabilities/c0.76053119
149MP0005083_abnormal_biliary_tract0.72990573
150MP0004215_abnormal_myocardial_fiber0.71591435
151MP0001293_anophthalmia0.70989661

Predicted human phenotypes

RankGene SetZ-score
1Follicular hyperkeratosis (HP:0007502)4.72378865
2Focal motor seizures (HP:0011153)4.31543051
3Midline defect of the nose (HP:0004122)4.25078831
4Cupped ear (HP:0000378)4.07735941
5Absent eyebrow (HP:0002223)4.06534577
6Thyroid-stimulating hormone excess (HP:0002925)3.91260251
7Pancreatic cysts (HP:0001737)3.85067969
8Abnormality of the parietal bone (HP:0002696)3.83178831
9Abnormality of incisor morphology (HP:0011063)3.68815498
10Amelogenesis imperfecta (HP:0000705)3.57829404
11Febrile seizures (HP:0002373)3.52748680
12Lissencephaly (HP:0001339)3.36628265
13Drooling (HP:0002307)3.22555395
14Medial flaring of the eyebrow (HP:0010747)3.17430799
15Split foot (HP:0001839)3.17187115
16Pancreatic fibrosis (HP:0100732)3.13326632
17True hermaphroditism (HP:0010459)3.06553859
18Hyperventilation (HP:0002883)3.05840607
19Epileptic encephalopathy (HP:0200134)3.03784792
20Excessive salivation (HP:0003781)2.95463611
21Aplasia/Hypoplasia of the brainstem (HP:0007362)2.95403981
22Hypoplasia of the brainstem (HP:0002365)2.95403981
23Alopecia of scalp (HP:0002293)2.94931646
24Nasolacrimal duct obstruction (HP:0000579)2.94557091
25Abnormality of the nasal septum (HP:0000419)2.93710926
26Gait imbalance (HP:0002141)2.88568538
27Abnormal respiratory motile cilium morphology (HP:0005938)2.87937439
28Abnormal respiratory epithelium morphology (HP:0012253)2.87937439
29Occipital encephalocele (HP:0002085)2.87767113
30Abnormality of the lacrimal duct (HP:0011481)2.87136599
31Pachygyria (HP:0001302)2.85302551
32Cortical dysplasia (HP:0002539)2.85114221
33Absent eyelashes (HP:0000561)2.85027132
34Abnormality of midbrain morphology (HP:0002418)2.81876100
35Molar tooth sign on MRI (HP:0002419)2.81876100
36Vitreoretinal degeneration (HP:0000655)2.81053628
37Unilateral renal agenesis (HP:0000122)2.80680406
38Nephrogenic diabetes insipidus (HP:0009806)2.78744411
39Type II lissencephaly (HP:0007260)2.77997043
40Retinal dysplasia (HP:0007973)2.76476321
41Congenital primary aphakia (HP:0007707)2.76280067
42Genital tract atresia (HP:0001827)2.76149565
43Pendular nystagmus (HP:0012043)2.75011106
44Vaginal atresia (HP:0000148)2.73994658
45Nephronophthisis (HP:0000090)2.72930941
46Conical tooth (HP:0000698)2.71344124
47Parakeratosis (HP:0001036)2.70123096
48Abnormality of the nasolacrimal system (HP:0000614)2.69856352
49Abnormality of the ischium (HP:0003174)2.59408278
50Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.58567458
51Short 4th metacarpal (HP:0010044)2.58567458
52Atrophic scars (HP:0001075)2.58143253
53Aplasia cutis congenita (HP:0001057)2.57635267
54Abnormality of the renal medulla (HP:0100957)2.43668169
55Recurrent corneal erosions (HP:0000495)2.42140691
56Absent speech (HP:0001344)2.38784417
57Milia (HP:0001056)2.37914413
58Absent/shortened dynein arms (HP:0200106)2.35207900
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.35207900
60White forelock (HP:0002211)2.33262746
61Cystic liver disease (HP:0006706)2.30275498
62Abnormality of the renal cortex (HP:0011035)2.28364828
63Ankle clonus (HP:0011448)2.28271800
64Aplasia/hypoplasia of the uterus (HP:0008684)2.25507877
65Flat capital femoral epiphysis (HP:0003370)2.25442431
66Decreased circulating renin level (HP:0003351)2.25212188
67Cutaneous finger syndactyly (HP:0010554)2.24878412
68Progressive inability to walk (HP:0002505)2.24449250
69Morphological abnormality of the middle ear (HP:0008609)2.22278749
70Shawl scrotum (HP:0000049)2.22133099
71Hyperphosphatemia (HP:0002905)2.21716248
72Hypsarrhythmia (HP:0002521)2.21675049
73Specific learning disability (HP:0001328)2.19633715
74Patellar aplasia (HP:0006443)2.17778396
75Submucous cleft hard palate (HP:0000176)2.17713391
76Hypoplastic ischia (HP:0003175)2.17136112
77Neonatal respiratory distress (HP:0002643)2.17101891
78Renal cortical cysts (HP:0000803)2.16338552
79Congenital sensorineural hearing impairment (HP:0008527)2.16049928
80Bell-shaped thorax (HP:0001591)2.14761914
81Patchy hypopigmentation of hair (HP:0011365)2.14207364
82Polymicrogyria (HP:0002126)2.13689387
83Abnormality of calcium-phosphate metabolism (HP:0100530)2.13245947
84Focal seizures (HP:0007359)2.12673237
85Abnormal respiratory motile cilium physiology (HP:0012261)2.11202179
86Abnormality of the incisor (HP:0000676)2.10135870
87Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.09220102
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08976475
89Abnormality of dental color (HP:0011073)2.08646564
90Urinary urgency (HP:0000012)2.08530352
91EEG with generalized epileptiform discharges (HP:0011198)2.08332850
92Blue irides (HP:0000635)2.07190369
93Narrow nasal bridge (HP:0000446)2.07068833
94Hypothermia (HP:0002045)2.06612052
95Atonic seizures (HP:0010819)2.06163207
96Hyperactive renin-angiotensin system (HP:0000841)2.06113002
97Tubulointerstitial fibrosis (HP:0005576)2.05934128
98Broad metatarsal (HP:0001783)2.03885149
99Keratoconus (HP:0000563)2.03752338
100Increased corneal curvature (HP:0100692)2.03752338
101Accelerated skeletal maturation (HP:0005616)2.03721920
102Prominent supraorbital ridges (HP:0000336)2.02386589
103Aplasia/Hypoplasia of the patella (HP:0006498)2.02224869
104Absent frontal sinuses (HP:0002688)2.01941070
105Esotropia (HP:0000565)2.01312812
106Abnormal hair whorl (HP:0010721)2.01208721
107Hemiparesis (HP:0001269)2.00930633
108Agitation (HP:0000713)2.00902789
109Cerebellar dysplasia (HP:0007033)2.00774462
110Cerebral palsy (HP:0100021)1.99994335
111Epileptiform EEG discharges (HP:0011182)1.99060329
112Tubulointerstitial abnormality (HP:0001969)1.97973708
113Shoulder girdle muscle weakness (HP:0003547)1.96679376
114Osteomalacia (HP:0002749)1.94939058
115Limb dystonia (HP:0002451)1.94691986
116Aortic dissection (HP:0002647)1.94478702
117Dyskinesia (HP:0100660)1.93957681
118Abnormality of the vitamin B12 metabolism (HP:0004341)1.93669016
119Intellectual disability, severe (HP:0010864)1.92651450
120Omphalocele (HP:0001539)1.92475600
121Trigonocephaly (HP:0000243)1.92147285
122Anterior segment dysgenesis (HP:0007700)1.91728146
123Aplasia/Hypoplasia of the tibia (HP:0005772)1.90354946
124Mesomelia (HP:0003027)1.89953126
125Hypoplasia of the corpus callosum (HP:0002079)1.89177872
126Severe muscular hypotonia (HP:0006829)1.87951614
127Tubulointerstitial nephritis (HP:0001970)1.87626197
128Abnormality of the labia minora (HP:0012880)1.87158927
129Rhinitis (HP:0012384)1.86649095
130Abnormality of the musculature of the pelvis (HP:0001469)1.86427876
131Abnormality of the hip-girdle musculature (HP:0001445)1.86427876
132Increased number of teeth (HP:0011069)1.86425063
133Abnormality of the right ventricle (HP:0001707)1.85892560
134Aplasia involving bones of the upper limbs (HP:0009823)1.85691812
135Aplasia of the phalanges of the hand (HP:0009802)1.85691812
136Aplasia involving bones of the extremities (HP:0009825)1.85691812
137Postaxial hand polydactyly (HP:0001162)1.83883348
138Hypoventilation (HP:0002791)1.83798130
139Cutaneous syndactyly (HP:0012725)1.82068140
140Progressive cerebellar ataxia (HP:0002073)1.81073228
141Intellectual disability, moderate (HP:0002342)1.81047367
142Congenital stationary night blindness (HP:0007642)1.80266718
143Chronic hepatic failure (HP:0100626)1.78932110
144Abnormality of vitamin B metabolism (HP:0004340)1.78800908
145Onycholysis (HP:0001806)1.78364108
146Tubular atrophy (HP:0000092)1.78328528
147Bile duct proliferation (HP:0001408)1.78213977
148Abnormal biliary tract physiology (HP:0012439)1.78213977
149Large earlobe (HP:0009748)1.77957113
150Small epiphyses (HP:0010585)1.77516739
151Abnormality of proline metabolism (HP:0010907)1.76899574
152Hydroxyprolinuria (HP:0003080)1.76899574
153Spastic tetraplegia (HP:0002510)1.75866047
154Cheilitis (HP:0100825)1.75763773
155Abolished electroretinogram (ERG) (HP:0000550)1.75642826
156Polyphagia (HP:0002591)1.75331261
157Abnormality of salivation (HP:0100755)1.75326489
158Thickened helices (HP:0000391)1.74852765
159Protruding tongue (HP:0010808)1.74005792
160Bilateral sensorineural hearing impairment (HP:0008619)1.72909598
161Broad-based gait (HP:0002136)1.72660375
162Hypoplasia of dental enamel (HP:0006297)1.71754994
163Abnormality of the pubic bones (HP:0003172)1.70391045
164Abnormality of the 4th metacarpal (HP:0010012)1.69825165
165Generalized tonic-clonic seizures (HP:0002069)1.69574983
166Abnormality of the distal phalanx of the thumb (HP:0009617)1.67023671
167Absent hair (HP:0002298)1.66936072
168Alveolar cell carcinoma (HP:0006519)1.66511122
169Prostate neoplasm (HP:0100787)1.65711685
170Epiphyseal dysplasia (HP:0002656)1.65698055
171Shallow orbits (HP:0000586)1.64767250
172Microglossia (HP:0000171)1.64727268
173Slender build (HP:0001533)1.64578408
174Limited hip movement (HP:0008800)1.64150348
175Widely spaced teeth (HP:0000687)1.63699936
176Aqueductal stenosis (HP:0002410)1.63513403
177Anophthalmia (HP:0000528)1.63224184
178Neonatal short-limb short stature (HP:0008921)1.63000445
179Coronal craniosynostosis (HP:0004440)1.62495548
180Short tibia (HP:0005736)1.62484352
181Short palm (HP:0004279)1.61683218
182Abnormality of the phalanges of the 2nd finger (HP:0009541)1.58846687
183Inability to walk (HP:0002540)1.58490658
184Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57009345
185Abnormal ciliary motility (HP:0012262)1.56058924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.80527062
2CASK3.99780828
3TRIM283.90969890
4MAP2K73.33267418
5MAP4K23.06406967
6MAP3K123.05985087
7AKT32.78155365
8FGFR22.56860040
9MAP3K42.51360393
10PRPF4B2.36225123
11NTRK32.21499165
12SIK22.07178681
13SIK12.06357928
14EPHA32.03557819
15FRK2.01111627
16DYRK22.00760025
17PLK21.88565361
18CSNK1G31.88168734
19CSNK1A1L1.81334792
20DDR21.77993435
21MAP2K41.76590015
22SRPK11.75598370
23MYLK1.74200055
24CSNK1G21.72866828
25CSNK1G11.70192421
26CDK81.70026019
27DAPK21.67917526
28PINK11.65810874
29GRK71.65455578
30EPHA41.59302973
31SGK21.55629599
32LATS11.48954842
33RIPK41.45685945
34MAPK131.42810807
35EPHB21.39821963
36INSRR1.38868870
37BMPR21.38767148
38GRK11.22692051
39ADRBK21.13140561
40YES11.13101446
41STK38L1.12869947
42BCKDK1.10130094
43CAMKK21.10076549
44CAMK11.09931887
45BMPR1B1.06704013
46NTRK21.06661978
47PIK3CA1.04898119
48PRKCE1.04236680
49RPS6KA41.02986355
50TNIK1.02405132
51ZAK0.98856904
52EIF2AK20.97918102
53PAK30.96168486
54PTK2B0.95452102
55SGK2230.95381749
56SGK4940.95381749
57CDK190.94323491
58GRK50.93178237
59FER0.92642590
60CAMK1G0.90895374
61SGK30.88972497
62MARK10.86785150
63FGFR30.85470924
64CCNB10.85165945
65MINK10.82880844
66TAOK30.82082174
67DYRK1A0.81263128
68NME10.79328608
69BCR0.78434044
70NUAK10.78346801
71CAMK40.78124124
72STK390.77824337
73ERBB30.71842415
74CDK30.71797836
75DYRK1B0.71773591
76TAOK20.71750541
77LATS20.71566171
78DAPK10.70995471
79MAPK150.70921812
80GRK60.70851527
81MAP3K60.70722381
82DMPK0.69124037
83ACVR1B0.68305765
84CAMK2A0.68038491
85PRKCZ0.66905677
86SGK10.65565960
87LMTK20.64768501
88MST1R0.64313424
89MAP3K140.64119953
90STK380.62110772
91CAMK2B0.60778247
92OXSR10.59998025
93ADRBK10.58390827
94CDK50.57984283
95DYRK30.55440892
96RPS6KA50.51124253
97CSNK1D0.50650705
98LIMK10.49434541
99CAMK1D0.48886866
100KSR10.48154864
101MAPK70.47422840
102PRKCG0.47235130
103TNK20.46401155
104PDGFRA0.44384629
105TGFBR20.44372025
106MARK20.44072780
107MAPKAPK30.43926976
108WNK30.42566757
109MAP2K10.42185266
110TIE10.42053148
111VRK10.40984903
112PRKAA10.39883658
113FGR0.37259690
114MST40.36785052
115WNK40.36100226
116PIK3CG0.35774480
117TXK0.33646957
118MAPK90.33643683
119PRKG10.33301073
120PRKCH0.32992483
121CAMK2G0.32557628
122MAP3K50.32483530
123CHUK0.32185308
124MARK30.32108913
125PRKACB0.32052859
126PDGFRB0.31480957
127EPHB10.29385730
128ABL10.29316587
129RIPK10.28989519
130UHMK10.28572850
131MAPKAPK50.28294300
132PRKCA0.27573650
133PLK30.27048417
134ERBB40.27012591
135CSNK1A10.26687142
136IGF1R0.26675916
137PRKD30.26407464
138CDK90.26295255
139PRKACA0.25786093
140PRKAA20.25337133
141MAPK120.24653684
142TGFBR10.24171017
143FGFR10.23645451
144PRKACG0.23346169
145MAP3K130.22201287
146PIM20.22115323

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.12183593
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.93593864
3Butanoate metabolism_Homo sapiens_hsa006502.59826430
4Caffeine metabolism_Homo sapiens_hsa002322.55630681
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.54763605
6Synaptic vesicle cycle_Homo sapiens_hsa047212.46708030
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35071169
8Linoleic acid metabolism_Homo sapiens_hsa005912.24941845
9Morphine addiction_Homo sapiens_hsa050322.21672631
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.17874584
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04293363
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04175034
13Circadian entrainment_Homo sapiens_hsa047131.98736750
14GABAergic synapse_Homo sapiens_hsa047271.97186568
15Olfactory transduction_Homo sapiens_hsa047401.97161384
16Renin secretion_Homo sapiens_hsa049241.90849011
17Taste transduction_Homo sapiens_hsa047421.85406692
18Collecting duct acid secretion_Homo sapiens_hsa049661.84094788
19Salivary secretion_Homo sapiens_hsa049701.75955697
20Ether lipid metabolism_Homo sapiens_hsa005651.75352777
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.74334008
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72137772
23Calcium signaling pathway_Homo sapiens_hsa040201.70400203
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64773059
25Serotonergic synapse_Homo sapiens_hsa047261.63122340
26ECM-receptor interaction_Homo sapiens_hsa045121.59924580
27Protein digestion and absorption_Homo sapiens_hsa049741.59199702
28Glutamatergic synapse_Homo sapiens_hsa047241.55012398
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.53426946
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.49312392
31Amphetamine addiction_Homo sapiens_hsa050311.43648247
32Axon guidance_Homo sapiens_hsa043601.42231297
33Insulin secretion_Homo sapiens_hsa049111.39811928
34Long-term depression_Homo sapiens_hsa047301.38882973
35Regulation of autophagy_Homo sapiens_hsa041401.37173909
36Long-term potentiation_Homo sapiens_hsa047201.36852342
37Vibrio cholerae infection_Homo sapiens_hsa051101.36794973
38Cholinergic synapse_Homo sapiens_hsa047251.35702573
39Selenocompound metabolism_Homo sapiens_hsa004501.34266842
40Nitrogen metabolism_Homo sapiens_hsa009101.30606172
41Gastric acid secretion_Homo sapiens_hsa049711.28974390
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28063731
43Dopaminergic synapse_Homo sapiens_hsa047281.26563004
44cAMP signaling pathway_Homo sapiens_hsa040241.26419726
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21829859
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.21463366
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20659548
48Chemical carcinogenesis_Homo sapiens_hsa052041.19407554
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19264087
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18090092
51Pancreatic secretion_Homo sapiens_hsa049721.17658587
52Histidine metabolism_Homo sapiens_hsa003401.14573361
53Basal cell carcinoma_Homo sapiens_hsa052171.12876937
54ABC transporters_Homo sapiens_hsa020101.12285005
55Melanoma_Homo sapiens_hsa052181.11769321
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11226363
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10776616
58Type II diabetes mellitus_Homo sapiens_hsa049301.10542383
59Oxytocin signaling pathway_Homo sapiens_hsa049211.08213207
60Wnt signaling pathway_Homo sapiens_hsa043101.08126796
61Fat digestion and absorption_Homo sapiens_hsa049751.08026184
62Rheumatoid arthritis_Homo sapiens_hsa053231.05369235
63cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04795033
64Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04624102
65beta-Alanine metabolism_Homo sapiens_hsa004101.03642501
66Type I diabetes mellitus_Homo sapiens_hsa049401.02350482
67Sulfur metabolism_Homo sapiens_hsa009201.02183149
68Maturity onset diabetes of the young_Homo sapiens_hsa049501.01686348
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00935637
70Mineral absorption_Homo sapiens_hsa049781.00308858
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.99064296
72Peroxisome_Homo sapiens_hsa041460.98480828
73Basal transcription factors_Homo sapiens_hsa030220.97376952
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97173822
75ErbB signaling pathway_Homo sapiens_hsa040120.95858483
76African trypanosomiasis_Homo sapiens_hsa051430.95718304
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95051530
78Phototransduction_Homo sapiens_hsa047440.94745916
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94176283
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92192492
81Retinol metabolism_Homo sapiens_hsa008300.90132185
82Cocaine addiction_Homo sapiens_hsa050300.89088069
83Hedgehog signaling pathway_Homo sapiens_hsa043400.89070566
84Phagosome_Homo sapiens_hsa041450.88648395
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88540831
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87368315
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86697872
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85897643
89Melanogenesis_Homo sapiens_hsa049160.85732667
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83568299
91Oxidative phosphorylation_Homo sapiens_hsa001900.82736417
92Ras signaling pathway_Homo sapiens_hsa040140.79549352
93GnRH signaling pathway_Homo sapiens_hsa049120.79137395
94Arachidonic acid metabolism_Homo sapiens_hsa005900.78512182
95Propanoate metabolism_Homo sapiens_hsa006400.77314144
96Starch and sucrose metabolism_Homo sapiens_hsa005000.77133777
97Tryptophan metabolism_Homo sapiens_hsa003800.76844374
98Focal adhesion_Homo sapiens_hsa045100.76626158
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73796632
100Gap junction_Homo sapiens_hsa045400.73696037
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73109444
102Dilated cardiomyopathy_Homo sapiens_hsa054140.72718082
103Ovarian steroidogenesis_Homo sapiens_hsa049130.72678182
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71746079
105Vitamin digestion and absorption_Homo sapiens_hsa049770.69621783
106Rap1 signaling pathway_Homo sapiens_hsa040150.69320623
107RNA degradation_Homo sapiens_hsa030180.68762974
108Glioma_Homo sapiens_hsa052140.68143456
109Protein export_Homo sapiens_hsa030600.67161879
110Adherens junction_Homo sapiens_hsa045200.65447009
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63236730
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.61521641
113MAPK signaling pathway_Homo sapiens_hsa040100.61416423
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61220763
115Estrogen signaling pathway_Homo sapiens_hsa049150.58905978
116Huntingtons disease_Homo sapiens_hsa050160.58836433
117Parkinsons disease_Homo sapiens_hsa050120.58771730
118Fanconi anemia pathway_Homo sapiens_hsa034600.58396423
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56590041
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56007114
121Amoebiasis_Homo sapiens_hsa051460.55112095
122Inositol phosphate metabolism_Homo sapiens_hsa005620.54995491
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53927341
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53738303
125Steroid biosynthesis_Homo sapiens_hsa001000.53119019
126Choline metabolism in cancer_Homo sapiens_hsa052310.51993641
127Hippo signaling pathway_Homo sapiens_hsa043900.50592850
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49571238
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48514787
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47787929
131Fatty acid elongation_Homo sapiens_hsa000620.47761759
132Pathways in cancer_Homo sapiens_hsa052000.47515491
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46140973
134TNF signaling pathway_Homo sapiens_hsa046680.45996247
135Colorectal cancer_Homo sapiens_hsa052100.45940261
136Endometrial cancer_Homo sapiens_hsa052130.45914806
137Renin-angiotensin system_Homo sapiens_hsa046140.44815706
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44588973
139Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43424485
140Thyroid hormone synthesis_Homo sapiens_hsa049180.42887118
141TGF-beta signaling pathway_Homo sapiens_hsa043500.42496382
142Metabolic pathways_Homo sapiens_hsa011000.42197810
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41770553
144Tuberculosis_Homo sapiens_hsa051520.40887699
145Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40601227
146Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40468847
147Circadian rhythm_Homo sapiens_hsa047100.39841761
148Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39647553
149Autoimmune thyroid disease_Homo sapiens_hsa053200.39385075
150Toxoplasmosis_Homo sapiens_hsa051450.38359111
151Sphingolipid metabolism_Homo sapiens_hsa006000.37826719
152Fatty acid biosynthesis_Homo sapiens_hsa000610.37742656
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37110920
154Phenylalanine metabolism_Homo sapiens_hsa003600.34962624
155Prostate cancer_Homo sapiens_hsa052150.34740551
156Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34176152
157Pancreatic cancer_Homo sapiens_hsa052120.33911917
158Bile secretion_Homo sapiens_hsa049760.33526628
159RNA polymerase_Homo sapiens_hsa030200.30762903
160Glycerolipid metabolism_Homo sapiens_hsa005610.30409171
161Cardiac muscle contraction_Homo sapiens_hsa042600.28659927
162Glycerophospholipid metabolism_Homo sapiens_hsa005640.27780663

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