BMP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bone trabecula formation (GO:0060346)6.04217260
2lateral sprouting from an epithelium (GO:0060601)4.99391041
3protein maturation by protein folding (GO:0022417)4.96857445
4mesenchymal-epithelial cell signaling (GO:0060638)4.88974678
5regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.80030205
6Golgi transport vesicle coating (GO:0048200)4.70012164
7COPI coating of Golgi vesicle (GO:0048205)4.70012164
8dermatan sulfate biosynthetic process (GO:0030208)4.67838898
9paraxial mesoderm development (GO:0048339)4.57151417
10* regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.47958927
11* mesenchymal cell proliferation (GO:0010463)4.45596633
12cell proliferation involved in metanephros development (GO:0072203)4.26017862
13dermatan sulfate metabolic process (GO:0030205)4.24178113
14planar cell polarity pathway involved in neural tube closure (GO:0090179)4.15350246
15* craniofacial suture morphogenesis (GO:0097094)4.14438038
16establishment of integrated proviral latency (GO:0075713)4.10983081
17protein retention in ER lumen (GO:0006621)3.96630166
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.95857857
19regulation of metalloenzyme activity (GO:0048552)3.91394155
20proline biosynthetic process (GO:0006561)3.84185848
21regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.83678988
22* cell proliferation involved in kidney development (GO:0072111)3.83434761
23desmosome organization (GO:0002934)3.79521465
24chondrocyte proliferation (GO:0035988)3.78649941
25polarized epithelial cell differentiation (GO:0030859)3.72821623
26* cranial suture morphogenesis (GO:0060363)3.71683931
27regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.65118949
28branching involved in salivary gland morphogenesis (GO:0060445)3.62141254
29establishment of viral latency (GO:0019043)3.52781854
30collagen fibril organization (GO:0030199)3.47662385
31extracellular fibril organization (GO:0043206)3.47320111
32epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.47137692
33protein heterotrimerization (GO:0070208)3.44178711
34bundle of His cell to Purkinje myocyte communication (GO:0086069)3.41445145
35hippo signaling (GO:0035329)3.41357957
36muscle cell migration (GO:0014812)3.41324742
37anterior/posterior axis specification, embryo (GO:0008595)3.40836271
38sequestering of extracellular ligand from receptor (GO:0035581)3.40617775
39ventricular cardiac muscle cell development (GO:0055015)3.40368288
40lung vasculature development (GO:0060426)3.38427477
41prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.31767494
42galactose catabolic process (GO:0019388)3.30102283
43surfactant homeostasis (GO:0043129)3.29530256
44skin morphogenesis (GO:0043589)3.27656515
45cell migration involved in heart development (GO:0060973)3.26827385
46establishment of apical/basal cell polarity (GO:0035089)3.25953237
47wound healing, spreading of epidermal cells (GO:0035313)3.22761229
48kidney mesenchyme development (GO:0072074)3.20569478
49protein localization to cell surface (GO:0034394)3.20232693
50lung-associated mesenchyme development (GO:0060484)3.19306810
51regulation of non-canonical Wnt signaling pathway (GO:2000050)3.17841562
52branching involved in mammary gland duct morphogenesis (GO:0060444)3.17819184
53* mesenchyme development (GO:0060485)3.15060294
54glomerular basement membrane development (GO:0032836)3.14107463
55metanephric mesenchyme development (GO:0072075)3.10802632
56peptidyl-glutamic acid carboxylation (GO:0017187)3.10326294
57protein carboxylation (GO:0018214)3.10326294
58blood vessel maturation (GO:0001955)3.10177879
59positive regulation of catenin import into nucleus (GO:0035413)3.09203190
60regulation of sister chromatid cohesion (GO:0007063)3.08608508
61proline metabolic process (GO:0006560)3.07889860
62peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.07465210
63* embryonic cranial skeleton morphogenesis (GO:0048701)3.05123229
64radial glial cell differentiation (GO:0060019)3.04734972
65cardiac epithelial to mesenchymal transition (GO:0060317)3.03177969
66positive regulation of actin filament depolymerization (GO:0030836)3.02073595
67* regulation of SMAD protein import into nucleus (GO:0060390)3.01769104
68outflow tract septum morphogenesis (GO:0003148)3.01284060
69* organ induction (GO:0001759)3.00318628
70fibrinolysis (GO:0042730)3.00281290
71bone remodeling (GO:0046849)2.99764849
72dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.99197697
73* axis elongation (GO:0003401)2.98789482
74G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.97486014
75negative regulation of catenin import into nucleus (GO:0035414)2.97418568
76regulation of gene silencing by RNA (GO:0060966)2.97226774
77regulation of posttranscriptional gene silencing (GO:0060147)2.97226774
78regulation of gene silencing by miRNA (GO:0060964)2.97226774
79regulation of catenin import into nucleus (GO:0035412)2.96950130
80positive regulation of mesenchymal cell proliferation (GO:0002053)2.96776144
81* cell surface receptor signaling pathway involved in heart development (GO:0061311)2.96565184
82notochord development (GO:0030903)2.94065284
83* positive regulation of SMAD protein import into nucleus (GO:0060391)2.92978684
84negative regulation of fibrinolysis (GO:0051918)2.92442415
85regulation of cell fate specification (GO:0042659)2.92154290
86basement membrane organization (GO:0071711)2.90494174
87convergent extension (GO:0060026)2.89389396
88very-low-density lipoprotein particle assembly (GO:0034379)2.89336679
89barbed-end actin filament capping (GO:0051016)2.88571879
90negative regulation of cell fate specification (GO:0009996)2.88055184
91* branch elongation of an epithelium (GO:0060602)2.87283545
92axon extension involved in axon guidance (GO:0048846)2.87164022
93neuron projection extension involved in neuron projection guidance (GO:1902284)2.87164022
94* negative regulation of chondrocyte differentiation (GO:0032331)2.87150155
95trabecula formation (GO:0060343)2.86707867
96digestive tract morphogenesis (GO:0048546)2.86589664
97mesenchyme morphogenesis (GO:0072132)2.85614269
98myelination in peripheral nervous system (GO:0022011)2.84335705
99peripheral nervous system axon ensheathment (GO:0032292)2.84335705
100positive regulation of pseudopodium assembly (GO:0031274)2.83830272
101outer ear morphogenesis (GO:0042473)2.81812402
102* respiratory tube development (GO:0030323)2.80822643
103regulation of hippo signaling (GO:0035330)2.80562750
104* mesonephros development (GO:0001823)2.80084000
105cellular response to vitamin D (GO:0071305)2.79828134
106* regulation of morphogenesis of a branching structure (GO:0060688)2.79566404
107fibril organization (GO:0097435)2.79421314
108retina vasculature morphogenesis in camera-type eye (GO:0061299)2.79355128
109regulation of cardioblast differentiation (GO:0051890)2.79339234
110* regulation of mesenchymal cell proliferation (GO:0010464)2.77687535
111* negative regulation of embryonic development (GO:0045992)2.77687062
112regulation of keratinocyte proliferation (GO:0010837)2.75019722
113regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.74759991
114* negative regulation of stem cell proliferation (GO:2000647)2.74637809
115negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.73102570
116L-phenylalanine metabolic process (GO:0006558)2.73006160
117erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.73006160
118* embryonic skeletal joint morphogenesis (GO:0060272)2.72980641
119lymphangiogenesis (GO:0001946)2.72490576
120* hindlimb morphogenesis (GO:0035137)2.72258440
121lung epithelium development (GO:0060428)2.71717198
122heterochromatin organization (GO:0070828)2.71472091
123* endocardial cushion development (GO:0003197)2.70407911
124negative regulation of axon extension involved in axon guidance (GO:0048843)2.70157256
125ribosome assembly (GO:0042255)2.69592300
126Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.69254671
127establishment of monopolar cell polarity (GO:0061162)2.69097008
128establishment or maintenance of monopolar cell polarity (GO:0061339)2.69097008
129negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.68723256
130glomerular filtration (GO:0003094)2.68545659
131mitotic nuclear envelope reassembly (GO:0007084)2.67652611
132nuclear envelope reassembly (GO:0031468)2.67652611
133dorsal/ventral axis specification (GO:0009950)2.66999701
134embryonic camera-type eye development (GO:0031076)2.66902974
135endothelial cell morphogenesis (GO:0001886)2.66785756
136embryonic digestive tract morphogenesis (GO:0048557)2.66512642
137regulation of transforming growth factor beta2 production (GO:0032909)2.66415158
138nucleotide-sugar biosynthetic process (GO:0009226)2.66259605
139otic vesicle formation (GO:0030916)2.66174279
140virion attachment to host cell (GO:0019062)2.66033358
141adhesion of symbiont to host cell (GO:0044650)2.66033358
142chemical homeostasis within a tissue (GO:0048875)2.65329727
143* mesonephric tubule development (GO:0072164)2.63549548
144embryonic foregut morphogenesis (GO:0048617)2.61792303
145regulation of cholesterol homeostasis (GO:2000188)2.58024592
146galactose metabolic process (GO:0006012)2.54457637
1474-hydroxyproline metabolic process (GO:0019471)2.50815415
148regulation of extracellular matrix disassembly (GO:0010715)2.50037832
149regulation of plasminogen activation (GO:0010755)2.48351432
150negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.47727661
151regulation of pseudopodium assembly (GO:0031272)2.47503330
152mitotic chromosome condensation (GO:0007076)2.47470925
153protein hydroxylation (GO:0018126)2.46245168
154actin filament depolymerization (GO:0030042)2.46239843
155receptor catabolic process (GO:0032801)2.45952520
156regulation of mammary gland epithelial cell proliferation (GO:0033599)2.45187040
157proteasome assembly (GO:0043248)2.45051221
158pinocytosis (GO:0006907)2.44165858
159positive regulation of epithelial to mesenchymal transition (GO:0010718)2.44039646
160GDP-mannose metabolic process (GO:0019673)2.42744077
161positive regulation of osteoblast proliferation (GO:0033690)2.42373858
162hepatocyte differentiation (GO:0070365)2.40761150
163retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.40244771
164COPII vesicle coating (GO:0048208)2.40108136
165DNA unwinding involved in DNA replication (GO:0006268)2.39670575
166regulation of fibrinolysis (GO:0051917)2.39274483
167regulation of glomerular filtration (GO:0003093)2.38826563
168regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.38221293
169renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.37591056
170regulation of mitotic spindle organization (GO:0060236)2.37306705
171cellular copper ion homeostasis (GO:0006878)2.36131260
172gap junction assembly (GO:0016264)2.35628743
173peptidyl-proline hydroxylation (GO:0019511)2.34759469
174membrane raft organization (GO:0031579)2.32505293
175regulation of bile acid biosynthetic process (GO:0070857)2.32369798
176plasma lipoprotein particle assembly (GO:0034377)2.30902469
177negative regulation of coagulation (GO:0050819)2.30083270
178apoptotic cell clearance (GO:0043277)2.29509778
179SMAD protein complex assembly (GO:0007183)2.29103599
180trophoblast giant cell differentiation (GO:0060707)2.28779597
181glucose catabolic process (GO:0006007)2.28023939
182mesoderm formation (GO:0001707)2.26312789
183intestinal cholesterol absorption (GO:0030299)2.25851009
184regulation of protein activation cascade (GO:2000257)2.25812594
185regulation of complement activation (GO:0030449)2.24674571
186regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.24232184
187type B pancreatic cell proliferation (GO:0044342)2.20237361

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.92601517
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.71497183
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.56657464
4* KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.36657161
5* KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.36657161
6* KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.36657161
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.08717112
8ZNF263_19887448_ChIP-Seq_K562_Human2.95404263
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.88639770
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.76071761
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66099045
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64194995
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.62689381
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.60220501
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55690355
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.49525823
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.43047821
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.39819291
19TCF3_18692474_ChIP-Seq_MEFs_Mouse2.36008876
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.35533485
21CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.33111655
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.31998092
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.29431603
24ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.28252830
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.22702018
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.21629772
27* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.16281771
28* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.14222469
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.11984541
30SALL1_21062744_ChIP-ChIP_HESCs_Human2.11481369
31EP300_21415370_ChIP-Seq_HL-1_Mouse2.11437582
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.09383562
33POU5F1_16153702_ChIP-ChIP_HESCs_Human2.07668880
34* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.05747335
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99388448
36* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.99002256
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.98549976
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97125141
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96188316
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.92312198
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90975435
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.89059966
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.84664016
44* EED_16625203_ChIP-ChIP_MESCs_Mouse1.80373267
45TCF3_18692474_ChIP-Seq_MESCs_Mouse1.78850240
46* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.78809295
47* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78483947
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76623016
49* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.75964634
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74708354
51* ELK3_25401928_ChIP-Seq_HUVEC_Human1.74330471
52CJUN_26792858_Chip-Seq_BT549_Human1.74246860
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.73937714
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.73006252
55ATF3_27146783_Chip-Seq_COLON_Human1.71434073
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.70564883
57* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.69809256
58* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69598279
59* ISL1_27105846_Chip-Seq_CPCs_Mouse1.68069572
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.68033848
61SALL4_18804426_ChIP-ChIP_XEN_Mouse1.66198811
62CDX2_20551321_ChIP-Seq_CACO-2_Human1.63682931
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.63361083
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.63226102
65* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.58724760
66* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.57331175
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55458023
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55223795
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.54965437
70* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.54273043
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.54117110
72* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.53110191
73BRD4_25478319_ChIP-Seq_HGPS_Human1.51664236
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.50112223
75SOX17_20123909_ChIP-Seq_XEN_Mouse1.49649141
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47947609
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46734027
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46300647
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45698581
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45012102
81* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43689893
82ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.43288341
83RACK7_27058665_Chip-Seq_MCF-7_Human1.43271180
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42492847
85DCP1A_22483619_ChIP-Seq_HELA_Human1.41958370
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.41502890
87NANOG_16153702_ChIP-ChIP_HESCs_Human1.41322765
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40632870
89CLOCK_20551151_ChIP-Seq_293T_Human1.38732510
90* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38660930
91PPARA_22158963_ChIP-Seq_LIVER_Mouse1.37725813
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37723653
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37486455
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36150813
95BP1_19119308_ChIP-ChIP_Hs578T_Human1.35789418
96AR_21909140_ChIP-Seq_LNCAP_Human1.35248715
97* SOX2_20726797_ChIP-Seq_SW620_Human1.34897866
98* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.31606862
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30051781
100* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.29721405
101FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27881027
102SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27355860
103PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26130799
104* EOMES_21245162_ChIP-Seq_HESCs_Human1.25507152
105TP53_18474530_ChIP-ChIP_U2OS_Human1.25391820
106* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.24831333
107* CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23109358
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22979923
109GATA6_25053715_ChIP-Seq_YYC3_Human1.22916971
110CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22294004
111STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22054183
112XRN2_22483619_ChIP-Seq_HELA_Human1.21857491
113GABP_19822575_ChIP-Seq_HepG2_Human1.21574444
114* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.21401932
115MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.20167049
116* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19448133
117GATA4_25053715_ChIP-Seq_YYC3_Human1.19279854
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19265549
119THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18298098
120AR_21572438_ChIP-Seq_LNCaP_Human1.18214039
121SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17653874
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16917656
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16498259
124TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.12413093
125* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12332352
126* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12332352
127MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12181532
128UBF1/2_26484160_Chip-Seq_HMECs_Human1.11060576
129SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10282330
130CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09795318
131* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09674658
132FOXO3_23340844_ChIP-Seq_DLD1_Human1.09292265
133E2F7_22180533_ChIP-Seq_HELA_Human1.09228036
134SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07076809
135SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07076809
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06778373
137MYC_18555785_ChIP-Seq_MESCs_Mouse1.06554319
138EZH2_27304074_Chip-Seq_ESCs_Mouse1.06087668
139* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05818164
140* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05818164
141MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05193094
142TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04631146
143CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04156868
144NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03821605
145* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.03595679
146* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03543923
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03505503
148CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03407174
149NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03370456
150* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03352214
151FOXA2_19822575_ChIP-Seq_HepG2_Human1.02554245
152* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02156484
153ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01137431
154* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01093512
155AHR_22903824_ChIP-Seq_MCF-7_Human1.00969119
156* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00759985
157TP53_22127205_ChIP-Seq_IMR90_Human1.00597809
158SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00582133
159* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00368569
160MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00346394
161* RING1B_27294783_Chip-Seq_NPCs_Mouse0.99815992
162PIAS1_25552417_ChIP-Seq_VCAP_Human0.99559981
163STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99249510
164* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.97801099
165FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97713534
166PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97667771
167SOX2_16153702_ChIP-ChIP_HESCs_Human0.97231169
168TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95513765
169CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95221053
170TTF2_22483619_ChIP-Seq_HELA_Human0.94737248

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.12528783
2MP0005503_abnormal_tendon_morphology4.44308625
3MP0005275_abnormal_skin_tensile3.76453933
4MP0004272_abnormal_basement_membrane3.32819989
5MP0001958_emphysema3.13915392
6MP0003941_abnormal_skin_development3.06424582
7MP0010234_abnormal_vibrissa_follicle2.77703068
8MP0009384_cardiac_valve_regurgitation2.73432105
9MP0003705_abnormal_hypodermis_morpholog2.70908613
10MP0005360_urolithiasis2.61074085
11MP0010030_abnormal_orbit_morphology2.55598457
12MP0009780_abnormal_chondrocyte_physiolo2.37259197
13MP0009250_abnormal_appendicular_skeleto2.33812993
14MP0000537_abnormal_urethra_morphology2.32236341
15MP0002282_abnormal_trachea_morphology2.30005767
16MP0003279_aneurysm2.29585990
17* MP0003385_abnormal_body_wall2.24969959
18MP0003315_abnormal_perineum_morphology2.19454891
19MP0002938_white_spotting2.03956272
20MP0009697_abnormal_copulation1.98633106
21MP0004264_abnormal_extraembryonic_tissu1.94784298
22MP0000566_synostosis1.91020921
23MP0003937_abnormal_limbs/digits/tail_de1.81874417
24MP0002295_abnormal_pulmonary_circulatio1.81484886
25MP0005508_abnormal_skeleton_morphology1.81043407
26MP0000751_myopathy1.80941543
27MP0002877_abnormal_melanocyte_morpholog1.80137074
28MP0005623_abnormal_meninges_morphology1.79748244
29MP0009053_abnormal_anal_canal1.77936470
30* MP0003942_abnormal_urinary_system1.77209267
31MP0010368_abnormal_lymphatic_system1.76133647
32MP0002249_abnormal_larynx_morphology1.75898738
33MP0003115_abnormal_respiratory_system1.63567945
34MP0003191_abnormal_cellular_cholesterol1.61935363
35MP0005248_abnormal_Harderian_gland1.56611989
36MP0004957_abnormal_blastocyst_morpholog1.56188269
37MP0003136_yellow_coat_color1.54499479
38* MP0000516_abnormal_urinary_system1.52810527
39* MP0005367_renal/urinary_system_phenotyp1.52810527
40* MP0000762_abnormal_tongue_morphology1.49378072
41* MP0000534_abnormal_ureter_morphology1.49376327
42MP0003123_paternal_imprinting1.48706574
43MP0002108_abnormal_muscle_morphology1.46681230
44MP0000049_abnormal_middle_ear1.45372277
45MP0003122_maternal_imprinting1.43184603
46MP0004134_abnormal_chest_morphology1.42301818
47MP0004133_heterotaxia1.41268916
48MP0001299_abnormal_eye_distance/1.41182554
49MP0003890_abnormal_embryonic-extraembry1.40457478
50MP0001666_abnormal_nutrient_absorption1.36264646
51MP0003693_abnormal_embryo_hatching1.35642180
52* MP0000428_abnormal_craniofacial_morphol1.34113667
53MP0001879_abnormal_lymphatic_vessel1.33625157
54MP0003755_abnormal_palate_morphology1.32404705
55* MP0001293_anophthalmia1.31082374
56MP0005171_absent_coat_pigmentation1.29834211
57* MP0003935_abnormal_craniofacial_develop1.28194053
58* MP0002932_abnormal_joint_morphology1.26694488
59MP0005365_abnormal_bile_salt1.26052414
60MP0003566_abnormal_cell_adhesion1.25569990
61MP0001915_intracranial_hemorrhage1.25270826
62* MP0000432_abnormal_head_morphology1.25191233
63MP0000733_abnormal_muscle_development1.23259251
64MP0000163_abnormal_cartilage_morphology1.21181564
65MP0003567_abnormal_fetal_cardiomyocyte1.20204205
66MP0005330_cardiomyopathy1.18274127
67MP0005501_abnormal_skin_physiology1.18076099
68* MP0002116_abnormal_craniofacial_bone1.17559960
69MP0005023_abnormal_wound_healing1.17023493
70* MP0000767_abnormal_smooth_muscle1.15765506
71MP0008004_abnormal_stomach_pH1.14418383
72MP0004233_abnormal_muscle_weight1.14111353
73MP0002089_abnormal_postnatal_growth/wei1.13834181
74* MP0001672_abnormal_embryogenesis/_devel1.13777456
75* MP0005380_embryogenesis_phenotype1.13777456
76MP0002796_impaired_skin_barrier1.13668005
77MP0001730_embryonic_growth_arrest1.13554409
78MP0004185_abnormal_adipocyte_glucose1.13238237
79MP0005058_abnormal_lysosome_morphology1.12295978
80MP0002115_abnormal_skeleton_extremities1.11959416
81* MP0003984_embryonic_growth_retardation1.08926503
82* MP0002111_abnormal_tail_morphology1.08537479
83MP0001849_ear_inflammation1.07103920
84MP0005076_abnormal_cell_differentiation1.06874336
85* MP0002109_abnormal_limb_morphology1.06552464
86MP0002060_abnormal_skin_morphology1.06265896
87* MP0005388_respiratory_system_phenotype1.05605431
88* MP0002133_abnormal_respiratory_system1.05605431
89* MP0002086_abnormal_extraembryonic_tissu1.04870756
90* MP0001175_abnormal_lung_morphology1.04212283
91MP0000462_abnormal_digestive_system1.04170061
92MP0001346_abnormal_lacrimal_gland1.04112166
93MP0001697_abnormal_embryo_size1.03563119
94* MP0003119_abnormal_digestive_system1.01709661
95MP0000749_muscle_degeneration1.01345339
96MP0005165_increased_susceptibility_to1.01033818
97* MP0002925_abnormal_cardiovascular_devel1.00941908
98MP0001177_atelectasis0.99731273
99MP0006054_spinal_hemorrhage0.99634081
100MP0003283_abnormal_digestive_organ0.98877264
101* MP0002233_abnormal_nose_morphology0.97964990
102MP0003195_calcinosis0.95966218
103MP0001243_abnormal_dermal_layer0.95716832
104* MP0002697_abnormal_eye_size0.95224475
105MP0003111_abnormal_nucleus_morphology0.94428397
106MP0005085_abnormal_gallbladder_physiolo0.93672749
107MP0003077_abnormal_cell_cycle0.90046951
108MP0003828_pulmonary_edema0.89628619
109* MP0002080_prenatal_lethality0.89624120
110MP0004197_abnormal_fetal_growth/weight/0.89581010
111MP0006138_congestive_heart_failure0.89087370
112* MP0005197_abnormal_uvea_morphology0.88932803
113* MP0002114_abnormal_axial_skeleton0.88760168
114* MP0002085_abnormal_embryonic_tissue0.88535296
115MP0004782_abnormal_surfactant_physiolog0.88087391
116MP0002139_abnormal_hepatobiliary_system0.87639481
117* MP0002177_abnormal_outer_ear0.87424059
118MP0003950_abnormal_plasma_membrane0.87070943
119MP0002098_abnormal_vibrissa_morphology0.86841777
120MP0005187_abnormal_penis_morphology0.85963653
121MP0001542_abnormal_bone_strength0.85815709
122MP0003121_genomic_imprinting0.84876763
123MP0010678_abnormal_skin_adnexa0.84311178
124* MP0002113_abnormal_skeleton_development0.83029281
125* MP0001614_abnormal_blood_vessel0.82444780
126MP0002128_abnormal_blood_circulation0.82395017
127MP0004883_abnormal_blood_vessel0.80608044
128* MP0001286_abnormal_eye_development0.77657526
129MP0002896_abnormal_bone_mineralization0.77549920
130MP0001661_extended_life_span0.76975723
131MP0000858_altered_metastatic_potential0.76960218
132MP0000750_abnormal_muscle_regeneration0.76889496
133* MP0002084_abnormal_developmental_patter0.76591237
134MP0004084_abnormal_cardiac_muscle0.75929920
135MP0005595_abnormal_vascular_smooth0.75438886
136MP0005408_hypopigmentation0.74825383
137MP0002933_joint_inflammation0.74729729
138* MP0002092_abnormal_eye_morphology0.74374733
139* MP0001340_abnormal_eyelid_morphology0.73379845
140MP0010352_gastrointestinal_tract_polyps0.71685771
141MP0000613_abnormal_salivary_gland0.69475469
142MP0000647_abnormal_sebaceous_gland0.68202257
143* MP0002088_abnormal_embryonic_growth/wei0.66723835
144* MP0000266_abnormal_heart_morphology0.65918213
145MP0008932_abnormal_embryonic_tissue0.65554156

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.50829094
2Deep venous thrombosis (HP:0002625)4.46577736
3Broad metatarsal (HP:0001783)4.24659968
4Abnormality of the parietal bone (HP:0002696)4.20868459
5Short 4th metacarpal (HP:0010044)4.17877719
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.17877719
7Premature rupture of membranes (HP:0001788)4.07516056
8Shallow orbits (HP:0000586)4.03922001
9Short nail (HP:0001799)3.44979771
10Ankle contracture (HP:0006466)3.42001380
11Right ventricular cardiomyopathy (HP:0011663)3.36664308
12Vascular calcification (HP:0004934)3.32402374
13Aortic aneurysm (HP:0004942)3.20166397
14Abnormality of the 4th metacarpal (HP:0010012)3.15645570
15Midline defect of the nose (HP:0004122)3.15380601
16Cardiovascular calcification (HP:0011915)3.07872771
17Abnormality of the umbilical cord (HP:0010881)3.06879794
18Joint hemorrhage (HP:0005261)2.97341373
19Abnormality of the distal phalanges of the toes (HP:0010182)2.96570472
20Aortic dissection (HP:0002647)2.92233619
21Reduced subcutaneous adipose tissue (HP:0003758)2.88866506
22Soft skin (HP:0000977)2.85627584
23Wrist flexion contracture (HP:0001239)2.78685318
24Glucose intolerance (HP:0000833)2.78377168
25Abnormality of carpal bone ossification (HP:0006257)2.78073972
26Abnormality of the distal phalanx of the thumb (HP:0009617)2.69612020
27Partial duplication of the phalanx of hand (HP:0009999)2.67776392
28Cervical subluxation (HP:0003308)2.65064148
29Bell-shaped thorax (HP:0001591)2.63624731
30Atrophic scars (HP:0001075)2.61817462
31Osteolytic defects of the hand bones (HP:0009699)2.59037161
32Osteolytic defects of the phalanges of the hand (HP:0009771)2.59037161
33Bladder diverticulum (HP:0000015)2.58924495
34Abnormal umbilical cord blood vessels (HP:0011403)2.57880505
35Single umbilical artery (HP:0001195)2.57880505
36Abnormality of the fetal cardiovascular system (HP:0010948)2.57880505
37Entropion (HP:0000621)2.57043408
38Abnormal tarsal ossification (HP:0008369)2.56750468
39Abnormalities of placenta or umbilical cord (HP:0001194)2.55689307
40Coronal craniosynostosis (HP:0004440)2.50024359
41Follicular hyperkeratosis (HP:0007502)2.49321801
42Pulmonary artery stenosis (HP:0004415)2.46002975
43Prolonged partial thromboplastin time (HP:0003645)2.45278114
44Abnormality of glycolysis (HP:0004366)2.39683447
45Conjugated hyperbilirubinemia (HP:0002908)2.37051054
46Vascular tortuosity (HP:0004948)2.34957509
47Supernumerary ribs (HP:0005815)2.33204278
48Mesomelia (HP:0003027)2.32158498
49Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.30357214
50Menorrhagia (HP:0000132)2.28220192
51Small epiphyses (HP:0010585)2.25798505
52Aplasia cutis congenita (HP:0001057)2.25308406
53Broad toe (HP:0001837)2.25209526
54Partial duplication of thumb phalanx (HP:0009944)2.24855643
55Neonatal short-limb short stature (HP:0008921)2.23431315
56Supernumerary bones of the axial skeleton (HP:0009144)2.23038576
57Wide anterior fontanel (HP:0000260)2.21444973
58Insomnia (HP:0100785)2.20672155
59Hypoplasia of the capital femoral epiphysis (HP:0003090)2.20117442
60Increased serum pyruvate (HP:0003542)2.19154472
61Increased connective tissue (HP:0009025)2.18679740
62Abnormality of the nasolacrimal system (HP:0000614)2.17182542
63Abnormality of complement system (HP:0005339)2.15206117
64Abnormality of the acetabulum (HP:0003170)2.10902618
65Hemorrhage of the eye (HP:0011885)2.10326815
66Trismus (HP:0000211)2.09769655
67Myelomeningocele (HP:0002475)2.09384432
68Hypoalphalipoproteinemia (HP:0003233)2.07383138
69Alacrima (HP:0000522)2.06964006
70Nasolacrimal duct obstruction (HP:0000579)2.06280347
71Premature skin wrinkling (HP:0100678)2.06037969
72Abnormality of the intrinsic pathway (HP:0010989)2.05987022
73Abnormal delivery (HP:0001787)2.05940973
74Wormian bones (HP:0002645)2.04808565
75Abnormality of dentin (HP:0010299)2.04750533
76Selective tooth agenesis (HP:0001592)2.04727224
77Blue sclerae (HP:0000592)2.04663576
78Myocardial infarction (HP:0001658)2.04343495
79Hip contracture (HP:0003273)2.03011507
80Thin skin (HP:0000963)2.02677065
81Abnormality of aromatic amino acid family metabolism (HP:0004338)2.02542290
82Hypoplastic pelvis (HP:0008839)2.02305797
83Broad ribs (HP:0000885)2.02016264
84Preaxial foot polydactyly (HP:0001841)2.01235070
85Abnormal foot bone ossification (HP:0010675)2.00732064
86Rough bone trabeculation (HP:0100670)2.00726737
87Xanthomatosis (HP:0000991)1.99783355
88Hypoplastic labia majora (HP:0000059)1.99070826
89Flat acetabular roof (HP:0003180)1.98798269
90Broad hallux (HP:0010055)1.98669453
91Natal tooth (HP:0000695)1.97566097
92Abnormality of the lacrimal duct (HP:0011481)1.97463196
93Aplasia involving bones of the upper limbs (HP:0009823)1.96857278
94Aplasia of the phalanges of the hand (HP:0009802)1.96857278
95Aplasia involving bones of the extremities (HP:0009825)1.96857278
96Hypolipoproteinemia (HP:0010981)1.95708586
97Upper limb muscle weakness (HP:0003484)1.95498559
98Abnormal number of incisors (HP:0011064)1.94356076
99Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92932351
100Distal lower limb amyotrophy (HP:0008944)1.92432873
101Down-sloping shoulders (HP:0200021)1.92210103
102Secondary amenorrhea (HP:0000869)1.92152668
103Pili torti (HP:0003777)1.91400866
104Hyperextensible skin (HP:0000974)1.90840055
105Abnormality of the common coagulation pathway (HP:0010990)1.90818529
106Abnormality of the nasal septum (HP:0000419)1.90315562
107Sparse eyelashes (HP:0000653)1.89492260
108Short hallux (HP:0010109)1.88132682
109Dilatation of the ascending aorta (HP:0005111)1.88092624
110Limb-girdle muscle atrophy (HP:0003797)1.88083754
111Overgrowth (HP:0001548)1.87831431
112Abnormal ossification of hand bones (HP:0005921)1.87747151
113Trigonocephaly (HP:0000243)1.85934423
114Hypercholesterolemia (HP:0003124)1.85840425
115Spinal rigidity (HP:0003306)1.85437267
116Upper limb amyotrophy (HP:0009129)1.85432236
117Distal upper limb amyotrophy (HP:0007149)1.85432236
118Diaphragmatic weakness (HP:0009113)1.82756915
119Abnormality of the labia minora (HP:0012880)1.82153789
120Hypobetalipoproteinemia (HP:0003563)1.81856206
121Limited hip movement (HP:0008800)1.80801390
122White forelock (HP:0002211)1.80766087
123Advanced eruption of teeth (HP:0006288)1.80555368
124Distal lower limb muscle weakness (HP:0009053)1.80155539
125Peritonitis (HP:0002586)1.79997075
126* Deviation of the thumb (HP:0009603)1.79400282
127Colon cancer (HP:0003003)1.78650969
128Arterial tortuosity (HP:0005116)1.78090574
129Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77951473
130Absent epiphyses (HP:0010577)1.77951473
131Cerebral aneurysm (HP:0004944)1.77896687
132Mitral valve prolapse (HP:0001634)1.76603890
133Asymmetry of the thorax (HP:0001555)1.76559633
134Neonatal death (HP:0003811)1.76209926
135Concave nail (HP:0001598)1.75464019
136Abnormality of the Achilles tendon (HP:0005109)1.75264865
137Intrahepatic cholestasis (HP:0001406)1.74922781
138Vertebral compression fractures (HP:0002953)1.74919144
139Bronchomalacia (HP:0002780)1.74836417
140Biconcave vertebral bodies (HP:0004586)1.74754581
141Wide cranial sutures (HP:0010537)1.74599162
142Ulnar bowing (HP:0003031)1.74121167
143Hypoplasia of the iris (HP:0007676)1.73986133
144Hepatoblastoma (HP:0002884)1.73706983
145Abnormality of the labia majora (HP:0012881)1.73263258
146Short clavicles (HP:0000894)1.72848601
147Fragile skin (HP:0001030)1.72605243
148Coxa vara (HP:0002812)1.72509170
149Amyloidosis (HP:0011034)1.72201808
150Abnormal glucose tolerance (HP:0001952)1.72031334
151Shoulder girdle muscle weakness (HP:0003547)1.71539269
152Type 1 muscle fiber predominance (HP:0003803)1.70978314
153Knee flexion contracture (HP:0006380)1.69753837
154Aplasia/Hypoplasia of the hallux (HP:0008362)1.69470330
155Abnormal trabecular bone morphology (HP:0100671)1.68798591
156Abnormality of the 2nd finger (HP:0004100)1.68525277
157Abnormality of the incisor (HP:0000676)1.67304902
158Abnormality of incisor morphology (HP:0011063)1.66866614
159Abnormal vertebral ossification (HP:0100569)1.66808612
160Hypoplasia of the maxilla (HP:0000327)1.66793408
161Achilles tendon contracture (HP:0001771)1.66638115
162Broad face (HP:0000283)1.66432571
163Tracheomalacia (HP:0002779)1.65933768
164Broad long bones (HP:0005622)1.65560402
165Abnormal hand bone ossification (HP:0010660)1.65475828
166Short phalanx of the thumb (HP:0009660)1.65433916
167Hand muscle atrophy (HP:0009130)1.64744189
168Abnormality of the phalanges of the 2nd finger (HP:0009541)1.63304672
169Round ear (HP:0100830)1.63160931
170Vitreoretinal degeneration (HP:0000655)1.62443427
171Cutaneous finger syndactyly (HP:0010554)1.61384540
172Renal duplication (HP:0000075)1.61305583
173Delayed cranial suture closure (HP:0000270)1.60796924
174Patchy hypopigmentation of hair (HP:0011365)1.60597250
175Recurrent corneal erosions (HP:0000495)1.59855510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.36993828
2LATS14.09325840
3DDR23.57351096
4EPHB22.82255808
5PDGFRA2.73350899
6TYRO32.66360813
7STK38L2.50106871
8EPHA22.45284169
9VRK22.33972643
10LMTK22.33419999
11TESK22.33293324
12EPHA32.25195392
13TTN2.18894617
14MYLK2.13794829
15FGFR22.01716714
16TIE11.92262509
17LATS21.92232291
18PDGFRB1.89821989
19ZAK1.87270735
20MET1.83590935
21AKT31.80383292
22PBK1.75769771
23PIK3CA1.74952649
24MAP3K121.66183645
25FER1.60229642
26PAK41.57982947
27TGFBR21.54635207
28OBSCN1.54240569
29SIK11.51203903
30STK31.47843267
31NEK11.42103463
32TGFBR11.39285802
33CDK121.37846576
34STK241.35283614
35CASK1.34659864
36CDK81.34057313
37CDK71.31433813
38TSSK61.30881129
39NUAK11.29749951
40PAK21.28859514
41STK101.28030694
42SCYL21.25530564
43ROCK11.23493621
44FGFR41.23050745
45TESK11.22629780
46LIMK11.22233545
47FGFR11.19613448
48PTK21.19462711
49EIF2AK11.18644293
50SRPK11.18040192
51MKNK11.15418505
52IRAK31.14844342
53ERN11.14025370
54DMPK1.12962267
55SMG11.11153878
56FES1.09397052
57NEK21.08706206
58BCR1.04636907
59MAPKAPK31.04562059
60MKNK21.03656962
61ICK1.02431966
62BRSK11.01882109
63NEK91.00829571
64BUB10.99540583
65ARAF0.95371158
66DAPK10.88725834
67BMX0.87255455
68PIM20.83676136
69STK160.83110766
70PKN20.80359485
71KDR0.78572665
72ROCK20.78449535
73ABL20.78343920
74PLK30.77541961
75CSK0.76553201
76TNIK0.76237089
77TTK0.75703700
78STK390.75597457
79GRK10.75356404
80ERBB30.74813526
81NLK0.74671803
82YES10.74162047
83RPS6KB20.73148222
84GSK3A0.70876156
85CHEK20.70214505
86MTOR0.69138472
87INSR0.66895989
88MAP3K80.65298193
89RIPK10.64946737
90PTK2B0.63112591
91NEK60.61796800
92TAF10.61296313
93ILK0.60614849
94WNK40.60498356
95CLK10.59511343
96LRRK20.59440198
97WEE10.58216650
98NME20.58199237
99RPS6KA40.57568834
100AURKB0.56144557
101EIF2AK20.55770439
102DYRK20.55503856
103BRSK20.55186516
104PLK20.54124693
105BCKDK0.53627707
106CDC42BPA0.53058679
107BRD40.52541581
108PHKG10.51505434
109PHKG20.51505434
110STK40.51493355
111PTK60.50591696
112NME10.49486457
113ERBB40.48621883
114TRIM280.48363540
115AURKA0.47949542
116WNK10.46108974
117MELK0.44843020
118PLK40.44816188
119VRK10.43192521
120MAP3K30.42962354
121TAOK20.41243775
122PRKD20.40323364
123AKT20.39433623
124OXSR10.37700619
125PAK10.37540495
126PRKG20.37360831
127CHUK0.36859733
128CSNK1A1L0.35486904
129CDK90.35283186
130ERBB20.35080002
131MAPK10.34595687
132PLK10.34528395
133PRKCI0.34232094
134MST40.33889943
135BRAF0.33553891
136EEF2K0.31995581
137FRK0.31990238
138PRPF4B0.31858030
139TRPM70.30872188
140CDC70.29600151

Predicted pathways (KEGG)

RankGene SetZ-score
1* Basal cell carcinoma_Homo sapiens_hsa052174.03256347
2ECM-receptor interaction_Homo sapiens_hsa045123.81985416
3* Hippo signaling pathway_Homo sapiens_hsa043903.05406573
4Adherens junction_Homo sapiens_hsa045203.01971518
5* Hedgehog signaling pathway_Homo sapiens_hsa043402.94275751
6* TGF-beta signaling pathway_Homo sapiens_hsa043502.86816551
7Focal adhesion_Homo sapiens_hsa045102.69922725
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.62390767
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.53287275
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.40359541
11Complement and coagulation cascades_Homo sapiens_hsa046102.24382604
12Tight junction_Homo sapiens_hsa045302.17648977
13Protein digestion and absorption_Homo sapiens_hsa049742.09207041
14* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.06709698
15Biosynthesis of amino acids_Homo sapiens_hsa012302.05603710
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.01664956
17N-Glycan biosynthesis_Homo sapiens_hsa005101.99803109
18Wnt signaling pathway_Homo sapiens_hsa043101.95581336
19MicroRNAs in cancer_Homo sapiens_hsa052061.89928710
20Proteoglycans in cancer_Homo sapiens_hsa052051.87298111
21Steroid biosynthesis_Homo sapiens_hsa001001.86465302
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.85546239
23Fatty acid elongation_Homo sapiens_hsa000621.82751992
24Melanoma_Homo sapiens_hsa052181.75392895
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.74927219
26Galactose metabolism_Homo sapiens_hsa000521.73558461
27Small cell lung cancer_Homo sapiens_hsa052221.71076917
28Viral myocarditis_Homo sapiens_hsa054161.70825455
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.69975790
30Pyruvate metabolism_Homo sapiens_hsa006201.69281829
31Axon guidance_Homo sapiens_hsa043601.69240307
32PI3K-Akt signaling pathway_Homo sapiens_hsa041511.63544669
33Pentose phosphate pathway_Homo sapiens_hsa000301.62660911
34Dilated cardiomyopathy_Homo sapiens_hsa054141.62456337
35* Pathways in cancer_Homo sapiens_hsa052001.60385510
36Ribosome_Homo sapiens_hsa030101.60006078
37Cell cycle_Homo sapiens_hsa041101.55706045
38Carbon metabolism_Homo sapiens_hsa012001.48926511
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48558198
40Bladder cancer_Homo sapiens_hsa052191.47972015
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45329012
42Fructose and mannose metabolism_Homo sapiens_hsa000511.42999894
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.36606769
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.36160873
45Spliceosome_Homo sapiens_hsa030401.30013247
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.29089741
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28847061
48Amoebiasis_Homo sapiens_hsa051461.27123646
49Prostate cancer_Homo sapiens_hsa052151.26013454
50Malaria_Homo sapiens_hsa051441.25525474
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20726262
52Sulfur metabolism_Homo sapiens_hsa009201.19958784
53RNA polymerase_Homo sapiens_hsa030201.17734943
54Fatty acid biosynthesis_Homo sapiens_hsa000611.16373939
55Notch signaling pathway_Homo sapiens_hsa043301.12628589
56RNA transport_Homo sapiens_hsa030131.08400848
57p53 signaling pathway_Homo sapiens_hsa041151.07455726
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06922320
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06179111
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06113996
61Glutathione metabolism_Homo sapiens_hsa004801.05171756
62Rap1 signaling pathway_Homo sapiens_hsa040151.02130132
63Arginine biosynthesis_Homo sapiens_hsa002200.99467475
64HTLV-I infection_Homo sapiens_hsa051660.99111415
65Homologous recombination_Homo sapiens_hsa034400.99035385
66Melanogenesis_Homo sapiens_hsa049160.98192673
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97707756
68Fatty acid metabolism_Homo sapiens_hsa012120.95661911
69Thyroid cancer_Homo sapiens_hsa052160.95633565
70Sphingolipid metabolism_Homo sapiens_hsa006000.95407188
71Vibrio cholerae infection_Homo sapiens_hsa051100.94851850
72Fat digestion and absorption_Homo sapiens_hsa049750.94490265
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.94375851
74Starch and sucrose metabolism_Homo sapiens_hsa005000.93320014
75Phenylalanine metabolism_Homo sapiens_hsa003600.92840499
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92562889
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92177816
78Mismatch repair_Homo sapiens_hsa034300.91222220
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88962140
80Basal transcription factors_Homo sapiens_hsa030220.88814174
81Mineral absorption_Homo sapiens_hsa049780.88200665
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83176392
83Proteasome_Homo sapiens_hsa030500.82017494
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.80300975
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80257935
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76577226
87One carbon pool by folate_Homo sapiens_hsa006700.76108963
88Fatty acid degradation_Homo sapiens_hsa000710.75395657
89Fanconi anemia pathway_Homo sapiens_hsa034600.74804291
90Vitamin B6 metabolism_Homo sapiens_hsa007500.74287764
91Nucleotide excision repair_Homo sapiens_hsa034200.73792253
92Colorectal cancer_Homo sapiens_hsa052100.70742118
93mRNA surveillance pathway_Homo sapiens_hsa030150.70495051
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69629805
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67827790
96PPAR signaling pathway_Homo sapiens_hsa033200.67249856
97RNA degradation_Homo sapiens_hsa030180.67174435
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67157787
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66842126
100Endometrial cancer_Homo sapiens_hsa052130.66215468
101Ether lipid metabolism_Homo sapiens_hsa005650.65528537
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.65223230
103Renal cell carcinoma_Homo sapiens_hsa052110.63426992
104Tyrosine metabolism_Homo sapiens_hsa003500.63359193
105Arachidonic acid metabolism_Homo sapiens_hsa005900.63043243
106Non-homologous end-joining_Homo sapiens_hsa034500.62690562
107Base excision repair_Homo sapiens_hsa034100.62435241
108Other glycan degradation_Homo sapiens_hsa005110.59661868
109Prion diseases_Homo sapiens_hsa050200.58109878
110Cardiac muscle contraction_Homo sapiens_hsa042600.57997508
111Propanoate metabolism_Homo sapiens_hsa006400.57508896
112DNA replication_Homo sapiens_hsa030300.56861817
113Purine metabolism_Homo sapiens_hsa002300.55785025
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55209816
115Metabolic pathways_Homo sapiens_hsa011000.53239041
116Arginine and proline metabolism_Homo sapiens_hsa003300.52114168
117Chronic myeloid leukemia_Homo sapiens_hsa052200.50799097
118Renin-angiotensin system_Homo sapiens_hsa046140.49081305
119Lysine degradation_Homo sapiens_hsa003100.46265206
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.45151598
121Ras signaling pathway_Homo sapiens_hsa040140.44628185
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42634503
123Thyroid hormone synthesis_Homo sapiens_hsa049180.42322078
124Bile secretion_Homo sapiens_hsa049760.40623738
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.40483011
126Peroxisome_Homo sapiens_hsa041460.39560704
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38958842
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.38063572
129Platelet activation_Homo sapiens_hsa046110.37783187
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37282101
131Viral carcinogenesis_Homo sapiens_hsa052030.34507768
132Folate biosynthesis_Homo sapiens_hsa007900.33005807
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32102426
134Chemical carcinogenesis_Homo sapiens_hsa052040.31292792
135Huntingtons disease_Homo sapiens_hsa050160.31004339
136Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29385312
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28860268
138Vitamin digestion and absorption_Homo sapiens_hsa049770.28275734
139Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25854619
140HIF-1 signaling pathway_Homo sapiens_hsa040660.24897278
141Shigellosis_Homo sapiens_hsa051310.22212816
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19819289
143Sulfur relay system_Homo sapiens_hsa041220.16535139
144Ovarian steroidogenesis_Homo sapiens_hsa049130.15245392
145Pyrimidine metabolism_Homo sapiens_hsa002400.15217907
146Gap junction_Homo sapiens_hsa045400.14945821
147* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13634892

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »